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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CERS6-GAD1 (FusionGDB2 ID:16000)

Fusion Gene Summary for CERS6-GAD1

Fusion gene summary

Fusion gene information	Fusion gene name: CERS6-GAD1
	Fusion gene ID: 16000
		Hgene	Tgene
	Gene symbol	CERS6	GAD1
	Gene ID	253782	2571
	Gene name	ceramide synthase 6	glutamate decarboxylase 1
	Synonyms	CERS5\|LASS6	CPSQ1\|GAD\|SCP
	Cytomap	2q24.3	2q31.1
	Type of gene	protein-coding	protein-coding
	Description	ceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6	glutamate decarboxylase 167 kDa glutamic acid decarboxylaseGAD-67glutamate decarboxylase 1 (brain, 67kDa)glutamate decarboxylase 67 kDa isoform
	Modification date	20200313	20200315
	UniProtAcc	Q6ZMG9	Q99259
	Ensembl transtripts involved in fusion gene	ENST00000305747, ENST00000392687,	ENST00000344257, ENST00000375272, ENST00000429023, ENST00000358196,
Fusion gene scores	* DoF score	18 X 12 X 8=1728	3 X 4 X 3=36
	# samples	22	3
	** MAII score	log2(22/1728*10)=-2.97352778863881 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CERS6 [Title/Abstract] AND GAD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CERS6(169487552)-GAD1(171715314), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CERS6	GO:0046513	ceramide biosynthetic process	17609214\|17977534

Fusion gene breakpoints across CERS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GAD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-XR-A8TG-01A	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+

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Fusion Gene ORF analysis for CERS6-GAD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000305747	ENST00000344257	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
5CDS-intron	ENST00000305747	ENST00000375272	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
5CDS-intron	ENST00000305747	ENST00000429023	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
5CDS-intron	ENST00000392687	ENST00000344257	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
5CDS-intron	ENST00000392687	ENST00000375272	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
5CDS-intron	ENST00000392687	ENST00000429023	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
In-frame	ENST00000305747	ENST00000358196	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+
In-frame	ENST00000392687	ENST00000358196	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000305747

CERS6

chr2

169487552

ENST00000358196

GAD1

chr2

171715314

2585

1052

287

1315

342

ENST00000392687

CERS6

chr2

169487552

ENST00000358196

GAD1

chr2

171715314

2198

665

140

928

262

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000305747	ENST00000358196	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+	0.00359103	0.996409
ENST00000392687	ENST00000358196	CERS6	chr2	169487552	-	GAD1	chr2	171715314	+	0.001711747	0.9982882

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Fusion Genomic Features for CERS6-GAD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CERS6-GAD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:169487552/chr2:171715314)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CERS6 Q6ZMG9	GAD1 Q99259
FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624). Can use other acyl donors, but with less efficiency (By similarity). Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). {ECO:0000250\|UniProtKB:Q8C172, ECO:0000269\|PubMed:17609214, ECO:0000269\|PubMed:17977534, ECO:0000269\|PubMed:23530041, ECO:0000269\|PubMed:26887952, ECO:0000269\|PubMed:31916624}.	FUNCTION: Catalyzes the production of GABA.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

66_127

155

385.0

Region

Homeobox-like

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

66_127

155

393.0

Region

Homeobox-like

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

1_34

155

385.0

Topological domain

Lumenal

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

1_34

155

393.0

Topological domain

Lumenal

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

35_55

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

35_55

155

393.0

Transmembrane

Helical

Tgene

GAD1

chr2:169487552

chr2:171715314

ENST00000344257

190_192

225.0

Region

Note=Substrate binding

Tgene

GAD1

chr2:169487552

chr2:171715314

ENST00000375272

190_192

225.0

Region

Note=Substrate binding

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

130_331

155

385.0

Domain

TLC

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

130_331

155

393.0

Domain

TLC

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

324_384

155

385.0

Topological domain

Cytoplasmic

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

324_384

155

393.0

Topological domain

Cytoplasmic

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

178_198

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

205_225

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

263_283

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000305747

303_323

155

385.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

178_198

155

393.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

205_225

155

393.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

263_283

155

393.0

Transmembrane

Helical

Hgene

CERS6

chr2:169487552

chr2:171715314

ENST00000392687

303_323

155

393.0

Transmembrane

Helical

Tgene

GAD1

chr2:169487552

chr2:171715314

ENST00000358196

190_192

507

595.0

Region

Note=Substrate binding

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Fusion Gene Sequence for CERS6-GAD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16000_16000_1_CERS6-GAD1_CERS6_chr2_169487552_ENST00000305747_GAD1_chr2_171715314_ENST00000358196_length(transcript)=2585nt_BP=1052nt
AGGGCTGGTTCTGAAGCTTGGCGGCAGCCCCTACCTGCTGACCCACCGCCTCCGGGCGCACGGGAAGAGGACTGAGAGCCCTGAAACCCC
AGCGGGGCAGGAGCCAGCATTCTGAGCATGTGCGAGCCAGCCAGGGGGCTAGGGCGGATTTGGGGGGTCGACTTTAGGTCGTCGCCCTAA
GCGCAAAGCGAAAGAGCGGTGAGAGCAGGGGCGGGCGACACTCCCCGGAGCGGTGCCCCTGCGCCCAGGGCGCAGCGACTGCGCCCTGCC
CTGCGGGTGTGGGCGAGTTGGCCGCGTGTGTGCCTCGCTGTTTGACGCGAAGACGAGCCAATCAGGGCGGGCGGCCCGAGCTGCCATGTG
ACGGGCAAGGCGGCCCCTTTCCCCAGCGCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGG
AGGCGGCGGCGGCGGGCGGGAGCAGCGGCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAG
AGCTTGGCGGGCTGCGGGTGCCGCAGGACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGC
TCCCGCACAATGTCACCTGGGCGGACCTGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGG
CCTTCTGTATCTTCATGGTGCGGCTCATCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCAC
AAATTGCTCCGCCCAATGCCATTCTGGAAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGC
AACTGGACTGGGATGTTCGAAGCATTCAGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGA
GCATGTGGAGATTTTCATTTTACCTTTATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGCCTGAGCACACAAACGTCTGTTTTTGGT
ATATTCCACAAAGCCTCAGGGGTGTGCCAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCAAAAATCAAAGCCCTGATGA
TGGAGTCAGGTACGACCATGGTTGGCTACCAGCCCCAAGGGGACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCC
AGTCTGACATTGACTTCCTCATTGAGGAGATAGAAAGACTGGGCCAGGATCTGTAATCATCCTTCGCAGAACATGAGTTTATGGGAATGC
CTTTTCCCTCTGGCACTCCAGAACAAACCTCTATATGTTGCTGAAACACACAGGCCATTTCATTGAGGGAAAACATAATATCTTGAAGAA
TATTGTTAAAACCTTACTTAAAGCTTGTTTGTTCTAGTTAGCAGGAAATAGTGTTCTTTTTAAAAAGTTGCACATTAGGAACAGAGTATA
TATGTACAGTTATACATACCTCTCTCTATATATACATGTATAGTGAGTGTGGCTTAGTAATAGATCACGGCATGTTTCCCGCTCCAAGAG
AATTCACTTTACCTTCAGCAGTTACCGAGGAGCTAAACATGCTGCCAACCAGCTTGTCCAACAACTCCAGGAAAACTGTTTTTCAAAACG
CCATGTCCTAGGGGCCGAGGGAAATGCTGTTGGTGAGAATCGACCTCACTGTCAGCGTTTCTCCACCTGAAGTGATGATGGATGAGAAAA
AACACCACCAAATGACAAGTCACACCCTCCCCATTAGTATCCTGTTAGGGGAAAATAGTAGCAGAGTCATTGTTACAGGTGTACTATGGC
TGTATTTTTAGAGATTAATTTGTGTAGATTGTGTAAATTCCTGTTGTCTGACCTTGGTGGTGGGAGGGGGAGACTATGTGTCATGATTTC
AATGATTGTTTAATTGTAGGTCAATGAAATATTTGCTTATTTATATTCAGAGATGTACCATGTTAAAGAGGCGTCTTGTATTTTCTTCCC
ATTTGTAATGTATCTTATTTATATATGAAGTAAGTTCTGAAAACTGTTTATGGTATTTTCGTGCATTTGTGAGCCAAAGAGAAAAGATTA
AAATTAGTGAGATTTGTATTTATATTAGAGTGCCCTTAAAATAATGATTTAAGCATTTTACTGTCTGTAAGAGAATTCTAAGATTGTACA
TAAAGTCATATATATGGAAATCCTGTTACTTAAATAGCATCTGCTCTTCTCTTACGCTCTCTGTCTGGCTGTACGTCTGGTGTTCTCAAT
GCTTTTCTAGCAACTGTTGGATAATAACTAGATCTCCTGTAATTTTGTAGTAGTTGATGACCAATCTCTGTGACTCGCTTAGCTGAAACC
TAAGGCAACATTTCCGAAGACCTTCTGAAGATCTCAGATAAAGTGACCAGGCTCACAACTGTTTTTGAAGAAGGGAAATTCACACTGTGC

>16000_16000_1_CERS6-GAD1_CERS6_chr2_169487552_ENST00000305747_GAD1_chr2_171715314_ENST00000358196_length(amino acids)=342AA_BP=255
MAACVPRCLTRRRANQGGRPELPCDGQGGPFPQRGQREERTGARREPSRAAAAEEAAAAGGSSGGGGTGSGPAGRASPGALRGGELGGLR
VPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPN
AILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKPEHTNVCFWYIPQSL

--------------------------------------------------------------
>16000_16000_2_CERS6-GAD1_CERS6_chr2_169487552_ENST00000392687_GAD1_chr2_171715314_ENST00000358196_length(transcript)=2198nt_BP=665nt
GCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGGAGGCGGCGGCGGCGGGCGGGAGCAGCG
GCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAGAGCTTGGCGGGCTGCGGGTGCCGCAGG
ACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGCTCCCGCACAATGTCACCTGGGCGGACC
TGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGGCCTTCTGTATCTTCATGGTGCGGCTCA
TCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCACAAATTGCTCCGCCCAATGCCATTCTGG
AAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGCAACTGGACTGGGATGTTCGAAGCATTC
AGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGAGCATGTGGAGATTTTCATTTTACCTTT
ATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGCCTGAGCACACAAACGTCTGTTTTTGGTATATTCCACAAAGCCTCAGGGGTGTGC
CAGACAGCCCTCAACGACGGGAAAAGCTACACAAGGTGGCTCCAAAAATCAAAGCCCTGATGATGGAGTCAGGTACGACCATGGTTGGCT
ACCAGCCCCAAGGGGACAAGGCCAACTTCTTCCGGATGGTCATCTCCAACCCAGCCGCTACCCAGTCTGACATTGACTTCCTCATTGAGG
AGATAGAAAGACTGGGCCAGGATCTGTAATCATCCTTCGCAGAACATGAGTTTATGGGAATGCCTTTTCCCTCTGGCACTCCAGAACAAA
CCTCTATATGTTGCTGAAACACACAGGCCATTTCATTGAGGGAAAACATAATATCTTGAAGAATATTGTTAAAACCTTACTTAAAGCTTG
TTTGTTCTAGTTAGCAGGAAATAGTGTTCTTTTTAAAAAGTTGCACATTAGGAACAGAGTATATATGTACAGTTATACATACCTCTCTCT
ATATATACATGTATAGTGAGTGTGGCTTAGTAATAGATCACGGCATGTTTCCCGCTCCAAGAGAATTCACTTTACCTTCAGCAGTTACCG
AGGAGCTAAACATGCTGCCAACCAGCTTGTCCAACAACTCCAGGAAAACTGTTTTTCAAAACGCCATGTCCTAGGGGCCGAGGGAAATGC
TGTTGGTGAGAATCGACCTCACTGTCAGCGTTTCTCCACCTGAAGTGATGATGGATGAGAAAAAACACCACCAAATGACAAGTCACACCC
TCCCCATTAGTATCCTGTTAGGGGAAAATAGTAGCAGAGTCATTGTTACAGGTGTACTATGGCTGTATTTTTAGAGATTAATTTGTGTAG
ATTGTGTAAATTCCTGTTGTCTGACCTTGGTGGTGGGAGGGGGAGACTATGTGTCATGATTTCAATGATTGTTTAATTGTAGGTCAATGA
AATATTTGCTTATTTATATTCAGAGATGTACCATGTTAAAGAGGCGTCTTGTATTTTCTTCCCATTTGTAATGTATCTTATTTATATATG
AAGTAAGTTCTGAAAACTGTTTATGGTATTTTCGTGCATTTGTGAGCCAAAGAGAAAAGATTAAAATTAGTGAGATTTGTATTTATATTA
GAGTGCCCTTAAAATAATGATTTAAGCATTTTACTGTCTGTAAGAGAATTCTAAGATTGTACATAAAGTCATATATATGGAAATCCTGTT
ACTTAAATAGCATCTGCTCTTCTCTTACGCTCTCTGTCTGGCTGTACGTCTGGTGTTCTCAATGCTTTTCTAGCAACTGTTGGATAATAA
CTAGATCTCCTGTAATTTTGTAGTAGTTGATGACCAATCTCTGTGACTCGCTTAGCTGAAACCTAAGGCAACATTTCCGAAGACCTTCTG
AAGATCTCAGATAAAGTGACCAGGCTCACAACTGTTTTTGAAGAAGGGAAATTCACACTGTGCGTTTTAGAGTATGCAAGAAGAATATAA

>16000_16000_2_CERS6-GAD1_CERS6_chr2_169487552_ENST00000392687_GAD1_chr2_171715314_ENST00000358196_length(amino acids)=262AA_BP=175
MRGGELGGLRVPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQ
ANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKPEHTN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CERS6-GAD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CERS6-GAD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CERS6-GAD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source