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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CELSR1-FLOT1 (FusionGDB2 ID:15646)

Fusion Gene Summary for CELSR1-FLOT1

check button Fusion gene summary
Fusion gene informationFusion gene name: CELSR1-FLOT1
Fusion gene ID: 15646
HgeneTgene
Gene symbol

CELSR1

FLOT1

Gene ID

9620

10211

Gene namecadherin EGF LAG seven-pass G-type receptor 1flotillin 1
SynonymsADGRC1|CDHF9|FMI2|HFMI2|ME2-
Cytomap

22q13.31

6p21.33

Type of geneprotein-codingprotein-coding
Descriptioncadherin EGF LAG seven-pass G-type receptor 1adhesion G protein-coupled receptor C1cadherin family member 9cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)flamingo homolog 2protocadherin flamingo 2flotillin-1integral membrane component of caveolae
Modification date2020032220200322
UniProtAcc

Q9NYQ6

O75955

Ensembl transtripts involved in fusion geneENST00000262738, ENST00000395964, 
ENST00000497509, 		ENST00000383382, 
ENST00000383562, ENST00000420604, 
ENST00000430843, ENST00000436822, 
ENST00000444632, ENST00000460694, 
ENST00000466680, ENST00000470163, 
ENST00000470643, ENST00000490802, 
ENST00000492441, ENST00000496175, 
ENST00000553223, ENST00000376389, 
ENST00000456573, 
Fusion gene scores* DoF score23 X 19 X 11=48077 X 6 X 4=168
# samples 287
** MAII scorelog2(28/4807*10)=-4.10163807119293
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CELSR1 [Title/Abstract] AND FLOT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCELSR1(46804892)-FLOT1(30698877), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFLOT1

GO:0051580

regulation of neurotransmitter uptake

21399631


check buttonFusion gene breakpoints across CELSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FLOT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1695CELSR1chr22

46804892

-FLOT1chr6

30698877

-


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Fusion Gene ORF analysis for CELSR1-FLOT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262738ENST00000383382CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000383562CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000420604CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000430843CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000436822CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000444632CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000460694CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000466680CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000470163CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000470643CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000490802CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000492441CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000496175CELSR1chr22

46804892

-FLOT1chr6

30698877

-
5CDS-intronENST00000262738ENST00000553223CELSR1chr22

46804892

-FLOT1chr6

30698877

-
In-frameENST00000262738ENST00000376389CELSR1chr22

46804892

-FLOT1chr6

30698877

-
In-frameENST00000262738ENST00000456573CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-3CDSENST00000395964ENST00000376389CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-3CDSENST00000395964ENST00000456573CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-3CDSENST00000497509ENST00000376389CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-3CDSENST00000497509ENST00000456573CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000383382CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000383562CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000420604CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000430843CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000436822CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000444632CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000460694CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000466680CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000470163CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000470643CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000490802CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000492441CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000496175CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000395964ENST00000553223CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000383382CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000383562CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000420604CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000430843CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000436822CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000444632CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000460694CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000466680CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000470163CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000470643CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000490802CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000492441CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000496175CELSR1chr22

46804892

-FLOT1chr6

30698877

-
intron-intronENST00000497509ENST00000553223CELSR1chr22

46804892

-FLOT1chr6

30698877

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262738CELSR1chr2246804892-ENST00000376389FLOT1chr630698877-61945226057861928
ENST00000262738CELSR1chr2246804892-ENST00000456573FLOT1chr630698877-58545226057861928

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262738ENST00000376389CELSR1chr2246804892-FLOT1chr630698877-0.0018090380.99819094
ENST00000262738ENST00000456573CELSR1chr2246804892-FLOT1chr630698877-0.0021645310.99783546

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Fusion Genomic Features for CELSR1-FLOT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CELSR1-FLOT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46804892/chr6:30698877)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELSR1

Q9NYQ6

FLOT1

O75955

FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351000_110117423015.0DomainCadherin 8
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351106_122417423015.0DomainCadherin 9
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351303_136117423015.0DomainEGF-like 1%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351363_139917423015.0DomainEGF-like 2%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351403_144117423015.0DomainEGF-like 3%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351442_164617423015.0DomainLaminin G-like 1
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351649_168517423015.0DomainEGF-like 4%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935246_35317423015.0DomainCadherin 1
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935354_45917423015.0DomainCadherin 2
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935460_56517423015.0DomainCadherin 3
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935566_68717423015.0DomainCadherin 4
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935688_78917423015.0DomainCadherin 5
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935790_89217423015.0DomainCadherin 6
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-935893_99917423015.0DomainCadherin 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352659_266317423015.0Compositional biasNote=Poly-Leu
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351689_187017423015.0DomainLaminin G-like 2
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351872_190717423015.0DomainEGF-like 5%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351908_194617423015.0DomainEGF-like 6%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351947_197917423015.0DomainEGF-like 7%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9351981_201617423015.0DomainEGF-like 8%3B calcium-binding
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352003_205017423015.0DomainLaminin EGF-like
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352408_246017423015.0DomainGPS
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-93522_246917423015.0Topological domainExtracellular
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352491_250117423015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352523_252717423015.0Topological domainExtracellular
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352549_257217423015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352594_261117423015.0Topological domainExtracellular
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352633_265517423015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352677_268317423015.0Topological domainExtracellular
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352705_301417423015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352470_249017423015.0TransmembraneHelical%3B Name%3D1
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352502_252217423015.0TransmembraneHelical%3B Name%3D2
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352528_254817423015.0TransmembraneHelical%3B Name%3D3
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352573_259317423015.0TransmembraneHelical%3B Name%3D4
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352612_263217423015.0TransmembraneHelical%3B Name%3D5
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352656_267617423015.0TransmembraneHelical%3B Name%3D6
HgeneCELSR1chr22:46804892chr6:30698877ENST00000262738-9352684_270417423015.0TransmembraneHelical%3B Name%3D7


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Fusion Gene Sequence for CELSR1-FLOT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15646_15646_1_CELSR1-FLOT1_CELSR1_chr22_46804892_ENST00000262738_FLOT1_chr6_30698877_ENST00000376389_length(transcript)=6194nt_BP=5226nt
ATGGCGCCGCCGCCGCCGCCCGTGCTGCCCGTGCTGCTGCTCCTGGCCGCCGCCGCCGCCCTGCCGGCGATGGGGCTGCGAGCGGCCGCC
TGGGAGCCGCGCGTACCCGGCGGGACCCGCGCCTTCGCCCTCCGGCCCGGCTGTACCTACGCGGTGGGCGCCGCTTGCACGCCCCGGGCG
CCGCGGGAGCTGCTGGACGTGGGCCGCGATGGGCGGCTGGCAGGACGTCGGCGCGTCTCGGGCGCGGGGCGCCCGCTGCCGCTGCAAGTC
CGCTTGGTGGCCCGCAGTGCCCCGACGGCGCTGAGCCGCCGCCTGCGGGCGCGCACGCACCTTCCCGGCTGCGGAGCCCGTGCCCGGCTC
TGCGGAACCGGTGCCCGGCTCTGCGGGGCGCTCTGCTTCCCCGTCCCCGGCGGCTGCGCGGCCGCGCAGCATTCGGCGCTCGCAGCTCCG
ACCACCTTACCCGCCTGCCGCTGCCCGCCGCGCCCCAGGCCCCGCTGTCCCGGCCGTCCCATCTGCCTGCCGCCGGGCGGCTCGGTCCGC
CTGCGTCTGCTGTGCGCCCTGCGGCGCGCGGCTGGCGCCGTCCGGGTGGGACTGGCGCTGGAGGCCGCCACCGCGGGGACGCCCTCCGCG
TCGCCATCCCCATCGCCGCCCCTGCCGCCGAACTTGCCCGAAGCCCGGGCGGGGCCGGCGCGACGGGCCCGGCGGGGCACGAGCGGCAGA
GGGAGCCTGAAGTTTCCGATGCCCAACTACCAGGTGGCGTTGTTTGAGAACGAACCGGCGGGCACCCTCATCCTCCAGCTGCACGCGCAC
TACACCATCGAGGGCGAGGAGGAGCGCGTGAGCTATTACATGGAGGGGCTGTTCGACGAGCGCTCCCGGGGCTACTTCCGAATCGACTCT
GCCACGGGCGCCGTGAGCACGGACAGCGTACTGGACCGCGAGACCAAGGAGACGCACGTCCTCAGGGTGAAAGCCGTGGACTACAGTACG
CCGCCGCGCTCGGCCACCACCTACATCACTGTCTTGGTCAAAGACACCAACGACCACAGCCCGGTCTTCGAGCAGTCGGAGTACCGCGAG
CGCGTGCGGGAGAACCTGGAGGTGGGCTACGAGGTGCTGACCATCCGCGCCAGCGACCGCGACTCGCCCATCAACGCCAACTTGCGTTAC
CGCGTGTTGGGGGGCGCGTGGGACGTCTTCCAGCTCAACGAGAGCTCTGGCGTGGTGAGCACACGGGCGGTGCTGGACCGGGAGGAGGCG
GCCGAGTACCAGCTCCTGGTGGAGGCCAACGACCAGGGGCGCAATCCGGGCCCGCTCAGTGCCACGGCCACCGTGTACATCGAGGTGGAG
GACGAGAACGACAACTACCCCCAGTTCAGCGAGCAGAACTACGTGGTCCAGGTGCCCGAGGACGTGGGGCTCAACACGGCTGTGCTGCGA
GTGCAGGCCACGGACCGGGACCAGGGCCAGAACGCGGCCATTCACTACAGCATCCTCAGCGGGAACGTGGCCGGCCAGTTCTACCTGCAC
TCGCTGAGCGGGATCCTGGATGTGATCAACCCCTTGGATTTCGAGGATGTCCAGAAATACTCGCTGAGCATTAAGGCCCAGGATGGGGGC
CGGCCCCCGCTCATCAATTCTTCAGGGGTGGTGTCTGTGCAGGTGCTGGATGTCAACGACAACGAGCCTATCTTTGTGAGCAGCCCCTTC
CAGGCCACGGTGCTGGAGAATGTGCCCCTGGGCTACCCCGTGGTGCACATTCAGGCGGTGGACGCGGACTCTGGAGAGAACGCCCGGCTG
CACTATCGCCTGGTGGACACGGCCTCCACCTTTCTGGGGGGCGGCAGCGCTGGGCCTAAGAATCCTGCCCCCACCCCTGACTTCCCCTTC
CAGATCCACAACAGCTCCGGTTGGATCACAGTGTGTGCCGAGCTGGACCGCGAGGAGGTGGAGCACTACAGCTTCGGGGTGGAGGCGGTG
GACCACGGCTCGCCCCCCATGAGCTCCTCCACCAGCGTGTCCATCACGGTGCTGGACGTGAATGACAACGACCCGGTGTTCACGCAGCCC
ACCTACGAGCTTCGTCTGAATGAGGATGCGGCCGTGGGGAGCAGCGTGCTGACCCTGCAGGCCCGCGACCGTGACGCCAACAGTGTGATT
ACCTACCAGCTCACAGGCGGCAACACCCGGAACCGCTTTGCACTCAGCAGCCAGAGAGGGGGCGGCCTCATCACCCTGGCGCTACCTCTG
GACTACAAGCAGGAGCAGCAGTACGTGCTGGCGGTGACAGCATCCGACGGCACACGGTCGCACACTGCGCATGTCCTAATCAACGTCACT
GATGCCAACACCCACAGGCCTGTCTTTCAGAGCTCCCATTACACAGTGAGTGTCAGTGAGGACAGGCCTGTGGGCACCTCCATTGCTACC
CTCAGTGCCAACGATGAGGACACAGGAGAGAATGCCCGCATCACCTACGTGATTCAGGACCCCGTGCCGCAGTTCCGCATTGACCCCGAC
AGTGGCACCATGTACACCATGATGGAGCTGGACTATGAGAACCAGGTCGCCTACACGCTGACCATCATGGCCCAGGACAACGGCATCCCG
CAGAAATCAGACACCACCACCCTAGAGATCCTCATCCTCGATGCCAATGACAATGCACCCCAGTTCCTGTGGGATTTCTACCAGGGTTCC
ATCTTTGAGGATGCTCCACCCTCGACCAGCATCCTCCAGGTCTCTGCCACGGACCGGGACTCAGGTCCCAATGGGCGTCTGCTGTACACC
TTCCAGGGTGGGGACGACGGCGATGGGGACTTCTACATCGAGCCCACGTCCGGTGTGATTCGCACCCAGCGCCGGCTGGACCGGGAGAAT
GTGGCCGTGTACAACCTTTGGGCTCTGGCTGTGGATCGGGGCAGTCCCACTCCCCTTAGCGCCTCGGTAGAAATCCAGGTGACCATCTTG
GACATTAATGACAATGCCCCCATGTTTGAGAAGGACGAACTGGAGCTGTTTGTTGAGGAGAACAACCCAGTGGGGTCGGTGGTGGCAAAG
ATTCGTGCTAACGACCCTGATGAAGGCCCTAATGCCCAGATCATGTATCAGATTGTGGAAGGGGACATGCGGCATTTCTTCCAGCTGGAC
CTGCTCAACGGGGACCTGCGTGCCATGGTGGAGCTGGACTTTGAGGTCCGGCGGGAGTATGTGCTGGTGGTGCAGGCCACGTCGGCTCCG
CTGGTGAGCCGAGCCACGGTGCACATCCTTCTCGTGGACCAGAATGACAACCCGCCTGTGCTGCCCGACTTCCAGATCCTCTTCAACAAC
TATGTCACCAACAAGTCCAACAGTTTCCCCACCGGCGTGATCGGCTGCATCCCGGCCCATGACCCCGACGTGTCAGACAGCCTCAACTAC
ACCTTCGTGCAGGGCAACGAGCTGCGCCTGTTGCTGCTGGACCCCGCCACGGGCGAACTGCAGCTCAGCCGCGACCTGGACAACAACCGG
CCGCTGGAGGCGCTCATGGAGGTGTCTGTGTCTGATGGCATCCACAGCGTCACGGCCTTCTGCACCCTGCGTGTCACCATCATCACGGAC
GACATGCTGACCAACAGCATCACTGTCCGCCTGGAGAACATGTCCCAGGAGAAGTTCCTGTCCCCGCTGCTGGCCCTCTTCGTGGAGGGG
GTGGCCGCCGTGCTGTCCACCACCAAGGACGACGTCTTCGTCTTCAACGTCCAGAACGACACCGACGTCAGCTCCAACATCCTGAACGTG
ACCTTCTCGGCGCTGCTGCCTGGCGGCGTCCGCGGCCAGTTCTTCCCGTCGGAGGACCTGCAGGAGCAGATCTACCTGAATCGGACGCTG
CTGACCACCATCTCCACGCAGCGCGTGCTGCCCTTCGACGACAACATCTGCCTGCGCGAGCCCTGCGAGAACTACATGAAGTGCGTGTCC
GTTCTGCGATTCGACAGCTCCGCGCCCTTCCTCAGCTCCACCACCGTGCTCTTCCGGCCCATCCACCCCATCAACGGCCTGCGCTGCCGC
TGCCCGCCCGGCTTCACCGGCGACTACTGCGAGACGGAGATCGACCTCTGCTACTCCGACCCGTGCGGCGCCAACGGCCGCTGCCGCAGC
CGCGAGGGCGGCTACACCTGCGAGTGCTTCGAGGACTTCACTGGAGAGCACTGTGAGGTGGATGCCCGCTCAGGCCGCTGTGCCAACGGG
GTGTGCAAGAACGGGGGCACCTGCGTGAACCTGCTCATCGGCGGCTTCCACTGCGTGTGTCCTCCTGGCGAGTATGAGAGGCCCTACTGT
GAGGTGACCACCAGGAGCTTCCCGCCCCAGTCCTTCGTCACCTTCCGGGGCCTGAGACAGCGCTTCCACTTCACCATCTCCCTCACGTTT
GCCACTCAGGAAAGGAACGGCTTGCTTCTCTACAACGGCCGCTTCAATGAGAAGCACGACTTCATCGCCCTGGAGATCGTGGACGAGCAG
GTGCAGCTCACCTTCTCTGCAGGCGAGACAACAACGACCGTGGCACCGAAGGTTCCCAGTGGTGTGAGTGACGGGCGGTGGCACTCTGTG
CAGGTGCAGTACTACAACAAGCCCAATATTGGCCACCTGGGCCTGCCCCATGGGCCGTCCGGGGAAAAGATGGCCGTGGTGACAGTGGAT
GATTGTGACACAACCATGGCTGTGCGCTTTGGAAAGGACATCGGGAACTACAGCTGCGCTGCCCAGGGCACTCAGACCGGCTCCAAGAAG
TCCCTGGATCTGACCGGCCCTCTACTCCTGGGGGGTGTCCCCAACCTGCCAGAAGACTTCCCAGTGCACAACCGGCAGTTCGTGGGCTGC
ATGCGGAACCTGTCAGTCGACGGCAAAAATGTGGACATGGCCGGATTCATCGCCAACAATGGCACCCGGGAAGGCTGCGCTGCTCGGAGG
AACTTCTGCGATGGGAGGCGGTGTCAGAATGGAGGCACCTGTGTCAACAGGTGGAATATGTATCTGTGTGAGTGTCCACTCCGATTCGGC
GGGAAGAACTGTGAGCAAGCCATGCCTCACCCCCAGCTCTTCAGCGGTGAGAGCGTCGTGTCCTGGAGTGACCTGAACATCATCATCTCT
GTGCCCTGGTACCTGGGGCTCATGTTCCGGACCCGGAAGGAGGACAGCGTTCTGATGGAGGCCACCAGTGGTGGGCCCACCAGCTTTCGC
CTCCAGGTGGCCAAGACTAAGCAGCAGATTGAGGAGCAGCGGGTGCAGGTGCAGGTGGTGGAGCGGGCCCAGCAGGTGGCAGTGCAGGAG
CAGGAGATCGCCCGGCGGGAGAAGGAGCTGGAGGCCCGGGTGCGGAAGCCAGCGGAAGCGGAGCGCTACAAGCTGGAGCGCCTAGCCGAG
GCAGAGAAGTCCCAACTAATTATGCAGGCGGAGGCAGAAGCCGCGTCTGTGCGGATGCGTGGGGAAGCTGAGGCCTTTGCCATAGGGGCC
CGAGCCCGAGCCGAGGCTGAGCAGATGGCCAAGAAGGCAGAAGCCTTCCAGCTGTACCAAGAGGCTGCTCAGCTGGACATGCTGCTAGAG
AAGCTGCCCCAGGTGGCAGAGGAGATCAGTGGTCCCTTGACTTCAGCCAATAAGATCACACTGGTGTCCAGCGGCAGTGGGACCATGGGG
GCAGCCAAAGTGACTGGGGAAGTACTGGACATTCTAACTCGCCTGCCAGAGAGTGTGGAAAGACTCACAGGCGTGAGCATCTCCCAGGTG
AATCACAAGCCTTTGAGAACAGCCTGAGCCTTCAGCCCTCACAGATGCCCAGCCTCATAGCTGAAGTTGCCTGAATGATCCTCCTGTTGC
ATGTAACCCACTGGCCTCCCTGAGCATGTCCATTGACAGTGAGGTCCCACCCCTCATCTCTCCTTGCCAAATAGTTTGTGCCTTGTCTTG
AAGGGGGTTGCTCCCCTTGCCAACCTCACACTGCTATGATTGCCAACTCCAGCGGTCCCATGTCAGCCTTCTGATGATCCCACTCCACCC
CACCTCAACTTATTTAACTTCCTAATTAAATCAGACTGTTTGAGCCTGTTGTCTAGAATATTTTCCTGACCAAGACTGAGGGATGGGCTG

>15646_15646_1_CELSR1-FLOT1_CELSR1_chr22_46804892_ENST00000262738_FLOT1_chr6_30698877_ENST00000376389_length(amino acids)=1928AA_BP=1741
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQV
RLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAH
YTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVE
DENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPF
QIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT
LSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTIL
DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR
PLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCR
CPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSV
QVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC
MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIIS
VPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAE
AEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMG

--------------------------------------------------------------
>15646_15646_2_CELSR1-FLOT1_CELSR1_chr22_46804892_ENST00000262738_FLOT1_chr6_30698877_ENST00000456573_length(transcript)=5854nt_BP=5226nt
ATGGCGCCGCCGCCGCCGCCCGTGCTGCCCGTGCTGCTGCTCCTGGCCGCCGCCGCCGCCCTGCCGGCGATGGGGCTGCGAGCGGCCGCC
TGGGAGCCGCGCGTACCCGGCGGGACCCGCGCCTTCGCCCTCCGGCCCGGCTGTACCTACGCGGTGGGCGCCGCTTGCACGCCCCGGGCG
CCGCGGGAGCTGCTGGACGTGGGCCGCGATGGGCGGCTGGCAGGACGTCGGCGCGTCTCGGGCGCGGGGCGCCCGCTGCCGCTGCAAGTC
CGCTTGGTGGCCCGCAGTGCCCCGACGGCGCTGAGCCGCCGCCTGCGGGCGCGCACGCACCTTCCCGGCTGCGGAGCCCGTGCCCGGCTC
TGCGGAACCGGTGCCCGGCTCTGCGGGGCGCTCTGCTTCCCCGTCCCCGGCGGCTGCGCGGCCGCGCAGCATTCGGCGCTCGCAGCTCCG
ACCACCTTACCCGCCTGCCGCTGCCCGCCGCGCCCCAGGCCCCGCTGTCCCGGCCGTCCCATCTGCCTGCCGCCGGGCGGCTCGGTCCGC
CTGCGTCTGCTGTGCGCCCTGCGGCGCGCGGCTGGCGCCGTCCGGGTGGGACTGGCGCTGGAGGCCGCCACCGCGGGGACGCCCTCCGCG
TCGCCATCCCCATCGCCGCCCCTGCCGCCGAACTTGCCCGAAGCCCGGGCGGGGCCGGCGCGACGGGCCCGGCGGGGCACGAGCGGCAGA
GGGAGCCTGAAGTTTCCGATGCCCAACTACCAGGTGGCGTTGTTTGAGAACGAACCGGCGGGCACCCTCATCCTCCAGCTGCACGCGCAC
TACACCATCGAGGGCGAGGAGGAGCGCGTGAGCTATTACATGGAGGGGCTGTTCGACGAGCGCTCCCGGGGCTACTTCCGAATCGACTCT
GCCACGGGCGCCGTGAGCACGGACAGCGTACTGGACCGCGAGACCAAGGAGACGCACGTCCTCAGGGTGAAAGCCGTGGACTACAGTACG
CCGCCGCGCTCGGCCACCACCTACATCACTGTCTTGGTCAAAGACACCAACGACCACAGCCCGGTCTTCGAGCAGTCGGAGTACCGCGAG
CGCGTGCGGGAGAACCTGGAGGTGGGCTACGAGGTGCTGACCATCCGCGCCAGCGACCGCGACTCGCCCATCAACGCCAACTTGCGTTAC
CGCGTGTTGGGGGGCGCGTGGGACGTCTTCCAGCTCAACGAGAGCTCTGGCGTGGTGAGCACACGGGCGGTGCTGGACCGGGAGGAGGCG
GCCGAGTACCAGCTCCTGGTGGAGGCCAACGACCAGGGGCGCAATCCGGGCCCGCTCAGTGCCACGGCCACCGTGTACATCGAGGTGGAG
GACGAGAACGACAACTACCCCCAGTTCAGCGAGCAGAACTACGTGGTCCAGGTGCCCGAGGACGTGGGGCTCAACACGGCTGTGCTGCGA
GTGCAGGCCACGGACCGGGACCAGGGCCAGAACGCGGCCATTCACTACAGCATCCTCAGCGGGAACGTGGCCGGCCAGTTCTACCTGCAC
TCGCTGAGCGGGATCCTGGATGTGATCAACCCCTTGGATTTCGAGGATGTCCAGAAATACTCGCTGAGCATTAAGGCCCAGGATGGGGGC
CGGCCCCCGCTCATCAATTCTTCAGGGGTGGTGTCTGTGCAGGTGCTGGATGTCAACGACAACGAGCCTATCTTTGTGAGCAGCCCCTTC
CAGGCCACGGTGCTGGAGAATGTGCCCCTGGGCTACCCCGTGGTGCACATTCAGGCGGTGGACGCGGACTCTGGAGAGAACGCCCGGCTG
CACTATCGCCTGGTGGACACGGCCTCCACCTTTCTGGGGGGCGGCAGCGCTGGGCCTAAGAATCCTGCCCCCACCCCTGACTTCCCCTTC
CAGATCCACAACAGCTCCGGTTGGATCACAGTGTGTGCCGAGCTGGACCGCGAGGAGGTGGAGCACTACAGCTTCGGGGTGGAGGCGGTG
GACCACGGCTCGCCCCCCATGAGCTCCTCCACCAGCGTGTCCATCACGGTGCTGGACGTGAATGACAACGACCCGGTGTTCACGCAGCCC
ACCTACGAGCTTCGTCTGAATGAGGATGCGGCCGTGGGGAGCAGCGTGCTGACCCTGCAGGCCCGCGACCGTGACGCCAACAGTGTGATT
ACCTACCAGCTCACAGGCGGCAACACCCGGAACCGCTTTGCACTCAGCAGCCAGAGAGGGGGCGGCCTCATCACCCTGGCGCTACCTCTG
GACTACAAGCAGGAGCAGCAGTACGTGCTGGCGGTGACAGCATCCGACGGCACACGGTCGCACACTGCGCATGTCCTAATCAACGTCACT
GATGCCAACACCCACAGGCCTGTCTTTCAGAGCTCCCATTACACAGTGAGTGTCAGTGAGGACAGGCCTGTGGGCACCTCCATTGCTACC
CTCAGTGCCAACGATGAGGACACAGGAGAGAATGCCCGCATCACCTACGTGATTCAGGACCCCGTGCCGCAGTTCCGCATTGACCCCGAC
AGTGGCACCATGTACACCATGATGGAGCTGGACTATGAGAACCAGGTCGCCTACACGCTGACCATCATGGCCCAGGACAACGGCATCCCG
CAGAAATCAGACACCACCACCCTAGAGATCCTCATCCTCGATGCCAATGACAATGCACCCCAGTTCCTGTGGGATTTCTACCAGGGTTCC
ATCTTTGAGGATGCTCCACCCTCGACCAGCATCCTCCAGGTCTCTGCCACGGACCGGGACTCAGGTCCCAATGGGCGTCTGCTGTACACC
TTCCAGGGTGGGGACGACGGCGATGGGGACTTCTACATCGAGCCCACGTCCGGTGTGATTCGCACCCAGCGCCGGCTGGACCGGGAGAAT
GTGGCCGTGTACAACCTTTGGGCTCTGGCTGTGGATCGGGGCAGTCCCACTCCCCTTAGCGCCTCGGTAGAAATCCAGGTGACCATCTTG
GACATTAATGACAATGCCCCCATGTTTGAGAAGGACGAACTGGAGCTGTTTGTTGAGGAGAACAACCCAGTGGGGTCGGTGGTGGCAAAG
ATTCGTGCTAACGACCCTGATGAAGGCCCTAATGCCCAGATCATGTATCAGATTGTGGAAGGGGACATGCGGCATTTCTTCCAGCTGGAC
CTGCTCAACGGGGACCTGCGTGCCATGGTGGAGCTGGACTTTGAGGTCCGGCGGGAGTATGTGCTGGTGGTGCAGGCCACGTCGGCTCCG
CTGGTGAGCCGAGCCACGGTGCACATCCTTCTCGTGGACCAGAATGACAACCCGCCTGTGCTGCCCGACTTCCAGATCCTCTTCAACAAC
TATGTCACCAACAAGTCCAACAGTTTCCCCACCGGCGTGATCGGCTGCATCCCGGCCCATGACCCCGACGTGTCAGACAGCCTCAACTAC
ACCTTCGTGCAGGGCAACGAGCTGCGCCTGTTGCTGCTGGACCCCGCCACGGGCGAACTGCAGCTCAGCCGCGACCTGGACAACAACCGG
CCGCTGGAGGCGCTCATGGAGGTGTCTGTGTCTGATGGCATCCACAGCGTCACGGCCTTCTGCACCCTGCGTGTCACCATCATCACGGAC
GACATGCTGACCAACAGCATCACTGTCCGCCTGGAGAACATGTCCCAGGAGAAGTTCCTGTCCCCGCTGCTGGCCCTCTTCGTGGAGGGG
GTGGCCGCCGTGCTGTCCACCACCAAGGACGACGTCTTCGTCTTCAACGTCCAGAACGACACCGACGTCAGCTCCAACATCCTGAACGTG
ACCTTCTCGGCGCTGCTGCCTGGCGGCGTCCGCGGCCAGTTCTTCCCGTCGGAGGACCTGCAGGAGCAGATCTACCTGAATCGGACGCTG
CTGACCACCATCTCCACGCAGCGCGTGCTGCCCTTCGACGACAACATCTGCCTGCGCGAGCCCTGCGAGAACTACATGAAGTGCGTGTCC
GTTCTGCGATTCGACAGCTCCGCGCCCTTCCTCAGCTCCACCACCGTGCTCTTCCGGCCCATCCACCCCATCAACGGCCTGCGCTGCCGC
TGCCCGCCCGGCTTCACCGGCGACTACTGCGAGACGGAGATCGACCTCTGCTACTCCGACCCGTGCGGCGCCAACGGCCGCTGCCGCAGC
CGCGAGGGCGGCTACACCTGCGAGTGCTTCGAGGACTTCACTGGAGAGCACTGTGAGGTGGATGCCCGCTCAGGCCGCTGTGCCAACGGG
GTGTGCAAGAACGGGGGCACCTGCGTGAACCTGCTCATCGGCGGCTTCCACTGCGTGTGTCCTCCTGGCGAGTATGAGAGGCCCTACTGT
GAGGTGACCACCAGGAGCTTCCCGCCCCAGTCCTTCGTCACCTTCCGGGGCCTGAGACAGCGCTTCCACTTCACCATCTCCCTCACGTTT
GCCACTCAGGAAAGGAACGGCTTGCTTCTCTACAACGGCCGCTTCAATGAGAAGCACGACTTCATCGCCCTGGAGATCGTGGACGAGCAG
GTGCAGCTCACCTTCTCTGCAGGCGAGACAACAACGACCGTGGCACCGAAGGTTCCCAGTGGTGTGAGTGACGGGCGGTGGCACTCTGTG
CAGGTGCAGTACTACAACAAGCCCAATATTGGCCACCTGGGCCTGCCCCATGGGCCGTCCGGGGAAAAGATGGCCGTGGTGACAGTGGAT
GATTGTGACACAACCATGGCTGTGCGCTTTGGAAAGGACATCGGGAACTACAGCTGCGCTGCCCAGGGCACTCAGACCGGCTCCAAGAAG
TCCCTGGATCTGACCGGCCCTCTACTCCTGGGGGGTGTCCCCAACCTGCCAGAAGACTTCCCAGTGCACAACCGGCAGTTCGTGGGCTGC
ATGCGGAACCTGTCAGTCGACGGCAAAAATGTGGACATGGCCGGATTCATCGCCAACAATGGCACCCGGGAAGGCTGCGCTGCTCGGAGG
AACTTCTGCGATGGGAGGCGGTGTCAGAATGGAGGCACCTGTGTCAACAGGTGGAATATGTATCTGTGTGAGTGTCCACTCCGATTCGGC
GGGAAGAACTGTGAGCAAGCCATGCCTCACCCCCAGCTCTTCAGCGGTGAGAGCGTCGTGTCCTGGAGTGACCTGAACATCATCATCTCT
GTGCCCTGGTACCTGGGGCTCATGTTCCGGACCCGGAAGGAGGACAGCGTTCTGATGGAGGCCACCAGTGGTGGGCCCACCAGCTTTCGC
CTCCAGGTGGCCAAGACTAAGCAGCAGATTGAGGAGCAGCGGGTGCAGGTGCAGGTGGTGGAGCGGGCCCAGCAGGTGGCAGTGCAGGAG
CAGGAGATCGCCCGGCGGGAGAAGGAGCTGGAGGCCCGGGTGCGGAAGCCAGCGGAAGCGGAGCGCTACAAGCTGGAGCGCCTAGCCGAG
GCAGAGAAGTCCCAACTAATTATGCAGGCGGAGGCAGAAGCCGCGTCTGTGCGGATGCGTGGGGAAGCTGAGGCCTTTGCCATAGGGGCC
CGAGCCCGAGCCGAGGCTGAGCAGATGGCCAAGAAGGCAGAAGCCTTCCAGCTGTACCAAGAGGCTGCTCAGCTGGACATGCTGCTAGAG
AAGCTGCCCCAGGTGGCAGAGGAGATCAGTGGTCCCTTGACTTCAGCCAATAAGATCACACTGGTGTCCAGCGGCAGTGGGACCATGGGG
GCAGCCAAAGTGACTGGGGAAGTACTGGACATTCTAACTCGCCTGCCAGAGAGTGTGGAAAGACTCACAGGCGTGAGCATCTCCCAGGTG
AATCACAAGCCTTTGAGAACAGCCTGAGCCTTCAGCCCTCACAGATGCCCAGCCTCATAGCTGAAGTTGCCTGAATGATCCTCCTGTTGC

>15646_15646_2_CELSR1-FLOT1_CELSR1_chr22_46804892_ENST00000262738_FLOT1_chr6_30698877_ENST00000456573_length(amino acids)=1928AA_BP=1741
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQV
RLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAH
YTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVE
DENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPF
QIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT
LSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTIL
DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR
PLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCR
CPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSV
QVQYYNKPNIGHLGLPHGPSGEKMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDFPVHNRQFVGC
MRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRWNMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIIS
VPWYLGLMFRTRKEDSVLMEATSGGPTSFRLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYKLERLAE
AEKSQLIMQAEAEAASVRMRGEAEAFAIGARARAEAEQMAKKAEAFQLYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CELSR1-FLOT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CELSR1-FLOT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CELSR1-FLOT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource