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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP170-IFI16 (FusionGDB2 ID:15799)

Fusion Gene Summary for CEP170-IFI16

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP170-IFI16
Fusion gene ID: 15799
HgeneTgene
Gene symbol

CEP170

IFI16

Gene ID

9859

3428

Gene namecentrosomal protein 170interferon gamma inducible protein 16
SynonymsFAM68A|KAB|KIAA0470IFNGIP1|PYHIN2
Cytomap

1q43

1q23.1

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDagamma-interferon-inducible protein 16IFI16 beta isoforminterferon-gamma induced protein IFI 16interferon-inducible myeloid differentiation transcriptional activator
Modification date2020031320200313
UniProtAcc

Q5SW79

Q16666

Ensembl transtripts involved in fusion geneENST00000366542, ENST00000366543, 
ENST00000366544, ENST00000468254, 
ENST00000481987, ENST00000490813, 
ENST00000295809, ENST00000340979, 
ENST00000359709, ENST00000368131, 
ENST00000368132, ENST00000430894, 
ENST00000448393, 
Fusion gene scores* DoF score12 X 9 X 10=108012 X 13 X 7=1092
# samples 1315
** MAII scorelog2(13/1080*10)=-3.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1092*10)=-2.86393845042397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP170 [Title/Abstract] AND IFI16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP170(243418342)-IFI16(158979793), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIFI16

GO:0000122

negative regulation of transcription by RNA polymerase II

12894224|24413532

TgeneIFI16

GO:0002218

activation of innate immune response

21575908

TgeneIFI16

GO:0030224

monocyte differentiation

9766636

TgeneIFI16

GO:0032731

positive regulation of interleukin-1 beta production

21575908

TgeneIFI16

GO:0042149

cellular response to glucose starvation

21573174

TgeneIFI16

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

14654789

TgeneIFI16

GO:0043392

negative regulation of DNA binding

22291595

TgeneIFI16

GO:0045071

negative regulation of viral genome replication

22291595

TgeneIFI16

GO:0045824

negative regulation of innate immune response

22046441

TgeneIFI16

GO:0045892

negative regulation of transcription, DNA-templated

9642285

TgeneIFI16

GO:0045944

positive regulation of transcription by RNA polymerase II

11146555

TgeneIFI16

GO:0051607

defense response to virus

21478870

TgeneIFI16

GO:0071479

cellular response to ionizing radiation

14654789

TgeneIFI16

GO:2000117

negative regulation of cysteine-type endopeptidase activity

22046441


check buttonFusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IFI16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8HM-01ACEP170chr1

243418342

-IFI16chr1

158979793

+
ChimerDB4PRADTCGA-YL-A8HMCEP170chr1

243418342

-IFI16chr1

158979793

+


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Fusion Gene ORF analysis for CEP170-IFI16

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000366542ENST00000295809CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366542ENST00000340979CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366542ENST00000359709CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366542ENST00000368131CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366542ENST00000368132CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366542ENST00000430894CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366543ENST00000295809CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366543ENST00000340979CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366543ENST00000359709CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366543ENST00000368131CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366543ENST00000368132CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366543ENST00000430894CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366544ENST00000295809CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366544ENST00000340979CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366544ENST00000359709CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366544ENST00000368131CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366544ENST00000368132CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-5UTRENST00000366544ENST00000430894CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-intronENST00000366542ENST00000448393CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-intronENST00000366543ENST00000448393CEP170chr1

243418342

-IFI16chr1

158979793

+
5UTR-intronENST00000366544ENST00000448393CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000468254ENST00000295809CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000468254ENST00000340979CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000468254ENST00000359709CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000468254ENST00000368131CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000468254ENST00000368132CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000468254ENST00000430894CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000481987ENST00000295809CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000481987ENST00000340979CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000481987ENST00000359709CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000481987ENST00000368131CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000481987ENST00000368132CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000481987ENST00000430894CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000490813ENST00000295809CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000490813ENST00000340979CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000490813ENST00000359709CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000490813ENST00000368131CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000490813ENST00000368132CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-5UTRENST00000490813ENST00000430894CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-intronENST00000468254ENST00000448393CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-intronENST00000481987ENST00000448393CEP170chr1

243418342

-IFI16chr1

158979793

+
intron-intronENST00000490813ENST00000448393CEP170chr1

243418342

-IFI16chr1

158979793

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CEP170-IFI16


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP170chr1243418341-IFI16chr1158979799+5.30E-070.9999995
CEP170chr1243418341-IFI16chr1158979799+5.30E-070.9999995
CEP170chr1243418341-IFI16chr1158979799+5.30E-070.9999995
CEP170chr1243418341-IFI16chr1158979799+5.30E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CEP170-IFI16


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:243418342/:158979793)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP170

Q5SW79

IFI16

Q16666

FUNCTION: Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.FUNCTION: Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein. May be involved in TP53-mediated transcriptional activation by enhancing TP53 sequence-specific DNA binding and modulating TP53 phosphorylation status. Seems to be involved in energy-level-dependent activation of the ATM/ AMPK/TP53 pathway coupled to regulation of autophagy. May be involved in regulation of TP53-mediated cell death also involving BRCA1. May be involved in the senescence of prostate epithelial cells. Involved in innate immune response by recognizing viral dsDNA in the cytosol and probably in the nucleus. After binding to viral DNA in the cytoplasm recruits TMEM173/STING and mediates the induction of IFN-beta. Has anti-inflammatory activity and inhibits the activation of the AIM2 inflammasome, probably via association with AIM2. Proposed to bind viral DNA in the nucleus, such as of Kaposi's sarcoma-associated herpesvirus, and to induce the formation of nuclear caspase-1-activating inflammasome formation via association with PYCARD. Inhibits replication of herpesviruses such as human cytomegalovirus (HCMV) probably by interfering with promoter recruitment of members of the Sp1 family of transcription factors. Necessary to activate the IRF3 signaling cascade during human herpes simplex virus 1 (HHV-1) infection and promotes the assembly of heterochromatin on herpesviral DNA and inhibition of viral immediate-early gene expression and replication. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269|PubMed:11146555, ECO:0000269|PubMed:12894224, ECO:0000269|PubMed:14654789, ECO:0000269|PubMed:20890285, ECO:0000269|PubMed:21573174, ECO:0000269|PubMed:21575908, ECO:0000269|PubMed:22046441, ECO:0000269|PubMed:22291595, ECO:0000269|PubMed:23027953, ECO:0000269|PubMed:24198334, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:9642285}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CEP170-IFI16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CEP170-IFI16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP170-IFI16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP170-IFI16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource