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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHEK1-EXOC6 (FusionGDB2 ID:16416)

Fusion Gene Summary for CHEK1-EXOC6

check button Fusion gene summary
Fusion gene informationFusion gene name: CHEK1-EXOC6
Fusion gene ID: 16416
HgeneTgene
Gene symbol

CHEK1

EXOC6

Gene ID

1111

54536

Gene namecheckpoint kinase 1exocyst complex component 6
SynonymsCHK1EXOC6A|SEC15|SEC15L|SEC15L1|SEC15L3|Sec15p
Cytomap

11q24.2

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Chk1CHK1 checkpoint homologCheckpoint, S. pombe, homolog of, 1Chk1-Scell cycle checkpoint kinaseexocyst complex component 6SEC15-like 1SEC15-like protein 3exocyst complex component Sec15Arsec15-like protein
Modification date2020031320200313
UniProtAcc

O14757

Q9Y2D4

Ensembl transtripts involved in fusion geneENST00000532449, ENST00000278916, 
ENST00000427383, ENST00000428830, 
ENST00000438015, ENST00000524737, 
ENST00000534070, ENST00000544373, 
ENST00000371547, ENST00000371552, 
ENST00000260762, ENST00000371543, 
ENST00000443748, ENST00000497262, 
Fusion gene scores* DoF score2 X 3 X 2=128 X 7 X 4=224
# samples 28
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHEK1 [Title/Abstract] AND EXOC6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHEK1(125507439)-EXOC6(94757231), # samples:1
CHEK1(125505428)-EXOC6(94757231), # samples:1
Anticipated loss of major functional domain due to fusion event.CHEK1-EXOC6 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CHEK1-EXOC6 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CHEK1-EXOC6 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CHEK1-EXOC6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CHEK1-EXOC6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHEK1

GO:0000077

DNA damage checkpoint

16963448

HgeneCHEK1

GO:0006915

apoptotic process

23028632

HgeneCHEK1

GO:0006975

DNA damage induced protein phosphorylation

16963448

HgeneCHEK1

GO:0010569

regulation of double-strand break repair via homologous recombination

15665856

HgeneCHEK1

GO:0018107

peptidyl-threonine phosphorylation

15665856

HgeneCHEK1

GO:0045787

positive regulation of cell cycle

26296656

HgeneCHEK1

GO:0045839

negative regulation of mitotic nuclear division

15311285

HgeneCHEK1

GO:0046602

regulation of mitotic centrosome separation

15311285


check buttonFusion gene breakpoints across CHEK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EXOC6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-1665-01BCHEK1chr11

125505428

-EXOC6chr10

94757231

+
ChimerDB4OVTCGA-09-1665-01BCHEK1chr11

125507439

+EXOC6chr10

94757231

+


Top

Fusion Gene ORF analysis for CHEK1-EXOC6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000532449ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
3UTR-3CDSENST00000532449ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
3UTR-3CDSENST00000532449ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
3UTR-3CDSENST00000532449ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
3UTR-intronENST00000532449ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000278916ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000427383ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000428830ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000438015ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000524737ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000534070ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000260762CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000260762CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000371543CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000371543CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000443748CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000443748CHEK1chr11

125507439

+EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000497262CHEK1chr11

125505428

-EXOC6chr10

94757231

+
5CDS-intronENST00000544373ENST00000497262CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000278916ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000278916ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000278916ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000278916ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000427383ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000427383ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000427383ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000427383ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000428830ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000428830ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000428830ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000428830ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000438015ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000438015ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000438015ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000438015ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000524737ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000524737ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000524737ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000524737ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000534070ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000534070ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000534070ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000534070ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000544373ENST00000371547CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000544373ENST00000371547CHEK1chr11

125507439

+EXOC6chr10

94757231

+
Frame-shiftENST00000544373ENST00000371552CHEK1chr11

125505428

-EXOC6chr10

94757231

+
Frame-shiftENST00000544373ENST00000371552CHEK1chr11

125507439

+EXOC6chr10

94757231

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CHEK1-EXOC6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHEK1chr11125507439+EXOC6chr1094757230+6.83E-060.9999932
CHEK1chr11125507439+EXOC6chr1094757230+6.83E-060.9999932

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CHEK1-EXOC6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:125507439/:94757231)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHEK1

O14757

EXOC6

Q9Y2D4

FUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). May also negatively regulate cell cycle progression during unperturbed cell cycles (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Recognizes the substrate consensus sequence [R-X-X-S/T] (PubMed:11535615, PubMed:12446774, PubMed:12399544, PubMed:14559997, PubMed:14988723, PubMed:15311285, PubMed:15665856, PubMed:15650047). Binds to and phosphorylates CDC25A, CDC25B and CDC25C (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889, PubMed:14559997). Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C (PubMed:9278511). Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A (PubMed:9278511, PubMed:12676583, PubMed:14681206, PubMed:12676925, PubMed:12759351, PubMed:19734889). Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A (PubMed:9278511, PubMed:19734889, PubMed:20090422). Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression (PubMed:9278511). Also phosphorylates NEK6 (PubMed:18728393). Binds to and phosphorylates RAD51 at 'Thr-309', which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination (PubMed:15665856). Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation (PubMed:10673501, PubMed:15659650, PubMed:16511572). Also promotes repair of DNA cross-links through phosphorylation of FANCE (PubMed:17296736). Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A (PubMed:12660173, PubMed:12955071). This may enhance chromatin assembly both in the presence or absence of DNA damage (PubMed:12660173, PubMed:12955071). May also play a role in replication fork maintenance through regulation of PCNA (PubMed:18451105). May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones (By similarity). Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes (By similarity). May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest (PubMed:17380128). Phosphorylates SPRTN, promoting SPRTN recruitment to chromatin (PubMed:31316063). Reduces replication stress and activates the G2/M checkpoint, by phosphorylating and inactivating PABIR1/FAM122A and promoting the serine/threonine-protein phosphatase 2A-mediated dephosphorylation and stabilization of WEE1 levels and activity (PubMed:33108758). {ECO:0000250|UniProtKB:O35280, ECO:0000269|PubMed:10673501, ECO:0000269|PubMed:11535615, ECO:0000269|PubMed:12399544, ECO:0000269|PubMed:12446774, ECO:0000269|PubMed:12660173, ECO:0000269|PubMed:12676583, ECO:0000269|PubMed:12676925, ECO:0000269|PubMed:12759351, ECO:0000269|PubMed:12955071, ECO:0000269|PubMed:14559997, ECO:0000269|PubMed:14681206, ECO:0000269|PubMed:14988723, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15650047, ECO:0000269|PubMed:15659650, ECO:0000269|PubMed:15665856, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:17296736, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:18451105, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:19734889, ECO:0000269|PubMed:20090422, ECO:0000269|PubMed:31316063, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:9278511}.; FUNCTION: [Isoform 2]: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition. {ECO:0000269|PubMed:22184239}.FUNCTION: Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CHEK1-EXOC6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHEK1-EXOC6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHEK1-EXOC6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHEK1-EXOC6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource