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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHD2-OTUD5 (FusionGDB2 ID:16305)

Fusion Gene Summary for CHD2-OTUD5

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD2-OTUD5
Fusion gene ID: 16305
HgeneTgene
Gene symbol

CHD2

OTUD5

Gene ID

1826

55593

Gene nameDS cell adhesion moleculeOTU deubiquitinase 5
SynonymsCHD2|CHD2-42|CHD2-52DUBA
Cytomap

21q22.2

Xp11.23

Type of geneprotein-codingprotein-coding
DescriptionDown syndrome cell adhesion moleculeOTU domain-containing protein 5OTU domain containing 5deubiquinating enzyme Adeubiquitinating enzyme A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000394196, ENST00000557381, 
ENST00000420239, ENST00000536619, 
ENST00000554122, 		ENST00000484499, 
ENST00000156084, ENST00000428668, 
ENST00000376488, ENST00000396743, 
Fusion gene scores* DoF score22 X 13 X 11=31467 X 7 X 1=49
# samples 237
** MAII scorelog2(23/3146*10)=-3.77381290447131
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/49*10)=0.514573172829758
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CHD2 [Title/Abstract] AND OTUD5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHD2(93540196)-OTUD5(48780479), # samples:1
Anticipated loss of major functional domain due to fusion event.CHD2-OTUD5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CHD2-OTUD5 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CHD2-OTUD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CHD2-OTUD5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHD2

GO:0042327

positive regulation of phosphorylation

19196994

HgeneCHD2

GO:0048842

positive regulation of axon extension involved in axon guidance

18585357

TgeneOTUD5

GO:0016579

protein deubiquitination

22245969

TgeneOTUD5

GO:0032496

response to lipopolysaccharide

22245969

TgeneOTUD5

GO:0070536

protein K63-linked deubiquitination

22245969|23827681

TgeneOTUD5

GO:0071108

protein K48-linked deubiquitination

22245969|23827681


check buttonFusion gene breakpoints across CHD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OTUD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF852660CHD2chr15

93540196

-OTUD5chrX

48780479

+


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Fusion Gene ORF analysis for CHD2-OTUD5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394196ENST00000484499CHD2chr15

93540196

-OTUD5chrX

48780479

+
5CDS-intronENST00000557381ENST00000484499CHD2chr15

93540196

-OTUD5chrX

48780479

+
Frame-shiftENST00000394196ENST00000156084CHD2chr15

93540196

-OTUD5chrX

48780479

+
Frame-shiftENST00000394196ENST00000428668CHD2chr15

93540196

-OTUD5chrX

48780479

+
Frame-shiftENST00000557381ENST00000156084CHD2chr15

93540196

-OTUD5chrX

48780479

+
Frame-shiftENST00000557381ENST00000428668CHD2chr15

93540196

-OTUD5chrX

48780479

+
In-frameENST00000394196ENST00000376488CHD2chr15

93540196

-OTUD5chrX

48780479

+
In-frameENST00000394196ENST00000396743CHD2chr15

93540196

-OTUD5chrX

48780479

+
In-frameENST00000557381ENST00000376488CHD2chr15

93540196

-OTUD5chrX

48780479

+
In-frameENST00000557381ENST00000396743CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000420239ENST00000156084CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000420239ENST00000376488CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000420239ENST00000396743CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000420239ENST00000428668CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000536619ENST00000156084CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000536619ENST00000376488CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000536619ENST00000396743CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000536619ENST00000428668CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000554122ENST00000156084CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000554122ENST00000376488CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000554122ENST00000396743CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-3CDSENST00000554122ENST00000428668CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-intronENST00000420239ENST00000484499CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-intronENST00000536619ENST00000484499CHD2chr15

93540196

-OTUD5chrX

48780479

+
intron-intronENST00000554122ENST00000484499CHD2chr15

93540196

-OTUD5chrX

48780479

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394196CHD2chr1593540196-ENST00000396743OTUD5chrX48780479+57414792106847151215
ENST00000394196CHD2chr1593540196-ENST00000376488OTUD5chrX48780479+57834792106847151215
ENST00000557381CHD2chr1593540196-ENST00000396743OTUD5chrX48780479+5380443170743541215
ENST00000557381CHD2chr1593540196-ENST00000376488OTUD5chrX48780479+5422443170743541215

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394196ENST00000396743CHD2chr1593540196-OTUD5chrX48780479+0.0010357160.9989643
ENST00000394196ENST00000376488CHD2chr1593540196-OTUD5chrX48780479+0.0011285160.9988715
ENST00000557381ENST00000396743CHD2chr1593540196-OTUD5chrX48780479+0.0009858510.99901414
ENST00000557381ENST00000376488CHD2chr1593540196-OTUD5chrX48780479+0.0010695670.9989304

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Fusion Genomic Features for CHD2-OTUD5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHD2-OTUD5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:93540196/chrX:48780479)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneOTUD5chr15:93540196chrX:48780479ENST000001560840933_1740572.0Compositional biasNote=Gly-rich
TgeneOTUD5chr15:93540196chrX:48780479ENST00000156084095_1130572.0Compositional biasNote=Pro-rich
TgeneOTUD5chr15:93540196chrX:48780479ENST000004286680933_1740350.0Compositional biasNote=Gly-rich
TgeneOTUD5chr15:93540196chrX:48780479ENST00000428668095_1130350.0Compositional biasNote=Pro-rich
TgeneOTUD5chr15:93540196chrX:48780479ENST0000015608409213_3410572.0DomainOTU
TgeneOTUD5chr15:93540196chrX:48780479ENST0000042866809213_3410350.0DomainOTU
TgeneOTUD5chr15:93540196chrX:48780479ENST0000015608409218_2240572.0RegionCys-loop
TgeneOTUD5chr15:93540196chrX:48780479ENST0000015608409273_2830572.0RegionVariable-loop
TgeneOTUD5chr15:93540196chrX:48780479ENST0000015608409329_3340572.0RegionHis-loop
TgeneOTUD5chr15:93540196chrX:48780479ENST0000042866809218_2240350.0RegionCys-loop
TgeneOTUD5chr15:93540196chrX:48780479ENST0000042866809273_2830350.0RegionVariable-loop
TgeneOTUD5chr15:93540196chrX:48780479ENST0000042866809329_3340350.0RegionHis-loop

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139121_13901829.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-13913_7401829.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139966_106601829.0Compositional biasNote=Glu-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113121_1390502.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-11313_740502.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113966_10660502.0Compositional biasNote=Glu-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138121_13901740.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-13813_7401740.0Compositional biasNote=Ser-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138966_106601740.0Compositional biasNote=Glu-rich
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139261_35301829.0DomainChromo 1
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139378_45601829.0DomainChromo 2
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139496_66601829.0DomainHelicase ATP-binding
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139795_94601829.0DomainHelicase C-terminal
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113261_3530502.0DomainChromo 1
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113378_4560502.0DomainChromo 2
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113496_6660502.0DomainHelicase ATP-binding
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113795_9460502.0DomainHelicase C-terminal
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138261_35301740.0DomainChromo 1
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138378_45601740.0DomainChromo 2
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138496_66601740.0DomainHelicase ATP-binding
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138795_94601740.0DomainHelicase C-terminal
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139617_62001829.0MotifNote=DEAH box
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113617_6200502.0MotifNote=DEAH box
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138617_62001740.0MotifNote=DEAH box
HgeneCHD2chr15:93540196chrX:48780479ENST00000394196-139509_51601829.0Nucleotide bindingATP
HgeneCHD2chr15:93540196chrX:48780479ENST00000420239-113509_5160502.0Nucleotide bindingATP
HgeneCHD2chr15:93540196chrX:48780479ENST00000557381-138509_51601740.0Nucleotide bindingATP


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Fusion Gene Sequence for CHD2-OTUD5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16305_16305_1_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000394196_OTUD5_chrX_48780479_ENST00000376488_length(transcript)=5783nt_BP=4792nt
TAAAGAAGGAAAAACTTGAATTTATATTATGAAATTAAGGTTTTACTTTTATTTAGCAATCATTTCACCCATTGGGGGATTAATTTTTAA
AAAGATTAGTACTTAGCTGAGCTTTAGATTCTCTAAGAATTATCCCTTTTTCAAAATGGCTTGATAAAACACCACTTCCTGTCCAGGGAG
GAAGTTATTTTAGCTCAAGGACTGAAATATTTAGCAGATCTTTAGACAAAAGGAACAAATTACATTTCTCTCTGGCTTAAAAAGGGTGCT
TGAGCCAGAGGGGGTTAAGAAGCCCTCCCCCCTCCCCCTGTTGGGGTGGTCTGGAGGGGCAGGGAGGTGTGGGGGTGGGGGTCCTTAGGC
TCCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTG
AGTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAG
AGCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTT
TCCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAG
CAGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTT
TTTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTT
TTAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACAT
GGATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAAT
AAGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGC
AGTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCG
GAATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCT
GATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATT
AAGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAA
CCCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGA
ACAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGAT
GACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGAT
CTCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAA
GGAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAA
ATCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGC
CTAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAAT
TGCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGT
CAAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAG
TGTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCA
ACAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTT
CGAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGA
AAGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACC
CTCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGATA
CGGGAATATGAATGGATTCATTCCCAAACCAAAAGATTGAAGTTCAACGCACTTATAACAACATATGAGATCCTCTTGAAAGATAAGACT
GTGCTGGGCAGTATTAACTGGGCCTTTCTGGGAGTGGATGAAGCCCATCGGTTGAAGAATGATGACTCTTTATTGTATAAAACTCTGATT
GATTTCAAGTCCAACCATAGGCTCCTGATTACGGGGACCCCTCTTCAGAATTCCCTCAAAGAGCTCTGGTCCTTGCTGCACTTTATTATG
CCGGAGAAGTTTGAATTTTGGGAAGATTTTGAAGAAGACCATGGGAAGGGGAGAGAAAATGGCTACCAGAGTCTTCATAAGGTGCTAGAG
CCTTTCCTTCTCCGGAGAGTCAAAAAAGATGTGGAGAAATCCCTTCCTGCTAAAGTGGAACAGATTCTCAGGGTGGAGATGTCAGCCCTT
CAGAAACAGTATTACAAGTGGATTCTGACCAGGAATTACAAGGCTCTTGCCAAAGGAACAAGAGGCAGCACATCTGGTTTTCTTAATATT
GTGATGGAACTGAAAAAATGTTGCAACCACTGCTATCTGATTAAACCCCCTGAAGAAAATGAAAGGGAAAATGGACAGGAGATTCTTCTG
TCCCTCATAAGGAGCAGTGGGAAGTTGATTTTATTAGACAAACTGTTGACAAGACTTCGAGAAAGGGGGAATCGAGTGCTTATCTTCTCT
CAGATGGTGAGAATGTTGGATATCCTGGCTGAATACCTAACTATTAAACACTATCCTTTCCAGCGTCTGGATGGTTCCATCAAGGGAGAA
ATCCGAAAACAGGCACTGGACCACTTCAATGCAGATGGGTCTGAGGACTTCTGTTTCCTGCTCTCGACAAGGGCTGGTGGCCTGGGAATC
AATTTGGCTTCAGCGGACACAGTCGTCATCTTTGACTCTGACTGGAACCCCCAGAATGACTTGCAGGCACAAGCCCGAGCGCATAGAATT
GGTCAAAAGAAGCAGGTAAATATTTACCGCTTAGTTACAAAGGGGACTGTGGAGGAGGAGATCATAGAACGGGCCAAAAAGAAGATGGTA
TTAGATCATCTGGTGATTCAGCGCATGGACACCACTGGCCGGACGATCCTGGAAAACAACTCAGGAAGGTCCAACTCAAATCCTTTTAAT
AAAGAAGAGCTGACAGCTATTTTGAAATTTGGAGCAGAGGATCTCTTCAAAGAACTGGAAGGGGAGGAATCAGAACCTCAGGAAATGGAT
ATAGATGAAATTTTGCGGTTGGCTGAAACGAGAGAGAATGAAGTGTCAACAAGTGCAACAGATGAACTTCTATCACAGTTTAAGGTTGCC
AACTTTGCAACAATGGAAGATGAAGAAGAGCTAGAAGAGCGTCCTCACAAGGACTGGGATGAGATCATTCCAGAGGAACAAAGGAAAAAA
GTAGAGGAGGAAGAGCGGCAGAAGGAGCTAGAAGAAATTTATATGCTGCCTCGAATTCGGAGTTCCACTAAAAAGGCTCAGACAAATGAC
AGTGACTCTGACACTGAGTCTAAGAGGCAGGCCCAGAGATCCTCTGCTTCTGAGAGTGAAACGGAAGACTCTGATGATGACAAGAAGCCA
AAGCGCAGAGGGCGTCCGAGGAGTGTGCGGAAGGACCTCGTGGAGGGATTTACTGATGCAGAGATCCGAAGGTTCATCAAGGCTTATAAG
AAGTTTGGTCTCCCTCTTGAACGGCTGGAGTGCATAGCACGTGATGCTGAGCTGGTAGATAAGTCGGTGGCAGATCTGAAGCGCCTGGGT
GAACTGATCCACAACAGCTGTGTGTCAGCAATGCAGGAATACGAAGAGCAGCTGAAAGAAAATGCCAGCGAGGAGGGAAAAGGAGAGGTC
CAACAATCAAGATATCCGGAGTTCAGGTTAATGTGAAATCCATTATCCAACATGAAGAGGAGTTTGAGATGCTGCATAAATCTATCCCTG
TGGACCCTGAAGAAAAAAAAAAACAGAGACCCGCCCCCAGACAAGAGTTGATGGAGACCCAGGGATTGGACACCATCTCCCAACCCCAGT
ACTCCTGCTCTCCGGTGCCACCTCACCTTCTTTGGCTTCTTCCCTCTTGCCTCCTTCTGTTCTTTCTGCTCTCCCCTCTTTTCCCTCCTC
CTCACTTCCCTCTGGCTAGCCCACCCCTGCACTCTCTCTCATTGCCGCTGCCACTATCACCTGTCTCTCTGCCAGCTGATGTGCCCTGTT
GCCCCCCACCCCATCCCGCACAGAACCATCCCTGCATTCCACAGGGGACTCGGGCAAGGGTGCCGAAGATAGACAAGAGGCACACAGAGA
CAGACCAACTGGCAGCCAGGCAGCCCCAGAGGAGAGAGACATTCAGACAGAGGAAAGTCTCCCTGCCCCTCATTCCTTCCAAGATGAGAA
AAACTTGCCGCCACCCCCCGACACTGATGCCAGGGAGGTGGGAGGAAGAAGTGGGAAATTTCCCTTCCCAGTACCCCCAAGAACGTCTGA
GCCTTCAATGTTGAATTTTTTCTTTATTAAAATTACTTTTATCTTATAAAATCAACTAATCAAAAATGATATAGACGACAGCACTGGCTC
TGTGAAGGTGGCATCTTTCTGGGCAGGCAGGCCATGGGGCATGGAGGAGGGTGCAAAGATATGGGTTGCTGTCTTCTGGCCTCCAGCTGC
ATGGAGGCCGGCCCAGGGTCTAGGGTGTGCACTGGGCAAGGGCAGGGCGGCAGGTGTCAGGCCGGCTTGGACAATGAAACCCTGACCTTG
CTGCATTCCTTTTGCTTCCACCACCACTAGCTTCTTTGGAATCTTGGGGTGGGGGTCATCTTTGGGGATTATGGCTGCCACCCGGGATTT
GAGTGTAGGGAGTGTGGGAGCAGCCTTGGCAGATGGGGCACCCGTGCCCTGCAGGTGTTGACAAGATCCGCCATCTGTAATGTCCTTGGC

>16305_16305_1_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000394196_OTUD5_chrX_48780479_ENST00000376488_length(amino acids)=1215AA_BP=
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLY
KTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVE
MSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRV
LIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQAR
AHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEP
QEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKA
QTNDSDSDTESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADL

--------------------------------------------------------------
>16305_16305_2_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000394196_OTUD5_chrX_48780479_ENST00000396743_length(transcript)=5741nt_BP=4792nt
TAAAGAAGGAAAAACTTGAATTTATATTATGAAATTAAGGTTTTACTTTTATTTAGCAATCATTTCACCCATTGGGGGATTAATTTTTAA
AAAGATTAGTACTTAGCTGAGCTTTAGATTCTCTAAGAATTATCCCTTTTTCAAAATGGCTTGATAAAACACCACTTCCTGTCCAGGGAG
GAAGTTATTTTAGCTCAAGGACTGAAATATTTAGCAGATCTTTAGACAAAAGGAACAAATTACATTTCTCTCTGGCTTAAAAAGGGTGCT
TGAGCCAGAGGGGGTTAAGAAGCCCTCCCCCCTCCCCCTGTTGGGGTGGTCTGGAGGGGCAGGGAGGTGTGGGGGTGGGGGTCCTTAGGC
TCCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTG
AGTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAG
AGCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTT
TCCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAG
CAGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTT
TTTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTT
TTAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACAT
GGATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAAT
AAGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGC
AGTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCG
GAATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCT
GATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATT
AAGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAA
CCCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGA
ACAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGAT
GACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGAT
CTCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAA
GGAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAA
ATCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGC
CTAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAAT
TGCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGT
CAAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAG
TGTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCA
ACAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTT
CGAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGA
AAGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACC
CTCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGATA
CGGGAATATGAATGGATTCATTCCCAAACCAAAAGATTGAAGTTCAACGCACTTATAACAACATATGAGATCCTCTTGAAAGATAAGACT
GTGCTGGGCAGTATTAACTGGGCCTTTCTGGGAGTGGATGAAGCCCATCGGTTGAAGAATGATGACTCTTTATTGTATAAAACTCTGATT
GATTTCAAGTCCAACCATAGGCTCCTGATTACGGGGACCCCTCTTCAGAATTCCCTCAAAGAGCTCTGGTCCTTGCTGCACTTTATTATG
CCGGAGAAGTTTGAATTTTGGGAAGATTTTGAAGAAGACCATGGGAAGGGGAGAGAAAATGGCTACCAGAGTCTTCATAAGGTGCTAGAG
CCTTTCCTTCTCCGGAGAGTCAAAAAAGATGTGGAGAAATCCCTTCCTGCTAAAGTGGAACAGATTCTCAGGGTGGAGATGTCAGCCCTT
CAGAAACAGTATTACAAGTGGATTCTGACCAGGAATTACAAGGCTCTTGCCAAAGGAACAAGAGGCAGCACATCTGGTTTTCTTAATATT
GTGATGGAACTGAAAAAATGTTGCAACCACTGCTATCTGATTAAACCCCCTGAAGAAAATGAAAGGGAAAATGGACAGGAGATTCTTCTG
TCCCTCATAAGGAGCAGTGGGAAGTTGATTTTATTAGACAAACTGTTGACAAGACTTCGAGAAAGGGGGAATCGAGTGCTTATCTTCTCT
CAGATGGTGAGAATGTTGGATATCCTGGCTGAATACCTAACTATTAAACACTATCCTTTCCAGCGTCTGGATGGTTCCATCAAGGGAGAA
ATCCGAAAACAGGCACTGGACCACTTCAATGCAGATGGGTCTGAGGACTTCTGTTTCCTGCTCTCGACAAGGGCTGGTGGCCTGGGAATC
AATTTGGCTTCAGCGGACACAGTCGTCATCTTTGACTCTGACTGGAACCCCCAGAATGACTTGCAGGCACAAGCCCGAGCGCATAGAATT
GGTCAAAAGAAGCAGGTAAATATTTACCGCTTAGTTACAAAGGGGACTGTGGAGGAGGAGATCATAGAACGGGCCAAAAAGAAGATGGTA
TTAGATCATCTGGTGATTCAGCGCATGGACACCACTGGCCGGACGATCCTGGAAAACAACTCAGGAAGGTCCAACTCAAATCCTTTTAAT
AAAGAAGAGCTGACAGCTATTTTGAAATTTGGAGCAGAGGATCTCTTCAAAGAACTGGAAGGGGAGGAATCAGAACCTCAGGAAATGGAT
ATAGATGAAATTTTGCGGTTGGCTGAAACGAGAGAGAATGAAGTGTCAACAAGTGCAACAGATGAACTTCTATCACAGTTTAAGGTTGCC
AACTTTGCAACAATGGAAGATGAAGAAGAGCTAGAAGAGCGTCCTCACAAGGACTGGGATGAGATCATTCCAGAGGAACAAAGGAAAAAA
GTAGAGGAGGAAGAGCGGCAGAAGGAGCTAGAAGAAATTTATATGCTGCCTCGAATTCGGAGTTCCACTAAAAAGGCTCAGACAAATGAC
AGTGACTCTGACACTGAGTCTAAGAGGCAGGCCCAGAGATCCTCTGCTTCTGAGAGTGAAACGGAAGACTCTGATGATGACAAGAAGCCA
AAGCGCAGAGGGCGTCCGAGGAGTGTGCGGAAGGACCTCGTGGAGGGATTTACTGATGCAGAGATCCGAAGGTTCATCAAGGCTTATAAG
AAGTTTGGTCTCCCTCTTGAACGGCTGGAGTGCATAGCACGTGATGCTGAGCTGGTAGATAAGTCGGTGGCAGATCTGAAGCGCCTGGGT
GAACTGATCCACAACAGCTGTGTGTCAGCAATGCAGGAATACGAAGAGCAGCTGAAAGAAAATGCCAGCGAGGAGGGAAAAGGAGAGGTC
CAACAATCAAGATATCCGGAGTTCAGGTTAATGTGAAATCCATTATCCAACATGAAGAGGAGTTTGAGATGCTGCATAAATCTATCCCTG
TGGACCCTGAAGAAAAAAAAAAGGGACTCGGGCAAGGGTGCCGAAGATAGACAAGAGGCACACAGAGACAGACCAACTGGCAGCCAGGCA
GCCCCAGAGGAGAGAGACATTCAGACAGAGGAAAGTCTCCCTGCCCCTCATTCCTTCCAAGATGAGAAAAACTTGCCGCCACCCCCCGAC
ACTGATGCCAGGGAGGTGGGAGGAAGAAGTGGGAAATTTCCCTTCCCAGTACCCCCAAGAACGTCTGAGCCTTCAATGTTGAATTTTTTC
TTTATTAAAATTACTTTTATCTTATAAAATCAACTAATCAAAAATGATATAGACGACAGCACTGGCTCTGTGAAGGTGGCATCTTTCTGG
GCAGGCAGGCCATGGGGCATGGAGGAGGGTGCAAAGATATGGGTTGCTGTCTTCTGGCCTCCAGCTGCATGGAGGCCGGCCCAGGGTCTA
GGGTGTGCACTGGGCAAGGGCAGGGCGGCAGGTGTCAGGCCGGCTTGGACAATGAAACCCTGACCTTGCTGCATTCCTTTTGCTTCCACC
ACCACTAGCTTCTTTGGAATCTTGGGGTGGGGGTCATCTTTGGGGATTATGGCTGCCACCCGGGATTTGAGTGTAGGGAGTGTGGGAGCA
GCCTTGGCAGATGGGGCACCCGTGCCCTGCAGGTGTTGACAAGATCCGCCATCTGTAATGTCCTTGGCACAATAAAACCAAATGTCAGTT
TCCCTGAGCGACTCTGTTCTGTGTGGGGCAGGGGTTGGGCGGGCCTCTGGGCAGAGGATGCAATGGCACGGACCTTGGCTTGACCTCAGA
GGTGTGAATGCTCTCCAGCAGGGTCTGTCTGGGGGCCTGGAGTTTGTATTTGATTTGCTGCTTATTAAACCTCCTTCTGGACCTATTGCC

>16305_16305_2_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000394196_OTUD5_chrX_48780479_ENST00000396743_length(amino acids)=1215AA_BP=
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLY
KTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVE
MSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRV
LIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQAR
AHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEP
QEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKA
QTNDSDSDTESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADL

--------------------------------------------------------------
>16305_16305_3_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000557381_OTUD5_chrX_48780479_ENST00000376488_length(transcript)=5422nt_BP=4431nt
CCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTGA
GTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAGA
GCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTTT
CCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAGC
AGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTTT
TTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTTT
TAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACATG
GATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAATA
AGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGCA
GTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCGG
AATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCTG
ATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATTA
AGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAAC
CCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGAA
CAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGATG
ACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGATC
TCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAAG
GAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAAA
TCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGCC
TAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAATT
GCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGTC
AAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAGT
GTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCAA
CAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTTC
GAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGAA
AGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACCC
TCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGATAC
GGGAATATGAATGGATTCATTCCCAAACCAAAAGATTGAAGTTCAACGCACTTATAACAACATATGAGATCCTCTTGAAAGATAAGACTG
TGCTGGGCAGTATTAACTGGGCCTTTCTGGGAGTGGATGAAGCCCATCGGTTGAAGAATGATGACTCTTTATTGTATAAAACTCTGATTG
ATTTCAAGTCCAACCATAGGCTCCTGATTACGGGGACCCCTCTTCAGAATTCCCTCAAAGAGCTCTGGTCCTTGCTGCACTTTATTATGC
CGGAGAAGTTTGAATTTTGGGAAGATTTTGAAGAAGACCATGGGAAGGGGAGAGAAAATGGCTACCAGAGTCTTCATAAGGTGCTAGAGC
CTTTCCTTCTCCGGAGAGTCAAAAAAGATGTGGAGAAATCCCTTCCTGCTAAAGTGGAACAGATTCTCAGGGTGGAGATGTCAGCCCTTC
AGAAACAGTATTACAAGTGGATTCTGACCAGGAATTACAAGGCTCTTGCCAAAGGAACAAGAGGCAGCACATCTGGTTTTCTTAATATTG
TGATGGAACTGAAAAAATGTTGCAACCACTGCTATCTGATTAAACCCCCTGAAGAAAATGAAAGGGAAAATGGACAGGAGATTCTTCTGT
CCCTCATAAGGAGCAGTGGGAAGTTGATTTTATTAGACAAACTGTTGACAAGACTTCGAGAAAGGGGGAATCGAGTGCTTATCTTCTCTC
AGATGGTGAGAATGTTGGATATCCTGGCTGAATACCTAACTATTAAACACTATCCTTTCCAGCGTCTGGATGGTTCCATCAAGGGAGAAA
TCCGAAAACAGGCACTGGACCACTTCAATGCAGATGGGTCTGAGGACTTCTGTTTCCTGCTCTCGACAAGGGCTGGTGGCCTGGGAATCA
ATTTGGCTTCAGCGGACACAGTCGTCATCTTTGACTCTGACTGGAACCCCCAGAATGACTTGCAGGCACAAGCCCGAGCGCATAGAATTG
GTCAAAAGAAGCAGGTAAATATTTACCGCTTAGTTACAAAGGGGACTGTGGAGGAGGAGATCATAGAACGGGCCAAAAAGAAGATGGTAT
TAGATCATCTGGTGATTCAGCGCATGGACACCACTGGCCGGACGATCCTGGAAAACAACTCAGGAAGGTCCAACTCAAATCCTTTTAATA
AAGAAGAGCTGACAGCTATTTTGAAATTTGGAGCAGAGGATCTCTTCAAAGAACTGGAAGGGGAGGAATCAGAACCTCAGGAAATGGATA
TAGATGAAATTTTGCGGTTGGCTGAAACGAGAGAGAATGAAGTGTCAACAAGTGCAACAGATGAACTTCTATCACAGTTTAAGGTTGCCA
ACTTTGCAACAATGGAAGATGAAGAAGAGCTAGAAGAGCGTCCTCACAAGGACTGGGATGAGATCATTCCAGAGGAACAAAGGAAAAAAG
TAGAGGAGGAAGAGCGGCAGAAGGAGCTAGAAGAAATTTATATGCTGCCTCGAATTCGGAGTTCCACTAAAAAGGCTCAGACAAATGACA
GTGACTCTGACACTGAGTCTAAGAGGCAGGCCCAGAGATCCTCTGCTTCTGAGAGTGAAACGGAAGACTCTGATGATGACAAGAAGCCAA
AGCGCAGAGGGCGTCCGAGGAGTGTGCGGAAGGACCTCGTGGAGGGATTTACTGATGCAGAGATCCGAAGGTTCATCAAGGCTTATAAGA
AGTTTGGTCTCCCTCTTGAACGGCTGGAGTGCATAGCACGTGATGCTGAGCTGGTAGATAAGTCGGTGGCAGATCTGAAGCGCCTGGGTG
AACTGATCCACAACAGCTGTGTGTCAGCAATGCAGGAATACGAAGAGCAGCTGAAAGAAAATGCCAGCGAGGAGGGAAAAGGAGAGGTCC
AACAATCAAGATATCCGGAGTTCAGGTTAATGTGAAATCCATTATCCAACATGAAGAGGAGTTTGAGATGCTGCATAAATCTATCCCTGT
GGACCCTGAAGAAAAAAAAAAACAGAGACCCGCCCCCAGACAAGAGTTGATGGAGACCCAGGGATTGGACACCATCTCCCAACCCCAGTA
CTCCTGCTCTCCGGTGCCACCTCACCTTCTTTGGCTTCTTCCCTCTTGCCTCCTTCTGTTCTTTCTGCTCTCCCCTCTTTTCCCTCCTCC
TCACTTCCCTCTGGCTAGCCCACCCCTGCACTCTCTCTCATTGCCGCTGCCACTATCACCTGTCTCTCTGCCAGCTGATGTGCCCTGTTG
CCCCCCACCCCATCCCGCACAGAACCATCCCTGCATTCCACAGGGGACTCGGGCAAGGGTGCCGAAGATAGACAAGAGGCACACAGAGAC
AGACCAACTGGCAGCCAGGCAGCCCCAGAGGAGAGAGACATTCAGACAGAGGAAAGTCTCCCTGCCCCTCATTCCTTCCAAGATGAGAAA
AACTTGCCGCCACCCCCCGACACTGATGCCAGGGAGGTGGGAGGAAGAAGTGGGAAATTTCCCTTCCCAGTACCCCCAAGAACGTCTGAG
CCTTCAATGTTGAATTTTTTCTTTATTAAAATTACTTTTATCTTATAAAATCAACTAATCAAAAATGATATAGACGACAGCACTGGCTCT
GTGAAGGTGGCATCTTTCTGGGCAGGCAGGCCATGGGGCATGGAGGAGGGTGCAAAGATATGGGTTGCTGTCTTCTGGCCTCCAGCTGCA
TGGAGGCCGGCCCAGGGTCTAGGGTGTGCACTGGGCAAGGGCAGGGCGGCAGGTGTCAGGCCGGCTTGGACAATGAAACCCTGACCTTGC
TGCATTCCTTTTGCTTCCACCACCACTAGCTTCTTTGGAATCTTGGGGTGGGGGTCATCTTTGGGGATTATGGCTGCCACCCGGGATTTG
AGTGTAGGGAGTGTGGGAGCAGCCTTGGCAGATGGGGCACCCGTGCCCTGCAGGTGTTGACAAGATCCGCCATCTGTAATGTCCTTGGCA

>16305_16305_3_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000557381_OTUD5_chrX_48780479_ENST00000376488_length(amino acids)=1215AA_BP=
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLY
KTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVE
MSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRV
LIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQAR
AHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEP
QEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKA
QTNDSDSDTESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADL

--------------------------------------------------------------
>16305_16305_4_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000557381_OTUD5_chrX_48780479_ENST00000396743_length(transcript)=5380nt_BP=4431nt
CCCTGGGATGGAGGATCTGTCTCTCTCTCTCTCTCTCCTTTTTTTTTTTTTGGTGGAGATGAAGGGGTGGGTCTATGGTACATCACCTGA
GTTGTGGGGTAAATGTAGAGAGTGTCAATCAAAGGCAGAGCTCTCAGAGCTGGGAAGGAGGCTCTAGATGGCGGCTGTGCCTTAGAGAGA
GCGCGCTCTGCTCCCTGCCTTTGCCTCACTTTACGCAACTTTCCCTAACTTTCGGGCAGCCTCAGGGGGCCCCCGTAGCCCCCTGCCTTT
CCTAGGGACTTACTGGGGTCGATTCGAACCTTTTTTTGGGAGAAAAGCAGCTTTTAGGAGCTTTCTTTTCGTGCCTTGTTGGAAAGAAGC
AGCCGTACTGAGAGCCCAGGTCGTTGTTTTTTCCAGCTTAGAAGCCATGGCGCACCTCCATTTTTGTGCGCTCTCCTAATGAGGTTTTTT
TTCTTTCGGACCTGTTTTAGTATTAATTATTGCTTTATTTTTTTGACCAGTTAACATATTTGAGGGTTATTTTATTTATTTTTCGTTTTT
TAACGGAGGATTTTGCCTTTATTTTTAATTATTTGGGATCTGATATTTTTCTACTAGTAGATAGGACTCTTGGTTTGGACATACTACATG
GATCAGTAAATACCTGGGCACAGGACTTCAAAGCAAACACAGATTCCCCCTCCCCCTTAATATTTAAGAATTAAAAGATGATGAGAAATA
AGGACAAAAGCCAAGAGGAGGACAGTTCGCTACACAGCAATGCATCGAGTCACTCAGCCTCTGAAGAAGCTTCGGGTTCAGACTCAGGCA
GTCAGTCGGAAAGTGAGCAGGGAAGTGATCCAGGAAGTGGACATGGCAGCGAGTCGAACAGCAGCTCTGAATCTTCTGAGAGTCAGTCGG
AATCTGAGAGCGAATCAGCAGGTTCCAAATCCCAGCCAGTCCTCCCAGAAGCCAAAGAGAAGCCAGCCTCTAAGAAGGAACGGATAGCTG
ATGTGAAGAAGATGTGGGAAGAATATCCTGATGTTTATGGGGTCAGGCGGTCAAACCGAAGCAGACAAGAACCATCGCGATTTAATATTA
AGGAAGAGGCAAGTAGCGGGTCTGAGAGTGGGAGCCCAAAAAGAAGAGGCCAGAGGCAGCTGAAAAAACAAGAAAAATGGAAACAGGAAC
CCTCAGAAGATGAACAGGAACAAGGCACCAGTGCAGAGAGTGAGCCAGAACAAAAAAAAGTAAAAGCCAGAAGACCTGTCCCCAGAAGAA
CAGTGCCCAAACCTCGTGTTAAAAAGCAGCCGAAGACTCAGCGTGGAAAGAGAAAAAAGCAAGATTCTTCTGATGAGGATGATGATGATG
ACGAAGCTCCCAAAAGGCAGACTCGTCGAAGAGCGGCTAAAAACGTTAGTTACAAAGAAGATGATGACTTTGAGACTGACTCAGATGATC
TCATTGAAATGACTGGAGAAGGAGTTGATGAACAGCAAGATAATAGTGAAACTATTGAAAAGGTCTTAGATTCAAGACTGGGAAAGAAAG
GAGCCACTGGAGCATCTACTACTGTATATGCGATTGAAGCTAATGGCGACCCTAGTGGTGACTTTGACACTGAAAAGGATGAAGGTGAAA
TCCAGTACCTCATCAAGTGGAAGGGTTGGTCTTACATCCACAGCACATGGGAGAGTGAAGAATCCTTACAGCAACAGAAAGTGAAGGGCC
TAAAAAAACTAGAGAACTTCAAGAAAAAAGAGGACGAAATCAAACAATGGTTAGGGAAAGTTTCTCCTGAAGATGTAGAATATTTCAATT
GCCAACAGGAGCTGGCTTCAGAGTTGAATAAACAGTATCAGATAGTAGAAAGAGTAATAGCTGTGAAGACAAGTAAATCTACATTGGGTC
AAACAGATTTTCCAGCTCATAGTCGGAAGCCGGCACCCTCAAATGAGCCCGAATATCTATGTAAATGGATGGGACTCCCCTATTCAGAGT
GTAGCTGGGAAGATGAAGCCCTCATTGGAAAGAAATTCCAGAATTGCATTGACAGCTTCCACAGTAGGAACAACTCAAAAACCATCCCAA
CAAGAGAATGCAAGGCCCTGAAGCAGAGACCACGATTTGTAGCTTTAAAGAAACAACCTGCATATTTAGGAGGGGAGAATCTGGAACTTC
GAGATTATCAGCTAGAAGGTCTAAACTGGCTAGCTCATTCCTGGTGCAAAAATAATAGTGTAATCCTTGCTGATGAAATGGGCCTAGGAA
AGACCATCCAGACCATATCATTCCTCTCCTACCTGTTCCACCAACACCAGCTGTATGGCCCCTTTCTTATAGTCGTCCCTTTATCCACCC
TCACCTCATGGCAGAGAGAGTTTGAAATCTGGGCACCAGAGATTAACGTAGTGGTTTACATAGGTGACCTGATGAGCAGAAATACGATAC
GGGAATATGAATGGATTCATTCCCAAACCAAAAGATTGAAGTTCAACGCACTTATAACAACATATGAGATCCTCTTGAAAGATAAGACTG
TGCTGGGCAGTATTAACTGGGCCTTTCTGGGAGTGGATGAAGCCCATCGGTTGAAGAATGATGACTCTTTATTGTATAAAACTCTGATTG
ATTTCAAGTCCAACCATAGGCTCCTGATTACGGGGACCCCTCTTCAGAATTCCCTCAAAGAGCTCTGGTCCTTGCTGCACTTTATTATGC
CGGAGAAGTTTGAATTTTGGGAAGATTTTGAAGAAGACCATGGGAAGGGGAGAGAAAATGGCTACCAGAGTCTTCATAAGGTGCTAGAGC
CTTTCCTTCTCCGGAGAGTCAAAAAAGATGTGGAGAAATCCCTTCCTGCTAAAGTGGAACAGATTCTCAGGGTGGAGATGTCAGCCCTTC
AGAAACAGTATTACAAGTGGATTCTGACCAGGAATTACAAGGCTCTTGCCAAAGGAACAAGAGGCAGCACATCTGGTTTTCTTAATATTG
TGATGGAACTGAAAAAATGTTGCAACCACTGCTATCTGATTAAACCCCCTGAAGAAAATGAAAGGGAAAATGGACAGGAGATTCTTCTGT
CCCTCATAAGGAGCAGTGGGAAGTTGATTTTATTAGACAAACTGTTGACAAGACTTCGAGAAAGGGGGAATCGAGTGCTTATCTTCTCTC
AGATGGTGAGAATGTTGGATATCCTGGCTGAATACCTAACTATTAAACACTATCCTTTCCAGCGTCTGGATGGTTCCATCAAGGGAGAAA
TCCGAAAACAGGCACTGGACCACTTCAATGCAGATGGGTCTGAGGACTTCTGTTTCCTGCTCTCGACAAGGGCTGGTGGCCTGGGAATCA
ATTTGGCTTCAGCGGACACAGTCGTCATCTTTGACTCTGACTGGAACCCCCAGAATGACTTGCAGGCACAAGCCCGAGCGCATAGAATTG
GTCAAAAGAAGCAGGTAAATATTTACCGCTTAGTTACAAAGGGGACTGTGGAGGAGGAGATCATAGAACGGGCCAAAAAGAAGATGGTAT
TAGATCATCTGGTGATTCAGCGCATGGACACCACTGGCCGGACGATCCTGGAAAACAACTCAGGAAGGTCCAACTCAAATCCTTTTAATA
AAGAAGAGCTGACAGCTATTTTGAAATTTGGAGCAGAGGATCTCTTCAAAGAACTGGAAGGGGAGGAATCAGAACCTCAGGAAATGGATA
TAGATGAAATTTTGCGGTTGGCTGAAACGAGAGAGAATGAAGTGTCAACAAGTGCAACAGATGAACTTCTATCACAGTTTAAGGTTGCCA
ACTTTGCAACAATGGAAGATGAAGAAGAGCTAGAAGAGCGTCCTCACAAGGACTGGGATGAGATCATTCCAGAGGAACAAAGGAAAAAAG
TAGAGGAGGAAGAGCGGCAGAAGGAGCTAGAAGAAATTTATATGCTGCCTCGAATTCGGAGTTCCACTAAAAAGGCTCAGACAAATGACA
GTGACTCTGACACTGAGTCTAAGAGGCAGGCCCAGAGATCCTCTGCTTCTGAGAGTGAAACGGAAGACTCTGATGATGACAAGAAGCCAA
AGCGCAGAGGGCGTCCGAGGAGTGTGCGGAAGGACCTCGTGGAGGGATTTACTGATGCAGAGATCCGAAGGTTCATCAAGGCTTATAAGA
AGTTTGGTCTCCCTCTTGAACGGCTGGAGTGCATAGCACGTGATGCTGAGCTGGTAGATAAGTCGGTGGCAGATCTGAAGCGCCTGGGTG
AACTGATCCACAACAGCTGTGTGTCAGCAATGCAGGAATACGAAGAGCAGCTGAAAGAAAATGCCAGCGAGGAGGGAAAAGGAGAGGTCC
AACAATCAAGATATCCGGAGTTCAGGTTAATGTGAAATCCATTATCCAACATGAAGAGGAGTTTGAGATGCTGCATAAATCTATCCCTGT
GGACCCTGAAGAAAAAAAAAAGGGACTCGGGCAAGGGTGCCGAAGATAGACAAGAGGCACACAGAGACAGACCAACTGGCAGCCAGGCAG
CCCCAGAGGAGAGAGACATTCAGACAGAGGAAAGTCTCCCTGCCCCTCATTCCTTCCAAGATGAGAAAAACTTGCCGCCACCCCCCGACA
CTGATGCCAGGGAGGTGGGAGGAAGAAGTGGGAAATTTCCCTTCCCAGTACCCCCAAGAACGTCTGAGCCTTCAATGTTGAATTTTTTCT
TTATTAAAATTACTTTTATCTTATAAAATCAACTAATCAAAAATGATATAGACGACAGCACTGGCTCTGTGAAGGTGGCATCTTTCTGGG
CAGGCAGGCCATGGGGCATGGAGGAGGGTGCAAAGATATGGGTTGCTGTCTTCTGGCCTCCAGCTGCATGGAGGCCGGCCCAGGGTCTAG
GGTGTGCACTGGGCAAGGGCAGGGCGGCAGGTGTCAGGCCGGCTTGGACAATGAAACCCTGACCTTGCTGCATTCCTTTTGCTTCCACCA
CCACTAGCTTCTTTGGAATCTTGGGGTGGGGGTCATCTTTGGGGATTATGGCTGCCACCCGGGATTTGAGTGTAGGGAGTGTGGGAGCAG
CCTTGGCAGATGGGGCACCCGTGCCCTGCAGGTGTTGACAAGATCCGCCATCTGTAATGTCCTTGGCACAATAAAACCAAATGTCAGTTT
CCCTGAGCGACTCTGTTCTGTGTGGGGCAGGGGTTGGGCGGGCCTCTGGGCAGAGGATGCAATGGCACGGACCTTGGCTTGACCTCAGAG
GTGTGAATGCTCTCCAGCAGGGTCTGTCTGGGGGCCTGGAGTTTGTATTTGATTTGCTGCTTATTAAACCTCCTTCTGGACCTATTGCCA

>16305_16305_4_CHD2-OTUD5_CHD2_chr15_93540196_ENST00000557381_OTUD5_chrX_48780479_ENST00000396743_length(amino acids)=1215AA_BP=
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLY
KTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGKGRENGYQSLHKVLEPFLLRRVKKDVEKSLPAKVEQILRVE
MSALQKQYYKWILTRNYKALAKGTRGSTSGFLNIVMELKKCCNHCYLIKPPEENERENGQEILLSLIRSSGKLILLDKLLTRLRERGNRV
LIFSQMVRMLDILAEYLTIKHYPFQRLDGSIKGEIRKQALDHFNADGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQAR
AHRIGQKKQVNIYRLVTKGTVEEEIIERAKKKMVLDHLVIQRMDTTGRTILENNSGRSNSNPFNKEELTAILKFGAEDLFKELEGEESEP
QEMDIDEILRLAETRENEVSTSATDELLSQFKVANFATMEDEEELEERPHKDWDEIIPEEQRKKVEEEERQKELEEIYMLPRIRSSTKKA
QTNDSDSDTESKRQAQRSSASESETEDSDDDKKPKRRGRPRSVRKDLVEGFTDAEIRRFIKAYKKFGLPLERLECIARDAELVDKSVADL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHD2-OTUD5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHD2-OTUD5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHD2-OTUD5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource