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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP112-ARAP1 (FusionGDB2 ID:15753)

Fusion Gene Summary for CEP112-ARAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP112-ARAP1
Fusion gene ID: 15753
HgeneTgene
Gene symbol

CEP112

ARAP1

Gene ID

201134

116985

Gene namecentrosomal protein 112ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
SynonymsCCDC46|MACOCOCENTD2
Cytomap

17q24.1

11q13.4

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1centaurin-delta-2cnt-d2
Modification date2020031320200313
UniProtAcc

Q8N8E3

Q96P48

Ensembl transtripts involved in fusion geneENST00000317442, ENST00000392769, 
ENST00000535342, ENST00000537949, 
ENST00000541355, ENST00000580482, 
ENST00000334211, ENST00000359373, 
ENST00000393605, ENST00000393609, 
ENST00000426523, ENST00000429686, 
ENST00000455638, ENST00000495878, 
Fusion gene scores* DoF score10 X 10 X 4=4004 X 5 X 2=40
# samples 104
** MAII scorelog2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/40*10)=0
Context

PubMed: CEP112 [Title/Abstract] AND ARAP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP112(63923127)-ARAP1(72442333), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARAP1

GO:0043547

positive regulation of GTPase activity

11804590


check buttonFusion gene breakpoints across CEP112 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ARAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI659670CEP112chr17

63923127

+ARAP1chr11

72442333

+


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Fusion Gene ORF analysis for CEP112-ARAP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000317442ENST00000334211CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000359373CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000393605CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000393609CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000426523CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000429686CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000455638CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000317442ENST00000495878CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000334211CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000359373CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000393605CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000393609CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000426523CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000429686CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000455638CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000392769ENST00000495878CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000334211CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000359373CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000393605CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000393609CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000426523CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000429686CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000455638CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000535342ENST00000495878CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000334211CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000359373CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000393605CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000393609CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000426523CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000429686CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000455638CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000537949ENST00000495878CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000334211CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000359373CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000393605CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000393609CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000426523CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000429686CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000455638CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000541355ENST00000495878CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000334211CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000359373CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000393605CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000393609CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000426523CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000429686CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000455638CEP112chr17

63923127

+ARAP1chr11

72442333

+
intron-intronENST00000580482ENST00000495878CEP112chr17

63923127

+ARAP1chr11

72442333

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CEP112-ARAP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP112-ARAP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:63923127/:72442333)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP112

Q8N8E3

ARAP1

Q96P48

FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11804590}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CEP112-ARAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CEP112-ARAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP112-ARAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP112-ARAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource