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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CEP85L-RUVBL2 (FusionGDB2 ID:15917)

Fusion Gene Summary for CEP85L-RUVBL2

check button Fusion gene summary
Fusion gene informationFusion gene name: CEP85L-RUVBL2
Fusion gene ID: 15917
HgeneTgene
Gene symbol

CEP85L

RUVBL2

Gene ID

387119

10856

Gene namecentrosomal protein 85 likeRuvB like AAA ATPase 2
SynonymsC6orf204|NY-BR-15|bA57K17.2CGI-46|ECP-51|ECP51|INO80J|REPTIN|RVB2|TAP54-beta|TIH2|TIP48|TIP49B
Cytomap

6q22.31

19q13.33

Type of geneprotein-codingprotein-coding
Descriptioncentrosomal protein of 85 kDa-likecentrosomal protein 85kDa-likeserologically defined breast cancer antigen NY-BR-15ruvB-like 248 kDa TATA box-binding protein-interacting protein48 kDa TBP-interacting protein51 kDa erythrocyte cytosolic proteinINO80 complex subunit JRuvB (E coli homolog)-like 2TIP60-associated protein 54-betaerythrocyte cytosolic protein, 51-KD
Modification date2020031320200327
UniProtAcc

Q5SZL2

.
Ensembl transtripts involved in fusion geneENST00000368488, ENST00000368491, 
ENST00000392500, ENST00000419517, 
ENST00000360290, ENST00000472713, 
ENST00000413176, ENST00000601968, 
ENST00000598768, ENST00000595090, 
Fusion gene scores* DoF score10 X 10 X 6=6006 X 7 X 6=252
# samples 117
** MAII scorelog2(11/600*10)=-2.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CEP85L [Title/Abstract] AND RUVBL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCEP85L(118953616)-RUVBL2(49506536), # samples:1
Anticipated loss of major functional domain due to fusion event.CEP85L-RUVBL2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CEP85L-RUVBL2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRUVBL2

GO:0043967

histone H4 acetylation

14966270

TgeneRUVBL2

GO:0043968

histone H2A acetylation

14966270

TgeneRUVBL2

GO:0090090

negative regulation of canonical Wnt signaling pathway

11080158


check buttonFusion gene breakpoints across CEP85L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RUVBL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5721-11ACEP85Lchr6

118953616

-RUVBL2chr19

49506536

+


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Fusion Gene ORF analysis for CEP85L-RUVBL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000368488ENST00000413176CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000368488ENST00000601968CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000368491ENST00000413176CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000368491ENST00000601968CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000392500ENST00000413176CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000392500ENST00000601968CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000419517ENST00000413176CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-5UTRENST00000419517ENST00000601968CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-intronENST00000368488ENST00000598768CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-intronENST00000368491ENST00000598768CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-intronENST00000392500ENST00000598768CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5CDS-intronENST00000419517ENST00000598768CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5UTR-3CDSENST00000360290ENST00000595090CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5UTR-5UTRENST00000360290ENST00000413176CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5UTR-5UTRENST00000360290ENST00000601968CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
5UTR-intronENST00000360290ENST00000598768CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
Frame-shiftENST00000368488ENST00000595090CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
Frame-shiftENST00000392500ENST00000595090CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
In-frameENST00000368491ENST00000595090CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
In-frameENST00000419517ENST00000595090CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
intron-3CDSENST00000472713ENST00000595090CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
intron-5UTRENST00000472713ENST00000413176CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
intron-5UTRENST00000472713ENST00000601968CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+
intron-intronENST00000472713ENST00000598768CEP85Lchr6

118953616

-RUVBL2chr19

49506536

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000368491CEP85Lchr6118953616-ENST00000595090RUVBL2chr1949506536+23328545112178555
ENST00000419517CEP85Lchr6118953616-ENST00000595090RUVBL2chr1949506536+22988204772144555

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000368491ENST00000595090CEP85Lchr6118953616-RUVBL2chr1949506536+0.0130569940.986943
ENST00000419517ENST00000595090CEP85Lchr6118953616-RUVBL2chr1949506536+0.0130334140.9869666

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Fusion Genomic Features for CEP85L-RUVBL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CEP85Lchr6118953615-RUVBL2chr1949506535+3.30E-070.99999964
CEP85Lchr6118953615-RUVBL2chr1949506535+3.30E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CEP85L-RUVBL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:118953616/chr19:49506536)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CEP85L

Q5SZL2

.
FUNCTION: Plays an essential role in neuronal cell migration. {ECO:0000269|PubMed:32097630}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRUVBL2chr6:118953616chr19:49506536ENST0000059509011577_8422464.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCEP85Lchr6:118953616chr19:49506536ENST00000360290-26439_6820395.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118953616chr19:49506536ENST00000368488-314439_68280809.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118953616chr19:49506536ENST00000368491-213439_68277806.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118953616chr19:49506536ENST00000392500-48439_68280500.0Coiled coilOntology_term=ECO:0000255
HgeneCEP85Lchr6:118953616chr19:49506536ENST00000419517-26439_68277497.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CEP85L-RUVBL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15917_15917_1_CEP85L-RUVBL2_CEP85L_chr6_118953616_ENST00000368491_RUVBL2_chr19_49506536_ENST00000595090_length(transcript)=2332nt_BP=854nt
GGGAGGGCGTGAGGGATTACCCAAGGGAGGGGCGAGTATCGCAAAATAGGCCAAGTCGCTGCCCTCTACTCAACTCGCAGGGCGGGAGGA
TGGAGACAGAGGGATGCGGCGGGAGGGCGGGACAGCCCAGTCGCCGCCAAGGAGGCGAAGCGGGGTCGGGGTAGCTCACCCGCCCCCCGC
AGTCCCCGCCCCCCGCAGTCCCCGCCCCGCGCGGCGCCGCGCACGCCTGAAGTCATTGCCCGAGGCCCCGCCCCCTCGCGGCCCCAGCCC
CGGCTCTGGCTCTGCCGGCGGAGGGGGCGGAGAGAACCCGCAGCTGCAACTTCGCCTGGAGCCTTTGAGCCTGGGCTCAGCCGGGGATCT
AGCAGCCGTCACCGCCGAGTCGCCGCTTCCCCGGCGCGGGCCTCAGCCCAGCCGGCTTGGCCATGGCAGGCGCCGGCAGTGCGGCGAATC
TGGCCCCTGCGCTCCCCGCCCGTAGCTGAGCAGCCGTTAACCAGCCATCCCGCCTTTCCTCCTGCCCGTGTCGCCGAGGCCCACGCTCCG
CGCAAGTTTCCGCCGCCGAAGAAGCAGGAGGACGGACGTGAGGAGTCGGGCGTCCCTGGCCCACCCGGCCCTCTCGCCCGCGATGTGGGG
GCGCTTCCTGGCTCCGGAGGCCAGCGGCCGGGATAGCCCCGGCGGAGCCCGCAGCTTCCCTGCCGGCCCAGATTATTCATCAGCATGGCT
ACCTGCTAATGAATCATTGTGGCAGGCCACAACTGTTCCATCTAACCATCGAAATAACCATATCAGGAGACACAGTATAGCTTCTGACAG
TGGAGACACTGGCATTGGAACTTCCTGTTCTGATAGCGTGGAAGGTGCCCACTCCCACATCCGGGGACTGGGGCTGGACGATGCCTTGGA
GCCTCGGCAGGCTTCGCAAGGCATGGTGGGTCAGCTGGCGGCACGGCGGGCGGCTGGCGTGGTGCTGGAGATGATCCGGGAAGGGAAGAT
TGCCGGTCGGGCAGTCCTTATTGCTGGCCAGCCGGGCACGGGGAAGACGGCCATCGCCATGGGCATGGCGCAGGCCCTGGGCCCTGACAC
GCCATTCACAGCCATCGCCGGCAGTGAAATCTTCTCCCTGGAGATGAGCAAGACCGAGGCGCTGACGCAGGCCTTCCGGCGGTCCATCGG
CGTTCGCATCAAGGAGGAGACGGAGATCATCGAAGGGGAGGTGGTGGAGATCCAGATTGATCGACCAGCAACAGGGACGGGCTCCAAGGT
GGGCAAACTGACCCTCAAGACCACAGAGATGGAGACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCA
GGCCGGGGACGTGATCACCATCGACAAGGCGACGGGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTAT
GGGCTCCCAGACCAAGTTCGTGCAGTGCCCAGATGGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGA
CGTCATCAACTCTCGCACCCAGGGCTTCCTGGCGCTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGC
CAAGGTGGCTGAGTGGCGCGAGGAGGGCAAGGCGGAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAG
CTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGACATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCAC
CAGCTACCAGAGCCCTCACGGCATCCCCATAGACCTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAA
GCAGATCCTCCGCATCCGGTGCGAGGAAGAAGATGTGGAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTC
ACTGCGCTACGCCATCCAGCTCATCACAGCTGCCAGCTTGGTGTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCG
GGTCTACTCACTCTTCCTGGACGAGTCCCGCTCCACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGA
GACCATGGACACCTCCTGAGTTGGATGTCATCCCCCGACCCCACCCTGTTTTCCACCAGAGTTCTGACACTGTGACTCTGTATAAAATGG

>15917_15917_1_CEP85L-RUVBL2_CEP85L_chr6_118953616_ENST00000368491_RUVBL2_chr19_49506536_ENST00000595090_length(amino acids)=555AA_BP=114
MPVSPRPTLRASFRRRRSRRTDVRSRASLAHPALSPAMWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNH
IRRHSIASDSGDTGIGTSCSDSVEGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAM
GMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKM
IESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEI
KSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVS
TTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQD

--------------------------------------------------------------
>15917_15917_2_CEP85L-RUVBL2_CEP85L_chr6_118953616_ENST00000419517_RUVBL2_chr19_49506536_ENST00000595090_length(transcript)=2298nt_BP=820nt
AGTATCGCAAAATAGGCCAAGTCGCTGCCCTCTACTCAACTCGCAGGGCGGGAGGATGGAGACAGAGGGATGCGGCGGGAGGGCGGGACA
GCCCAGTCGCCGCCAAGGAGGCGAAGCGGGGTCGGGGTAGCTCACCCGCCCCCCGCAGTCCCCGCCCCCCGCAGTCCCCGCCCCGCGCGG
CGCCGCGCACGCCTGAAGTCATTGCCCGAGGCCCCGCCCCCTCGCGGCCCCAGCCCCGGCTCTGGCTCTGCCGGCGGAGGGGGCGGAGAG
AACCCGCAGCTGCAACTTCGCCTGGAGCCTTTGAGCCTGGGCTCAGCCGGGGATCTAGCAGCCGTCACCGCCGAGTCGCCGCTTCCCCGG
CGCGGGCCTCAGCCCAGCCGGCTTGGCCATGGCAGGCGCCGGCAGTGCGGCGAATCTGGCCCCTGCGCTCCCCGCCCGTAGCTGAGCAGC
CGTTAACCAGCCATCCCGCCTTTCCTCCTGCCCGTGTCGCCGAGGCCCACGCTCCGCGCAAGTTTCCGCCGCCGAAGAAGCAGGAGGACG
GACGTGAGGAGTCGGGCGTCCCTGGCCCACCCGGCCCTCTCGCCCGCGATGTGGGGGCGCTTCCTGGCTCCGGAGGCCAGCGGCCGGGAT
AGCCCCGGCGGAGCCCGCAGCTTCCCTGCCGGCCCAGATTATTCATCAGCATGGCTACCTGCTAATGAATCATTGTGGCAGGCCACAACT
GTTCCATCTAACCATCGAAATAACCATATCAGGAGACACAGTATAGCTTCTGACAGTGGAGACACTGGCATTGGAACTTCCTGTTCTGAT
AGCGTGGAAGGTGCCCACTCCCACATCCGGGGACTGGGGCTGGACGATGCCTTGGAGCCTCGGCAGGCTTCGCAAGGCATGGTGGGTCAG
CTGGCGGCACGGCGGGCGGCTGGCGTGGTGCTGGAGATGATCCGGGAAGGGAAGATTGCCGGTCGGGCAGTCCTTATTGCTGGCCAGCCG
GGCACGGGGAAGACGGCCATCGCCATGGGCATGGCGCAGGCCCTGGGCCCTGACACGCCATTCACAGCCATCGCCGGCAGTGAAATCTTC
TCCCTGGAGATGAGCAAGACCGAGGCGCTGACGCAGGCCTTCCGGCGGTCCATCGGCGTTCGCATCAAGGAGGAGACGGAGATCATCGAA
GGGGAGGTGGTGGAGATCCAGATTGATCGACCAGCAACAGGGACGGGCTCCAAGGTGGGCAAACTGACCCTCAAGACCACAGAGATGGAG
ACCATCTACGACCTGGGCACCAAGATGATTGAGTCCCTGACCAAGGACAAGGTCCAGGCCGGGGACGTGATCACCATCGACAAGGCGACG
GGCAAGATCTCCAAGCTGGGCCGCTCCTTCACACGCGCCCGCGACTACGACGCTATGGGCTCCCAGACCAAGTTCGTGCAGTGCCCAGAT
GGGGAGCTCCAGAAACGCAAGGAGGTGGTGCACACCGTGTCCCTGCACGAGATCGACGTCATCAACTCTCGCACCCAGGGCTTCCTGGCG
CTCTTCTCAGGTGACACAGGGGAGATCAAGTCAGAAGTCCGTGAGCAGATCAATGCCAAGGTGGCTGAGTGGCGCGAGGAGGGCAAGGCG
GAGATCATCCCTGGAGTGCTGTTCATCGACGAGGTCCACATGCTGGACATCGAGAGCTTCTCCTTCCTCAACCGGGCCCTGGAGAGTGAC
ATGGCGCCTGTCCTGATCATGGCCACCAACCGTGGCATCACGCGAATCCGGGGCACCAGCTACCAGAGCCCTCACGGCATCCCCATAGAC
CTGCTGGACCGGCTGCTTATCGTCTCCACCACCCCCTACAGCGAGAAAGACACGAAGCAGATCCTCCGCATCCGGTGCGAGGAAGAAGAT
GTGGAGATGAGTGAGGACGCCTACACGGTGCTGACCCGCATCGGGCTGGAGACGTCACTGCGCTACGCCATCCAGCTCATCACAGCTGCC
AGCTTGGTGTGCCGGAAACGCAAGGGTACAGAAGTGCAGGTGGATGACATCAAGCGGGTCTACTCACTCTTCCTGGACGAGTCCCGCTCC
ACGCAGTACATGAAGGAGTACCAGGACGCCTTCCTCTTCAACGAACTCAAAGGCGAGACCATGGACACCTCCTGAGTTGGATGTCATCCC
CCGACCCCACCCTGTTTTCCACCAGAGTTCTGACACTGTGACTCTGTATAAAATGGTTGGGAAGCTGCACCCACCCTGTGTATGTGTGGT

>15917_15917_2_CEP85L-RUVBL2_CEP85L_chr6_118953616_ENST00000419517_RUVBL2_chr19_49506536_ENST00000595090_length(amino acids)=555AA_BP=114
MPVSPRPTLRASFRRRRSRRTDVRSRASLAHPALSPAMWGRFLAPEASGRDSPGGARSFPAGPDYSSAWLPANESLWQATTVPSNHRNNH
IRRHSIASDSGDTGIGTSCSDSVEGAHSHIRGLGLDDALEPRQASQGMVGQLAARRAAGVVLEMIREGKIAGRAVLIAGQPGTGKTAIAM
GMAQALGPDTPFTAIAGSEIFSLEMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRPATGTGSKVGKLTLKTTEMETIYDLGTKM
IESLTKDKVQAGDVITIDKATGKISKLGRSFTRARDYDAMGSQTKFVQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEI
KSEVREQINAKVAEWREEGKAEIIPGVLFIDEVHMLDIESFSFLNRALESDMAPVLIMATNRGITRIRGTSYQSPHGIPIDLLDRLLIVS
TTPYSEKDTKQILRIRCEEEDVEMSEDAYTVLTRIGLETSLRYAIQLITAASLVCRKRKGTEVQVDDIKRVYSLFLDESRSTQYMKEYQD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CEP85L-RUVBL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CEP85L-RUVBL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CEP85L-RUVBL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource