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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP112-LRBA (FusionGDB2 ID:15759)

Fusion Gene Summary for CEP112-LRBA

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP112-LRBA
Fusion gene ID: 15759
HgeneTgene
Gene symbol

CEP112

LRBA

Gene ID

201134

987

Gene namecentrosomal protein 112LPS responsive beige-like anchor protein
SynonymsCCDC46|MACOCOBGL|CDC4L|CVID8|LAB300|LBA
Cytomap

17q24.1

4q31.3

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 112 kDacentrosomal protein 112kDacoiled-coil domain-containing protein 46lipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containing
Modification date2020031320200320
UniProtAcc

Q8N8E3

P50851

Ensembl transtripts involved in fusion geneENST00000392769, ENST00000535342, 
ENST00000537949, ENST00000317442, 
ENST00000541355, ENST00000580482, 
ENST00000357115, ENST00000503716, 
ENST00000507224, ENST00000510413, 
ENST00000535741, 
Fusion gene scores* DoF score10 X 10 X 4=40025 X 25 X 10=6250
# samples 1027
** MAII scorelog2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/6250*10)=-4.53282487738598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP112 [Title/Abstract] AND LRBA [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP112(64171161)-LRBA(151683001), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CEP112 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRBA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACR627301CEP112chr17

64171161

-LRBAchr4

151683001

-


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Fusion Gene ORF analysis for CEP112-LRBA

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000392769ENST00000357115CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000392769ENST00000503716CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000392769ENST00000507224CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000535342ENST00000357115CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000535342ENST00000503716CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000535342ENST00000507224CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000537949ENST00000357115CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000537949ENST00000503716CEP112chr17

64171161

-LRBAchr4

151683001

-
5CDS-intronENST00000537949ENST00000507224CEP112chr17

64171161

-LRBAchr4

151683001

-
Frame-shiftENST00000535342ENST00000510413CEP112chr17

64171161

-LRBAchr4

151683001

-
Frame-shiftENST00000535342ENST00000535741CEP112chr17

64171161

-LRBAchr4

151683001

-
In-frameENST00000392769ENST00000510413CEP112chr17

64171161

-LRBAchr4

151683001

-
In-frameENST00000392769ENST00000535741CEP112chr17

64171161

-LRBAchr4

151683001

-
In-frameENST00000537949ENST00000510413CEP112chr17

64171161

-LRBAchr4

151683001

-
In-frameENST00000537949ENST00000535741CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-3CDSENST00000317442ENST00000510413CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-3CDSENST00000317442ENST00000535741CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-3CDSENST00000541355ENST00000510413CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-3CDSENST00000541355ENST00000535741CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-3CDSENST00000580482ENST00000510413CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-3CDSENST00000580482ENST00000535741CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000317442ENST00000357115CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000317442ENST00000503716CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000317442ENST00000507224CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000541355ENST00000357115CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000541355ENST00000503716CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000541355ENST00000507224CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000580482ENST00000357115CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000580482ENST00000503716CEP112chr17

64171161

-LRBAchr4

151683001

-
intron-intronENST00000580482ENST00000507224CEP112chr17

64171161

-LRBAchr4

151683001

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392769CEP112chr1764171161-ENST00000535741LRBAchr4151683001-49486897553667970
ENST00000392769CEP112chr1764171161-ENST00000510413LRBAchr4151683001-48566897553664969
ENST00000537949CEP112chr1764171161-ENST00000535741LRBAchr4151683001-47765175833495970
ENST00000537949CEP112chr1764171161-ENST00000510413LRBAchr4151683001-46845175833492969

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392769ENST00000535741CEP112chr1764171161-LRBAchr4151683001-0.0005084960.99949145
ENST00000392769ENST00000510413CEP112chr1764171161-LRBAchr4151683001-0.0005317650.99946827
ENST00000537949ENST00000535741CEP112chr1764171161-LRBAchr4151683001-0.0004779510.9995221
ENST00000537949ENST00000510413CEP112chr1764171161-LRBAchr4151683001-0.0005027590.9994972

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Fusion Genomic Features for CEP112-LRBA


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP112-LRBA


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:64171161/chr4:151683001)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP112

Q8N8E3

LRBA

P50851

FUNCTION: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533581990_199418602864.0Compositional biasNote=Poly-Arg
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333571990_199418602852.0Compositional biasNote=Poly-Arg
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582073_218118602864.0DomainBEACH-type PH
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582200_248918602864.0DomainBEACH
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572073_218118602852.0DomainBEACH-type PH
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572200_248918602852.0DomainBEACH
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582591_263318602864.0RepeatNote=WD 2
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582636_267918602864.0RepeatNote=WD 3
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582695_273518602864.0RepeatNote=WD 4
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582777_281618602864.0RepeatNote=WD 5
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533582819_285818602864.0RepeatNote=WD 6
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572591_263318602852.0RepeatNote=WD 2
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572636_267918602852.0RepeatNote=WD 3
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572695_273518602852.0RepeatNote=WD 4
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572777_281618602852.0RepeatNote=WD 5
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333572819_285818602852.0RepeatNote=WD 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP112chr17:64171161chr4:151683001ENST00000317442-17277_9540212.0Coiled coilOntology_term=ECO:0000255
HgeneCEP112chr17:64171161chr4:151683001ENST00000392769-427277_954156956.0Coiled coilOntology_term=ECO:0000255
HgeneCEP112chr17:64171161chr4:151683001ENST00000535342-427277_954156956.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533581006_105318602864.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333571006_105318602852.0Coiled coilOntology_term=ECO:0000255
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533581301_134318602864.0RepeatNote=WD 1
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333571301_134318602852.0RepeatNote=WD 1
TgeneLRBAchr17:64171161chr4:151683001ENST0000035711533581531_154818602864.0TransmembraneHelical
TgeneLRBAchr17:64171161chr4:151683001ENST0000051041333571531_154818602852.0TransmembraneHelical


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Fusion Gene Sequence for CEP112-LRBA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15759_15759_1_CEP112-LRBA_CEP112_chr17_64171161_ENST00000392769_LRBA_chr4_151683001_ENST00000510413_length(transcript)=4856nt_BP=689nt
GGGCCCGTTCTCCGGGCCTGGGGGGCGCGCGCCCCTGGGGTCCCGGCGCTGCCCGCTGTGGTGTCCCCGGCAGGCAGAGCGCGATCCAGG
CCGGGACGACTTGGGAAAGTTCTAAGTAAAGTTTGATCAGCCGGTTTGATCGGTCTGACGTGGTCCAAGAGTCTGACCCAAGGGTTTGCG
ACTGGGAGAGGAAATCTGTGTCCTGGACAAGATTGGATTATGGAAGTGGGAAGTGAAGAAGAAAAATGGGAGAAGCTGGATGCAGAATTT
GATCACTTTGTGGTTGATATGAAGCCCTTTGTTCTAAAATTACCTCATAGGACAGAACGGCAGAGGTGTGCTCTTTGGATTAGAAAGCTG
TGCGAACCTTCAGGAACAGGTGCAGGAATAATGGGGAGGAAGAATCGGAACCTGTATGCAAAATTGTTATTGCATATGCTTAAACGAGGT
GCGCTTGAAGGCCCTTTTACACACCGACCTGAACCCGGGACACTAAAAATTCTACCTTCATACATGTCCATCTATTTTGATGAACCAAAT
CCAGCACGAGCAAAAGGTTCAAGCCCAGAGGGATTACCAGCCTGGGTACTGGGTGAGCTGGAGACAAGTGAACACAAATTAAATGAATCA
TGGAAACTCTCTTCTGGAGAAGATAACACTTTAGTACAGTCGCCAACTGATGTCTACAGGAGTGGCAAAATTCTATTCAGAAGAATGCAG
GCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAAT
TTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAG
ATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTATCAACATTC
TCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGC
GCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGATGAAGATA
TCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATA
CTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTG
TAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGA
TCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAG
CCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTC
GTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGA
CCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGACTTAAATC
AGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGC
CAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATG
GTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCA
AATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCC
CTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCG
AACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTGGCCCTGGAGAGTGAATTTGTTTCCTGCCAGCTTCACC
AATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGAGCCCTCAATGTGTTCTATTACTTGACCTATGAAGGAG
CTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCTCAAATCCGAAGTTTTGGACAGACTCCTTCTCAACTAC
TCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATGTTCACAGACAAAGCCCAGCAGGATGTTATCATGGTCC
TCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCTGGTTTGGCAACTCCCGCTGTGATCACAGTCACTGCTA
ACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCTGTACAAGACCAGCCATACCAGCTGCCAGTGGAAATCG
ATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTTTTAGACCAAAGTATTCAAGTGCATTCCCAGTGCTTTG
TCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGTTTCAGAGTCTATTCTACAGACACAGGAAGATTGATCC
AAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCATATATTGGGGGAAATTGCTACATTCTCTCAGGGTCAC
GTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGAGATAACCCAGGTGAGACTGCTGCTCCTCGGGCCATTT
TGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGCCTGGTGTTGAGTGGTTCACAAGAAGGACCATGTCTCA
TACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGCCTGAAACCAAAACTCATTCAGGCTTCAAGAGAGGGTC
ATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGAAAACTCCAGGCCACGATGGAAACAGATGATAACATAA
GAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGAGGAGTGGTCGTGGTCCGGCAGGTGTCGGACCTCAAGC
AGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCTTACGACCAGAGGTGCATCATTTCTGGCATGGCTTCAG
GAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAAACCCGCTACTGATGGTGACAGCTGTACATCAACTCTG
CCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGAATGTAACTTAAATTTGCTCAAAGAAGCAAAATATTTT
TTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGGGGGATTAGCAAAGCAGAAAACTGGCTGCTGGGTTCTG
TAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAATTATGGAAACATACAGTGGAGCAAGTAAACCACTTAT
TCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAATAGGATTTTCACAGTGGGGAAGTGGGTTACAATATTG
GAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTGTGCTTCTTCAGCACTAATATTTCTGGGATTTAAATAG
TAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCTATCAATATTGTTCTTCAAGCATGTTTTAGACCTAGAA
AAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAATTTATAGCAAGTGTGAAATAGTTACCATTTTTTCCTG
ATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCTCACAACATTTGTTTTTCTTTTAAAGTAAATGCAAGTA
CCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACTGTTGTTTTGTTGGGGCACCCCCTTCCCTCCCCGGGTT
TGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTGTTATTAAACTATCATCTCCACCTTCCTTTTGATTAGC
AATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTTTCTAGTAGATTACTGTGTGGAATTCTGTGAAAAATAT
TTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTGATCTCTATTTCTCTTGCAACAGACTTCAAGTGGTCCC

>15759_15759_1_CEP112-LRBA_CEP112_chr17_64171161_ENST00000392769_LRBA_chr4_151683001_ENST00000510413_length(amino acids)=969AA_BP=
MLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSA
VSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLEN
LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAV
MFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNY
ESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSI
SRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQ
GPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHV
AANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVC
GFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGETAAPRAILTGHDYEVTCAA
VCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYL

--------------------------------------------------------------
>15759_15759_2_CEP112-LRBA_CEP112_chr17_64171161_ENST00000392769_LRBA_chr4_151683001_ENST00000535741_length(transcript)=4948nt_BP=689nt
GGGCCCGTTCTCCGGGCCTGGGGGGCGCGCGCCCCTGGGGTCCCGGCGCTGCCCGCTGTGGTGTCCCCGGCAGGCAGAGCGCGATCCAGG
CCGGGACGACTTGGGAAAGTTCTAAGTAAAGTTTGATCAGCCGGTTTGATCGGTCTGACGTGGTCCAAGAGTCTGACCCAAGGGTTTGCG
ACTGGGAGAGGAAATCTGTGTCCTGGACAAGATTGGATTATGGAAGTGGGAAGTGAAGAAGAAAAATGGGAGAAGCTGGATGCAGAATTT
GATCACTTTGTGGTTGATATGAAGCCCTTTGTTCTAAAATTACCTCATAGGACAGAACGGCAGAGGTGTGCTCTTTGGATTAGAAAGCTG
TGCGAACCTTCAGGAACAGGTGCAGGAATAATGGGGAGGAAGAATCGGAACCTGTATGCAAAATTGTTATTGCATATGCTTAAACGAGGT
GCGCTTGAAGGCCCTTTTACACACCGACCTGAACCCGGGACACTAAAAATTCTACCTTCATACATGTCCATCTATTTTGATGAACCAAAT
CCAGCACGAGCAAAAGGTTCAAGCCCAGAGGGATTACCAGCCTGGGTACTGGGTGAGCTGGAGACAAGTGAACACAAATTAAATGAATCA
TGGAAACTCTCTTCTGGAGAAGATAACACTTTAGTACAGTCGCCAACTGATGTCTACAGGAGTGGCAAAATTCTATTCAGAAGAATGCAG
GCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGAAGCTGAAT
TTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAAACGAGAAG
ATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTATCAACATTC
TCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGACTTGCGGC
GCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGATGAAGATA
TCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGATGATGATA
CTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCCCTCTGTTG
TAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGACCCCAAGA
TCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCAAAATACAG
CCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTATCTACCTC
GTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTCTAATATGA
CCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGACTTAAATC
AGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTTGTCCAAGC
CAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTTTCACTATG
GTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCAAGGAGGCA
AATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGAGTTGATCC
CTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTCTGATGTCG
AACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTGGCCCTGGAGAGTGAATTTGTTTCCTGCCAGCTTCACC
AATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGAGCCCTCAATGTGTTCTATTACTTGACCTATGAAGGAG
CTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCTCAAATCCGAAGTTTTGGACAGACTCCTTCTCAACTAC
TCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATGTTCACAGACAAAGCCCAGCAGGATGTTATCATGGTCC
TCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCTGGTTTGGCAACTCCCGCTGTGATCACAGTCACTGCTA
ACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCTGTACAAGACCAGCCATACCAGCTGCCAGTGGAAATCG
ATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTTTTAGACCAAAGTATTCAAGTGCATTCCCAGTGCTTTG
TCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGTTTCAGAGTCTATTCTACAGACACAGGAAGATTGATCC
AAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCATATATTGGGGGAAATTGCTACATTCTCTCAGGGTCAC
GTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGAGATAACCCAGGCAGTGAGACTGCTGCTCCTCGGGCCA
TTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGCCTGGTGTTGAGTGGTTCACAAGAAGGACCATGTC
TCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGCCTGAAACCAAAACTCATTCAGGCTTCAAGAGAGG
GTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGAAAACTCCAGGCCACGATGGAAACAGATGATAACA
TAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGAGGAGTGGTCGTGGTCCGGCAGGTGTCGGACCTCA
AGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCTTACGACCAGAGGTGCATCATTTCTGGCATGGCTT
CAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAAACCCGCTACTGATGGTGACAGCTGTACATCAACT
CTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGAATGTAACTTAAATTTGCTCAAAGAAGCAAAATAT
TTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGGGGGATTAGCAAAGCAGAAAACTGGCTGCTGGGTT
CTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAATTATGGAAACATACAGTGGAGCAAGTAAACCACT
TATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAATAGGATTTTCACAGTGGGGAAGTGGGTTACAATA
TTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTGTGCTTCTTCAGCACTAATATTTCTGGGATTTAAA
TAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCTATCAATATTGTTCTTCAAGCATGTTTTAGACCTA
GAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAATTTATAGCAAGTGTGAAATAGTTACCATTTTTTC
CTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCTCACAACATTTGTTTTTCTTTTAAAGTAAATGCAA
GTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACTGTTGTTTTGTTGGGGCACCCCCTTCCCTCCCCGG
GTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTGTTATTAAACTATCATCTCCACCTTCCTTTTGATT
AGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTTTCTAGTAGATTACTGTGTGGAATTCTGTGAAAAA
TATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTGATCTCTATTTCTCTTGCAACAGACTTCAAGTGGT
CCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAATGAACAATTCAGTTTGACAGAAAAAGCTGAATAAAATG

>15759_15759_2_CEP112-LRBA_CEP112_chr17_64171161_ENST00000392769_LRBA_chr4_151683001_ENST00000535741_length(amino acids)=970AA_BP=
MLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSA
VSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLEN
LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAV
MFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNY
ESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSI
SRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQ
GPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHV
AANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVC
GFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCA
AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQY

--------------------------------------------------------------
>15759_15759_3_CEP112-LRBA_CEP112_chr17_64171161_ENST00000537949_LRBA_chr4_151683001_ENST00000510413_length(transcript)=4684nt_BP=517nt
GGTTTGCGACTGGGAGAGGAAATCTGTGTCCTGGACAAGATTGGATTATGGAAGTGGGAAGTGAAGAAGAAAAATGGGAGAAGCTGGATG
CAGAATTTGATCACTTTGTGGTTGATATGAAGCCCTTTGTTCTAAAATTACCTCATAGGACAGAACGGCAGAGGTGTGCTCTTTGGATTA
GAAAGCTGTGCGAACCTTCAGGAACAGGTGCAGGAATAATGGGGAGGAAGAATCGGAACCTGTATGCAAAATTGTTATTGCATATGCTTA
AACGAGGTGCGCTTGAAGGCCCTTTTACACACCGACCTGAACCCGGGACACTAAAAATTCTACCTTCATACATGTCCATCTATTTTGATG
AACCAAATCCAGCACGAGCAAAAGGTTCAAGCCCAGAGGGATTACCAGCCTGGGTACTGGGTGAGCTGGAGACAAGTGAACACAAATTAA
ATGAATCATGGAAACTCTCTTCTGGAGAAGATAACACTTTAGTACAGTCGCCAACTGATGTCTACAGGAGTGGCAAAATTCTATTCAGAA
GAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGA
AGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAA
ACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTAT
CAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGA
CTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGA
TGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGA
TGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCC
CTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGA
CCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCA
AAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTA
TCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTC
TAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGA
CTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTT
GTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTT
TCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCA
AGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGA
GTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTC
TGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTGGCCCTGGAGAGTGAATTTGTTTCCTGCCA
GCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGAGCCCTCAATGTGTTCTATTACTTGACCTA
TGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCTCAAATCCGAAGTTTTGGACAGACTCCTTC
TCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATGTTCACAGACAAAGCCCAGCAGGATGTTAT
CATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCTGGTTTGGCAACTCCCGCTGTGATCACAGT
CACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCTGTACAAGACCAGCCATACCAGCTGCCAGT
GGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTTTTAGACCAAAGTATTCAAGTGCATTCCCA
GTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGTTTCAGAGTCTATTCTACAGACACAGGAAG
ATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCATATATTGGGGGAAATTGCTACATTCTCTC
AGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGAGATAACCCAGGTGAGACTGCTGCTCCTCG
GGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGCCTGGTGTTGAGTGGTTCACAAGAAGGACC
ATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGCCTGAAACCAAAACTCATTCAGGCTTCAAG
AGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGAAAACTCCAGGCCACGATGGAAACAGATGA
TAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGAGGAGTGGTCGTGGTCCGGCAGGTGTCGGA
CCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCTTACGACCAGAGGTGCATCATTTCTGGCAT
GGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAAACCCGCTACTGATGGTGACAGCTGTACAT
CAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGAATGTAACTTAAATTTGCTCAAAGAAGCAA
AATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGGGGGATTAGCAAAGCAGAAAACTGGCTGCT
GGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAATTATGGAAACATACAGTGGAGCAAGTAAA
CCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAATAGGATTTTCACAGTGGGGAAGTGGGTTA
CAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTGTGCTTCTTCAGCACTAATATTTCTGGGAT
TTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCTATCAATATTGTTCTTCAAGCATGTTTTAG
ACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAATTTATAGCAAGTGTGAAATAGTTACCATT
TTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCTCACAACATTTGTTTTTCTTTTAAAGTAAA
TGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACTGTTGTTTTGTTGGGGCACCCCCTTCCCTC
CCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTGTTATTAAACTATCATCTCCACCTTCCTTT
TGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTTTCTAGTAGATTACTGTGTGGAATTCTGTG
AAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTGATCTCTATTTCTCTTGCAACAGACTTCAA
GTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAATGAACAATTCAGTTTGACAGAAAAAGCTGAATA

>15759_15759_3_CEP112-LRBA_CEP112_chr17_64171161_ENST00000537949_LRBA_chr4_151683001_ENST00000510413_length(amino acids)=969AA_BP=
MLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSA
VSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLEN
LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAV
MFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNY
ESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSI
SRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQ
GPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHV
AANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVC
GFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGETAAPRAILTGHDYEVTCAA
VCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQYL

--------------------------------------------------------------
>15759_15759_4_CEP112-LRBA_CEP112_chr17_64171161_ENST00000537949_LRBA_chr4_151683001_ENST00000535741_length(transcript)=4776nt_BP=517nt
GGTTTGCGACTGGGAGAGGAAATCTGTGTCCTGGACAAGATTGGATTATGGAAGTGGGAAGTGAAGAAGAAAAATGGGAGAAGCTGGATG
CAGAATTTGATCACTTTGTGGTTGATATGAAGCCCTTTGTTCTAAAATTACCTCATAGGACAGAACGGCAGAGGTGTGCTCTTTGGATTA
GAAAGCTGTGCGAACCTTCAGGAACAGGTGCAGGAATAATGGGGAGGAAGAATCGGAACCTGTATGCAAAATTGTTATTGCATATGCTTA
AACGAGGTGCGCTTGAAGGCCCTTTTACACACCGACCTGAACCCGGGACACTAAAAATTCTACCTTCATACATGTCCATCTATTTTGATG
AACCAAATCCAGCACGAGCAAAAGGTTCAAGCCCAGAGGGATTACCAGCCTGGGTACTGGGTGAGCTGGAGACAAGTGAACACAAATTAA
ATGAATCATGGAAACTCTCTTCTGGAGAAGATAACACTTTAGTACAGTCGCCAACTGATGTCTACAGGAGTGGCAAAATTCTATTCAGAA
GAATGCAGGCCTTGCTTTTATCGAACTTGTCAATGAAGGAAGGTTGCTTAGCCAGACAATGAAGGATCATCTAGTAAGAGTAGCAAATGA
AGCTGAATTTATCCTGAGCAGGCAGAGAGCAGAAGATATTCACAGACATGCGGAATTTGAGTCACTGTGTGCCCAGTATTCTGCAGACAA
ACGAGAAGATGAGAAGATGTGTGATCATTTGATAAGAGCAGCAAAATATCGTGACCACGTGACAGCAACTCAACTAATCCAGAAAATTAT
CAACATTCTCACAGACAAGCATGGAGCCTGGGGAAATTCTGCAGTGAGTCGTCCTCTTGAGTTCTGGCGCCTTGACTACTGGGAAGATGA
CTTGCGGCGCCGGCGACGATTTGTGCGTAACCCTCTAGGATCGACACATCCTGAAGCGACACTAAAAACAGCCGTGGAACATGCCACAGA
TGAAGATATCCTTGCTAAAGGAAAACAGTCCATCAGGAGTCAGGCTTTAGGAAATCAGAACTCAGAAAACGAGATCCTCCTGGAAGGCGA
TGATGATACTCTGTCATCCGTGGATGAGAAAGATTTAGAGAATCTTGCCGGTCCTGTTAGCCTGAGCACACCAGCTCAGCTTGTGGCCCC
CTCTGTTGTAGTAAAGGGCACTCTTTCTGTCACCTCCTCCGAACTCTATTTTGAGGTGGATGAAGAGGATCCTAACTTCAAAAAAATCGA
CCCCAAGATCTTGGCATATACAGAAGGGCTGCATGGAAAATGGCTGTTCACAGAGATACGATCAATCTTTTCTCGTCGTTATCTTTTGCA
AAATACAGCCCTGGAGATCTTTATGGCAAACAGAGTTGCTGTGATGTTCAACTTCCCAGACCCTGCAACAGTAAAGAAAGTGGTTAACTA
TCTACCTCGTGTTGGCGTTGGAACAAGTTTTGGATTGCCTCAAACCAGACGTATTTCATTAGCTAGTCCACGTCAGCTTTTTAAGGCTTC
TAATATGACCCAGCGATGGCAACACAGAGAGATATCTAATTTTGAGTACTTGATGTTTCTCAACACGATAGCAGGACGGAGTTATAATGA
CTTAAATCAGTATCCAGTGTTTCCTTGGGTCATCACTAATTATGAATCAGAAGAACTGGATCTTACCTTGCCCACCAACTTCAGAGATTT
GTCCAAGCCAATAGGAGCTCTGAACCCAAAAAGAGCAGCATTCTTCGCTGAGCGTTATGAATCATGGGAAGATGATCAAGTTCCAAAGTT
TCACTATGGTACTCATTACTCAACTGCAAGTTTTGTTCTTGCATGGCTGCTAAGAATAGAACCCTTTACAACTTATTTCCTAAATTTGCA
AGGAGGCAAATTTGATCATGCAGATCGAACTTTTTCATCAATTTCCAGAGCTTGGCGAAACAGTCAGCGTGATACCTCTGATATTAAGGA
GTTGATCCCTGAATTTTATTATCTCCCTGAGATGTTTGTCAACTTCAATAATTATAATCTTGGAGTGATGGATGATGGGACAGTAGTGTC
TGATGTCGAACTTCCTCCTTGGGCCAAAACCTCAGAAGAATTTGTTCACATAAACAGATTGGCCCTGGAGAGTGAATTTGTTTCCTGCCA
GCTTCACCAATGGATTGATCTCATTTTTGGCTATAAACAGCAAGGACCAGAAGCTGTCCGAGCCCTCAATGTGTTCTATTACTTGACCTA
TGAAGGAGCTGTCAATCTGAATTCAATAACTGATCCTGTGTTGAGAGAGGCTGTTGAAGCTCAAATCCGAAGTTTTGGACAGACTCCTTC
TCAACTACTCATAGAGCCCCATCCTCCCAGAGGTTCTGCCATGCAAGTGAGTCCATTGATGTTCACAGACAAAGCCCAGCAGGATGTTAT
CATGGTCCTCAAGTTTCCCTCCAACTCCCCTGTTACTCACGTGGCAGCCAACACCCAGCCTGGTTTGGCAACTCCCGCTGTGATCACAGT
CACTGCTAACAGGTTATTTGCGGTGAACAAATGGCACAACCTTCCTGCTCATCAAGGTGCTGTACAAGACCAGCCATACCAGCTGCCAGT
GGAAATCGATCCTCTCATAGCCAGCAATACAGGAATGCACAGGAGGCAAATCACTGACCTTTTAGACCAAAGTATTCAAGTGCATTCCCA
GTGCTTTGTCATCACTTCAGACAACCGCTATATTCTCGTCTGTGGCTTCTGGGATAAAAGTTTCAGAGTCTATTCTACAGACACAGGAAG
ATTGATCCAAGTGGTGTTTGGCCATTGGGATGTCGTCACTTGCCTTGCTCGTTCTGAGTCATATATTGGGGGAAATTGCTACATTCTCTC
AGGGTCACGTGATGCAACTCTTTTGCTGTGGTATTGGAATGGAAAATGCAGTGGGATTGGAGATAACCCAGGCAGTGAGACTGCTGCTCC
TCGGGCCATTTTGACCGGCCATGACTATGAGGTCACATGTGCTGCGGTGTGTGCGGAGCTAGGCCTGGTGTTGAGTGGTTCACAAGAAGG
ACCATGTCTCATACATTCCATGAATGGAGACTTGTTGAGGACCTTGGAGGGTCCTGAAAACTGCCTGAAACCAAAACTCATTCAGGCTTC
AAGAGAGGGTCATTGTGTCATATTCTATGAAAACGGCCTCTTCTGTACATTCAGTGTGAATGGAAAACTCCAGGCCACGATGGAAACAGA
TGATAACATAAGAGCCATCCAGCTGAGCCGAGATGGGCAGTACCTGCTCACAGGAGGAGACAGAGGAGTGGTCGTGGTCCGGCAGGTGTC
GGACCTCAAGCAGCTCTTTGCCTATCCAGGATGTGACGCTGGAATCCGGGCCATGGCGCTGTCTTACGACCAGAGGTGCATCATTTCTGG
CATGGCTTCAGGAAGCATTGTGCTATTTTACAACGACTTTAACCGGTGGCATCATGAATACCAAACCCGCTACTGATGGTGACAGCTGTA
CATCAACTCTGCCCCTAGGATGAGCAGAAGTACCTGGAGCATCATTCTCTTCTACCACATCTGAATGTAACTTAAATTTGCTCAAAGAAG
CAAAATATTTTTTAAAGTTATTAATAATTGCTATTTTTGTAGTCTTTGCTTGACTTTTTTGGGGGGGATTAGCAAAGCAGAAAACTGGCT
GCTGGGTTCTGTAGTTTTAAAAAATCTATATTTTTAGTCATAATGAGAAGTCTATTTTCACCAATTATGGAAACATACAGTGGAGCAAGT
AAACCACTTATTCCAGCTATAATATTATGAAGAACATTTCCCATGCATCTACAAGCTTGAGAAATAGGATTTTCACAGTGGGGAAGTGGG
TTACAATATTGGAATAGGAAAATTTGATGCTGTAATTTGGGTCCTGTATTTTTCCAAACAACTGTGCTTCTTCAGCACTAATATTTCTGG
GATTTAAATAGTAATGTTTAAATTATGGTAAATGTAATTTAAAACATCTCAATTAAGTCTGTCTATCAATATTGTTCTTCAAGCATGTTT
TAGACCTAGAAAAGTATGGTTTGGGGGAGGCTATTTTATTGTGTGGTTAGCACAAGGAATCTAATTTATAGCAAGTGTGAAATAGTTACC
ATTTTTTCCTGATCTGTCATCTTCATAGCACAACAAAACGAAATGATGGAAATGCTCTTGAGCTCACAACATTTGTTTTTCTTTTAAAGT
AAATGCAAGTACCAAAGCTCACTACTGCGGTTTGCCTGTGCCTGGACAATGAGGCGGAGCCACTGTTGTTTTGTTGGGGCACCCCCTTCC
CTCCCCGGGTTTGCAAATAGAGGCTACCGGGTGCTGTATTCAGCAACACCTGTTTTACTATTTGTTATTAAACTATCATCTCCACCTTCC
TTTTGATTAGCAATTTGTACTAAGAAACGAAACAATGTTATTTGGTGGTGTATAATTCTACTTTTCTAGTAGATTACTGTGTGGAATTCT
GTGAAAAATATTTGAGAAAAGGCCTGTATTGCATAAATAAATTCTTTGTATGTTGTGAACTTTGATCTCTATTTCTCTTGCAACAGACTT
CAAGTGGTCCCTCTTTTTTTCCTACACACTCAGCTCTTCTCTAAAAGCAAGGATTTGGAATGAACAATTCAGTTTGACAGAAAAAGCTGA
ATAAAATGGCATCTGTAATTGAATTGTTGGAAATGCCTTTTTTGCTCCTAAATTTTAAACATCATTAATAAAATAATGATTCACAAAGAA

>15759_15759_4_CEP112-LRBA_CEP112_chr17_64171161_ENST00000537949_LRBA_chr4_151683001_ENST00000535741_length(amino acids)=970AA_BP=
MLSQTMKDHLVRVANEAEFILSRQRAEDIHRHAEFESLCAQYSADKREDEKMCDHLIRAAKYRDHVTATQLIQKIINILTDKHGAWGNSA
VSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHATDEDILAKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLEN
LAGPVSLSTPAQLVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFTEIRSIFSRRYLLQNTALEIFMANRVAV
MFNFPDPATVKKVVNYLPRVGVGTSFGLPQTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNY
ESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERYESWEDDQVPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSI
SRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMDDGTVVSDVELPPWAKTSEEFVHINRLALESEFVSCQLHQWIDLIFGYKQQ
GPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHPPRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHV
AANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVC
GFWDKSFRVYSTDTGRLIQVVFGHWDVVTCLARSESYIGGNCYILSGSRDATLLLWYWNGKCSGIGDNPGSETAAPRAILTGHDYEVTCA
AVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQATMETDDNIRAIQLSRDGQY

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Fusion Gene PPI Analysis for CEP112-LRBA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP112-LRBA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP112-LRBA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource