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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP70-PCCB (FusionGDB2 ID:15884)

Fusion Gene Summary for CEP70-PCCB

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP70-PCCB
Fusion gene ID: 15884
HgeneTgene
Gene symbol

CEP70

PCCB

Gene ID

80321

5096

Gene namecentrosomal protein 70propionyl-CoA carboxylase subunit beta
SynonymsBITE-
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 70 kDacentrosomal protein 70kDap10-binding proteintesticular tissue protein Li 36propionyl-CoA carboxylase beta chain, mitochondrialPCCase subunit betapropanoyl-CoA:carbon dioxide ligase subunit betapropionyl CoA carboxylase, beta polypeptidepropionyl Coenzyme A carboxylase, beta polypeptidepropionyl-CoA carboxylase beta subunit
Modification date2020032720200313
UniProtAcc

Q8NHQ1

.
Ensembl transtripts involved in fusion geneENST00000264982, ENST00000464035, 
ENST00000481834, ENST00000484888, 
ENST00000542237, ENST00000478673, 
ENST00000489254, 		ENST00000474833, 
ENST00000251654, ENST00000462637, 
ENST00000466072, ENST00000468777, 
ENST00000469217, ENST00000478469, 
ENST00000482086, ENST00000483687, 
ENST00000490504, ENST00000471595, 
Fusion gene scores* DoF score11 X 13 X 6=85812 X 11 X 8=1056
# samples 1415
** MAII scorelog2(14/858*10)=-2.61555082055458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1056*10)=-2.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP70 [Title/Abstract] AND PCCB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP70(138289160)-PCCB(136035783), # samples:1
Anticipated loss of major functional domain due to fusion event.CEP70-PCCB seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CEP70-PCCB seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CEP70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCCB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-3653-01ACEP70chr3

138289160

-PCCBchr3

136035783

+


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Fusion Gene ORF analysis for CEP70-PCCB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000264982ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-3UTRENST00000464035ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-3UTRENST00000481834ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-3UTRENST00000484888ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-3UTRENST00000542237ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000264982ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000464035ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000481834ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000484888ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
5CDS-intronENST00000542237ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-3CDSENST00000478673ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-3UTRENST00000478673ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
5UTR-intronENST00000478673ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+
Frame-shiftENST00000464035ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
Frame-shiftENST00000484888ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
In-frameENST00000264982ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
In-frameENST00000481834ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
In-frameENST00000542237ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-3CDSENST00000489254ENST00000471595CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-3UTRENST00000489254ENST00000474833CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000251654CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000462637CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000466072CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000468777CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000469217CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000478469CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000482086CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000483687CEP70chr3

138289160

-PCCBchr3

136035783

+
intron-intronENST00000489254ENST00000490504CEP70chr3

138289160

-PCCBchr3

136035783

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264982CEP70chr3138289160-ENST00000471595PCCBchr3136035783+58387322671418383
ENST00000542237CEP70chr3138289160-ENST00000471595PCCBchr3136035783+56565501451236363
ENST00000481834CEP70chr3138289160-ENST00000471595PCCBchr3136035783+57306241591310383

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264982ENST00000471595CEP70chr3138289160-PCCBchr3136035783+0.0004982360.9995017
ENST00000542237ENST00000471595CEP70chr3138289160-PCCBchr3136035783+0.0007205520.99927944
ENST00000481834ENST00000471595CEP70chr3138289160-PCCBchr3136035783+0.0004716030.9995284

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Fusion Genomic Features for CEP70-PCCB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP70chr3138289159-PCCBchr3136035782+0.0006177880.99938214
CEP70chr3138289159-PCCBchr3136035782+0.0006177880.99938214

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CEP70-PCCB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:138289160/chr3:136035783)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP70

Q8NHQ1

.
FUNCTION: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCCBchr3:138289160chr3:136035783ENST00000251654815325_358322540.0RegionAcyl-CoA binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP70chr3:138289160chr3:136035783ENST00000264982-618254_326155598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000264982-61875_179155598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000464035-56254_326155213.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000464035-5675_179155213.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000481834-616254_326155555.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000481834-61675_179155555.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000484888-618254_326155598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000484888-61875_179155598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000542237-517254_326135578.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000542237-51775_179135578.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138289160chr3:136035783ENST00000264982-618483_516155598.0RepeatNote=TPR
HgeneCEP70chr3:138289160chr3:136035783ENST00000464035-56483_516155213.0RepeatNote=TPR
HgeneCEP70chr3:138289160chr3:136035783ENST00000481834-616483_516155555.0RepeatNote=TPR
HgeneCEP70chr3:138289160chr3:136035783ENST00000484888-618483_516155598.0RepeatNote=TPR
HgeneCEP70chr3:138289160chr3:136035783ENST00000542237-517483_516135578.0RepeatNote=TPR
TgenePCCBchr3:138289160chr3:136035783ENST00000251654815294_533322540.0DomainCoA carboxyltransferase C-terminal
TgenePCCBchr3:138289160chr3:136035783ENST0000025165481532_290322540.0DomainCoA carboxyltransferase N-terminal
TgenePCCBchr3:138289160chr3:136035783ENST00000469217916294_533342560.0DomainCoA carboxyltransferase C-terminal
TgenePCCBchr3:138289160chr3:136035783ENST0000046921791632_290342560.0DomainCoA carboxyltransferase N-terminal
TgenePCCBchr3:138289160chr3:136035783ENST0000025165481532_533322540.0RegionCarboxyltransferase
TgenePCCBchr3:138289160chr3:136035783ENST00000469217916325_358342560.0RegionAcyl-CoA binding
TgenePCCBchr3:138289160chr3:136035783ENST0000046921791632_533342560.0RegionCarboxyltransferase


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Fusion Gene Sequence for CEP70-PCCB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15884_15884_1_CEP70-PCCB_CEP70_chr3_138289160_ENST00000264982_PCCB_chr3_136035783_ENST00000471595_length(transcript)=5838nt_BP=732nt
ATTCGCAGGCCAAAGAGGGGCTGGCCCTCGACGCGCTCGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGG
CCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACA
TGAGACTCGTTGGGTGATCATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGTAACTATG
TTTCCGGTAGCCCCTAAACCCCAGGATTCCAGTCAACCATCAGACAGACTCATGACTGAAAAACAGCAGGAAGAAGCAGAATGGGAAAGC
ATAAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAG
TCATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAAT
CAACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGT
GTGAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAG
AAAACTTTACAGGTTGTTGATGAGCGTGAATTTTTTGAGATCATGCCCAATTATGCCAAGAACATCATTGTTGGTTTTGCAAGAATGAAT
GGGAGGACTGTTGGAATTGTTGGCAACCAACCTAAGGTGGCCTCAGGATGCTTGGATATTAATTCATCTGTGAAAGGGGCTCGTTTTGTC
AGATTCTGTGATGCATTCAATATTCCACTCATCACTTTTGTTGATGTCCCTGGCTTTCTACCTGGCACAGCACAGGAATACGGGGGCATC
ATCCGGCATGGTGCCAAGCTTCTCTACGCATTTGCTGAGGCAACTGTACCCAAAGTCACAGTCATCACCAGGAAGGCCTATGGAGGTGCC
TATGATGTCATGAGCTCTAAGCACCTTTGTGGTGATACCAACTATGCCTGGCCCACCGCAGAGATTGCAGTCATGGGAGCAAAGGGCGCT
GTGGAGATCATCTTCAAAGGGCATGAGAATGTGGAAGCTGCTCAGGCAGAGTACATCGAGAAGTTTGCCAACCCTTTCCCTGCAGCAGTG
CGAGGGTTTGTGGATGACATCATCCAACCTTCTTCCACACGTGCCCGAATCTGCTGTGACCTGGATGTCTTGGCCAGCAAGAAGGTAAGA
GTCCAAGAAGTGTTTCACCAGGTTGTGCAGTCTGGACACCGAGATGGTAGAGGGGCTGTAAGATGGTAGAGGAACCAGCTCAGGAGAGCA
GCTGGGCTAGCAGCTTTACGGAAGCCTTGGATGGTGGGGAAACTCCCGTACAGAAACTCAGCTGGTCAAAGAAACTCAAAGCCACAAGAC
CTTGGAAGCTTTGTCAAGTGGACCAGCCTCCATGGACCACGGAATACCTTGAGAGTAATGACAGTTGAGTGTTCTCTTGTGTGGGAATGC
CTTCCCCAGCTGGTGCCCTCACCTTAAAGGGAAAAAGAAAATACACTGAATTTTGTAAATGGGAAATACTTGGGTCCACTGAGCTGATAG
CTGACAAGTGTCTGTCTTTAAACTGAGAGCAGATAATATGGTGAGCTGTGGTGTAGGAAGCACTGCTAGGGTCTTGCTGGTCCTGCCCCG
CCTTGTGTTAATCCAGTTCCTCCTGAGCTACACAGCTGACAAGTGGTGAAGCTGGGATTTGAACTCAGATGGGTTTGACCCCAGCCAAGC
CTGTGTTCTGATCATTTCAAAGTACTACCACTCAGCTGATGAGGAAGGTGAGATGGACTTCTAAGGGTTGGCCTAAGAGTAGGGGTGAGG
GAGGTTGGTGGTCTGTTCCCCTGGGCTTGTCTTAACCCAGAAAGCTACTACATTTAGACAGCTTTCCTATCTCCCGCATGATTCTCTTGC
AAAGCAGTACCAACAGATGGCCAGTCATCTTTTTGAGTTGCTAGAGTAATGGGGAGCACATCCACAATACACCCTTCTAATGCTTGTTAG
AAAGTGCTTTTGTTGCAAAGTTCTTCTAGCTTCTTTTTTTGACCCTGTCTTGGTCTCCCCAGCCCAACTTTCTGCCTCTGGTTGCACTGA
TACTTTGTCCTGGTGCTGGTGCTTAAGATGTGGTCTGCTCAGCCAAAGAAGTCTGTGAAGGATACTCACCCACATGTGGAGTTGATGAAT
CAGCCCTCTTCACCTATTCAACAGATGTGACTGTTTTGTCTTTCTGGTTCCAAAGGATTTCTGGAGAGCTATGACTTTACCCTTTTAGAA
GTATTGGTCCTCATACTCTGTGCACCTCTGATGTCAGCATGGGATTTCTACAATTCCAAGCAGGAGTTGCAGCCACTTGATAGGCAGTGC
CTCAGTCTGGGGCCTCTGTGGAATCCAGCTGGCATATTCCAGCCAATGTGGCAGCCTCAATAGTTAGTTAAGTTTTGACCATGTCCCTAC
TGTCCTGGGTGGTGAAAATACTCCCTTTATGTGTCCTTGGGAGCAGAAAGATGCTCTTCAAAAAGTGGTGCCTGATGGAGATCTCCACAG
AACAAGACACTCAGAAGGGCAGGGATAGAATCTTACCTGAGCTTGGTCTAGTATGAAAAGCCTAAGGCTGGGTGCGATGGCCCATGCCCT
GTAATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATTGCTTGAGCTCAGTTCATGACCGGCCTGGGCAACATGGTGAAAGCCTGTCTCT
ACTAAAAATACAAAACTTAGCTGGGCGTGGTGGTGGGTGCCTGTAATTCCAGCTACTTGAGAGCCTGAGGCAGGAGAATCTCTTGAACCC
CAGAGGCGGAGGTTGCTGTGAGCTGAGATCACACCATTGTACTCCAGCCTGGGTGACAGACCGAGACCCTGTCTTCACTTACCGCCCCCC
CCCCCCCCCCGAAAAAAAAAAGGCAAGCCTGAGTGGCATCAAACCTTTGTTTCCCATGAATATACTAGTCCCTGCTTGATGGACTGTTAC
CTGGGAACAGGGGCAAACAGGGAGTTACAGTCAAGCCACAAATGGGAGATTTGCAAGCCTGACCCAAGCCTGAAAGTGCTCATCTAGTCT
CATACTCTTGTAACCATCTAGATGAGCTGTTACAGACCATCCTTAAATGACCTTCCTTCCTTGGCTGTCTGGAAAGCTTGCTTGCTGATT
TGTCTCCCACACCTTTGCCTTTTTTGCATAGGCATATTAGGCCATTTAAGGAACTCACCCCCTATTGCCAGACCCATGAAGTGTGTAGGG
TATGACTTCTTAAAGAAAGAGTGAGGAGGTCTAATGCCAAGAGAAACTTTTTAAGACAGTCTGGCTCTGTTACCTAGATTGGAGTGCAGT
AGTGGTGCAATCTTGGCTCACTGCAACAACCTCCACCTTGTGGGCTCAAGCCATCCTCCTACCTTAGCCTCACGAGTAGCTGGTGTGCGC
CATCATACGCAGCTAATTTTTGTATTTTTTGTAGAGGAGTTTTACCATGCTACCCAGGCTGGTCTCGAACTCTTGAGCTCAAGTGATCCA
CTCACCTTGGCCTTCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCTGAAAACTTCATTTCTGTAGCTGCATTGACTCTAT
GTGGTCTTCAAAAGGGCACTGCCAGGGTGCAATTATGCATGTAAGCCCAGAGTCTCAAGCCGTGAGGACCCATGCTACAGGCCAGTGGAT
GGGTGTTCCCTGAATGCCTCATGCAAAACTCAGTTTGCAAGAGACTCCCTCTTAAACCACAGATGACTTGGCCTACACACACTCCAGAGA
AATCTAAGGAATGAAAGAAAGTGAGCTATTCCTAAATTCTGCTTTCTTAAAAAAAATTAAAAAGCCAAAACAACAAAACCACCAACTCAC
TAATAAGGTTAACTTGCTGCCATTTAACAGATTATCAGAAATTGCAAACTCTCTCAAGAGCCACAGGACAGAAAATCATCTCTTTAAAGC
CATACCTGGTAGAAACAATAGGATGACTACCACAAGCCTGATTTTGAATAGTTTATTAAAGGAAAGGTGAAGCATCAGTTTCAAATTGTA
CAAAAGGAAAAAAAACCTCATATTGCAAATGTACAATTTACAGAATTACTAGCAAAACCAATCAAGGAGACACCGAAAATACAAAAATTT
GATTGACTTCAAACTGAACTGGAAACCCATTGGAGTAGATATTTAGCCTTTTTGTGTGGCATGGTAGTCTACAATTCTGTCAGCATCTGT
TTTCCATACAAGACTGTCACGCAAAGGATCAATTTGTGCATGTGCCAGGGCACCTCATGGCTTGCTCCCTGGCCAAAACCACAGGCAGGC
AGGGCTGGGGTGGACAGTCCAGTCATTCCTGCACCTTCACTTCCAGTGAAGCCCACAATTCTGGGAGAAAGTGAGGCCCCAGCTCCCCTA
ACTGGAGCCCAAGAATTGCTGAATTAGCAGAGAAGATATTTTTGGTGACCAGGTTTTTTTCAGAACTGTACAAATGTTGAGAAAAATGTT
TTGTGTCTTTACTAAAAGGATGAATAAAATCATCCATCATCATCTTGCTTTCCCGCACAAAAGATGATCACTGGGTGTGCAGAATTTTAA
AAAATGTTTTTCGTATTTGATAAAAAGGGAAAGCCTCATGATTCTGTTGCAGCTACTTTAAAAACCAGCCCAGAAACAGCTGTGGATGAA
TTGGTTTGGAAATTCTGAGGCTTACTTTAGAAATCAGAAAGGAAGAGAGAGACTAAGTGGGGTTTTTAAAACAATAGCAGCAAGTCATAA
AAGTCTAGGCAGAATGTAACTCTAAACCATTGTAGACTGTCCTGAAGATTCATAATTTCTTTCCCCAAAAGAATTATTCTTAATATGCAC
ATTTAACACTGAAATGTAGCTGTAATTCAAGGTAAGCTTAGGAACTTCACCCTCTAAGCACAGACTTCTATGCAGCACATACTTCTATAA
TCAGTAAACTTAATTCACAAAATTAGCGCATAAGGGTATTAAGTGCATGGGAAGTAAACACAGTTATGTTACACTTAAAATTACTTTTGA
ATGATTGATAAAGGATTTCTTCATGATTGATTATCTTAAGAAAATGGAAGTCTGTGTAACTTGAATTTGGCAGGGCATGAAATAAGTGGT
AAAAACAGCAAACTGATAACTTGAGAATCATTTTCGTTTTACTGAGAATACTTTATTTGCTGGTAGAAGTTGCTAAAAATGCACAGAACA
AATACCAATAGAAAATGCACTGTATTTGAATCTCCCTAGTCTATATAAAATGAACGGTGTACAGCATCTGTTGGAAAAATGGCTGCATGG
ACATTTCTTATTTTATGCCCACTTATAAATAAAAATAAACCTTTTATTCAAGAGTATATAAAATCTGGGAATTCATATCCATATCCACAG
AGGGTGTGTGGTTTTTGGCAGAGATGTACTATGTCAGAATTTCATCTTAGCTTGTCAATGTTCTGCTCCTTCATTATTTGTGTTCCACAA
AGGTCAACCAAATCCAGTGAACTCCAAAACACTCTTCGCAATTAGGATGAGCTGCTTACTCATAGGTTTAATAAAAATGGTTAGCTTTTA

>15884_15884_1_CEP70-PCCB_CEP70_chr3_138289160_ENST00000264982_PCCB_chr3_136035783_ENST00000471595_length(amino acids)=383AA_BP=153
MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIET
NQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVVDEREFFEIMPNYAKNIIVGFARM
NGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGG
AYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKV

--------------------------------------------------------------
>15884_15884_2_CEP70-PCCB_CEP70_chr3_138289160_ENST00000481834_PCCB_chr3_136035783_ENST00000471595_length(transcript)=5730nt_BP=624nt
AGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGAT
CATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGTAACTATGTTTCCGGTAGCCCCTAAA
CCCCAGGATTCCAGTCAACCATCAGACAGACTCATGACTGAAAAACAGCAGGAAGAAGCAGAATGGGAAAGCATAAATGTGCTATTGATG
ATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAGTCATCACAAAGGATGAGA
CAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAATCAACAGCTTAGAAATGAA
CTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGTGTGAAATCCAAAATTGGT
GAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAGAAAACTTTACAGGTTGTT
GATGAGCGTGAATTTTTTGAGATCATGCCCAATTATGCCAAGAACATCATTGTTGGTTTTGCAAGAATGAATGGGAGGACTGTTGGAATT
GTTGGCAACCAACCTAAGGTGGCCTCAGGATGCTTGGATATTAATTCATCTGTGAAAGGGGCTCGTTTTGTCAGATTCTGTGATGCATTC
AATATTCCACTCATCACTTTTGTTGATGTCCCTGGCTTTCTACCTGGCACAGCACAGGAATACGGGGGCATCATCCGGCATGGTGCCAAG
CTTCTCTACGCATTTGCTGAGGCAACTGTACCCAAAGTCACAGTCATCACCAGGAAGGCCTATGGAGGTGCCTATGATGTCATGAGCTCT
AAGCACCTTTGTGGTGATACCAACTATGCCTGGCCCACCGCAGAGATTGCAGTCATGGGAGCAAAGGGCGCTGTGGAGATCATCTTCAAA
GGGCATGAGAATGTGGAAGCTGCTCAGGCAGAGTACATCGAGAAGTTTGCCAACCCTTTCCCTGCAGCAGTGCGAGGGTTTGTGGATGAC
ATCATCCAACCTTCTTCCACACGTGCCCGAATCTGCTGTGACCTGGATGTCTTGGCCAGCAAGAAGGTAAGAGTCCAAGAAGTGTTTCAC
CAGGTTGTGCAGTCTGGACACCGAGATGGTAGAGGGGCTGTAAGATGGTAGAGGAACCAGCTCAGGAGAGCAGCTGGGCTAGCAGCTTTA
CGGAAGCCTTGGATGGTGGGGAAACTCCCGTACAGAAACTCAGCTGGTCAAAGAAACTCAAAGCCACAAGACCTTGGAAGCTTTGTCAAG
TGGACCAGCCTCCATGGACCACGGAATACCTTGAGAGTAATGACAGTTGAGTGTTCTCTTGTGTGGGAATGCCTTCCCCAGCTGGTGCCC
TCACCTTAAAGGGAAAAAGAAAATACACTGAATTTTGTAAATGGGAAATACTTGGGTCCACTGAGCTGATAGCTGACAAGTGTCTGTCTT
TAAACTGAGAGCAGATAATATGGTGAGCTGTGGTGTAGGAAGCACTGCTAGGGTCTTGCTGGTCCTGCCCCGCCTTGTGTTAATCCAGTT
CCTCCTGAGCTACACAGCTGACAAGTGGTGAAGCTGGGATTTGAACTCAGATGGGTTTGACCCCAGCCAAGCCTGTGTTCTGATCATTTC
AAAGTACTACCACTCAGCTGATGAGGAAGGTGAGATGGACTTCTAAGGGTTGGCCTAAGAGTAGGGGTGAGGGAGGTTGGTGGTCTGTTC
CCCTGGGCTTGTCTTAACCCAGAAAGCTACTACATTTAGACAGCTTTCCTATCTCCCGCATGATTCTCTTGCAAAGCAGTACCAACAGAT
GGCCAGTCATCTTTTTGAGTTGCTAGAGTAATGGGGAGCACATCCACAATACACCCTTCTAATGCTTGTTAGAAAGTGCTTTTGTTGCAA
AGTTCTTCTAGCTTCTTTTTTTGACCCTGTCTTGGTCTCCCCAGCCCAACTTTCTGCCTCTGGTTGCACTGATACTTTGTCCTGGTGCTG
GTGCTTAAGATGTGGTCTGCTCAGCCAAAGAAGTCTGTGAAGGATACTCACCCACATGTGGAGTTGATGAATCAGCCCTCTTCACCTATT
CAACAGATGTGACTGTTTTGTCTTTCTGGTTCCAAAGGATTTCTGGAGAGCTATGACTTTACCCTTTTAGAAGTATTGGTCCTCATACTC
TGTGCACCTCTGATGTCAGCATGGGATTTCTACAATTCCAAGCAGGAGTTGCAGCCACTTGATAGGCAGTGCCTCAGTCTGGGGCCTCTG
TGGAATCCAGCTGGCATATTCCAGCCAATGTGGCAGCCTCAATAGTTAGTTAAGTTTTGACCATGTCCCTACTGTCCTGGGTGGTGAAAA
TACTCCCTTTATGTGTCCTTGGGAGCAGAAAGATGCTCTTCAAAAAGTGGTGCCTGATGGAGATCTCCACAGAACAAGACACTCAGAAGG
GCAGGGATAGAATCTTACCTGAGCTTGGTCTAGTATGAAAAGCCTAAGGCTGGGTGCGATGGCCCATGCCCTGTAATCCCAGCACTTTGG
GAGGCCAAGGCAGGTGGATTGCTTGAGCTCAGTTCATGACCGGCCTGGGCAACATGGTGAAAGCCTGTCTCTACTAAAAATACAAAACTT
AGCTGGGCGTGGTGGTGGGTGCCTGTAATTCCAGCTACTTGAGAGCCTGAGGCAGGAGAATCTCTTGAACCCCAGAGGCGGAGGTTGCTG
TGAGCTGAGATCACACCATTGTACTCCAGCCTGGGTGACAGACCGAGACCCTGTCTTCACTTACCGCCCCCCCCCCCCCCCCGAAAAAAA
AAAGGCAAGCCTGAGTGGCATCAAACCTTTGTTTCCCATGAATATACTAGTCCCTGCTTGATGGACTGTTACCTGGGAACAGGGGCAAAC
AGGGAGTTACAGTCAAGCCACAAATGGGAGATTTGCAAGCCTGACCCAAGCCTGAAAGTGCTCATCTAGTCTCATACTCTTGTAACCATC
TAGATGAGCTGTTACAGACCATCCTTAAATGACCTTCCTTCCTTGGCTGTCTGGAAAGCTTGCTTGCTGATTTGTCTCCCACACCTTTGC
CTTTTTTGCATAGGCATATTAGGCCATTTAAGGAACTCACCCCCTATTGCCAGACCCATGAAGTGTGTAGGGTATGACTTCTTAAAGAAA
GAGTGAGGAGGTCTAATGCCAAGAGAAACTTTTTAAGACAGTCTGGCTCTGTTACCTAGATTGGAGTGCAGTAGTGGTGCAATCTTGGCT
CACTGCAACAACCTCCACCTTGTGGGCTCAAGCCATCCTCCTACCTTAGCCTCACGAGTAGCTGGTGTGCGCCATCATACGCAGCTAATT
TTTGTATTTTTTGTAGAGGAGTTTTACCATGCTACCCAGGCTGGTCTCGAACTCTTGAGCTCAAGTGATCCACTCACCTTGGCCTTCCAA
AGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCTGAAAACTTCATTTCTGTAGCTGCATTGACTCTATGTGGTCTTCAAAAGGGCA
CTGCCAGGGTGCAATTATGCATGTAAGCCCAGAGTCTCAAGCCGTGAGGACCCATGCTACAGGCCAGTGGATGGGTGTTCCCTGAATGCC
TCATGCAAAACTCAGTTTGCAAGAGACTCCCTCTTAAACCACAGATGACTTGGCCTACACACACTCCAGAGAAATCTAAGGAATGAAAGA
AAGTGAGCTATTCCTAAATTCTGCTTTCTTAAAAAAAATTAAAAAGCCAAAACAACAAAACCACCAACTCACTAATAAGGTTAACTTGCT
GCCATTTAACAGATTATCAGAAATTGCAAACTCTCTCAAGAGCCACAGGACAGAAAATCATCTCTTTAAAGCCATACCTGGTAGAAACAA
TAGGATGACTACCACAAGCCTGATTTTGAATAGTTTATTAAAGGAAAGGTGAAGCATCAGTTTCAAATTGTACAAAAGGAAAAAAAACCT
CATATTGCAAATGTACAATTTACAGAATTACTAGCAAAACCAATCAAGGAGACACCGAAAATACAAAAATTTGATTGACTTCAAACTGAA
CTGGAAACCCATTGGAGTAGATATTTAGCCTTTTTGTGTGGCATGGTAGTCTACAATTCTGTCAGCATCTGTTTTCCATACAAGACTGTC
ACGCAAAGGATCAATTTGTGCATGTGCCAGGGCACCTCATGGCTTGCTCCCTGGCCAAAACCACAGGCAGGCAGGGCTGGGGTGGACAGT
CCAGTCATTCCTGCACCTTCACTTCCAGTGAAGCCCACAATTCTGGGAGAAAGTGAGGCCCCAGCTCCCCTAACTGGAGCCCAAGAATTG
CTGAATTAGCAGAGAAGATATTTTTGGTGACCAGGTTTTTTTCAGAACTGTACAAATGTTGAGAAAAATGTTTTGTGTCTTTACTAAAAG
GATGAATAAAATCATCCATCATCATCTTGCTTTCCCGCACAAAAGATGATCACTGGGTGTGCAGAATTTTAAAAAATGTTTTTCGTATTT
GATAAAAAGGGAAAGCCTCATGATTCTGTTGCAGCTACTTTAAAAACCAGCCCAGAAACAGCTGTGGATGAATTGGTTTGGAAATTCTGA
GGCTTACTTTAGAAATCAGAAAGGAAGAGAGAGACTAAGTGGGGTTTTTAAAACAATAGCAGCAAGTCATAAAAGTCTAGGCAGAATGTA
ACTCTAAACCATTGTAGACTGTCCTGAAGATTCATAATTTCTTTCCCCAAAAGAATTATTCTTAATATGCACATTTAACACTGAAATGTA
GCTGTAATTCAAGGTAAGCTTAGGAACTTCACCCTCTAAGCACAGACTTCTATGCAGCACATACTTCTATAATCAGTAAACTTAATTCAC
AAAATTAGCGCATAAGGGTATTAAGTGCATGGGAAGTAAACACAGTTATGTTACACTTAAAATTACTTTTGAATGATTGATAAAGGATTT
CTTCATGATTGATTATCTTAAGAAAATGGAAGTCTGTGTAACTTGAATTTGGCAGGGCATGAAATAAGTGGTAAAAACAGCAAACTGATA
ACTTGAGAATCATTTTCGTTTTACTGAGAATACTTTATTTGCTGGTAGAAGTTGCTAAAAATGCACAGAACAAATACCAATAGAAAATGC
ACTGTATTTGAATCTCCCTAGTCTATATAAAATGAACGGTGTACAGCATCTGTTGGAAAAATGGCTGCATGGACATTTCTTATTTTATGC
CCACTTATAAATAAAAATAAACCTTTTATTCAAGAGTATATAAAATCTGGGAATTCATATCCATATCCACAGAGGGTGTGTGGTTTTTGG
CAGAGATGTACTATGTCAGAATTTCATCTTAGCTTGTCAATGTTCTGCTCCTTCATTATTTGTGTTCCACAAAGGTCAACCAAATCCAGT
GAACTCCAAAACACTCTTCGCAATTAGGATGAGCTGCTTACTCATAGGTTTAATAAAAATGGTTAGCTTTTAAAACATAAAAAGGCAAAA

>15884_15884_2_CEP70-PCCB_CEP70_chr3_138289160_ENST00000481834_PCCB_chr3_136035783_ENST00000471595_length(amino acids)=383AA_BP=153
MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIET
NQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVVDEREFFEIMPNYAKNIIVGFARM
NGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGG
AYDVMSSKHLCGDTNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKV

--------------------------------------------------------------
>15884_15884_3_CEP70-PCCB_CEP70_chr3_138289160_ENST00000542237_PCCB_chr3_136035783_ENST00000471595_length(transcript)=5656nt_BP=550nt
AGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGAT
CATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGCAGGAAGAAGCAGAATGGGAAAGCAT
AAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAGTC
ATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAATCA
ACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGTGT
GAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAGAA
AACTTTACAGGTTGTTGATGAGCGTGAATTTTTTGAGATCATGCCCAATTATGCCAAGAACATCATTGTTGGTTTTGCAAGAATGAATGG
GAGGACTGTTGGAATTGTTGGCAACCAACCTAAGGTGGCCTCAGGATGCTTGGATATTAATTCATCTGTGAAAGGGGCTCGTTTTGTCAG
ATTCTGTGATGCATTCAATATTCCACTCATCACTTTTGTTGATGTCCCTGGCTTTCTACCTGGCACAGCACAGGAATACGGGGGCATCAT
CCGGCATGGTGCCAAGCTTCTCTACGCATTTGCTGAGGCAACTGTACCCAAAGTCACAGTCATCACCAGGAAGGCCTATGGAGGTGCCTA
TGATGTCATGAGCTCTAAGCACCTTTGTGGTGATACCAACTATGCCTGGCCCACCGCAGAGATTGCAGTCATGGGAGCAAAGGGCGCTGT
GGAGATCATCTTCAAAGGGCATGAGAATGTGGAAGCTGCTCAGGCAGAGTACATCGAGAAGTTTGCCAACCCTTTCCCTGCAGCAGTGCG
AGGGTTTGTGGATGACATCATCCAACCTTCTTCCACACGTGCCCGAATCTGCTGTGACCTGGATGTCTTGGCCAGCAAGAAGGTAAGAGT
CCAAGAAGTGTTTCACCAGGTTGTGCAGTCTGGACACCGAGATGGTAGAGGGGCTGTAAGATGGTAGAGGAACCAGCTCAGGAGAGCAGC
TGGGCTAGCAGCTTTACGGAAGCCTTGGATGGTGGGGAAACTCCCGTACAGAAACTCAGCTGGTCAAAGAAACTCAAAGCCACAAGACCT
TGGAAGCTTTGTCAAGTGGACCAGCCTCCATGGACCACGGAATACCTTGAGAGTAATGACAGTTGAGTGTTCTCTTGTGTGGGAATGCCT
TCCCCAGCTGGTGCCCTCACCTTAAAGGGAAAAAGAAAATACACTGAATTTTGTAAATGGGAAATACTTGGGTCCACTGAGCTGATAGCT
GACAAGTGTCTGTCTTTAAACTGAGAGCAGATAATATGGTGAGCTGTGGTGTAGGAAGCACTGCTAGGGTCTTGCTGGTCCTGCCCCGCC
TTGTGTTAATCCAGTTCCTCCTGAGCTACACAGCTGACAAGTGGTGAAGCTGGGATTTGAACTCAGATGGGTTTGACCCCAGCCAAGCCT
GTGTTCTGATCATTTCAAAGTACTACCACTCAGCTGATGAGGAAGGTGAGATGGACTTCTAAGGGTTGGCCTAAGAGTAGGGGTGAGGGA
GGTTGGTGGTCTGTTCCCCTGGGCTTGTCTTAACCCAGAAAGCTACTACATTTAGACAGCTTTCCTATCTCCCGCATGATTCTCTTGCAA
AGCAGTACCAACAGATGGCCAGTCATCTTTTTGAGTTGCTAGAGTAATGGGGAGCACATCCACAATACACCCTTCTAATGCTTGTTAGAA
AGTGCTTTTGTTGCAAAGTTCTTCTAGCTTCTTTTTTTGACCCTGTCTTGGTCTCCCCAGCCCAACTTTCTGCCTCTGGTTGCACTGATA
CTTTGTCCTGGTGCTGGTGCTTAAGATGTGGTCTGCTCAGCCAAAGAAGTCTGTGAAGGATACTCACCCACATGTGGAGTTGATGAATCA
GCCCTCTTCACCTATTCAACAGATGTGACTGTTTTGTCTTTCTGGTTCCAAAGGATTTCTGGAGAGCTATGACTTTACCCTTTTAGAAGT
ATTGGTCCTCATACTCTGTGCACCTCTGATGTCAGCATGGGATTTCTACAATTCCAAGCAGGAGTTGCAGCCACTTGATAGGCAGTGCCT
CAGTCTGGGGCCTCTGTGGAATCCAGCTGGCATATTCCAGCCAATGTGGCAGCCTCAATAGTTAGTTAAGTTTTGACCATGTCCCTACTG
TCCTGGGTGGTGAAAATACTCCCTTTATGTGTCCTTGGGAGCAGAAAGATGCTCTTCAAAAAGTGGTGCCTGATGGAGATCTCCACAGAA
CAAGACACTCAGAAGGGCAGGGATAGAATCTTACCTGAGCTTGGTCTAGTATGAAAAGCCTAAGGCTGGGTGCGATGGCCCATGCCCTGT
AATCCCAGCACTTTGGGAGGCCAAGGCAGGTGGATTGCTTGAGCTCAGTTCATGACCGGCCTGGGCAACATGGTGAAAGCCTGTCTCTAC
TAAAAATACAAAACTTAGCTGGGCGTGGTGGTGGGTGCCTGTAATTCCAGCTACTTGAGAGCCTGAGGCAGGAGAATCTCTTGAACCCCA
GAGGCGGAGGTTGCTGTGAGCTGAGATCACACCATTGTACTCCAGCCTGGGTGACAGACCGAGACCCTGTCTTCACTTACCGCCCCCCCC
CCCCCCCCGAAAAAAAAAAGGCAAGCCTGAGTGGCATCAAACCTTTGTTTCCCATGAATATACTAGTCCCTGCTTGATGGACTGTTACCT
GGGAACAGGGGCAAACAGGGAGTTACAGTCAAGCCACAAATGGGAGATTTGCAAGCCTGACCCAAGCCTGAAAGTGCTCATCTAGTCTCA
TACTCTTGTAACCATCTAGATGAGCTGTTACAGACCATCCTTAAATGACCTTCCTTCCTTGGCTGTCTGGAAAGCTTGCTTGCTGATTTG
TCTCCCACACCTTTGCCTTTTTTGCATAGGCATATTAGGCCATTTAAGGAACTCACCCCCTATTGCCAGACCCATGAAGTGTGTAGGGTA
TGACTTCTTAAAGAAAGAGTGAGGAGGTCTAATGCCAAGAGAAACTTTTTAAGACAGTCTGGCTCTGTTACCTAGATTGGAGTGCAGTAG
TGGTGCAATCTTGGCTCACTGCAACAACCTCCACCTTGTGGGCTCAAGCCATCCTCCTACCTTAGCCTCACGAGTAGCTGGTGTGCGCCA
TCATACGCAGCTAATTTTTGTATTTTTTGTAGAGGAGTTTTACCATGCTACCCAGGCTGGTCTCGAACTCTTGAGCTCAAGTGATCCACT
CACCTTGGCCTTCCAAAGTGCTGGGATTACAGGCGTGAGCCACCATGCCTGGCTGAAAACTTCATTTCTGTAGCTGCATTGACTCTATGT
GGTCTTCAAAAGGGCACTGCCAGGGTGCAATTATGCATGTAAGCCCAGAGTCTCAAGCCGTGAGGACCCATGCTACAGGCCAGTGGATGG
GTGTTCCCTGAATGCCTCATGCAAAACTCAGTTTGCAAGAGACTCCCTCTTAAACCACAGATGACTTGGCCTACACACACTCCAGAGAAA
TCTAAGGAATGAAAGAAAGTGAGCTATTCCTAAATTCTGCTTTCTTAAAAAAAATTAAAAAGCCAAAACAACAAAACCACCAACTCACTA
ATAAGGTTAACTTGCTGCCATTTAACAGATTATCAGAAATTGCAAACTCTCTCAAGAGCCACAGGACAGAAAATCATCTCTTTAAAGCCA
TACCTGGTAGAAACAATAGGATGACTACCACAAGCCTGATTTTGAATAGTTTATTAAAGGAAAGGTGAAGCATCAGTTTCAAATTGTACA
AAAGGAAAAAAAACCTCATATTGCAAATGTACAATTTACAGAATTACTAGCAAAACCAATCAAGGAGACACCGAAAATACAAAAATTTGA
TTGACTTCAAACTGAACTGGAAACCCATTGGAGTAGATATTTAGCCTTTTTGTGTGGCATGGTAGTCTACAATTCTGTCAGCATCTGTTT
TCCATACAAGACTGTCACGCAAAGGATCAATTTGTGCATGTGCCAGGGCACCTCATGGCTTGCTCCCTGGCCAAAACCACAGGCAGGCAG
GGCTGGGGTGGACAGTCCAGTCATTCCTGCACCTTCACTTCCAGTGAAGCCCACAATTCTGGGAGAAAGTGAGGCCCCAGCTCCCCTAAC
TGGAGCCCAAGAATTGCTGAATTAGCAGAGAAGATATTTTTGGTGACCAGGTTTTTTTCAGAACTGTACAAATGTTGAGAAAAATGTTTT
GTGTCTTTACTAAAAGGATGAATAAAATCATCCATCATCATCTTGCTTTCCCGCACAAAAGATGATCACTGGGTGTGCAGAATTTTAAAA
AATGTTTTTCGTATTTGATAAAAAGGGAAAGCCTCATGATTCTGTTGCAGCTACTTTAAAAACCAGCCCAGAAACAGCTGTGGATGAATT
GGTTTGGAAATTCTGAGGCTTACTTTAGAAATCAGAAAGGAAGAGAGAGACTAAGTGGGGTTTTTAAAACAATAGCAGCAAGTCATAAAA
GTCTAGGCAGAATGTAACTCTAAACCATTGTAGACTGTCCTGAAGATTCATAATTTCTTTCCCCAAAAGAATTATTCTTAATATGCACAT
TTAACACTGAAATGTAGCTGTAATTCAAGGTAAGCTTAGGAACTTCACCCTCTAAGCACAGACTTCTATGCAGCACATACTTCTATAATC
AGTAAACTTAATTCACAAAATTAGCGCATAAGGGTATTAAGTGCATGGGAAGTAAACACAGTTATGTTACACTTAAAATTACTTTTGAAT
GATTGATAAAGGATTTCTTCATGATTGATTATCTTAAGAAAATGGAAGTCTGTGTAACTTGAATTTGGCAGGGCATGAAATAAGTGGTAA
AAACAGCAAACTGATAACTTGAGAATCATTTTCGTTTTACTGAGAATACTTTATTTGCTGGTAGAAGTTGCTAAAAATGCACAGAACAAA
TACCAATAGAAAATGCACTGTATTTGAATCTCCCTAGTCTATATAAAATGAACGGTGTACAGCATCTGTTGGAAAAATGGCTGCATGGAC
ATTTCTTATTTTATGCCCACTTATAAATAAAAATAAACCTTTTATTCAAGAGTATATAAAATCTGGGAATTCATATCCATATCCACAGAG
GGTGTGTGGTTTTTGGCAGAGATGTACTATGTCAGAATTTCATCTTAGCTTGTCAATGTTCTGCTCCTTCATTATTTGTGTTCCACAAAG
GTCAACCAAATCCAGTGAACTCCAAAACACTCTTCGCAATTAGGATGAGCTGCTTACTCATAGGTTTAATAAAAATGGTTAGCTTTTAAA

>15884_15884_3_CEP70-PCCB_CEP70_chr3_138289160_ENST00000542237_PCCB_chr3_136035783_ENST00000471595_length(amino acids)=363AA_BP=133
MTEQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ
RANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVVDEREFFEIMPNYAKNIIVGFARMNGRTVGIVGNQPKVASGCLD
INSSVKGARFVRFCDAFNIPLITFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCGDTNYAWPT
AEIAVMGAKGAVEIIFKGHENVEAAQAEYIEKFANPFPAAVRGFVDDIIQPSSTRARICCDLDVLASKKVRVQEVFHQVVQSGHRDGRGA

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Fusion Gene PPI Analysis for CEP70-PCCB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP70-PCCB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP70-PCCB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource