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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CENPT-CENPT (FusionGDB2 ID:15737)

Fusion Gene Summary for CENPT-CENPT

check button Fusion gene summary
Fusion gene informationFusion gene name: CENPT-CENPT
Fusion gene ID: 15737
HgeneTgene
Gene symbol

CENPT

CENPT

Gene ID

80152

80152

Gene namecentromere protein Tcentromere protein T
SynonymsC16orf56|CENP-T|SSMGAC16orf56|CENP-T|SSMGA
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptioncentromere protein Tinterphase centromere complex protein 22centromere protein Tinterphase centromere complex protein 22
Modification date2020032020200320
UniProtAcc

Q96BT3

Q96BT3

Ensembl transtripts involved in fusion geneENST00000219172, ENST00000440851, 
ENST00000445712, ENST00000562787, 
ENST00000562947, ENST00000564817, 
ENST00000219172, ENST00000440851, 
ENST00000562787, ENST00000564817, 
ENST00000445712, ENST00000562947, 
Fusion gene scores* DoF score4 X 5 X 3=606 X 7 X 3=126
# samples 56
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/126*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CENPT [Title/Abstract] AND CENPT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCENPT(67865743)-CENPT(67866416), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CENPT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CENPT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABP209496CENPTchr16

67865743

-CENPTchr16

67866416

-


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Fusion Gene ORF analysis for CENPT-CENPT

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000219172ENST00000219172CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000219172ENST00000440851CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000219172ENST00000562787CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000219172ENST00000564817CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000440851ENST00000219172CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000440851ENST00000440851CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000440851ENST00000562787CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000440851ENST00000564817CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000445712ENST00000219172CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000445712ENST00000440851CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000445712ENST00000562787CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000445712ENST00000564817CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562787ENST00000219172CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562787ENST00000440851CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562787ENST00000562787CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562787ENST00000564817CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562947ENST00000219172CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562947ENST00000440851CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562947ENST00000562787CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000562947ENST00000564817CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000564817ENST00000219172CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000564817ENST00000440851CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000564817ENST00000562787CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-3CDSENST00000564817ENST00000564817CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-5UTRENST00000219172ENST00000445712CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-5UTRENST00000440851ENST00000445712CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-5UTRENST00000445712ENST00000445712CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-5UTRENST00000562787ENST00000445712CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-5UTRENST00000562947ENST00000445712CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-5UTRENST00000564817ENST00000445712CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-intronENST00000219172ENST00000562947CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-intronENST00000440851ENST00000562947CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-intronENST00000445712ENST00000562947CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-intronENST00000562787ENST00000562947CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-intronENST00000562947ENST00000562947CENPTchr16

67865743

-CENPTchr16

67866416

-
intron-intronENST00000564817ENST00000562947CENPTchr16

67865743

-CENPTchr16

67866416

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CENPT-CENPT


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CENPT-CENPT


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67865743/:67866416)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CENPT

Q96BT3

CENPT

Q96BT3

FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:21529714, ECO:0000269|PubMed:21695110}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CENPT-CENPT


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CENPT-CENPT


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CENPT-CENPT


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CENPT-CENPT


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource