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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP170-RAD51B (FusionGDB2 ID:15803)

Fusion Gene Summary for CEP170-RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP170-RAD51B
Fusion gene ID: 15803
HgeneTgene
Gene symbol

CEP170

RAD51B

Gene ID

9859

5890

Gene namecentrosomal protein 170RAD51 paralog B
SynonymsFAM68A|KAB|KIAA0470R51H2|RAD51L1|REC2
Cytomap

1q43

14q24.1

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDaDNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2020031320200313
UniProtAcc

Q5SW79

O15315

Ensembl transtripts involved in fusion geneENST00000366542, ENST00000366543, 
ENST00000366544, ENST00000468254, 
ENST00000481987, ENST00000490813, 
ENST00000469165, ENST00000390683, 
ENST00000471583, ENST00000487270, 
ENST00000487861, ENST00000488612, 
Fusion gene scores* DoF score12 X 9 X 10=108041 X 23 X 12=11316
# samples 1356
** MAII scorelog2(13/1080*10)=-3.05444778402238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(56/11316*10)=-4.33679344445129
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP170 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (pmid: 29617664)
Most frequent breakpointCEP170(243349080)-RAD51B(68758600), # samples:12
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A203CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4ESCATCGA-LN-A5U5CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4ESCATCGA-LN-A8HZCEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4ESCATCGA-VR-A8EPCEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4ESCATCGA-Z6-A8JDCEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LGGTCGA-DB-5273CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LGGTCGA-DU-6399CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LGGTCGA-DU-A7TICEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LGGTCGA-FG-A711CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LGGTCGA-HT-7485CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LGGTCGA-S9-A6U6CEP170chr1

243349080

-RAD51Bchr14

68758600

+
ChimerDB4LUSCTCGA-85-6798CEP170chr1

243349080

-RAD51Bchr14

68758600

+


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Fusion Gene ORF analysis for CEP170-RAD51B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000366542ENST00000469165CEP170chr1

243349080

-RAD51Bchr14

68758600

+
In-frameENST00000366542ENST00000390683CEP170chr1

243349080

-RAD51Bchr14

68758600

+
In-frameENST00000366542ENST00000471583CEP170chr1

243349080

-RAD51Bchr14

68758600

+
In-frameENST00000366542ENST00000487270CEP170chr1

243349080

-RAD51Bchr14

68758600

+
In-frameENST00000366542ENST00000487861CEP170chr1

243349080

-RAD51Bchr14

68758600

+
In-frameENST00000366542ENST00000488612CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366543ENST00000390683CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366543ENST00000471583CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366543ENST00000487270CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366543ENST00000487861CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366543ENST00000488612CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366544ENST00000390683CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366544ENST00000471583CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366544ENST00000487270CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366544ENST00000487861CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000366544ENST00000488612CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000468254ENST00000390683CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000468254ENST00000471583CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000468254ENST00000487270CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000468254ENST00000487861CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000468254ENST00000488612CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000481987ENST00000390683CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000481987ENST00000471583CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000481987ENST00000487270CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000481987ENST00000487861CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000481987ENST00000488612CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000490813ENST00000390683CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000490813ENST00000471583CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000490813ENST00000487270CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000490813ENST00000487861CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3CDSENST00000490813ENST00000488612CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3UTRENST00000366543ENST00000469165CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3UTRENST00000366544ENST00000469165CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3UTRENST00000468254ENST00000469165CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3UTRENST00000481987ENST00000469165CEP170chr1

243349080

-RAD51Bchr14

68758600

+
intron-3UTRENST00000490813ENST00000469165CEP170chr1

243349080

-RAD51Bchr14

68758600

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000366542CEP170chr1243349080-ENST00000487861RAD51Bchr1468758600+24581618522139695
ENST00000366542CEP170chr1243349080-ENST00000471583RAD51Bchr1468758600+23501618521914620
ENST00000366542CEP170chr1243349080-ENST00000487270RAD51Bchr1468758600+34101618522016654
ENST00000366542CEP170chr1243349080-ENST00000488612RAD51Bchr1468758600+23851618521962636
ENST00000366542CEP170chr1243349080-ENST00000390683RAD51Bchr1468758600+19631618521962637

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000366542ENST00000487861CEP170chr1243349080-RAD51Bchr1468758600+0.0051573990.9948426
ENST00000366542ENST00000471583CEP170chr1243349080-RAD51Bchr1468758600+0.0025883720.99741167
ENST00000366542ENST00000487270CEP170chr1243349080-RAD51Bchr1468758600+0.0018692610.99813074
ENST00000366542ENST00000488612CEP170chr1243349080-RAD51Bchr1468758600+0.0034892160.9965108
ENST00000366542ENST00000390683CEP170chr1243349080-RAD51Bchr1468758600+0.0036875530.99631244

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Fusion Genomic Features for CEP170-RAD51B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP170chr1243349080-RAD51Bchr1468758600+1.58E-050.99998415
CEP170chr1243349080-RAD51Bchr1468758600+1.58E-050.99998415
CEP170chr1243349080-RAD51Bchr1468758600+1.58E-050.99998415
CEP170chr1243349080-RAD51Bchr1468758600+1.58E-050.99998415

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CEP170-RAD51B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243349080/chr14:68758600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP170

Q5SW79

RAD51B

O15315

FUNCTION: Plays a role in microtubule organization (PubMed:15616186). Required for centriole subdistal appendage assembly (PubMed:28422092). {ECO:0000269|PubMed:15616186, ECO:0000269|PubMed:28422092}.FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP170chr1:243349080chr14:68758600ENST00000366542-102023_735221585.0DomainFHA

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP170chr1:243349080chr14:68758600ENST00000366542-10201467_14955221585.0Coiled coilOntology_term=ECO:0000255
HgeneCEP170chr1:243349080chr14:68758600ENST00000366543-1191467_149501461.0Coiled coilOntology_term=ECO:0000255
HgeneCEP170chr1:243349080chr14:68758600ENST00000366544-1191467_149501487.0Coiled coilOntology_term=ECO:0000255
HgeneCEP170chr1:243349080chr14:68758600ENST00000366543-11923_7301461.0DomainFHA
HgeneCEP170chr1:243349080chr14:68758600ENST00000366544-11923_7301487.0DomainFHA
HgeneCEP170chr1:243349080chr14:68758600ENST00000366542-10201113_15845221585.0RegionNote=Targeting to centrosomes
HgeneCEP170chr1:243349080chr14:68758600ENST00000366542-1020853_15845221585.0RegionNote=Targeting to microtubules
HgeneCEP170chr1:243349080chr14:68758600ENST00000366543-1191113_158401461.0RegionNote=Targeting to centrosomes
HgeneCEP170chr1:243349080chr14:68758600ENST00000366543-119853_158401461.0RegionNote=Targeting to microtubules
HgeneCEP170chr1:243349080chr14:68758600ENST00000366544-1191113_158401487.0RegionNote=Targeting to centrosomes
HgeneCEP170chr1:243349080chr14:68758600ENST00000366544-119853_158401487.0RegionNote=Targeting to microtubules
TgeneRAD51Bchr1:243349080chr14:68758600ENST00000390683510108_115252367.0Nucleotide bindingATP
TgeneRAD51Bchr1:243349080chr14:68758600ENST00000471583611108_115252351.0Nucleotide bindingATP
TgeneRAD51Bchr1:243349080chr14:68758600ENST00000487270611108_115252385.0Nucleotide bindingATP
TgeneRAD51Bchr1:243349080chr14:68758600ENST00000488612612108_115252495.6666666666667Nucleotide bindingATP


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Fusion Gene Sequence for CEP170-RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15803_15803_1_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000390683_length(transcript)=1963nt_BP=1618nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGGGTGCGGCATAGATGCCAAGCAAGTTGAGGAACAATC
TGCAGCTGCAAATGAAGAAGTACTTTTTCCTTTCTGTAGGGAACCAAGTTATTTTGAAATCCCTACAAAAGAATTCCAGCAACCATCACA
AATAACAGAAAGCACTATTCATGAAATCCCAACAAAAGACACGCCAAGTTCCCATATAACAGGTGCAGGGCATGCTTCATTTACCATTGA
ATTTGATGACAGTACCCCAGGGAAGGTAACTATTAGAGACCATGTGACAAAGTTTACTTCTGATCAGCGCCACAAGTCCAAGAAGTCTTC
TCCTGGAACTCAAGACTTGCTGGGGATTCAAACAGGAATGATGGCACCCGAAAACAAAGTTGCTGACTGGCTAGCACAAAACAACCCTCC
TCAAATGCTATGGGAAAGAACAGAAGAGGATTCTAAAAGCATTAAAAGTGATGTTCCAGTGTACTTGAAAAGGTTGAAAGGAAATAAACA
TGATGATGGTACGCAAAGTGATTCAGAGAACGCTGGGGCTCACAGGCGCTGTAGCAAACGTGCAACTCTTGAGGAACACTTAAGACGCCA
CCATTCAGAACACAAAAAGCTACAGAAGGTCCAGGCTACTGAAAAGCATCAAGACCAAGCTGTTACTAGCTCTGCGCATCACAGAGGGGG
GCATGGTGTTCCACATGGGAAATTGTTAAAACAGAAATCAGAGGAGCCATCGGTGTCAATACCCTTCCTACAAACTGCATTATTAAGAAG
TTCAGGGAGTCTTGGGCACAGACCAAGCCAGGAGATGGATAAAATGTTAAAAAATCAAGCAACTTCTGCTACTTCTGAAAAGGATAATGA
TGATGACCAAAGTGACAAGGGTACTTATACCATTGAGTTAGAGAATCCCAACAGTGAGGAAGTGGAAGCAAGAAAAATGATTGACAAGGT
TATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTC
TGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCT
TGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGT

>15803_15803_1_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=637AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNR

--------------------------------------------------------------
>15803_15803_2_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000471583_length(transcript)=2350nt_BP=1618nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGGGTGCGGCATAGATGCCAAGCAAGTTGAGGAACAATC
TGCAGCTGCAAATGAAGAAGTACTTTTTCCTTTCTGTAGGGAACCAAGTTATTTTGAAATCCCTACAAAAGAATTCCAGCAACCATCACA
AATAACAGAAAGCACTATTCATGAAATCCCAACAAAAGACACGCCAAGTTCCCATATAACAGGTGCAGGGCATGCTTCATTTACCATTGA
ATTTGATGACAGTACCCCAGGGAAGGTAACTATTAGAGACCATGTGACAAAGTTTACTTCTGATCAGCGCCACAAGTCCAAGAAGTCTTC
TCCTGGAACTCAAGACTTGCTGGGGATTCAAACAGGAATGATGGCACCCGAAAACAAAGTTGCTGACTGGCTAGCACAAAACAACCCTCC
TCAAATGCTATGGGAAAGAACAGAAGAGGATTCTAAAAGCATTAAAAGTGATGTTCCAGTGTACTTGAAAAGGTTGAAAGGAAATAAACA
TGATGATGGTACGCAAAGTGATTCAGAGAACGCTGGGGCTCACAGGCGCTGTAGCAAACGTGCAACTCTTGAGGAACACTTAAGACGCCA
CCATTCAGAACACAAAAAGCTACAGAAGGTCCAGGCTACTGAAAAGCATCAAGACCAAGCTGTTACTAGCTCTGCGCATCACAGAGGGGG
GCATGGTGTTCCACATGGGAAATTGTTAAAACAGAAATCAGAGGAGCCATCGGTGTCAATACCCTTCCTACAAACTGCATTATTAAGAAG
TTCAGGGAGTCTTGGGCACAGACCAAGCCAGGAGATGGATAAAATGTTAAAAAATCAAGCAACTTCTGCTACTTCTGAAAAGGATAATGA
TGATGACCAAAGTGACAAGGGTACTTATACCATTGAGTTAGAGAATCCCAACAGTGAGGAAGTGGAAGCAAGAAAAATGATTGACAAGGT
TATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTC
TGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCT
TGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGT
TCTTCAAGGCCAAGAGAAGCCATAGGGATACTGTGACCTTTGTCTAGAGTTGATGGGGGTGTGATTTGTGAAATAAAACAGGACCGTACT
GCTTGGAAGAAGGAAACGGAAGCTGACATAATGGGGATTAATTAGTTGATTGCTGTTGAGATGGTAACAGATTTGCTCCTAAACCATTGA
GCTAGCGATTTCAGACCTAGCAGGGAAGGTGAAGATGAAGAAGCCTTTGTTCAGGTCTCTAGATGTGTAGGGCTGAGGGCTTTGCCGCCA
TGGGATGTCAACAGCCATAATAATAATTTGCACTTATATAGCACCTTTCAACCAGGCACCTCAAAGCGGTTTAACCACATTAATTAATTA
AAGCCCACAATCCTCCTGGGGAGAGGAGGAGGATGACTAACAAGATTTGTAATTACAGGAGGGAACATTTCCGAATAAAGTATTGTCTAC

>15803_15803_2_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=620AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ

--------------------------------------------------------------
>15803_15803_3_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000487270_length(transcript)=3410nt_BP=1618nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGGGTGCGGCATAGATGCCAAGCAAGTTGAGGAACAATC
TGCAGCTGCAAATGAAGAAGTACTTTTTCCTTTCTGTAGGGAACCAAGTTATTTTGAAATCCCTACAAAAGAATTCCAGCAACCATCACA
AATAACAGAAAGCACTATTCATGAAATCCCAACAAAAGACACGCCAAGTTCCCATATAACAGGTGCAGGGCATGCTTCATTTACCATTGA
ATTTGATGACAGTACCCCAGGGAAGGTAACTATTAGAGACCATGTGACAAAGTTTACTTCTGATCAGCGCCACAAGTCCAAGAAGTCTTC
TCCTGGAACTCAAGACTTGCTGGGGATTCAAACAGGAATGATGGCACCCGAAAACAAAGTTGCTGACTGGCTAGCACAAAACAACCCTCC
TCAAATGCTATGGGAAAGAACAGAAGAGGATTCTAAAAGCATTAAAAGTGATGTTCCAGTGTACTTGAAAAGGTTGAAAGGAAATAAACA
TGATGATGGTACGCAAAGTGATTCAGAGAACGCTGGGGCTCACAGGCGCTGTAGCAAACGTGCAACTCTTGAGGAACACTTAAGACGCCA
CCATTCAGAACACAAAAAGCTACAGAAGGTCCAGGCTACTGAAAAGCATCAAGACCAAGCTGTTACTAGCTCTGCGCATCACAGAGGGGG
GCATGGTGTTCCACATGGGAAATTGTTAAAACAGAAATCAGAGGAGCCATCGGTGTCAATACCCTTCCTACAAACTGCATTATTAAGAAG
TTCAGGGAGTCTTGGGCACAGACCAAGCCAGGAGATGGATAAAATGTTAAAAAATCAAGCAACTTCTGCTACTTCTGAAAAGGATAATGA
TGATGACCAAAGTGACAAGGGTACTTATACCATTGAGTTAGAGAATCCCAACAGTGAGGAAGTGGAAGCAAGAAAAATGATTGACAAGGT
TATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTC
TGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCT
TGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGT
TCTTCAAGAGACAACATTTTGCTCTGTCACCCAAGCTGAACTGAACTGGGCTCCAGAAATCCTCCCACCTCAGCCTCCTGAGCAGCTAGG
ACTACAGATGTGCCACCATACCCAGCTAATTTTTTAATTTTTTGTAGAGGTGGGGTCTCATTATGTTGCCCAAGCTGATCTCAAACTCCT
GGCTTCAAGAGATCCACCCACCTCAGCCTCCCAAAGCGCTAGGATTACAAGTATGAGACTTTGCCATTCCAATGAGAATTTTGTCCTTAG
CAATCTCATCCAATGGCCACTGGAGATGTGTGTAGGGCCACAAGAATGAGAAAGGGGGCAATGGAGTGACAGGTGACCTGCTCAGGTGCC
CCTCCCCAGACCAAATGTCCCAGGCACACAGCCCATGCCCTCCACCATGGAGTACATTTTCTCCCTGGCTTGCTGCTGAGCTAAAGGACC
AGGGACGTGGAAACAGGAGGTGAACTAAGGCACCCCGCCACCCACTGTGGCAGCTTGAATTTCTTGAGGCTGAGACAAACTAGGATCCAG
TAGCCTAGATTTTGCCCCAGTTTCTCCACTGAGTATTTACTCAGTGCTCCTGAGCCGATGCCTTCCCCTCTGCCTAGATGAACCACAGCA
TTTTGGTAAATGCCTCAGCATGTTAGGAGCGCTGGAACGTTTATTCTCTTCCCTCCCAATTATCCACTCTAATGGAGCAGAACACTTACA
TGGAAAATCCTAAACATGGAAGATGATTTAAAAATGATTCACCCTGGAATACATGCTTCCAGTTGCTTCTACAGGTTTACCTTGCTAAAG
GCATTTCGCTTCCTTTGCTGTTACAATAAGCTTGCCTGCCTTGAAGAAAAGAAGACCAGGGCCAAAGGGAAATCAGTCAAGGGAGCCTGT
TTTGTCTGAAATAATGCATCCATGAACAAATGAATTGAGTATAACTGTCTTTTTACATCAGTGTTTCTGTGGAATTAAGAGAACATCCAA
GGCCACTCCTAGCTTGAGTAGATTAAATTTGTCCTTGTGTTTGGAGCAAGGGTTGTGAAGTCTGTCTGGCCCATCAAATGACCAATGGCT
TTTAAGGAAGGACTAAGTGACTTATGACCAGAACAAGGGAGCAGCCTGAGTCAGTCTCCCCAATGTCTACATTGTGTTATTTATACTAGC
AAAAAAATAGACACAACTAAATGTTCGACCATATGGTATTGGTTAAATTAACATCTATACGATGGAATACTAGATGGTCATTAAAATTAT
GTGTCAGAAGAAGGCTTAATCTCATGGGAAAGTGTTCACACCATATTATTAAAGAGAAAAAACAGATTATAAAGCAATATGCATACAATG
TAGTAGTTCTGTAAGAAAAAAGTATTATGTGCATTTTAACTGGAAAAATATGTATAAAAATGTTAACAGTGCAATCTCTGGGCAATAAGA

>15803_15803_3_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=654AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWA

--------------------------------------------------------------
>15803_15803_4_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000487861_length(transcript)=2458nt_BP=1618nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGGGTGCGGCATAGATGCCAAGCAAGTTGAGGAACAATC
TGCAGCTGCAAATGAAGAAGTACTTTTTCCTTTCTGTAGGGAACCAAGTTATTTTGAAATCCCTACAAAAGAATTCCAGCAACCATCACA
AATAACAGAAAGCACTATTCATGAAATCCCAACAAAAGACACGCCAAGTTCCCATATAACAGGTGCAGGGCATGCTTCATTTACCATTGA
ATTTGATGACAGTACCCCAGGGAAGGTAACTATTAGAGACCATGTGACAAAGTTTACTTCTGATCAGCGCCACAAGTCCAAGAAGTCTTC
TCCTGGAACTCAAGACTTGCTGGGGATTCAAACAGGAATGATGGCACCCGAAAACAAAGTTGCTGACTGGCTAGCACAAAACAACCCTCC
TCAAATGCTATGGGAAAGAACAGAAGAGGATTCTAAAAGCATTAAAAGTGATGTTCCAGTGTACTTGAAAAGGTTGAAAGGAAATAAACA
TGATGATGGTACGCAAAGTGATTCAGAGAACGCTGGGGCTCACAGGCGCTGTAGCAAACGTGCAACTCTTGAGGAACACTTAAGACGCCA
CCATTCAGAACACAAAAAGCTACAGAAGGTCCAGGCTACTGAAAAGCATCAAGACCAAGCTGTTACTAGCTCTGCGCATCACAGAGGGGG
GCATGGTGTTCCACATGGGAAATTGTTAAAACAGAAATCAGAGGAGCCATCGGTGTCAATACCCTTCCTACAAACTGCATTATTAAGAAG
TTCAGGGAGTCTTGGGCACAGACCAAGCCAGGAGATGGATAAAATGTTAAAAAATCAAGCAACTTCTGCTACTTCTGAAAAGGATAATGA
TGATGACCAAAGTGACAAGGGTACTTATACCATTGAGTTAGAGAATCCCAACAGTGAGGAAGTGGAAGCAAGAAAAATGATTGACAAGGT
TATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTC
TGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCT
TGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGT
TCTTCAAGTTGTTAGAACTGTGGCCAGAGTCAGCCCCAGGTCAGAATGCTGGTCAGCAGCAGACTCACATCCCAGCCCTACCTTCCTGAT
ACCTGATGTGGTGCTCAGAAAAACAAGGAATCCCAGGCTGTTACCCAGTGTCTCCATGTGCCCTCCACAGATGCACTCAACTGTCCTCTC
TTCTGCTCTTCCTCCTACAAACTGGGCAACTGGAATCAGAACAGAGACTTTGGATGAGCATCCAGTGTAACCCAGCCTAGTTTTTCACCA
CGACTTCCAGATCTACATTTAACATCCGACAGCAACTATAATTCTACTTTCTGAACCTCCAGGGAAGTTGCTTCCTTGTCCCTTTCAGCA
AAGGATGTCATGGTTTTACAATGTCTCCAGTGAAAAAGTTCTTCTTCTCTACATCTTCCTCCCACTCCTACAACCCTTGATCCCCACGTG
AGATCTCATTTCCTCCAGCTGGGTCTTCTGCAGAGTGATTAGAGCTTCTGCCCTCCTTGCAGCATCTCTATTGTAAAAGGATTGCTGAAG

>15803_15803_4_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=695AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECW

--------------------------------------------------------------
>15803_15803_5_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000488612_length(transcript)=2385nt_BP=1618nt
CACGGTAAGGGGATGACGTAGCTTTGCCAAAGACTTAGAAGCTAAGCAGAAAATGAGCTTAACATCCTGGTTTTTGGTGAGCAGTGGAGG
CACTCGCCACAGGCTGCCACGAGAAATGATTTTTGTTGGAAGAGATGACTGTGAGCTCATGTTGCAGTCTCGTAGTGTGGATAAGCAACA
CGCTGTCATCAACTATGATGCGTCTACGGATGAGCATTTAGTGAAGGATTTGGGCAGCCTCAATGGGACTTTTGTGAATGATGTAAGGAT
TCCGGAACAGACTTATATCACCTTGAAACTTGAAGATAAGCTGAGATTTGGATATGATACAAATCTTTTCACTGTAGTACAAGGAGAAAT
GAGGGTCCCTGAAGAAGCTCTTAAGCATGAGAAGTTTACCATTCAGCTTCAGTTGTCCCAAAAATCTTCAGAATCAGAATTATCCAAATC
TGCAAGTGCCAAAAGCATAGATTCAAAGGTAGCAGACGCTGCTACTGAAGTGCAGCACAAAACTACTGAAGCACTGAAATCCGAGGAAAA
AGCCATGGATATTTCTGCTATGCCCCGTGGTACTCCATTATATGGGCAGCCGTCATGGTGGGGGGATGATGAGGTGGATGAAAAAAGAGC
TTTCAAGACAAATGGCAAACCTGAAGAAAAAAACCATGAAGCTGGAACATCAGGGTGCGGCATAGATGCCAAGCAAGTTGAGGAACAATC
TGCAGCTGCAAATGAAGAAGTACTTTTTCCTTTCTGTAGGGAACCAAGTTATTTTGAAATCCCTACAAAAGAATTCCAGCAACCATCACA
AATAACAGAAAGCACTATTCATGAAATCCCAACAAAAGACACGCCAAGTTCCCATATAACAGGTGCAGGGCATGCTTCATTTACCATTGA
ATTTGATGACAGTACCCCAGGGAAGGTAACTATTAGAGACCATGTGACAAAGTTTACTTCTGATCAGCGCCACAAGTCCAAGAAGTCTTC
TCCTGGAACTCAAGACTTGCTGGGGATTCAAACAGGAATGATGGCACCCGAAAACAAAGTTGCTGACTGGCTAGCACAAAACAACCCTCC
TCAAATGCTATGGGAAAGAACAGAAGAGGATTCTAAAAGCATTAAAAGTGATGTTCCAGTGTACTTGAAAAGGTTGAAAGGAAATAAACA
TGATGATGGTACGCAAAGTGATTCAGAGAACGCTGGGGCTCACAGGCGCTGTAGCAAACGTGCAACTCTTGAGGAACACTTAAGACGCCA
CCATTCAGAACACAAAAAGCTACAGAAGGTCCAGGCTACTGAAAAGCATCAAGACCAAGCTGTTACTAGCTCTGCGCATCACAGAGGGGG
GCATGGTGTTCCACATGGGAAATTGTTAAAACAGAAATCAGAGGAGCCATCGGTGTCAATACCCTTCCTACAAACTGCATTATTAAGAAG
TTCAGGGAGTCTTGGGCACAGACCAAGCCAGGAGATGGATAAAATGTTAAAAAATCAAGCAACTTCTGCTACTTCTGAAAAGGATAATGA
TGATGACCAAAGTGACAAGGGTACTTATACCATTGAGTTAGAGAATCCCAACAGTGAGGAAGTGGAAGCAAGAAAAATGATTGACAAGGT
TATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTC
TGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCT
TGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGT
TCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAATCCAGAACAGACTAAAAGAAAATGAGTCCTGAGATTGCTACAGATGAGA
CCCACCCATCGGAGCCAGGCTTTGAAGGAACTGACCGCAGTGTGCATGAGGAAGTACTTCACGGTGATGACCCTCGCCACCCTCTCAGGA
AAACACAGTGACCTCTCCCCCAACATCCCCTTCCCACTCCCAGGTCCCCCGGCAAAGGCAGAAGAACCAAGCAAGCCTTTCCACCAAAGC
AGCCATGAACCCCATTCTCATCCTTTCCAAGAACTCTCTGCTATACCAGATAGGGGTTTGGGGTTCTGTTTTCCATTTTTTAAAAAAATC
ATTTCAAGACTCTTGAACAGTGTGTCGGTTTACACTATTCTATCTTCTTAAGCCACCATATCAACATATTCACTCTGCTTCCTTTCTTTT

>15803_15803_5_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=636AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEP170-RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCEP170chr1:243349080chr14:68758600ENST00000366542-10201015_1460522.01585.0CCDC61
HgeneCEP170chr1:243349080chr14:68758600ENST00000366543-1191015_146001461.0CCDC61
HgeneCEP170chr1:243349080chr14:68758600ENST00000366544-1191015_146001487.0CCDC61
TgeneRAD51Bchr1:243349080chr14:68758600ENST000003906835101_75252.0367.0RAD51C
TgeneRAD51Bchr1:243349080chr14:68758600ENST000004715836111_75252.0351.0RAD51C
TgeneRAD51Bchr1:243349080chr14:68758600ENST000004872706111_75252.0385.0RAD51C
TgeneRAD51Bchr1:243349080chr14:68758600ENST000004886126121_75252.0495.6666666666667RAD51C


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP170-RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP170-RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource