FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CELSR1-STK24 (FusionGDB2 ID:15660)

Fusion Gene Summary for CELSR1-STK24

check button Fusion gene summary
Fusion gene informationFusion gene name: CELSR1-STK24
Fusion gene ID: 15660
HgeneTgene
Gene symbol

CELSR1

STK24

Gene ID

9620

8428

Gene namecadherin EGF LAG seven-pass G-type receptor 1serine/threonine kinase 24
SynonymsADGRC1|CDHF9|FMI2|HFMI2|ME2HEL-S-95|MST3|MST3B|STE20|STK3
Cytomap

22q13.31

13q32.2

Type of geneprotein-codingprotein-coding
Descriptioncadherin EGF LAG seven-pass G-type receptor 1adhesion G protein-coupled receptor C1cadherin family member 9cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)flamingo homolog 2protocadherin flamingo 2serine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3
Modification date2020032220200313
UniProtAcc

Q9NYQ6

.
Ensembl transtripts involved in fusion geneENST00000262738, ENST00000395964, 
ENST00000497509, 		ENST00000376547, 
ENST00000481288, ENST00000397517, 
ENST00000539966, 
Fusion gene scores* DoF score23 X 19 X 11=480715 X 8 X 8=960
# samples 2818
** MAII scorelog2(28/4807*10)=-4.10163807119293
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/960*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CELSR1 [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCELSR1(46829289)-STK24(99127612), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTK24

GO:0006468

protein phosphorylation

19604147

TgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

TgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516


check buttonFusion gene breakpoints across CELSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STK24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1029CELSR1chr22

46829289

-STK24chr13

99127612

-


Top

Fusion Gene ORF analysis for CELSR1-STK24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262738ENST00000376547CELSR1chr22

46829289

-STK24chr13

99127612

-
5CDS-intronENST00000262738ENST00000481288CELSR1chr22

46829289

-STK24chr13

99127612

-
In-frameENST00000262738ENST00000397517CELSR1chr22

46829289

-STK24chr13

99127612

-
In-frameENST00000262738ENST00000539966CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-3CDSENST00000395964ENST00000397517CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-3CDSENST00000395964ENST00000539966CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-3CDSENST00000497509ENST00000397517CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-3CDSENST00000497509ENST00000539966CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-intronENST00000395964ENST00000376547CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-intronENST00000395964ENST00000481288CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-intronENST00000497509ENST00000376547CELSR1chr22

46829289

-STK24chr13

99127612

-
intron-intronENST00000497509ENST00000481288CELSR1chr22

46829289

-STK24chr13

99127612

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262738CELSR1chr2246829289-ENST00000397517STK24chr1399127612-85494611055761858
ENST00000262738CELSR1chr2246829289-ENST00000539966STK24chr1399127612-58354611055761858

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262738ENST00000397517CELSR1chr2246829289-STK24chr1399127612-0.0004597380.9995403
ENST00000262738ENST00000539966CELSR1chr2246829289-STK24chr1399127612-0.0015374770.99846256

Top

Fusion Genomic Features for CELSR1-STK24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CELSR1-STK24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:46829289/chr13:99127612)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CELSR1

Q9NYQ6

.
FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351000_110115373015.0DomainCadherin 8
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351106_122415373015.0DomainCadherin 9
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351303_136115373015.0DomainEGF-like 1%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351363_139915373015.0DomainEGF-like 2%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351403_144115373015.0DomainEGF-like 3%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535246_35315373015.0DomainCadherin 1
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535354_45915373015.0DomainCadherin 2
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535460_56515373015.0DomainCadherin 3
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535566_68715373015.0DomainCadherin 4
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535688_78915373015.0DomainCadherin 5
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535790_89215373015.0DomainCadherin 6
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-535893_99915373015.0DomainCadherin 7
TgeneSTK24chr22:46829289chr13:99127612ENST00000376547211278_292122444.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr22:46829289chr13:99127612ENST00000376547211335_386122444.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr22:46829289chr13:99127612ENST00000397517211278_292110432.0MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr22:46829289chr13:99127612ENST00000397517211335_386110432.0MotifNote=Nuclear export signal (NES)
TgeneSTK24chr22:46829289chr13:99127612ENST00000397517211112_114110432.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352659_266315373015.0Compositional biasNote=Poly-Leu
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351442_164615373015.0DomainLaminin G-like 1
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351649_168515373015.0DomainEGF-like 4%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351689_187015373015.0DomainLaminin G-like 2
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351872_190715373015.0DomainEGF-like 5%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351908_194615373015.0DomainEGF-like 6%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351947_197915373015.0DomainEGF-like 7%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5351981_201615373015.0DomainEGF-like 8%3B calcium-binding
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352003_205015373015.0DomainLaminin EGF-like
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352408_246015373015.0DomainGPS
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-53522_246915373015.0Topological domainExtracellular
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352491_250115373015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352523_252715373015.0Topological domainExtracellular
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352549_257215373015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352594_261115373015.0Topological domainExtracellular
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352633_265515373015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352677_268315373015.0Topological domainExtracellular
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352705_301415373015.0Topological domainCytoplasmic
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352470_249015373015.0TransmembraneHelical%3B Name%3D1
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352502_252215373015.0TransmembraneHelical%3B Name%3D2
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352528_254815373015.0TransmembraneHelical%3B Name%3D3
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352573_259315373015.0TransmembraneHelical%3B Name%3D4
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352612_263215373015.0TransmembraneHelical%3B Name%3D5
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352656_267615373015.0TransmembraneHelical%3B Name%3D6
HgeneCELSR1chr22:46829289chr13:99127612ENST00000262738-5352684_270415373015.0TransmembraneHelical%3B Name%3D7
TgeneSTK24chr22:46829289chr13:99127612ENST0000037654721136_286122444.0DomainProtein kinase
TgeneSTK24chr22:46829289chr13:99127612ENST0000039751721136_286110432.0DomainProtein kinase
TgeneSTK24chr22:46829289chr13:99127612ENST00000376547211112_114122444.0Nucleotide bindingNote=ATP
TgeneSTK24chr22:46829289chr13:99127612ENST0000037654721142_50122444.0Nucleotide bindingNote=ATP
TgeneSTK24chr22:46829289chr13:99127612ENST0000039751721142_50110432.0Nucleotide bindingNote=ATP


Top

Fusion Gene Sequence for CELSR1-STK24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15660_15660_1_CELSR1-STK24_CELSR1_chr22_46829289_ENST00000262738_STK24_chr13_99127612_ENST00000397517_length(transcript)=8549nt_BP=4611nt
ATGGCGCCGCCGCCGCCGCCCGTGCTGCCCGTGCTGCTGCTCCTGGCCGCCGCCGCCGCCCTGCCGGCGATGGGGCTGCGAGCGGCCGCC
TGGGAGCCGCGCGTACCCGGCGGGACCCGCGCCTTCGCCCTCCGGCCCGGCTGTACCTACGCGGTGGGCGCCGCTTGCACGCCCCGGGCG
CCGCGGGAGCTGCTGGACGTGGGCCGCGATGGGCGGCTGGCAGGACGTCGGCGCGTCTCGGGCGCGGGGCGCCCGCTGCCGCTGCAAGTC
CGCTTGGTGGCCCGCAGTGCCCCGACGGCGCTGAGCCGCCGCCTGCGGGCGCGCACGCACCTTCCCGGCTGCGGAGCCCGTGCCCGGCTC
TGCGGAACCGGTGCCCGGCTCTGCGGGGCGCTCTGCTTCCCCGTCCCCGGCGGCTGCGCGGCCGCGCAGCATTCGGCGCTCGCAGCTCCG
ACCACCTTACCCGCCTGCCGCTGCCCGCCGCGCCCCAGGCCCCGCTGTCCCGGCCGTCCCATCTGCCTGCCGCCGGGCGGCTCGGTCCGC
CTGCGTCTGCTGTGCGCCCTGCGGCGCGCGGCTGGCGCCGTCCGGGTGGGACTGGCGCTGGAGGCCGCCACCGCGGGGACGCCCTCCGCG
TCGCCATCCCCATCGCCGCCCCTGCCGCCGAACTTGCCCGAAGCCCGGGCGGGGCCGGCGCGACGGGCCCGGCGGGGCACGAGCGGCAGA
GGGAGCCTGAAGTTTCCGATGCCCAACTACCAGGTGGCGTTGTTTGAGAACGAACCGGCGGGCACCCTCATCCTCCAGCTGCACGCGCAC
TACACCATCGAGGGCGAGGAGGAGCGCGTGAGCTATTACATGGAGGGGCTGTTCGACGAGCGCTCCCGGGGCTACTTCCGAATCGACTCT
GCCACGGGCGCCGTGAGCACGGACAGCGTACTGGACCGCGAGACCAAGGAGACGCACGTCCTCAGGGTGAAAGCCGTGGACTACAGTACG
CCGCCGCGCTCGGCCACCACCTACATCACTGTCTTGGTCAAAGACACCAACGACCACAGCCCGGTCTTCGAGCAGTCGGAGTACCGCGAG
CGCGTGCGGGAGAACCTGGAGGTGGGCTACGAGGTGCTGACCATCCGCGCCAGCGACCGCGACTCGCCCATCAACGCCAACTTGCGTTAC
CGCGTGTTGGGGGGCGCGTGGGACGTCTTCCAGCTCAACGAGAGCTCTGGCGTGGTGAGCACACGGGCGGTGCTGGACCGGGAGGAGGCG
GCCGAGTACCAGCTCCTGGTGGAGGCCAACGACCAGGGGCGCAATCCGGGCCCGCTCAGTGCCACGGCCACCGTGTACATCGAGGTGGAG
GACGAGAACGACAACTACCCCCAGTTCAGCGAGCAGAACTACGTGGTCCAGGTGCCCGAGGACGTGGGGCTCAACACGGCTGTGCTGCGA
GTGCAGGCCACGGACCGGGACCAGGGCCAGAACGCGGCCATTCACTACAGCATCCTCAGCGGGAACGTGGCCGGCCAGTTCTACCTGCAC
TCGCTGAGCGGGATCCTGGATGTGATCAACCCCTTGGATTTCGAGGATGTCCAGAAATACTCGCTGAGCATTAAGGCCCAGGATGGGGGC
CGGCCCCCGCTCATCAATTCTTCAGGGGTGGTGTCTGTGCAGGTGCTGGATGTCAACGACAACGAGCCTATCTTTGTGAGCAGCCCCTTC
CAGGCCACGGTGCTGGAGAATGTGCCCCTGGGCTACCCCGTGGTGCACATTCAGGCGGTGGACGCGGACTCTGGAGAGAACGCCCGGCTG
CACTATCGCCTGGTGGACACGGCCTCCACCTTTCTGGGGGGCGGCAGCGCTGGGCCTAAGAATCCTGCCCCCACCCCTGACTTCCCCTTC
CAGATCCACAACAGCTCCGGTTGGATCACAGTGTGTGCCGAGCTGGACCGCGAGGAGGTGGAGCACTACAGCTTCGGGGTGGAGGCGGTG
GACCACGGCTCGCCCCCCATGAGCTCCTCCACCAGCGTGTCCATCACGGTGCTGGACGTGAATGACAACGACCCGGTGTTCACGCAGCCC
ACCTACGAGCTTCGTCTGAATGAGGATGCGGCCGTGGGGAGCAGCGTGCTGACCCTGCAGGCCCGCGACCGTGACGCCAACAGTGTGATT
ACCTACCAGCTCACAGGCGGCAACACCCGGAACCGCTTTGCACTCAGCAGCCAGAGAGGGGGCGGCCTCATCACCCTGGCGCTACCTCTG
GACTACAAGCAGGAGCAGCAGTACGTGCTGGCGGTGACAGCATCCGACGGCACACGGTCGCACACTGCGCATGTCCTAATCAACGTCACT
GATGCCAACACCCACAGGCCTGTCTTTCAGAGCTCCCATTACACAGTGAGTGTCAGTGAGGACAGGCCTGTGGGCACCTCCATTGCTACC
CTCAGTGCCAACGATGAGGACACAGGAGAGAATGCCCGCATCACCTACGTGATTCAGGACCCCGTGCCGCAGTTCCGCATTGACCCCGAC
AGTGGCACCATGTACACCATGATGGAGCTGGACTATGAGAACCAGGTCGCCTACACGCTGACCATCATGGCCCAGGACAACGGCATCCCG
CAGAAATCAGACACCACCACCCTAGAGATCCTCATCCTCGATGCCAATGACAATGCACCCCAGTTCCTGTGGGATTTCTACCAGGGTTCC
ATCTTTGAGGATGCTCCACCCTCGACCAGCATCCTCCAGGTCTCTGCCACGGACCGGGACTCAGGTCCCAATGGGCGTCTGCTGTACACC
TTCCAGGGTGGGGACGACGGCGATGGGGACTTCTACATCGAGCCCACGTCCGGTGTGATTCGCACCCAGCGCCGGCTGGACCGGGAGAAT
GTGGCCGTGTACAACCTTTGGGCTCTGGCTGTGGATCGGGGCAGTCCCACTCCCCTTAGCGCCTCGGTAGAAATCCAGGTGACCATCTTG
GACATTAATGACAATGCCCCCATGTTTGAGAAGGACGAACTGGAGCTGTTTGTTGAGGAGAACAACCCAGTGGGGTCGGTGGTGGCAAAG
ATTCGTGCTAACGACCCTGATGAAGGCCCTAATGCCCAGATCATGTATCAGATTGTGGAAGGGGACATGCGGCATTTCTTCCAGCTGGAC
CTGCTCAACGGGGACCTGCGTGCCATGGTGGAGCTGGACTTTGAGGTCCGGCGGGAGTATGTGCTGGTGGTGCAGGCCACGTCGGCTCCG
CTGGTGAGCCGAGCCACGGTGCACATCCTTCTCGTGGACCAGAATGACAACCCGCCTGTGCTGCCCGACTTCCAGATCCTCTTCAACAAC
TATGTCACCAACAAGTCCAACAGTTTCCCCACCGGCGTGATCGGCTGCATCCCGGCCCATGACCCCGACGTGTCAGACAGCCTCAACTAC
ACCTTCGTGCAGGGCAACGAGCTGCGCCTGTTGCTGCTGGACCCCGCCACGGGCGAACTGCAGCTCAGCCGCGACCTGGACAACAACCGG
CCGCTGGAGGCGCTCATGGAGGTGTCTGTGTCTGATGGCATCCACAGCGTCACGGCCTTCTGCACCCTGCGTGTCACCATCATCACGGAC
GACATGCTGACCAACAGCATCACTGTCCGCCTGGAGAACATGTCCCAGGAGAAGTTCCTGTCCCCGCTGCTGGCCCTCTTCGTGGAGGGG
GTGGCCGCCGTGCTGTCCACCACCAAGGACGACGTCTTCGTCTTCAACGTCCAGAACGACACCGACGTCAGCTCCAACATCCTGAACGTG
ACCTTCTCGGCGCTGCTGCCTGGCGGCGTCCGCGGCCAGTTCTTCCCGTCGGAGGACCTGCAGGAGCAGATCTACCTGAATCGGACGCTG
CTGACCACCATCTCCACGCAGCGCGTGCTGCCCTTCGACGACAACATCTGCCTGCGCGAGCCCTGCGAGAACTACATGAAGTGCGTGTCC
GTTCTGCGATTCGACAGCTCCGCGCCCTTCCTCAGCTCCACCACCGTGCTCTTCCGGCCCATCCACCCCATCAACGGCCTGCGCTGCCGC
TGCCCGCCCGGCTTCACCGGCGACTACTGCGAGACGGAGATCGACCTCTGCTACTCCGACCCGTGCGGCGCCAACGGCCGCTGCCGCAGC
CGCGAGGGCGGCTACACCTGCGAGTGCTTCGAGGACTTCACTGGAGAGCACTGTGAGGTGGATGCCCGCTCAGGCCGCTGTGCCAACGGG
GTGTGCAAGAACGGGGGCACCTGCGTGAACCTGCTCATCGGCGGCTTCCACTGCGTGTGTCCTCCTGGCGAGTATGAGAGGCCCTACTGT
GAGGTGACCACCAGGAGCTTCCCGCCCCAGTCCTTCGTCACCTTCCGGGGCCTGAGACAGCGCTTCCACTTCACCATCTCCCTCACGTTT
GCCACTCAGGAAAGGAACGGCTTGCTTCTCTACAACGGCCGCTTCAATGAGAAGCACGACTTCATCGCCCTGGAGATCGTGGACGAGCAG
GTGCAGCTCACCTTCTCTGCAGGCGAGACAACAACGACCGTGGCACCGAAGGTTCCCAGTGGTGTGAGTGACGGGCGGTGGCACTCTGTG
CAGGTGCAGTACTACAACAAGTTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGAT
TATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTT
GGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAG
TCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCAC
CCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCC
TGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTAC
TTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGAT
GGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAG
CCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCA
GAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGC
CCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAAT
TCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCAC
CGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTC
TCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTTTATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACAT
ATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATATTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGG
TATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTCTGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTAC
GGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCAAGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAG
GCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGAATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGG
GTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTTGTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCC
CTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTATTTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGC
TTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGACATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTA
CCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGCATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAA
ATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTCTTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGT
GTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCAGGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCA
GCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGAGGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACC
TTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAGGCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTT
GCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGTGCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTT
GTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGGAGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGA
GCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCTATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGG
GTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAATTGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAAT
TTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAATTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGA
ATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCTGTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGT
CAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTCCCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCG
GACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGACAATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTA
GTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGGTATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTC
AGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGGCAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGA
AAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGACGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCA
AGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGAGCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCA
ACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTGTCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGC
TCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAGACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTT
GAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGGTTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCT
TGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGCTCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGT
ACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATTTCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATG

>15660_15660_1_CELSR1-STK24_CELSR1_chr22_46829289_ENST00000262738_STK24_chr13_99127612_ENST00000397517_length(amino acids)=1858AA_BP=1537
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQV
RLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAH
YTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVE
DENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPF
QIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT
LSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTIL
DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR
PLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCR
CPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSV
QVQYYNKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ
SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSY
LTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFA

--------------------------------------------------------------
>15660_15660_2_CELSR1-STK24_CELSR1_chr22_46829289_ENST00000262738_STK24_chr13_99127612_ENST00000539966_length(transcript)=5835nt_BP=4611nt
ATGGCGCCGCCGCCGCCGCCCGTGCTGCCCGTGCTGCTGCTCCTGGCCGCCGCCGCCGCCCTGCCGGCGATGGGGCTGCGAGCGGCCGCC
TGGGAGCCGCGCGTACCCGGCGGGACCCGCGCCTTCGCCCTCCGGCCCGGCTGTACCTACGCGGTGGGCGCCGCTTGCACGCCCCGGGCG
CCGCGGGAGCTGCTGGACGTGGGCCGCGATGGGCGGCTGGCAGGACGTCGGCGCGTCTCGGGCGCGGGGCGCCCGCTGCCGCTGCAAGTC
CGCTTGGTGGCCCGCAGTGCCCCGACGGCGCTGAGCCGCCGCCTGCGGGCGCGCACGCACCTTCCCGGCTGCGGAGCCCGTGCCCGGCTC
TGCGGAACCGGTGCCCGGCTCTGCGGGGCGCTCTGCTTCCCCGTCCCCGGCGGCTGCGCGGCCGCGCAGCATTCGGCGCTCGCAGCTCCG
ACCACCTTACCCGCCTGCCGCTGCCCGCCGCGCCCCAGGCCCCGCTGTCCCGGCCGTCCCATCTGCCTGCCGCCGGGCGGCTCGGTCCGC
CTGCGTCTGCTGTGCGCCCTGCGGCGCGCGGCTGGCGCCGTCCGGGTGGGACTGGCGCTGGAGGCCGCCACCGCGGGGACGCCCTCCGCG
TCGCCATCCCCATCGCCGCCCCTGCCGCCGAACTTGCCCGAAGCCCGGGCGGGGCCGGCGCGACGGGCCCGGCGGGGCACGAGCGGCAGA
GGGAGCCTGAAGTTTCCGATGCCCAACTACCAGGTGGCGTTGTTTGAGAACGAACCGGCGGGCACCCTCATCCTCCAGCTGCACGCGCAC
TACACCATCGAGGGCGAGGAGGAGCGCGTGAGCTATTACATGGAGGGGCTGTTCGACGAGCGCTCCCGGGGCTACTTCCGAATCGACTCT
GCCACGGGCGCCGTGAGCACGGACAGCGTACTGGACCGCGAGACCAAGGAGACGCACGTCCTCAGGGTGAAAGCCGTGGACTACAGTACG
CCGCCGCGCTCGGCCACCACCTACATCACTGTCTTGGTCAAAGACACCAACGACCACAGCCCGGTCTTCGAGCAGTCGGAGTACCGCGAG
CGCGTGCGGGAGAACCTGGAGGTGGGCTACGAGGTGCTGACCATCCGCGCCAGCGACCGCGACTCGCCCATCAACGCCAACTTGCGTTAC
CGCGTGTTGGGGGGCGCGTGGGACGTCTTCCAGCTCAACGAGAGCTCTGGCGTGGTGAGCACACGGGCGGTGCTGGACCGGGAGGAGGCG
GCCGAGTACCAGCTCCTGGTGGAGGCCAACGACCAGGGGCGCAATCCGGGCCCGCTCAGTGCCACGGCCACCGTGTACATCGAGGTGGAG
GACGAGAACGACAACTACCCCCAGTTCAGCGAGCAGAACTACGTGGTCCAGGTGCCCGAGGACGTGGGGCTCAACACGGCTGTGCTGCGA
GTGCAGGCCACGGACCGGGACCAGGGCCAGAACGCGGCCATTCACTACAGCATCCTCAGCGGGAACGTGGCCGGCCAGTTCTACCTGCAC
TCGCTGAGCGGGATCCTGGATGTGATCAACCCCTTGGATTTCGAGGATGTCCAGAAATACTCGCTGAGCATTAAGGCCCAGGATGGGGGC
CGGCCCCCGCTCATCAATTCTTCAGGGGTGGTGTCTGTGCAGGTGCTGGATGTCAACGACAACGAGCCTATCTTTGTGAGCAGCCCCTTC
CAGGCCACGGTGCTGGAGAATGTGCCCCTGGGCTACCCCGTGGTGCACATTCAGGCGGTGGACGCGGACTCTGGAGAGAACGCCCGGCTG
CACTATCGCCTGGTGGACACGGCCTCCACCTTTCTGGGGGGCGGCAGCGCTGGGCCTAAGAATCCTGCCCCCACCCCTGACTTCCCCTTC
CAGATCCACAACAGCTCCGGTTGGATCACAGTGTGTGCCGAGCTGGACCGCGAGGAGGTGGAGCACTACAGCTTCGGGGTGGAGGCGGTG
GACCACGGCTCGCCCCCCATGAGCTCCTCCACCAGCGTGTCCATCACGGTGCTGGACGTGAATGACAACGACCCGGTGTTCACGCAGCCC
ACCTACGAGCTTCGTCTGAATGAGGATGCGGCCGTGGGGAGCAGCGTGCTGACCCTGCAGGCCCGCGACCGTGACGCCAACAGTGTGATT
ACCTACCAGCTCACAGGCGGCAACACCCGGAACCGCTTTGCACTCAGCAGCCAGAGAGGGGGCGGCCTCATCACCCTGGCGCTACCTCTG
GACTACAAGCAGGAGCAGCAGTACGTGCTGGCGGTGACAGCATCCGACGGCACACGGTCGCACACTGCGCATGTCCTAATCAACGTCACT
GATGCCAACACCCACAGGCCTGTCTTTCAGAGCTCCCATTACACAGTGAGTGTCAGTGAGGACAGGCCTGTGGGCACCTCCATTGCTACC
CTCAGTGCCAACGATGAGGACACAGGAGAGAATGCCCGCATCACCTACGTGATTCAGGACCCCGTGCCGCAGTTCCGCATTGACCCCGAC
AGTGGCACCATGTACACCATGATGGAGCTGGACTATGAGAACCAGGTCGCCTACACGCTGACCATCATGGCCCAGGACAACGGCATCCCG
CAGAAATCAGACACCACCACCCTAGAGATCCTCATCCTCGATGCCAATGACAATGCACCCCAGTTCCTGTGGGATTTCTACCAGGGTTCC
ATCTTTGAGGATGCTCCACCCTCGACCAGCATCCTCCAGGTCTCTGCCACGGACCGGGACTCAGGTCCCAATGGGCGTCTGCTGTACACC
TTCCAGGGTGGGGACGACGGCGATGGGGACTTCTACATCGAGCCCACGTCCGGTGTGATTCGCACCCAGCGCCGGCTGGACCGGGAGAAT
GTGGCCGTGTACAACCTTTGGGCTCTGGCTGTGGATCGGGGCAGTCCCACTCCCCTTAGCGCCTCGGTAGAAATCCAGGTGACCATCTTG
GACATTAATGACAATGCCCCCATGTTTGAGAAGGACGAACTGGAGCTGTTTGTTGAGGAGAACAACCCAGTGGGGTCGGTGGTGGCAAAG
ATTCGTGCTAACGACCCTGATGAAGGCCCTAATGCCCAGATCATGTATCAGATTGTGGAAGGGGACATGCGGCATTTCTTCCAGCTGGAC
CTGCTCAACGGGGACCTGCGTGCCATGGTGGAGCTGGACTTTGAGGTCCGGCGGGAGTATGTGCTGGTGGTGCAGGCCACGTCGGCTCCG
CTGGTGAGCCGAGCCACGGTGCACATCCTTCTCGTGGACCAGAATGACAACCCGCCTGTGCTGCCCGACTTCCAGATCCTCTTCAACAAC
TATGTCACCAACAAGTCCAACAGTTTCCCCACCGGCGTGATCGGCTGCATCCCGGCCCATGACCCCGACGTGTCAGACAGCCTCAACTAC
ACCTTCGTGCAGGGCAACGAGCTGCGCCTGTTGCTGCTGGACCCCGCCACGGGCGAACTGCAGCTCAGCCGCGACCTGGACAACAACCGG
CCGCTGGAGGCGCTCATGGAGGTGTCTGTGTCTGATGGCATCCACAGCGTCACGGCCTTCTGCACCCTGCGTGTCACCATCATCACGGAC
GACATGCTGACCAACAGCATCACTGTCCGCCTGGAGAACATGTCCCAGGAGAAGTTCCTGTCCCCGCTGCTGGCCCTCTTCGTGGAGGGG
GTGGCCGCCGTGCTGTCCACCACCAAGGACGACGTCTTCGTCTTCAACGTCCAGAACGACACCGACGTCAGCTCCAACATCCTGAACGTG
ACCTTCTCGGCGCTGCTGCCTGGCGGCGTCCGCGGCCAGTTCTTCCCGTCGGAGGACCTGCAGGAGCAGATCTACCTGAATCGGACGCTG
CTGACCACCATCTCCACGCAGCGCGTGCTGCCCTTCGACGACAACATCTGCCTGCGCGAGCCCTGCGAGAACTACATGAAGTGCGTGTCC
GTTCTGCGATTCGACAGCTCCGCGCCCTTCCTCAGCTCCACCACCGTGCTCTTCCGGCCCATCCACCCCATCAACGGCCTGCGCTGCCGC
TGCCCGCCCGGCTTCACCGGCGACTACTGCGAGACGGAGATCGACCTCTGCTACTCCGACCCGTGCGGCGCCAACGGCCGCTGCCGCAGC
CGCGAGGGCGGCTACACCTGCGAGTGCTTCGAGGACTTCACTGGAGAGCACTGTGAGGTGGATGCCCGCTCAGGCCGCTGTGCCAACGGG
GTGTGCAAGAACGGGGGCACCTGCGTGAACCTGCTCATCGGCGGCTTCCACTGCGTGTGTCCTCCTGGCGAGTATGAGAGGCCCTACTGT
GAGGTGACCACCAGGAGCTTCCCGCCCCAGTCCTTCGTCACCTTCCGGGGCCTGAGACAGCGCTTCCACTTCACCATCTCCCTCACGTTT
GCCACTCAGGAAAGGAACGGCTTGCTTCTCTACAACGGCCGCTTCAATGAGAAGCACGACTTCATCGCCCTGGAGATCGTGGACGAGCAG
GTGCAGCTCACCTTCTCTGCAGGCGAGACAACAACGACCGTGGCACCGAAGGTTCCCAGTGGTGTGAGTGACGGGCGGTGGCACTCTGTG
CAGGTGCAGTACTACAACAAGTTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGAT
TATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTT
GGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAG
TCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCAC
CCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCC
TGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTAC
TTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGAT
GGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAG
CCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCA
GAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGC
CCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAAT
TCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCAC
CGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTC

>15660_15660_2_CELSR1-STK24_CELSR1_chr22_46829289_ENST00000262738_STK24_chr13_99127612_ENST00000539966_length(amino acids)=1858AA_BP=1537
MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFALRPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQV
RLVARSAPTALSRRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPPRPRPRCPGRPICLPPGGSVR
LRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPLPPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAH
YTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE
RVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVE
DENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGG
RPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPF
QIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVI
TYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIAT
LSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGS
IFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTIL
DINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP
LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR
PLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNV
TFSALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVSVLRFDSSAPFLSSTTVLFRPIHPINGLRCR
CPPGFTGDYCETEIDLCYSDPCGANGRCRSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYERPYC
EVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIALEIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSV
QVQYYNKLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ
SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSY
LTELIDRYKRWKAEQSHDDSSSEDSDAETDGQASGGSDSGDWIFTIREKDPKNLENGALQPSDLDRNKMKDIPKRPFSQCLSTIISPLFA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CELSR1-STK24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CELSR1-STK24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CELSR1-STK24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource