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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CFTR-SEC23IP (FusionGDB2 ID:16156)

Fusion Gene Summary for CFTR-SEC23IP

Fusion gene summary

Fusion gene information	Fusion gene name: CFTR-SEC23IP
	Fusion gene ID: 16156
		Hgene	Tgene
	Gene symbol	CFTR	SEC23IP
	Gene ID	1080	11196
	Gene name	CF transmembrane conductance regulator	SEC23 interacting protein
	Synonyms	ABC35\|ABCC7\|CF\|CFTR/MRP\|MRP7\|TNR-CFTR\|dJ760C5.1	MSTP053\|P125\|P125A
	Cytomap	7q31.2	10q26.11-q26.12
	Type of gene	protein-coding	protein-coding
	Description	cystic fibrosis transmembrane conductance regulatorcAMP-dependent chloride channelchannel conductance-controlling ATPasecystic fibrosis transmembrane conductance regulatingcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-f	SEC23-interacting protein
	Modification date	20200329	20200313
	UniProtAcc	P13569	.
	Ensembl transtripts involved in fusion gene	ENST00000003084, ENST00000454343, ENST00000608965,	ENST00000475542, ENST00000369075, ENST00000543134,
Fusion gene scores	* DoF score	6 X 5 X 3=90	7 X 9 X 4=252
	# samples	6	7
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CFTR [Title/Abstract] AND SEC23IP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CFTR(117199709)-SEC23IP(121685548), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CFTR	GO:0015701	bicarbonate transport	15010471\|19019741
Hgene	CFTR	GO:0034976	response to endoplasmic reticulum stress	21884936\|28067262
Hgene	CFTR	GO:1902476	chloride transmembrane transport	11524016\|11707463\|19019741
Hgene	CFTR	GO:1902943	positive regulation of voltage-gated chloride channel activity	22006324
Hgene	CFTR	GO:1904322	cellular response to forskolin	15010471\|19621064

Fusion gene breakpoints across CFTR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEC23IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-HU-A4HB-01A	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+

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Fusion Gene ORF analysis for CFTR-SEC23IP

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000003084	ENST00000475542	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
5CDS-intron	ENST00000454343	ENST00000475542	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
In-frame	ENST00000003084	ENST00000369075	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
In-frame	ENST00000003084	ENST00000543134	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
In-frame	ENST00000454343	ENST00000369075	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
In-frame	ENST00000454343	ENST00000543134	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
intron-3CDS	ENST00000608965	ENST00000369075	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
intron-3CDS	ENST00000608965	ENST00000543134	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+
intron-intron	ENST00000608965	ENST00000475542	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000003084

CFTR

chr7

117199709

ENST00000369075

SEC23IP

chr10

121685548

4179

1716

2597

836

ENST00000003084

CFTR

chr7

117199709

ENST00000543134

SEC23IP

chr10

121685548

2767

1716

2597

836

ENST00000454343

CFTR

chr7

117199709

ENST00000369075

SEC23IP

chr10

121685548

3996

1533

2414

775

ENST00000454343

CFTR

chr7

117199709

ENST00000543134

SEC23IP

chr10

121685548

2584

1533

2414

775

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000003084	ENST00000369075	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+	0.000426627	0.9995734
ENST00000003084	ENST00000543134	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+	0.000857176	0.99914277
ENST00000454343	ENST00000369075	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+	0.000571279	0.9994287
ENST00000454343	ENST00000543134	CFTR	chr7	117199709	+	SEC23IP	chr10	121685548	+	0.001195157	0.9988048

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Fusion Genomic Features for CFTR-SEC23IP

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CFTR	chr7	117199709	+	SEC23IP	chr10	121685547	+	3.31E-05	0.99996686
CFTR	chr7	117199709	+	SEC23IP	chr10	121685547	+	3.31E-05	0.99996686

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CFTR-SEC23IP

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:117199709/chr10:121685548)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CFTR P13569	.
FUNCTION: Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810). {ECO:0000269\|PubMed:10792060, ECO:0000269\|PubMed:11524016, ECO:0000269\|PubMed:11707463, ECO:0000269\|PubMed:12403779, ECO:0000269\|PubMed:12519745, ECO:0000269\|PubMed:12529365, ECO:0000269\|PubMed:12588899, ECO:0000269\|PubMed:14668433, ECO:0000269\|PubMed:15010471, ECO:0000269\|PubMed:16645176, ECO:0000269\|PubMed:17036051, ECO:0000269\|PubMed:1712898, ECO:0000269\|PubMed:17182731, ECO:0000269\|PubMed:19019741, ECO:0000269\|PubMed:19398555, ECO:0000269\|PubMed:19621064, ECO:0000269\|PubMed:22178883, ECO:0000269\|PubMed:25330774, ECO:0000269\|PubMed:26627831, ECO:0000269\|PubMed:26823428, ECO:0000269\|PubMed:26846474, ECO:0000269\|PubMed:27714810, ECO:0000269\|PubMed:27941075, ECO:0000269\|PubMed:28087700, ECO:0000269\|PubMed:8910473, ECO:0000269\|PubMed:9804160, ECO:0000305\|PubMed:19923167}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

81_365

528

1481.0

Domain

ABC transmembrane type-1 1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

81_365

467

1420.0

Domain

ABC transmembrane type-1 1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

458_465

528

1481.0

Nucleotide binding

ATP 1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

458_465

467

1420.0

Nucleotide binding

ATP 1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

147_195

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1_77

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

217_222

528

1481.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

244_298

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

320_339

528

1481.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

99_122

528

1481.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

147_195

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1_77

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

217_222

467

1420.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

244_298

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

320_339

467

1420.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

99_122

467

1420.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

123_146

528

1481.0

Transmembrane

Helical%3B Name%3D2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

196_216

528

1481.0

Transmembrane

Helical%3B Name%3D3

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

223_243

528

1481.0

Transmembrane

Helical%3B Name%3D4

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

299_319

528

1481.0

Transmembrane

Helical%3B Name%3D5

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

340_358

528

1481.0

Transmembrane

Helical%3B Name%3D6

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

78_98

528

1481.0

Transmembrane

Helical%3B Name%3D1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

123_146

467

1420.0

Transmembrane

Helical%3B Name%3D2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

196_216

467

1420.0

Transmembrane

Helical%3B Name%3D3

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

223_243

467

1420.0

Transmembrane

Helical%3B Name%3D4

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

299_319

467

1420.0

Transmembrane

Helical%3B Name%3D5

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

340_358

467

1420.0

Transmembrane

Helical%3B Name%3D6

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

78_98

467

1420.0

Transmembrane

Helical%3B Name%3D1

Tgene

SEC23IP

chr7:117199709

chr10:121685548

ENST00000369075

779_989

707

1443.0

Domain

DDHD

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1210_1443

528

1481.0

Domain

ABC transporter 2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

423_646

528

1481.0

Domain

ABC transporter 1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

859_1155

528

1481.0

Domain

ABC transmembrane type-1 2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1210_1443

467

1420.0

Domain

ABC transporter 2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

423_646

467

1420.0

Domain

ABC transporter 1

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

859_1155

467

1420.0

Domain

ABC transmembrane type-1 2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1244_1251

528

1481.0

Nucleotide binding

ATP 2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1244_1251

467

1420.0

Nucleotide binding

ATP 2

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

654_831

528

1481.0

Region

Intrinsically disordered R region

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

654_831

467

1420.0

Region

Intrinsically disordered R region

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1012_1013

528

1481.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1035_1095

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1117_1130

528

1481.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1152_1480

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

359_858

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

880_918

528

1481.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

940_990

528

1481.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1012_1013

467

1420.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1035_1095

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1117_1130

467

1420.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1152_1480

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

359_858

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

880_918

467

1420.0

Topological domain

Extracellular

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

940_990

467

1420.0

Topological domain

Cytoplasmic

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1014_1034

528

1481.0

Transmembrane

Helical%3B Name%3D10

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1096_1116

528

1481.0

Transmembrane

Helical%3B Name%3D11

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

1131_1151

528

1481.0

Transmembrane

Helical%3B Name%3D12

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

859_879

528

1481.0

Transmembrane

Helical%3B Name%3D7

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

919_939

528

1481.0

Transmembrane

Discontinuously helical%3B Name%3D8

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000003084

991_1011

528

1481.0

Transmembrane

Helical%3B Name%3D9

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1014_1034

467

1420.0

Transmembrane

Helical%3B Name%3D10

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1096_1116

467

1420.0

Transmembrane

Helical%3B Name%3D11

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

1131_1151

467

1420.0

Transmembrane

Helical%3B Name%3D12

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

859_879

467

1420.0

Transmembrane

Helical%3B Name%3D7

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

919_939

467

1420.0

Transmembrane

Discontinuously helical%3B Name%3D8

Hgene

CFTR

chr7:117199709

chr10:121685548

ENST00000454343

991_1011

467

1420.0

Transmembrane

Helical%3B Name%3D9

Tgene

SEC23IP

chr7:117199709

chr10:121685548

ENST00000369075

142_259

707

1443.0

Compositional bias

Note=Pro-rich

Tgene

SEC23IP

chr7:117199709

chr10:121685548

ENST00000369075

644_707

707

1443.0

Domain

Note=SAM

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Fusion Gene Sequence for CFTR-SEC23IP

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16156_16156_1_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000003084_SEC23IP_chr10_121685548_ENST00000369075_length(transcript)=4179nt_BP=1716nt
AATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCAGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTG
AGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTT
TTCAGCTGGACCAGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATCCCTTCTGTTGATTCTGCT
GACAATCTATCTGAAAAATTGGAAAGAGAATGGGATAGAGAGCTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGT
TTTTTCTGGAGATTTATGTTCTATGGAATCTTTTTATATTTAGGGGAAGTCACCAAAGCAGTACAGCCTCTCTTACTGGGAAGAATCATA
GCTTCCTATGACCCGGATAACAAGGAGGAACGCTCTATCGCGATTTATCTAGGCATAGGCTTATGCCTTCTCTTTATTGTGAGGACACTG
CTCCTACACCCAGCCATTTTTGGCCTTCATCACATTGGAATGCAGATGAGAATAGCTATGTTTAGTTTGATTTATAAGAAGACTTTAAAG
CTGTCAAGCCGTGTTCTAGATAAAATAAGTATTGGACAACTTGTTAGTCTCCTTTCCAACAACCTGAACAAATTTGATGAAGGACTTGCA
TTGGCACATTTCGTGTGGATCGCTCCTTTGCAAGTGGCACTCCTCATGGGGCTAATCTGGGAGTTGTTACAGGCGTCTGCCTTCTGTGGA
CTTGGTTTCCTGATAGTCCTTGCCCTTTTTCAGGCTGGGCTAGGGAGAATGATGATGAAGTACAGAGATCAGAGAGCTGGGAAGATCAGT
GAAAGACTTGTGATTACCTCAGAAATGATTGAAAATATCCAATCTGTTAAGGCATACTGCTGGGAAGAAGCAATGGAAAAAATGATTGAA
AACTTAAGACAAACAGAACTGAAACTGACTCGGAAGGCAGCCTATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTT
GTGGTGTTTTTATCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATCTCATTCTGCATTGTTCTG
CGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGATTTCTTACAA
AAGCAAGAATATAAGACATTGGAATATAACTTAACGACTACAGAAGTAGTGATGGAGAATGTAACAGCCTTCTGGGAGGAGGGATTTGGG
GAATTATTTGAGAAAGCAAAACAAAACAATAACAATAGAAAAACTTCTAATGGTGATGACAGCCTCTTCTTCAGTAATTTCTCACTTCTT
GGTACTCCTGTCCTGAAAGATATTAATTTCAAGATAGAAAGAGGACAGTTGTTGGCGGTTGCTGGATCCACTGGAGCAGGCAAGACTTCA
CTTCTAATGGTGATTATGGGAGAACTGGAGCCTTCAGAGGGTAAAATTAAGCACAGTGGAAGAATTTCATTCTGTTCTCAGTTTTCCTGG
ATTATGCCTGGCACCATTAAAGAAAATATCATCTTTGGTGTTTCCTATGATGAATATAGATACAGAAGCGTCATCAAAGCATGCCAACTA
GAAGAGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATG
GCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTT
GAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATG
TTTCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGAT
CCAGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTT
CATTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTA
AATGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAG
CAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGC
CGCCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAA
TCTGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGT
TTTACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGT
GATGGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACA
GTGAAAAAAATCAGTACCACATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTA
GTTGTATAGTTGTCAAAGTTATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTT
AGTGGGCTATTAAACTTGGATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATAT
GATTTTTAAGAGATTTATGTTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAA
TAATCAAGATCACTCATATCCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGA
TGCACCTTATTTTCAAGAAGTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTT
TGTCATCCAAGGTAGCTGTGCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGT
TTTCTATTAATTTCACTTATACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCT
TTGTAATATTTCACTTTGTTTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGT
GGGAATGCTGATTTTCTTTTGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATA
TATGATACACATTTTTTGTGTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTT
CTCTTGTCTTCCTTAAAAGTGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTT
AGCATTGGCTCCTAATGGTAGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTA
CAGCTGAGGCCAGGACAATAAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCT
TCATTTCTCTCTCTCAGGACTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTA

>16156_16156_1_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000003084_SEC23IP_chr10_121685548_ENST00000369075_length(amino acids)=836AA_BP=543
MSPDGPSRDPSARETMQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRR
CFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTL
KLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKI
SERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV
LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSL
LGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQ
LEEKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIA
MFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQT
LNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYW

--------------------------------------------------------------
>16156_16156_2_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000003084_SEC23IP_chr10_121685548_ENST00000543134_length(transcript)=2767nt_BP=1716nt
AATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCAGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTG
AGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTT
TTCAGCTGGACCAGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATCCCTTCTGTTGATTCTGCT
GACAATCTATCTGAAAAATTGGAAAGAGAATGGGATAGAGAGCTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGT
TTTTTCTGGAGATTTATGTTCTATGGAATCTTTTTATATTTAGGGGAAGTCACCAAAGCAGTACAGCCTCTCTTACTGGGAAGAATCATA
GCTTCCTATGACCCGGATAACAAGGAGGAACGCTCTATCGCGATTTATCTAGGCATAGGCTTATGCCTTCTCTTTATTGTGAGGACACTG
CTCCTACACCCAGCCATTTTTGGCCTTCATCACATTGGAATGCAGATGAGAATAGCTATGTTTAGTTTGATTTATAAGAAGACTTTAAAG
CTGTCAAGCCGTGTTCTAGATAAAATAAGTATTGGACAACTTGTTAGTCTCCTTTCCAACAACCTGAACAAATTTGATGAAGGACTTGCA
TTGGCACATTTCGTGTGGATCGCTCCTTTGCAAGTGGCACTCCTCATGGGGCTAATCTGGGAGTTGTTACAGGCGTCTGCCTTCTGTGGA
CTTGGTTTCCTGATAGTCCTTGCCCTTTTTCAGGCTGGGCTAGGGAGAATGATGATGAAGTACAGAGATCAGAGAGCTGGGAAGATCAGT
GAAAGACTTGTGATTACCTCAGAAATGATTGAAAATATCCAATCTGTTAAGGCATACTGCTGGGAAGAAGCAATGGAAAAAATGATTGAA
AACTTAAGACAAACAGAACTGAAACTGACTCGGAAGGCAGCCTATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTT
GTGGTGTTTTTATCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATCTCATTCTGCATTGTTCTG
CGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGATTTCTTACAA
AAGCAAGAATATAAGACATTGGAATATAACTTAACGACTACAGAAGTAGTGATGGAGAATGTAACAGCCTTCTGGGAGGAGGGATTTGGG
GAATTATTTGAGAAAGCAAAACAAAACAATAACAATAGAAAAACTTCTAATGGTGATGACAGCCTCTTCTTCAGTAATTTCTCACTTCTT
GGTACTCCTGTCCTGAAAGATATTAATTTCAAGATAGAAAGAGGACAGTTGTTGGCGGTTGCTGGATCCACTGGAGCAGGCAAGACTTCA
CTTCTAATGGTGATTATGGGAGAACTGGAGCCTTCAGAGGGTAAAATTAAGCACAGTGGAAGAATTTCATTCTGTTCTCAGTTTTCCTGG
ATTATGCCTGGCACCATTAAAGAAAATATCATCTTTGGTGTTTCCTATGATGAATATAGATACAGAAGCGTCATCAAAGCATGCCAACTA
GAAGAGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATG
GCTTCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTT
GAAGTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATG
TTTCTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGAT
CCAGTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTT
CATTTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTA
AATGAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAG
CAAGTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGC
CGCCGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAA
TCTGAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGT
TTTACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGT

>16156_16156_2_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000003084_SEC23IP_chr10_121685548_ENST00000543134_length(amino acids)=836AA_BP=543
MSPDGPSRDPSARETMQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRR
CFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTL
KLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKI
SERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV
LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSL
LGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQ
LEEKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESFEVGAGQVSVAYNSLDFEPEIFFALGSPIA
MFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRLHLELKESLSRMGSDLKQGFISSLKSAWQT
LNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGGRRIDYVLQEKPIESFNEYLFALQSHLCYW

--------------------------------------------------------------
>16156_16156_3_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000454343_SEC23IP_chr10_121685548_ENST00000369075_length(transcript)=3996nt_BP=1533nt
AATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCAGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTG
AGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTT
TTCAGCTGGACCAGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATCCCTTCTGTTGATTCTGCT
GACAATCTATCTGAAAAATTGGAAAGAGAATGGGATAGAGAGCTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGT
TTTTTCTGGAGATTTATGTTCTATGGAATCTTTTTATATTTAGGGGAAGTCACCAAAGCAGTACAGCCTCTCTTACTGGGAAGAATCATA
GCTTCCTATGACCCGGATAACAAGGAGGAACGCTCTATCGCGATTTATCTAGGCATAGGCTTATGCCTTCTCTTTATTGTGAGGACACTG
CTCCTACACCCAGCCATTTTTGGCCTTCATCACATTGGAATGCAGATGAGAATAGCTATGTTTAGTTTGATTTATAAGAAGACTTTAAAG
CTGTCAAGCCGTGTTCTAGATAAAATAAGTATTGGACAACTTGTTAGTCTCCTTTCCAACAACCTGAACAAATTTGATGAAGGACTTGCA
TTGGCACATTTCGTGTGGATCGCTCCTTTGCAAGTGGCACTCCTCATGGGGCTAATCTGGGAGTTGTTACAGGCGTCTGCCTTCTGTGGA
CTTGGTTTCCTGATAGTCCTTGCCCTTTTTCAGGCTGGGCTAGGGAGAATGATGATGAAGTACAGAGATCAGAGAGCTGGGAAGATCAGT
GAAAGACTTGTGATTACCTCAGAAATGATTGAAAATATCCAATCTGTTAAGGCATACTGCTGGGAAGAAGCAATGGAAAAAATGATTGAA
AACTTAAGACAAACAGAACTGAAACTGACTCGGAAGGCAGCCTATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTT
GTGGTGTTTTTATCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATCTCATTCTGCATTGTTCTG
CGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGATTTCTTACAA
AAGCAAGAATATAAGACATTGGAATATAACTTAACGACTACAGAAGTAGTGATGGAGAATGTAACAGCCTTCTGGGAGGAGACTTCACTT
CTAATGGTGATTATGGGAGAACTGGAGCCTTCAGAGGGTAAAATTAAGCACAGTGGAAGAATTTCATTCTGTTCTCAGTTTTCCTGGATT
ATGCCTGGCACCATTAAAGAAAATATCATCTTTGGTGTTTCCTATGATGAATATAGATACAGAAGCGTCATCAAAGCATGCCAACTAGAA
GAGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCT
TCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAA
GTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTT
CTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCA
GTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCAT
TTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAAT
GAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAA
GTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGC
CGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCT
GAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTT
ACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGAT
GGATGACAGAAGAGTGATTCATTAACAATTGCTCAGCCACAATTCTCGGATATAGGGATTCAAAAGACAGGACACAGAACTAACACAGTG
AAAAAAATCAGTACCACATTTGGACAGTATAGGTGAGAAAACATAATTATAAAAATGATGCCATGAAAAATTCCACAGATCAGTTTAGTT
GTATAGTTGTCAAAGTTATATGTGATATCAATGAAGAAATATTTGTAGCATGTAAACGGTTATTTCTGTTTCTTAAAAAGTATTGTTAGT
GGGCTATTAAACTTGGATTTTTCTTTTTATTAATGCAGTATGTTCTTTTTATTCAAGTATGAACTTGTTGAGAAACTATAGTAATATGAT
TTTTAAGAGATTTATGTTCTACTTAAAATGTGAATTGTACTTCTGAGCTGCCTTAATGCAAGGTCATTTATATTTGTTAAGAGGAAATAA
TCAAGATCACTCATATCCCAACTGAATCTGAGGTTTTATAAATCCCTCAAACGATTGCTGAGAGCCTGATTGTGGAAAGAAGTGAGATGC
ACCTTATTTTCAAGAAGTCCTGGGAAGCGCTCTCCTAGCACGTCCATTTCCAGGAGGAGAAGCAAGCAGATGAGAGGTTTTCCATTTTGT
CATCCAAGGTAGCTGTGCACTTGCCTTGTTGCTGAAGTTCCAATAATGTGAAAACCAAAGTAGAGGTTTTTTTCTTCTTCTTTTTGTTTT
CTATTAATTTCACTTATACCAAAGTGTTTGAAAGTATGAAATGTGTTGCTTCTGAGTTATATAAGGCTACTTCATGACAAGACTGCTTTG
TAATATTTCACTTTGTTTTACTACAAATTCAGATCACTTTGTTTTACTATAAATTCAGATTATCCAAATATTTTCCTAATACTATGTGGG
AATGCTGATTTTCTTTTGTTACGTAGTGGAAACATTTTGCATTGTTTACATAGTTCTCATGGAACATGGAAATTTTTGAAAGTGATATAT
GATACACATTTTTTGTGTATGTATTCTAATTAGTGTGAATAAAGCAGTAACATTAATGCATTTTTTAAGCAGCAAACTTATGTATTTCTC
TTGTCTTCCTTAAAAGTGTCCCCATGAACTCAGTGTTTATTCCCTTTTCATTTTGAGTACCTGCTTATATGGTCAGTATGTAACGTTAGC
ATTGGCTCCTAATGGTAGAATTAGAACAGCAAGATTGTAGAGCTGTAATTGACTCCAGACAACATAGATTTCAGCCACCTCATTCTACAG
CTGAGGCCAGGACAATAAATGCCTTTCCCAGACTGGGTAGTGGCAGATCTGGGATGGAATATGGTTTTCTTGATTCCCTTTCAGCCTTCA
TTTCTCTCTCTCAGGACTACTACTTTTTAATTACTTTTCACTTAATTTCCCAATACTGATGAAATAAAGAAAAATGAGGGTTATTTATAT

>16156_16156_3_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000454343_SEC23IP_chr10_121685548_ENST00000369075_length(amino acids)=775AA_BP=482
MSPDGPSRDPSARETMQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRR
CFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTL
KLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKI
SERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV
LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEETSLLMVIMGELEPSEGKIKHSGRISFCSQFSW
IMPGTIKENIIFGVSYDEYRYRSVIKACQLEEKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESF
EVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRL
HLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGG

--------------------------------------------------------------
>16156_16156_4_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000454343_SEC23IP_chr10_121685548_ENST00000543134_length(transcript)=2584nt_BP=1533nt
AATTGGAAGCAAATGACATCACAGCAGGTCAGAGAAAAAGGGTTGAGCGGCAGGCACCCAGAGTAGTAGGTCTTTGGCATTAGGAGCTTG
AGCCCAGACGGCCCTAGCAGGGACCCCAGCGCCCGAGAGACCATGCAGAGGTCGCCTCTGGAAAAGGCCAGCGTTGTCTCCAAACTTTTT
TTCAGCTGGACCAGACCAATTTTGAGGAAAGGATACAGACAGCGCCTGGAATTGTCAGACATATACCAAATCCCTTCTGTTGATTCTGCT
GACAATCTATCTGAAAAATTGGAAAGAGAATGGGATAGAGAGCTGGCTTCAAAGAAAAATCCTAAACTCATTAATGCCCTTCGGCGATGT
TTTTTCTGGAGATTTATGTTCTATGGAATCTTTTTATATTTAGGGGAAGTCACCAAAGCAGTACAGCCTCTCTTACTGGGAAGAATCATA
GCTTCCTATGACCCGGATAACAAGGAGGAACGCTCTATCGCGATTTATCTAGGCATAGGCTTATGCCTTCTCTTTATTGTGAGGACACTG
CTCCTACACCCAGCCATTTTTGGCCTTCATCACATTGGAATGCAGATGAGAATAGCTATGTTTAGTTTGATTTATAAGAAGACTTTAAAG
CTGTCAAGCCGTGTTCTAGATAAAATAAGTATTGGACAACTTGTTAGTCTCCTTTCCAACAACCTGAACAAATTTGATGAAGGACTTGCA
TTGGCACATTTCGTGTGGATCGCTCCTTTGCAAGTGGCACTCCTCATGGGGCTAATCTGGGAGTTGTTACAGGCGTCTGCCTTCTGTGGA
CTTGGTTTCCTGATAGTCCTTGCCCTTTTTCAGGCTGGGCTAGGGAGAATGATGATGAAGTACAGAGATCAGAGAGCTGGGAAGATCAGT
GAAAGACTTGTGATTACCTCAGAAATGATTGAAAATATCCAATCTGTTAAGGCATACTGCTGGGAAGAAGCAATGGAAAAAATGATTGAA
AACTTAAGACAAACAGAACTGAAACTGACTCGGAAGGCAGCCTATGTGAGATACTTCAATAGCTCAGCCTTCTTCTTCTCAGGGTTCTTT
GTGGTGTTTTTATCTGTGCTTCCCTATGCACTAATCAAAGGAATCATCCTCCGGAAAATATTCACCACCATCTCATTCTGCATTGTTCTG
CGCATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACAAAATACAGGATTTCTTACAA
AAGCAAGAATATAAGACATTGGAATATAACTTAACGACTACAGAAGTAGTGATGGAGAATGTAACAGCCTTCTGGGAGGAGACTTCACTT
CTAATGGTGATTATGGGAGAACTGGAGCCTTCAGAGGGTAAAATTAAGCACAGTGGAAGAATTTCATTCTGTTCTCAGTTTTCCTGGATT
ATGCCTGGCACCATTAAAGAAAATATCATCTTTGGTGTTTCCTATGATGAATATAGATACAGAAGCGTCATCAAAGCATGCCAACTAGAA
GAGAAAAAAGCAGCGTCAGAAAAGAAGGCAGTGGCGGCCACTTCTACAAAAGGACAAGAGCAAAGTGCCCAGAAGACTAAAGACATGGCT
TCCCTCCCCTCAGAATCCAATGAGCCAAAGAGGAAACTTCCAGTTGGTGCTTGCGTGTCTTCTGTGTGTGTGAATTATGAATCTTTTGAA
GTTGGCGCCGGACAGGTTTCTGTTGCTTACAACTCATTAGATTTTGAACCAGAGATATTCTTTGCCTTGGGGTCTCCAATTGCTATGTTT
CTCACTATTCGAGGAGTTGATAGGATAGATGAGAATTACAGCCTTCCTACCTGTAAAGGGTTCTTCAATATTTATCATCCGCTTGATCCA
GTGGCATATAGATTAGAACCTATGATTGTTCCAGATTTGGACCTAAAAGCTGTTCTCATTCCACATCACAAAGGCAGAAAAAGACTTCAT
TTAGAATTGAAAGAGAGTCTCTCTCGTATGGGATCTGATTTGAAGCAGGGTTTTATTAGCTCTCTCAAAAGTGCTTGGCAGACATTAAAT
GAGTTTGCCCGTGCTCATACGTCTTCAACCCAGTTGCAAGAAGAATTGGAGAAGGTGGCCAATCAGATCAAAGAAGAAGAAGAAAAGCAA
GTAGTTGAAGCAGAAAAGGTTGTTGAAAGTCCAGATTTTTCCAAGGATGAGGACTACTTAGGAAAGGTTGGAATGTTAAATGGAGGCCGC
CGAATTGACTACGTTCTCCAAGAAAAACCAATAGAGAGTTTTAATGAATACCTTTTCGCTCTTCAGAGTCACTTATGCTATTGGGAATCT
GAAGATACTGCTCTGTTACTACTTAAAGAAATTTATCGAACAATGAACATTAGTCCAGAACAGCCCCAGCATTGATCAAACTTCAGTTTT
ACTGTACTTTCTTGTCTGCACAGAAAGTCCCAGTACAACTTCCATTGCTGAGAAAATCCTCAGAGGACTTTCCCACTTCGCTCCTGTGAT

>16156_16156_4_CFTR-SEC23IP_CFTR_chr7_117199709_ENST00000454343_SEC23IP_chr10_121685548_ENST00000543134_length(amino acids)=775AA_BP=482
MSPDGPSRDPSARETMQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPKLINALRR
CFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTL
KLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKI
SERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV
LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEETSLLMVIMGELEPSEGKIKHSGRISFCSQFSW
IMPGTIKENIIFGVSYDEYRYRSVIKACQLEEKKAASEKKAVAATSTKGQEQSAQKTKDMASLPSESNEPKRKLPVGACVSSVCVNYESF
EVGAGQVSVAYNSLDFEPEIFFALGSPIAMFLTIRGVDRIDENYSLPTCKGFFNIYHPLDPVAYRLEPMIVPDLDLKAVLIPHHKGRKRL
HLELKESLSRMGSDLKQGFISSLKSAWQTLNEFARAHTSSTQLQEELEKVANQIKEEEEKQVVEAEKVVESPDFSKDEDYLGKVGMLNGG

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Fusion Gene PPI Analysis for CFTR-SEC23IP

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CFTR	chr7:117199709	chr10:121685548	ENST00000003084	+	11	27	1386_1480	528.0	1481.0	GORASP2
Hgene	CFTR	chr7:117199709	chr10:121685548	ENST00000454343	+	10	26	1386_1480	467.0	1420.0	GORASP2
Tgene	SEC23IP	chr7:117199709	chr10:121685548	ENST00000369075		11	19	1_367	707.0	1443.0	SEC23A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CFTR-SEC23IP

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CFTR-SEC23IP

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source