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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHEK2-THOC5 (FusionGDB2 ID:16420)

Fusion Gene Summary for CHEK2-THOC5

check button Fusion gene summary
Fusion gene informationFusion gene name: CHEK2-THOC5
Fusion gene ID: 16420
HgeneTgene
Gene symbol

CHEK2

THOC5

Gene ID

11200

8563

Gene namecheckpoint kinase 2THO complex 5
SynonymsCDS1|CHK2|HuCds1|LFS2|PP1425|RAD53|hCds1C22orf19|Fmip|PK1.3|fSAP79
Cytomap

22q12.1

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase Chk2CHK2 checkpoint homologcds1 homologcheckpoint-like protein CHK2THO complex subunit 5 homologFms-interacting proteinNF2/meningioma region protein pK1.3PP39.2functional spliceosome-associated protein 79hTREX90placental protein 39.2
Modification date2020032020200313
UniProtAcc

O96017

.
Ensembl transtripts involved in fusion geneENST00000382566, ENST00000328354, 
ENST00000348295, ENST00000382565, 
ENST00000382578, ENST00000382580, 
ENST00000402731, ENST00000403642, 
ENST00000404276, ENST00000405598, 
ENST00000544772, ENST00000464581, 
ENST00000397871, ENST00000397872, 
ENST00000397873, ENST00000490103, 
Fusion gene scores* DoF score3 X 3 X 3=276 X 6 X 4=144
# samples 36
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHEK2 [Title/Abstract] AND THOC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHEK2(29085123)-THOC5(29932727), # samples:2
Anticipated loss of major functional domain due to fusion event.CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
CHEK2-THOC5 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
CHEK2-THOC5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHEK2

GO:0006355

regulation of transcription, DNA-templated

12717439

HgeneCHEK2

GO:0006468

protein phosphorylation

12717439

HgeneCHEK2

GO:0006974

cellular response to DNA damage stimulus

24550317

HgeneCHEK2

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

12402044

HgeneCHEK2

GO:0042770

signal transduction in response to DNA damage

14744935

HgeneCHEK2

GO:0045893

positive regulation of transcription, DNA-templated

17101782

HgeneCHEK2

GO:0046777

protein autophosphorylation

16794575|18644861

HgeneCHEK2

GO:0050821

protein stabilization

12717439

TgeneTHOC5

GO:0006406

mRNA export from nucleus

17190602

TgeneTHOC5

GO:0030224

monocyte differentiation

19015024

TgeneTHOC5

GO:0046784

viral mRNA export from host cell nucleus

18974867


check buttonFusion gene breakpoints across CHEK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across THOC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NF-A4WX-01ACHEK2chr22

29085123

-THOC5chr22

29932727

-
ChimerDB4UCSTCGA-NF-A4WXCHEK2chr22

29085123

-THOC5chr22

29932727

-


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Fusion Gene ORF analysis for CHEK2-THOC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000382566ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
3UTR-3CDSENST00000382566ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000328354ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000328354ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000328354ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000328354ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000348295ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000348295ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000348295ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000348295ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382565ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382565ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382565ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382565ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382578ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382578ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382578ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382578ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382580ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382580ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382580ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000382580ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000402731ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000402731ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000402731ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000402731ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000403642ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000403642ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000403642ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000403642ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000404276ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000404276ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000404276ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000404276ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000405598ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000405598ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000405598ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
Frame-shiftENST00000405598ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
In-frameENST00000544772ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000397871CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000397872CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000397873CHEK2chr22

29085123

-THOC5chr22

29932727

-
intron-3CDSENST00000464581ENST00000490103CHEK2chr22

29085123

-THOC5chr22

29932727

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000544772CHEK2chr2229085123-ENST00000490103THOC5chr2229932727-6347231623173768483
ENST00000544772CHEK2chr2229085123-ENST00000397871THOC5chr2229932727-4058231623173768483
ENST00000544772CHEK2chr2229085123-ENST00000397872THOC5chr2229932727-4058231623173768483
ENST00000544772CHEK2chr2229085123-ENST00000397873THOC5chr2229932727-3868231623173768483

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000544772ENST00000490103CHEK2chr2229085123-THOC5chr2229932727-0.0009888250.99901116
ENST00000544772ENST00000397871CHEK2chr2229085123-THOC5chr2229932727-0.0024152470.9975847
ENST00000544772ENST00000397872CHEK2chr2229085123-THOC5chr2229932727-0.0024152470.9975847
ENST00000544772ENST00000397873CHEK2chr2229085123-THOC5chr2229932727-0.0025509760.997449

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Fusion Genomic Features for CHEK2-THOC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHEK2-THOC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:29085123/chr22:29932727)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHEK2

O96017

.
FUNCTION: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells. Promotes the CCAR2-SIRT1 association and is required for CCAR2-mediated SIRT1 inhibition (PubMed:25361978). {ECO:0000250|UniProtKB:Q9Z265, ECO:0000269|PubMed:10097108, ECO:0000269|PubMed:10724175, ECO:0000269|PubMed:11298456, ECO:0000269|PubMed:12402044, ECO:0000269|PubMed:12607004, ECO:0000269|PubMed:12717439, ECO:0000269|PubMed:12810724, ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:17380128, ECO:0000269|PubMed:17715138, ECO:0000269|PubMed:18317453, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:18728393, ECO:0000269|PubMed:20364141, ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:25619829, ECO:0000269|PubMed:9836640, ECO:0000269|PubMed:9889122}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHEK2chr22:29085123chr22:29932727ENST00000328354-1415113_175514544.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000328354-1415220_486514544.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000348295-1314113_175485515.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000348295-1314220_486485515.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382566-1314113_175493276.6666666666667DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382566-1314220_486493276.6666666666667DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382578-1213113_175423453.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382580-1516113_175557587.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382580-1516220_486557587.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000402731-1213113_175485515.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000402731-1213220_486485515.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000403642-1112113_175423453.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000404276-1314113_175514544.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000404276-1314220_486514544.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000405598-1516113_175514544.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000405598-1516220_486514544.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000544772-1516113_175293323.0DomainFHA
HgeneCHEK2chr22:29085123chr22:29932727ENST00000328354-1415227_234514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000328354-1415302_308514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000328354-1415351_352514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000348295-1314227_234485515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000348295-1314302_308485515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000348295-1314351_352485515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382566-1314227_234493276.6666666666667Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382566-1314302_308493276.6666666666667Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382566-1314351_352493276.6666666666667Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382578-1213227_234423453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382578-1213302_308423453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382578-1213351_352423453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382580-1516227_234557587.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382580-1516302_308557587.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382580-1516351_352557587.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000402731-1213227_234485515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000402731-1213302_308485515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000402731-1213351_352485515.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000403642-1112227_234423453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000403642-1112302_308423453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000403642-1112351_352423453.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000404276-1314227_234514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000404276-1314302_308514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000404276-1314351_352514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000405598-1516227_234514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000405598-1516302_308514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000405598-1516351_352514544.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000544772-1516227_234293323.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000328354-1415368_394514544.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000348295-1314368_394485515.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382566-1314368_394493276.6666666666667RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382578-1213368_394423453.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382580-1516368_394557587.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000402731-1213368_394485515.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000403642-1112368_394423453.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000404276-1314368_394514544.0RegionNote=T-loop/activation segment
HgeneCHEK2chr22:29085123chr22:29932727ENST00000405598-1516368_394514544.0RegionNote=T-loop/activation segment

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHEK2chr22:29085123chr22:29932727ENST00000382578-1213220_486423453.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000403642-1112220_486423453.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000544772-1516220_486293323.0DomainProtein kinase
HgeneCHEK2chr22:29085123chr22:29932727ENST00000544772-1516302_308293323.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000544772-1516351_352293323.0Nucleotide bindingNote=ATP
HgeneCHEK2chr22:29085123chr22:29932727ENST00000544772-1516368_394293323.0RegionNote=T-loop/activation segment
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978715207_10199684.0MotifNuclear localization signal
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978726217_10199684.0MotifNuclear localization signal
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978736217_10199684.0MotifNuclear localization signal
TgeneTHOC5chr22:29085123chr22:29932727ENST000004901035207_10199684.0MotifNuclear localization signal


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Fusion Gene Sequence for CHEK2-THOC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16420_16420_1_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000397871_length(transcript)=4058nt_BP=2316nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA
GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC
ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG
CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG

>16420_16420_1_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000397871_length(amino acids)=483AA_BP=1
MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI
EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT
TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS
HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT
AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK

--------------------------------------------------------------
>16420_16420_2_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000397872_length(transcript)=4058nt_BP=2316nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA
GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC
ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG
CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG

>16420_16420_2_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000397872_length(amino acids)=483AA_BP=1
MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI
EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT
TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS
HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT
AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK

--------------------------------------------------------------
>16420_16420_3_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000397873_length(transcript)=3868nt_BP=2316nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA

>16420_16420_3_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000397873_length(amino acids)=483AA_BP=1
MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI
EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT
TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS
HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT
AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK

--------------------------------------------------------------
>16420_16420_4_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000490103_length(transcript)=6347nt_BP=2316nt
CTTCCGCCAGCCAGATCCGTCCTCCCCTCTCGCAGGCCAGACCTCGACGTGTCTCTCGCCCGGGCCCGTTTCCCGAAACCGTCGCTCGTA
CCAGTCCATAAGGCTGAAGTAGTCTCGAGTGGGGTCAGGTGCCTGCAGCGCTCGGCACTGTGGGCAGAAGAACCTGTCCTCCCGCCCGGG
GCCCCATGGGCCGCCGCAGTTCCAACAGCGGGGATAATTGCTTCCCGCCTGCGACGCAGCATCGCAGCTTAGCGGTCTCCTTCTGGGAAC
CCCTGTCGGCCAAAACCCCCACACCCGGAGCAAAGCCCCGGCTCTCCCCCGCCACATCTGGCCGGCGGCCTATCTAGCCGTGGTCACTCG
TGGGGAAAAGCAAAGAGAGCGTCTAACCAGACTAATGTTGCTGATTGGCTGGGGAGTCGAGGGGGCGGGATCACCCGAGGGGAACCCGGG
TTCTAAGTTCCGCTCTCCCTTCTAAACTACAACTCCCAGGAGGCATTGAGGCGGCGCCTGACGGCCACATCTGCTGCTCCTCATTGGTCC
GGCGGCAGGGGAGGGGGTTTTGATTGGCTGAGGGTGGAGTTTGTATCTGCAGGTTTAGCGCCACTCTGCTGGCTGAGGCTGCGGAGAGTG
TGCGGCTCCAGGTGGGCTCACGCGGTCGTGATGTCTCGGGAGTCGGATGTTGAGGCTCAGCAGTCTCATGGCAGCAGTGCCTGTTCACAG
CCCCATGGCAGCGTTACCCAGTCCCAAGGCTCCTCCTCACAGTCCCAGGGCATATCCAGCTCCTCTACCAGCACGATGCCAAACTCCAGC
CAGTCCTCTCACTCCAGCTCTGGGACACTGAGCTCCTTAGAGACAGTGTCCACTCAGGAACTCTATTCTATTCCTGAGGACCAAGAACCT
GAGGACCAAGAACCTGAGGAGCCTACCCCTGCCCCCTGGGCTCGATTATGGGCCCTTCAGGATGGATTTGCCAATCTTGAATGTGTGAAT
GACAACTACTGGTTTGGGAGGGACAAAAGCTGTGAATATTGCTTTGATGAACCACTGCTGAAAAGAACAGATAAATACCGAACATACAGC
AAGAAACACTTTCGGATTTTCAGGGAAGTGGGTCCTAAAAACTCTTACATTGCATACATAGAAGATCACAGTGGCAATGGAACCTTTGTA
AATACAGAGCTTGTAGGGAAAGGAAAACGCCGTCCTTTGAATAACAATTCTGAAATTGCACTGTCACTAAGCAGAAATAAAGAGAAAATA
CTTAAAATCTACTCTCTCAGCTGATTTTCAAAAATACGGCGGGGCGCGGTGGCTCACGTCTTTAATCCCAGCACTTTGGGAGGCCGAGGC
TGGCAGATCACCTGAGTTTTTGTCTTTTTTGATCTGACTGTAGATGATCAGTCAGTTTATCCTAAGGCATTAAGAGATGAATACATCATG
TCAAAAACTCTTGGAAGTGGTGCCTGTGGAGAGGTAAAGCTGGCTTTCGAGAGGAAAACATGTAAGAAAGTAGCCATAAAGATCATCAGC
AAAAGGAAGTTTGCTATTGGTTCAGCAAGAGAGGCAGACCCAGCTCTCAATGTTGAAACAGAAATAGAAATTTTGAAAAAGCTAAATCAT
CCTTGCATCATCAAGATTAAAAACTTTTTTGATGCAGAAGATTATTATATTGTTTTGGAATTGATGGAAGGGGGAGAGCTGTTTGACAAA
GTGGTGGGGAATAAACGCCTGAAAGAAGCTACCTGCAAGCTCTATTTTTACCAGATGCTCTTGGCTGTGCAGTACCTTCATGAAAACGGT
ATTATACACCGTGACTTAAAGCCAGAGAATGTTTTACTGTCATCTCAAGAAGAGGACTGTCTTATAAAGATTACTGATTTTGGGCACTCC
AAGATTTTGGGAGAGACCTCTCTCATGAGAACCTTATGTGGAACCCCCACCTACTTGGCGCCTGAAGTTCTTGTTTCTGTTGGGACTGCT
GGGTATAACCGTGCTGTGGACTGCTGGAGTTTAGGAGTTATTCTTTTTATCTGCCTTAGTGGGTATCCACCTTTCTCTGAGCATAGGACT
CAAGTGTCACTGAAGGATCAGATCACCAGTGGAAAATACAACTTCATTCCTGAAGTCTGGGCAGAAGTCTCAGAGAAAGCTCTGGACCTT
GTCAAGAAGTTGTTGGTAGTGGATCCAAAGGCACGTTTTACGACAGAAGAAGCCTTAAGACACCCGTGGCTTCAGGATGAAGACATGAAG
AGAAAGTTTCAAGATCTTCTGTCTGAGGAAAATGAATCCACAGCTCTACCCCAGGTTCTAGCCCAGGCTGGCAGAGAAGTACCGAGAGTG
CCTATCTAACAAGGAGAAGATTCTCAAGGAGATTGAGGTGAAGAAGGAGTACCTGAGCAGCCTCCAGCCCCGCCTCAACAGCATCATGCA
GGCTTCCCTTCCGGTGCAGGAGTACCTGTTTATGCCATTCGACCAGGCTCACAAGCAGTATGAGACAGCCAGACACCTGCCGCCTCCCCT
CTATGTCCTCTTTGTTCAGGCCACTGCGTATGGGCAGGCCTGTGATAAGACGTTATCTGTGGCAATCGAAGGCAGTGTGGATGAAGCCAA
GGCTCTGTTCAAACCTCCAGAGGACTCCCAAGATGACGAGAGTGACTCAGATGCCGAGGAGGAGCAGACTACGAAGCGCCGGAGACCCAC
ACTGGGGGTTCAGTTGGACGACAAACGCAAGGAGATGCTGAAGAGGCACCCACTGTCTGTCATGCTCGACCTGAAGTGCAAAGATGACAG
TGTGCTTCACCTGACTTTCTACTACCTCATGAACCTCAACATCATGACAGTAAAAGCCAAAGTGACAACTGCCATGGAGCTGATCACCCC
CATCAGTGCAGGTGACTTGCTGTCTCCTGACTCAGTCCTGAGTTGCTTGTATCCTGGGGATCATGGAAAGAAAACTCCGAATCCAGCCAA
TCAGTATCAGTTTGATAAAGTTGGCATCCTGACTTTGAGCGACTATGTACTTGAGCTAGGTCACCCCTATTTGTGGGTGCAGAAGCTGGG
TGGCCTCCACTTCCCCAAAGAGCAGCCCCAGCAAACAGTGATTGCTGACCACTCGCTGAGCGCCAGCCACATGGAGACCACCATGAAACT
TCTGAAGACCAGGGTGCAGTCCCGCCTGGCCCTCCACAAACAGTTTGCATCCCTAGAACATGGCATTGTGCCAGTTACCAGTGATTGCCA
GTACCTCTTCCCTGCCAAGGTTGTCTCTCGCCTGGTGAAATGGGTGACAGTTGCCCATGAGGATTACATGGAGCTGCACTTCACCAAAGA
CATTGTGGATGCGGGACTGGCTGGGGACACCAATCTCTACTACATGGCGCTCATCGAAAGGGGCACAGCCAAACTGCAGGCCGCTGTGGT
GTTGAACCCTGGCTACTCCTCCATCCCACCTGTTTTCCAGCTCTGTTTGAACTGGAAAGGGGAGAAAACCAACAGCAACGATGACAACAT
TCGGGCCATGGAGGGCGAAGTCAATGTGTGCTACAAGGAGCTGTGTGGCCCTTGGCCCAGCCACCAGCTGTTGACCAACCAGCTGCAGCG
GCTGTGTGTGCTGCTGGATGTTTACCTGGAGACCGAGAGCCATGACGACAGTGTGGAGGGGCCCAAGGAATTTCCCCAGGAGAAGATGTG
TCTGCGGCTCTTCAGGGGTCCTAGCAGGATGAAGCCATTTAAATACAACCATCCTCAGGGATTCTTCAGCCATCGCTGATCTCCCGCGCA
GACCGTTGTTTCCCCCAAGGCCTCACCCTGAGCACTGGGCTTCTGCTTTCTGCTCTGGCCCACATGTGACTCTTGATATTCTCCAAAGAC
ACCAGCCAATTAAAAAGCGTCACCTGACCAGTGGCCTTTGTCTGTGGTTCCTGGCAAGGTGGCTTTGCAGTCTGGAAGGGCAGGTGGGAG
CTGTGACACAGTGTGAAAAAGCATTTGTAGAGAGACTTTTTCTCAGCAGCCAATAAAAGCAGAGTGGAAAAAGATTCCAATTCTGCAGAG
AGATGCTCACCTCTTGTCTACGCACACCCTATTTGTGCTTTGCGGGGTGAGGTCCTCATGATCTTGTATTTATTATCCCAAGTTCCTGCT
GTTAAGAGGTGGTAGGAGAAGCCAAAGGCAGCAGAGCACAAAAAGCAAAACTCTTCCCTCCCCACCCGCTCTTCCCATTAGTCCTGTCAG
GGTTGCCGATGGACAAATTGTCTCTGATCGTTGGATGTTATAAATGTCTGACAGTGCAGTGCAAACAGAAGACAAACTCAGTTGATCCTT
GAACAACTCAGGGGTTAGGGGCACCAACACCCCCTGCCCTGCACAGTTGAAAAATCCGTGTATAACTTTTGACTCCCTAAAAACTTAACT
AATAGCCTGCTGTTGACCAGTAGTATGCTATTAGTAGTTACTTACTGCTAACATAGTCAGTACATATTTTCAGTATATATTTTGTATCTT
ATACACTGTATTCTTACAATACAGTAAACTAGAGAAAAGAAAATGTTATAAGGAAAGTCACAAGGGGGCCTGAGTGCAGTGGCTCACGTC
TGTAATCCCAGCACTTTGGGAGGCCAAGGCGGGTGGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCGACATGGTGAAACCCTGT
CTCTACTAAAAACATGGAAATTAGCCAAGCGTGGTGGCGCATGCCTGTAGTCCCAGTTACTCAGGAGGCTGAGGCAGAATTACTTGAACC
CATGAGGCAGAGGTTGCAGTAAGCCAAGATCACGCTCCTGCGCTCCGGCTTGGGCGAGAGTGAGACTCCGTCTCAAAAATAAATAAATAA
GAAAGCCATAAGGAAGAAAATATATATCTACTATTAAGTAGAAGTGGATCACCATAAAGGTCTTCACATACTGTCTCAGGGTTGAATAGT
CTAAGGAAGAGGAGGGGTTGGTCTTGGTGTCTCAGGGATGGCAGAGGCAGAAAAAGTGGGGGAGGTGGAGGGGGAGGCAGGCACCACTGT
TATTTTTATTGAACAAAATCTGTGCAGGGACTCATGACTGTAATCCTAGTACTTTGGAAAGCTAAGGCGGGAGGATCCCTTGAGGCCAGG
AGTTCAGGTCCAGCCTGGGCAACGTAGTGAGAGACCCTGTATCTACAAAAAATTTAAAAATCAGCCAGGTGTGGTGGTATGCACCAATAG
TCCCAGTTACTCAGAAGGCTGAGGTGGGCGGATGACTGGAGTCCAGGAGTTCAAGGTAGCAGTGAGCTATTCATCGTGCCTGTACTGTAC
TCCAGCCTGGGAAACAATGCGAGTCCCTATCTCTAAAAAATTTTAAAAAAAGAAATCTGCATATAATAGACCCACAGAGTCCAAACTATT
GTTCAGAGATCAACTGTACTTCACAGAGAGTAATTCTAAGTCTTACAGGATTTCATGGAGATGGCGAGAGTGGTGTTGGAGAATCAATCA
CATACAGAGATACAGGACAGTGAGACCAGGTAACATTTGAGGAGAATATTTTTTTTTTATTGAGACAGGGTCTTGCTCTGTTGTCCAGGC
TGGAGTGCAGTGGCACGAACACAGCTCACTGCCGCCTCAACCTCTCCTGGGTTCAAGTGATCCTCCTGCCTCAGCCTCCCAAGTAGCTGG
GACCACAGGTGTGTGCCACCATTTCTGGCTAATTTTTAAATTTTTTGTAGAGGCGGGATCCCACTATTTTTCCCAGGCTGGTCTCAAACT
CCTGGGCTCAAATGATCCTCCCACCTCGGCCTCCCAAAGTGCTAGGATTATAGGCATGAGCCACCACACCCGGCCTGAGTAGAGTCTTTA
AGGTAATGACAAAAGTGCCTCAAAATATAATTATTTGATTAAGAGAAGTCTTGGGAAGATAGGTAACAACCTTTAAAATGTTCATAAAAT
TACATCCTTTGTAATACTCCTGCAAGTCAAAGTAAAGGATGGCATAGACTATTCTTGGACAGTTTTGTCAAAAAGTGTATCTTGACCCCA
CCATCAGTACTCCATTCTTCATTTTAAAAAATAAGATGGGCTGGGCACAGTGGCTTACGCCTTTAATATCAGTACTTTGGGAGGCTGGTG
GGCGGATCACCTGAGATCAGGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCTGGGCA
TGGTGGTGCGCGCCTGTAATCCCAGCCACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAATCCCCGAGGCGGAGGTTGCACTGAGCCGAG

>16420_16420_4_CHEK2-THOC5_CHEK2_chr22_29085123_ENST00000544772_THOC5_chr22_29932727_ENST00000490103_length(amino acids)=483AA_BP=1
MAEKYRECLSNKEKILKEIEVKKEYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAI
EGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVMLDLKCKDDSVLHLTFYYLMNLNIMTVKAKVT
TAMELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLSDYVLELGHPYLWVQKLGGLHFPKEQPQQTVIADHSLSAS
HMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQYLFPAKVVSRLVKWVTVAHEDYMELHFTKDIVDAGLAGDTNLYYMALIERGT
AKLQAAVVLNPGYSSIPPVFQLCLNWKGEKTNSNDDNIRAMEGEVNVCYKELCGPWPSHQLLTNQLQRLCVLLDVYLETESHDDSVEGPK

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Fusion Gene PPI Analysis for CHEK2-THOC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978715202_144199.66666666666666684.0CSF1R
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978726212_144199.66666666666666684.0CSF1R
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978736212_144199.66666666666666684.0CSF1R
TgeneTHOC5chr22:29085123chr22:29932727ENST000004901035202_144199.66666666666666684.0CSF1R
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978715202_199199.66666666666666684.0THOC7
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978726212_199199.66666666666666684.0THOC7
TgeneTHOC5chr22:29085123chr22:29932727ENST000003978736212_199199.66666666666666684.0THOC7
TgeneTHOC5chr22:29085123chr22:29932727ENST000004901035202_199199.66666666666666684.0THOC7


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHEK2-THOC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHEK2-THOC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource