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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CERS6-ABCB11 (FusionGDB2 ID:15992)

Fusion Gene Summary for CERS6-ABCB11

Fusion gene summary

Fusion gene information	Fusion gene name: CERS6-ABCB11
	Fusion gene ID: 15992
		Hgene	Tgene
	Gene symbol	CERS6	ABCB11
	Gene ID	253782	8647
	Gene name	ceramide synthase 6	ATP binding cassette subfamily B member 11
	Synonyms	CERS5\|LASS6	ABC16\|BRIC2\|BSEP\|PFIC-2\|PFIC2\|PGY4\|SPGP
	Cytomap	2q24.3	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	ceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6	bile salt export pumpABC member 16, MDR/TAP subfamilyATP-binding cassette sub-family B member 11ATP-binding cassette, sub-family B (MDR/TAP), member 11progressive familial intrahepatic cholestasis 2sister p-glycoprotein
	Modification date	20200313	20200313
	UniProtAcc	Q6ZMG9	O95342
	Ensembl transtripts involved in fusion gene	ENST00000305747, ENST00000392687,	ENST00000263817,
Fusion gene scores	* DoF score	18 X 12 X 8=1728	3 X 3 X 2=18
	# samples	22	3
	** MAII score	log2(22/1728*10)=-2.97352778863881 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CERS6 [Title/Abstract] AND ABCB11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CERS6(169487552)-ABCB11(169801471), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CERS6	GO:0046513	ceramide biosynthetic process	17609214\|17977534

Fusion gene breakpoints across CERS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ABCB11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8486-01A	CERS6	chr2	169487552	-	ABCB11	chr2	169801471	-
ChimerDB4	STAD	TCGA-BR-8486-01A	CERS6	chr2	169487552	+	ABCB11	chr2	169801471	-

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Fusion Gene ORF analysis for CERS6-ABCB11

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000305747	ENST00000263817	CERS6	chr2	169487552	+	ABCB11	chr2	169801471	-
In-frame	ENST00000392687	ENST00000263817	CERS6	chr2	169487552	+	ABCB11	chr2	169801471	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000305747

CERS6

chr2

169487552

ENST00000263817

ABCB11

chr2

169801471

3359

1052

287

2674

795

ENST00000392687

CERS6

chr2

169487552

ENST00000263817

ABCB11

chr2

169801471

2972

665

140

2287

715

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000305747	ENST00000263817	CERS6	chr2	169487552	+	ABCB11	chr2	169801471	-	0.004368013	0.99563205
ENST00000392687	ENST00000263817	CERS6	chr2	169487552	+	ABCB11	chr2	169801471	-	0.004397843	0.99560213

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Fusion Genomic Features for CERS6-ABCB11

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CERS6-ABCB11

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:169487552/chr2:169801471)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CERS6 Q6ZMG9	ABCB11 O95342
FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250\|UniProtKB:Q8C172, ECO:0000269\|PubMed:17609214, ECO:0000269\|PubMed:17977534, ECO:0000269\|PubMed:23530041, ECO:0000269\|PubMed:26887952, ECO:0000269\|PubMed:31916624}.	FUNCTION: Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner (PubMed:16332456, PubMed:22262466, PubMed:15791618, PubMed:18985798, PubMed:19228692, PubMed:20398791, PubMed:24711118, PubMed:29507376, PubMed:20010382, PubMed:32203132). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456). Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion (PubMed:15901796, PubMed:18245269). {ECO:0000269\|PubMed:15791618, ECO:0000269\|PubMed:15901796, ECO:0000269\|PubMed:16332456, ECO:0000269\|PubMed:18245269, ECO:0000269\|PubMed:18985798, ECO:0000269\|PubMed:19228692, ECO:0000269\|PubMed:20010382, ECO:0000269\|PubMed:20398791, ECO:0000269\|PubMed:22262466, ECO:0000269\|PubMed:24711118, ECO:0000269\|PubMed:29507376, ECO:0000269\|PubMed:32203132}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

66_127

155

385.0

Region

Homeobox-like

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

66_127

155

393.0

Region

Homeobox-like

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

1_34

155

385.0

Topological domain

Lumenal

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

1_34

155

393.0

Topological domain

Lumenal

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

35_55

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

35_55

155

393.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1078_1316

781

1322.0

Domain

ABC transporter 2

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1113_1120

781

1322.0

Nucleotide binding

ATP 2

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1311_1314

781

1322.0

Region

Mediates internalization from the plasma membrane

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1001_1011

781

1322.0

Topological domain

Extracellular

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1033_1321

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

816_869

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

912_979

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1012_1032

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

795_815

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

870_890

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

891_911

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

980_1000

781

1322.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

130_331

155

385.0

Domain

TLC

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

130_331

155

393.0

Domain

TLC

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

324_384

155

385.0

Topological domain

Cytoplasmic

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

324_384

155

393.0

Topological domain

Cytoplasmic

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

178_198

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

205_225

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

263_283

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000305747

303_323

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

178_198

155

393.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

205_225

155

393.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

263_283

155

393.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:169801471

ENST00000392687

303_323

155

393.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

420_656

781

1322.0

Domain

ABC transporter 1

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

62_385

781

1322.0

Domain

ABC transmembrane type-1 1

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

755_1043

781

1322.0

Domain

ABC transmembrane type-1 2

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

455_462

781

1322.0

Nucleotide binding

ATP 1

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

169_215

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

1_62

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

237_240

781

1322.0

Topological domain

Extracellular

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

262_319

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

341_353

781

1322.0

Topological domain

Extracellular

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

375_755

781

1322.0

Topological domain

Cytoplasmic

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

777_794

781

1322.0

Topological domain

Extracellular

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

84_147

781

1322.0

Topological domain

Extracellular

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

148_168

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

216_236

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

241_261

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

320_340

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

354_374

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

63_83

781

1322.0

Transmembrane

Helical

Tgene

ABCB11

chr2:169487552

chr2:169801471

ENST00000263817

756_776

781

1322.0

Transmembrane

Helical

Top

Fusion Gene Sequence for CERS6-ABCB11

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>15992_15992_1_CERS6-ABCB11_CERS6_chr2_169487552_ENST00000305747_ABCB11_chr2_169801471_ENST00000263817_length(transcript)=3359nt_BP=1052nt
AGGGCTGGTTCTGAAGCTTGGCGGCAGCCCCTACCTGCTGACCCACCGCCTCCGGGCGCACGGGAAGAGGACTGAGAGCCCTGAAACCCC
AGCGGGGCAGGAGCCAGCATTCTGAGCATGTGCGAGCCAGCCAGGGGGCTAGGGCGGATTTGGGGGGTCGACTTTAGGTCGTCGCCCTAA
GCGCAAAGCGAAAGAGCGGTGAGAGCAGGGGCGGGCGACACTCCCCGGAGCGGTGCCCCTGCGCCCAGGGCGCAGCGACTGCGCCCTGCC
CTGCGGGTGTGGGCGAGTTGGCCGCGTGTGTGCCTCGCTGTTTGACGCGAAGACGAGCCAATCAGGGCGGGCGGCCCGAGCTGCCATGTG
ACGGGCAAGGCGGCCCCTTTCCCCAGCGCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGG
AGGCGGCGGCGGCGGGCGGGAGCAGCGGCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAG
AGCTTGGCGGGCTGCGGGTGCCGCAGGACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGC
TCCCGCACAATGTCACCTGGGCGGACCTGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGG
CCTTCTGTATCTTCATGGTGCGGCTCATCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCAC
AAATTGCTCCGCCCAATGCCATTCTGGAAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGC
AACTGGACTGGGATGTTCGAAGCATTCAGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGA
GCATGTGGAGATTTTCATTTTACCTTTATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGACTTTTTCAATTCCTGATAAAGAGGAAC
AAAGGTCACAGATCAATGGTGTGTGCCTACTTTTTGTAGCAATGGGCTGTGTATCTCTTTTCACCCAATTTCTACAGGGATATGCCTTTG
CTAAATCTGGGGAGCTCCTAACAAAAAGGCTACGTAAATTTGGTTTCAGGGCAATGCTGGGGCAAGATATTGCCTGGTTTGATGACCTCA
GAAATAGCCCTGGAGCATTGACAACAAGACTTGCTACAGATGCTTCCCAAGTTCAAGGGGCTGCCGGCTCTCAGATCGGGATGATAGTCA
ATTCCTTCACTAACGTCACTGTGGCCATGATCATTGCCTTCTCCTTTAGCTGGAAGCTGAGCCTGGTCATCTTGTGCTTCTTCCCCTTCT
TGGCTTTATCAGGAGCCACACAGACCAGGATGTTGACAGGATTTGCCTCTCGAGATAAGCAGGCCCTGGAGATGGTGGGACAGATTACAA
ATGAAGCCCTCAGTAACATCCGCACTGTTGCTGGAATTGGAAAGGAGAGGCGGTTCATTGAAGCACTTGAGACTGAGCTGGAGAAGCCCT
TCAAGACAGCCATTCAGAAAGCCAATATTTACGGATTCTGCTTTGCCTTTGCCCAGTGCATCATGTTTATTGCGAATTCTGCTTCCTACA
GATATGGAGGTTACTTAATCTCCAATGAGGGGCTCCATTTCAGCTATGTGTTCAGGGTGATCTCTGCAGTTGTACTGAGTGCAACAGCTC
TTGGAAGAGCCTTCTCTTACACCCCAAGTTATGCAAAAGCTAAAATATCAGCTGCACGCTTTTTTCAACTGCTGGACCGACAACCCCCAA
TCAGTGTATACAATACTGCAGGTGAAAAATGGGACAACTTCCAGGGGAAGATTGATTTTGTTGATTGTAAATTTACATATCCTTCTCGAC
CTGACTCGCAAGTTCTGAATGGTCTCTCAGTGTCGATTAGTCCAGGGCAGACACTGGCGTTTGTTGGGAGCAGTGGATGTGGCAAAAGCA
CTAGCATTCAGCTGTTGGAACGTTTCTATGATCCTGATCAAGGGAAGGTGATGATAGATGGTCATGACAGCAAAAAAGTAAATGTCCAGT
TCCTCCGCTCAAACATTGGAATTGTTTCCCAGGAACCAGTGTTGTTTGCCTGTAGCATAATGGACAATATCAAGTATGGAGACAACACCA
AAGAAATTCCCATGGAAAGAGTCATAGCAGCTGCAAAACAGGCTCAGCTGCATGATTTTGTCATGTCACTCCCAGAGAAATATGAAACTA
ACGTTGGGTCCCAGGGGTCTCAACTCTCTAGAGGGGAGAAACAACGCATTGCTATTGCTCGGGCCATTGTACGAGATCCTAAAATCTTGC
TACTAGATGAAGCCACTTCTGCCTTAGACACAGAAAGTGAAAAGACGGTGCAGGTTGCTCTAGACAAAGCCAGAGAGGGTCGGACCTGCA
TTGTCATTGCCCATCGCTTGTCCACCATCCAGAACGCGGATATCATTGCTGTCATGGCACAGGGGGTGGTGATTGAAAAGGGGACCCATG
AAGAACTGATGGCCCAAAAAGGAGCCTACTACAAACTAGTCACCACTGGATCCCCCATCAGTTGACCCAATGCAAGAATCTCAGACACAC
ATGACGCACCAGTTACAGGGGTTGTTTTTAAAGAAAAAAACAATCCCAGCAGGAGGGATTGCTGGGATTGTTTTTTCTTTAAAGAAGAAT
GTTAATATTTTACTTTTACAGTCATTTTCCTACATCGGAATCCAAGCTAATTTCTAATGGCCTTCCATAATAATTCTGCTTTAGATGTGT
ATACAGAAAATGAAAGAAACTAGGGTCCATATGAGGGAAAACCCAATGTCAAGTGGCAGCTCAGCCACCACTCAGTGCTTCTCTGTGCAG
GAGCCAGTCCTGATTAATATGTGGGAATTAGTGAGACATCAGGGAGTAAGTGACACTTTGAACTCCTCAAGGGCAGAGAACTGTCTTTCA
TTTTTGAACCCTCGGTGTACACAGAGGCGGGTCTATAACAGGCAATCAACAAACGTTTCTTGAGCTAGACCAAGGTCAGATTTGAAAAGA
ACAGAAGGACTGAAGACCAGCTGTGTTTCTTAACTAAATTTGTCTTTCAAGTGAAACCAGCTTCCTTCATCTCTAAGGCTAAGGATAGGG
AAAGGGTGGATGCTCTCAGGCTGAGGGAGGCAGAAAGGGAAAGTATTAGCATGAGCTTTCCAGTTAGGGCTGTTGATTTATGCTTTAACT

>15992_15992_1_CERS6-ABCB11_CERS6_chr2_169487552_ENST00000305747_ABCB11_chr2_169801471_ENST00000263817_length(amino acids)=795AA_BP=252
MAACVPRCLTRRRANQGGRPELPCDGQGGPFPQRGQREERTGARREPSRAAAAEEAAAAGGSSGGGGTGSGPAGRASPGALRGGELGGLR
VPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPN
AILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTFSIPDKEEQRSQIN
GVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNV
TVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEKPFKTAIQ
KANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNT
AGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRSNI
GIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEAT

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>15992_15992_2_CERS6-ABCB11_CERS6_chr2_169487552_ENST00000392687_ABCB11_chr2_169801471_ENST00000263817_length(transcript)=2972nt_BP=665nt
GCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGGAGGCGGCGGCGGCGGGCGGGAGCAGCG
GCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAGAGCTTGGCGGGCTGCGGGTGCCGCAGG
ACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGCTCCCGCACAATGTCACCTGGGCGGACC
TGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGGCCTTCTGTATCTTCATGGTGCGGCTCA
TCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCACAAATTGCTCCGCCCAATGCCATTCTGG
AAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGCAACTGGACTGGGATGTTCGAAGCATTC
AGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGAGCATGTGGAGATTTTCATTTTACCTTT
ATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGACTTTTTCAATTCCTGATAAAGAGGAACAAAGGTCACAGATCAATGGTGTGTGCC
TACTTTTTGTAGCAATGGGCTGTGTATCTCTTTTCACCCAATTTCTACAGGGATATGCCTTTGCTAAATCTGGGGAGCTCCTAACAAAAA
GGCTACGTAAATTTGGTTTCAGGGCAATGCTGGGGCAAGATATTGCCTGGTTTGATGACCTCAGAAATAGCCCTGGAGCATTGACAACAA
GACTTGCTACAGATGCTTCCCAAGTTCAAGGGGCTGCCGGCTCTCAGATCGGGATGATAGTCAATTCCTTCACTAACGTCACTGTGGCCA
TGATCATTGCCTTCTCCTTTAGCTGGAAGCTGAGCCTGGTCATCTTGTGCTTCTTCCCCTTCTTGGCTTTATCAGGAGCCACACAGACCA
GGATGTTGACAGGATTTGCCTCTCGAGATAAGCAGGCCCTGGAGATGGTGGGACAGATTACAAATGAAGCCCTCAGTAACATCCGCACTG
TTGCTGGAATTGGAAAGGAGAGGCGGTTCATTGAAGCACTTGAGACTGAGCTGGAGAAGCCCTTCAAGACAGCCATTCAGAAAGCCAATA
TTTACGGATTCTGCTTTGCCTTTGCCCAGTGCATCATGTTTATTGCGAATTCTGCTTCCTACAGATATGGAGGTTACTTAATCTCCAATG
AGGGGCTCCATTTCAGCTATGTGTTCAGGGTGATCTCTGCAGTTGTACTGAGTGCAACAGCTCTTGGAAGAGCCTTCTCTTACACCCCAA
GTTATGCAAAAGCTAAAATATCAGCTGCACGCTTTTTTCAACTGCTGGACCGACAACCCCCAATCAGTGTATACAATACTGCAGGTGAAA
AATGGGACAACTTCCAGGGGAAGATTGATTTTGTTGATTGTAAATTTACATATCCTTCTCGACCTGACTCGCAAGTTCTGAATGGTCTCT
CAGTGTCGATTAGTCCAGGGCAGACACTGGCGTTTGTTGGGAGCAGTGGATGTGGCAAAAGCACTAGCATTCAGCTGTTGGAACGTTTCT
ATGATCCTGATCAAGGGAAGGTGATGATAGATGGTCATGACAGCAAAAAAGTAAATGTCCAGTTCCTCCGCTCAAACATTGGAATTGTTT
CCCAGGAACCAGTGTTGTTTGCCTGTAGCATAATGGACAATATCAAGTATGGAGACAACACCAAAGAAATTCCCATGGAAAGAGTCATAG
CAGCTGCAAAACAGGCTCAGCTGCATGATTTTGTCATGTCACTCCCAGAGAAATATGAAACTAACGTTGGGTCCCAGGGGTCTCAACTCT
CTAGAGGGGAGAAACAACGCATTGCTATTGCTCGGGCCATTGTACGAGATCCTAAAATCTTGCTACTAGATGAAGCCACTTCTGCCTTAG
ACACAGAAAGTGAAAAGACGGTGCAGGTTGCTCTAGACAAAGCCAGAGAGGGTCGGACCTGCATTGTCATTGCCCATCGCTTGTCCACCA
TCCAGAACGCGGATATCATTGCTGTCATGGCACAGGGGGTGGTGATTGAAAAGGGGACCCATGAAGAACTGATGGCCCAAAAAGGAGCCT
ACTACAAACTAGTCACCACTGGATCCCCCATCAGTTGACCCAATGCAAGAATCTCAGACACACATGACGCACCAGTTACAGGGGTTGTTT
TTAAAGAAAAAAACAATCCCAGCAGGAGGGATTGCTGGGATTGTTTTTTCTTTAAAGAAGAATGTTAATATTTTACTTTTACAGTCATTT
TCCTACATCGGAATCCAAGCTAATTTCTAATGGCCTTCCATAATAATTCTGCTTTAGATGTGTATACAGAAAATGAAAGAAACTAGGGTC
CATATGAGGGAAAACCCAATGTCAAGTGGCAGCTCAGCCACCACTCAGTGCTTCTCTGTGCAGGAGCCAGTCCTGATTAATATGTGGGAA
TTAGTGAGACATCAGGGAGTAAGTGACACTTTGAACTCCTCAAGGGCAGAGAACTGTCTTTCATTTTTGAACCCTCGGTGTACACAGAGG
CGGGTCTATAACAGGCAATCAACAAACGTTTCTTGAGCTAGACCAAGGTCAGATTTGAAAAGAACAGAAGGACTGAAGACCAGCTGTGTT
TCTTAACTAAATTTGTCTTTCAAGTGAAACCAGCTTCCTTCATCTCTAAGGCTAAGGATAGGGAAAGGGTGGATGCTCTCAGGCTGAGGG
AGGCAGAAAGGGAAAGTATTAGCATGAGCTTTCCAGTTAGGGCTGTTGATTTATGCTTTAACTTCAGAGTGAGTGTAGGGGTGGTGATGC

>15992_15992_2_CERS6-ABCB11_CERS6_chr2_169487552_ENST00000392687_ABCB11_chr2_169801471_ENST00000263817_length(amino acids)=715AA_BP=172
MRGGELGGLRVPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQ
ANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTFSIP
DKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQI
GMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETE
LEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLD
RQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKK
VNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRD

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Fusion Gene PPI Analysis for CERS6-ABCB11

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	ABCB11	chr2:169487552	chr2:169801471	ENST00000263817		18	28	651_672	781.0	1322.0	HAX1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CERS6-ABCB11

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CERS6-ABCB11

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source