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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CEP350-TDRD5 (FusionGDB2 ID:15858)

Fusion Gene Summary for CEP350-TDRD5

Fusion gene summary

Fusion gene information	Fusion gene name: CEP350-TDRD5
	Fusion gene ID: 15858
		Hgene	Tgene
	Gene symbol	CEP350	TDRD5
	Gene ID	9857	163589
	Gene name	centrosomal protein 350	tudor domain containing 5
	Synonyms	CAP350\|GM133	TUDOR3
	Cytomap	1q25.2	1q25.2
	Type of gene	protein-coding	protein-coding
	Description	centrosome-associated protein 350centrosomal protein 350kDa	tudor domain-containing protein 5testicular tissue protein Li 194
	Modification date	20200313	20200313
	UniProtAcc	Q5VT06	.
	Ensembl transtripts involved in fusion gene	ENST00000367607, ENST00000490141,	ENST00000294848, ENST00000444136, ENST00000367614,
Fusion gene scores	* DoF score	11 X 10 X 8=880	2 X 3 X 2=12
	# samples	13	3
	** MAII score	log2(13/880*10)=-2.75899190049621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CEP350 [Title/Abstract] AND TDRD5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CEP350(180010383)-TDRD5(179659831), # samples:3
Anticipated loss of major functional domain due to fusion event.	CEP350-TDRD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CEP350-TDRD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CEP350 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TDRD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0799-01A	CEP350	chr1	180010383	-	TDRD5	chr1	179659831	+
ChimerDB4	OV	TCGA-13-0799-01A	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
ChimerDB4	OV	TCGA-13-0799	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+

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Fusion Gene ORF analysis for CEP350-TDRD5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000367607	ENST00000294848	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
Frame-shift	ENST00000367607	ENST00000294848	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+
Frame-shift	ENST00000367607	ENST00000444136	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
Frame-shift	ENST00000367607	ENST00000444136	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+
In-frame	ENST00000367607	ENST00000367614	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
In-frame	ENST00000367607	ENST00000367614	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+
intron-3CDS	ENST00000490141	ENST00000294848	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
intron-3CDS	ENST00000490141	ENST00000294848	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+
intron-3CDS	ENST00000490141	ENST00000367614	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
intron-3CDS	ENST00000490141	ENST00000367614	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+
intron-3CDS	ENST00000490141	ENST00000444136	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+
intron-3CDS	ENST00000490141	ENST00000444136	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000367607

CEP350

chr1

180010383

ENST00000367614

TDRD5

chr1

179659831

5214

4639

418

4662

1414

ENST00000367607

CEP350

chr1

180010383

ENST00000367614

TDRD5

chr1

179659830

5214

4639

418

4662

1414

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367607	ENST00000367614	CEP350	chr1	180010383	+	TDRD5	chr1	179659831	+	0.000978296	0.99902165
ENST00000367607	ENST00000367614	CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+	0.000978296	0.99902165

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Fusion Genomic Features for CEP350-TDRD5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+	0.81182593	0.18817407
CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+	0.81182593	0.18817407
CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+	0.81182593	0.18817407
CEP350	chr1	180010383	+	TDRD5	chr1	179659830	+	0.81182593	0.18817407

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP350-TDRD5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:180010383/chr1:179659831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CEP350 Q5VT06	.
FUNCTION: Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ (PubMed:19052644). Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network (PubMed:16314388, PubMed:17878239, PubMed:28659385). Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity (PubMed:15615782). Required for ciliation (PubMed:28659385). {ECO:0000269\|PubMed:15615782, ECO:0000269\|PubMed:16314388, ECO:0000269\|PubMed:17878239, ECO:0000269\|PubMed:19052644, ECO:0000269\|PubMed:28659385}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

598_645

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

598_645

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

1112_1281

1407

3118.0

Compositional bias

Note=Ser-rich

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

1112_1281

1407

3118.0

Compositional bias

Note=Ser-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

1369_1411

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

1707_1800

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

1856_1899

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

2051_2110

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

2719_2752

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

1369_1411

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

1707_1800

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

1856_1899

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

2051_2110

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

2719_2752

1407

3118.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

1502_1556

1407

3118.0

Compositional bias

Note=Ser-rich

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

1502_1556

1407

3118.0

Compositional bias

Note=Ser-rich

Hgene

CEP350

chr1:180010383

chr1:179659830

ENST00000367607

2517_2559

1407

3118.0

Domain

CAP-Gly

Hgene

CEP350

chr1:180010383

chr1:179659831

ENST00000367607

2517_2559

1407

3118.0

Domain

CAP-Gly

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000294848

127_202

899

982.0

Domain

HTH OST-type 2

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000294848

295_369

899

982.0

Domain

HTH OST-type 3

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000294848

525_584

899

982.0

Domain

Tudor

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000294848

7_80

899

982.0

Domain

HTH OST-type 1

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000367614

127_202

899

982.0

Domain

HTH OST-type 2

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000367614

295_369

899

982.0

Domain

HTH OST-type 3

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000367614

525_584

899

982.0

Domain

Tudor

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000367614

7_80

899

982.0

Domain

HTH OST-type 1

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000444136

127_202

953

1036.0

Domain

HTH OST-type 2

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000444136

295_369

953

1036.0

Domain

HTH OST-type 3

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000444136

525_584

953

1036.0

Domain

Tudor

Tgene

TDRD5

chr1:180010383

chr1:179659830

ENST00000444136

7_80

953

1036.0

Domain

HTH OST-type 1

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000294848

127_202

899

982.0

Domain

HTH OST-type 2

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000294848

295_369

899

982.0

Domain

HTH OST-type 3

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000294848

525_584

899

982.0

Domain

Tudor

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000294848

7_80

899

982.0

Domain

HTH OST-type 1

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000367614

127_202

899

982.0

Domain

HTH OST-type 2

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000367614

295_369

899

982.0

Domain

HTH OST-type 3

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000367614

525_584

899

982.0

Domain

Tudor

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000367614

7_80

899

982.0

Domain

HTH OST-type 1

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000444136

127_202

953

1036.0

Domain

HTH OST-type 2

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000444136

295_369

953

1036.0

Domain

HTH OST-type 3

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000444136

525_584

953

1036.0

Domain

Tudor

Tgene

TDRD5

chr1:180010383

chr1:179659831

ENST00000444136

7_80

953

1036.0

Domain

HTH OST-type 1

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Fusion Gene Sequence for CEP350-TDRD5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15858_15858_1_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659830_ENST00000367614_length(transcript)=5214nt_BP=4639nt
GCCCGACTGCTCCCGCCCTGCCTCGCGCCGCCGCCACAGCCGCTGCCGCTGGCGCCGCTCCTCCTCCGTGTCAGTTGTTGGGCTGTAATG
GCGACTGGGCCGCCCCTGACGAAGTGACTCCCGGGCCGGGGAGCGGGGCCAGACCTGCGCCAGAGAGAACTGCAGGGAGCCGCAGCTCGG
GGGGTGGCTTGCCCTGAGGGAGGGGAGGCAGCCTTTCCGCCTTGTCTTCCTTCCCAGCGGACCGGCGGATCCCCGGAGCCGGTGCGAGGA
GGGCACCCGGTGCGTCCCCGGAGCGGGGAGGCCAGGCCGGGCAGCCCTGGGGCCGGTCGGGGCGGCGTCACTGCACCCTCCGCCAGGCTC
CGCGGGATGCACCGTGGTAGCCGAGGGCGGAGGCGACACTCTCAGGTAAATTGGCAGGATGAGGAGCAGCAAATCAAAAGAGGTGCCTTT
ACCAAATCCAAGGAACTCTCAAAGCAAGGATACTGTTCAAGCAGATATAACCACATCGTGGGATGCACTTTCTCAAACCAAGGCTGCTCT
GAGACACATTGAAAATAAATTAGAAGTAGCCCCTACAAGTACAGCTGTGTGTGATTCTGTCATGGATACCAAGAAGTCTTCTACAAGTGC
TACTCGAAAAATAAGTAGAAAAGATGGTAGATACCTGGATGATTCTTGGGTTAATGCTCCAATCTCCAAATCCACTAAATCACGAAAAGA
GAAATCTCGTAGTCCTCTCAGGGCCACCACCCTGGAGAGTAATGTGAAGAAAAATAATCGTGTGGAATTTCGTGAACCTTTGGTTTCTTA
TAGGGAAATCCATGGTGCACCTTCCAATTTCAGTTCCAGCCATCTGGAATCAAAGCACGTATACTGTGTAGATGTTAATGAAGAAAAGAC
TGAGAGCGGTAACTGGATGATAGGCAGTCGAGAAGAACGGAATATACGGAGCTGTGATTTTGAGAGCTCCCAATCATCTGTCATCAATGA
TACAGTTGTTAGGTTTTTAAATGATCGACCAGCAATTGATGCATTGCAAAATTCTGAATGTTTGATTAGGATGGGAGCTTCTATGAGAAC
TGAGGAAGAAATGCCTAACAGAACAAAAGGAAGTGAGAATAATTTGAAGCTTTCTGTGAATAACATGGCCCATGATACTGATCCAAAAGC
GTTACGACTAACTGACTCTTCTCCATCCTCTACTAGTACTTCTAATTCCCAAAGATTAGATATTCTAAAGCGGCGACAACATGATGTCAA
ACTGGAAAAACTTAAGGAACGGATTAGAAAACAGTGGGAACACTCAGAAGAAACAAATGGCCGGGGCCAGAAGCTGGGTCATATTGACCA
TCCAGTAATGGTTGTTAATGTTGATAACTCAGTAACAGCAAAAGTCAGAAAAGTGGCAACAGCACCACCTGCTCCAGCATATAAAGGTTT
CAACCCTTCAGAGACCAAGATTCGAACACCTGATGGGAAAGTGTGGCAGGAGGCTGAGTTTCAAAACATGAGTAGAGAACTGTATCGAGA
TTTAGCACTTCACTTTGCAGATGATATTTCTATAAAGGAGAAACCTGCTGAAAAAAGTAAAGAGAAGAAAGTAGTCAAGCCAGTACGAAA
AGTCCAAAAAGTAGCACAGTTATCAAGTACAGAATGCAGAACAGGTAGTAGTCATCTTATAAGTACATCTTCTTGGCGAGATGGACAAAA
ATTAGTAAAGAAGATTCTGGGACCTGCTCCCAGAATGGAGCCAAAAGAGCAAAGAACAGCATCAAGTGACAGAGGTGGAAGAGAAAGAAC
TGCTAAATCTGGGGGTCACATTGGAAGAGCAGAATCTGATCCCAGGTTGGACGTTTTACATAGACATCTTCAAAGAAACTCAGAACGTTC
GAGAAGTAAATCTCGGTCTGAAAATAATATAAAGAAACTAGCTTCATCTCTTCCAGATAATAAGCAGGAGGAAAATACTGCCTTAAATAA
GGACTTTTTACCTATTGAAATTCGTGGCATTCTTGATGACCTACAGCTGGATTCTACAGCTCACACTGCAAAGCAAGATACTGTAGAGTT
ACAGAACCAGAAGTCATCAGCACCAGTACATGCTCCTAGGAGTCACAGCCCAGTAAAAAGAAAACCTGACAAAATAACAGCTAATGAAGA
TCCCCCTGTTATTTCCAAAAGGCGCCACTATGACACAGATGAGGTACGACAGTACATTGTTAGGCAGCAGGAGGAAAGGAAGAGAAAGCA
AAATGAAGAGAAGAAGGCTCAAAAGGAGGCTACAGAACAGAAAAACAAACGATTACAAGAGCTCTACCGGAAGCAGAAGGAAGCCTTTAC
TAAAGTAAAAAATGTCCCTCCTTCTGAGCCATCAGCAACTAGGCGACTACAGGAAACTTACTCCAAATTGCTACTAGAAAAGACCTTGCT
TGAAGAGCCATCTCATCAACATGTTACGCAGGAAACACAGGCCAAACCAGGGTATCAGCCATCTGGAGAATCTGACAAAGAAAACAAAGT
ACAGGAACGTCCCCCAAGTGCATCTTCCAGTAGTGACATGTCTCTCTCAGAACCTCCACAGCCTCTTGCAAGAAAAGACTTGATGGAATC
TACATGGATGCAGCCTGAAAGATTGAGCCCACAAGTTCACCATTCTCAACCACAGCCTTTTGCTGGAACAGCTGGAAGTTTACTCTCCCA
TCTCTTGAGTTTAGAGCATGTAGGAATTTTGCATAAGGATTTTGAATCTATTTTACCAACCAGGAAGAATCATAATATGGCTTCAAGGCC
ATTAACTTTTACACCTCAACCATATGTGACCTCACCAGCTGCTTATACAGATGCCTTGTTAAAACCTAGTGCCAGCCAATATAAGAGTAA
ACTGGATCGTATTGAAGCCTTGAAAGCAACAGCTGCTTCTTTGTCCAGCAGAATTGAAAGTGAAGCCAAGAAATTAGCTGGGGCCAGCAT
TAACTATGGGTCAGCATGGAACACTGAGTATGATGTGCAGCAGGCACCTCAAGAAGATGGACCTTGGACCAAGGCTGTAACTCCACCTGT
GAAAGATGATAATGAAGATGTTTTCTCTGCCAGAATTCAGAAGATGCTGGGAAGCTGTGTATCTCATGCAACTTTTGATGATGATCTTCC
TGGTGTAGGCAATCTTAGTGAATTTAAAAAGCTTCCTGAGATGATAAGACCACAGAGTGCCATATCAAGCTTTAGAGTGAGATCCCCTGG
TCCCAAACCAGAAGGGCTACTGGCACAGTTATGTAAAAGGCAGACTGACTCTTCTAGCTCTGATATGCAAGCCTGTTCTCAAGACAAAGC
CAAAATATCTCTTGGTTCCAGCATAGATTCAGTCAGTGAAGGGCCTCTTCTTAGTGAGGGGAGTCTCTCTGAAGAAGAGGGAGACCAGGA
TGGACAGCCCCTTTTGAAAGTAGCAGAAATTTTAAAAGAAAAGGAATTTTGTCCTGGAGAAAGAAATAGTTATGAACCCATCAAAGAGTT
TCAGAAAGAAGCTGAAAAATTCTTGCCACTTTTTGGGCACATAGGTGGTACACAAAGCAAAGGACCATGGGAAGAATTGGCAAAGGGAAG
TCCACATAGCGTCATTAATATTTTTACAAAATCCTATCAGTTATATGGAAAAGGGTTTGAAGACAAGTTGGACAGAGGAACATCAACATC
ACGGCCTTTGAATGCCACCGCAACTCCTCTAAGTGGTGTTTCATATGAAGATGATTTTGTCTCCTCTCCAGGGACTGGGACTTCGACAGA
AAAAAAATCAACTCTTGAACCTCATAGCACTTTAAGCCCTCAGGAGGACCATTCTAACAGAAAGTCTGCCTATGATCCTTCCTCTGTGGA
TGTTACCTCCCAGCATTCATCAGGAGCCCAGTCTGCTGCATCGTCTCGTTCATCTACTTCTTCTAAAGGAAAGAAAGGAAAAAAGGAAAA
GACAGAATGGTTGGATTCATTCACTGGAAATGTTCAGAACTCACTTCTTGATGAGGAAAAAGCAGAACGTGGCTCCCATCAAGGAAAGAA
ATCTGGGACCAGCAGCAAACTTTCTGTTAAAGATTTTGAGCAGACTCTTGATACAGATAGCACTTTGGAGGATCTTTCTGGACATTCTGT
GAGTGTCTCATCAGATAAGGGAAGATCTCAGAAAACTCCAACTTCTCCCCTGTCACCAAGTTCCCAGAAATCATTGCAGTTTGACGTTGC
AGGAACTTCTTCAGAAAGATCTAAGTCGTCAGTAATGCCTCCAACTATAACAGGATTTAAGCCTAATGCACCTCTCACTGATCTGAACCC
GGCAGCCAGCAGAACAACGACAGAGAACATGGCTCCAATACCAGGTTCTAAGCGCTTTTCTCCTGCTGGCCTCCATCATCGTATGGCAGC
AGAACTCAGTTATCTGAACGCCATTGAGGAGTCGGTGCGCCAACTGTCAGATGTAGAAAGAGTTAGAGGCATTTCACTTGCTCAGCAGGA
GAGTGTGTCTCTAGCTCAGATAATAAAGGCACAACAGCAACGCCATGAAAGAGACTTGGCCCTCTTGAAACTAAAGGCTGAACAAGAGGC
TCTGGAGAGTCAGAGACAATTAGAAGAAACCCGAAACAAAGCAGCTCAGTGGAAAGCTCACCAGAGATCCTAAAGAATGAAGATTTTTCT
AGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGATTTTGTCTTATGAGTGCCAGATTTCT
CAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTACATCCAGGAGCCTCCTACACTGGTAC
CCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCGCTTAGGCTTTGATGAACTCCCAGGC
CAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACTATATGTTAGCTTTATTATGCTAACA
GTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATTCTGTGTCATTTTGTTCACCTTTGTT

>15858_15858_1_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659830_ENST00000367614_length(amino acids)=1414AA_BP=
MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNA
PISKSTKSRKEKSRSPLRATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD
FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSVNNMAHDTDPKALRLTDSSPSSTSTSNSQRL
DILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE
FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRT
ASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST
AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQ
ELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP
QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILPTRKNHNMASRPLTFTPQPYVTSPAAYTDAL
LKPSASQYKSKLDRIEALKATAASLSSRIESEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC
VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSSSDMQACSQDKAKISLGSSIDSVSEGPLLSE
GSLSEEEGDQDGQPLLKVAEILKEKEFCPGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF
EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSST
SSKGKKGKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP
SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVE

--------------------------------------------------------------
>15858_15858_2_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659831_ENST00000367614_length(transcript)=5214nt_BP=4639nt
GCCCGACTGCTCCCGCCCTGCCTCGCGCCGCCGCCACAGCCGCTGCCGCTGGCGCCGCTCCTCCTCCGTGTCAGTTGTTGGGCTGTAATG
GCGACTGGGCCGCCCCTGACGAAGTGACTCCCGGGCCGGGGAGCGGGGCCAGACCTGCGCCAGAGAGAACTGCAGGGAGCCGCAGCTCGG
GGGGTGGCTTGCCCTGAGGGAGGGGAGGCAGCCTTTCCGCCTTGTCTTCCTTCCCAGCGGACCGGCGGATCCCCGGAGCCGGTGCGAGGA
GGGCACCCGGTGCGTCCCCGGAGCGGGGAGGCCAGGCCGGGCAGCCCTGGGGCCGGTCGGGGCGGCGTCACTGCACCCTCCGCCAGGCTC
CGCGGGATGCACCGTGGTAGCCGAGGGCGGAGGCGACACTCTCAGGTAAATTGGCAGGATGAGGAGCAGCAAATCAAAAGAGGTGCCTTT
ACCAAATCCAAGGAACTCTCAAAGCAAGGATACTGTTCAAGCAGATATAACCACATCGTGGGATGCACTTTCTCAAACCAAGGCTGCTCT
GAGACACATTGAAAATAAATTAGAAGTAGCCCCTACAAGTACAGCTGTGTGTGATTCTGTCATGGATACCAAGAAGTCTTCTACAAGTGC
TACTCGAAAAATAAGTAGAAAAGATGGTAGATACCTGGATGATTCTTGGGTTAATGCTCCAATCTCCAAATCCACTAAATCACGAAAAGA
GAAATCTCGTAGTCCTCTCAGGGCCACCACCCTGGAGAGTAATGTGAAGAAAAATAATCGTGTGGAATTTCGTGAACCTTTGGTTTCTTA
TAGGGAAATCCATGGTGCACCTTCCAATTTCAGTTCCAGCCATCTGGAATCAAAGCACGTATACTGTGTAGATGTTAATGAAGAAAAGAC
TGAGAGCGGTAACTGGATGATAGGCAGTCGAGAAGAACGGAATATACGGAGCTGTGATTTTGAGAGCTCCCAATCATCTGTCATCAATGA
TACAGTTGTTAGGTTTTTAAATGATCGACCAGCAATTGATGCATTGCAAAATTCTGAATGTTTGATTAGGATGGGAGCTTCTATGAGAAC
TGAGGAAGAAATGCCTAACAGAACAAAAGGAAGTGAGAATAATTTGAAGCTTTCTGTGAATAACATGGCCCATGATACTGATCCAAAAGC
GTTACGACTAACTGACTCTTCTCCATCCTCTACTAGTACTTCTAATTCCCAAAGATTAGATATTCTAAAGCGGCGACAACATGATGTCAA
ACTGGAAAAACTTAAGGAACGGATTAGAAAACAGTGGGAACACTCAGAAGAAACAAATGGCCGGGGCCAGAAGCTGGGTCATATTGACCA
TCCAGTAATGGTTGTTAATGTTGATAACTCAGTAACAGCAAAAGTCAGAAAAGTGGCAACAGCACCACCTGCTCCAGCATATAAAGGTTT
CAACCCTTCAGAGACCAAGATTCGAACACCTGATGGGAAAGTGTGGCAGGAGGCTGAGTTTCAAAACATGAGTAGAGAACTGTATCGAGA
TTTAGCACTTCACTTTGCAGATGATATTTCTATAAAGGAGAAACCTGCTGAAAAAAGTAAAGAGAAGAAAGTAGTCAAGCCAGTACGAAA
AGTCCAAAAAGTAGCACAGTTATCAAGTACAGAATGCAGAACAGGTAGTAGTCATCTTATAAGTACATCTTCTTGGCGAGATGGACAAAA
ATTAGTAAAGAAGATTCTGGGACCTGCTCCCAGAATGGAGCCAAAAGAGCAAAGAACAGCATCAAGTGACAGAGGTGGAAGAGAAAGAAC
TGCTAAATCTGGGGGTCACATTGGAAGAGCAGAATCTGATCCCAGGTTGGACGTTTTACATAGACATCTTCAAAGAAACTCAGAACGTTC
GAGAAGTAAATCTCGGTCTGAAAATAATATAAAGAAACTAGCTTCATCTCTTCCAGATAATAAGCAGGAGGAAAATACTGCCTTAAATAA
GGACTTTTTACCTATTGAAATTCGTGGCATTCTTGATGACCTACAGCTGGATTCTACAGCTCACACTGCAAAGCAAGATACTGTAGAGTT
ACAGAACCAGAAGTCATCAGCACCAGTACATGCTCCTAGGAGTCACAGCCCAGTAAAAAGAAAACCTGACAAAATAACAGCTAATGAAGA
TCCCCCTGTTATTTCCAAAAGGCGCCACTATGACACAGATGAGGTACGACAGTACATTGTTAGGCAGCAGGAGGAAAGGAAGAGAAAGCA
AAATGAAGAGAAGAAGGCTCAAAAGGAGGCTACAGAACAGAAAAACAAACGATTACAAGAGCTCTACCGGAAGCAGAAGGAAGCCTTTAC
TAAAGTAAAAAATGTCCCTCCTTCTGAGCCATCAGCAACTAGGCGACTACAGGAAACTTACTCCAAATTGCTACTAGAAAAGACCTTGCT
TGAAGAGCCATCTCATCAACATGTTACGCAGGAAACACAGGCCAAACCAGGGTATCAGCCATCTGGAGAATCTGACAAAGAAAACAAAGT
ACAGGAACGTCCCCCAAGTGCATCTTCCAGTAGTGACATGTCTCTCTCAGAACCTCCACAGCCTCTTGCAAGAAAAGACTTGATGGAATC
TACATGGATGCAGCCTGAAAGATTGAGCCCACAAGTTCACCATTCTCAACCACAGCCTTTTGCTGGAACAGCTGGAAGTTTACTCTCCCA
TCTCTTGAGTTTAGAGCATGTAGGAATTTTGCATAAGGATTTTGAATCTATTTTACCAACCAGGAAGAATCATAATATGGCTTCAAGGCC
ATTAACTTTTACACCTCAACCATATGTGACCTCACCAGCTGCTTATACAGATGCCTTGTTAAAACCTAGTGCCAGCCAATATAAGAGTAA
ACTGGATCGTATTGAAGCCTTGAAAGCAACAGCTGCTTCTTTGTCCAGCAGAATTGAAAGTGAAGCCAAGAAATTAGCTGGGGCCAGCAT
TAACTATGGGTCAGCATGGAACACTGAGTATGATGTGCAGCAGGCACCTCAAGAAGATGGACCTTGGACCAAGGCTGTAACTCCACCTGT
GAAAGATGATAATGAAGATGTTTTCTCTGCCAGAATTCAGAAGATGCTGGGAAGCTGTGTATCTCATGCAACTTTTGATGATGATCTTCC
TGGTGTAGGCAATCTTAGTGAATTTAAAAAGCTTCCTGAGATGATAAGACCACAGAGTGCCATATCAAGCTTTAGAGTGAGATCCCCTGG
TCCCAAACCAGAAGGGCTACTGGCACAGTTATGTAAAAGGCAGACTGACTCTTCTAGCTCTGATATGCAAGCCTGTTCTCAAGACAAAGC
CAAAATATCTCTTGGTTCCAGCATAGATTCAGTCAGTGAAGGGCCTCTTCTTAGTGAGGGGAGTCTCTCTGAAGAAGAGGGAGACCAGGA
TGGACAGCCCCTTTTGAAAGTAGCAGAAATTTTAAAAGAAAAGGAATTTTGTCCTGGAGAAAGAAATAGTTATGAACCCATCAAAGAGTT
TCAGAAAGAAGCTGAAAAATTCTTGCCACTTTTTGGGCACATAGGTGGTACACAAAGCAAAGGACCATGGGAAGAATTGGCAAAGGGAAG
TCCACATAGCGTCATTAATATTTTTACAAAATCCTATCAGTTATATGGAAAAGGGTTTGAAGACAAGTTGGACAGAGGAACATCAACATC
ACGGCCTTTGAATGCCACCGCAACTCCTCTAAGTGGTGTTTCATATGAAGATGATTTTGTCTCCTCTCCAGGGACTGGGACTTCGACAGA
AAAAAAATCAACTCTTGAACCTCATAGCACTTTAAGCCCTCAGGAGGACCATTCTAACAGAAAGTCTGCCTATGATCCTTCCTCTGTGGA
TGTTACCTCCCAGCATTCATCAGGAGCCCAGTCTGCTGCATCGTCTCGTTCATCTACTTCTTCTAAAGGAAAGAAAGGAAAAAAGGAAAA
GACAGAATGGTTGGATTCATTCACTGGAAATGTTCAGAACTCACTTCTTGATGAGGAAAAAGCAGAACGTGGCTCCCATCAAGGAAAGAA
ATCTGGGACCAGCAGCAAACTTTCTGTTAAAGATTTTGAGCAGACTCTTGATACAGATAGCACTTTGGAGGATCTTTCTGGACATTCTGT
GAGTGTCTCATCAGATAAGGGAAGATCTCAGAAAACTCCAACTTCTCCCCTGTCACCAAGTTCCCAGAAATCATTGCAGTTTGACGTTGC
AGGAACTTCTTCAGAAAGATCTAAGTCGTCAGTAATGCCTCCAACTATAACAGGATTTAAGCCTAATGCACCTCTCACTGATCTGAACCC
GGCAGCCAGCAGAACAACGACAGAGAACATGGCTCCAATACCAGGTTCTAAGCGCTTTTCTCCTGCTGGCCTCCATCATCGTATGGCAGC
AGAACTCAGTTATCTGAACGCCATTGAGGAGTCGGTGCGCCAACTGTCAGATGTAGAAAGAGTTAGAGGCATTTCACTTGCTCAGCAGGA
GAGTGTGTCTCTAGCTCAGATAATAAAGGCACAACAGCAACGCCATGAAAGAGACTTGGCCCTCTTGAAACTAAAGGCTGAACAAGAGGC
TCTGGAGAGTCAGAGACAATTAGAAGAAACCCGAAACAAAGCAGCTCAGTGGAAAGCTCACCAGAGATCCTAAAGAATGAAGATTTTTCT
AGCAGCCGTGCTATTACATTGTACAAAGACAAGCGTCAAGAATCTGTAGACCAGCTGTCTTTGATTTTGTCTTATGAGTGCCAGATTTCT
CAGAAGCTCTACATTCCTCGAAGTACAGCCACTGCTGCCTTAGGTGCTGCCGCACGGTTAGCTACATCCAGGAGCCTCCTACACTGGTAC
CCCAGTGTGAAAAGGATGGAAGCATGAGGGAGGGAGGGAGGAGGGAGAAAAACAGAATCCAGCCGCTTAGGCTTTGATGAACTCCCAGGC
CAAAATGAGGAGTTATTGAAGCAAAATAGTATCTTGATCATTGATACTTTTGTCTTTCTGTGACTATATGTTAGCTTTATTATGCTAACA
GTCTACTTTGATGTGTAAGTAAGTATTGATATTTACTGTTAATCTTGATTTTTCTTGATTTTATTCTGTGTCATTTTGTTCACCTTTGTT

>15858_15858_2_CEP350-TDRD5_CEP350_chr1_180010383_ENST00000367607_TDRD5_chr1_179659831_ENST00000367614_length(amino acids)=1414AA_BP=
MRSSKSKEVPLPNPRNSQSKDTVQADITTSWDALSQTKAALRHIENKLEVAPTSTAVCDSVMDTKKSSTSATRKISRKDGRYLDDSWVNA
PISKSTKSRKEKSRSPLRATTLESNVKKNNRVEFREPLVSYREIHGAPSNFSSSHLESKHVYCVDVNEEKTESGNWMIGSREERNIRSCD
FESSQSSVINDTVVRFLNDRPAIDALQNSECLIRMGASMRTEEEMPNRTKGSENNLKLSVNNMAHDTDPKALRLTDSSPSSTSTSNSQRL
DILKRRQHDVKLEKLKERIRKQWEHSEETNGRGQKLGHIDHPVMVVNVDNSVTAKVRKVATAPPAPAYKGFNPSETKIRTPDGKVWQEAE
FQNMSRELYRDLALHFADDISIKEKPAEKSKEKKVVKPVRKVQKVAQLSSTECRTGSSHLISTSSWRDGQKLVKKILGPAPRMEPKEQRT
ASSDRGGRERTAKSGGHIGRAESDPRLDVLHRHLQRNSERSRSKSRSENNIKKLASSLPDNKQEENTALNKDFLPIEIRGILDDLQLDST
AHTAKQDTVELQNQKSSAPVHAPRSHSPVKRKPDKITANEDPPVISKRRHYDTDEVRQYIVRQQEERKRKQNEEKKAQKEATEQKNKRLQ
ELYRKQKEAFTKVKNVPPSEPSATRRLQETYSKLLLEKTLLEEPSHQHVTQETQAKPGYQPSGESDKENKVQERPPSASSSSDMSLSEPP
QPLARKDLMESTWMQPERLSPQVHHSQPQPFAGTAGSLLSHLLSLEHVGILHKDFESILPTRKNHNMASRPLTFTPQPYVTSPAAYTDAL
LKPSASQYKSKLDRIEALKATAASLSSRIESEAKKLAGASINYGSAWNTEYDVQQAPQEDGPWTKAVTPPVKDDNEDVFSARIQKMLGSC
VSHATFDDDLPGVGNLSEFKKLPEMIRPQSAISSFRVRSPGPKPEGLLAQLCKRQTDSSSSDMQACSQDKAKISLGSSIDSVSEGPLLSE
GSLSEEEGDQDGQPLLKVAEILKEKEFCPGERNSYEPIKEFQKEAEKFLPLFGHIGGTQSKGPWEELAKGSPHSVINIFTKSYQLYGKGF
EDKLDRGTSTSRPLNATATPLSGVSYEDDFVSSPGTGTSTEKKSTLEPHSTLSPQEDHSNRKSAYDPSSVDVTSQHSSGAQSAASSRSST
SSKGKKGKKEKTEWLDSFTGNVQNSLLDEEKAERGSHQGKKSGTSSKLSVKDFEQTLDTDSTLEDLSGHSVSVSSDKGRSQKTPTSPLSP
SSQKSLQFDVAGTSSERSKSSVMPPTITGFKPNAPLTDLNPAASRTTTENMAPIPGSKRFSPAGLHHRMAAELSYLNAIEESVRQLSDVE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CEP350-TDRD5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CEP350-TDRD5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CEP350-TDRD5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source