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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CEP192-TRIM27 (FusionGDB2 ID:15820)

Fusion Gene Summary for CEP192-TRIM27

Fusion gene summary

Fusion gene information	Fusion gene name: CEP192-TRIM27
	Fusion gene ID: 15820
		Hgene	Tgene
	Gene symbol	CEP192	TRIM27
	Gene ID	55125	5987
	Gene name	centrosomal protein 192	tripartite motif containing 27
	Synonyms	PPP1R62	RFP\|RNF76
	Cytomap	18p11.21	6p22.1
	Type of gene	protein-coding	protein-coding
	Description	centrosomal protein of 192 kDa192 kDa centrosomal proteincentrosomal protein 192kDacep192/SPD-2protein phosphatase 1, regulatory subunit 62	zinc finger protein RFPRFP transforming proteinRING finger protein 76RING-type E3 ubiquitin transferase TRIM27ret finger proteintripartite motif protein TRIM27tripartite motif-containing protein 27
	Modification date	20200313	20200327
	UniProtAcc	Q8TEP8	P14373
	Ensembl transtripts involved in fusion gene	ENST00000325971, ENST00000430049, ENST00000506447, ENST00000540847,	ENST00000377194, ENST00000377199, ENST00000400720, ENST00000412687, ENST00000417660, ENST00000427689, ENST00000431123, ENST00000435528, ENST00000437160, ENST00000437415, ENST00000452265, ENST00000455861, ENST00000459807, ENST00000468047, ENST00000468364, ENST00000485666, ENST00000491158, ENST00000495323, ENST00000498117,
Fusion gene scores	* DoF score	11 X 10 X 9=990	4 X 4 X 2=32
	# samples	11	4
	** MAII score	log2(11/990*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CEP192 [Title/Abstract] AND TRIM27 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CEP192(13089012)-TRIM27(28871618), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CEP192	GO:0010923	negative regulation of phosphatase activity	19389623
Tgene	TRIM27	GO:0000122	negative regulation of transcription by RNA polymerase II	10976108
Tgene	TRIM27	GO:0006469	negative regulation of protein kinase activity	22128329
Tgene	TRIM27	GO:0032897	negative regulation of viral transcription	18248090
Tgene	TRIM27	GO:0034314	Arp2/3 complex-mediated actin nucleation	23452853
Tgene	TRIM27	GO:0042147	retrograde transport, endosome to Golgi	23452853
Tgene	TRIM27	GO:0045087	innate immune response	18248090
Tgene	TRIM27	GO:0045814	negative regulation of gene expression, epigenetic	10976108
Tgene	TRIM27	GO:0051091	positive regulation of DNA-binding transcription factor activity	23077300

Fusion gene breakpoints across CEP192 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIM27 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BM145214	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+

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Fusion Gene ORF analysis for CEP192-TRIM27

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000325971	ENST00000377194	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000325971	ENST00000377199	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000430049	ENST00000377194	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000430049	ENST00000377199	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000506447	ENST00000377194	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000506447	ENST00000377199	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000540847	ENST00000377194	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-3UTR	ENST00000540847	ENST00000377199	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000400720	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000412687	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000417660	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000427689	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000431123	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000435528	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000437160	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000437415	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000452265	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000455861	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000459807	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000468047	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000468364	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000485666	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000491158	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000495323	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000325971	ENST00000498117	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000400720	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000412687	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000417660	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000427689	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000431123	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000435528	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000437160	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000437415	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000452265	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000455861	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000459807	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000468047	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000468364	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000485666	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000491158	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000495323	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000430049	ENST00000498117	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000400720	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000412687	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000417660	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000427689	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000431123	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000435528	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000437160	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000437415	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000452265	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000455861	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000459807	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000468047	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000468364	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000485666	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000491158	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000495323	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000506447	ENST00000498117	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000400720	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000412687	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000417660	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000427689	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000431123	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000435528	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000437160	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000437415	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000452265	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000455861	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000459807	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000468047	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000468364	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000485666	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000491158	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000495323	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+
intron-intron	ENST00000540847	ENST00000498117	CEP192	chr18	13089012	+	TRIM27	chr6	28871618	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CEP192-TRIM27

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP192-TRIM27

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:13089012/:28871618)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CEP192 Q8TEP8	TRIM27 P14373
FUNCTION: Required for mitotic centrosome maturation and bipolar spindle assembly (PubMed:25042804, PubMed:17980596, PubMed:18207742). Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication (PubMed:25042804, PubMed:17980596, PubMed:18207742). Centrosome-specific activating scaffold for AURKA and PLK1 (PubMed:25042804). {ECO:0000269\|PubMed:17980596, ECO:0000269\|PubMed:18207742, ECO:0000269\|PubMed:25042804}.	FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853). Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. {ECO:0000269\|PubMed:10976108, ECO:0000269\|PubMed:12807881, ECO:0000269\|PubMed:22128329, ECO:0000269\|PubMed:23452853}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CEP192-TRIM27

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CEP192-TRIM27

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CEP192-TRIM27

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CEP192-TRIM27

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source