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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHD7-TOX (FusionGDB2 ID:16383)

Fusion Gene Summary for CHD7-TOX

check button Fusion gene summary
Fusion gene informationFusion gene name: CHD7-TOX
Fusion gene ID: 16383
HgeneTgene
Gene symbol

CHD7

TOX

Gene ID

55636

9760

Gene namechromodomain helicase DNA binding protein 7thymocyte selection associated high mobility group box
SynonymsCRG|HH5|IS3|KAL5TOX1
Cytomap

8q12.2

8q12.1

Type of geneprotein-codingprotein-coding
Descriptionchromodomain-helicase-DNA-binding protein 7ATP-dependent helicase CHD7CHARGE associationchromodomain helicase DNA binding protein 7 isoform CRA_ethymocyte selection-associated high mobility group box protein TOXthymus high mobility group box protein TOX
Modification date2020032820200313
UniProtAcc

Q9P2D1

TOX4

Ensembl transtripts involved in fusion geneENST00000423902, ENST00000524602, 
ENST00000525508, ENST00000529472, 
ENST00000361421, 
Fusion gene scores* DoF score12 X 8 X 8=7688 X 5 X 6=240
# samples 178
** MAII scorelog2(17/768*10)=-2.17557156458345
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHD7 [Title/Abstract] AND TOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHD7(61655656)-TOX(59872567), # samples:9
TOX(60031445)-CHD7(61693559), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHD7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-4T-AA8H-01ACHD7chr8

61655656

-TOXchr8

59872567

-
ChimerDB4COADTCGA-4T-AA8H-01ACHD7chr8

61655656

+TOXchr8

59872567

-
ChimerDB4COADTCGA-CM-6172-01ACHD7chr8

61655656

-TOXchr8

59872567

-
ChimerDB4COADTCGA-CM-6172-01ACHD7chr8

61655656

+TOXchr8

59872567

-
ChimerDB4COADTCGA-CM-6172CHD7chr8

61655656

+TOXchr8

59872567

-
ChimerDB4GBMTCGA-06-5414-01ACHD7chr8

61655656

-TOXchr8

59872567

-
ChimerDB4GBMTCGA-06-5414-01ACHD7chr8

61655656

+TOXchr8

59872567

-


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Fusion Gene ORF analysis for CHD7-TOX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000423902ENST00000361421CHD7chr8

61655656

+TOXchr8

59872567

-
In-frameENST00000524602ENST00000361421CHD7chr8

61655656

+TOXchr8

59872567

-
In-frameENST00000525508ENST00000361421CHD7chr8

61655656

+TOXchr8

59872567

-
intron-3CDSENST00000529472ENST00000361421CHD7chr8

61655656

+TOXchr8

59872567

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423902CHD7chr861655656+ENST00000361421TOXchr859872567-5952214444636221058
ENST00000524602CHD7chr861655656+ENST00000361421TOXchr859872567-554117333532111058
ENST00000525508CHD7chr861655656+ENST00000361421TOXchr859872567-54731665031431047

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423902ENST00000361421CHD7chr861655656+TOXchr859872567-0.0010238820.9989761
ENST00000524602ENST00000361421CHD7chr861655656+TOXchr859872567-0.0005845770.9994154
ENST00000525508ENST00000361421CHD7chr861655656+TOXchr859872567-0.0005293230.99947065

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Fusion Genomic Features for CHD7-TOX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHD7-TOX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:61655656/chr8:59872567)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHD7

Q9P2D1

TOX

TOX4

FUNCTION: Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production. {ECO:0000269|PubMed:22646239}.621

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238151_2225552998.0Compositional biasNote=Gln-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15151_222555949.0Compositional biasNote=Gln-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112151_2225551139.0Compositional biasNote=Gln-rich
TgeneTOXchr8:61655656chr8:59872567ENST0000036142109417_42034527.0Compositional biasNote=Poly-Pro
TgeneTOXchr8:61655656chr8:59872567ENST0000036142109261_32934527.0DNA bindingHMG box
TgeneTOXchr8:61655656chr8:59872567ENST0000036142109237_25634527.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2382401_24315552998.0Coiled coilOntology_term=ECO:0000255
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+152401_2431555949.0Coiled coilOntology_term=ECO:0000255
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1122401_24315551139.0Coiled coilOntology_term=ECO:0000255
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2381939_19455552998.0Compositional biasNote=Poly-Arg
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2382165_22585552998.0Compositional biasNote=Glu-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2382398_24055552998.0Compositional biasNote=Poly-Arg
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2382726_27365552998.0Compositional biasNote=Poly-Ala
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238383_5685552998.0Compositional biasNote=Pro-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238597_7185552998.0Compositional biasNote=Lys-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+151939_1945555949.0Compositional biasNote=Poly-Arg
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+152165_2258555949.0Compositional biasNote=Glu-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+152398_2405555949.0Compositional biasNote=Poly-Arg
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+152726_2736555949.0Compositional biasNote=Poly-Ala
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15383_568555949.0Compositional biasNote=Pro-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15597_718555949.0Compositional biasNote=Lys-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1121939_19455551139.0Compositional biasNote=Poly-Arg
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1122165_22585551139.0Compositional biasNote=Glu-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1122398_24055551139.0Compositional biasNote=Poly-Arg
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1122726_27365551139.0Compositional biasNote=Poly-Ala
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112383_5685551139.0Compositional biasNote=Pro-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112597_7185551139.0Compositional biasNote=Lys-rich
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2381294_14645552998.0DomainHelicase C-terminal
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238800_8675552998.0DomainChromo 1
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238882_9475552998.0DomainChromo 2
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238980_11545552998.0DomainHelicase ATP-binding
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+151294_1464555949.0DomainHelicase C-terminal
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15800_867555949.0DomainChromo 1
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15882_947555949.0DomainChromo 2
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15980_1154555949.0DomainHelicase ATP-binding
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1121294_14645551139.0DomainHelicase C-terminal
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112800_8675551139.0DomainChromo 1
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112882_9475551139.0DomainChromo 2
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112980_11545551139.0DomainHelicase ATP-binding
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+2381105_11085552998.0MotifNote=DEAH box
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+151105_1108555949.0MotifNote=DEAH box
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+1121105_11085551139.0MotifNote=DEAH box
HgeneCHD7chr8:61655656chr8:59872567ENST00000423902+238993_10005552998.0Nucleotide bindingATP
HgeneCHD7chr8:61655656chr8:59872567ENST00000524602+15993_1000555949.0Nucleotide bindingATP
HgeneCHD7chr8:61655656chr8:59872567ENST00000525508+112993_10005551139.0Nucleotide bindingATP


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Fusion Gene Sequence for CHD7-TOX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16383_16383_1_CHD7-TOX_CHD7_chr8_61655656_ENST00000423902_TOX_chr8_59872567_ENST00000361421_length(transcript)=5952nt_BP=2144nt
CGGCGGCGGCGGCAGCGGCGGCGGCGGCGGCGGCGCGGGGGTTGAGTCGTGGTGGTGCGGACGCGCTCGTGCTCGGGAACTATCGGATTA
AACTTGAATCGAGTGAAATTACACAAAGGAGCGCCGCGGAGGAGGCGGCCCGGGGACCCGGACACCCTGAAACTCACCAGAGACCCGTTC
GCCCCCGGCCAACTCCGTGCCCGTGGATTCAGCCCCCTGGCCGCAGCTGCCGAGCCAACTCCGGAGCCCGCTCTGCGTTTTGTTTTCCCC
TCGGCACTAGGCAGCGGAGGAGCCCGACCGACCCGGACCTATATCCAGACTTTGCCTGACACTGCAGGGTCCAAGAGAATTAAAGAAATA
TGGAATGACATGAAGAAGATTAGTTAAGGATTATAGGCTTTGAGGGCAAACACCTCAGTGAAGTGAAGCACAGGCAAGCTCCTGAGCTGT
GGTTTGGAGGAGCCGTGTGTTGGAAGAAGATGGCAGATCCAGGAATGATGAGTCTTTTTGGCGAGGATGGGAATATTTTCAGTGAAGGTC
TTGAAGGCCTCGGAGAATGTGGTTACCCGGAAAATCCAGTAAATCCTATGGGTCAGCAAATGCCAATAGACCAAGGCTTTGCCTCTTTAC
AGCCATCCCTTCATCATCCTTCAACTAATCAAAATCAAACAAAGCTGACACATTTTGATCACTATAATCAGTATGAACAACAAAAGATGC
ATCTGATGGATCAGCCGAACAGAATGATGAGCAACACCCCTGGGAACGGACTCGCGTCTCCGCACTCGCAGTATCACACCCCTCCCGTTC
CTCAGGTGCCCCATGGTGGCAGTGGTGGCGGTCAGATGGGTGTCTACCCTGGCATGCAGAATGAGAGGCATGGGCAATCCTTTGTGGACA
GCAGCTCCATGTGGGGCCCCAGGGCTGTTCAGGTACCAGACCAGATACGAGCCCCCTACCAGCAGCAGCAGCCACAGCCGCAGCCACCGC
AGCCGGCTCCGTCGGGGCCCCCTGCACAGGGCCACCCTCAGCACATGCAGCAGATGGGCAGCTATATGGCACGTGGGGATTTTTCCATGC
AGCAGCATGGTCAGCCACAGCAGAGGATGAGCCAGTTTTCCCAAGGCCAAGAGGGCCTCAATCAGGGAAATCCTTTTATTGCCACCTCAG
GACCTGGCCACTTGTCCCACGTGCCCCAGCAGAGTCCCAGCATGGCACCTTCCTTGCGTCACTCGGTGCAGCAGTTCCATCACCACCCCT
CTACTGCTCTCCATGGAGAATCCGTTGCCCACAGTCCCAGATTCTCCCCGAATCCTCCCCAACAAGGGGCTGTTAGGCCGCAAACCCTTA
ACTTTAGTTCTCGGAGCCAGACAGTCCCCTCTCCTACTATAAACAACTCAGGGCAGTATTCTCGATATCCTTACAGTAACCTAAATCAGG
GATTAGTTAACAATACAGGGATGAATCAAAATTTAGGCCTTACAAATAATACTCCAATGAATCAGTCCGTACCAAGATACCCCAATGCTG
TAGGATTCCCATCAAACAGTGGTCAAGGACTAATGCACCAGCAGCCCATCCACCCCAGTGGCTCACTTAACCAAATGAACACACAAACTA
TGCATCCTTCACAGCCTCAGGGAACTTATGCCTCTCCACCTCCCATGTCACCCATGAAAGCAATGAGTAATCCAGCAGGCACTCCTCCTC
CACAAGTCAGGCCGGGAAGTGCTGGGATACCAATGGAAGTTGGCAGTTATCCAAATATGCCCCATCCTCAGCCATCTCACCAGCCCCCTG
GTGCCATGGGAATCGGACAGAGGAATATGGGCCCCAGAAACATGCAGCAGTCTCGTCCATTTATAGGCATGTCCTCGGCACCAAGGGAAT
TGACTGGGCACATGAGGCCAAATGGTTGTCCTGGTGTTGGCCTTGGAGACCCACAAGCAATCCAGGAACGACTGATACCTGGCCAACAAC
ATCCTGGTCAACAGCCATCTTTTCAGCAGTTGCCAACCTGTCCTCCACTGCAGCCTCACCCGGGCTTGCACCACCAGTCTTCACCTCCAC
ACCCTCATCACCAGCCTTGGGCACAGCTCCACCCATCACCCCAGAACACCCCGCAGAAAGTGCCTGTGCATCAGTTTGACGGTGAGAACA
TGTATATGAGCATGACAGAGCCGAGCCAGGACTATGTGCCAGCCAGCCAGTCCTACCCTGGTCCAAGCCTGGAAAGTGAAGACTTCAACA
TTCCACCAATTACTCCTCCTTCCCTCCCAGACCACTCGCTGGTGCACCTGAATGAAGTTGAGTCTGGTTACCATTCTCTGTGTCACCCCA
TGAACCATAATGGCCTGCTACCATTTCATCCACAAAACATGGACCTCCCTGAAATCACAGTCTCCAATATGCTGGGCCAGGATGGAACAC
TGCTTTCTAATTCCATTTCTGTGATGCCAGATATACGAAACCCAGAAGGAACTCAGTACAGTTCCCATCCTCAGATGGCAGCCATGAGAC
CAAGGGGCCAGCCTGCAGACATCAGGCAGCAGCCAGGAATGATGCCACATGGCCAGCTGACTACCATTAACCAGTCACAGCTAAGTGCTC
AACTTGGTTTGAATATGGGAGGAAGCAATGTTCCCCACAACTCACCATCTCCACCTGGAAGCAAGTCTGCAACTCCTTCACCATCCAGTT
CAGTGCATGAAGATGAAGGCGATGATACCTCTAAGATCAATGGTGGAGAGAAGCGGCCTGCCTCTGATATGGGGAAAAAACCAAAAACTC
CCAAAAAGAAGAAGAAGAAGGATCCCAATGAGCCCCAGAAGCCTGTGTCTGCCTATGCGTTATTCTTTCGTGATACTCAGGCCGCCATCA
AGGGCCAAAATCCAAACGCTACCTTTGGCGAAGTCTCTAAAATTGTGGCTTCAATGTGGGACGGTTTAGGAGAAGAGCAAAAACAGGTCT
ATAAAAAGAAAACCGAGGCTGCGAAGAAGGAGTACCTGAAGCAACTCGCAGCATACAGAGCCAGCCTTGTATCCAAGAGCTACAGTGAAC
CTGTTGACGTGAAGACATCTCAACCTCCTCAGCTGATCAATTCGAAGCCGTCGGTGTTCCATGGGCCCAGCCAGGCCCACTCGGCCCTGT
ACCTAAGTTCCCACTATCACCAACAACCGGGAATGAATCCTCACCTAACTGCCATGCATCCTAGTCTCCCCAGGAACATAGCCCCCAAGC
CGAATAACCAAATGCCAGTGACTGTCTCTATAGCAAACATGGCTGTGTCCCCTCCTCCTCCCCTCCAGATCAGCCCGCCTCTTCACCAGC
ATCTCAACATGCAGCAGCACCAGCCGCTCACCATGCAGCAGCCCCTTGGGAACCAGCTCCCCATGCAGGTCCAGTCTGCCTTACACTCAC
CCACCATGCAGCAAGGATTTACTCTTCAACCCGACTATCAGACTATTATCAATCCTACATCTACAGCTGCACAAGTTGTCACCCAGGCAA
TGGAGTATGTGCGTTCGGGGTGCAGAAATCCTCCCCCACAACCGGTGGACTGGAATAACGACTACTGCAGTAGTGGGGGCATGCAGAGGG
ACAAAGCACTGTACCTTACTTGAGAATCTGAACACCTCTTCTTTCCACTGAGGAATTCAGGGAAGTGTTTTCACCATGGATTGCTTTGTA
CAGTCAAGGCAGTTCTCCATTTTATTAGAAAATACAAGTTGCTAAGCACTTAGGACCATTTGAGCTTGTGGGTCACCCACTCTGGAAGAA
ATAGTCATGCTTCTTTATTATTTTTTTAATCCTTTATGGACATTGTTTTTCTTCTTCCCTGAAGGAAATTTGGACCATTCAGATTTTATG
TTGGTTTTTTGCTGTGAAGTGCTGCGCTCTAGTAACTGCCTTAGCAACTGTAGATGTCTCGGATAAAAGTCCTGGATTTTCCATTGGTTT
TCATAATGGGTGTTTATATGAAACTACTAAAGACTTTTTAAATGGCTTGATGTAGCAGTCATAGCAAGTTTGTAAATAGCATCTATGTTA
CACTCTCCTAGAGTATAAAATGTGAATGTTTTTGTAGCTAAATTGTAATTGAAACTGGCTCATTCCAGTTTATTGATTTCACAATAGGGG
TTAAATTGGCAAACATTCATATTTTTACTTCATTTTTAAAACAACTGACTGATAGTTCTATATTTTCAAAATATTTGAAAATAAAAAGTA
TTCCCAAGTGATTTTAATTTAAAAACAAATTGGCTTTGTCTCATTGATCAGACAAAAAGAAACTAGTATTAAGGGAAGCGCAAACACATT
TATTTTGTACTGCAGAAAAATTGCTTTTTTGTATCACTTTTTGTGTAATGGTTAGTAAATGTCATTTAAGTCCTTTTATGTATAAAACTG
CCAAATGCTTACCTGGTATTTTATTAGATGCAGAAACAGATTGGAAACAGCTAAATTACAACTTTTACATATGGCTCTGTCTTATTGTTT
CTTCATACTGTGTCTGTATTTAATCTTTTTTTATGGAACCTGTTGCGCCTATTTATGAAATAATAAATATAGGTGTTTGTAAGTAAATTT
GTTAGTATTTGAAAGAGGTTTCTTTGATGTTTTAACTTTTGCTGGCAAAAAAAAATTCACGCTTGGTGTGAATACTTTATTATTTAGTTT
TTACAGTAACATGAATAAAGCCAAACCTGCTTTTCATTTAGCAGCAAATTAAAGTAACCAGTCCTTATTTCTGCATTTCTTTGGTTGATG
CAAACAAAAAACTATTATATTTAAGAACTTTATTTCTTCATACGACATAACAGAATTGCCCTCCAAGTCACACAAGCTCCAAGACTAAAC
AAACAGACAGGTCCTCTGTCTTAAAAAGGTTACTTCTTGGTTCTCAGCTGGTTCTAGTCAATTCTGAACCACCACCCCCCGCCCCCCGCA
AAAAAGTAAAAGTCAAACCAAACTTCCTCAAGCTGCATGCTTTTCACAAAATCCAGAAAGCATTTAAGAATTGAACTAGGGGCTGGAAGA
AGTGAAAGGGAAGCATCTAAAAATGAAAGGTGAGTAACCAGATAGCAAAAGAAAAGGGAAAGCCATCCAAATTTGAAAGCTGTTGATAGA
AATTGAGATTCTTGCTGTCTTTTGTGCCTCTACAAGCTACTACTCATTCCAGAATTCCTGGGTCTTCCAAGAGGATTCTTAAGGTACCAG
AGATTTGCTAGGGAACCAAAAGTGCTTGAGAATCTGCCTGAGGGCTTGCATAGCTTTCACATTAAAAAAAGAAAAAGCTAGCAGATTTAC
TCCTTTTTAGGGGATCATATCAAGAAAGTTAGTCTGGTTGGAAACCAAGAGAATGGCTGATGTCTCTTTCTTGGAATATGTGAAATAAAT
TTAGCAGTTTAACTAAATACAAATATATGCATTGTGTAATCCACTCAGAATTAAACAGACAAAAGGTATGCTTGCTTTGGAATGATTTTA
GGCATTGTACAACCTTGAATCACTTGAGCATGTAATAACTAATAAATAATGCAGATCCATGTGATTATTAAAATGACTGTAGCTGAGAGC
TCTAATTTTCCTGTCTTGAAACTGTATAAGAACTCATGTGATTAAGTTCACAGTTTATTGTTTGTCTGTTTAGTATTTTAGAAATATACC
AGCACTACTAATTAACTAATGTCTTTTATTTATTATATTATGATAAAGTAAAAATTTCACTTGCATTAAGTCTAAACTGAGAAGGTAATT
ACTGGGAGGAGAATGAGCAGCTTTGACTTTGACAGGCGGTTTGTGCAGGAAAGCACAGTGCCGTGTTGTTTACAGCTTTTCTAGAGCAGC
TGTGCGACCAGGGTAGAGAGTGTTGAAATTCAATACCAAATACAGTAAAAACAAATGTAAATAAAAGAAAACACATCATCAATAAAACTG

>16383_16383_1_CHD7-TOX_CHD7_chr8_61655656_ENST00000423902_TOX_chr8_59872567_ENST00000361421_length(amino acids)=1058AA_BP=565
MWFGGAVCWKKMADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTNQNQTKLTHFDHYNQYEQQK
MHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGGGQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQP
PQPAPSGPPAQGHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQQSPSMAPSLRHSVQQFHHH
PSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPN
AVGFPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGIPMEVGSYPNMPHPQPSHQP
PGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGCPGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSP
PHPHHQPWAQLHPSPQNTPQKVPVHQFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCH
PMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLS
AQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAA
IKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSA
LYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALH

--------------------------------------------------------------
>16383_16383_2_CHD7-TOX_CHD7_chr8_61655656_ENST00000524602_TOX_chr8_59872567_ENST00000361421_length(transcript)=5541nt_BP=1733nt
ACCTCAGTGAAGTGAAGCACAGGCAAGCTCCTGAGCTGTGGTTTGGAGGAGCCGTGTGTTGGAAGAAGATGGCAGATCCAGGAATGATGA
GTCTTTTTGGCGAGGATGGGAATATTTTCAGTGAAGGTCTTGAAGGCCTCGGAGAATGTGGTTACCCGGAAAATCCAGTAAATCCTATGG
GTCAGCAAATGCCAATAGACCAAGGCTTTGCCTCTTTACAGCCATCCCTTCATCATCCTTCAACTAATCAAAATCAAACAAAGCTGACAC
ATTTTGATCACTATAATCAGTATGAACAACAAAAGATGCATCTGATGGATCAGCCGAACAGAATGATGAGCAACACCCCTGGGAACGGAC
TCGCGTCTCCGCACTCGCAGTATCACACCCCTCCCGTTCCTCAGGTGCCCCATGGTGGCAGTGGTGGCGGTCAGATGGGTGTCTACCCTG
GCATGCAGAATGAGAGGCATGGGCAATCCTTTGTGGACAGCAGCTCCATGTGGGGCCCCAGGGCTGTTCAGGTACCAGACCAGATACGAG
CCCCCTACCAGCAGCAGCAGCCACAGCCGCAGCCACCGCAGCCGGCTCCGTCGGGGCCCCCTGCACAGGGCCACCCTCAGCACATGCAGC
AGATGGGCAGCTATATGGCACGTGGGGATTTTTCCATGCAGCAGCATGGTCAGCCACAGCAGAGGATGAGCCAGTTTTCCCAAGGCCAAG
AGGGCCTCAATCAGGGAAATCCTTTTATTGCCACCTCAGGACCTGGCCACTTGTCCCACGTGCCCCAGCAGAGTCCCAGCATGGCACCTT
CCTTGCGTCACTCGGTGCAGCAGTTCCATCACCACCCCTCTACTGCTCTCCATGGAGAATCCGTTGCCCACAGTCCCAGATTCTCCCCGA
ATCCTCCCCAACAAGGGGCTGTTAGGCCGCAAACCCTTAACTTTAGTTCTCGGAGCCAGACAGTCCCCTCTCCTACTATAAACAACTCAG
GGCAGTATTCTCGATATCCTTACAGTAACCTAAATCAGGGATTAGTTAACAATACAGGGATGAATCAAAATTTAGGCCTTACAAATAATA
CTCCAATGAATCAGTCCGTACCAAGATACCCCAATGCTGTAGGATTCCCATCAAACAGTGGTCAAGGACTAATGCACCAGCAGCCCATCC
ACCCCAGTGGCTCACTTAACCAAATGAACACACAAACTATGCATCCTTCACAGCCTCAGGGAACTTATGCCTCTCCACCTCCCATGTCAC
CCATGAAAGCAATGAGTAATCCAGCAGGCACTCCTCCTCCACAAGTCAGGCCGGGAAGTGCTGGGATACCAATGGAAGTTGGCAGTTATC
CAAATATGCCCCATCCTCAGCCATCTCACCAGCCCCCTGGTGCCATGGGAATCGGACAGAGGAATATGGGCCCCAGAAACATGCAGCAGT
CTCGTCCATTTATAGGCATGTCCTCGGCACCAAGGGAATTGACTGGGCACATGAGGCCAAATGGTTGTCCTGGTGTTGGCCTTGGAGACC
CACAAGCAATCCAGGAACGACTGATACCTGGCCAACAACATCCTGGTCAACAGCCATCTTTTCAGCAGTTGCCAACCTGTCCTCCACTGC
AGCCTCACCCGGGCTTGCACCACCAGTCTTCACCTCCACACCCTCATCACCAGCCTTGGGCACAGCTCCACCCATCACCCCAGAACACCC
CGCAGAAAGTGCCTGTGCATCAGTTTGACGGTGAGAACATGTATATGAGCATGACAGAGCCGAGCCAGGACTATGTGCCAGCCAGCCAGT
CCTACCCTGGTCCAAGCCTGGAAAGTGAAGACTTCAACATTCCACCAATTACTCCTCCTTCCCTCCCAGACCACTCGCTGGTGCACCTGA
ATGAAGTTGAGTCTGGTTACCATTCTCTGTGTCACCCCATGAACCATAATGGCCTGCTACCATTTCATCCACAAAACATGGACCTCCCTG
AAATCACAGTCTCCAATATGCTGGGCCAGGATGGAACACTGCTTTCTAATTCCATTTCTGTGATGCCAGATATACGAAACCCAGAAGGAA
CTCAGTACAGTTCCCATCCTCAGATGGCAGCCATGAGACCAAGGGGCCAGCCTGCAGACATCAGGCAGCAGCCAGGAATGATGCCACATG
GCCAGCTGACTACCATTAACCAGTCACAGCTAAGTGCTCAACTTGGTTTGAATATGGGAGGAAGCAATGTTCCCCACAACTCACCATCTC
CACCTGGAAGCAAGTCTGCAACTCCTTCACCATCCAGTTCAGTGCATGAAGATGAAGGCGATGATACCTCTAAGATCAATGGTGGAGAGA
AGCGGCCTGCCTCTGATATGGGGAAAAAACCAAAAACTCCCAAAAAGAAGAAGAAGAAGGATCCCAATGAGCCCCAGAAGCCTGTGTCTG
CCTATGCGTTATTCTTTCGTGATACTCAGGCCGCCATCAAGGGCCAAAATCCAAACGCTACCTTTGGCGAAGTCTCTAAAATTGTGGCTT
CAATGTGGGACGGTTTAGGAGAAGAGCAAAAACAGGTCTATAAAAAGAAAACCGAGGCTGCGAAGAAGGAGTACCTGAAGCAACTCGCAG
CATACAGAGCCAGCCTTGTATCCAAGAGCTACAGTGAACCTGTTGACGTGAAGACATCTCAACCTCCTCAGCTGATCAATTCGAAGCCGT
CGGTGTTCCATGGGCCCAGCCAGGCCCACTCGGCCCTGTACCTAAGTTCCCACTATCACCAACAACCGGGAATGAATCCTCACCTAACTG
CCATGCATCCTAGTCTCCCCAGGAACATAGCCCCCAAGCCGAATAACCAAATGCCAGTGACTGTCTCTATAGCAAACATGGCTGTGTCCC
CTCCTCCTCCCCTCCAGATCAGCCCGCCTCTTCACCAGCATCTCAACATGCAGCAGCACCAGCCGCTCACCATGCAGCAGCCCCTTGGGA
ACCAGCTCCCCATGCAGGTCCAGTCTGCCTTACACTCACCCACCATGCAGCAAGGATTTACTCTTCAACCCGACTATCAGACTATTATCA
ATCCTACATCTACAGCTGCACAAGTTGTCACCCAGGCAATGGAGTATGTGCGTTCGGGGTGCAGAAATCCTCCCCCACAACCGGTGGACT
GGAATAACGACTACTGCAGTAGTGGGGGCATGCAGAGGGACAAAGCACTGTACCTTACTTGAGAATCTGAACACCTCTTCTTTCCACTGA
GGAATTCAGGGAAGTGTTTTCACCATGGATTGCTTTGTACAGTCAAGGCAGTTCTCCATTTTATTAGAAAATACAAGTTGCTAAGCACTT
AGGACCATTTGAGCTTGTGGGTCACCCACTCTGGAAGAAATAGTCATGCTTCTTTATTATTTTTTTAATCCTTTATGGACATTGTTTTTC
TTCTTCCCTGAAGGAAATTTGGACCATTCAGATTTTATGTTGGTTTTTTGCTGTGAAGTGCTGCGCTCTAGTAACTGCCTTAGCAACTGT
AGATGTCTCGGATAAAAGTCCTGGATTTTCCATTGGTTTTCATAATGGGTGTTTATATGAAACTACTAAAGACTTTTTAAATGGCTTGAT
GTAGCAGTCATAGCAAGTTTGTAAATAGCATCTATGTTACACTCTCCTAGAGTATAAAATGTGAATGTTTTTGTAGCTAAATTGTAATTG
AAACTGGCTCATTCCAGTTTATTGATTTCACAATAGGGGTTAAATTGGCAAACATTCATATTTTTACTTCATTTTTAAAACAACTGACTG
ATAGTTCTATATTTTCAAAATATTTGAAAATAAAAAGTATTCCCAAGTGATTTTAATTTAAAAACAAATTGGCTTTGTCTCATTGATCAG
ACAAAAAGAAACTAGTATTAAGGGAAGCGCAAACACATTTATTTTGTACTGCAGAAAAATTGCTTTTTTGTATCACTTTTTGTGTAATGG
TTAGTAAATGTCATTTAAGTCCTTTTATGTATAAAACTGCCAAATGCTTACCTGGTATTTTATTAGATGCAGAAACAGATTGGAAACAGC
TAAATTACAACTTTTACATATGGCTCTGTCTTATTGTTTCTTCATACTGTGTCTGTATTTAATCTTTTTTTATGGAACCTGTTGCGCCTA
TTTATGAAATAATAAATATAGGTGTTTGTAAGTAAATTTGTTAGTATTTGAAAGAGGTTTCTTTGATGTTTTAACTTTTGCTGGCAAAAA
AAAATTCACGCTTGGTGTGAATACTTTATTATTTAGTTTTTACAGTAACATGAATAAAGCCAAACCTGCTTTTCATTTAGCAGCAAATTA
AAGTAACCAGTCCTTATTTCTGCATTTCTTTGGTTGATGCAAACAAAAAACTATTATATTTAAGAACTTTATTTCTTCATACGACATAAC
AGAATTGCCCTCCAAGTCACACAAGCTCCAAGACTAAACAAACAGACAGGTCCTCTGTCTTAAAAAGGTTACTTCTTGGTTCTCAGCTGG
TTCTAGTCAATTCTGAACCACCACCCCCCGCCCCCCGCAAAAAAGTAAAAGTCAAACCAAACTTCCTCAAGCTGCATGCTTTTCACAAAA
TCCAGAAAGCATTTAAGAATTGAACTAGGGGCTGGAAGAAGTGAAAGGGAAGCATCTAAAAATGAAAGGTGAGTAACCAGATAGCAAAAG
AAAAGGGAAAGCCATCCAAATTTGAAAGCTGTTGATAGAAATTGAGATTCTTGCTGTCTTTTGTGCCTCTACAAGCTACTACTCATTCCA
GAATTCCTGGGTCTTCCAAGAGGATTCTTAAGGTACCAGAGATTTGCTAGGGAACCAAAAGTGCTTGAGAATCTGCCTGAGGGCTTGCAT
AGCTTTCACATTAAAAAAAGAAAAAGCTAGCAGATTTACTCCTTTTTAGGGGATCATATCAAGAAAGTTAGTCTGGTTGGAAACCAAGAG
AATGGCTGATGTCTCTTTCTTGGAATATGTGAAATAAATTTAGCAGTTTAACTAAATACAAATATATGCATTGTGTAATCCACTCAGAAT
TAAACAGACAAAAGGTATGCTTGCTTTGGAATGATTTTAGGCATTGTACAACCTTGAATCACTTGAGCATGTAATAACTAATAAATAATG
CAGATCCATGTGATTATTAAAATGACTGTAGCTGAGAGCTCTAATTTTCCTGTCTTGAAACTGTATAAGAACTCATGTGATTAAGTTCAC
AGTTTATTGTTTGTCTGTTTAGTATTTTAGAAATATACCAGCACTACTAATTAACTAATGTCTTTTATTTATTATATTATGATAAAGTAA
AAATTTCACTTGCATTAAGTCTAAACTGAGAAGGTAATTACTGGGAGGAGAATGAGCAGCTTTGACTTTGACAGGCGGTTTGTGCAGGAA
AGCACAGTGCCGTGTTGTTTACAGCTTTTCTAGAGCAGCTGTGCGACCAGGGTAGAGAGTGTTGAAATTCAATACCAAATACAGTAAAAA

>16383_16383_2_CHD7-TOX_CHD7_chr8_61655656_ENST00000524602_TOX_chr8_59872567_ENST00000361421_length(amino acids)=1058AA_BP=565
MWFGGAVCWKKMADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTNQNQTKLTHFDHYNQYEQQK
MHLMDQPNRMMSNTPGNGLASPHSQYHTPPVPQVPHGGSGGGQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQP
PQPAPSGPPAQGHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQQSPSMAPSLRHSVQQFHHH
PSTALHGESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPN
AVGFPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGIPMEVGSYPNMPHPQPSHQP
PGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHMRPNGCPGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSP
PHPHHQPWAQLHPSPQNTPQKVPVHQFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCH
PMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLS
AQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAA
IKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSA
LYLSSHYHQQPGMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALH

--------------------------------------------------------------
>16383_16383_3_CHD7-TOX_CHD7_chr8_61655656_ENST00000525508_TOX_chr8_59872567_ENST00000361421_length(transcript)=5473nt_BP=1665nt
ATGGCAGATCCAGGAATGATGAGTCTTTTTGGCGAGGATGGGAATATTTTCAGTGAAGGTCTTGAAGGCCTCGGAGAATGTGGTTACCCG
GAAAATCCAGTAAATCCTATGGGTCAGCAAATGCCAATAGACCAAGGCTTTGCCTCTTTACAGCCATCCCTTCATCATCCTTCAACTAAT
CAAAATCAAACAAAGCTGACACATTTTGATCACTATAATCAGTATGAACAACAAAAGATGCATCTGATGGATCAGCCGAACAGAATGATG
AGCAACACCCCTGGGAACGGACTCGCGTCTCCGCACTCGCAGTATCACACCCCTCCCGTTCCTCAGGTGCCCCATGGTGGCAGTGGTGGC
GGTCAGATGGGTGTCTACCCTGGCATGCAGAATGAGAGGCATGGGCAATCCTTTGTGGACAGCAGCTCCATGTGGGGCCCCAGGGCTGTT
CAGGTACCAGACCAGATACGAGCCCCCTACCAGCAGCAGCAGCCACAGCCGCAGCCACCGCAGCCGGCTCCGTCGGGGCCCCCTGCACAG
GGCCACCCTCAGCACATGCAGCAGATGGGCAGCTATATGGCACGTGGGGATTTTTCCATGCAGCAGCATGGTCAGCCACAGCAGAGGATG
AGCCAGTTTTCCCAAGGCCAAGAGGGCCTCAATCAGGGAAATCCTTTTATTGCCACCTCAGGACCTGGCCACTTGTCCCACGTGCCCCAG
CAGAGTCCCAGCATGGCACCTTCCTTGCGTCACTCGGTGCAGCAGTTCCATCACCACCCCTCTACTGCTCTCCATGGAGAATCCGTTGCC
CACAGTCCCAGATTCTCCCCGAATCCTCCCCAACAAGGGGCTGTTAGGCCGCAAACCCTTAACTTTAGTTCTCGGAGCCAGACAGTCCCC
TCTCCTACTATAAACAACTCAGGGCAGTATTCTCGATATCCTTACAGTAACCTAAATCAGGGATTAGTTAACAATACAGGGATGAATCAA
AATTTAGGCCTTACAAATAATACTCCAATGAATCAGTCCGTACCAAGATACCCCAATGCTGTAGGATTCCCATCAAACAGTGGTCAAGGA
CTAATGCACCAGCAGCCCATCCACCCCAGTGGCTCACTTAACCAAATGAACACACAAACTATGCATCCTTCACAGCCTCAGGGAACTTAT
GCCTCTCCACCTCCCATGTCACCCATGAAAGCAATGAGTAATCCAGCAGGCACTCCTCCTCCACAAGTCAGGCCGGGAAGTGCTGGGATA
CCAATGGAAGTTGGCAGTTATCCAAATATGCCCCATCCTCAGCCATCTCACCAGCCCCCTGGTGCCATGGGAATCGGACAGAGGAATATG
GGCCCCAGAAACATGCAGCAGTCTCGTCCATTTATAGGCATGTCCTCGGCACCAAGGGAATTGACTGGGCACATGAGGCCAAATGGTTGT
CCTGGTGTTGGCCTTGGAGACCCACAAGCAATCCAGGAACGACTGATACCTGGCCAACAACATCCTGGTCAACAGCCATCTTTTCAGCAG
TTGCCAACCTGTCCTCCACTGCAGCCTCACCCGGGCTTGCACCACCAGTCTTCACCTCCACACCCTCATCACCAGCCTTGGGCACAGCTC
CACCCATCACCCCAGAACACCCCGCAGAAAGTGCCTGTGCATCAGTTTGACGGTGAGAACATGTATATGAGCATGACAGAGCCGAGCCAG
GACTATGTGCCAGCCAGCCAGTCCTACCCTGGTCCAAGCCTGGAAAGTGAAGACTTCAACATTCCACCAATTACTCCTCCTTCCCTCCCA
GACCACTCGCTGGTGCACCTGAATGAAGTTGAGTCTGGTTACCATTCTCTGTGTCACCCCATGAACCATAATGGCCTGCTACCATTTCAT
CCACAAAACATGGACCTCCCTGAAATCACAGTCTCCAATATGCTGGGCCAGGATGGAACACTGCTTTCTAATTCCATTTCTGTGATGCCA
GATATACGAAACCCAGAAGGAACTCAGTACAGTTCCCATCCTCAGATGGCAGCCATGAGACCAAGGGGCCAGCCTGCAGACATCAGGCAG
CAGCCAGGAATGATGCCACATGGCCAGCTGACTACCATTAACCAGTCACAGCTAAGTGCTCAACTTGGTTTGAATATGGGAGGAAGCAAT
GTTCCCCACAACTCACCATCTCCACCTGGAAGCAAGTCTGCAACTCCTTCACCATCCAGTTCAGTGCATGAAGATGAAGGCGATGATACC
TCTAAGATCAATGGTGGAGAGAAGCGGCCTGCCTCTGATATGGGGAAAAAACCAAAAACTCCCAAAAAGAAGAAGAAGAAGGATCCCAAT
GAGCCCCAGAAGCCTGTGTCTGCCTATGCGTTATTCTTTCGTGATACTCAGGCCGCCATCAAGGGCCAAAATCCAAACGCTACCTTTGGC
GAAGTCTCTAAAATTGTGGCTTCAATGTGGGACGGTTTAGGAGAAGAGCAAAAACAGGTCTATAAAAAGAAAACCGAGGCTGCGAAGAAG
GAGTACCTGAAGCAACTCGCAGCATACAGAGCCAGCCTTGTATCCAAGAGCTACAGTGAACCTGTTGACGTGAAGACATCTCAACCTCCT
CAGCTGATCAATTCGAAGCCGTCGGTGTTCCATGGGCCCAGCCAGGCCCACTCGGCCCTGTACCTAAGTTCCCACTATCACCAACAACCG
GGAATGAATCCTCACCTAACTGCCATGCATCCTAGTCTCCCCAGGAACATAGCCCCCAAGCCGAATAACCAAATGCCAGTGACTGTCTCT
ATAGCAAACATGGCTGTGTCCCCTCCTCCTCCCCTCCAGATCAGCCCGCCTCTTCACCAGCATCTCAACATGCAGCAGCACCAGCCGCTC
ACCATGCAGCAGCCCCTTGGGAACCAGCTCCCCATGCAGGTCCAGTCTGCCTTACACTCACCCACCATGCAGCAAGGATTTACTCTTCAA
CCCGACTATCAGACTATTATCAATCCTACATCTACAGCTGCACAAGTTGTCACCCAGGCAATGGAGTATGTGCGTTCGGGGTGCAGAAAT
CCTCCCCCACAACCGGTGGACTGGAATAACGACTACTGCAGTAGTGGGGGCATGCAGAGGGACAAAGCACTGTACCTTACTTGAGAATCT
GAACACCTCTTCTTTCCACTGAGGAATTCAGGGAAGTGTTTTCACCATGGATTGCTTTGTACAGTCAAGGCAGTTCTCCATTTTATTAGA
AAATACAAGTTGCTAAGCACTTAGGACCATTTGAGCTTGTGGGTCACCCACTCTGGAAGAAATAGTCATGCTTCTTTATTATTTTTTTAA
TCCTTTATGGACATTGTTTTTCTTCTTCCCTGAAGGAAATTTGGACCATTCAGATTTTATGTTGGTTTTTTGCTGTGAAGTGCTGCGCTC
TAGTAACTGCCTTAGCAACTGTAGATGTCTCGGATAAAAGTCCTGGATTTTCCATTGGTTTTCATAATGGGTGTTTATATGAAACTACTA
AAGACTTTTTAAATGGCTTGATGTAGCAGTCATAGCAAGTTTGTAAATAGCATCTATGTTACACTCTCCTAGAGTATAAAATGTGAATGT
TTTTGTAGCTAAATTGTAATTGAAACTGGCTCATTCCAGTTTATTGATTTCACAATAGGGGTTAAATTGGCAAACATTCATATTTTTACT
TCATTTTTAAAACAACTGACTGATAGTTCTATATTTTCAAAATATTTGAAAATAAAAAGTATTCCCAAGTGATTTTAATTTAAAAACAAA
TTGGCTTTGTCTCATTGATCAGACAAAAAGAAACTAGTATTAAGGGAAGCGCAAACACATTTATTTTGTACTGCAGAAAAATTGCTTTTT
TGTATCACTTTTTGTGTAATGGTTAGTAAATGTCATTTAAGTCCTTTTATGTATAAAACTGCCAAATGCTTACCTGGTATTTTATTAGAT
GCAGAAACAGATTGGAAACAGCTAAATTACAACTTTTACATATGGCTCTGTCTTATTGTTTCTTCATACTGTGTCTGTATTTAATCTTTT
TTTATGGAACCTGTTGCGCCTATTTATGAAATAATAAATATAGGTGTTTGTAAGTAAATTTGTTAGTATTTGAAAGAGGTTTCTTTGATG
TTTTAACTTTTGCTGGCAAAAAAAAATTCACGCTTGGTGTGAATACTTTATTATTTAGTTTTTACAGTAACATGAATAAAGCCAAACCTG
CTTTTCATTTAGCAGCAAATTAAAGTAACCAGTCCTTATTTCTGCATTTCTTTGGTTGATGCAAACAAAAAACTATTATATTTAAGAACT
TTATTTCTTCATACGACATAACAGAATTGCCCTCCAAGTCACACAAGCTCCAAGACTAAACAAACAGACAGGTCCTCTGTCTTAAAAAGG
TTACTTCTTGGTTCTCAGCTGGTTCTAGTCAATTCTGAACCACCACCCCCCGCCCCCCGCAAAAAAGTAAAAGTCAAACCAAACTTCCTC
AAGCTGCATGCTTTTCACAAAATCCAGAAAGCATTTAAGAATTGAACTAGGGGCTGGAAGAAGTGAAAGGGAAGCATCTAAAAATGAAAG
GTGAGTAACCAGATAGCAAAAGAAAAGGGAAAGCCATCCAAATTTGAAAGCTGTTGATAGAAATTGAGATTCTTGCTGTCTTTTGTGCCT
CTACAAGCTACTACTCATTCCAGAATTCCTGGGTCTTCCAAGAGGATTCTTAAGGTACCAGAGATTTGCTAGGGAACCAAAAGTGCTTGA
GAATCTGCCTGAGGGCTTGCATAGCTTTCACATTAAAAAAAGAAAAAGCTAGCAGATTTACTCCTTTTTAGGGGATCATATCAAGAAAGT
TAGTCTGGTTGGAAACCAAGAGAATGGCTGATGTCTCTTTCTTGGAATATGTGAAATAAATTTAGCAGTTTAACTAAATACAAATATATG
CATTGTGTAATCCACTCAGAATTAAACAGACAAAAGGTATGCTTGCTTTGGAATGATTTTAGGCATTGTACAACCTTGAATCACTTGAGC
ATGTAATAACTAATAAATAATGCAGATCCATGTGATTATTAAAATGACTGTAGCTGAGAGCTCTAATTTTCCTGTCTTGAAACTGTATAA
GAACTCATGTGATTAAGTTCACAGTTTATTGTTTGTCTGTTTAGTATTTTAGAAATATACCAGCACTACTAATTAACTAATGTCTTTTAT
TTATTATATTATGATAAAGTAAAAATTTCACTTGCATTAAGTCTAAACTGAGAAGGTAATTACTGGGAGGAGAATGAGCAGCTTTGACTT
TGACAGGCGGTTTGTGCAGGAAAGCACAGTGCCGTGTTGTTTACAGCTTTTCTAGAGCAGCTGTGCGACCAGGGTAGAGAGTGTTGAAAT

>16383_16383_3_CHD7-TOX_CHD7_chr8_61655656_ENST00000525508_TOX_chr8_59872567_ENST00000361421_length(amino acids)=1047AA_BP=554
MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTNQNQTKLTHFDHYNQYEQQKMHLMDQPNRMM
SNTPGNGLASPHSQYHTPPVPQVPHGGSGGGQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQ
GHPQHMQQMGSYMARGDFSMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQQSPSMAPSLRHSVQQFHHHPSTALHGESVA
HSPRFSPNPPQQGAVRPQTLNFSSRSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAVGFPSNSGQG
LMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGSAGIPMEVGSYPNMPHPQPSHQPPGAMGIGQRNM
GPRNMQQSRPFIGMSSAPRELTGHMRPNGCPGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQSSPPHPHHQPWAQL
HPSPQNTPQKVPVHQFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFH
PQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSN
VPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFG
EVSKIVASMWDGLGEEQKQVYKKKTEAAKKEYLKQLAAYRASLVSKSYSEPVDVKTSQPPQLINSKPSVFHGPSQAHSALYLSSHYHQQP
GMNPHLTAMHPSLPRNIAPKPNNQMPVTVSIANMAVSPPPPLQISPPLHQHLNMQQHQPLTMQQPLGNQLPMQVQSALHSPTMQQGFTLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHD7-TOX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHD7-TOX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHD7-TOX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource