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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CERS6-G6PC2 (FusionGDB2 ID:15999)

Fusion Gene Summary for CERS6-G6PC2

check button Fusion gene summary
Fusion gene informationFusion gene name: CERS6-G6PC2
Fusion gene ID: 15999
HgeneTgene
Gene symbol

CERS6

G6PC2

Gene ID

253782

57818

Gene nameceramide synthase 6glucose-6-phosphatase catalytic subunit 2
SynonymsCERS5|LASS6IGRP
Cytomap

2q24.3

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6glucose-6-phosphatase 2G-6-Pase 2G6Pase 2glucose-6-phosphatase, catalytic, 2islet-specific G6CP-related proteinislet-specific glucose-6-phosphatase catalytic subunit-related proteinislet-specific glucose-6-phosphatase-related protein
Modification date2020031320200313
UniProtAcc

Q6ZMG9

.
Ensembl transtripts involved in fusion geneENST00000305747, ENST00000392687, 
ENST00000461586, ENST00000375363, 
ENST00000421979, ENST00000429379, 
Fusion gene scores* DoF score18 X 12 X 8=17281 X 1 X 1=1
# samples 221
** MAII scorelog2(22/1728*10)=-2.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: CERS6 [Title/Abstract] AND G6PC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCERS6(169574488)-G6PC2(169764078), # samples:2
Anticipated loss of major functional domain due to fusion event.CERS6-G6PC2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CERS6-G6PC2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CERS6-G6PC2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERS6

GO:0046513

ceramide biosynthetic process

17609214|17977534


check buttonFusion gene breakpoints across CERS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across G6PC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-0940-01ACERS6chr2

169574488

+G6PC2chr2

169764078

+
ChimerDB4LUSCTCGA-22-0940CERS6chr2

169574488

+G6PC2chr2

169764078

+


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Fusion Gene ORF analysis for CERS6-G6PC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000305747ENST00000461586CERS6chr2

169574488

+G6PC2chr2

169764078

+
5CDS-3UTRENST00000392687ENST00000461586CERS6chr2

169574488

+G6PC2chr2

169764078

+
Frame-shiftENST00000305747ENST00000375363CERS6chr2

169574488

+G6PC2chr2

169764078

+
Frame-shiftENST00000392687ENST00000375363CERS6chr2

169574488

+G6PC2chr2

169764078

+
In-frameENST00000305747ENST00000421979CERS6chr2

169574488

+G6PC2chr2

169764078

+
In-frameENST00000305747ENST00000429379CERS6chr2

169574488

+G6PC2chr2

169764078

+
In-frameENST00000392687ENST00000421979CERS6chr2

169574488

+G6PC2chr2

169764078

+
In-frameENST00000392687ENST00000429379CERS6chr2

169574488

+G6PC2chr2

169764078

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305747CERS6chr2169574488+ENST00000429379G6PC2chr2169764078+159614322871456389
ENST00000305747CERS6chr2169574488+ENST00000421979G6PC2chr2169764078+170114322871456389
ENST00000392687CERS6chr2169574488+ENST00000429379G6PC2chr2169764078+120910451401069309
ENST00000392687CERS6chr2169574488+ENST00000421979G6PC2chr2169764078+131410451401069309

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305747ENST00000429379CERS6chr2169574488+G6PC2chr2169764078+0.029592590.97040737
ENST00000305747ENST00000421979CERS6chr2169574488+G6PC2chr2169764078+0.027078020.97292197
ENST00000392687ENST00000429379CERS6chr2169574488+G6PC2chr2169764078+0.013118030.9868819
ENST00000392687ENST00000421979CERS6chr2169574488+G6PC2chr2169764078+0.0146710850.985329

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Fusion Genomic Features for CERS6-G6PC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CERS6chr2169574488+G6PC2chr2169764077+9.07E-050.9999093
CERS6chr2169574488+G6PC2chr2169764077+9.07E-050.9999093
CERS6chr2169574488+G6PC2chr2169764077+9.07E-050.9999093
CERS6chr2169574488+G6PC2chr2169764077+9.07E-050.9999093

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CERS6-G6PC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:169574488/chr2:169764078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CERS6

Q6ZMG9

.
FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250|UniProtKB:Q8C172, ECO:0000269|PubMed:17609214, ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:31916624}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+81066_127281385.0RegionHomeobox-like
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+81166_127281393.0RegionHomeobox-like
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+8101_34281385.0Topological domainLumenal
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+8111_34281393.0Topological domainLumenal
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+810178_198281385.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+810205_225281385.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+810263_283281385.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+81035_55281385.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+811178_198281393.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+811205_225281393.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+811263_283281393.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+81135_55281393.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335352_355185356.0MotifPrevents secretion from ER
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924352_355146155.0MotifPrevents secretion from ER
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335190_211185356.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335233_261185356.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335283_293185356.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335315_318185356.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335340_355185356.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924190_211146155.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924233_261146155.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924283_293146155.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924315_318146155.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924340_355146155.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335212_232185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335262_282185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335294_314185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335319_339185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924147_167146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924169_189146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924212_232146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924262_282146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924294_314146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924319_339146155.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+810130_331281385.0DomainTLC
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+811130_331281393.0DomainTLC
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+810324_384281385.0Topological domainCytoplasmic
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+811324_384281393.0Topological domainCytoplasmic
HgeneCERS6chr2:169574488chr2:169764078ENST00000305747+810303_323281385.0TransmembraneHelical
HgeneCERS6chr2:169574488chr2:169764078ENST00000392687+811303_323281393.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335137_146185356.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST00000375363351_24185356.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST000003753633546_56185356.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST000003753633578_115185356.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924137_146146155.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST00000429379241_24146155.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST000004293792446_56146155.0Topological domainCytoplasmic
TgeneG6PC2chr2:169574488chr2:169764078ENST000004293792478_115146155.0Topological domainLumenal
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335116_136185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335147_167185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000037536335169_189185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST000003753633525_45185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST000003753633557_77185356.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST0000042937924116_136146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST000004293792425_45146155.0TransmembraneHelical
TgeneG6PC2chr2:169574488chr2:169764078ENST000004293792457_77146155.0TransmembraneHelical


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Fusion Gene Sequence for CERS6-G6PC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15999_15999_1_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000305747_G6PC2_chr2_169764078_ENST00000421979_length(transcript)=1701nt_BP=1432nt
AGGGCTGGTTCTGAAGCTTGGCGGCAGCCCCTACCTGCTGACCCACCGCCTCCGGGCGCACGGGAAGAGGACTGAGAGCCCTGAAACCCC
AGCGGGGCAGGAGCCAGCATTCTGAGCATGTGCGAGCCAGCCAGGGGGCTAGGGCGGATTTGGGGGGTCGACTTTAGGTCGTCGCCCTAA
GCGCAAAGCGAAAGAGCGGTGAGAGCAGGGGCGGGCGACACTCCCCGGAGCGGTGCCCCTGCGCCCAGGGCGCAGCGACTGCGCCCTGCC
CTGCGGGTGTGGGCGAGTTGGCCGCGTGTGTGCCTCGCTGTTTGACGCGAAGACGAGCCAATCAGGGCGGGCGGCCCGAGCTGCCATGTG
ACGGGCAAGGCGGCCCCTTTCCCCAGCGCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGG
AGGCGGCGGCGGCGGGCGGGAGCAGCGGCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAG
AGCTTGGCGGGCTGCGGGTGCCGCAGGACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGC
TCCCGCACAATGTCACCTGGGCGGACCTGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGG
CCTTCTGTATCTTCATGGTGCGGCTCATCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCAC
AAATTGCTCCGCCCAATGCCATTCTGGAAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGC
AACTGGACTGGGATGTTCGAAGCATTCAGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGA
GCATGTGGAGATTTTCATTTTACCTTTATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGACCCCCTGGTTGTGGAATACGAGGCATT
GCTGGTACAACTACCCCTATCAGCCACTCACAACTGACCTTCACTACTATTACATCCTGGAGCTGTCGTTTTATTGGTCTTTGATGTTTT
CTCAGTTCACTGATATCAAAAGAAAGGACTTTGGCATTATGTTCCTGCACCACCTTGTATCTATTTTCTTGATTACCTTTTCATATGTCA
ACAATATGGCCCGAGTAGGAACGCTGGTCCTTTGTCTTCATGATTCAGCTGATGCTCTTCTGGAGGCTGCCAAAATGGCAAATTATGCCA
AGTTTCAGAAAATGTGTGATCTCCTGTTTGTTATGTTTGCCGTGGTTTTTATCACCACACGACTGGGTATATTTCCTCTCTGGCATGCTG
GTGGCAGAGGCCTTTGAACACACTCCAGGCATCCAAACGGCCAGTCTGGGCACATACCTGAAGACCAACCTCTTTCTCTTCCTGTTTGCA
GTTGGCTTTTACCTGCTTCTTAGGGTGCTCAACATTGACCTGCTGTGGTCCGTGCCCATAGCCAAAAAGTGGTGTGCTAACCCCGACTGG

>15999_15999_1_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000305747_G6PC2_chr2_169764078_ENST00000421979_length(amino acids)=389AA_BP=1
MAACVPRCLTRRRANQGGRPELPCDGQGGPFPQRGQREERTGARREPSRAAAAEEAAAAGGSSGGGGTGSGPAGRASPGALRGGELGGLR
VPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPN
AILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYP
YQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMC

--------------------------------------------------------------
>15999_15999_2_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000305747_G6PC2_chr2_169764078_ENST00000429379_length(transcript)=1596nt_BP=1432nt
AGGGCTGGTTCTGAAGCTTGGCGGCAGCCCCTACCTGCTGACCCACCGCCTCCGGGCGCACGGGAAGAGGACTGAGAGCCCTGAAACCCC
AGCGGGGCAGGAGCCAGCATTCTGAGCATGTGCGAGCCAGCCAGGGGGCTAGGGCGGATTTGGGGGGTCGACTTTAGGTCGTCGCCCTAA
GCGCAAAGCGAAAGAGCGGTGAGAGCAGGGGCGGGCGACACTCCCCGGAGCGGTGCCCCTGCGCCCAGGGCGCAGCGACTGCGCCCTGCC
CTGCGGGTGTGGGCGAGTTGGCCGCGTGTGTGCCTCGCTGTTTGACGCGAAGACGAGCCAATCAGGGCGGGCGGCCCGAGCTGCCATGTG
ACGGGCAAGGCGGCCCCTTTCCCCAGCGCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGG
AGGCGGCGGCGGCGGGCGGGAGCAGCGGCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAG
AGCTTGGCGGGCTGCGGGTGCCGCAGGACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGC
TCCCGCACAATGTCACCTGGGCGGACCTGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGG
CCTTCTGTATCTTCATGGTGCGGCTCATCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCAC
AAATTGCTCCGCCCAATGCCATTCTGGAAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGC
AACTGGACTGGGATGTTCGAAGCATTCAGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGA
GCATGTGGAGATTTTCATTTTACCTTTATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGACCCCCTGGTTGTGGAATACGAGGCATT
GCTGGTACAACTACCCCTATCAGCCACTCACAACTGACCTTCACTACTATTACATCCTGGAGCTGTCGTTTTATTGGTCTTTGATGTTTT
CTCAGTTCACTGATATCAAAAGAAAGGACTTTGGCATTATGTTCCTGCACCACCTTGTATCTATTTTCTTGATTACCTTTTCATATGTCA
ACAATATGGCCCGAGTAGGAACGCTGGTCCTTTGTCTTCATGATTCAGCTGATGCTCTTCTGGAGGCTGCCAAAATGGCAAATTATGCCA
AGTTTCAGAAAATGTGTGATCTCCTGTTTGTTATGTTTGCCGTGGTTTTTATCACCACACGACTGGGTATATTTCCTCTCTGGCATGCTG
GTGGCAGAGGCCTTTGAACACACTCCAGGCATCCAAACGGCCAGTCTGGGCACATACCTGAAGACCAACCTCTTTCTCTTCCTGTTTGCA

>15999_15999_2_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000305747_G6PC2_chr2_169764078_ENST00000429379_length(amino acids)=389AA_BP=1
MAACVPRCLTRRRANQGGRPELPCDGQGGPFPQRGQREERTGARREPSRAAAAEEAAAAGGSSGGGGTGSGPAGRASPGALRGGELGGLR
VPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPN
AILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLWNTRHCWYNYP
YQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKMANYAKFQKMC

--------------------------------------------------------------
>15999_15999_3_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000392687_G6PC2_chr2_169764078_ENST00000421979_length(transcript)=1314nt_BP=1045nt
GCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGGAGGCGGCGGCGGCGGGCGGGAGCAGCG
GCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAGAGCTTGGCGGGCTGCGGGTGCCGCAGG
ACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGCTCCCGCACAATGTCACCTGGGCGGACC
TGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGGCCTTCTGTATCTTCATGGTGCGGCTCA
TCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCACAAATTGCTCCGCCCAATGCCATTCTGG
AAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGCAACTGGACTGGGATGTTCGAAGCATTC
AGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGAGCATGTGGAGATTTTCATTTTACCTTT
ATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGACCCCCTGGTTGTGGAATACGAGGCATTGCTGGTACAACTACCCCTATCAGCCAC
TCACAACTGACCTTCACTACTATTACATCCTGGAGCTGTCGTTTTATTGGTCTTTGATGTTTTCTCAGTTCACTGATATCAAAAGAAAGG
ACTTTGGCATTATGTTCCTGCACCACCTTGTATCTATTTTCTTGATTACCTTTTCATATGTCAACAATATGGCCCGAGTAGGAACGCTGG
TCCTTTGTCTTCATGATTCAGCTGATGCTCTTCTGGAGGCTGCCAAAATGGCAAATTATGCCAAGTTTCAGAAAATGTGTGATCTCCTGT
TTGTTATGTTTGCCGTGGTTTTTATCACCACACGACTGGGTATATTTCCTCTCTGGCATGCTGGTGGCAGAGGCCTTTGAACACACTCCA
GGCATCCAAACGGCCAGTCTGGGCACATACCTGAAGACCAACCTCTTTCTCTTCCTGTTTGCAGTTGGCTTTTACCTGCTTCTTAGGGTG
CTCAACATTGACCTGCTGTGGTCCGTGCCCATAGCCAAAAAGTGGTGTGCTAACCCCGACTGGATCCACATTGACACCACGCCTTTTGCT

>15999_15999_3_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000392687_G6PC2_chr2_169764078_ENST00000421979_length(amino acids)=309AA_BP=1
MRGGELGGLRVPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQ
ANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLW
NTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKM

--------------------------------------------------------------
>15999_15999_4_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000392687_G6PC2_chr2_169764078_ENST00000429379_length(transcript)=1209nt_BP=1045nt
GCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGGAGGCGGCGGCGGCGGGCGGGAGCAGCG
GCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAGAGCTTGGCGGGCTGCGGGTGCCGCAGG
ACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGCTCCCGCACAATGTCACCTGGGCGGACC
TGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGGCCTTCTGTATCTTCATGGTGCGGCTCA
TCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCACAAATTGCTCCGCCCAATGCCATTCTGG
AAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGCAACTGGACTGGGATGTTCGAAGCATTC
AGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGAGCATGTGGAGATTTTCATTTTACCTTT
ATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGACCCCCTGGTTGTGGAATACGAGGCATTGCTGGTACAACTACCCCTATCAGCCAC
TCACAACTGACCTTCACTACTATTACATCCTGGAGCTGTCGTTTTATTGGTCTTTGATGTTTTCTCAGTTCACTGATATCAAAAGAAAGG
ACTTTGGCATTATGTTCCTGCACCACCTTGTATCTATTTTCTTGATTACCTTTTCATATGTCAACAATATGGCCCGAGTAGGAACGCTGG
TCCTTTGTCTTCATGATTCAGCTGATGCTCTTCTGGAGGCTGCCAAAATGGCAAATTATGCCAAGTTTCAGAAAATGTGTGATCTCCTGT
TTGTTATGTTTGCCGTGGTTTTTATCACCACACGACTGGGTATATTTCCTCTCTGGCATGCTGGTGGCAGAGGCCTTTGAACACACTCCA
GGCATCCAAACGGCCAGTCTGGGCACATACCTGAAGACCAACCTCTTTCTCTTCCTGTTTGCAGTTGGCTTTTACCTGCTTCTTAGGGTG

>15999_15999_4_CERS6-G6PC2_CERS6_chr2_169574488_ENST00000392687_G6PC2_chr2_169764078_ENST00000429379_length(amino acids)=309AA_BP=1
MRGGELGGLRVPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQ
ANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKTPWLW
NTRHCWYNYPYQPLTTDLHYYYILELSFYWSLMFSQFTDIKRKDFGIMFLHHLVSIFLITFSYVNNMARVGTLVLCLHDSADALLEAAKM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CERS6-G6PC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CERS6-G6PC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CERS6-G6PC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource