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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CFLAR-NEDD8 (FusionGDB2 ID:16147)

Fusion Gene Summary for CFLAR-NEDD8

check button Fusion gene summary
Fusion gene informationFusion gene name: CFLAR-NEDD8
Fusion gene ID: 16147
HgeneTgene
Gene symbol

CFLAR

NEDD8

Gene ID

8837

4738

Gene nameCASP8 and FADD like apoptosis regulatorNEDD8 ubiquitin like modifier
SynonymsCASH|CASP8AP1|CLARP|Casper|FLAME|FLAME-1|FLAME1|FLIP|I-FLICE|MRIT|c-FLIP|c-FLIPL|c-FLIPR|c-FLIPS|cFLIPNEDD-8
Cytomap

2q33.1

14q12

Type of geneprotein-codingprotein-coding
DescriptionCASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like inNEDD8neddylinneural precursor cell expressed, developmentally down-regulated 8ubiquitin-like protein Nedd8
Modification date2020032220200327
UniProtAcc

O15519

UBE2F

Ensembl transtripts involved in fusion geneENST00000309955, ENST00000341582, 
ENST00000355558, ENST00000423241, 
ENST00000443227, ENST00000340870, 
ENST00000341222, ENST00000342795, 
ENST00000395148, ENST00000440180, 
ENST00000457277, ENST00000479953, 
ENST00000490965, ENST00000494258, 
ENST00000250495, ENST00000524927, 
ENST00000533242, 
Fusion gene scores* DoF score9 X 10 X 9=8103 X 2 X 3=18
# samples 123
** MAII scorelog2(12/810*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CFLAR [Title/Abstract] AND NEDD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCFLAR(202028807)-NEDD8(24686429), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCFLAR

GO:0060544

regulation of necroptotic process

21737330

HgeneCFLAR

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

HgeneCFLAR

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

9208847

TgeneNEDD8

GO:0045116

protein neddylation

10500095


check buttonFusion gene breakpoints across CFLAR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NEDD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QI-01ACFLARchr2

202028807

+NEDD8chr14

24686429

-


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Fusion Gene ORF analysis for CFLAR-NEDD8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000309955ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-3CDSENST00000341582ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-3CDSENST00000355558ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-3CDSENST00000423241ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-3CDSENST00000443227ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000309955ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000309955ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000341582ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000341582ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000355558ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000355558ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000423241ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000423241ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000443227ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
3UTR-intronENST00000443227ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000340870ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000341222ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000342795ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000395148ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000440180ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000457277ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000479953ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000490965ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-3CDSENST00000494258ENST00000250495CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000340870ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000340870ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000341222ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000341222ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000342795ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000342795ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000395148ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000395148ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000440180ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000440180ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000457277ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000457277ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000479953ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000479953ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000490965ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000490965ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000494258ENST00000524927CFLARchr2

202028807

+NEDD8chr14

24686429

-
intron-intronENST00000494258ENST00000533242CFLARchr2

202028807

+NEDD8chr14

24686429

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CFLAR-NEDD8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CFLAR-NEDD8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:202028807/:24686429)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CFLAR

O15519

NEDD8

UBE2F

FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:9880531}.185

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CFLAR-NEDD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CFLAR-NEDD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CFLAR-NEDD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CFLAR-NEDD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource