FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CHCHD6-MYO1A (FusionGDB2 ID:16256)

Fusion Gene Summary for CHCHD6-MYO1A

check button Fusion gene summary
Fusion gene informationFusion gene name: CHCHD6-MYO1A
Fusion gene ID: 16256
HgeneTgene
Gene symbol

CHCHD6

MYO1A

Gene ID

84303

4640

Gene namecoiled-coil-helix-coiled-coil-helix domain containing 6myosin IA
SynonymsCHCM1|MICOS25|Mic25|PPP1R23BBMI|DFNA48|MIHC|MYHL
Cytomap

3q21.3

12q13.3

Type of geneprotein-codingprotein-coding
DescriptionMICOS complex subunit MIC25coiled coil helix cristae morphology 1coiled-coil-helix cristae morphology protein 1coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrialmitochondrial contact site and cristae organizing system subununconventional myosin-Iabrush border myosin Imyosin I heavy chainmyosin, heavy polypeptide-like (100kD)myosin, heavy polypeptide-like 110kDa
Modification date2020032720200313
UniProtAcc

Q9BRQ6

Q9UBC5

Ensembl transtripts involved in fusion geneENST00000290913, ENST00000508789, 
ENST00000515867, 		ENST00000476795, 
ENST00000300119, ENST00000442789, 
ENST00000544473, 
Fusion gene scores* DoF score6 X 5 X 5=1501 X 1 X 1=1
# samples 61
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: CHCHD6 [Title/Abstract] AND MYO1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHCHD6(126499273)-MYO1A(57424958), # samples:1
CHCHD6(126452065)-MYO1A(57424958), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHCHD6

GO:0006974

cellular response to DNA damage stimulus

22228767


check buttonFusion gene breakpoints across CHCHD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A5UL-06ACHCHD6chr3

126452065

-MYO1Achr12

57424958

-
ChimerDB4SKCMTCGA-EB-A5UL-06ACHCHD6chr3

126499273

+MYO1Achr12

57424958

-


Top

Fusion Gene ORF analysis for CHCHD6-MYO1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000290913ENST00000476795CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
5CDS-intronENST00000508789ENST00000476795CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
In-frameENST00000290913ENST00000300119CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
In-frameENST00000290913ENST00000442789CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
In-frameENST00000290913ENST00000544473CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
In-frameENST00000508789ENST00000300119CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
In-frameENST00000508789ENST00000442789CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
In-frameENST00000508789ENST00000544473CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
intron-3CDSENST00000290913ENST00000300119CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000290913ENST00000442789CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000290913ENST00000544473CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000508789ENST00000300119CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000508789ENST00000442789CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000508789ENST00000544473CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000515867ENST00000300119CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
intron-3CDSENST00000515867ENST00000300119CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000515867ENST00000442789CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
intron-3CDSENST00000515867ENST00000442789CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-3CDSENST00000515867ENST00000544473CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
intron-3CDSENST00000515867ENST00000544473CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-intronENST00000290913ENST00000476795CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-intronENST00000508789ENST00000476795CHCHD6chr3

126499273

+MYO1Achr12

57424958

-
intron-intronENST00000515867ENST00000476795CHCHD6chr3

126452065

-MYO1Achr12

57424958

-
intron-intronENST00000515867ENST00000476795CHCHD6chr3

126499273

+MYO1Achr12

57424958

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290913CHCHD6chr3126452065-ENST00000300119MYO1Achr1257424958-1525504691286405
ENST00000290913CHCHD6chr3126452065-ENST00000442789MYO1Achr1257424958-1525504691286405
ENST00000290913CHCHD6chr3126452065-ENST00000544473MYO1Achr1257424958-1424504691286405
ENST00000508789CHCHD6chr3126452065-ENST00000300119MYO1Achr1257424958-1504483481265405
ENST00000508789CHCHD6chr3126452065-ENST00000442789MYO1Achr1257424958-1504483481265405
ENST00000508789CHCHD6chr3126452065-ENST00000544473MYO1Achr1257424958-1403483481265405

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290913ENST00000300119CHCHD6chr3126452065-MYO1Achr1257424958-0.0120958040.98790425
ENST00000290913ENST00000442789CHCHD6chr3126452065-MYO1Achr1257424958-0.0120958040.98790425
ENST00000290913ENST00000544473CHCHD6chr3126452065-MYO1Achr1257424958-0.013749640.9862504
ENST00000508789ENST00000300119CHCHD6chr3126452065-MYO1Achr1257424958-0.012335160.9876649
ENST00000508789ENST00000442789CHCHD6chr3126452065-MYO1Achr1257424958-0.012335160.9876649
ENST00000508789ENST00000544473CHCHD6chr3126452065-MYO1Achr1257424958-0.0141403380.9858597

Top

Fusion Genomic Features for CHCHD6-MYO1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CHCHD6-MYO1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:126499273/chr12:57424958)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHCHD6

Q9BRQ6

MYO1A

Q9UBC5

FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22228767}.FUNCTION: Involved in directing the movement of organelles along actin filaments. {ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO1Achr3:126452065chr12:57424958ENST000003001192128858_10427831044.0DomainTH1
TgeneMYO1Achr3:126452065chr12:57424958ENST000004427892229858_10427831044.0DomainTH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHCHD6chr3:126452065chr12:57424958ENST00000290913-48129_176137236.0Coiled coilOntology_term=ECO:0000255
HgeneCHCHD6chr3:126452065chr12:57424958ENST00000290913-48194_235137236.0DomainCHCH
HgeneCHCHD6chr3:126452065chr12:57424958ENST00000290913-48197_207137236.0MotifCx9C motif 1
HgeneCHCHD6chr3:126452065chr12:57424958ENST00000290913-48218_228137236.0MotifCx9C motif 2
TgeneMYO1Achr3:126452065chr12:57424958ENST000003001192128697_7197831044.0DomainIQ 1
TgeneMYO1Achr3:126452065chr12:57424958ENST000003001192128720_7427831044.0DomainIQ 2
TgeneMYO1Achr3:126452065chr12:57424958ENST000003001192128743_7727831044.0DomainIQ 3
TgeneMYO1Achr3:126452065chr12:57424958ENST0000030011921288_6947831044.0DomainMyosin motor
TgeneMYO1Achr3:126452065chr12:57424958ENST000004427892229697_7197831044.0DomainIQ 1
TgeneMYO1Achr3:126452065chr12:57424958ENST000004427892229720_7427831044.0DomainIQ 2
TgeneMYO1Achr3:126452065chr12:57424958ENST000004427892229743_7727831044.0DomainIQ 3
TgeneMYO1Achr3:126452065chr12:57424958ENST0000044278922298_6947831044.0DomainMyosin motor
TgeneMYO1Achr3:126452065chr12:57424958ENST000003001192128101_1087831044.0Nucleotide bindingATP
TgeneMYO1Achr3:126452065chr12:57424958ENST000004427892229101_1087831044.0Nucleotide bindingATP
TgeneMYO1Achr3:126452065chr12:57424958ENST000003001192128571_5937831044.0RegionActin-binding
TgeneMYO1Achr3:126452065chr12:57424958ENST000004427892229571_5937831044.0RegionActin-binding


Top

Fusion Gene Sequence for CHCHD6-MYO1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16256_16256_1_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000290913_MYO1A_chr12_57424958_ENST00000300119_length(transcript)=1525nt_BP=504nt
CGCGGCCGCGCGAGTCCTGGAAAGCGTTGTTGGCCCGGTTGCTCTGGAGCCGGGTCTCGGGTCTGGTGGCTGCCGGCCCTGCGGCATCTC
GCCATGGGGAGCACGGAGAGCAGCGAGGGCCGCAGGGTGTCCTTCGGAGTGGACGAGGAGGAGCGGGTCCGGGTGCTGCAGGGTGTCCGG
CTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCTTCTACCTTTGGCCTTCAAGATGGCAAC
TTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCCTCAGGGATGAAGGAGGGTGTCAAGAGG
TATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAGGCTGCCACCAAGCACTCCAAGGCATCC
CTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGTACAGAAATTCCTACTGGGGCTGAAGAACAATTTG
CCATCCACAAACGTCTTAGACAAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTGCAGCAGCTCTTCTAC
CAGTGGAAGTGCAAGAGGTTCCGGGATCAGCTGTCCCCGAAGCAGGTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAG
GGCAAGAAGGCTTCATATCCCCAGAGTGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCCAAGCTGCAGAAGCTG
AAAGGCGGGGAGGAGGGGCCTGTTCTGATGGCAGAGGCCGTGAAGAAGGTCAATCGTGGCAATGGCAAGACTTCTTCTCGGATTCTCCTC
CTGACCAAGGGCCATGTGATTCTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTGGCTGGGGTGTCAGTC
ACCAGCCTCAAGGATGGGCTCTTTAGCTTGCATCTGAGTGAGATGTCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCAT
GTGATTGAACTGCTGACCAAAATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACTGAGAAGTTCTCAGTG
AGGTTCAAGGAGAACAGTGTGGCTGTCAAGGTCGTCCAGGGCCCTGCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGT
CATTGCTTGGAGGTGACTGTGCAGTGAGGAGGGGGCACCATGCAGAGATGGCAGTTGCTTCCTCCTGAACCAGCACTAATCCCCCTCTGC
CCTCCTGTGTGGGAGGATCTCTAACCCCTCTGATCGTGGCGCATGGCTTGGGGATTAAACTACCCTTGAAGAGGACCCTTGTCCCAAACC

>16256_16256_1_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000290913_MYO1A_chr12_57424958_ENST00000300119_length(amino acids)=405AA_BP=145
MPALRHLAMGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSG
MKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQ
ELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGK
TSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT

--------------------------------------------------------------
>16256_16256_2_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000290913_MYO1A_chr12_57424958_ENST00000442789_length(transcript)=1525nt_BP=504nt
CGCGGCCGCGCGAGTCCTGGAAAGCGTTGTTGGCCCGGTTGCTCTGGAGCCGGGTCTCGGGTCTGGTGGCTGCCGGCCCTGCGGCATCTC
GCCATGGGGAGCACGGAGAGCAGCGAGGGCCGCAGGGTGTCCTTCGGAGTGGACGAGGAGGAGCGGGTCCGGGTGCTGCAGGGTGTCCGG
CTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCTTCTACCTTTGGCCTTCAAGATGGCAAC
TTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCCTCAGGGATGAAGGAGGGTGTCAAGAGG
TATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAGGCTGCCACCAAGCACTCCAAGGCATCC
CTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGTACAGAAATTCCTACTGGGGCTGAAGAACAATTTG
CCATCCACAAACGTCTTAGACAAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTGCAGCAGCTCTTCTAC
CAGTGGAAGTGCAAGAGGTTCCGGGATCAGCTGTCCCCGAAGCAGGTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAG
GGCAAGAAGGCTTCATATCCCCAGAGTGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCCAAGCTGCAGAAGCTG
AAAGGCGGGGAGGAGGGGCCTGTTCTGATGGCAGAGGCCGTGAAGAAGGTCAATCGTGGCAATGGCAAGACTTCTTCTCGGATTCTCCTC
CTGACCAAGGGCCATGTGATTCTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTGGCTGGGGTGTCAGTC
ACCAGCCTCAAGGATGGGCTCTTTAGCTTGCATCTGAGTGAGATGTCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCAT
GTGATTGAACTGCTGACCAAAATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACTGAGAAGTTCTCAGTG
AGGTTCAAGGAGAACAGTGTGGCTGTCAAGGTCGTCCAGGGCCCTGCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGT
CATTGCTTGGAGGTGACTGTGCAGTGAGGAGGGGGCACCATGCAGAGATGGCAGTTGCTTCCTCCTGAACCAGCACTAATCCCCCTCTGC
CCTCCTGTGTGGGAGGATCTCTAACCCCTCTGATCGTGGCGCATGGCTTGGGGATTAAACTACCCTTGAAGAGGACCCTTGTCCCAAACC

>16256_16256_2_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000290913_MYO1A_chr12_57424958_ENST00000442789_length(amino acids)=405AA_BP=145
MPALRHLAMGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSG
MKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQ
ELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGK
TSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT

--------------------------------------------------------------
>16256_16256_3_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000290913_MYO1A_chr12_57424958_ENST00000544473_length(transcript)=1424nt_BP=504nt
CGCGGCCGCGCGAGTCCTGGAAAGCGTTGTTGGCCCGGTTGCTCTGGAGCCGGGTCTCGGGTCTGGTGGCTGCCGGCCCTGCGGCATCTC
GCCATGGGGAGCACGGAGAGCAGCGAGGGCCGCAGGGTGTCCTTCGGAGTGGACGAGGAGGAGCGGGTCCGGGTGCTGCAGGGTGTCCGG
CTGTCTGAAAACGTGGTGAACCGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCTTCTACCTTTGGCCTTCAAGATGGCAAC
TTGAGAGCCCCTCACAAAGAATCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCCTCAGGGATGAAGGAGGGTGTCAAGAGG
TATGAACAGGAGCATGCTGCTATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAGGCTGCCACCAAGCACTCCAAGGCATCC
CTGCCCACGGGCGAAGGCAGCATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGTACAGAAATTCCTACTGGGGCTGAAGAACAATTTG
CCATCCACAAACGTCTTAGACAAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTGCAGCAGCTCTTCTAC
CAGTGGAAGTGCAAGAGGTTCCGGGATCAGCTGTCCCCGAAGCAGGTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAG
GGCAAGAAGGCTTCATATCCCCAGAGTGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCCAAGCTGCAGAAGCTG
AAAGGCGGGGAGGAGGGGCCTGTTCTGATGGCAGAGGCCGTGAAGAAGGTCAATCGTGGCAATGGCAAGACTTCTTCTCGGATTCTCCTC
CTGACCAAGGGCCATGTGATTCTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTGGCTGGGGTGTCAGTC
ACCAGCCTCAAGGATGGGCTCTTTAGCTTGCATCTGAGTGAGATGTCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCAT
GTGATTGAACTGCTGACCAAAATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACTGAGAAGTTCTCAGTG
AGGTTCAAGGAGAACAGTGTGGCTGTCAAGGTCGTCCAGGGCCCTGCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGT
CATTGCTTGGAGGTGACTGTGCAGTGAGGAGGGGGCACCATGCAGAGATGGCAGTTGCTTCCTCCTGAACCAGCACTAATCCCCCTCTGC

>16256_16256_3_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000290913_MYO1A_chr12_57424958_ENST00000544473_length(amino acids)=405AA_BP=145
MPALRHLAMGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSG
MKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQ
ELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGK
TSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT

--------------------------------------------------------------
>16256_16256_4_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000508789_MYO1A_chr12_57424958_ENST00000300119_length(transcript)=1504nt_BP=483nt
AAGCGTTGTTGGCCCGGTTGCTCTGGAGCCGGGTCTCGGGTCTGGTGGCTGCCGGCCCTGCGGCATCTCGCCATGGGGAGCACGGAGAGC
AGCGAGGGCCGCAGGGTGTCCTTCGGAGTGGACGAGGAGGAGCGGGTCCGGGTGCTGCAGGGTGTCCGGCTGTCTGAAAACGTGGTGAAC
CGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCTTCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAA
TCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCCTCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCT
ATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAGGCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGC
ATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGTACAGAAATTCCTACTGGGGCTGAAGAACAATTTGCCATCCACAAACGTCTTAGAC
AAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTGCAGCAGCTCTTCTACCAGTGGAAGTGCAAGAGGTTC
CGGGATCAGCTGTCCCCGAAGCAGGTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAGGGCAAGAAGGCTTCATATCCC
CAGAGTGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCCAAGCTGCAGAAGCTGAAAGGCGGGGAGGAGGGGCCT
GTTCTGATGGCAGAGGCCGTGAAGAAGGTCAATCGTGGCAATGGCAAGACTTCTTCTCGGATTCTCCTCCTGACCAAGGGCCATGTGATT
CTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTGGCTGGGGTGTCAGTCACCAGCCTCAAGGATGGGCTC
TTTAGCTTGCATCTGAGTGAGATGTCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCATGTGATTGAACTGCTGACCAAA
ATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACTGAGAAGTTCTCAGTGAGGTTCAAGGAGAACAGTGTG
GCTGTCAAGGTCGTCCAGGGCCCTGCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGTCATTGCTTGGAGGTGACTGTG
CAGTGAGGAGGGGGCACCATGCAGAGATGGCAGTTGCTTCCTCCTGAACCAGCACTAATCCCCCTCTGCCCTCCTGTGTGGGAGGATCTC
TAACCCCTCTGATCGTGGCGCATGGCTTGGGGATTAAACTACCCTTGAAGAGGACCCTTGTCCCAAACCCTTCTTGTTCTCTCCTCCAAA

>16256_16256_4_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000508789_MYO1A_chr12_57424958_ENST00000300119_length(amino acids)=405AA_BP=145
MPALRHLAMGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSG
MKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQ
ELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGK
TSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT

--------------------------------------------------------------
>16256_16256_5_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000508789_MYO1A_chr12_57424958_ENST00000442789_length(transcript)=1504nt_BP=483nt
AAGCGTTGTTGGCCCGGTTGCTCTGGAGCCGGGTCTCGGGTCTGGTGGCTGCCGGCCCTGCGGCATCTCGCCATGGGGAGCACGGAGAGC
AGCGAGGGCCGCAGGGTGTCCTTCGGAGTGGACGAGGAGGAGCGGGTCCGGGTGCTGCAGGGTGTCCGGCTGTCTGAAAACGTGGTGAAC
CGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCTTCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAA
TCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCCTCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCT
ATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAGGCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGC
ATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGTACAGAAATTCCTACTGGGGCTGAAGAACAATTTGCCATCCACAAACGTCTTAGAC
AAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTGCAGCAGCTCTTCTACCAGTGGAAGTGCAAGAGGTTC
CGGGATCAGCTGTCCCCGAAGCAGGTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAGGGCAAGAAGGCTTCATATCCC
CAGAGTGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCCAAGCTGCAGAAGCTGAAAGGCGGGGAGGAGGGGCCT
GTTCTGATGGCAGAGGCCGTGAAGAAGGTCAATCGTGGCAATGGCAAGACTTCTTCTCGGATTCTCCTCCTGACCAAGGGCCATGTGATT
CTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTGGCTGGGGTGTCAGTCACCAGCCTCAAGGATGGGCTC
TTTAGCTTGCATCTGAGTGAGATGTCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCATGTGATTGAACTGCTGACCAAA
ATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACTGAGAAGTTCTCAGTGAGGTTCAAGGAGAACAGTGTG
GCTGTCAAGGTCGTCCAGGGCCCTGCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGTCATTGCTTGGAGGTGACTGTG
CAGTGAGGAGGGGGCACCATGCAGAGATGGCAGTTGCTTCCTCCTGAACCAGCACTAATCCCCCTCTGCCCTCCTGTGTGGGAGGATCTC
TAACCCCTCTGATCGTGGCGCATGGCTTGGGGATTAAACTACCCTTGAAGAGGACCCTTGTCCCAAACCCTTCTTGTTCTCTCCTCCAAA

>16256_16256_5_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000508789_MYO1A_chr12_57424958_ENST00000442789_length(amino acids)=405AA_BP=145
MPALRHLAMGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSG
MKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQ
ELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGK
TSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT

--------------------------------------------------------------
>16256_16256_6_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000508789_MYO1A_chr12_57424958_ENST00000544473_length(transcript)=1403nt_BP=483nt
AAGCGTTGTTGGCCCGGTTGCTCTGGAGCCGGGTCTCGGGTCTGGTGGCTGCCGGCCCTGCGGCATCTCGCCATGGGGAGCACGGAGAGC
AGCGAGGGCCGCAGGGTGTCCTTCGGAGTGGACGAGGAGGAGCGGGTCCGGGTGCTGCAGGGTGTCCGGCTGTCTGAAAACGTGGTGAAC
CGCATGAAGGAGCCCAGCTCTCCACCCCCTGCTCCCACATCTTCTACCTTTGGCCTTCAAGATGGCAACTTGAGAGCCCCTCACAAAGAA
TCCACACTGCCCAGGTCGGGGAGCAGTGGTGGCCAGCAGCCCTCAGGGATGAAGGAGGGTGTCAAGAGGTATGAACAGGAGCATGCTGCT
ATCCAGGATAAGCTCTTCCAGGTGGCAAAGAGGGAAAGAGAGGCTGCCACCAAGCACTCCAAGGCATCCCTGCCCACGGGCGAAGGCAGC
ATCAGCCATGAGGAGCAGAAGTCAGTCCGGCTGGTACAGAAATTCCTACTGGGGCTGAAGAACAATTTGCCATCCACAAACGTCTTAGAC
AAGACATGGCCAGCCGCCCCCTACAAGTGCCTCAGCACAGCAAATCAGGAGCTGCAGCAGCTCTTCTACCAGTGGAAGTGCAAGAGGTTC
CGGGATCAGCTGTCCCCGAAGCAGGTAGAGATCCTGAGGGAAAAGCTCTGTGCCAGTGAACTGTTCAAGGGCAAGAAGGCTTCATATCCC
CAGAGTGTCCCCATTCCATTCTGTGGTGACTACATTGGGCTGCAAGGGAACCCCAAGCTGCAGAAGCTGAAAGGCGGGGAGGAGGGGCCT
GTTCTGATGGCAGAGGCCGTGAAGAAGGTCAATCGTGGCAATGGCAAGACTTCTTCTCGGATTCTCCTCCTGACCAAGGGCCATGTGATT
CTCACAGACACCAAGAAGTCCCAGGCCAAAATTGTCATTGGGCTAGACAATGTGGCTGGGGTGTCAGTCACCAGCCTCAAGGATGGGCTC
TTTAGCTTGCATCTGAGTGAGATGTCATCGGTGGGCTCCAAGGGGGACTTCCTGCTGGTCAGCGAGCATGTGATTGAACTGCTGACCAAA
ATGTACCGGGCTGTGCTGGATGCCACGCAGAGGCAGCTTACAGTCACCGTGACTGAGAAGTTCTCAGTGAGGTTCAAGGAGAACAGTGTG
GCTGTCAAGGTCGTCCAGGGCCCTGCAGGTGGTGACAACAGCAAGCTACGCTACAAAAAAAAGGGGAGTCATTGCTTGGAGGTGACTGTG
CAGTGAGGAGGGGGCACCATGCAGAGATGGCAGTTGCTTCCTCCTGAACCAGCACTAATCCCCCTCTGCCCTCCTGTGTGGGAGGATCTC

>16256_16256_6_CHCHD6-MYO1A_CHCHD6_chr3_126452065_ENST00000508789_MYO1A_chr12_57424958_ENST00000544473_length(amino acids)=405AA_BP=145
MPALRHLAMGSTESSEGRRVSFGVDEEERVRVLQGVRLSENVVNRMKEPSSPPPAPTSSTFGLQDGNLRAPHKESTLPRSGSSGGQQPSG
MKEGVKRYEQEHAAIQDKLFQVAKREREAATKHSKASLPTGEGSISHEEQKSVRLVQKFLLGLKNNLPSTNVLDKTWPAAPYKCLSTANQ
ELQQLFYQWKCKRFRDQLSPKQVEILREKLCASELFKGKKASYPQSVPIPFCGDYIGLQGNPKLQKLKGGEEGPVLMAEAVKKVNRGNGK
TSSRILLLTKGHVILTDTKKSQAKIVIGLDNVAGVSVTSLKDGLFSLHLSEMSSVGSKGDFLLVSEHVIELLTKMYRAVLDATQRQLTVT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CHCHD6-MYO1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CHCHD6-MYO1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CHCHD6-MYO1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource