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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CENPF-TUBA1B (FusionGDB2 ID:15700) |
Fusion Gene Summary for CENPF-TUBA1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CENPF-TUBA1B | Fusion gene ID: 15700 | Hgene | Tgene | Gene symbol | CENPF | TUBA1B | Gene ID | 1063 | 10376 |
| Gene name | centromere protein F | tubulin alpha 1b | |
| Synonyms | CENF|CILD31|PRO1779|STROMS|hcp-1 | K-ALPHA-1 | |
| Cytomap | 1q41 | 12q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | centromere protein FAH antigenCENP-F kinetochore proteincell-cycle-dependent 350K nuclear proteincentromere protein F, 350/400kDakinetochore protein CENPFmitosin | tubulin alpha-1B chainalpha tubulinalpha-tubulin ubiquitoustubulin K-alpha-1tubulin alpha-ubiquitous chaintubulin, alpha, ubiquitous | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000366955, ENST00000467765, | ENST00000336023, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 14 X 15 X 4=840 |
| # samples | 5 | 19 | |
| ** MAII score | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/840*10)=-2.14438990933517 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CENPF [Title/Abstract] AND TUBA1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CENPF(214818615)-TUBA1B(49521789), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CENPF | GO:0015031 | protein transport | 12974617 |
| Hgene | CENPF | GO:0045892 | negative regulation of transcription, DNA-templated | 15677469 |
| Hgene | CENPF | GO:0051310 | metaphase plate congression | 15870278 |
| Fusion gene breakpoints across CENPF (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across TUBA1B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF245135 | CENPF | chr1 | 214818615 | + | TUBA1B | chr12 | 49521789 | - |
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Fusion Gene ORF analysis for CENPF-TUBA1B |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000366955 | ENST00000336023 | CENPF | chr1 | 214818615 | + | TUBA1B | chr12 | 49521789 | - |
| intron-3CDS | ENST00000467765 | ENST00000336023 | CENPF | chr1 | 214818615 | + | TUBA1B | chr12 | 49521789 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000366955 | CENPF | chr1 | 214818615 | + | ENST00000336023 | TUBA1B | chr12 | 49521789 | - | 7507 | 7282 | 168 | 5159 | 1663 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000366955 | ENST00000336023 | CENPF | chr1 | 214818615 | + | TUBA1B | chr12 | 49521789 | - | 0.005428053 | 0.994572 |
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Fusion Genomic Features for CENPF-TUBA1B |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CENPF-TUBA1B |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:214818615/chr12:49521789) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | TUBA1B | chr1:214818615 | chr12:49521789 | ENST00000336023 | 0 | 4 | 142_148 | 0 | 452.0 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 1196_1244 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 13_131 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 1549_1646 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 1890_2078 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2107_2891 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 280_685 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 899_989 | 0 | 3115.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2919_2936 | 0 | 3115.0 | Motif | Nuclear localization signal |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2111_2472 | 0 | 3115.0 | Region | Note=2 X 177 AA tandem repeats |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2392_2829 | 0 | 3115.0 | Region | Note=Sufficient for self-association |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2392_3017 | 0 | 3115.0 | Region | Note=Sufficient for centromere localization |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2831_3017 | 0 | 3115.0 | Region | Note=Sufficient for nuclear localization |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2111_2290 | 0 | 3115.0 | Repeat | Note=1 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2293_2472 | 0 | 3115.0 | Repeat | Note=2 |
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Fusion Gene Sequence for CENPF-TUBA1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >15700_15700_1_CENPF-TUBA1B_CENPF_chr1_214818615_ENST00000366955_TUBA1B_chr12_49521789_ENST00000336023_length(transcript)=7507nt_BP=7282nt AGAAGCGGGCGAATTGGGCACCGGTGGCGGCTGCGGGCAGTTTGAATTAGACTCTGGGCTCCAGCCCGCCGAAGCCGCGCCAGAACTGTA CTCTCCGAGAGGTCGTTTTCCCGTCCCCGAGAGCAAGTTTATTTACAAATGTTGGAGTAATAAAGAAGGCAGAACAAAATGAGCTGGGCT TTGGAAGAATGGAAAGAAGGGCTGCCTACAAGAGCTCTTCAGAAAATTCAAGAGCTTGAAGGACAGCTTGACAAACTGAAGAAGGAAAAG CAGCAAAGGCAGTTTCAGCTTGACAGTCTCGAGGCTGCGCTGCAGAAGCAAAAACAGAAGGTTGAAAATGAAAAAACCGAGGGTACAAAC CTGAAAAGGGAGAATCAAAGATTGATGGAAATATGTGAAAGTCTGGAGAAAACTAAGCAGAAGATTTCTCATGAACTTCAAGTCAAGGAG TCACAAGTGAATTTCCAGGAAGGACAACTGAATTCAGGCAAAAAACAAATAGAAAAACTGGAACAGGAACTTAAAAGGTGTAAATCTGAG CTTGAAAGAAGCCAACAAGCTGCGCAGTCTGCAGATGTCTCTCTGAATCCATGCAATACACCACAAAAAATTTTTACAACTCCACTAACA CCAAGTCAATATTATAGTGGTTCCAAGTATGAAGATCTAAAAGAAAAATATAATAAAGAGGTTGAAGAACGAAAAAGATTAGAGGCAGAG GTTAAAGCCTTGCAGGCTAAAAAAGCAAGCCAGACTCTTCCACAAGCCACCATGAATCACCGCGACATTGCCCGGCATCAGGCTTCATCA TCTGTGTTCTCATGGCAGCAAGAGAAGACCCCAAGTCATCTTTCATCTAATTCTCAAAGAACTCCAATTAGGAGAGATTTCTCTGCATCT TACTTTTCTGGGGAACAAGAGGTGACTCCAAGTCGATCAACTTTGCAAATAGGGAAAAGAGATGCTAATAGCAGTTTCTTTGACAATTCT AGCAGTCCTCATCTTTTGGATCAATTAAAAGCGCAGAATCAAGAGCTAAGAAACAAGATTAATGAGTTGGAACTACGCCTGCAAGGACAT GAAAAAGAAATGAAAGGCCAAGTGAATAAGTTTCAAGAACTCCAACTCCAACTGGAGAAAGCAAAAGTGGAATTAATTGAAAAAGAGAAA GTTTTGAACAAATGTAGGGATGAACTAGTGAGAACAACAGCACAATACGACCAGGCGTCAACCAAGTATACTGCATTGGAACAAAAACTG AAAAAATTGACGGAAGATTTGAGTTGTCAGCGACAAAATGCAGAAAGTGCCAGATGTTCTCTGGAACAGAAAATTAAGGAAAAAGAAAAG GAGTTTCAAGAGGAGCTCTCCCGTCAACAGCGTTCTTTCCAAACACTGGACCAGGAGTGCATCCAGATGAAGGCCAGACTCACCCAGGAG TTACAGCAAGCCAAGAATATGCACAACGTCCTGCAGGCTGAACTGGATAAACTCACATCAGTAAAGCAACAGCTAGAAAACAATTTGGAA GAGTTTAAGCAAAAGTTGTGCAGAGCTGAACAGGCGTTCCAGGCGAGTCAGATCAAGGAGAATGAGCTGAGGAGAAGCATGGAGGAAATG AAGAAGGAAAACAACCTCCTTAAGAGTCACTCTGAGCAAAAGGCCAGAGAAGTCTGCCACCTGGAGGCAGAACTCAAGAACATCAAACAG TGTTTAAATCAGAGCCAGAATTTTGCAGAAGAAATGAAAGCGAAGAATACCTCTCAGGAAACCATGTTAAGAGATCTTCAAGAAAAAATA AATCAGCAAGAAAACTCCTTGACTTTAGAAAAACTGAAGCTTGCTGTGGCTGATCTGGAAAAGCAGCGAGATTGTTCTCAAGACCTTTTG AAGAAAAGAGAACATCACATTGAACAACTTAATGATAAGTTAAGCAAGACAGAGAAAGAGTCCAAAGCCTTGCTGAGTGCTTTAGAGTTA AAAAAGAAAGAATATGAAGAATTGAAAGAAGAGAAAACTCTGTTTTCTTGTTGGAAAAGTGAAAACGAAAAACTTTTAACTCAGATGGAA TCAGAAAAGGAAAACTTGCAGAGTAAAATTAATCACTTGGAAACTTGTCTGAAGACACAGCAAATAAAAAGTCATGAATACAACGAGAGA GTAAGAACGCTGGAGATGGACAGAGAAAACCTAAGTGTCGAGATCAGAAACCTTCACAACGTGTTAGACAGTAAGTCAGTGGAGGTAGAG ACCCAGAAACTAGCTTATATGGAGCTACAGCAGAAAGCTGAGTTCTCAGATCAGAAACATCAGAAGGAAATAGAAAATATGTGTTTGAAG ACTTCTCAGCTTACTGGGCAAGTTGAAGATCTAGAACACAAGCTTCAGTTACTGTCAAATGAAATAATGGACAAAGACCGGTGTTACCAA GACTTGCATGCCGAATATGAGAGCCTCAGGGATCTGCTAAAATCCAAAGATGCTTCTCTGGTGACAAATGAAGATCATCAGAGAAGTCTT TTGGCTTTTGATCAGCAGCCTGCCATGCATCATTCCTTTGCAAATATAATTGGAGAACAAGGAAGCATGCCTTCAGAGAGGAGTGAATGT CGTTTAGAAGCAGACCAAAGTCCGAAAAATTCTGCCATCCTACAAAATAGAGTTGATTCACTTGAATTTTCATTAGAGTCTCAAAAACAG ATGAACTCAGACCTGCAAAAGCAGTGTGAAGAGTTGGTGCAAATCAAAGGAGAAATAGAAGAAAATCTCATGAAAGCAGAACAGATGCAT CAAAGTTTTGTGGCTGAAACAAGTCAGCGCATTAGTAAGTTACAGGAAGACACTTCTGCTCACCAGAATGTTGTTGCTGAAACCTTAAGT GCCCTTGAGAACAAGGAAAAAGAGCTGCAACTTTTAAATGATAAGGTAGAAACTGAGCAGGCAGAGATTCAAGAATTAAAAAAGAGCAAC CATCTACTTGAAGACTCTCTAAAGGAGCTACAACTTTTATCCGAAACCCTAAGCTTGGAGAAGAAAGAAATGAGTTCCATCATTTCTCTA AATAAAAGGGAAATTGAAGAGCTGACCCAAGAGAATGGGACTCTTAAGGAAATTAATGCATCCTTAAATCAAGAGAAGATGAACTTAATC CAGAAAAGTGAGAGTTTTGCAAACTATATAGATGAAAGGGAGAAAAGCATTTCAGAGTTATCTGATCAGTACAAGCAAGAAAAACTTATT TTACTACAAAGATGTGAAGAAACCGGAAATGCATATGAGGATCTTAGTCAAAAATACAAAGCAGCACAGGAAAAGAATTCTAAATTAGAA TGCTTGCTAAATGAATGCACTAGTCTTTGTGAAAATAGGAAAAATGAGTTGGAACAGCTAAAGGAAGCATTTGCAAAGGAACACCAAGAA TTCTTAACAAAATTAGCATTTGCTGAAGAAAGAAATCAGAATCTGATGCTAGAGTTGGAGACAGTGCAGCAAGCTCTGAGATCTGAGATG ACAGATAACCAAAACAATTCTAAGAGCGAGGCTGGTGGTTTAAAGCAAGAAATCATGACTTTAAAGGAAGAACAAAACAAAATGCAAAAG GAAGTTAATGACTTATTACAAGAGAATGAACAGCTGATGAAGGTAATGAAGACTAAACATGAATGTCAAAATCTAGAATCAGAACCAATT AGGAACTCTGTGAAAGAAAGAGAGAGTGAGAGAAATCAATGTAATTTTAAACCTCAGATGGATCTTGAAGTTAAAGAAATTTCTCTAGAT AGTTATAATGCGCAGTTGGTGCAATTAGAAGCTATGCTAAGAAATAAGGAATTAAAACTTCAGGAAAGTGAGAAGGAGAAGGAGTGCCTG CAGCATGAATTACAGACAATTAGAGGAGATCTTGAAACCAGCAATTTGCAAGACATGCAGTCACAAGAAATTAGTGGCCTTAAAGACTGT GAAATAGATGCGGAAGAAAAGTATATTTCAGGGCCTCATGAGTTGTCAACAAGTCAAAACGACAATGCACACCTTCAGTGCTCTCTGCAA ACAACAATGAACAAGCTGAATGAGCTAGAGAAAATATGTGAAATACTGCAGGCTGAAAAGTATGAACTCGTAACTGAGCTGAATGATTCA AGGTCAGAATGTATCACAGCAACTAGGAAAATGGCAGAAGAGGTAGGGAAACTACTAAATGAAGTTAAAATATTAAATGATGACAGTGGT CTTCTCCATGGTGAGTTAGTGGAAGACATACCAGGAGGTGAATTTGGTGAACAACCAAATGAACAGCACCCTGTGTCTTTGGCTCCATTG GACGAGAGTAATTCCTACGAGCACTTGACATTGTCAGACAAAGAAGTTCAAATGCACTTTGCCGAATTGCAAGAGAAATTCTTATCTTTA CAAAGTGAACACAAAATTTTACATGATCAGCACTGTCAGATGAGCTCTAAAATGTCAGAGCTGCAGACCTATGTTGACTCATTAAAGGCC GAAAATTTGGTCTTGTCAACGAATCTGAGAAACTTTCAAGGTGACTTGGTGAAGGAGATGCAGCTGGGCTTGGAGGAGGGGCTCGTTCCA TCCCTGTCATCCTCTTGTGTGCCTGACAGCTCTAGTCTTAGCAGTTTGGGAGACTCCTCCTTTTACAGAGCTCTTTTAGAACAGACAGGA GATATGTCTCTTTTGAGTAATTTAGAAGGGGCTGTTTCAGCAAACCAGTGCAGTGTAGATGAAGTATTTTGCAGCAGTCTGCAGGAGGAG AATCTGACCAGGAAAGAAACCCCTTCGGCCCCAGCGAAGGGTGTTGAAGAGCTTGAGTCCCTCTGTGAGGTGTACCGGCAGTCCCTCGAG AAGCTAGAAGAGAAAATGGAAAGTCAAGGGATTATGAAAAATAAGGAAATTCAAGAGCTCGAGCAGTTATTAAGTTCTGAAAGGCAAGAG CTTGACTGCCTTAGGAAGCAGTATTTGTCAGAAAATGAACAGTGGCAACAGAAGCTGACAAGCGTGACTCTGGAGATGGAGTCCAAGTTG GCGGCAGAAAAGAAACAGACGGAACAACTGTCACTTGAGCTGGAAGTAGCACGACTCCAGCTACAAGGTCTGGACTTAAGTTCTCGGTCT TTGCTTGGCATCGACACAGAAGATAAATGAGCTGAGTAGGATCAGATCGGAGAAAGCTAGCATTGAGCATGAAGCCCTCTACCTGGAGGC TGACTTAGAGGTAGTTCAAACAGAGAAGCTATGTTTAGAAAAAGACAATGAAAATAAGCAGAAGGTTATTGTCTGCCTTGAAGAAGAACT CTCAGTGGTCACAAGTGAGAGAAACCAGCTTCGTGGAGAATTAGATACTATGTCAAAAAAAACCACGGCACTGGATCAGTTGTCTGAAAA AATGAAGGAGAAAACACAAGAGCTTGAGTCTCATCAAAGTGAGTGTCTCCATTGCATTCAGGTGGCAGAGGCAGAGGTGAAGGAAAAGAC GGAACTCCTTCAGACTTTGTCCTCTGATGTGAGTGAGCTGTTAAAAGACAAAACTCATCTCCAGGAAAAGCTGCAGAGTTTGGAAAAGGA CTCACAGGCACTGTCTTTGACAAAATGTGAGCTGGAAAACCAAATTGCACAACTGAATAAAGAGAAAGAATTGCTTGTCAAGGAATCTGA AAGCCTGCAGGCCAGACTGAGTGAATCAGATTATGAAAAGCTGAATGTCTCCAAGGCCTTGGAGGCCGCACTGGTGGAGAAAGGTGAGTT CGCATTGAGGCTGAGCTCAACACAGGAGGAAGTGCATCAGCTGAGAAGAGGCATCGAGAAACTGAGAGTTCGCATTGAGGCCGATGAAAA GAAGCAGCTGCACATCGCAGAGAAACTGAAAGAACGCGAGCGGGAGAATGATTCACTTAAGGATAAAGTTGAGAACCTTGAAAGGGAATT GCAGATGTCAGAAGAAAACCAGGAGCTAGTGATTCTTGATGCCGAGAATTCCAAAGCAGAAGTAGAGACTCTAAAAACACAAATAGAAGA GATGGCCAGAAGCCTGAAAGTTTTTGAATTAGACCTTGTCACGTTAAGGTCTGAAAAAGAAAATCTGACAAAACAAATACAAGAAAAACA AGGTCAGTTGTCAGAACTAGACAAGTTACTCTCTTCATTTAAAAGTCTGTTAGAAGAAAAGGAGCAAGCAGAGATACAGATCAAAGAAGA ATCTAAAACTGCAGTGGAGATGCTTCAGAATCAGTTAAAGGAGCTAAATGAGGCAGTAGCAGCCTTGTGTGGTGACCAAGAAATTATGAA GGCCACAGAACAGAGTCTAGACCCACCAATAGAGGAAGAGCATCAGCTGAGAAATAGCATTGAAAAGCTGAGAGCCCGCCTAGAAGCTGA TGAAAAGAAGCAGCTCTGTGTCTTACAACAACTGAAGGAAAGTGAGCATCATGCAGATTTACTTAAGGGTAGAGTGGAGAACCTTGAAAG AGAGCTAGAGATAGCCAGGACAAACCAAGAGCATGCAGCTCTTGAGGCAGAGAATTCCAAAGGAGAGGTAGAGACCCTAAAAGCAAAAAT AGAAGGGATGACCCAAAGTCTGAGAGGTCTGGAATTAGATGTTGTTACTATAAGGTCAGAAAAAGAAAATCTGACAAATGAATTACAAAA AGAGCAAGAGCGAATATCTGAATTAGAAATAATAAATTCATCATTTGAAAATATTTTGCAAGAAAAAGAGCAAGAGAAAGTACAGATGAA AGAAAAATCAAGCACTGCCATGGAGATGCTTCAAACACAATTAAAAGAGCTCAATGAGAGAGTGGCAGCCCTGCATAATGACCAAGAAGC CTGTAAGGCCAAAGAGCAGAATCTTAGTAGTCAAGTAGAGTGTCTTGAACTTGAGAAGGCTCAGTTGCTACAAGGCCTTGATGAGGCCAA AAATAATTATATTGTTTTGCAATCTTCAGTGAATGGCCTCATTCAAGAAGTAGAAGATGGCAAGCAGAAACTGGAGAAGAAGGATGAAGA AATCAGTAGACTGAAAAATCAAATTCAAGACCAAGAGCAGCTTGTCTCTAAACTGTCCCAGGTGGAAGGAGAGCACCAACTTTGGAAGGA GCAAAACTTAGAACTGAGAAATCTGACAGTGGAATTGGAGCAGAAGATCCAAGTGCTACAATCCAAAAATGCCTCTTTGCAGGACACATT AGAAGTGCTGCAGAGTTCTTACAAGAATCTAGAGAATGAGCTTGAATTGACAAAAATGGACAAAATGTCCTTTGTTGAAAAATGTGGATT CTGTTGAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAATTATCCATTCCTTTTGGCCCTGCAGCATGTCATGCTCCCAGAATTTCAG CTTCAGCTTAACTGACAGACGTTAAAGCTTTCTGGTTAGATTGTTTTCACTTGGTGATCATGTCTTTTCCATGTGTACCTGTAATATTTT >15700_15700_1_CENPF-TUBA1B_CENPF_chr1_214818615_ENST00000366955_TUBA1B_chr12_49521789_ENST00000336023_length(amino acids)=1663AA_BP= MSWALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHEL QVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKR LEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSF FDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTAL EQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLE NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDL QEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN MCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK MNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAK EHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLE SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISG LKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILN DDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVD SLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSS LQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEM -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CENPF-TUBA1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 2026_2351 | 0 | 3115.0 | NDE1 and NDEL1 |
| Hgene | CENPF | chr1:214818615 | chr12:49521789 | ENST00000366955 | + | 1 | 20 | 1_481 | 0 | 3115.0 | SNAP25 and required for localization to the cytoplasm |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CENPF-TUBA1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CENPF-TUBA1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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