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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CFLAR-NDUFB3 (FusionGDB2 ID:16146)

Fusion Gene Summary for CFLAR-NDUFB3

check button Fusion gene summary
Fusion gene informationFusion gene name: CFLAR-NDUFB3
Fusion gene ID: 16146
HgeneTgene
Gene symbol

CFLAR

NDUFB3

Gene ID

8837

4709

Gene nameCASP8 and FADD like apoptosis regulatorNADH:ubiquinone oxidoreductase subunit B3
SynonymsCASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS|cFLIPB12|CI-B12|MC1DN25
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
DescriptionCASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like inNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDaNADH-ubiquinone oxidoreductase B12 subunitcomplex I-B12
Modification date2020032220200313
UniProtAcc

O15519

O43676

Ensembl transtripts involved in fusion geneENST00000309955, ENST00000340870, 
ENST00000341222, ENST00000341582, 
ENST00000342795, ENST00000355558, 
ENST00000395148, ENST00000443227, 
ENST00000423241, ENST00000457277, 
ENST00000479953, ENST00000494258, 
ENST00000440180, ENST00000490965, 
ENST00000237889, ENST00000433898, 
ENST00000454214, 
Fusion gene scores* DoF score9 X 10 X 9=8104 X 3 X 6=72
# samples 128
** MAII scorelog2(12/810*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/72*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CFLAR [Title/Abstract] AND NDUFB3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCFLAR(202005162)-NDUFB3(201950182), # samples:3
Anticipated loss of major functional domain due to fusion event.CFLAR-NDUFB3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CFLAR-NDUFB3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCFLAR

GO:0060544

regulation of necroptotic process

21737330

HgeneCFLAR

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

HgeneCFLAR

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

9208847


check buttonFusion gene breakpoints across CFLAR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NDUFB3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-P3-A6T4-01ACFLARchr2

202005162

-NDUFB3chr2

201950182

+
ChimerDB4HNSCTCGA-P3-A6T4CFLARchr2

202005162

+NDUFB3chr2

201950182

+
ChimerDB4KIRCTCGA-A3-3346-01ACFLARchr2

202005162

+NDUFB3chr2

201950182

+
ChimerDB4UCSTCGA-N5-A59E-01ACFLARchr2

201981204

-NDUFB3chr2

201950182

+
ChimerDB4UCSTCGA-N5-A59ECFLARchr2

201981204

+NDUFB3chr2

201950182

+
ChimerDB4UCSTCGA-QN-A5NN-01ACFLARchr2

202014558

-NDUFB3chr2

201950182

+
ChimerDB4UCSTCGA-QN-A5NNCFLARchr2

202014558

+NDUFB3chr2

201950182

+


Top

Fusion Gene ORF analysis for CFLAR-NDUFB3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000309955ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000309955ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000309955ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000340870ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000340870ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000340870ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341222ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341222ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341222ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341582ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341582ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000341582ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000342795ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000342795ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000342795ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000355558ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000355558ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000355558ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000395148ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000395148ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000395148ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000443227ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000443227ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
5UTR-3CDSENST00000443227ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
Frame-shiftENST00000309955ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000309955ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000309955ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000340870ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000340870ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000340870ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000341582ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000341582ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000341582ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000342795ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000342795ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000342795ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000355558ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000355558ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000355558ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000423241ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000423241ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000423241ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000443227ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000443227ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000443227ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000457277ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000457277ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000457277ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000479953ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000479953ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000479953ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
Frame-shiftENST00000494258ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
Frame-shiftENST00000494258ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
Frame-shiftENST00000494258ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000309955ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000309955ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000309955ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000340870ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000340870ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000340870ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341222ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341222ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341222ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341582ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341582ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000341582ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000342795ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000342795ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000342795ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000355558ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000355558ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000355558ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000423241ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000423241ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000423241ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000440180ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000440180ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000440180ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000443227ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000443227ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000443227ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000457277ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000457277ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000457277ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000479953ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000479953ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
In-frameENST00000479953ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000341222ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000341222ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000341222ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000395148ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000423241ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000423241ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000423241ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000440180ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000457277ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000457277ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000457277ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000479953ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000479953ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000479953ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000237889CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000433898CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000454214CFLARchr2

202005162

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000490965ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000237889CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000237889CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000433898CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000433898CFLARchr2

202014558

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000454214CFLARchr2

201981204

+NDUFB3chr2

201950182

+
intron-3CDSENST00000494258ENST00000454214CFLARchr2

202014558

+NDUFB3chr2

201950182

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CFLAR-NDUFB3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CFLARchr2201981204+NDUFB3chr2201950181+2.65E-070.99999976
CFLARchr2202005162+NDUFB3chr2201950181+3.55E-111
CFLARchr2202014558+NDUFB3chr2201950181+3.79E-111
CFLARchr2201981204+NDUFB3chr2201950181+2.65E-070.99999976
CFLARchr2202005162+NDUFB3chr2201950181+3.55E-111
CFLARchr2202014558+NDUFB3chr2201950181+3.79E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CFLAR-NDUFB3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:202005162/chr2:201950182)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFLAR

O15519

NDUFB3

O43676

FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}.FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. {ECO:0000269|PubMed:27626371}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_73202481.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+51092_170202481.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_73202463.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+51092_170202463.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_73202222.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+5692_170202222.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_73202446.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+5892_170202446.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_73202293.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+5992_170202293.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_73202481.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+51092_170202481.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_73202222.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+4592_170202222.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_73106385.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_73202463.0DomainDED 1
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+4992_170202463.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_73106367.0DomainDED 1
TgeneNDUFB3chr2:202005162chr2:201950182ENST000002378891366_884699.0TransmembraneHelical
TgeneNDUFB3chr2:202005162chr2:201950182ENST000004338982466_884699.0TransmembraneHelical
TgeneNDUFB3chr2:202005162chr2:201950182ENST000004542142466_884699.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+4992_170106385.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+3892_170106367.0DomainDED 2
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_435202481.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510263_358202481.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_435202463.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510263_358202463.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_435202222.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56263_358202222.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_435202446.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58263_358202446.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_435202293.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59263_358202293.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_435202481.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510263_358202481.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_435202222.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45263_358202222.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_435106385.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49263_358106385.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_435202463.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49263_358202463.0RegionNote=Caspase
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_435106367.0RegionNote=Not proteolytically processed and involved in apoptosis inhibition
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38263_358106367.0RegionNote=Caspase


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Fusion Gene Sequence for CFLAR-NDUFB3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CFLAR-NDUFB3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_195202.0481.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_195202.0463.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_195202.0222.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_195202.0446.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_195202.0293.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_195202.0481.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_195202.0222.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_195202.0463.0CASP8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510192_435202.0481.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510192_435202.0463.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56192_435202.0222.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58192_435202.0446.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59192_435202.0293.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510192_435202.0481.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45192_435202.0222.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49192_435106.0385.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49192_435202.0463.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38192_435106.0367.0CASP3
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_305202.0481.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_305202.0463.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_305202.0222.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_305202.0446.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_305202.0293.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_305202.0481.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_305202.0222.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_305106.0385.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_305202.0463.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_305106.0367.0CASP8 propeptide
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510217_480202.0481.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510217_480202.0463.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56217_480202.0222.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58217_480202.0446.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59217_480202.0293.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510217_480202.0481.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45217_480202.0222.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49217_480106.0385.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49217_480202.0463.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38217_480106.0367.0CASP8 subunits p18 and p10
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510370_480202.0481.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510370_480202.0463.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56370_480202.0222.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58370_480202.0446.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59370_480202.0293.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510370_480202.0481.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45370_480202.0222.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_195106.0385.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49370_480106.0385.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49370_480202.0463.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_195106.0367.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38370_480106.0367.0CASP8
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+5101_227202.0481.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+5101_227202.0463.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+561_227202.0222.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+581_227202.0446.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+591_227202.0293.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+5101_227202.0481.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+451_227202.0222.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+491_227106.0385.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+491_227202.0463.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+381_227106.0367.0FADD
HgeneCFLARchr2:202005162chr2:201950182ENST00000309955+510192_480202.0481.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000340870+510192_480202.0463.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341222+56192_480202.0222.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000341582+58192_480202.0446.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000342795+59192_480202.0293.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000423241+510192_480202.0481.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000440180+45192_480202.0222.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000443227+49192_480106.0385.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000457277+49192_480202.0463.0TRAF1 and TRAF2
HgeneCFLARchr2:202005162chr2:201950182ENST00000479953+38192_480106.0367.0TRAF1 and TRAF2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CFLAR-NDUFB3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CFLAR-NDUFB3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource