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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHCHD1-SUFU (FusionGDB2 ID:16216)

Fusion Gene Summary for CHCHD1-SUFU

Fusion gene summary

Fusion gene information	Fusion gene name: CHCHD1-SUFU
	Fusion gene ID: 16216
		Hgene	Tgene
	Gene symbol	CHCHD1	SUFU
	Gene ID	118487	51684
	Gene name	coiled-coil-helix-coiled-coil-helix domain containing 1	SUFU negative regulator of hedgehog signaling
	Synonyms	C10orf34\|C2360\|MRP-S37	JBTS32\|PRO1280\|SUFUH\|SUFUXL
	Cytomap	10q22.2	10q24.32
	Type of gene	protein-coding	protein-coding
	Description	coiled-coil-helix-coiled-coil-helix domain-containing protein 128S ribosomal protein S37, mitochondrialmitochondrial small ribosomal subunit protein mS37nuclear protein C2360	suppressor of fused homolog
	Modification date	20200313	20200313
	UniProtAcc	Q96BP2	.
	Ensembl transtripts involved in fusion gene	ENST00000372833, ENST00000372837,	ENST00000369899, ENST00000423559, ENST00000471000, ENST00000369902,
Fusion gene scores	* DoF score	2 X 1 X 2=4	8 X 8 X 8=512
	# samples	2	12
	** MAII score	log2(2/4*10)=2.32192809488736	log2(12/512*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHCHD1 [Title/Abstract] AND SUFU [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHCHD1(75542199)-SUFU(104386932), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SUFU	GO:0000122	negative regulation of transcription by RNA polymerase II	10564661

Fusion gene breakpoints across CHCHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SUFU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-A7NN-01A	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+

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Fusion Gene ORF analysis for CHCHD1-SUFU

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000372833	ENST00000369899	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
5CDS-intron	ENST00000372833	ENST00000423559	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
5CDS-intron	ENST00000372833	ENST00000471000	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
5CDS-intron	ENST00000372837	ENST00000369899	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
5CDS-intron	ENST00000372837	ENST00000423559	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
5CDS-intron	ENST00000372837	ENST00000471000	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
In-frame	ENST00000372833	ENST00000369902	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+
In-frame	ENST00000372837	ENST00000369902	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000372837

CHCHD1

chr10

75542199

ENST00000369902

SUFU

chr10

104386932

4622

1083

2347

2892

181

ENST00000372833

CHCHD1

chr10

75542199

ENST00000369902

SUFU

chr10

104386932

3795

256

1520

2065

181

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372837	ENST00000369902	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+	0.094523996	0.90547603
ENST00000372833	ENST00000369902	CHCHD1	chr10	75542199	+	SUFU	chr10	104386932	+	0.028787583	0.9712124

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Fusion Genomic Features for CHCHD1-SUFU

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CHCHD1	chr10	75542199	+	SUFU	chr10	104386931	+	2.41E-06	0.9999976
CHCHD1	chr10	75542199	+	SUFU	chr10	104386931	+	2.41E-06	0.9999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHCHD1-SUFU

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:75542199/chr10:104386932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHCHD1 Q96BP2	.
	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHCHD1

chr10:75542199

chr10:104386932

ENST00000372833

42_84

119.0

Domain

CHCH

Hgene

CHCHD1

chr10:75542199

chr10:104386932

ENST00000372833

45_55

119.0

Motif

Cx9C motif 1

Hgene

CHCHD1

chr10:75542199

chr10:104386932

ENST00000372833

66_76

119.0

Motif

Cx9C motif 2

Tgene

SUFU

chr10:75542199

chr10:104386932

ENST00000369899

279_360

434.0

Region

Intrinsically disordered

Tgene

SUFU

chr10:75542199

chr10:104386932

ENST00000423559

279_360

482.0

Region

Intrinsically disordered

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SUFU

chr10:75542199

chr10:104386932

ENST00000369902

279_360

432

485.0

Region

Intrinsically disordered

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Fusion Gene Sequence for CHCHD1-SUFU

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16216_16216_1_CHCHD1-SUFU_CHCHD1_chr10_75542199_ENST00000372833_SUFU_chr10_104386932_ENST00000369902_length(transcript)=3795nt_BP=256nt
AGCTTGGTGCGCTATGGCGACACCCAGCCTGCGGGGTCGTCTGGCGCGGTTTGGGAACCCGCGGAAGCCTGTGCTGAAGCCCAATAAACC
TCTCATTCTAGCTAACCGCGTCGGGGAGCGGCGCCGGGAGAAGGGCGAGGCGACTTGCATCACGGAGATGTCGGTGATGATGGCTTGCTG
GAAGCAGAATGAATTCCGCGACGATGCGTGCAGAAAAGAGATCCAGGGCTTCCTCGATTGTGCCGCGAGGGCTCAGATTCTGTTGACCGA
AGAGTTTGTAGAGAAAATGTTGGAGGATTTAGAAGATTTGACTTCTCCAGAGGAATTCAAACTTCCCAAAGAGTACAGCTGGCCTGAAAA
GAAGCTGAAGGTCTCCATCCTGCCTGACGTGGTGTTCGACAGTCCGCTACACTAGCCTGGGCTGGGCCCTGCAGTGGCCAGCAGGGAGCC
CAGCTGCTCCCCAGTGACTTCCAGTGTAACAGTTGTGTCAACGAGATCTCCACAAATAAAAGGACAAGTGTGAGGAAGACTGCGCAGTGC
CACCCCGCAGCCCAGTGGGGTGCCATGCACAGGCCACAGGCCCTCCACCTCACCTCCAGCTCAGGGGCCGCACCCCGCCGCTGGCTAAGC
CTTGTGACCCATCAGGCCAGTGAGTGGGCAAATGCGGACCCTCCCTGCCTGCAGCCTGCACAGATTCTGGTTTGAGGTTTGACTCTGGAC
CCTGGCTGTGCCCCTAGGTGGAGACAGCCCTCTTTCTCACCTACCCCCTGCCGCACAGCCCAGCAGGAGGGAGGCGGACAGCCAGATGCA
GAGCGAGTGGATGCACTTCCCAGCTCATCTCTGGAAGCCTTTGCTACTCAAGCTCCTCTGGCCGCGGAACAATTCCTCTGATCATGTTTG
GTTTTCTTCTTCCTTATTTTATTTTGTAGAAACCGGGTGGTATTTTATTGCTCTGCAAAGATGTCCAGAAGCCATGTATATAATGTTTTT
TAAACAGAACTTCATTCCCCGTTGAACTTTCGCATTCTCTGACAGAGGCCTAGGGCTGTATCTCTCCCTGGGCTGCCACCAGAGAAGGTG
CTTGGTGTTCGCCTGCCAGCCCAGAGCCCTGGAGGAGCCGGCTGCACAGAGAGGCTTTTCTTCCCAGCTGGGCCTGGTGGAGCCCGGGGC
AGGGGGAGAGTAGAGACACTCCCTTGTGCAGCTTTGAGCCTAGTTTAGCTGGGGCCAGGGAGGGGTGCTACTGTTTTCCAAGTGAATGGG
TCTCAAAGACTTGGTGACCCCAGCCTCATCTTCTAGGCCTTTTCCACCCAACCAGGCCTACCTGGGAGAGGGTGAGGTTCAGCACATCAC
ACACCATCCCCACTGTCATTCAGGGCCTGGGTCTCCAGCTCTGTAACCAGTCCTGTCCCATTTCCTCAGTCCCTGGGCCTCCCAGCCTTC
AGGCTGTAGGGCTGCCTTACTAAAATTGAAAAATCCACCTCTTAACATCTCTTTCACTTTGGTTTTGCTAACACTGCTCTCTGCTGCCCT
CCCATCCTCCCTGTATCCATTCATGCCCTATCTTTCATTCTCCACTCCTAATCCCTCTCCTTTCTGGCATCCTGGCCTCTCGTGGTCCTC
AGCCCCTCACCCCCAGTACTGCAGATCTCACAGTTTGCCTTCCAGAAGCCAGCCTATCTCTAGCCCATGGTTTTGGAGTTCCTCTCGGGT
TATCTCCCACGCCTGACCTGGAACCAGCAAGCCCCTTTCCTGCCTTCTTACCCCCAACTCTAGGGATGGGACTGTTACAATACTTCAAGA
TCACTCTTTACACCTCTTCAAAGCAAAGTCATGACAATGCAGGGCTCCTCATTGCTCCCATCTGCCTCTGCTGCACACACAGGCACCAGC
AGGGATGCCACAGGAGTGCCCACAGGGTGCAGGACTCCACTGATGAGAGATCCAGCCAAAGAGCTGCCCCCAGGGGTATGAGGGCACCAG
CTGGGTTCTCCAGGGAGCAGGAGTTGGACCTCCATGGAGCCACTAGGCCTGGCCTCCTCTACACATCCCCAGGGCTATCTGGTTAATTCC
ATCAAGCTCAGAGTTAAAAGGCATATCAGCCTGGAGTATTTGGGAGAGACTGGCTGCAGATCCCCGCCAGCCAAGATGCAAGCCACTCGG
GACCTGATGTCGGCAGCTGTGCCTCTACTGCCCTGAGGACTTACCAGAGGGAGCCCTACTGGCCTTCCCCCACCACAGCAGCCCTGCCTG
TGAAGCTCTTGTTTCTGACATTTCACAGGCAGAGAGGTGCCATCAGTTCGCCTCCATTCCTTGCCACCATGACCAGCCTCTCCCTGAACT
CTCTCTTGCTCGGGACCTGCCTGAGGGCTCCCTGCTGCAGTTCGCCGTACTTCCATCTGCTGGGTGCCTCCATCGTTGGTTGGGTGGGGA
TGGGGCATTTTCTGAGCTAAGCTTTGTCATTAGTTTGTGAAGCACCTGGTCAGCAACCTGCCCCAGACCTGGAGGGTCTTTGTGGACTGA
AGGTAGACACCAGCCAGCATGGTGGCCCTGTTCTGGGGGAGCAGGGTAAGGCAGGAGGAAGTGGGTGAGCTCCGAGATGATGAGCACATG
AAGCCTGTGGCCCCTTCGTACCTGCAATATGTCAGGAGCCTCACGCTCACCCAAGATCCTGCAGGGGCCAGGCTCCATCTCACTGGCTCT
GAGGGCAGGACAGGGTATCACACATTTCTCACCAGGCCTCCTTTCCTATGGGCATTGGTGCCTCCCAGAGGTTTCTTGGGCTGCTGGCTG
GTGAGAGAGGACCCTTAAAGAAGATCAAGCCAAGCTGACCTTGGACCCTGTCCAGCACAGCTTCTGGCACAGGATGCTTGGTGAATGTAC
CCTTTCTTTCCCTCCCTGCAGCTCTGAGGGAGCCCCTGACCTTGTAGTGGGTGGAGGAGGTAAGGGGCCTCCCTCCCTAAATCTGCCTCT
TCTGCAAGCTACTTGGAGACTTGCCTAGTTGTACCCACCCCTCCAGGTCCCTGGTGCTAGAGCTTCTGAGAAGGGCCTTTCCCTTTCCTC
TTTGCCTGCTATATAAGGCAGGCTCCTGTGGCTCTGCTGGCTCAGTGTGGGCTGCAGGAGGACTGCAGACTCAGCTGCAATTCTGAGGGG
GGTTTGGGAGGCTTGTGCGAGGTCTCAGGCCTGTGTGGGGAGCTGGTGCCTCTTCCTGCCCGTATCTTTCTCTTCCAAGGGCAGTGCTCC
AAGGCAGGGACTGGAGAAGCCAAGGGGAGAGTCTAAAAGGGCTAGAGCATTTTTAAAAATAGACACAGGGTCTTGGGACTGGGGTTTCGG
ATTGAGTTGCAAGCAGGGAGAAAACCTGAAGGTCGGTGCCCCTATGGGGCTGACCAGTAGAGAATTTCCTTTACTGTATTTTTGTGTCTG
GTCTTCCCTTTCTGGCTTCTAGGACATCCATGCCAGGTGAGGTGCCTGGGTCCCTGTTACAAGTCAGGAGCCCTGTAGGGAGACCCCTCC
TTTTGTACAAGTACCTGAATGCTGCGACAAGCAGATTTTTGTAAAATTTTATATTAGTTTTTAATGTCAGTGGCGACTCGGTTCCTGGGG
CTGCAGCCAGCCTGGGACTTTTGTAAGAATTTTTGGGTGACTCACTTAGATGTCGTTTCCTTCTTGCCCCCTCTTCCTCTCTGTAATCTA
AGTGCATTAAACATCTTTGCAGAAGTGCCTGGGTTGTGTGCTCATTTCTGGCTGCCTGAAGTAGTGGAGCCGGAAGCCCGGGGCCCTGGC

>16216_16216_1_CHCHD1-SUFU_CHCHD1_chr10_75542199_ENST00000372833_SUFU_chr10_104386932_ENST00000369902_length(amino acids)=181AA_BP=
MLPSHPPCIHSCPIFHSPLLIPLLSGILASRGPQPLTPSTADLTVCLPEASLSLAHGFGVPLGLSPTPDLEPASPFPAFLPPTLGMGLLQ
YFKITLYTSSKQSHDNAGLLIAPICLCCTHRHQQGCHRSAHRVQDSTDERSSQRAAPRGMRAPAGFSREQELDLHGATRPGLLYTSPGLS

--------------------------------------------------------------
>16216_16216_2_CHCHD1-SUFU_CHCHD1_chr10_75542199_ENST00000372837_SUFU_chr10_104386932_ENST00000369902_length(transcript)=4622nt_BP=1083nt
CGCAAAGCCTGCCGGGAGCTTGGTGCGCTATGGCGACACCCAGCCTGCGGGGTCGTCTGGCGCGGTTTGGGAACCCGCGGAAGCCTGTGC
TGAAGCCCAATAAACCTCTCATTCTAGCTAACCGCGTCGGGGAGCGGCGCCGGGAGAAGGGCGGTGACCGATGGCTCCTGGGGTGCTTTC
TCAGGAAAAGAATGGGGGAGATAGAAGTAATGATTCTCCCTGCCTTTTGCTAGGAAAGGCCCTTTCATTCATTTGGGAGGTATATTATTC
ACGCCAAAGTGGGAAAGGTTACAGTTTTGAAGGCTGTGTGATCTTGACGGATTTATTCATTGCTCTGAACTTTCGAGTTACTGTACGTAA
AATGAGGCTAACCAATACCACCTTAAAGAATGTTGTGAGTGTCAGATGAAGTAATGAATGGGAAAATCATTTTGAAAAATGTAAATTGCT
GCTCAAGTAGACATTATTGTGTGAAATAGAACTAAAGAGACTAAAACTAAATAATGACAATAGTTTGGTTTCCTGTCTAGGCTTAATTGT
TAGCTGAGATAGTAGCTTCTGAACATAGTCTCATTTGTAGGTCCCAACGCCCTTTTGTTGAAAAGAGGCTGACATAGATCTCTCCAGGCT
GGTTAACATCTTCATGTGCTTTAGGGCATTGTGAGAACTATGGGCCTACATCAGGACAAACTTGATTGATTGATTGGTTTTTTGGGTCAG
ATCTTAAAAGTCTGGACTAGACAAACTGTAGAGCTGTCATTCTTGTATTTGTTTTGTGTTTTCAGGAAGCCCGAAAGATGAGATCAATAC
AGGAAACCCTGGGAGAGTCTGGGAGTTTACTTCCAAATAAATTGAATAAGTTGTTACAGAGGTTTCCTAACAAACCTTACCTCAGCTGAA
AATGGACAAGTATTTTCAATGACTGAAATATAGCTTCTGACAACTATGCAGAGGCATTTTAGAGACATTGGCATTGCCATGCCCTCTTTG
GAGGGTAGAAGAGGCAAAACACTTTTTTCACCCTTTGGAATCATAGTATGGGTAGAAGTTATGATTTATCTTGAAATAAAATCCTCTGAA
CAGATTCTGTTGACCGAAGAGTTTGTAGAGAAAATGTTGGAGGATTTAGAAGATTTGACTTCTCCAGAGGAATTCAAACTTCCCAAAGAG
TACAGCTGGCCTGAAAAGAAGCTGAAGGTCTCCATCCTGCCTGACGTGGTGTTCGACAGTCCGCTACACTAGCCTGGGCTGGGCCCTGCA
GTGGCCAGCAGGGAGCCCAGCTGCTCCCCAGTGACTTCCAGTGTAACAGTTGTGTCAACGAGATCTCCACAAATAAAAGGACAAGTGTGA
GGAAGACTGCGCAGTGCCACCCCGCAGCCCAGTGGGGTGCCATGCACAGGCCACAGGCCCTCCACCTCACCTCCAGCTCAGGGGCCGCAC
CCCGCCGCTGGCTAAGCCTTGTGACCCATCAGGCCAGTGAGTGGGCAAATGCGGACCCTCCCTGCCTGCAGCCTGCACAGATTCTGGTTT
GAGGTTTGACTCTGGACCCTGGCTGTGCCCCTAGGTGGAGACAGCCCTCTTTCTCACCTACCCCCTGCCGCACAGCCCAGCAGGAGGGAG
GCGGACAGCCAGATGCAGAGCGAGTGGATGCACTTCCCAGCTCATCTCTGGAAGCCTTTGCTACTCAAGCTCCTCTGGCCGCGGAACAAT
TCCTCTGATCATGTTTGGTTTTCTTCTTCCTTATTTTATTTTGTAGAAACCGGGTGGTATTTTATTGCTCTGCAAAGATGTCCAGAAGCC
ATGTATATAATGTTTTTTAAACAGAACTTCATTCCCCGTTGAACTTTCGCATTCTCTGACAGAGGCCTAGGGCTGTATCTCTCCCTGGGC
TGCCACCAGAGAAGGTGCTTGGTGTTCGCCTGCCAGCCCAGAGCCCTGGAGGAGCCGGCTGCACAGAGAGGCTTTTCTTCCCAGCTGGGC
CTGGTGGAGCCCGGGGCAGGGGGAGAGTAGAGACACTCCCTTGTGCAGCTTTGAGCCTAGTTTAGCTGGGGCCAGGGAGGGGTGCTACTG
TTTTCCAAGTGAATGGGTCTCAAAGACTTGGTGACCCCAGCCTCATCTTCTAGGCCTTTTCCACCCAACCAGGCCTACCTGGGAGAGGGT
GAGGTTCAGCACATCACACACCATCCCCACTGTCATTCAGGGCCTGGGTCTCCAGCTCTGTAACCAGTCCTGTCCCATTTCCTCAGTCCC
TGGGCCTCCCAGCCTTCAGGCTGTAGGGCTGCCTTACTAAAATTGAAAAATCCACCTCTTAACATCTCTTTCACTTTGGTTTTGCTAACA
CTGCTCTCTGCTGCCCTCCCATCCTCCCTGTATCCATTCATGCCCTATCTTTCATTCTCCACTCCTAATCCCTCTCCTTTCTGGCATCCT
GGCCTCTCGTGGTCCTCAGCCCCTCACCCCCAGTACTGCAGATCTCACAGTTTGCCTTCCAGAAGCCAGCCTATCTCTAGCCCATGGTTT
TGGAGTTCCTCTCGGGTTATCTCCCACGCCTGACCTGGAACCAGCAAGCCCCTTTCCTGCCTTCTTACCCCCAACTCTAGGGATGGGACT
GTTACAATACTTCAAGATCACTCTTTACACCTCTTCAAAGCAAAGTCATGACAATGCAGGGCTCCTCATTGCTCCCATCTGCCTCTGCTG
CACACACAGGCACCAGCAGGGATGCCACAGGAGTGCCCACAGGGTGCAGGACTCCACTGATGAGAGATCCAGCCAAAGAGCTGCCCCCAG
GGGTATGAGGGCACCAGCTGGGTTCTCCAGGGAGCAGGAGTTGGACCTCCATGGAGCCACTAGGCCTGGCCTCCTCTACACATCCCCAGG
GCTATCTGGTTAATTCCATCAAGCTCAGAGTTAAAAGGCATATCAGCCTGGAGTATTTGGGAGAGACTGGCTGCAGATCCCCGCCAGCCA
AGATGCAAGCCACTCGGGACCTGATGTCGGCAGCTGTGCCTCTACTGCCCTGAGGACTTACCAGAGGGAGCCCTACTGGCCTTCCCCCAC
CACAGCAGCCCTGCCTGTGAAGCTCTTGTTTCTGACATTTCACAGGCAGAGAGGTGCCATCAGTTCGCCTCCATTCCTTGCCACCATGAC
CAGCCTCTCCCTGAACTCTCTCTTGCTCGGGACCTGCCTGAGGGCTCCCTGCTGCAGTTCGCCGTACTTCCATCTGCTGGGTGCCTCCAT
CGTTGGTTGGGTGGGGATGGGGCATTTTCTGAGCTAAGCTTTGTCATTAGTTTGTGAAGCACCTGGTCAGCAACCTGCCCCAGACCTGGA
GGGTCTTTGTGGACTGAAGGTAGACACCAGCCAGCATGGTGGCCCTGTTCTGGGGGAGCAGGGTAAGGCAGGAGGAAGTGGGTGAGCTCC
GAGATGATGAGCACATGAAGCCTGTGGCCCCTTCGTACCTGCAATATGTCAGGAGCCTCACGCTCACCCAAGATCCTGCAGGGGCCAGGC
TCCATCTCACTGGCTCTGAGGGCAGGACAGGGTATCACACATTTCTCACCAGGCCTCCTTTCCTATGGGCATTGGTGCCTCCCAGAGGTT
TCTTGGGCTGCTGGCTGGTGAGAGAGGACCCTTAAAGAAGATCAAGCCAAGCTGACCTTGGACCCTGTCCAGCACAGCTTCTGGCACAGG
ATGCTTGGTGAATGTACCCTTTCTTTCCCTCCCTGCAGCTCTGAGGGAGCCCCTGACCTTGTAGTGGGTGGAGGAGGTAAGGGGCCTCCC
TCCCTAAATCTGCCTCTTCTGCAAGCTACTTGGAGACTTGCCTAGTTGTACCCACCCCTCCAGGTCCCTGGTGCTAGAGCTTCTGAGAAG
GGCCTTTCCCTTTCCTCTTTGCCTGCTATATAAGGCAGGCTCCTGTGGCTCTGCTGGCTCAGTGTGGGCTGCAGGAGGACTGCAGACTCA
GCTGCAATTCTGAGGGGGGTTTGGGAGGCTTGTGCGAGGTCTCAGGCCTGTGTGGGGAGCTGGTGCCTCTTCCTGCCCGTATCTTTCTCT
TCCAAGGGCAGTGCTCCAAGGCAGGGACTGGAGAAGCCAAGGGGAGAGTCTAAAAGGGCTAGAGCATTTTTAAAAATAGACACAGGGTCT
TGGGACTGGGGTTTCGGATTGAGTTGCAAGCAGGGAGAAAACCTGAAGGTCGGTGCCCCTATGGGGCTGACCAGTAGAGAATTTCCTTTA
CTGTATTTTTGTGTCTGGTCTTCCCTTTCTGGCTTCTAGGACATCCATGCCAGGTGAGGTGCCTGGGTCCCTGTTACAAGTCAGGAGCCC
TGTAGGGAGACCCCTCCTTTTGTACAAGTACCTGAATGCTGCGACAAGCAGATTTTTGTAAAATTTTATATTAGTTTTTAATGTCAGTGG
CGACTCGGTTCCTGGGGCTGCAGCCAGCCTGGGACTTTTGTAAGAATTTTTGGGTGACTCACTTAGATGTCGTTTCCTTCTTGCCCCCTC
TTCCTCTCTGTAATCTAAGTGCATTAAACATCTTTGCAGAAGTGCCTGGGTTGTGTGCTCATTTCTGGCTGCCTGAAGTAGTGGAGCCGG

>16216_16216_2_CHCHD1-SUFU_CHCHD1_chr10_75542199_ENST00000372837_SUFU_chr10_104386932_ENST00000369902_length(amino acids)=181AA_BP=
MLPSHPPCIHSCPIFHSPLLIPLLSGILASRGPQPLTPSTADLTVCLPEASLSLAHGFGVPLGLSPTPDLEPASPFPAFLPPTLGMGLLQ
YFKITLYTSSKQSHDNAGLLIAPICLCCTHRHQQGCHRSAHRVQDSTDERSSQRAAPRGMRAPAGFSREQELDLHGATRPGLLYTSPGLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHCHD1-SUFU

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CHCHD1-SUFU

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CHCHD1-SUFU

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source