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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CELF5-RDH8 (FusionGDB2 ID:15634)

Fusion Gene Summary for CELF5-RDH8

check button Fusion gene summary
Fusion gene informationFusion gene name: CELF5-RDH8
Fusion gene ID: 15634
HgeneTgene
Gene symbol

CELF5

RDH8

Gene ID

60680

50700

Gene nameCUGBP Elav-like family member 5retinol dehydrogenase 8
SynonymsBRUNOL-5|BRUNOL5|CELF-5PRRDH|SDR28C2
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionCUGBP Elav-like family member 5CUG-BP and ETR-3 like factor 5RNA-binding protein BRUNOL-5bruno-like 5 RNA binding proteinretinol dehydrogenase 8photoreceptor outer segment all-trans retinol dehydrogenaseretinol dehydrogenase 8 (all-trans)short chain dehydrogenase/reductase family 28C member 2
Modification date2020031320200313
UniProtAcc

Q8N6W0

.
Ensembl transtripts involved in fusion geneENST00000292672, ENST00000541430, 
ENST00000588101, 		ENST00000171214, 
ENST00000591589, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 2 X 4=32
# samples 35
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/32*10)=0.643856189774725
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CELF5 [Title/Abstract] AND RDH8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCELF5(3225616)-RDH8(10127733), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCELF5

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

11158314


check buttonFusion gene breakpoints across CELF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RDH8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A7CF-01ACELF5chr19

3225616

-RDH8chr19

10127733

+
ChimerDB4LGGTCGA-TM-A7CF-01ACELF5chr19

3225616

+RDH8chr19

10127733

+
ChimerDB4LGGTCGA-TM-A7CF-02ACELF5chr19

3224996

-RDH8chr19

10127733

+


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Fusion Gene ORF analysis for CELF5-RDH8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000292672ENST00000171214CELF5chr19

3224996

-RDH8chr19

10127733

+
In-frameENST00000292672ENST00000591589CELF5chr19

3224996

-RDH8chr19

10127733

+
In-frameENST00000541430ENST00000171214CELF5chr19

3224996

-RDH8chr19

10127733

+
In-frameENST00000541430ENST00000591589CELF5chr19

3224996

-RDH8chr19

10127733

+
intron-3CDSENST00000292672ENST00000171214CELF5chr19

3225616

+RDH8chr19

10127733

+
intron-3CDSENST00000292672ENST00000591589CELF5chr19

3225616

+RDH8chr19

10127733

+
intron-3CDSENST00000541430ENST00000171214CELF5chr19

3225616

+RDH8chr19

10127733

+
intron-3CDSENST00000541430ENST00000591589CELF5chr19

3225616

+RDH8chr19

10127733

+
intron-3CDSENST00000588101ENST00000171214CELF5chr19

3225616

+RDH8chr19

10127733

+
intron-3CDSENST00000588101ENST00000171214CELF5chr19

3224996

-RDH8chr19

10127733

+
intron-3CDSENST00000588101ENST00000591589CELF5chr19

3225616

+RDH8chr19

10127733

+
intron-3CDSENST00000588101ENST00000591589CELF5chr19

3224996

-RDH8chr19

10127733

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000292672CELF5chr193224996-ENST00000171214RDH8chr1910127733+165829611851395
ENST00000292672CELF5chr193224996-ENST00000591589RDH8chr1910127733+1659296371128363
ENST00000541430CELF5chr193224996-ENST00000171214RDH8chr1910127733+165729511840395
ENST00000541430CELF5chr193224996-ENST00000591589RDH8chr1910127733+1658295361127363

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000292672ENST00000171214CELF5chr193224996-RDH8chr1910127733+0.0180418980.9819581
ENST00000292672ENST00000591589CELF5chr193224996-RDH8chr1910127733+0.0180539210.98194605
ENST00000541430ENST00000171214CELF5chr193224996-RDH8chr1910127733+0.0179846790.9820154
ENST00000541430ENST00000591589CELF5chr193224996-RDH8chr1910127733+0.0179850480.9820149

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Fusion Genomic Features for CELF5-RDH8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CELF5-RDH8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3225616/chr19:10127733)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELF5

Q8N6W0

.
FUNCTION: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRDH8chr19:3224996chr19:10127733ENST0000017121406137_15734312.0TransmembraneHelical
TgeneRDH8chr19:3224996chr19:10127733ENST0000017121406169_18934312.0TransmembraneHelical
TgeneRDH8chr19:3224996chr19:10127733ENST000001712140686_10634312.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELF5chr19:3224996chr19:10127733ENST00000292672-113134_21486493.6666666666667DomainRRM 2
HgeneCELF5chr19:3224996chr19:10127733ENST00000292672-113400_47886493.6666666666667DomainRRM 3
HgeneCELF5chr19:3224996chr19:10127733ENST00000292672-11345_12686493.6666666666667DomainRRM 1
HgeneCELF5chr19:3224996chr19:10127733ENST00000541430-112134_21486410.0DomainRRM 2
HgeneCELF5chr19:3224996chr19:10127733ENST00000541430-112400_47886410.0DomainRRM 3
HgeneCELF5chr19:3224996chr19:10127733ENST00000541430-11245_12686410.0DomainRRM 1
TgeneRDH8chr19:3224996chr19:10127733ENST00000171214069_1834312.0Nucleotide bindingNADP


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Fusion Gene Sequence for CELF5-RDH8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15634_15634_1_CELF5-RDH8_CELF5_chr19_3224996_ENST00000292672_RDH8_chr19_10127733_ENST00000171214_length(transcript)=1658nt_BP=296nt
CCGCCGCCGCCGCCGCCGGCTCGGTCCCGCGCCCGCCATGGCCCGCCTGACGGAGAGCGAGGCGCGCCGGCAGCAGCAGCAGCTCCTGCA
GCCGCGGCCCTCGCCCGTGGGCAGCAGCGGGCCCGAGCCCCCCGGGGGGCAGCCCGACGGCATGAAGGACCTGGACGCCATCAAACTCTT
CGTGGGCCAGATCCCGCGGCACCTGGACGAGAAGGACCTCAAGCCGCTCTTCGAGCAGTTCGGCCGCATCTACGAGCTCACGGTGCTCAA
AGACCCCTACACGGGGATGCACAAAGTCGTGGCCACCATGAGGGACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCT
GGGGCAGACCCTCACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATCCAGGGAGAAGTGGACGT
GCTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAGGGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTT
CGGAGCTGTCCGTCTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATCAGCAGTGTCATGGGCCT
GCAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTCGCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTT
CAACATCTTCATCTCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTTTCTATGGCTGAGTTCCC
AGGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTATCTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACA
GGACGTGGTTCAGGCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGCTACTCGCCGCTGACCAC
GCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACGACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCT
TCAATGTCTGTCCTGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGAGCAGAACAGAGCTTCACGATCCCCATCCCTGAACAACCAGA
CCTCTTCATTCCACATCTAATTCAAAGGATGAACAGACTCTTCATTTATTCATTCTGCAAACTCCCCCTCCCCTCCTCTGTGCCTAGACA
TGGCTAGAATCCCAGAAGGGCCTTTATTTTCAGGCATAGACTCCTCTGTGGTCACAGCTGGAGCACAGAGAGGGACCCTGGGAACTTGGC
CTGGGAAGCCCAGAGCAGGAAGCCACAGCTGTCTCTGGGAAAGCAAGGGAGGCTTCCTGGAGGAAGCGGCATTGTTATGAGCCTTGAAGG
AAGAGACAGACTCTGCTACATTCAACCTCGTGACTTCATGATCCTGGGCCTGAGAACACAGGAATGATTCATAGCCCACCCCCCACCTCC
ATGCATACACCAGAGCTCTGTGGACCAAGGGGTCATTCCTGGTCACACACTCCATCAGCAAAATGTATTTGAGCACACACCAGCAATGTA

>15634_15634_1_CELF5-RDH8_CELF5_chr19_3224996_ENST00000292672_RDH8_chr19_10127733_ENST00000171214_length(amino acids)=395AA_BP=0
MWNEEVWLFRDGDREALFCSSWPHPRWEAAAGQTLKAKVEEAWTAEEEAVGRSHIQAARGIHGFERGQRRVADVGLSAQGWSSRADDVDN
GLNHVLWVLSHGAKQLPGGWEIEVPEVVQGLRVSAWELSHRNLRQKLPLKLGDHGAWLHQGDEDVELQQLDSEAFEESLQGELGSCIDIV
EDDTLQAHDTADHHDVALPPPLHAWKHSFDETDSSEKVGVKDILHGSKAEPLQGPHQAHSSIIHQHVHFSLDTAETLGHRLITAHVQLGH
GEGLPQSLPSSCLQCLLLPQVPHGGHDFVHPRVGVFEHRELVDAAELLEERLEVLLVQVPRDLAHEEFDGVQVLHAVGLPPGGLGPAAAH

--------------------------------------------------------------
>15634_15634_2_CELF5-RDH8_CELF5_chr19_3224996_ENST00000292672_RDH8_chr19_10127733_ENST00000591589_length(transcript)=1659nt_BP=296nt
CCGCCGCCGCCGCCGCCGGCTCGGTCCCGCGCCCGCCATGGCCCGCCTGACGGAGAGCGAGGCGCGCCGGCAGCAGCAGCAGCTCCTGCA
GCCGCGGCCCTCGCCCGTGGGCAGCAGCGGGCCCGAGCCCCCCGGGGGGCAGCCCGACGGCATGAAGGACCTGGACGCCATCAAACTCTT
CGTGGGCCAGATCCCGCGGCACCTGGACGAGAAGGACCTCAAGCCGCTCTTCGAGCAGTTCGGCCGCATCTACGAGCTCACGGTGCTCAA
AGACCCCTACACGGGGATGCACAAAGTCGTGGCCACCATGAGGGACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCT
GGGGCAGACCCTCACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATCCAGGGAGAAGTGGACGT
GCTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAGGGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTT
CGGAGCTGTCCGTCTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATCAGCAGTGTCATGGGCCT
GCAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTCGCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTT
CAACATCTTCATCTCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTTTCTATGGCTGAGTTCCC
AGGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTATCTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACA
GGACGTGGTTCAGGCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGCTACTCGCCGCTGACCAC
GCTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACGACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCT
TCAATGTCTGTCCTGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGAGCAGAACAGAGCTTCACGATCCCCATCCCTGAACAACCAGA
CCTCTTCATTCCACATCTAATTCAAAGGATGAACAGACTCTTCATTTATTCATTCTGCAAACTCCCCCTCCCCTCCTCTGTGCCTAGACA
TGGCTAGAATCCCAGAAGGGCCTTTATTTTCAGGCATAGACTCCTCTGTGGTCACAGCTGGAGCACAGAGAGGGACCCTGGGAACTTGGC
CTGGGAAGCCCAGAGCAGGAAGCCACAGCTGTCTCTGGGAAAGCAAGGGAGGCTTCCTGGAGGAAGCGGCATTGTTATGAGCCTTGAAGG
AAGAGACAGACTCTGCTACATTCAACCTCGTGACTTCATGATCCTGGGCCTGAGAACACAGGAATGATTCATAGCCCACCCCCCACCTCC
ATGCATACACCAGAGCTCTGTGGACCAAGGGGTCATTCCTGGTCACACACTCCATCAGCAAAATGTATTTGAGCACACACCAGCAATGTA

>15634_15634_2_CELF5-RDH8_CELF5_chr19_3224996_ENST00000292672_RDH8_chr19_10127733_ENST00000591589_length(amino acids)=363AA_BP=86
MARLTESEARRQQQQLLQPRPSPVGSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKVVAT
MRDLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPG
MKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRD
LYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRV

--------------------------------------------------------------
>15634_15634_3_CELF5-RDH8_CELF5_chr19_3224996_ENST00000541430_RDH8_chr19_10127733_ENST00000171214_length(transcript)=1657nt_BP=295nt
CGCCGCCGCCGCCGCCGGCTCGGTCCCGCGCCCGCCATGGCCCGCCTGACGGAGAGCGAGGCGCGCCGGCAGCAGCAGCAGCTCCTGCAG
CCGCGGCCCTCGCCCGTGGGCAGCAGCGGGCCCGAGCCCCCCGGGGGGCAGCCCGACGGCATGAAGGACCTGGACGCCATCAAACTCTTC
GTGGGCCAGATCCCGCGGCACCTGGACGAGAAGGACCTCAAGCCGCTCTTCGAGCAGTTCGGCCGCATCTACGAGCTCACGGTGCTCAAA
GACCCCTACACGGGGATGCACAAAGTCGTGGCCACCATGAGGGACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCTG
GGGCAGACCCTCACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATCCAGGGAGAAGTGGACGTG
CTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAGGGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTC
GGAGCTGTCCGTCTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATCAGCAGTGTCATGGGCCTG
CAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTCGCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTC
AACATCTTCATCTCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTTTCTATGGCTGAGTTCCCA
GGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTATCTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACAG
GACGTGGTTCAGGCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGCTACTCGCCGCTGACCACG
CTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACGACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTT
CAATGTCTGTCCTGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGAGCAGAACAGAGCTTCACGATCCCCATCCCTGAACAACCAGAC
CTCTTCATTCCACATCTAATTCAAAGGATGAACAGACTCTTCATTTATTCATTCTGCAAACTCCCCCTCCCCTCCTCTGTGCCTAGACAT
GGCTAGAATCCCAGAAGGGCCTTTATTTTCAGGCATAGACTCCTCTGTGGTCACAGCTGGAGCACAGAGAGGGACCCTGGGAACTTGGCC
TGGGAAGCCCAGAGCAGGAAGCCACAGCTGTCTCTGGGAAAGCAAGGGAGGCTTCCTGGAGGAAGCGGCATTGTTATGAGCCTTGAAGGA
AGAGACAGACTCTGCTACATTCAACCTCGTGACTTCATGATCCTGGGCCTGAGAACACAGGAATGATTCATAGCCCACCCCCCACCTCCA
TGCATACACCAGAGCTCTGTGGACCAAGGGGTCATTCCTGGTCACACACTCCATCAGCAAAATGTATTTGAGCACACACCAGCAATGTAT

>15634_15634_3_CELF5-RDH8_CELF5_chr19_3224996_ENST00000541430_RDH8_chr19_10127733_ENST00000171214_length(amino acids)=395AA_BP=0
MWNEEVWLFRDGDREALFCSSWPHPRWEAAAGQTLKAKVEEAWTAEEEAVGRSHIQAARGIHGFERGQRRVADVGLSAQGWSSRADDVDN
GLNHVLWVLSHGAKQLPGGWEIEVPEVVQGLRVSAWELSHRNLRQKLPLKLGDHGAWLHQGDEDVELQQLDSEAFEESLQGELGSCIDIV
EDDTLQAHDTADHHDVALPPPLHAWKHSFDETDSSEKVGVKDILHGSKAEPLQGPHQAHSSIIHQHVHFSLDTAETLGHRLITAHVQLGH
GEGLPQSLPSSCLQCLLLPQVPHGGHDFVHPRVGVFEHRELVDAAELLEERLEVLLVQVPRDLAHEEFDGVQVLHAVGLPPGGLGPAAAH

--------------------------------------------------------------
>15634_15634_4_CELF5-RDH8_CELF5_chr19_3224996_ENST00000541430_RDH8_chr19_10127733_ENST00000591589_length(transcript)=1658nt_BP=295nt
CGCCGCCGCCGCCGCCGGCTCGGTCCCGCGCCCGCCATGGCCCGCCTGACGGAGAGCGAGGCGCGCCGGCAGCAGCAGCAGCTCCTGCAG
CCGCGGCCCTCGCCCGTGGGCAGCAGCGGGCCCGAGCCCCCCGGGGGGCAGCCCGACGGCATGAAGGACCTGGACGCCATCAAACTCTTC
GTGGGCCAGATCCCGCGGCACCTGGACGAGAAGGACCTCAAGCCGCTCTTCGAGCAGTTCGGCCGCATCTACGAGCTCACGGTGCTCAAA
GACCCCTACACGGGGATGCACAAAGTCGTGGCCACCATGAGGGACCTGGGGAAGAAGGAGACACTGGAGGCAGCTGCTGGGGAGGCTCTG
GGGCAGACCCTCACCGTGGCCCAGCTGGACGTGTGCAGTGATGAGTCGGTGGCCCAGTGTCTCAGCTGTATCCAGGGAGAAGTGGACGTG
CTGGTGAATAATGCTGGAATGGGCCTGGTGGGGCCCCTGGAGGGGCTCAGCCTTGCTGCCATGCAGAATGTCTTTGACACCAACTTTTTC
GGAGCTGTCCGTCTCGTCAAAGCTGTGCTTCCAGGCATGAAGAGGAGGCGGCAGGGCCACATCGTGGTGATCAGCAGTGTCATGGGCCTG
CAGGGTGTCATCTTCAACGATGTCTATGCAGCTTCCAAGTTCGCCCTGGAGGGATTCTTCGAAAGCCTCGCTATCCAGCTGCTGCAGTTC
AACATCTTCATCTCCCTGGTGGAGCCAGGCCCCGTGGTCACCGAGTTTGAGGGGAAGCTTCTGGCGCAGGTTTCTATGGCTGAGTTCCCA
GGCACTGACCCTGAGACCCTGCACTACTTCCGGGACCTCTATCTCCCAGCCTCCAGGAAGCTGTTTTGCTCCGTGGGACAGAACCCACAG
GACGTGGTTCAGGCCATTGTCAACGTCATCAGCTCGACTCGACCACCCCTGCGCCGACAGACCAACATCCGCTACTCGCCGCTGACCACG
CTCAAAACCGTGGATTCCTCTGGCAGCCTGTATGTGCGAACGACCCACCGCCTCCTCTTCCGCTGTCCACGCCTCCTCAACCTTGGCCTT
CAATGTCTGTCCTGCGGCTGCCTCCCAACGCGGGTGCGGCCAAGATGAGCAGAACAGAGCTTCACGATCCCCATCCCTGAACAACCAGAC
CTCTTCATTCCACATCTAATTCAAAGGATGAACAGACTCTTCATTTATTCATTCTGCAAACTCCCCCTCCCCTCCTCTGTGCCTAGACAT
GGCTAGAATCCCAGAAGGGCCTTTATTTTCAGGCATAGACTCCTCTGTGGTCACAGCTGGAGCACAGAGAGGGACCCTGGGAACTTGGCC
TGGGAAGCCCAGAGCAGGAAGCCACAGCTGTCTCTGGGAAAGCAAGGGAGGCTTCCTGGAGGAAGCGGCATTGTTATGAGCCTTGAAGGA
AGAGACAGACTCTGCTACATTCAACCTCGTGACTTCATGATCCTGGGCCTGAGAACACAGGAATGATTCATAGCCCACCCCCCACCTCCA
TGCATACACCAGAGCTCTGTGGACCAAGGGGTCATTCCTGGTCACACACTCCATCAGCAAAATGTATTTGAGCACACACCAGCAATGTAT

>15634_15634_4_CELF5-RDH8_CELF5_chr19_3224996_ENST00000541430_RDH8_chr19_10127733_ENST00000591589_length(amino acids)=363AA_BP=86
MARLTESEARRQQQQLLQPRPSPVGSSGPEPPGGQPDGMKDLDAIKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKVVAT
MRDLGKKETLEAAAGEALGQTLTVAQLDVCSDESVAQCLSCIQGEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFGAVRLVKAVLPG
MKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFISLVEPGPVVTEFEGKLLAQVSMAEFPGTDPETLHYFRD
LYLPASRKLFCSVGQNPQDVVQAIVNVISSTRPPLRRQTNIRYSPLTTLKTVDSSGSLYVRTTHRLLFRCPRLLNLGLQCLSCGCLPTRV

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Fusion Gene PPI Analysis for CELF5-RDH8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CELF5-RDH8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CELF5-RDH8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource