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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHGA-PDE4A (FusionGDB2 ID:16443)

Fusion Gene Summary for CHGA-PDE4A

Fusion gene summary

Fusion gene information	Fusion gene name: CHGA-PDE4A
	Fusion gene ID: 16443
		Hgene	Tgene
	Gene symbol	CHGA	PDE4A
	Gene ID	1113	5141
	Gene name	chromogranin A	phosphodiesterase 4A
	Synonyms	CGA	DPDE2\|PDE4\|PDE46
	Cytomap	14q32.12	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	chromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein I	cAMP-specific 3',5'-cyclic phosphodiesterase 4Aphosphodiesterase 4A, cAMP-specific (duncephosphodiesterase E2 dunce homolog, Drosophilaphosphodiesterase isozyme 4
	Modification date	20200315	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000216492, ENST00000334654, ENST00000553866,	ENST00000344979, ENST00000352831, ENST00000380702, ENST00000592685, ENST00000293683, ENST00000440014,
Fusion gene scores	* DoF score	11 X 15 X 3=495	9 X 9 X 8=648
	# samples	15	12
	** MAII score	log2(15/495*10)=-1.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/648*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHGA [Title/Abstract] AND PDE4A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHGA(93399084)-PDE4A(10577651), # samples:1 PDE4A(10577669)-CHGA(93398897), # samples:1
Anticipated loss of major functional domain due to fusion event.	PDE4A-CHGA seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. PDE4A-CHGA seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PDE4A-CHGA seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CHGA-PDE4A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CHGA-PDE4A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CHGA-PDE4A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHGA	GO:0002551	mast cell chemotaxis	21214543
Hgene	CHGA	GO:0032762	mast cell cytokine production	21214543
Hgene	CHGA	GO:0033604	negative regulation of catecholamine secretion	15326220
Hgene	CHGA	GO:0043303	mast cell degranulation	21214543
Hgene	CHGA	GO:0045576	mast cell activation	21214543
Hgene	CHGA	GO:0050829	defense response to Gram-negative bacterium	15723172
Hgene	CHGA	GO:0050830	defense response to Gram-positive bacterium	15723172

Fusion gene breakpoints across CHGA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDE4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PCPG	TCGA-QT-A5XM-01A	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+

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Fusion Gene ORF analysis for CHGA-PDE4A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000216492	ENST00000344979	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000216492	ENST00000352831	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000216492	ENST00000380702	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000216492	ENST00000592685	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000334654	ENST00000344979	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000334654	ENST00000352831	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000334654	ENST00000380702	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
Frame-shift	ENST00000334654	ENST00000592685	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
In-frame	ENST00000216492	ENST00000293683	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
In-frame	ENST00000216492	ENST00000440014	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
In-frame	ENST00000334654	ENST00000293683	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
In-frame	ENST00000334654	ENST00000440014	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
intron-3CDS	ENST00000553866	ENST00000293683	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
intron-3CDS	ENST00000553866	ENST00000344979	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
intron-3CDS	ENST00000553866	ENST00000352831	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
intron-3CDS	ENST00000553866	ENST00000380702	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
intron-3CDS	ENST00000553866	ENST00000440014	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+
intron-3CDS	ENST00000553866	ENST00000592685	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000216492

CHGA

chr14

93399084

ENST00000293683

PDE4A

chr19

10577651

1846

1200

157

1845

563

ENST00000216492

CHGA

chr14

93399084

ENST00000440014

PDE4A

chr19

10577651

1846

1200

157

1845

563

ENST00000334654

CHGA

chr14

93399084

ENST00000293683

PDE4A

chr19

10577651

1297

651

1296

412

ENST00000334654

CHGA

chr14

93399084

ENST00000440014

PDE4A

chr19

10577651

1297

651

1296

412

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216492	ENST00000293683	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+	0.013839314	0.98616064
ENST00000216492	ENST00000440014	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+	0.013839314	0.98616064
ENST00000334654	ENST00000293683	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+	0.013130456	0.9868695
ENST00000334654	ENST00000440014	CHGA	chr14	93399084	+	PDE4A	chr19	10577651	+	0.013130456	0.9868695

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Fusion Genomic Features for CHGA-PDE4A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHGA-PDE4A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:93399084/chr19:10577651)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000293683

357_686

861.0

Domain

PDEase

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000344979

357_686

648.0

Domain

PDEase

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000352831

357_686

887.0

Domain

PDEase

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000380702

357_686

865.0

Domain

PDEase

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000440014

357_686

826.0

Domain

PDEase

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000592685

357_686

865.0

Domain

PDEase

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000293683

433_437

861.0

Nucleotide binding

cAMP

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000344979

433_437

648.0

Nucleotide binding

cAMP

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000352831

433_437

887.0

Nucleotide binding

cAMP

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000380702

433_437

865.0

Nucleotide binding

cAMP

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000440014

433_437

826.0

Nucleotide binding

cAMP

Tgene

PDE4A

chr14:93399084

chr19:10577651

ENST00000592685

433_437

865.0

Nucleotide binding

cAMP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHGA

chr14:93399084

chr19:10577651

ENST00000216492

181_191

458.0

Region

Note=O-glycosylated at one site only in cerebrospinal fluid

Hgene

CHGA

chr14:93399084

chr19:10577651

ENST00000216492

41_59

458.0

Region

Note=O-glycosylated at one site only in cerebrospinal fluid

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Fusion Gene Sequence for CHGA-PDE4A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16443_16443_1_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000216492_PDE4A_chr19_10577651_ENST00000293683_length(transcript)=1846nt_BP=1200nt
AAGGGGGCGGCACCGCTGACGTCATTTCCGGGGTCGGGGTATATAAGCGGGGCGCGAGGGCGCTGCTGCTGCCACCGCTCCTGCCACTGC
AGTGCTCGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGG
TGCCACCGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCC
CGGGTCCGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAA
AGGGGATACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTT
TGAGACACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGC
CAAGGAGAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCT
GAAAGAGGCGGTGGAAGAGCCATCATCCAAGGATGTTATGGAGAAAAGAGAGGATTCCAAGGAGGCAGAGAAAAGTGGTGAAGCCACAGA
CGGAGCCAGGCCCCAGGCCCTCCCGGAGCCCATGCAGGAGTCCAAGGCTGAGGGGAACAATCAGGCCCCTGGGGAGGAAGAGGAGGAGGA
GGAGGAGGCCACCAACACCCACCCTCCAGCCAGCCTCCCCAGCCAGAAATACCCAGGCCCACAGGCCGAGGGGGACAGTGAGGGCCTCTC
TCAGGGTCTGGTGGACAGAGAGAAGGGCCTGAGTGCAGAGCCAGGGTGGCAGGCAAAGAGAGAAGAGGAGGAGGAGGAGGAGGAGGAGGC
TGAGGCTGGAGAGGAGGCTGTCCCCGAGGAAGAAGGCCCCACTGTAGTGCTGAACCCCCACCCGAGCCTTGGCTACAAGGAGATCCGGAA
AGGCGAGACTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAG
GAGGAGGGCAGCGCAAACCGCAGACCAGAGGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGA
GGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAATATC
AATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTG
GGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACAGCA
GGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTC
TGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTCCAC
GGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATCCGC

>16443_16443_1_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000216492_PDE4A_chr19_10577651_ENST00000293683_length(amino acids)=563AA_BP=348
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA
EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE
EEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGETGGHPPGRTALRRACPSRSEATPRRRKRRRAAQTADQREDNRDWYYSAIR
QSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL
EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAG

--------------------------------------------------------------
>16443_16443_2_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000216492_PDE4A_chr19_10577651_ENST00000440014_length(transcript)=1846nt_BP=1200nt
AAGGGGGCGGCACCGCTGACGTCATTTCCGGGGTCGGGGTATATAAGCGGGGCGCGAGGGCGCTGCTGCTGCCACCGCTCCTGCCACTGC
AGTGCTCGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGG
TGCCACCGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCC
CGGGTCCGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAA
AGGGGATACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTT
TGAGACACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGC
CAAGGAGAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCT
GAAAGAGGCGGTGGAAGAGCCATCATCCAAGGATGTTATGGAGAAAAGAGAGGATTCCAAGGAGGCAGAGAAAAGTGGTGAAGCCACAGA
CGGAGCCAGGCCCCAGGCCCTCCCGGAGCCCATGCAGGAGTCCAAGGCTGAGGGGAACAATCAGGCCCCTGGGGAGGAAGAGGAGGAGGA
GGAGGAGGCCACCAACACCCACCCTCCAGCCAGCCTCCCCAGCCAGAAATACCCAGGCCCACAGGCCGAGGGGGACAGTGAGGGCCTCTC
TCAGGGTCTGGTGGACAGAGAGAAGGGCCTGAGTGCAGAGCCAGGGTGGCAGGCAAAGAGAGAAGAGGAGGAGGAGGAGGAGGAGGAGGC
TGAGGCTGGAGAGGAGGCTGTCCCCGAGGAAGAAGGCCCCACTGTAGTGCTGAACCCCCACCCGAGCCTTGGCTACAAGGAGATCCGGAA
AGGCGAGACTGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAG
GAGGAGGGCAGCGCAAACCGCAGACCAGAGGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGA
GGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAATATC
AATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTG
GGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACAGCA
GGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTC
TGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTCCAC
GGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATCCGC

>16443_16443_2_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000216492_PDE4A_chr19_10577651_ENST00000440014_length(amino acids)=563AA_BP=348
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA
EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE
EEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGETGGHPPGRTALRRACPSRSEATPRRRKRRRAAQTADQREDNRDWYYSAIR
QSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAEL
EAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAG

--------------------------------------------------------------
>16443_16443_3_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000334654_PDE4A_chr19_10577651_ENST00000293683_length(transcript)=1297nt_BP=651nt
CGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGGTGCCAC
CGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCCCGGGTC
CGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAAAGGGGA
TACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTTTGAGAC
ACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGCCAAGGA
GAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCTGAAAGC
TGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGC
AGCGCAAACCGCAGACCAGAGGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTC
AAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAATATCAATGGCCCA
GATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATC
CCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACAGCAGGCACAGTC
CACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGC
TCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTCCACGGCGGCCGA
GGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGC

>16443_16443_3_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000334654_PDE4A_chr19_10577651_ENST00000293683_length(amino acids)=412AA_BP=197
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKAGGHPPGRTALRRACPSRSEA
TPRRRKRRRAAQTADQREDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEA
LDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPG

--------------------------------------------------------------
>16443_16443_4_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000334654_PDE4A_chr19_10577651_ENST00000440014_length(transcript)=1297nt_BP=651nt
CGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGGTGCCAC
CGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCCCGGGTC
CGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAAAGGGGA
TACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTTTGAGAC
ACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGCCAAGGA
GAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCTGAAAGC
TGGAGGCCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGC
AGCGCAAACCGCAGACCAGAGGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACCCGAGGAGGAGTC
AAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAATATCAATGGCCCA
GATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGCCTGGGAGGCATC
CCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACAGCAGGCACAGTC
CACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCCCTCTGCCCTGGC
TCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTCCACGGCGGCCGA
GGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATCCGCACTCCCAGC

>16443_16443_4_CHGA-PDE4A_CHGA_chr14_93399084_ENST00000334654_PDE4A_chr19_10577651_ENST00000440014_length(amino acids)=412AA_BP=197
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKAGGHPPGRTALRRACPSRSEA
TPRRRKRRRAAQTADQREDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEA
LDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHGA-PDE4A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CHGA-PDE4A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CHGA-PDE4A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source