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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP70-TNFSF10 (FusionGDB2 ID:15888)

Fusion Gene Summary for CEP70-TNFSF10

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP70-TNFSF10
Fusion gene ID: 15888
HgeneTgene
Gene symbol

CEP70

TNFSF10

Gene ID

80321

8743

Gene namecentrosomal protein 70TNF superfamily member 10
SynonymsBITEAPO2L|Apo-2L|CD253|TL2|TNLG6A|TRAIL
Cytomap

3q22.3

3q26.31

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 70 kDacentrosomal protein 70kDap10-binding proteintesticular tissue protein Li 36tumor necrosis factor ligand superfamily member 10Apo-2 ligandTNF-related apoptosis inducing ligand TRAILchemokine tumor necrosis factor ligand superfamily member 10tumor necrosis factor (ligand) family, member 10tumor necrosis factor (ligand) superf
Modification date2020032720200329
UniProtAcc

Q8NHQ1

.
Ensembl transtripts involved in fusion geneENST00000264982, ENST00000484888, 
ENST00000489254, ENST00000542237, 
ENST00000464035, ENST00000478673, 
ENST00000481834, 		ENST00000420541, 
ENST00000241261, 
Fusion gene scores* DoF score11 X 13 X 6=8585 X 4 X 4=80
# samples 146
** MAII scorelog2(14/858*10)=-2.61555082055458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP70 [Title/Abstract] AND TNFSF10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP70(138216873)-TNFSF10(172227111), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNFSF10

GO:0043065

positive regulation of apoptotic process

21525171

TgeneTNFSF10

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

21459798|21525171|22266862

TgeneTNFSF10

GO:0090200

positive regulation of release of cytochrome c from mitochondria

22266862

TgeneTNFSF10

GO:2001238

positive regulation of extrinsic apoptotic signaling pathway

20097879|21525171|22266862


check buttonFusion gene breakpoints across CEP70 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNFSF10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A9O5-01ACEP70chr3

138216873

-TNFSF10chr3

172227111

-
ChimerDB4PRADTCGA-V1-A9O5-06ACEP70chr3

138216873

-TNFSF10chr3

172227111

-
ChimerDB4PRADTCGA-V1-A9O5CEP70chr3

138216872

-TNFSF10chr3

172227111

-
ChimerDB4PRADTCGA-V1-A9O5CEP70chr3

138216873

-TNFSF10chr3

172227111

-


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Fusion Gene ORF analysis for CEP70-TNFSF10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264982ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000264982ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-
5CDS-intronENST00000484888ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000484888ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-
5CDS-intronENST00000489254ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000489254ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-
5CDS-intronENST00000542237ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
5CDS-intronENST00000542237ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-
Frame-shiftENST00000484888ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
Frame-shiftENST00000484888ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
In-frameENST00000264982ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
In-frameENST00000264982ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
In-frameENST00000489254ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
In-frameENST00000489254ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
In-frameENST00000542237ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
In-frameENST00000542237ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
intron-3CDSENST00000464035ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-3CDSENST00000464035ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
intron-3CDSENST00000478673ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-3CDSENST00000478673ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
intron-3CDSENST00000481834ENST00000241261CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-3CDSENST00000481834ENST00000241261CEP70chr3

138216872

-TNFSF10chr3

172227111

-
intron-intronENST00000464035ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-intronENST00000464035ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-
intron-intronENST00000478673ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-intronENST00000478673ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-
intron-intronENST00000481834ENST00000420541CEP70chr3

138216873

-TNFSF10chr3

172227111

-
intron-intronENST00000481834ENST00000420541CEP70chr3

138216872

-TNFSF10chr3

172227111

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264982CEP70chr3138216873-ENST00000241261TNFSF10chr3172227111-351619992672531754
ENST00000542237CEP70chr3138216873-ENST00000241261TNFSF10chr3172227111-333418171452349734
ENST00000489254CEP70chr3138216873-ENST00000241261TNFSF10chr3172227111-300914922162024602
ENST00000264982CEP70chr3138216872-ENST00000241261TNFSF10chr3172227111-351619992672531754
ENST00000542237CEP70chr3138216872-ENST00000241261TNFSF10chr3172227111-333418171452349734
ENST00000489254CEP70chr3138216872-ENST00000241261TNFSF10chr3172227111-300914922162024602

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264982ENST00000241261CEP70chr3138216873-TNFSF10chr3172227111-0.001222250.9987777
ENST00000542237ENST00000241261CEP70chr3138216873-TNFSF10chr3172227111-0.0022536240.9977464
ENST00000489254ENST00000241261CEP70chr3138216873-TNFSF10chr3172227111-0.0017185650.9982815
ENST00000264982ENST00000241261CEP70chr3138216872-TNFSF10chr3172227111-0.001222250.9987777
ENST00000542237ENST00000241261CEP70chr3138216872-TNFSF10chr3172227111-0.0022536240.9977464
ENST00000489254ENST00000241261CEP70chr3138216872-TNFSF10chr3172227111-0.0017185650.9982815

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Fusion Genomic Features for CEP70-TNFSF10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CEP70-TNFSF10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:138216873/chr3:172227111)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP70

Q8NHQ1

.
FUNCTION: Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP70chr3:138216872chr3:172227111ENST00000264982-1718254_326577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000264982-171875_179577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000484888-1718254_326577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000484888-171875_179577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000542237-1617254_326557578.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000542237-161775_179557578.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000264982-1718254_326577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000264982-171875_179577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000484888-1718254_326577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000484888-171875_179577598.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000542237-1617254_326557578.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000542237-161775_179557578.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000264982-1718483_516577598.0RepeatNote=TPR
HgeneCEP70chr3:138216872chr3:172227111ENST00000484888-1718483_516577598.0RepeatNote=TPR
HgeneCEP70chr3:138216872chr3:172227111ENST00000542237-1617483_516557578.0RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000264982-1718483_516577598.0RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000484888-1718483_516577598.0RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000542237-1617483_516557578.0RepeatNote=TPR
TgeneTNFSF10chr3:138216872chr3:172227111ENST00000420541031_170102.0Topological domainCytoplasmic
TgeneTNFSF10chr3:138216872chr3:172227111ENST000004205410339_2810102.0Topological domainExtracellular
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000420541031_170102.0Topological domainCytoplasmic
TgeneTNFSF10chr3:138216873chr3:172227111ENST000004205410339_2810102.0Topological domainExtracellular
TgeneTNFSF10chr3:138216872chr3:172227111ENST000004205410318_380102.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTNFSF10chr3:138216873chr3:172227111ENST000004205410318_380102.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP70chr3:138216872chr3:172227111ENST00000464035-16254_3260213.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000464035-1675_1790213.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000481834-116254_3260555.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000481834-11675_1790555.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000464035-16254_3260213.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000464035-1675_1790213.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000481834-116254_3260555.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216873chr3:172227111ENST00000481834-11675_1790555.0Coiled coilOntology_term=ECO:0000255
HgeneCEP70chr3:138216872chr3:172227111ENST00000464035-16483_5160213.0RepeatNote=TPR
HgeneCEP70chr3:138216872chr3:172227111ENST00000481834-116483_5160555.0RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000464035-16483_5160213.0RepeatNote=TPR
HgeneCEP70chr3:138216873chr3:172227111ENST00000481834-116483_5160555.0RepeatNote=TPR
TgeneTNFSF10chr3:138216872chr3:172227111ENST00000241261251_17104282.0Topological domainCytoplasmic
TgeneTNFSF10chr3:138216872chr3:172227111ENST000002412612539_281104282.0Topological domainExtracellular
TgeneTNFSF10chr3:138216873chr3:172227111ENST00000241261251_17104282.0Topological domainCytoplasmic
TgeneTNFSF10chr3:138216873chr3:172227111ENST000002412612539_281104282.0Topological domainExtracellular
TgeneTNFSF10chr3:138216872chr3:172227111ENST000002412612518_38104282.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTNFSF10chr3:138216873chr3:172227111ENST000002412612518_38104282.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for CEP70-TNFSF10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15888_15888_1_CEP70-TNFSF10_CEP70_chr3_138216872_ENST00000264982_TNFSF10_chr3_172227111_ENST00000241261_length(transcript)=3516nt_BP=1999nt
ATTCGCAGGCCAAAGAGGGGCTGGCCCTCGACGCGCTCGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGG
CCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACA
TGAGACTCGTTGGGTGATCATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGTAACTATG
TTTCCGGTAGCCCCTAAACCCCAGGATTCCAGTCAACCATCAGACAGACTCATGACTGAAAAACAGCAGGAAGAAGCAGAATGGGAAAGC
ATAAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAG
TCATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAAT
CAACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGT
GTGAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAG
AAAACTTTACAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGA
TTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGA
CAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAA
GAAGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCT
AAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAG
CAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAA
GATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAAT
CCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCAT
CTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTA
CCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTT
GAAAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCT
TTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAA
TTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATG
CAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAAT
GATCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGG
ACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGG
AGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACA
TACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGAC
CCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTT
GAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTT
TTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAA
AAATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATTCTACA
ACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTA
GCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAG
AAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAG
AGAAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAACCCAAGGTGGGTAGAT
CACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCAC
ATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCA
CTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAA
AATTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACTCACTTGTTTCATAATATCAAGATT
ACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTA

>15888_15888_1_CEP70-TNFSF10_CEP70_chr3_138216872_ENST00000264982_TNFSF10_chr3_172227111_ENST00000241261_length(amino acids)=754AA_BP=576
MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIET
NQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC
RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESK
SKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH
NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEE
VENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV
MQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESS
RSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGI

--------------------------------------------------------------
>15888_15888_2_CEP70-TNFSF10_CEP70_chr3_138216872_ENST00000489254_TNFSF10_chr3_172227111_ENST00000241261_length(transcript)=3009nt_BP=1492nt
CGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGGCCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCT
GGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGATCATTTCATTGAGATCAACC
TGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAA
ACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTG
TGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAA
AGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATG
TCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGG
CCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATT
AATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAG
GTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAAT
AAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTAT
AAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTG
TTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTT
TCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAAC
AATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGG
CTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAG
GAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGA
GGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTG
GGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCAT
GAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTC
CAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATAT
GGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGAC
ATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGT
TTTCAGGATGATACACTATGAAGATGTTTCAAAAAATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATC
TGAGTAGAGCAGCCACAACCAAAAAATTCTACAACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGA
TCTTTCAGGACTCTACCTCATATCAGTTTGCTAGCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCT
GTCTTTATAATCTACTCCTTGTAAAGACTGTAGAAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTT
TCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAGAAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAA
TCCCAACATTTTGGGAACCCAAGGTGGGTAGATCACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACT
GAAAGTACAAAAATTAGCTGGGTGTGTTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGG
AGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAA
ACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAATTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGT
TTTAGTACTCACTTGTTTCATAATATCAAGATTACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATAT

>15888_15888_2_CEP70-TNFSF10_CEP70_chr3_138216872_ENST00000489254_TNFSF10_chr3_172227111_ENST00000241261_length(amino acids)=602AA_BP=424
MTEVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEE
ENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKD
EPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVP
WLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLEL
DSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEKQQNISPLVRERGPQRVAAHITGT
RGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDP

--------------------------------------------------------------
>15888_15888_3_CEP70-TNFSF10_CEP70_chr3_138216872_ENST00000542237_TNFSF10_chr3_172227111_ENST00000241261_length(transcript)=3334nt_BP=1817nt
AGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGAT
CATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGCAGGAAGAAGCAGAATGGGAAAGCAT
AAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAGTC
ATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAATCA
ACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGTGT
GAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAGAA
AACTTTACAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATT
AAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACA
GTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGA
AGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAA
GATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCA
GGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGA
TGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCC
AAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCT
TGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACC
TTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGA
AAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTT
AAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATT
AGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCA
GGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGA
TCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGAC
CAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAG
TGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATA
CTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCC
TATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGA
GCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTT
AGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAAAA
ATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATTCTACAAC
ACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTAGC
AGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAGAA
GAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAG
AAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAACCCAAGGTGGGTAGATCA
CGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCACAT
GCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACT
ACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAA
TTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACTCACTTGTTTCATAATATCAAGATTAC
TAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTAAT

>15888_15888_3_CEP70-TNFSF10_CEP70_chr3_138216872_ENST00000542237_TNFSF10_chr3_172227111_ENST00000241261_length(amino acids)=734AA_BP=556
MTEQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ
RANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYL
CKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETR
PTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFN
KDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIV
SHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHE
EFFPAFQAFTNDLLEILEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIH
EKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLID

--------------------------------------------------------------
>15888_15888_4_CEP70-TNFSF10_CEP70_chr3_138216873_ENST00000264982_TNFSF10_chr3_172227111_ENST00000241261_length(transcript)=3516nt_BP=1999nt
ATTCGCAGGCCAAAGAGGGGCTGGCCCTCGACGCGCTCGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGG
CCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACA
TGAGACTCGTTGGGTGATCATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGTAACTATG
TTTCCGGTAGCCCCTAAACCCCAGGATTCCAGTCAACCATCAGACAGACTCATGACTGAAAAACAGCAGGAAGAAGCAGAATGGGAAAGC
ATAAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAG
TCATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAAT
CAACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGT
GTGAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAG
AAAACTTTACAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGA
TTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGA
CAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAA
GAAGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCT
AAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAG
CAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAA
GATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAAT
CCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCAT
CTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTA
CCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTT
GAAAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCT
TTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAA
TTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATG
CAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAAT
GATCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGG
ACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGG
AGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACA
TACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGAC
CCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTT
GAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTT
TTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAA
AAATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATTCTACA
ACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTA
GCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAG
AAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAG
AGAAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAACCCAAGGTGGGTAGAT
CACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCAC
ATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCA
CTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAA
AATTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACTCACTTGTTTCATAATATCAAGATT
ACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTA

>15888_15888_4_CEP70-TNFSF10_CEP70_chr3_138216873_ENST00000264982_TNFSF10_chr3_172227111_ENST00000241261_length(amino acids)=754AA_BP=576
MFPVAPKPQDSSQPSDRLMTEKQQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIET
NQQLRNELQLEQSRAANQEQRANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVC
RLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESK
SKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIH
NPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEE
VENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQV
MQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESS
RSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGI

--------------------------------------------------------------
>15888_15888_5_CEP70-TNFSF10_CEP70_chr3_138216873_ENST00000489254_TNFSF10_chr3_172227111_ENST00000241261_length(transcript)=3009nt_BP=1492nt
CGGGCTCGATTGGCCGCCCTCCCCCGGCGGTGGTAACGGTCGCGGAGGCGGGGCCTGACGTAGCTGATCCCAGCCTAACCTGGCCCGGCT
GGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGATCATTTCATTGAGATCAACC
TGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAA
ACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATTAAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTG
TGCAAAAGAGTTCCTCATACCGTCTTGGATAGACAGTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAA
AGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGAAGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATG
TCATTACAGAATCAACTCAAGGAATCAAAATCTAAGATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGG
CCTACGCAGCATGAATTAAGACTTTATAAACAGCAGGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATT
AATCATAAGAAGGCTGAGGACACAGAGAAGAAAGATGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAG
GTGCTGTGTAGCATCAATTCAATTATCCACAATCCAAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAAT
AAAGATCTTGTTCAAGATTGTGGATTTGAGCATCTTGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTAT
AAGTCCTTGAAAACACTATCTGCAGAACTGGTACCTTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTG
TTGTTTATAGTAGATACTATGCTGGAAGAAGTTGAAAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTT
TCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTTAAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAAC
AATGCTGTGAGAAACCTCCAAGAACTCTTAGAATTAGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGG
CTGATTAATGAAGATGTGAATGAGCAGGTTATGCAGGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAG
GAATTTTTCCCAGCATTTCAGGCATTTACTAATGATCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGA
GGTCCTCAGAGAGTAGCAGCTCACATAACTGGGACCAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTG
GGCCGCAAAATAAACTCCTGGGAATCATCAAGGAGTGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCAT
GAAAAAGGGTTTTACTACATCTATTCCCAAACATACTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTC
CAATATATTTACAAATACACAAGTTATCCTGACCCTATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATAT
GGACTCTATTCCATCTATCAAGGGGGAATATTTGAGCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGAC
ATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTTAGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGT
TTTCAGGATGATACACTATGAAGATGTTTCAAAAAATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATC
TGAGTAGAGCAGCCACAACCAAAAAATTCTACAACACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGA
TCTTTCAGGACTCTACCTCATATCAGTTTGCTAGCAGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCT
GTCTTTATAATCTACTCCTTGTAAAGACTGTAGAAGAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTT
TCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAGAAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAA
TCCCAACATTTTGGGAACCCAAGGTGGGTAGATCACGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACT
GAAAGTACAAAAATTAGCTGGGTGTGTTGGCACATGCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGG
AGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACTACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAA
ACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAATTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGT
TTTAGTACTCACTTGTTTCATAATATCAAGATTACTAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATAT

>15888_15888_5_CEP70-TNFSF10_CEP70_chr3_138216873_ENST00000489254_TNFSF10_chr3_172227111_ENST00000241261_length(amino acids)=602AA_BP=424
MTEVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYLCKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEE
ENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETRPTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKD
EPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFNKDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVP
WLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIVSHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLEL
DSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHEEFFPAFQAFTNDLLEILEKQQNISPLVRERGPQRVAAHITGT
RGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDP

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>15888_15888_6_CEP70-TNFSF10_CEP70_chr3_138216873_ENST00000542237_TNFSF10_chr3_172227111_ENST00000241261_length(transcript)=3334nt_BP=1817nt
AGCCTAACCTGGCCCGGCTGGCTGCTGGTGGGAGGCCGGCGACTGAGTAAGATGAAGATCCAGTTTCAGACATGAGACTCGTTGGGTGAT
CATTTCATTGAGATCAACCTGAATGACCAGGTGTAAAGTGCAAGAGTAATATGCTATGACTGAGCAGGAAGAAGCAGAATGGGAAAGCAT
AAATGTGCTATTGATGATGCATGGCTTAAAACCTTTGTCTCTAGTCAAAAGAACAGATCTCAAAGATCTCATCATTTTTGACAAACAGTC
ATCACAAAGGATGAGACAGAATTTGAAATTGTTGGTGGAAGAAACATCATGTCAACAGAACATGATACAGGAGCTTATAGAAACTAATCA
ACAGCTTAGAAATGAACTTCAGCTAGAGCAAAGCCGAGCAGCCAATCAAGAACAACGAGCTAATGACTTGGAACAAATTATGGAAAGTGT
GAAATCCAAAATTGGTGAATTGGAGGATGAATCACTAAGTAGGGCTTGCCACCAACAGAATAAAATAAAAGATCTTCAAAAGGAGCAGAA
AACTTTACAGGTGAAGTGCCAGCATTATAAGAAAAAACGAACGGAGCAAGAAGAAACTATTGCTTCTTTGCAAATGGAAGTCTGTAGATT
AAAAAAGGAGGAAGAAGATCGCATTGTCACTCAAAACAGAGTGTTTGCCTATCTGTGCAAAAGAGTTCCTCATACCGTCTTGGATAGACA
GTTGCTTTGTCTAATTGATTACTATGAATCTAAAATTAGAAAAATTCATACACAAAGGCAATATAAAGAAGATGAAAGTCAGTCAGAAGA
AGAAAACGACTACAGAAATCTGGATGCCTCACCAACTTATAAAGGCCTTTTAATGTCATTACAGAATCAACTCAAGGAATCAAAATCTAA
GATTGATGCACTTTCAAGTGAAAAGCTGAACCTCCAAAAAGATTTGGAAACCAGGCCTACGCAGCATGAATTAAGACTTTATAAACAGCA
GGTGAAGAAGCTGGAAAAAGCCCTTAAGAAAAACGTCAAATTACAGGAGCTTATTAATCATAAGAAGGCTGAGGACACAGAGAAGAAAGA
TGAGCCCAGCAAATATAATCAGCAACAGGCCCTAATTGACCAGAGATACTTTCAGGTGCTGTGTAGCATCAATTCAATTATCCACAATCC
AAGAGCTCCAGTAATAATTTATAAACAGACCAAAGGGGGAGTCCAAAATTTTAATAAAGATCTTGTTCAAGATTGTGGATTTGAGCATCT
TGTTCCTGTAATAGAAATGTGGGCAGATCAACTGACATCCTTAAAGGATTTGTATAAGTCCTTGAAAACACTATCTGCAGAACTGGTACC
TTGGCTTAATTTGAAGAAGCAGGATGAAAATGAAGGTATCAAAGTTGAAGATTTGTTGTTTATAGTAGATACTATGCTGGAAGAAGTTGA
AAATAAGGAAAAGGACAGCAATATGCCACACTTTCAAACTTTGCAAGCTATTGTTTCTCACTTCCAAAAGTTATTTGATGTGCCTTCTTT
AAATGGAGTCTATCCCCGAATGAATGAAGTTTATACTAGGCTTGGAGAAATGAACAATGCTGTGAGAAACCTCCAAGAACTCTTAGAATT
AGATAGTTCATCCTCATTGTGTGTGCTAGTAAGCACTGTTGGAAAACTCTGTAGGCTGATTAATGAAGATGTGAATGAGCAGGTTATGCA
GGTATTAGGACCTGAAGACCTCCAGAGCATTATCTACAAATTGGAAGAACACGAGGAATTTTTCCCAGCATTTCAGGCATTTACTAATGA
TCTACTTGAAATCTTAGAAAAGCAACAAAATATTTCTCCCCTAGTGAGAGAAAGAGGTCCTCAGAGAGTAGCAGCTCACATAACTGGGAC
CAGAGGAAGAAGCAACACATTGTCTTCTCCAAACTCCAAGAATGAAAAGGCTCTGGGCCGCAAAATAAACTCCTGGGAATCATCAAGGAG
TGGGCATTCATTCCTGAGCAACTTGCACTTGAGGAATGGTGAACTGGTCATCCATGAAAAAGGGTTTTACTACATCTATTCCCAAACATA
CTTTCGATTTCAGGAGGAAATAAAAGAAAACACAAAGAACGACAAACAAATGGTCCAATATATTTACAAATACACAAGTTATCCTGACCC
TATATTGTTGATGAAAAGTGCTAGAAATAGTTGTTGGTCTAAAGATGCAGAATATGGACTCTATTCCATCTATCAAGGGGGAATATTTGA
GCTTAAGGAAAATGACAGAATTTTTGTTTCTGTAACAAATGAGCACTTGATAGACATGGACCATGAAGCCAGTTTTTTTGGGGCCTTTTT
AGTTGGCTAACTGACCTGGAAAGAAAAAGCAATAACCTCAAAGTGACTATTCAGTTTTCAGGATGATACACTATGAAGATGTTTCAAAAA
ATCTGACCAAAACAAACAAACAGAAAACAGAAAACAAAAAAACCTCTATGCAATCTGAGTAGAGCAGCCACAACCAAAAAATTCTACAAC
ACACACTGTTCTGAAAGTGACTCACTTATCCCAAGAGAATGAAATTGCTGAAAGATCTTTCAGGACTCTACCTCATATCAGTTTGCTAGC
AGAAATCTAGAAGACTGTCAGCTTCCAAACATTAATGCAATGGTTAACATCTTCTGTCTTTATAATCTACTCCTTGTAAAGACTGTAGAA
GAAAGAGCAACAATCCATCTCTCAAGTAGTGTATCACAGTAGTAGCCTCCAGGTTTCCTTAAGGGACAACATCCTTAAGTCAAAAGAGAG
AAGAGGCACCACTAAAAGATCGCAGTTTGCCTGGTGCAGTGGCTCACACCTGTAATCCCAACATTTTGGGAACCCAAGGTGGGTAGATCA
CGAGATCAAGAGATCAAGACCATAGTGACCAACATAGTGAAACCCCATCTCTACTGAAAGTACAAAAATTAGCTGGGTGTGTTGGCACAT
GCCTGTAGTCCCAGCTACTTGAGAGGCTGAGGCAAGAGAATTGTTTGAACCCGGGAGGCAGAGGTTGCAGTGTGGTGAGATCATGCCACT
ACACTCCAGCCTGGCGACAGAGCGAGACTTGGTTTCAAAAAAAAAAAAAAAAAAAACTTCAGTAAGTACGTGTTATTTTTTTCAATAAAA
TTCTATTACAGTATGTCATGTTTGCTGTAGTGCTCATATTTATTGTTGTTTTTGTTTTAGTACTCACTTGTTTCATAATATCAAGATTAC
TAAAAATGGGGGAAAAGACTTCTAATCTTTTTTTCATAATATCTTTGACACATATTACAGAAGAAATAAATTTCTTACTTTTAATTTAAT

>15888_15888_6_CEP70-TNFSF10_CEP70_chr3_138216873_ENST00000542237_TNFSF10_chr3_172227111_ENST00000241261_length(amino acids)=734AA_BP=556
MTEQEEAEWESINVLLMMHGLKPLSLVKRTDLKDLIIFDKQSSQRMRQNLKLLVEETSCQQNMIQELIETNQQLRNELQLEQSRAANQEQ
RANDLEQIMESVKSKIGELEDESLSRACHQQNKIKDLQKEQKTLQVKCQHYKKKRTEQEETIASLQMEVCRLKKEEEDRIVTQNRVFAYL
CKRVPHTVLDRQLLCLIDYYESKIRKIHTQRQYKEDESQSEEENDYRNLDASPTYKGLLMSLQNQLKESKSKIDALSSEKLNLQKDLETR
PTQHELRLYKQQVKKLEKALKKNVKLQELINHKKAEDTEKKDEPSKYNQQQALIDQRYFQVLCSINSIIHNPRAPVIIYKQTKGGVQNFN
KDLVQDCGFEHLVPVIEMWADQLTSLKDLYKSLKTLSAELVPWLNLKKQDENEGIKVEDLLFIVDTMLEEVENKEKDSNMPHFQTLQAIV
SHFQKLFDVPSLNGVYPRMNEVYTRLGEMNNAVRNLQELLELDSSSSLCVLVSTVGKLCRLINEDVNEQVMQVLGPEDLQSIIYKLEEHE
EFFPAFQAFTNDLLEILEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIH
EKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLID

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Fusion Gene PPI Analysis for CEP70-TNFSF10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP70-TNFSF10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP70-TNFSF10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource