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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CENPE-DDX60L (FusionGDB2 ID:15693)

Fusion Gene Summary for CENPE-DDX60L

check button Fusion gene summary
Fusion gene informationFusion gene name: CENPE-DDX60L
Fusion gene ID: 15693
HgeneTgene
Gene symbol

CENPE

DDX60L

Gene ID

1062

91351

Gene namecentromere protein EDExD/H-box 60 like
SynonymsCENP-E|KIF10|MCPH13|PPP1R61-
Cytomap

4q24

4q32.3

Type of geneprotein-codingprotein-coding
Descriptioncentromere-associated protein ECentromere autoantigen E (312kD)centromere protein E, 312kDakinesin family member 10kinesin-7kinesin-related protein CENPEprotein phosphatase 1, regulatory subunit 61probable ATP-dependent RNA helicase DDX60-likeDEAD (Asp-Glu-Ala-Asp) box polypeptide 60-likeDEAD box protein 60-likeDEAD-box helicase 60 likeputative ATP-dependent RNA helicase DDX60
Modification date2020031320200313
UniProtAcc.

Q5H9U9

Ensembl transtripts involved in fusion geneENST00000265148, ENST00000380026, 
ENST00000509120, 		ENST00000515088, 
ENST00000260184, ENST00000505890, 
ENST00000511577, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 4=64
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CENPE [Title/Abstract] AND DDX60L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCENPE(104115386)-DDX60L(169327857), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCENPE

GO:0007079

mitotic chromosome movement towards spindle pole

25908662

HgeneCENPE

GO:0051382

kinetochore assembly

9763420

HgeneCENPE

GO:0099606

microtubule plus-end directed mitotic chromosome migration

25908662


check buttonFusion gene breakpoints across CENPE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX60L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-EQ-8122-01ACENPEchr4

104115386

-DDX60Lchr4

169327857

-


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Fusion Gene ORF analysis for CENPE-DDX60L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265148ENST00000515088CENPEchr4

104115386

-DDX60Lchr4

169327857

-
5CDS-intronENST00000380026ENST00000515088CENPEchr4

104115386

-DDX60Lchr4

169327857

-
In-frameENST00000265148ENST00000260184CENPEchr4

104115386

-DDX60Lchr4

169327857

-
In-frameENST00000265148ENST00000505890CENPEchr4

104115386

-DDX60Lchr4

169327857

-
In-frameENST00000265148ENST00000511577CENPEchr4

104115386

-DDX60Lchr4

169327857

-
In-frameENST00000380026ENST00000260184CENPEchr4

104115386

-DDX60Lchr4

169327857

-
In-frameENST00000380026ENST00000505890CENPEchr4

104115386

-DDX60Lchr4

169327857

-
In-frameENST00000380026ENST00000511577CENPEchr4

104115386

-DDX60Lchr4

169327857

-
intron-3CDSENST00000509120ENST00000260184CENPEchr4

104115386

-DDX60Lchr4

169327857

-
intron-3CDSENST00000509120ENST00000505890CENPEchr4

104115386

-DDX60Lchr4

169327857

-
intron-3CDSENST00000509120ENST00000511577CENPEchr4

104115386

-DDX60Lchr4

169327857

-
intron-intronENST00000509120ENST00000515088CENPEchr4

104115386

-DDX60Lchr4

169327857

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265148CENPEchr4104115386-ENST00000260184DDX60Lchr4169327857-4337783302924964
ENST00000265148CENPEchr4104115386-ENST00000511577DDX60Lchr4169327857-4337783302924964
ENST00000265148CENPEchr4104115386-ENST00000505890DDX60Lchr4169327857-2151783301730566
ENST00000380026CENPEchr4104115386-ENST00000260184DDX60Lchr4169327857-4336782292923964
ENST00000380026CENPEchr4104115386-ENST00000511577DDX60Lchr4169327857-4336782292923964
ENST00000380026CENPEchr4104115386-ENST00000505890DDX60Lchr4169327857-2150782291729566

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265148ENST00000260184CENPEchr4104115386-DDX60Lchr4169327857-6.98E-050.99993026
ENST00000265148ENST00000511577CENPEchr4104115386-DDX60Lchr4169327857-6.98E-050.99993026
ENST00000265148ENST00000505890CENPEchr4104115386-DDX60Lchr4169327857-0.0002027420.9997973
ENST00000380026ENST00000260184CENPEchr4104115386-DDX60Lchr4169327857-7.00E-050.99993
ENST00000380026ENST00000511577CENPEchr4104115386-DDX60Lchr4169327857-7.00E-050.99993
ENST00000380026ENST00000505890CENPEchr4104115386-DDX60Lchr4169327857-0.0002044840.9997955

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Fusion Genomic Features for CENPE-DDX60L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CENPE-DDX60L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:104115386/chr4:169327857)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DDX60L

Q5H9U9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCENPEchr4:104115386chr4:169327857ENST00000265148-84986_932312702.0Nucleotide bindingNote=ATP
HgeneCENPEchr4:104115386chr4:169327857ENST00000380026-84786_932312581.0Nucleotide bindingNote=ATP
TgeneDDX60Lchr4:104115386chr4:169327857ENST0000026018421381205_13549931707.0DomainHelicase C-terminal
TgeneDDX60Lchr4:104115386chr4:169327857ENST0000050589021301205_13549931309.0DomainHelicase C-terminal
TgeneDDX60Lchr4:104115386chr4:169327857ENST0000051157721381205_13549931707.0DomainHelicase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCENPEchr4:104115386chr4:169327857ENST00000265148-849336_25902312702.0Coiled coilOntology_term=ECO:0000255
HgeneCENPEchr4:104115386chr4:169327857ENST00000380026-847336_25902312581.0Coiled coilOntology_term=ECO:0000255
HgeneCENPEchr4:104115386chr4:169327857ENST00000265148-8496_3292312702.0DomainKinesin motor
HgeneCENPEchr4:104115386chr4:169327857ENST00000380026-8476_3292312581.0DomainKinesin motor
HgeneCENPEchr4:104115386chr4:169327857ENST00000265148-8492126_24762312702.0RegionNote=Kinetochore-binding domain
HgeneCENPEchr4:104115386chr4:169327857ENST00000265148-8492510_26982312702.0RegionGlobular autoinhibitory domain
HgeneCENPEchr4:104115386chr4:169327857ENST00000380026-8472126_24762312581.0RegionNote=Kinetochore-binding domain
HgeneCENPEchr4:104115386chr4:169327857ENST00000380026-8472510_26982312581.0RegionGlobular autoinhibitory domain
TgeneDDX60Lchr4:104115386chr4:169327857ENST000002601842138752_9199931707.0DomainHelicase ATP-binding
TgeneDDX60Lchr4:104115386chr4:169327857ENST000005058902130752_9199931309.0DomainHelicase ATP-binding
TgeneDDX60Lchr4:104115386chr4:169327857ENST000005115772138752_9199931707.0DomainHelicase ATP-binding
TgeneDDX60Lchr4:104115386chr4:169327857ENST000002601842138869_8729931707.0MotifNote=DEAH box
TgeneDDX60Lchr4:104115386chr4:169327857ENST000005058902130869_8729931309.0MotifNote=DEAH box
TgeneDDX60Lchr4:104115386chr4:169327857ENST000005115772138869_8729931707.0MotifNote=DEAH box
TgeneDDX60Lchr4:104115386chr4:169327857ENST000002601842138765_7729931707.0Nucleotide bindingATP
TgeneDDX60Lchr4:104115386chr4:169327857ENST000005058902130765_7729931309.0Nucleotide bindingATP
TgeneDDX60Lchr4:104115386chr4:169327857ENST000005115772138765_7729931707.0Nucleotide bindingATP


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Fusion Gene Sequence for CENPE-DDX60L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15693_15693_1_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000265148_DDX60L_chr4_169327857_ENST00000260184_length(transcript)=4337nt_BP=783nt
TAAATTTAAAGGCGGGGCGGCCTGTGAGCCCTGAAGTGCCGGCCGCGGAGGGTCCTGGCCATTTTCCTGGGACCAGTTCAGCCTGATAGG
ATGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTGGAGAAACTGCCCAAGTTTAC
TGGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAA
AATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCA
GGAAAAACATATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTT
CCTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACAGATTTACTCTGTGGCACTCAAAAAATGAAA
CCTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAA
TGGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATT
TTGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGATTGAAAAGTATGGATTCCCACCTGAT
CTTACCCTCACCCCTCAAGAAAGCATCCAGCTTTATGATACCATGGCTCAAGTCTGGGAAACTTGGCCCAGGGCTCAGGAATTGTGTCCA
GAGGAATTCATTCTTTTTAAGAATAAGATAGTCATTAAGAAGTTGGATGCTAGAAAATATGAAGAAAACTTAAAGGCAGAATTGACAAAT
TGGATTAAAAATGGCCAAGTGAAGAAGGTCAAAAGAGTACTGAAGAACCTTAGTCCGGATTCATTGTCTAGTTCAAAAGATATGGTGAAA
ATGTTTCCTCTTCTTGTTGAAAAGTTAAGACAAATGGATAAGTTGCCTGCAATATTTTTTTTGTTTAAGAATGATGATGTGGGAAAAAGA
GCTGGAAGTGTGTGCACTTTTCTGGAGAAGACAGAGACAAAAAGCCATCCCCACACTGAATGTCATAGTTATGTCTTTGCAATAGATGAA
GTACTTGAAAAAGTGAGGAAGACACAGAAAAGGATCACTAAAAAAAACCCAAAGAAGGCTGAAAAACTGGAAAGAAAAAAAGTGTATAGA
GCTGAATATATTAATTTCCTGGAGAATCTGAAGATTCTGGAAATTTCTGAGGACTGCACGTATGCTGATGTCAAAGCCCTACACACTGAA
ATTACCAGGAATAAAGACTCAACTTTGGAGAGGGTATTACCGCGAGTGCGATTTACAAGACACGGCAAAGAACTGAAGGCTTTAGCACAA
AGGGGGATTGGATATCATCACAGCAGCATGTATTTTAAAGAAAAAGAGTTTGTTGAGATACTCTTTGTAAAAGGGCTTATTAGGGTAGTG
ACAGCTACTGAAACACTTGCCTTAGGGATCCACATGCCATGCAAATCTGTTGTTTTTGCCCAAGACTCAGTCTATCTGGATGCTTTAAAT
TACAGACAGATGTCTGGTCGTGCTGGAAGAAGAGGTCAAGACCTGCTTGGAAATGTGTATTTCTTTGATATCCCATTGCCCAAAATAAAA
AGACTCCTTGCATCCAGTGTTCCTGAGCTGAGAGGACAGTTCCCTCTCAGCATAACCCTGGTCCTGCGACTCATGCTGCTGGCTTCCAAG
GGAGATGACCCAGAGGATGCCAAGGCAAAGGTGTTGTCAGTGCTAAAGCATTCATTGCTGTCTTTTAAGAGACGAAGAGCCATGGAGACT
TTGAAACTTTACTTTTTGTTTTCCTTGCAGCTCCTTATCAAAGAGGACTATTTAAATAAAAAGGGTAATCCAAAGAAATTTGCAGGACTT
GCATCATATTTGCATGGTCATGAACCTTCAAATCTTGTTTTTGTAAATTTTCTCAAGAGAGGCCTTTTCCATAATCTCTGTAAGCCAGCC
TGGAAAGGCTCACAACAATTTTCCCAAGATGTGATGGAAAAGCTCGTGTTAGTATTGGCAAATTTGTTTGGAAGAAAATATATTCCAGCA
AAATTCCAAAATGCTAATTTAAGTTTTTCTCAGTCAAAGGTGATCCTTGCCGAACTCCCGGAGGATTTTAAAGCTGCTTTATATGAGTAT
AACCTGGCAGTAATGAAGGATTTTGCCTCCTTCCTGCTGATTGCTTCCAAGTCGGTGAACATGAAAAAAGAGCATCAACTCCCTTTGTCA
AGAATCAAATTCACAGGTAAAGAATGTGAAGACTCCCAACTCGTGTCTCACTTGATGAGCTGCAAGAAAGGAAGAGTAGCCATTTCACCA
TTTGTTTGTCTTTCGGGGAACACAGATAATGATTTGCTTCGACCAGAGACTATCAACCAGGTCATCCTGCGCACAGTCGGTGTTAGTGGC
ACTCAGGCTCCTCTGCTGTGGCCATGGAAATTAGATAACCGAGGAAGGAGAATGCCACTAAATGCATATGTGCTCAATTTCTATAAACAC
AACTGCTTGACAAGATTAGACCAAAAAAATGGGATGCGTATGGGACAGCTTTTAAAGTGTTTGAAAGATTTTGCATTCAACATTCAGGCT
ATCAGTGACTCCTTGAGTGAACTATGTGAAAATAAGCGTGACAATGTAGTCCTGGCATTTAAACAATTGAGTCAAACCTTTTATGAGAAA
CTTCAAGAAATGCAAATTCAAATGAGTCAAAATCATTTAGAATAACACCATGGAAAACTTTCAAGTCTGATTATGTGGTATTTATCCCTT
TGCAAGGAGAGATATAATTAAGCTTACACAATGAAATGGAAAAAATGTTTGTCTTGGAGTCAAACAGAATTAAACTCAGATATCAGCTCT
GCTATTTTCTAACTGAATGACTTTAAGTTATGTAATATATCTGAGCTTTAACTTCATTTTTGGCAAAACCGGAGTAAAAATGAATACCTC
TAGTTGTTTTGAGGATTAAATGAGATAATGTAAGAAAAGTGATTGGGATTGGGTGGTGACTTAATGAACGGTAGTGGTTTTTTTAGTAGT
TAATGTATAGCAAAATTAGTTTCACATTGTCAAGTTTTCAATACATCCCCAAGTTAATTGAATTTTAAATTAATGATCAATAAATCACAA
AGGACCCAAATCAATTCTGAACAACAATTTAGTTATGTAAGAAGACTTCTGAGATTACAAGAAACTCACTGCTGTGGACTGGATGTTTGT
GCCCTCCCCTCCAAAATTTTTATATTGAAATTCTAACCCTCAATGTGATGGTATTAGGAGATGATAGGTCATGAGGGTGGAGCTCCTTGG
ATGTAATTAGTGCCTTTAACAGAGAGACAAGAGAGCTTGTTCTCCAATCTCTGCTCACTACCACTGGATGATACAATGGGAAGATGGCCA
TCTGCAGACCAAGAAGCAAGCCCTCAACAGAACTGAATCTACTTACACCATGATCTTGAACTTTCCAGCCTCCAGGATTGTGAGAAATAC
ATGTTTGTTGTTTAGCCATCTAGTCTGTGGTTTTCTGTTGAAGCAGTCTGAATTGACTAAAACAGTCACTTGGAGTAGTTATAAACCACT
TTCCTGTTGAAAGCAGAACATGCTGATTCAACTGTTTTGTTCAATAGCAATGATAGATTTTGTTTAAGTCCCCTACACTTTCTTATTTCT
AAATGATCAAGAGTACACTTCCTGGCAGTGATTAAGGAGTGTGTATCTAACAGAAAAAATATATATACCCTGTGAACCCGAATATGGAAT
TCAGATTGTTTCTGCCCTCAGTATCATACTTAAAAAACAAGCATACAAACAAACATAAGGGAACAAACAGCAACCATAACAAAAACAAAC
CTTTAAAGGTGCGTTTTTGCTGTGATAAATGAATACGGTACTCTGAAGGAGAAAAAAGTTTCTCAAATGAGCTTAAACTGCAAGTGATTT
AAAAATTAGAGAATATAATTCTTAAAGCTATTGAAAGTTTCAACCAGAAAACCTCAAGTGAATTTTGTATGTAAATGAAATCTTGAATGT
AAGTTCTGTGATTCTTTAAGCAAACAATTAGCTGAAAACTTGGTATTGTTGTAGTTTATGTAGTAAGTGACTTGGCACCCATCAGAAAAT

>15693_15693_1_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000265148_DDX60L_chr4_169327857_ENST00000260184_length(amino acids)=964AA_BP=251
MKCRPRRVLAIFLGPVQPDRMAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI
IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLIEKYGFPPDLTLTPQESIQ
LYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLR
QMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLENL
KILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGI
HMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPKIKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAK
VLSVLKHSLLSFKRRRAMETLKLYFLFSLQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQD
VMEKLVLVLANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLPLSRIKFTGKECE
DSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWPWKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKN

--------------------------------------------------------------
>15693_15693_2_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000265148_DDX60L_chr4_169327857_ENST00000505890_length(transcript)=2151nt_BP=783nt
TAAATTTAAAGGCGGGGCGGCCTGTGAGCCCTGAAGTGCCGGCCGCGGAGGGTCCTGGCCATTTTCCTGGGACCAGTTCAGCCTGATAGG
ATGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTGGAGAAACTGCCCAAGTTTAC
TGGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAA
AATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCA
GGAAAAACATATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTT
CCTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACAGATTTACTCTGTGGCACTCAAAAAATGAAA
CCTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAA
TGGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATT
TTGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGATTGAAAAGTATGGATTCCCACCTGAT
CTTACCCTCACCCCTCAAGAAAGCATCCAGCTTTATGATACCATGGCTCAAGTCTGGGAAACTTGGCCCAGGGCTCAGGAATTGTGTCCA
GAGGAATTCATTCTTTTTAAGAATAAGATAGTCATTAAGAAGTTGGATGCTAGAAAATATGAAGAAAACTTAAAGGCAGAATTGACAAAT
TGGATTAAAAATGGCCAAGTGAAGAAGGTCAAAAGAGTACTGAAGAACCTTAGTCCGGATTCATTGTCTAGTTCAAAAGATATGGTGAAA
ATGTTTCCTCTTCTTGTTGAAAAGTTAAGACAAATGGATAAGTTGCCTGCAATATTTTTTTTGTTTAAGAATGATGATGTGGGAAAAAGA
GCTGGAAGTGTGTGCACTTTTCTGGAGAAGACAGAGACAAAAAGCCATCCCCACACTGAATGTCATAGTTATGTCTTTGCAATAGATGAA
GTACTTGAAAAAGTGAGGAAGACACAGAAAAGGATTAGCACTAAAAAAAACCCAAAGAAGGCTGAAAAACTGGAAAGAAAAAAAGTGTAT
AGAGCTGAATATATTAATTTCCTGGAGAATCTGAAGATTCTGGAAATTTCTGAGGACTGCACGTATGCTGATGTCAAAGCCCTACACACT
GAAATTACCAGGAATAAAGACTCAACTTTGGAGAGGGTATTACCGCGAGTGCGATTTACAAGACACGGCAAAGAACTGAAGGCTTTAGCA
CAAAGGGGGATTGGATATCATCACAGCAGCATGTATTTTAAAGAAAAAGAGTTTGTTGAGATACTCTTTGTAAAAGGGCTTATTAGGGTA
GTGACAGCTACTGAAACACTTGCCTTAGGGATCCACATGCCATGCAAATCTGTTGTTTTTGCCCAAGACTCAGTCTATCTGGATGCTTTA
AATTACAGACAGATCATGTGAACTCTCCTAGACTGGAATATGAAGACTGTGATTTTACAGAGAAAAGGAGTTTATCTCCATTTCATGACC
TTTTAGGATGTTGCTGTTTCAACTTTAAAAGCCATATTTTCCTTTTCTCAAGTATAGCTATAGACCATATCACCTTTTACCATGTTCTGT
TATGAAAAACAGGAAGTCCCTGAGCTGGAATTTTTCAGTCTTTCTCTTTTTCATGTAGAGAGCAAAGTTTCTCTTAAGGGACTTTTGTTT
CCTTCAGAATTATGGTCTCCTTTTTTCTCTTCCTTGCCAAAATCACTAGTTTGGAAGAAATCCAACATCATTTATTTACTATGGACCACA

>15693_15693_2_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000265148_DDX60L_chr4_169327857_ENST00000505890_length(amino acids)=566AA_BP=251
MKCRPRRVLAIFLGPVQPDRMAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI
IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLIEKYGFPPDLTLTPQESIQ
LYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLR
QMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRISTKKNPKKAEKLERKKVYRAEYINFLEN
LKILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALG

--------------------------------------------------------------
>15693_15693_3_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000265148_DDX60L_chr4_169327857_ENST00000511577_length(transcript)=4337nt_BP=783nt
TAAATTTAAAGGCGGGGCGGCCTGTGAGCCCTGAAGTGCCGGCCGCGGAGGGTCCTGGCCATTTTCCTGGGACCAGTTCAGCCTGATAGG
ATGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTGGAGAAACTGCCCAAGTTTAC
TGGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAA
AATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCA
GGAAAAACATATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTT
CCTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACAGATTTACTCTGTGGCACTCAAAAAATGAAA
CCTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAA
TGGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATT
TTGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGATTGAAAAGTATGGATTCCCACCTGAT
CTTACCCTCACCCCTCAAGAAAGCATCCAGCTTTATGATACCATGGCTCAAGTCTGGGAAACTTGGCCCAGGGCTCAGGAATTGTGTCCA
GAGGAATTCATTCTTTTTAAGAATAAGATAGTCATTAAGAAGTTGGATGCTAGAAAATATGAAGAAAACTTAAAGGCAGAATTGACAAAT
TGGATTAAAAATGGCCAAGTGAAGAAGGTCAAAAGAGTACTGAAGAACCTTAGTCCGGATTCATTGTCTAGTTCAAAAGATATGGTGAAA
ATGTTTCCTCTTCTTGTTGAAAAGTTAAGACAAATGGATAAGTTGCCTGCAATATTTTTTTTGTTTAAGAATGATGATGTGGGAAAAAGA
GCTGGAAGTGTGTGCACTTTTCTGGAGAAGACAGAGACAAAAAGCCATCCCCACACTGAATGTCATAGTTATGTCTTTGCAATAGATGAA
GTACTTGAAAAAGTGAGGAAGACACAGAAAAGGATCACTAAAAAAAACCCAAAGAAGGCTGAAAAACTGGAAAGAAAAAAAGTGTATAGA
GCTGAATATATTAATTTCCTGGAGAATCTGAAGATTCTGGAAATTTCTGAGGACTGCACGTATGCTGATGTCAAAGCCCTACACACTGAA
ATTACCAGGAATAAAGACTCAACTTTGGAGAGGGTATTACCGCGAGTGCGATTTACAAGACACGGCAAAGAACTGAAGGCTTTAGCACAA
AGGGGGATTGGATATCATCACAGCAGCATGTATTTTAAAGAAAAAGAGTTTGTTGAGATACTCTTTGTAAAAGGGCTTATTAGGGTAGTG
ACAGCTACTGAAACACTTGCCTTAGGGATCCACATGCCATGCAAATCTGTTGTTTTTGCCCAAGACTCAGTCTATCTGGATGCTTTAAAT
TACAGACAGATGTCTGGTCGTGCTGGAAGAAGAGGTCAAGACCTGCTTGGAAATGTGTATTTCTTTGATATCCCATTGCCCAAAATAAAA
AGACTCCTTGCATCCAGTGTTCCTGAGCTGAGAGGACAGTTCCCTCTCAGCATAACCCTGGTCCTGCGACTCATGCTGCTGGCTTCCAAG
GGAGATGACCCAGAGGATGCCAAGGCAAAGGTGTTGTCAGTGCTAAAGCATTCATTGCTGTCTTTTAAGAGACGAAGAGCCATGGAGACT
TTGAAACTTTACTTTTTGTTTTCCTTGCAGCTCCTTATCAAAGAGGACTATTTAAATAAAAAGGGTAATCCAAAGAAATTTGCAGGACTT
GCATCATATTTGCATGGTCATGAACCTTCAAATCTTGTTTTTGTAAATTTTCTCAAGAGAGGCCTTTTCCATAATCTCTGTAAGCCAGCC
TGGAAAGGCTCACAACAATTTTCCCAAGATGTGATGGAAAAGCTCGTGTTAGTATTGGCAAATTTGTTTGGAAGAAAATATATTCCAGCA
AAATTCCAAAATGCTAATTTAAGTTTTTCTCAGTCAAAGGTGATCCTTGCCGAACTCCCGGAGGATTTTAAAGCTGCTTTATATGAGTAT
AACCTGGCAGTAATGAAGGATTTTGCCTCCTTCCTGCTGATTGCTTCCAAGTCGGTGAACATGAAAAAAGAGCATCAACTCCCTTTGTCA
AGAATCAAATTCACAGGTAAAGAATGTGAAGACTCCCAACTCGTGTCTCACTTGATGAGCTGCAAGAAAGGAAGAGTAGCCATTTCACCA
TTTGTTTGTCTTTCGGGGAACACAGATAATGATTTGCTTCGACCAGAGACTATCAACCAGGTCATCCTGCGCACAGTCGGTGTTAGTGGC
ACTCAGGCTCCTCTGCTGTGGCCATGGAAATTAGATAACCGAGGAAGGAGAATGCCACTAAATGCATATGTGCTCAATTTCTATAAACAC
AACTGCTTGACAAGATTAGACCAAAAAAATGGGATGCGTATGGGACAGCTTTTAAAGTGTTTGAAAGATTTTGCATTCAACATTCAGGCT
ATCAGTGACTCCTTGAGTGAACTATGTGAAAATAAGCGTGACAATGTAGTCCTGGCATTTAAACAATTGAGTCAAACCTTTTATGAGAAA
CTTCAAGAAATGCAAATTCAAATGAGTCAAAATCATTTAGAATAACACCATGGAAAACTTTCAAGTCTGATTATGTGGTATTTATCCCTT
TGCAAGGAGAGATATAATTAAGCTTACACAATGAAATGGAAAAAATGTTTGTCTTGGAGTCAAACAGAATTAAACTCAGATATCAGCTCT
GCTATTTTCTAACTGAATGACTTTAAGTTATGTAATATATCTGAGCTTTAACTTCATTTTTGGCAAAACCGGAGTAAAAATGAATACCTC
TAGTTGTTTTGAGGATTAAATGAGATAATGTAAGAAAAGTGATTGGGATTGGGTGGTGACTTAATGAACGGTAGTGGTTTTTTTAGTAGT
TAATGTATAGCAAAATTAGTTTCACATTGTCAAGTTTTCAATACATCCCCAAGTTAATTGAATTTTAAATTAATGATCAATAAATCACAA
AGGACCCAAATCAATTCTGAACAACAATTTAGTTATGTAAGAAGACTTCTGAGATTACAAGAAACTCACTGCTGTGGACTGGATGTTTGT
GCCCTCCCCTCCAAAATTTTTATATTGAAATTCTAACCCTCAATGTGATGGTATTAGGAGATGATAGGTCATGAGGGTGGAGCTCCTTGG
ATGTAATTAGTGCCTTTAACAGAGAGACAAGAGAGCTTGTTCTCCAATCTCTGCTCACTACCACTGGATGATACAATGGGAAGATGGCCA
TCTGCAGACCAAGAAGCAAGCCCTCAACAGAACTGAATCTACTTACACCATGATCTTGAACTTTCCAGCCTCCAGGATTGTGAGAAATAC
ATGTTTGTTGTTTAGCCATCTAGTCTGTGGTTTTCTGTTGAAGCAGTCTGAATTGACTAAAACAGTCACTTGGAGTAGTTATAAACCACT
TTCCTGTTGAAAGCAGAACATGCTGATTCAACTGTTTTGTTCAATAGCAATGATAGATTTTGTTTAAGTCCCCTACACTTTCTTATTTCT
AAATGATCAAGAGTACACTTCCTGGCAGTGATTAAGGAGTGTGTATCTAACAGAAAAAATATATATACCCTGTGAACCCGAATATGGAAT
TCAGATTGTTTCTGCCCTCAGTATCATACTTAAAAAACAAGCATACAAACAAACATAAGGGAACAAACAGCAACCATAACAAAAACAAAC
CTTTAAAGGTGCGTTTTTGCTGTGATAAATGAATACGGTACTCTGAAGGAGAAAAAAGTTTCTCAAATGAGCTTAAACTGCAAGTGATTT
AAAAATTAGAGAATATAATTCTTAAAGCTATTGAAAGTTTCAACCAGAAAACCTCAAGTGAATTTTGTATGTAAATGAAATCTTGAATGT
AAGTTCTGTGATTCTTTAAGCAAACAATTAGCTGAAAACTTGGTATTGTTGTAGTTTATGTAGTAAGTGACTTGGCACCCATCAGAAAAT

>15693_15693_3_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000265148_DDX60L_chr4_169327857_ENST00000511577_length(amino acids)=964AA_BP=251
MKCRPRRVLAIFLGPVQPDRMAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI
IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLIEKYGFPPDLTLTPQESIQ
LYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLR
QMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLENL
KILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGI
HMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPKIKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAK
VLSVLKHSLLSFKRRRAMETLKLYFLFSLQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQD
VMEKLVLVLANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLPLSRIKFTGKECE
DSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWPWKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKN

--------------------------------------------------------------
>15693_15693_4_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000380026_DDX60L_chr4_169327857_ENST00000260184_length(transcript)=4336nt_BP=782nt
AAATTTAAAGGCGGGGCGGCCTGTGAGCCCTGAAGTGCCGGCCGCGGAGGGTCCTGGCCATTTTCCTGGGACCAGTTCAGCCTGATAGGA
TGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTGGAGAAACTGCCCAAGTTTACT
GGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAAA
ATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCAG
GAAAAACATATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTTC
CTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACAGATTTACTCTGTGGCACTCAAAAAATGAAAC
CTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAAT
GGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATTT
TGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGATTGAAAAGTATGGATTCCCACCTGATC
TTACCCTCACCCCTCAAGAAAGCATCCAGCTTTATGATACCATGGCTCAAGTCTGGGAAACTTGGCCCAGGGCTCAGGAATTGTGTCCAG
AGGAATTCATTCTTTTTAAGAATAAGATAGTCATTAAGAAGTTGGATGCTAGAAAATATGAAGAAAACTTAAAGGCAGAATTGACAAATT
GGATTAAAAATGGCCAAGTGAAGAAGGTCAAAAGAGTACTGAAGAACCTTAGTCCGGATTCATTGTCTAGTTCAAAAGATATGGTGAAAA
TGTTTCCTCTTCTTGTTGAAAAGTTAAGACAAATGGATAAGTTGCCTGCAATATTTTTTTTGTTTAAGAATGATGATGTGGGAAAAAGAG
CTGGAAGTGTGTGCACTTTTCTGGAGAAGACAGAGACAAAAAGCCATCCCCACACTGAATGTCATAGTTATGTCTTTGCAATAGATGAAG
TACTTGAAAAAGTGAGGAAGACACAGAAAAGGATCACTAAAAAAAACCCAAAGAAGGCTGAAAAACTGGAAAGAAAAAAAGTGTATAGAG
CTGAATATATTAATTTCCTGGAGAATCTGAAGATTCTGGAAATTTCTGAGGACTGCACGTATGCTGATGTCAAAGCCCTACACACTGAAA
TTACCAGGAATAAAGACTCAACTTTGGAGAGGGTATTACCGCGAGTGCGATTTACAAGACACGGCAAAGAACTGAAGGCTTTAGCACAAA
GGGGGATTGGATATCATCACAGCAGCATGTATTTTAAAGAAAAAGAGTTTGTTGAGATACTCTTTGTAAAAGGGCTTATTAGGGTAGTGA
CAGCTACTGAAACACTTGCCTTAGGGATCCACATGCCATGCAAATCTGTTGTTTTTGCCCAAGACTCAGTCTATCTGGATGCTTTAAATT
ACAGACAGATGTCTGGTCGTGCTGGAAGAAGAGGTCAAGACCTGCTTGGAAATGTGTATTTCTTTGATATCCCATTGCCCAAAATAAAAA
GACTCCTTGCATCCAGTGTTCCTGAGCTGAGAGGACAGTTCCCTCTCAGCATAACCCTGGTCCTGCGACTCATGCTGCTGGCTTCCAAGG
GAGATGACCCAGAGGATGCCAAGGCAAAGGTGTTGTCAGTGCTAAAGCATTCATTGCTGTCTTTTAAGAGACGAAGAGCCATGGAGACTT
TGAAACTTTACTTTTTGTTTTCCTTGCAGCTCCTTATCAAAGAGGACTATTTAAATAAAAAGGGTAATCCAAAGAAATTTGCAGGACTTG
CATCATATTTGCATGGTCATGAACCTTCAAATCTTGTTTTTGTAAATTTTCTCAAGAGAGGCCTTTTCCATAATCTCTGTAAGCCAGCCT
GGAAAGGCTCACAACAATTTTCCCAAGATGTGATGGAAAAGCTCGTGTTAGTATTGGCAAATTTGTTTGGAAGAAAATATATTCCAGCAA
AATTCCAAAATGCTAATTTAAGTTTTTCTCAGTCAAAGGTGATCCTTGCCGAACTCCCGGAGGATTTTAAAGCTGCTTTATATGAGTATA
ACCTGGCAGTAATGAAGGATTTTGCCTCCTTCCTGCTGATTGCTTCCAAGTCGGTGAACATGAAAAAAGAGCATCAACTCCCTTTGTCAA
GAATCAAATTCACAGGTAAAGAATGTGAAGACTCCCAACTCGTGTCTCACTTGATGAGCTGCAAGAAAGGAAGAGTAGCCATTTCACCAT
TTGTTTGTCTTTCGGGGAACACAGATAATGATTTGCTTCGACCAGAGACTATCAACCAGGTCATCCTGCGCACAGTCGGTGTTAGTGGCA
CTCAGGCTCCTCTGCTGTGGCCATGGAAATTAGATAACCGAGGAAGGAGAATGCCACTAAATGCATATGTGCTCAATTTCTATAAACACA
ACTGCTTGACAAGATTAGACCAAAAAAATGGGATGCGTATGGGACAGCTTTTAAAGTGTTTGAAAGATTTTGCATTCAACATTCAGGCTA
TCAGTGACTCCTTGAGTGAACTATGTGAAAATAAGCGTGACAATGTAGTCCTGGCATTTAAACAATTGAGTCAAACCTTTTATGAGAAAC
TTCAAGAAATGCAAATTCAAATGAGTCAAAATCATTTAGAATAACACCATGGAAAACTTTCAAGTCTGATTATGTGGTATTTATCCCTTT
GCAAGGAGAGATATAATTAAGCTTACACAATGAAATGGAAAAAATGTTTGTCTTGGAGTCAAACAGAATTAAACTCAGATATCAGCTCTG
CTATTTTCTAACTGAATGACTTTAAGTTATGTAATATATCTGAGCTTTAACTTCATTTTTGGCAAAACCGGAGTAAAAATGAATACCTCT
AGTTGTTTTGAGGATTAAATGAGATAATGTAAGAAAAGTGATTGGGATTGGGTGGTGACTTAATGAACGGTAGTGGTTTTTTTAGTAGTT
AATGTATAGCAAAATTAGTTTCACATTGTCAAGTTTTCAATACATCCCCAAGTTAATTGAATTTTAAATTAATGATCAATAAATCACAAA
GGACCCAAATCAATTCTGAACAACAATTTAGTTATGTAAGAAGACTTCTGAGATTACAAGAAACTCACTGCTGTGGACTGGATGTTTGTG
CCCTCCCCTCCAAAATTTTTATATTGAAATTCTAACCCTCAATGTGATGGTATTAGGAGATGATAGGTCATGAGGGTGGAGCTCCTTGGA
TGTAATTAGTGCCTTTAACAGAGAGACAAGAGAGCTTGTTCTCCAATCTCTGCTCACTACCACTGGATGATACAATGGGAAGATGGCCAT
CTGCAGACCAAGAAGCAAGCCCTCAACAGAACTGAATCTACTTACACCATGATCTTGAACTTTCCAGCCTCCAGGATTGTGAGAAATACA
TGTTTGTTGTTTAGCCATCTAGTCTGTGGTTTTCTGTTGAAGCAGTCTGAATTGACTAAAACAGTCACTTGGAGTAGTTATAAACCACTT
TCCTGTTGAAAGCAGAACATGCTGATTCAACTGTTTTGTTCAATAGCAATGATAGATTTTGTTTAAGTCCCCTACACTTTCTTATTTCTA
AATGATCAAGAGTACACTTCCTGGCAGTGATTAAGGAGTGTGTATCTAACAGAAAAAATATATATACCCTGTGAACCCGAATATGGAATT
CAGATTGTTTCTGCCCTCAGTATCATACTTAAAAAACAAGCATACAAACAAACATAAGGGAACAAACAGCAACCATAACAAAAACAAACC
TTTAAAGGTGCGTTTTTGCTGTGATAAATGAATACGGTACTCTGAAGGAGAAAAAAGTTTCTCAAATGAGCTTAAACTGCAAGTGATTTA
AAAATTAGAGAATATAATTCTTAAAGCTATTGAAAGTTTCAACCAGAAAACCTCAAGTGAATTTTGTATGTAAATGAAATCTTGAATGTA
AGTTCTGTGATTCTTTAAGCAAACAATTAGCTGAAAACTTGGTATTGTTGTAGTTTATGTAGTAAGTGACTTGGCACCCATCAGAAAATA

>15693_15693_4_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000380026_DDX60L_chr4_169327857_ENST00000260184_length(amino acids)=964AA_BP=251
MKCRPRRVLAIFLGPVQPDRMAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI
IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLIEKYGFPPDLTLTPQESIQ
LYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLR
QMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLENL
KILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGI
HMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPKIKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAK
VLSVLKHSLLSFKRRRAMETLKLYFLFSLQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQD
VMEKLVLVLANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLPLSRIKFTGKECE
DSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWPWKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKN

--------------------------------------------------------------
>15693_15693_5_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000380026_DDX60L_chr4_169327857_ENST00000505890_length(transcript)=2150nt_BP=782nt
AAATTTAAAGGCGGGGCGGCCTGTGAGCCCTGAAGTGCCGGCCGCGGAGGGTCCTGGCCATTTTCCTGGGACCAGTTCAGCCTGATAGGA
TGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTGGAGAAACTGCCCAAGTTTACT
GGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAAA
ATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCAG
GAAAAACATATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTTC
CTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACAGATTTACTCTGTGGCACTCAAAAAATGAAAC
CTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAAT
GGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATTT
TGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGATTGAAAAGTATGGATTCCCACCTGATC
TTACCCTCACCCCTCAAGAAAGCATCCAGCTTTATGATACCATGGCTCAAGTCTGGGAAACTTGGCCCAGGGCTCAGGAATTGTGTCCAG
AGGAATTCATTCTTTTTAAGAATAAGATAGTCATTAAGAAGTTGGATGCTAGAAAATATGAAGAAAACTTAAAGGCAGAATTGACAAATT
GGATTAAAAATGGCCAAGTGAAGAAGGTCAAAAGAGTACTGAAGAACCTTAGTCCGGATTCATTGTCTAGTTCAAAAGATATGGTGAAAA
TGTTTCCTCTTCTTGTTGAAAAGTTAAGACAAATGGATAAGTTGCCTGCAATATTTTTTTTGTTTAAGAATGATGATGTGGGAAAAAGAG
CTGGAAGTGTGTGCACTTTTCTGGAGAAGACAGAGACAAAAAGCCATCCCCACACTGAATGTCATAGTTATGTCTTTGCAATAGATGAAG
TACTTGAAAAAGTGAGGAAGACACAGAAAAGGATTAGCACTAAAAAAAACCCAAAGAAGGCTGAAAAACTGGAAAGAAAAAAAGTGTATA
GAGCTGAATATATTAATTTCCTGGAGAATCTGAAGATTCTGGAAATTTCTGAGGACTGCACGTATGCTGATGTCAAAGCCCTACACACTG
AAATTACCAGGAATAAAGACTCAACTTTGGAGAGGGTATTACCGCGAGTGCGATTTACAAGACACGGCAAAGAACTGAAGGCTTTAGCAC
AAAGGGGGATTGGATATCATCACAGCAGCATGTATTTTAAAGAAAAAGAGTTTGTTGAGATACTCTTTGTAAAAGGGCTTATTAGGGTAG
TGACAGCTACTGAAACACTTGCCTTAGGGATCCACATGCCATGCAAATCTGTTGTTTTTGCCCAAGACTCAGTCTATCTGGATGCTTTAA
ATTACAGACAGATCATGTGAACTCTCCTAGACTGGAATATGAAGACTGTGATTTTACAGAGAAAAGGAGTTTATCTCCATTTCATGACCT
TTTAGGATGTTGCTGTTTCAACTTTAAAAGCCATATTTTCCTTTTCTCAAGTATAGCTATAGACCATATCACCTTTTACCATGTTCTGTT
ATGAAAAACAGGAAGTCCCTGAGCTGGAATTTTTCAGTCTTTCTCTTTTTCATGTAGAGAGCAAAGTTTCTCTTAAGGGACTTTTGTTTC
CTTCAGAATTATGGTCTCCTTTTTTCTCTTCCTTGCCAAAATCACTAGTTTGGAAGAAATCCAACATCATTTATTTACTATGGACCACAA

>15693_15693_5_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000380026_DDX60L_chr4_169327857_ENST00000505890_length(amino acids)=566AA_BP=251
MKCRPRRVLAIFLGPVQPDRMAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI
IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLIEKYGFPPDLTLTPQESIQ
LYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLR
QMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRISTKKNPKKAEKLERKKVYRAEYINFLEN
LKILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALG

--------------------------------------------------------------
>15693_15693_6_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000380026_DDX60L_chr4_169327857_ENST00000511577_length(transcript)=4336nt_BP=782nt
AAATTTAAAGGCGGGGCGGCCTGTGAGCCCTGAAGTGCCGGCCGCGGAGGGTCCTGGCCATTTTCCTGGGACCAGTTCAGCCTGATAGGA
TGGCGGAGGAAGGAGCCGTGGCCGTCTGCGTGCGAGTGCGGCCGCTGAACAGCAGAGAAGAATCACTTGGAGAAACTGCCCAAGTTTACT
GGAAAACTGACAATAATGTCATTTATCAAGTTGATGGAAGTAAATCCTTCAATTTTGATCGTGTCTTTCATGGTAATGAAACTACCAAAA
ATGTGTATGAAGAAATAGCAGCACCAATCATCGATTCTGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAGACTGCTTCAG
GAAAAACATATACCATGATGGGTTCAGAAGATCATTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAAAATTAAGAAGTTTC
CTGATAGGGAATTTCTCTTACGTGTATCTTACATGGAAATATACAATGAAACCATTACAGATTTACTCTGTGGCACTCAAAAAATGAAAC
CTTTAATTATTCGAGAAGATGTCAATAGGAATGTGTATGTTGCTGATCTCACAGAAGAAGTTGTATATACATCAGAAATGGCTTTGAAAT
GGATTACAAAGGGAGAAAAGAGCAGGCATTATGGAGAAACAAAAATGAATCAAAGAAGCAGTCGTTCTCATACCATCTTTAGGATGATTT
TGGAAAGCAGAGAGAAGGGTGAACCTTCTAATTGTGAAGGATCTGTTAAGGTATCCCATTTGATTGAAAAGTATGGATTCCCACCTGATC
TTACCCTCACCCCTCAAGAAAGCATCCAGCTTTATGATACCATGGCTCAAGTCTGGGAAACTTGGCCCAGGGCTCAGGAATTGTGTCCAG
AGGAATTCATTCTTTTTAAGAATAAGATAGTCATTAAGAAGTTGGATGCTAGAAAATATGAAGAAAACTTAAAGGCAGAATTGACAAATT
GGATTAAAAATGGCCAAGTGAAGAAGGTCAAAAGAGTACTGAAGAACCTTAGTCCGGATTCATTGTCTAGTTCAAAAGATATGGTGAAAA
TGTTTCCTCTTCTTGTTGAAAAGTTAAGACAAATGGATAAGTTGCCTGCAATATTTTTTTTGTTTAAGAATGATGATGTGGGAAAAAGAG
CTGGAAGTGTGTGCACTTTTCTGGAGAAGACAGAGACAAAAAGCCATCCCCACACTGAATGTCATAGTTATGTCTTTGCAATAGATGAAG
TACTTGAAAAAGTGAGGAAGACACAGAAAAGGATCACTAAAAAAAACCCAAAGAAGGCTGAAAAACTGGAAAGAAAAAAAGTGTATAGAG
CTGAATATATTAATTTCCTGGAGAATCTGAAGATTCTGGAAATTTCTGAGGACTGCACGTATGCTGATGTCAAAGCCCTACACACTGAAA
TTACCAGGAATAAAGACTCAACTTTGGAGAGGGTATTACCGCGAGTGCGATTTACAAGACACGGCAAAGAACTGAAGGCTTTAGCACAAA
GGGGGATTGGATATCATCACAGCAGCATGTATTTTAAAGAAAAAGAGTTTGTTGAGATACTCTTTGTAAAAGGGCTTATTAGGGTAGTGA
CAGCTACTGAAACACTTGCCTTAGGGATCCACATGCCATGCAAATCTGTTGTTTTTGCCCAAGACTCAGTCTATCTGGATGCTTTAAATT
ACAGACAGATGTCTGGTCGTGCTGGAAGAAGAGGTCAAGACCTGCTTGGAAATGTGTATTTCTTTGATATCCCATTGCCCAAAATAAAAA
GACTCCTTGCATCCAGTGTTCCTGAGCTGAGAGGACAGTTCCCTCTCAGCATAACCCTGGTCCTGCGACTCATGCTGCTGGCTTCCAAGG
GAGATGACCCAGAGGATGCCAAGGCAAAGGTGTTGTCAGTGCTAAAGCATTCATTGCTGTCTTTTAAGAGACGAAGAGCCATGGAGACTT
TGAAACTTTACTTTTTGTTTTCCTTGCAGCTCCTTATCAAAGAGGACTATTTAAATAAAAAGGGTAATCCAAAGAAATTTGCAGGACTTG
CATCATATTTGCATGGTCATGAACCTTCAAATCTTGTTTTTGTAAATTTTCTCAAGAGAGGCCTTTTCCATAATCTCTGTAAGCCAGCCT
GGAAAGGCTCACAACAATTTTCCCAAGATGTGATGGAAAAGCTCGTGTTAGTATTGGCAAATTTGTTTGGAAGAAAATATATTCCAGCAA
AATTCCAAAATGCTAATTTAAGTTTTTCTCAGTCAAAGGTGATCCTTGCCGAACTCCCGGAGGATTTTAAAGCTGCTTTATATGAGTATA
ACCTGGCAGTAATGAAGGATTTTGCCTCCTTCCTGCTGATTGCTTCCAAGTCGGTGAACATGAAAAAAGAGCATCAACTCCCTTTGTCAA
GAATCAAATTCACAGGTAAAGAATGTGAAGACTCCCAACTCGTGTCTCACTTGATGAGCTGCAAGAAAGGAAGAGTAGCCATTTCACCAT
TTGTTTGTCTTTCGGGGAACACAGATAATGATTTGCTTCGACCAGAGACTATCAACCAGGTCATCCTGCGCACAGTCGGTGTTAGTGGCA
CTCAGGCTCCTCTGCTGTGGCCATGGAAATTAGATAACCGAGGAAGGAGAATGCCACTAAATGCATATGTGCTCAATTTCTATAAACACA
ACTGCTTGACAAGATTAGACCAAAAAAATGGGATGCGTATGGGACAGCTTTTAAAGTGTTTGAAAGATTTTGCATTCAACATTCAGGCTA
TCAGTGACTCCTTGAGTGAACTATGTGAAAATAAGCGTGACAATGTAGTCCTGGCATTTAAACAATTGAGTCAAACCTTTTATGAGAAAC
TTCAAGAAATGCAAATTCAAATGAGTCAAAATCATTTAGAATAACACCATGGAAAACTTTCAAGTCTGATTATGTGGTATTTATCCCTTT
GCAAGGAGAGATATAATTAAGCTTACACAATGAAATGGAAAAAATGTTTGTCTTGGAGTCAAACAGAATTAAACTCAGATATCAGCTCTG
CTATTTTCTAACTGAATGACTTTAAGTTATGTAATATATCTGAGCTTTAACTTCATTTTTGGCAAAACCGGAGTAAAAATGAATACCTCT
AGTTGTTTTGAGGATTAAATGAGATAATGTAAGAAAAGTGATTGGGATTGGGTGGTGACTTAATGAACGGTAGTGGTTTTTTTAGTAGTT
AATGTATAGCAAAATTAGTTTCACATTGTCAAGTTTTCAATACATCCCCAAGTTAATTGAATTTTAAATTAATGATCAATAAATCACAAA
GGACCCAAATCAATTCTGAACAACAATTTAGTTATGTAAGAAGACTTCTGAGATTACAAGAAACTCACTGCTGTGGACTGGATGTTTGTG
CCCTCCCCTCCAAAATTTTTATATTGAAATTCTAACCCTCAATGTGATGGTATTAGGAGATGATAGGTCATGAGGGTGGAGCTCCTTGGA
TGTAATTAGTGCCTTTAACAGAGAGACAAGAGAGCTTGTTCTCCAATCTCTGCTCACTACCACTGGATGATACAATGGGAAGATGGCCAT
CTGCAGACCAAGAAGCAAGCCCTCAACAGAACTGAATCTACTTACACCATGATCTTGAACTTTCCAGCCTCCAGGATTGTGAGAAATACA
TGTTTGTTGTTTAGCCATCTAGTCTGTGGTTTTCTGTTGAAGCAGTCTGAATTGACTAAAACAGTCACTTGGAGTAGTTATAAACCACTT
TCCTGTTGAAAGCAGAACATGCTGATTCAACTGTTTTGTTCAATAGCAATGATAGATTTTGTTTAAGTCCCCTACACTTTCTTATTTCTA
AATGATCAAGAGTACACTTCCTGGCAGTGATTAAGGAGTGTGTATCTAACAGAAAAAATATATATACCCTGTGAACCCGAATATGGAATT
CAGATTGTTTCTGCCCTCAGTATCATACTTAAAAAACAAGCATACAAACAAACATAAGGGAACAAACAGCAACCATAACAAAAACAAACC
TTTAAAGGTGCGTTTTTGCTGTGATAAATGAATACGGTACTCTGAAGGAGAAAAAAGTTTCTCAAATGAGCTTAAACTGCAAGTGATTTA
AAAATTAGAGAATATAATTCTTAAAGCTATTGAAAGTTTCAACCAGAAAACCTCAAGTGAATTTTGTATGTAAATGAAATCTTGAATGTA
AGTTCTGTGATTCTTTAAGCAAACAATTAGCTGAAAACTTGGTATTGTTGTAGTTTATGTAGTAAGTGACTTGGCACCCATCAGAAAATA

>15693_15693_6_CENPE-DDX60L_CENPE_chr4_104115386_ENST00000380026_DDX60L_chr4_169327857_ENST00000511577_length(amino acids)=964AA_BP=251
MKCRPRRVLAIFLGPVQPDRMAEEGAVAVCVRVRPLNSREESLGETAQVYWKTDNNVIYQVDGSKSFNFDRVFHGNETTKNVYEEIAAPI
IDSAIQGYNGTIFAYGQTASGKTYTMMGSEDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVNR
NVYVADLTEEVVYTSEMALKWITKGEKSRHYGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLIEKYGFPPDLTLTPQESIQ
LYDTMAQVWETWPRAQELCPEEFILFKNKIVIKKLDARKYEENLKAELTNWIKNGQVKKVKRVLKNLSPDSLSSSKDMVKMFPLLVEKLR
QMDKLPAIFFLFKNDDVGKRAGSVCTFLEKTETKSHPHTECHSYVFAIDEVLEKVRKTQKRITKKNPKKAEKLERKKVYRAEYINFLENL
KILEISEDCTYADVKALHTEITRNKDSTLERVLPRVRFTRHGKELKALAQRGIGYHHSSMYFKEKEFVEILFVKGLIRVVTATETLALGI
HMPCKSVVFAQDSVYLDALNYRQMSGRAGRRGQDLLGNVYFFDIPLPKIKRLLASSVPELRGQFPLSITLVLRLMLLASKGDDPEDAKAK
VLSVLKHSLLSFKRRRAMETLKLYFLFSLQLLIKEDYLNKKGNPKKFAGLASYLHGHEPSNLVFVNFLKRGLFHNLCKPAWKGSQQFSQD
VMEKLVLVLANLFGRKYIPAKFQNANLSFSQSKVILAELPEDFKAALYEYNLAVMKDFASFLLIASKSVNMKKEHQLPLSRIKFTGKECE
DSQLVSHLMSCKKGRVAISPFVCLSGNTDNDLLRPETINQVILRTVGVSGTQAPLLWPWKLDNRGRRMPLNAYVLNFYKHNCLTRLDQKN

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Fusion Gene PPI Analysis for CENPE-DDX60L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CENPE-DDX60L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CENPE-DDX60L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource