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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CERS2-GOLPH3L (FusionGDB2 ID:15973)

Fusion Gene Summary for CERS2-GOLPH3L

check button Fusion gene summary
Fusion gene informationFusion gene name: CERS2-GOLPH3L
Fusion gene ID: 15973
HgeneTgene
Gene symbol

CERS2

GOLPH3L

Gene ID

29956

55204

Gene nameceramide synthase 2golgi phosphoprotein 3 like
SynonymsL3|LASS2|SP260|TMSG1GPP34R
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionceramide synthase 2LAG1 homolog, ceramide synthase 2LAG1 longevity assurance 2longevity assurance (LAG1, S. cerevisiae) homolog 2sphingosine N-acyltransferase CERS2tumor metastasis-suppressor gene 1 proteinGolgi phosphoprotein 3-likeGPP34-related protein
Modification date2020032020200313
UniProtAcc

Q96G23

Q9H4A5

Ensembl transtripts involved in fusion geneENST00000271688, ENST00000368954, 
ENST00000561294, ENST00000345896, 
ENST00000479757, ENST00000271732, 
ENST00000540514, 
Fusion gene scores* DoF score4 X 6 X 5=1208 X 5 X 7=280
# samples 610
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CERS2 [Title/Abstract] AND GOLPH3L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCERS2(150941394)-GOLPH3L(150621224), # samples:2
Anticipated loss of major functional domain due to fusion event.CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CERS2-GOLPH3L seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERS2

GO:0046513

ceramide biosynthetic process

17977534|18165233|29632068


check buttonFusion gene breakpoints across CERS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GOLPH3L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-1667-01CCERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
ChimerDB4OVTCGA-09-1667-01CCERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
ChimerDB4OVTCGA-09-1667CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-


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Fusion Gene ORF analysis for CERS2-GOLPH3L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000271688ENST00000479757CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
5CDS-intronENST00000271688ENST00000479757CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
5CDS-intronENST00000368954ENST00000479757CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
5CDS-intronENST00000368954ENST00000479757CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
5CDS-intronENST00000561294ENST00000479757CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
5CDS-intronENST00000561294ENST00000479757CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
5UTR-3CDSENST00000271688ENST00000271732CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-3CDSENST00000271688ENST00000540514CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-3CDSENST00000345896ENST00000271732CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-3CDSENST00000345896ENST00000540514CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-3CDSENST00000368954ENST00000271732CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-3CDSENST00000368954ENST00000540514CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-intronENST00000271688ENST00000479757CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-intronENST00000345896ENST00000479757CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
5UTR-intronENST00000368954ENST00000479757CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000271688ENST00000271732CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000271688ENST00000271732CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000271688ENST00000540514CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000271688ENST00000540514CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000368954ENST00000540514CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000368954ENST00000540514CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000561294ENST00000271732CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
Frame-shiftENST00000561294ENST00000271732CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
In-frameENST00000368954ENST00000271732CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
In-frameENST00000368954ENST00000271732CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
In-frameENST00000561294ENST00000540514CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
In-frameENST00000561294ENST00000540514CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
intron-3CDSENST00000345896ENST00000271732CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
intron-3CDSENST00000345896ENST00000271732CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
intron-3CDSENST00000345896ENST00000540514CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
intron-3CDSENST00000345896ENST00000540514CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
intron-3CDSENST00000561294ENST00000271732CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
intron-3CDSENST00000561294ENST00000540514CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-
intron-intronENST00000345896ENST00000479757CERS2chr1

150941394

-GOLPH3Lchr1

150621224

-
intron-intronENST00000345896ENST00000479757CERS2chr1

150941393

-GOLPH3Lchr1

150621224

-
intron-intronENST00000561294ENST00000479757CERS2chr1

150947095

-GOLPH3Lchr1

150621224

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000561294CERS2chr1150941394-ENST00000540514GOLPH3Lchr1150621224-733195107622171
ENST00000368954CERS2chr1150941394-ENST00000271732GOLPH3Lchr1150621224-3083559471986171
ENST00000561294CERS2chr1150941393-ENST00000540514GOLPH3Lchr1150621224-733195107622171
ENST00000368954CERS2chr1150941393-ENST00000271732GOLPH3Lchr1150621224-3083559471986171

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000561294ENST00000540514CERS2chr1150941394-GOLPH3Lchr1150621224-0.0078745450.99212545
ENST00000368954ENST00000271732CERS2chr1150941394-GOLPH3Lchr1150621224-0.0041851290.99581486
ENST00000561294ENST00000540514CERS2chr1150941393-GOLPH3Lchr1150621224-0.0078745450.99212545
ENST00000368954ENST00000271732CERS2chr1150941393-GOLPH3Lchr1150621224-0.0041851290.99581486

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Fusion Genomic Features for CERS2-GOLPH3L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CERS2-GOLPH3L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150941394/chr1:150621224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CERS2

Q96G23

GOLPH3L

Q9H4A5

FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very-long (C22:0-C24:0) chain as acyl donor. May regulate lipid metabolism in hepatocytes (By similarity). {ECO:0000250|UniProtKB:Q924Z4, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:18165233, ECO:0000269|PubMed:18541923, ECO:0000269|PubMed:19728861, ECO:0000269|PubMed:20937905, ECO:0000269|PubMed:22144673, ECO:0000269|PubMed:22661289, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}.FUNCTION: Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane. {ECO:0000269|PubMed:23345592}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-2111_4057381.0Topological domainLumenal
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-2111_4057381.0Topological domainLumenal
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-2111_4057381.0Topological domainLumenal
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-2111_4057381.0Topological domainLumenal
TgeneGOLPH3Lchr1:150941393chr1:150621224ENST0000027173235176_187143286.0RegionBeta-hairpin required for oligomerization
TgeneGOLPH3Lchr1:150941394chr1:150621224ENST0000027173235176_187143286.0RegionBeta-hairpin required for oligomerization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211131_33257381.0DomainTLC
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211131_33257381.0DomainTLC
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211131_33257381.0DomainTLC
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211131_33257381.0DomainTLC
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211291_30057381.0MotifLast loop motif
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211291_30057381.0MotifLast loop motif
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211291_30057381.0MotifLast loop motif
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211291_30057381.0MotifLast loop motif
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-21167_12857381.0RegionHomeobox-like
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-21167_12857381.0RegionHomeobox-like
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-21167_12857381.0RegionHomeobox-like
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-21167_12857381.0RegionHomeobox-like
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211325_38057381.0Topological domainCytoplasmic
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211325_38057381.0Topological domainCytoplasmic
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211325_38057381.0Topological domainCytoplasmic
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211325_38057381.0Topological domainCytoplasmic
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211140_16057381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211181_20157381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211209_22957381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211264_28457381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-211304_32457381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000271688-21141_6157381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211140_16057381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211181_20157381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211209_22957381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211264_28457381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-211304_32457381.0TransmembraneHelical
HgeneCERS2chr1:150941393chr1:150621224ENST00000368954-21141_6157381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211140_16057381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211181_20157381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211209_22957381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211264_28457381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-211304_32457381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000271688-21141_6157381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211140_16057381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211181_20157381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211209_22957381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211264_28457381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-211304_32457381.0TransmembraneHelical
HgeneCERS2chr1:150941394chr1:150621224ENST00000368954-21141_6157381.0TransmembraneHelical


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Fusion Gene Sequence for CERS2-GOLPH3L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15973_15973_1_CERS2-GOLPH3L_CERS2_chr1_150941393_ENST00000368954_GOLPH3L_chr1_150621224_ENST00000271732_length(transcript)=3083nt_BP=559nt
AGCGCAAGGTGACGGGCGTGGACGCGGCTGTGGGGCCGGGAGCGGAGGGTTGGGGTCTGGCCTCCCGCGCCGGGGCGAAGGGGCAGCCGC
AGCGCAGAGGCCCGCCCCGCCCTCCCCTCCCGTCACGCCCAGCCTCCCGGCCCTTGGGCTGCTCGCGGCCTTTTTTTCCCGGCTGGGCTC
GGGCTCAGCTCGACTGGGCTCGGCGGGCGGCGGCGGCGGCGCCGGCGGCTGGCGGAGGAGGGAGGGCGAGGGCGGGCGCGGGCCGGCGGG
CGGGCGGAAGAGGGAGGAGAGGCGCGGGGAGCCAGGCCTCGGGGCCTCGGAGCAACCACCCGAGCAGACGGAGTACACGGAGCAGCGGCC
CCGGCCCCGCCAACGCTGCCGCCGGGATGCTCCAGACCTTGTATGATTACTTCTGGTGGGAACGTCTGTGGCTGCCTGTGAACTTGACCT
GGGCCGATCTAGAAGACCGAGATGGACGTGTCTACGCCAAAGCCTCAGATCTCTATATCACGCTGCCCCTGGCCTTGCTCTTCCTCATCG
TTCGATACTTCTTTGAGCTGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTA
GTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAG
CGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTG
CTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTA
GTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGC
CGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATT
TTTGTTTCCTTTTCTTGAATCAGACTTGTGATTTGGGGAGAGCAACTTCAGGGCTTCTCCATAGACCTTGACCATTATAAGCAGACCTTA
TTTCTCCCTACACTTCCACTCCATAGGTAAATAAACTGGGTGAAGCCACACACACCCAATGAACATTTTCTCCCATTTGGTGGTTTAGTT
TCACCCAGTGTGCTTTTGGATAAGCAGAAATATCTAAATGGGATTTTGAGTTCTCCAGCTATAGAATGTGAATGAGATAAAAAGTGAACT
ATCTATTATATTTTTCTGAGTTTGTTTTCTATCATAAATACATGTTTTCACAGCCTTTGTCTCTCAGACTCTGCTAAATAATGTAGCTTA
TTGAAATAACTGTCGCTGAATAAGGAGCAATGAGAAACAAAACTAATTTTTGGAGCAGATGGTCTCTGGAATTGCATATCCTGCTAGTGA
TTTTCTCATCTTTCCTTTTCTAACCTAATGAGAATGTCCCAGATTCAATTACCTGGATGTCAAAGTCCTAGAGCCAGAAATATATTCTCT
CATCCCTCTTAGCATTCTCTTGCTCCCTCATTCACTAGGGCAAATGTCTAAATGAAGAAAAGTCTCTCTCAACACCTCGTTCATGCAATC
AGCATTAGAATTTGTAAGGAAGGAAGGGGGGTGGCATGAAAATTTCCATTCTTGGGGTATATGACTGTCCTGTTTCCCCCAGGCCACTTT
TTTTTTTTTTTTCTTTTGAGACAGGGTCTTGCTCTTGCCCAGGCAGGAGTACAGTAGTGCAATCACAGCTGACTGCAGCCTTGACCTCCA
GGGCTCAAGGATCCTCCTGCCTCAGTCTCCCAACTAAGTGGGACTACAGGCACGTGCCACCATACTCAGCTTTTTTTTGTTTGTTTTAGA
CAAGAGTCTCGCTTTGTTGCCCAGGCTGGTCTTGAATTCCTGGGCTCAAGCAATTCTTCCACCTCAGCCTCCCAAAGTGCTGAGATTACT
GGCTTGAGCCACTGCACCCACCCCTCCAGACTACTTTAAATGTCTCTGCTCTGACTGAATTGAAGGAATTGTAAGTTTCAGTTGCTGAAT
ATATCAGTATATCTGAACTCCAGATCTTTTTATTTCCTATTTTTGGCTTCCTACATAAATTAATAAAGTCTGTCTATATTTAAGGTTTCT
GGGAGTAGTTTTGTCTATATTTAATCCATAGATGTGCTCCTAGTCATCAGTCTTATTTCAGTAAAACCATCTTTCTGGCCAAATCTCTAA
CACGTTTTTTACTTCAGTAGTGAGGGCAATGAGAAGCTTTATTAAGAAAGATCCTATTTAAAGGGCTAATTTGGTATTGAAAGCATGCTG
ATATAAAGTCCAGTATTTGAGGATATAAAGAGGATGTGCACTGAGCTGTGCTGATGTTCAGCATTTATTATACTTTAATGGGATAGTGCT
TCTTGACCATTATAGAACAACAAACTGTCAAAGGGTTAATACAGATGACCCAGACCTGACATTAAATCCTCTTGATTAGAAATAATTAAA
TGAATTATTTATTCATTTCTCTCCTCTGCCAAATCTACTTAGCCCCACAAAAATGCCCCAGCTCAGTTAACATTTTTTTGTTTTTCACTT
TAGGTATCTCTTAGGCAAATAGAGATATAAATTGTAATAGGAAACAGTCTCTAAATGTGAGGCTGAATACAGCTTCAGTCTGGCTCTCTA
ATAGGACAAAAGCCAGTCCATGTGTTGTCTCTAACTGATTTAGCTTTTTCTTTTCTTTGAACAATTCGGCATGAATTGAAACCAGGTTTT
CCTGTGGAAAGTTATAGCTTGATTGGGAGATAGAAGTTGAATTGAGTTCTTTCTTGCAACTCTTAGTGTTTATTTTTATATCTCAGTAAG
ACGAGGATACCTTCAGTTTGAATCTGCATAATGTTCACTGCCAAACTCCTTCTCATTTAATGCTTATGGCCTTCACATTTCTGTATAATA

>15973_15973_1_CERS2-GOLPH3L_CERS2_chr1_150941393_ENST00000368954_GOLPH3L_chr1_150621224_ENST00000271732_length(amino acids)=171AA_BP=0
MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ

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>15973_15973_2_CERS2-GOLPH3L_CERS2_chr1_150941393_ENST00000561294_GOLPH3L_chr1_150621224_ENST00000540514_length(transcript)=733nt_BP=195nt
TCCCCTTTGCCCCTCACTCAGGATGCTCCAGACCTTGTATGATTACTTCTGGTGGGAACGTCTGTGGCTGCCTGTGAACTTGACCTGGGC
CGATCTAGAAGACCGAGATGGACGTGTCTACGCCAAAGCCTCAGATCTCTATATCACGCTGCCCCTGGCCTTGCTCTTCCTCATCGTTCG
ATACTTCTTTGAGCTGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAGTAG
AGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGCGAC
TAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGCTAG
CCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAGTAG
AACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCCGGC
AGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATTTTTG

>15973_15973_2_CERS2-GOLPH3L_CERS2_chr1_150941393_ENST00000561294_GOLPH3L_chr1_150621224_ENST00000540514_length(amino acids)=171AA_BP=0
MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ

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>15973_15973_3_CERS2-GOLPH3L_CERS2_chr1_150941394_ENST00000368954_GOLPH3L_chr1_150621224_ENST00000271732_length(transcript)=3083nt_BP=559nt
AGCGCAAGGTGACGGGCGTGGACGCGGCTGTGGGGCCGGGAGCGGAGGGTTGGGGTCTGGCCTCCCGCGCCGGGGCGAAGGGGCAGCCGC
AGCGCAGAGGCCCGCCCCGCCCTCCCCTCCCGTCACGCCCAGCCTCCCGGCCCTTGGGCTGCTCGCGGCCTTTTTTTCCCGGCTGGGCTC
GGGCTCAGCTCGACTGGGCTCGGCGGGCGGCGGCGGCGGCGCCGGCGGCTGGCGGAGGAGGGAGGGCGAGGGCGGGCGCGGGCCGGCGGG
CGGGCGGAAGAGGGAGGAGAGGCGCGGGGAGCCAGGCCTCGGGGCCTCGGAGCAACCACCCGAGCAGACGGAGTACACGGAGCAGCGGCC
CCGGCCCCGCCAACGCTGCCGCCGGGATGCTCCAGACCTTGTATGATTACTTCTGGTGGGAACGTCTGTGGCTGCCTGTGAACTTGACCT
GGGCCGATCTAGAAGACCGAGATGGACGTGTCTACGCCAAAGCCTCAGATCTCTATATCACGCTGCCCCTGGCCTTGCTCTTCCTCATCG
TTCGATACTTCTTTGAGCTGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTA
GTAGAGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAG
CGACTAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTG
CTAGCCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTA
GTAGAACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGC
CGGCAGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATT
TTTGTTTCCTTTTCTTGAATCAGACTTGTGATTTGGGGAGAGCAACTTCAGGGCTTCTCCATAGACCTTGACCATTATAAGCAGACCTTA
TTTCTCCCTACACTTCCACTCCATAGGTAAATAAACTGGGTGAAGCCACACACACCCAATGAACATTTTCTCCCATTTGGTGGTTTAGTT
TCACCCAGTGTGCTTTTGGATAAGCAGAAATATCTAAATGGGATTTTGAGTTCTCCAGCTATAGAATGTGAATGAGATAAAAAGTGAACT
ATCTATTATATTTTTCTGAGTTTGTTTTCTATCATAAATACATGTTTTCACAGCCTTTGTCTCTCAGACTCTGCTAAATAATGTAGCTTA
TTGAAATAACTGTCGCTGAATAAGGAGCAATGAGAAACAAAACTAATTTTTGGAGCAGATGGTCTCTGGAATTGCATATCCTGCTAGTGA
TTTTCTCATCTTTCCTTTTCTAACCTAATGAGAATGTCCCAGATTCAATTACCTGGATGTCAAAGTCCTAGAGCCAGAAATATATTCTCT
CATCCCTCTTAGCATTCTCTTGCTCCCTCATTCACTAGGGCAAATGTCTAAATGAAGAAAAGTCTCTCTCAACACCTCGTTCATGCAATC
AGCATTAGAATTTGTAAGGAAGGAAGGGGGGTGGCATGAAAATTTCCATTCTTGGGGTATATGACTGTCCTGTTTCCCCCAGGCCACTTT
TTTTTTTTTTTTCTTTTGAGACAGGGTCTTGCTCTTGCCCAGGCAGGAGTACAGTAGTGCAATCACAGCTGACTGCAGCCTTGACCTCCA
GGGCTCAAGGATCCTCCTGCCTCAGTCTCCCAACTAAGTGGGACTACAGGCACGTGCCACCATACTCAGCTTTTTTTTGTTTGTTTTAGA
CAAGAGTCTCGCTTTGTTGCCCAGGCTGGTCTTGAATTCCTGGGCTCAAGCAATTCTTCCACCTCAGCCTCCCAAAGTGCTGAGATTACT
GGCTTGAGCCACTGCACCCACCCCTCCAGACTACTTTAAATGTCTCTGCTCTGACTGAATTGAAGGAATTGTAAGTTTCAGTTGCTGAAT
ATATCAGTATATCTGAACTCCAGATCTTTTTATTTCCTATTTTTGGCTTCCTACATAAATTAATAAAGTCTGTCTATATTTAAGGTTTCT
GGGAGTAGTTTTGTCTATATTTAATCCATAGATGTGCTCCTAGTCATCAGTCTTATTTCAGTAAAACCATCTTTCTGGCCAAATCTCTAA
CACGTTTTTTACTTCAGTAGTGAGGGCAATGAGAAGCTTTATTAAGAAAGATCCTATTTAAAGGGCTAATTTGGTATTGAAAGCATGCTG
ATATAAAGTCCAGTATTTGAGGATATAAAGAGGATGTGCACTGAGCTGTGCTGATGTTCAGCATTTATTATACTTTAATGGGATAGTGCT
TCTTGACCATTATAGAACAACAAACTGTCAAAGGGTTAATACAGATGACCCAGACCTGACATTAAATCCTCTTGATTAGAAATAATTAAA
TGAATTATTTATTCATTTCTCTCCTCTGCCAAATCTACTTAGCCCCACAAAAATGCCCCAGCTCAGTTAACATTTTTTTGTTTTTCACTT
TAGGTATCTCTTAGGCAAATAGAGATATAAATTGTAATAGGAAACAGTCTCTAAATGTGAGGCTGAATACAGCTTCAGTCTGGCTCTCTA
ATAGGACAAAAGCCAGTCCATGTGTTGTCTCTAACTGATTTAGCTTTTTCTTTTCTTTGAACAATTCGGCATGAATTGAAACCAGGTTTT
CCTGTGGAAAGTTATAGCTTGATTGGGAGATAGAAGTTGAATTGAGTTCTTTCTTGCAACTCTTAGTGTTTATTTTTATATCTCAGTAAG
ACGAGGATACCTTCAGTTTGAATCTGCATAATGTTCACTGCCAAACTCCTTCTCATTTAATGCTTATGGCCTTCACATTTCTGTATAATA

>15973_15973_3_CERS2-GOLPH3L_CERS2_chr1_150941394_ENST00000368954_GOLPH3L_chr1_150621224_ENST00000271732_length(amino acids)=171AA_BP=0
MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ

--------------------------------------------------------------
>15973_15973_4_CERS2-GOLPH3L_CERS2_chr1_150941394_ENST00000561294_GOLPH3L_chr1_150621224_ENST00000540514_length(transcript)=733nt_BP=195nt
TCCCCTTTGCCCCTCACTCAGGATGCTCCAGACCTTGTATGATTACTTCTGGTGGGAACGTCTGTGGCTGCCTGTGAACTTGACCTGGGC
CGATCTAGAAGACCGAGATGGACGTGTCTACGCCAAAGCCTCAGATCTCTATATCACGCTGCCCCTGGCCTTGCTCTTCCTCATCGTTCG
ATACTTCTTTGAGCTGTGAGACCTGGAACCCCTTCAAATTACAGTACCAGCTGAGAAATGTACGAGAGCGCATCGCAAAGAACCTAGTAG
AGAAAGGTATTCTAACCACTGAGAAGCAGAATTTCCTGCTATTTGACATGACTACTCATCCAGTGACCAATACAACAGAGAAACAGCGAC
TAGTGAAAAAACTTCAAGATAGTGTACTAGAGCGGTGGGTAAATGACCCTCAGCGTATGGACAAGCGAACACTAGCACTCCTGGTGCTAG
CCCACTCCTCTGATGTGCTAGAGAATGTCTTCTCCTCTCTGACAGATGACAAGTATGATGTGGCAATGAATCGAGCCAAGGACTTAGTAG
AACTGGACCCTGAAGTGGAAGGGACAAAGCCTAGTGCCACAGAAATGATCTGGGCTGTGCTGGCAGCCTTCAATAAATCTTAAAGCCGGC
AGGTGGATTTCTCCTTTTCCCCTGCTGGCTGGTGACTGTCAGAGACCCCATCACTGAGTTTTGTGTGATGAGATGTTTTCATCATTTTTG

>15973_15973_4_CERS2-GOLPH3L_CERS2_chr1_150941394_ENST00000561294_GOLPH3L_chr1_150621224_ENST00000540514_length(amino acids)=171AA_BP=0
MDVSTPKPQISISRCPWPCSSSSFDTSLSCETWNPFKLQYQLRNVRERIAKNLVEKGILTTEKQNFLLFDMTTHPVTNTTEKQRLVKKLQ

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Fusion Gene PPI Analysis for CERS2-GOLPH3L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CERS2-GOLPH3L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CERS2-GOLPH3L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource