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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHGA-PENK (FusionGDB2 ID:16444)

Fusion Gene Summary for CHGA-PENK

check button Fusion gene summary
Fusion gene informationFusion gene name: CHGA-PENK
Fusion gene ID: 16444
HgeneTgene
Gene symbol

CHGA

PENK

Gene ID

1113

5179

Gene namechromogranin Aproenkephalin
SynonymsCGAPE|PENK-A
Cytomap

14q32.12

8q12.1

Type of geneprotein-codingprotein-coding
Descriptionchromogranin-ASP-Ibetagranin (N-terminal fragment of chromogranin A)catestatinchromofunginparathyroid secretory protein 1pituitary secretory protein Iproenkephalin-Aenkephalin Apeptide Fpreproenkephalin
Modification date2020031520200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000216492, ENST00000334654, 
ENST00000553866, 		ENST00000523274, 
ENST00000518770, ENST00000523051, 
ENST00000314922, ENST00000451791, 
Fusion gene scores* DoF score11 X 15 X 3=4956 X 6 X 4=144
# samples 157
** MAII scorelog2(15/495*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHGA [Title/Abstract] AND PENK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHGA(93399009)-PENK(57354134), # samples:1
CHGA(93398839)-PENK(57354105), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHGA

GO:0002551

mast cell chemotaxis

21214543

HgeneCHGA

GO:0032762

mast cell cytokine production

21214543

HgeneCHGA

GO:0033604

negative regulation of catecholamine secretion

15326220

HgeneCHGA

GO:0043303

mast cell degranulation

21214543

HgeneCHGA

GO:0045576

mast cell activation

21214543

HgeneCHGA

GO:0050829

defense response to Gram-negative bacterium

15723172

HgeneCHGA

GO:0050830

defense response to Gram-positive bacterium

15723172


check buttonFusion gene breakpoints across CHGA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PENK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PCPGTCGA-QR-A702-01ACHGAchr14

93398839

+PENKchr8

57354105

-
ChimerDB4PCPGTCGA-S7-A7WN-01ACHGAchr14

93399009

+PENKchr8

57354134

-


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Fusion Gene ORF analysis for CHGA-PENK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000216492ENST00000523274CHGAchr14

93398839

+PENKchr8

57354105

-
5CDS-5UTRENST00000216492ENST00000523274CHGAchr14

93399009

+PENKchr8

57354134

-
5CDS-5UTRENST00000334654ENST00000523274CHGAchr14

93398839

+PENKchr8

57354105

-
5CDS-5UTRENST00000334654ENST00000523274CHGAchr14

93399009

+PENKchr8

57354134

-
5CDS-intronENST00000216492ENST00000518770CHGAchr14

93398839

+PENKchr8

57354105

-
5CDS-intronENST00000216492ENST00000518770CHGAchr14

93399009

+PENKchr8

57354134

-
5CDS-intronENST00000216492ENST00000523051CHGAchr14

93398839

+PENKchr8

57354105

-
5CDS-intronENST00000216492ENST00000523051CHGAchr14

93399009

+PENKchr8

57354134

-
5CDS-intronENST00000334654ENST00000518770CHGAchr14

93398839

+PENKchr8

57354105

-
5CDS-intronENST00000334654ENST00000518770CHGAchr14

93399009

+PENKchr8

57354134

-
5CDS-intronENST00000334654ENST00000523051CHGAchr14

93398839

+PENKchr8

57354105

-
5CDS-intronENST00000334654ENST00000523051CHGAchr14

93399009

+PENKchr8

57354134

-
Frame-shiftENST00000216492ENST00000314922CHGAchr14

93398839

+PENKchr8

57354105

-
Frame-shiftENST00000216492ENST00000314922CHGAchr14

93399009

+PENKchr8

57354134

-
Frame-shiftENST00000334654ENST00000314922CHGAchr14

93398839

+PENKchr8

57354105

-
Frame-shiftENST00000334654ENST00000314922CHGAchr14

93399009

+PENKchr8

57354134

-
In-frameENST00000216492ENST00000451791CHGAchr14

93398839

+PENKchr8

57354105

-
In-frameENST00000216492ENST00000451791CHGAchr14

93399009

+PENKchr8

57354134

-
In-frameENST00000334654ENST00000451791CHGAchr14

93398839

+PENKchr8

57354105

-
In-frameENST00000334654ENST00000451791CHGAchr14

93399009

+PENKchr8

57354134

-
intron-3CDSENST00000553866ENST00000314922CHGAchr14

93398839

+PENKchr8

57354105

-
intron-3CDSENST00000553866ENST00000314922CHGAchr14

93399009

+PENKchr8

57354134

-
intron-3CDSENST00000553866ENST00000451791CHGAchr14

93398839

+PENKchr8

57354105

-
intron-3CDSENST00000553866ENST00000451791CHGAchr14

93399009

+PENKchr8

57354134

-
intron-5UTRENST00000553866ENST00000523274CHGAchr14

93398839

+PENKchr8

57354105

-
intron-5UTRENST00000553866ENST00000523274CHGAchr14

93399009

+PENKchr8

57354134

-
intron-intronENST00000553866ENST00000518770CHGAchr14

93398839

+PENKchr8

57354105

-
intron-intronENST00000553866ENST00000518770CHGAchr14

93399009

+PENKchr8

57354134

-
intron-intronENST00000553866ENST00000523051CHGAchr14

93398839

+PENKchr8

57354105

-
intron-intronENST00000553866ENST00000523051CHGAchr14

93399009

+PENKchr8

57354134

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216492CHGAchr1493399009+ENST00000451791PENKchr857354134-157912751571101314
ENST00000334654CHGAchr1493399009+ENST00000451791PENKchr857354134-103072661552163
ENST00000216492CHGAchr1493398839+ENST00000451791PENKchr857354105-172014451571218353
ENST00000334654CHGAchr1493398839+ENST00000451791PENKchr857354105-117189661669202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216492ENST00000451791CHGAchr1493399009+PENKchr857354134-0.0039999690.99600005
ENST00000334654ENST00000451791CHGAchr1493399009+PENKchr857354134-0.0133349640.986665
ENST00000216492ENST00000451791CHGAchr1493398839+PENKchr857354105-0.0059223610.9940777
ENST00000334654ENST00000451791CHGAchr1493398839+PENKchr857354105-0.0116686630.9883314

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Fusion Genomic Features for CHGA-PENK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHGA-PENK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:93399009/chr8:57354134)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHGAchr14:93398839chr8:57354105ENST00000216492+18181_1910458.0RegionNote=O-glycosylated at one site only in cerebrospinal fluid
HgeneCHGAchr14:93398839chr8:57354105ENST00000216492+1841_590458.0RegionNote=O-glycosylated at one site only in cerebrospinal fluid
HgeneCHGAchr14:93399009chr8:57354134ENST00000216492+18181_1910458.0RegionNote=O-glycosylated at one site only in cerebrospinal fluid
HgeneCHGAchr14:93399009chr8:57354134ENST00000216492+1841_590458.0RegionNote=O-glycosylated at one site only in cerebrospinal fluid


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Fusion Gene Sequence for CHGA-PENK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16444_16444_1_CHGA-PENK_CHGA_chr14_93398839_ENST00000216492_PENK_chr8_57354105_ENST00000451791_length(transcript)=1720nt_BP=1445nt
AAGGGGGCGGCACCGCTGACGTCATTTCCGGGGTCGGGGTATATAAGCGGGGCGCGAGGGCGCTGCTGCTGCCACCGCTCCTGCCACTGC
AGTGCTCGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGG
TGCCACCGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCC
CGGGTCCGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAA
AGGGGATACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTT
TGAGACACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGC
CAAGGAGAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCT
GAAAGAGGCGGTGGAAGAGCCATCATCCAAGGATGTTATGGAGAAAAGAGAGGATTCCAAGGAGGCAGAGAAAAGTGGTGAAGCCACAGA
CGGAGCCAGGCCCCAGGCCCTCCCGGAGCCCATGCAGGAGTCCAAGGCTGAGGGGAACAATCAGGCCCCTGGGGAGGAAGAGGAGGAGGA
GGAGGAGGCCACCAACACCCACCCTCCAGCCAGCCTCCCCAGCCAGAAATACCCAGGCCCACAGGCCGAGGGGGACAGTGAGGGCCTCTC
TCAGGGTCTGGTGGACAGAGAGAAGGGCCTGAGTGCAGAGCCAGGGTGGCAGGCAAAGAGAGAAGAGGAGGAGGAGGAGGAGGAGGAGGC
TGAGGCTGGAGAGGAGGCTGTCCCCGAGGAAGAAGGCCCCACTGTAGTGCTGAACCCCCACCCGAGCCTTGGCTACAAGGAGATCCGGAA
AGGCGAGAGTCCCGCAAGGCCTCTTCCGGGGTGGGAAGAGCGGAGAGCTGGAGCAGGAGGAGGAGCGGCTCTCCAAGGAGTGGGAGGACT
CCAAACGCTGGAGCAAGATGGACCAGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGAGGAGGAGGAGGACAACCGGG
ACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTGGAGGCCATCCTCCC
GGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGAC
CAGAGATAATGAGGAAGAAGTGAGCAAGAGATATGGGGGCTTCATGAGAGGCTTAAAGAGAAGCCCCCAACTGGAAGATGAAGCCAAAGA
GCTGCAGAAGCGATATGGGGGCTTCATGAGAAGAGTAGGTCGCCCAGAGTGGTGGATGGACTACCAGAAACGGTATGGAGGTTTCCTGAA
GCGCTTTGCCGAGGCTCTGCCCTCCGACGAAGAAGGCGAAAGTTACTCCAAAGAAGTTCCTGAAATGGAAAAAAGATACGGAGGATTTAT

>16444_16444_1_CHGA-PENK_CHGA_chr14_93398839_ENST00000216492_PENK_chr8_57354105_ENST00000451791_length(amino acids)=353AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA
EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE

--------------------------------------------------------------
>16444_16444_2_CHGA-PENK_CHGA_chr14_93398839_ENST00000334654_PENK_chr8_57354105_ENST00000451791_length(transcript)=1171nt_BP=896nt
CGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGGTGCCAC
CGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCCCGGGTC
CGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAAAGGGGA
TACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTTTGAGAC
ACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGCCAAGGA
GAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCTGAAAGG
TCCCGCAAGGCCTCTTCCGGGGTGGGAAGAGCGGAGAGCTGGAGCAGGAGGAGGAGCGGCTCTCCAAGGAGTGGGAGGACTCCAAACGCT
GGAGCAAGATGGACCAGCTGGCCAAGGAGCTGACGGCTGAGAAGCGGCTGGAGGGGCAGGAGGAGGAGGAGGACAACCGGGACAGTTCCA
TGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTGGAGGCCATCCTCCCGGGAGGACA
GCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGACCAGAGATAA
TGAGGAAGAAGTGAGCAAGAGATATGGGGGCTTCATGAGAGGCTTAAAGAGAAGCCCCCAACTGGAAGATGAAGCCAAAGAGCTGCAGAA
GCGATATGGGGGCTTCATGAGAAGAGTAGGTCGCCCAGAGTGGTGGATGGACTACCAGAAACGGTATGGAGGTTTCCTGAAGCGCTTTGC
CGAGGCTCTGCCCTCCGACGAAGAAGGCGAAAGTTACTCCAAAGAAGTTCCTGAAATGGAAAAAAGATACGGAGGATTTATGAGATTTTA

>16444_16444_2_CHGA-PENK_CHGA_chr14_93398839_ENST00000334654_PENK_chr8_57354105_ENST00000451791_length(amino acids)=202AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKGPARPLPGWEERRAGAGGGAA

--------------------------------------------------------------
>16444_16444_3_CHGA-PENK_CHGA_chr14_93399009_ENST00000216492_PENK_chr8_57354134_ENST00000451791_length(transcript)=1579nt_BP=1275nt
AAGGGGGCGGCACCGCTGACGTCATTTCCGGGGTCGGGGTATATAAGCGGGGCGCGAGGGCGCTGCTGCTGCCACCGCTCCTGCCACTGC
AGTGCTCGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGG
TGCCACCGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCC
CGGGTCCGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAA
AGGGGATACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTT
TGAGACACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGC
CAAGGAGAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCT
GAAAGAGGCGGTGGAAGAGCCATCATCCAAGGATGTTATGGAGAAAAGAGAGGATTCCAAGGAGGCAGAGAAAAGTGGTGAAGCCACAGA
CGGAGCCAGGCCCCAGGCCCTCCCGGAGCCCATGCAGGAGTCCAAGGCTGAGGGGAACAATCAGGCCCCTGGGGAGGAAGAGGAGGAGGA
GGAGGAGGCCACCAACACCCACCCTCCAGCCAGCCTCCCCAGCCAGAAATACCCAGGCCCACAGGCCGAGGGGGACAGTGAGGGCCTCTC
TCAGGGTCTGGTGGACAGAGAGAAGGGCCTGAGTGCAGAGCCAGGGTGGCAGGCAAAGAGAGAAGAGGAGGAGGAGGAGGAGGAGGAGGC
TGAGGCTGGAGAGGAGGCTGTCCCCGAGGAAGAAGGCCCCACTGTAGTGCTGAACCCCCACCCGAGCCTTGGCTACAAGGAGATCCGGAA
AGGCGAGAGGACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTGGAGG
CCATCCTCCCGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAGCGCA
AACCGCAGACCAGAGAGAGCGTAGCCACCACCAGGATGGCAGTGATAATGAGGAAGAAGTGAGCAAGAGATATGGGGGCTTCATGAGAGG
CTTAAAGAGAAGCCCCCAACTGGAAGATGAAGCCAAAGAGCTGCAGAAGCGATATGGGGGCTTCATGAGAAGAGTAGGTCGCCCAGAGTG
GTGGATGGACTACCAGAAACGGTATGGAGGTTTCCTGAAGCGCTTTGCCGAGGCTCTGCCCTCCGACGAAGAAGGCGAAAGTTACTCCAA

>16444_16444_3_CHGA-PENK_CHGA_chr14_93399009_ENST00000216492_PENK_chr8_57354134_ENST00000451791_length(amino acids)=314AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP
MPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA
EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE

--------------------------------------------------------------
>16444_16444_4_CHGA-PENK_CHGA_chr14_93399009_ENST00000334654_PENK_chr8_57354134_ENST00000451791_length(transcript)=1030nt_BP=726nt
CGAGCCCCGTGCAGGGGAGCTTGCGGGAGGATCGACCGACAGACGGACGCACGCCGAGGCACTGCGCCCCCAGCCCCGCGCCGGTGCCAC
CGCAGCCCGACCCCGGCCGCCAGTCCAGCCGCCCCTCGCCCGGTGCCTAGGTGCCCGGCCCCACACCGCCAGCTGCTCGGCGCCCGGGTC
CGCCATGCGCTCCGCCGCTGTCCTGGCTCTTCTGCTCTGCGCCGGGCAAGTCACTGCGCTCCCTGTGAACAGCCCTATGAATAAAGGGGA
TACCGAGGTGATGAAATGCATCGTTGAGGTCATCTCCGACACACTTTCCAAGCCCAGCCCCATGCCTGTCAGCCAGGAATGTTTTGAGAC
ACTCCGAGGAGATGAACGGATCCTTTCCATTCTGAGACATCAGAATTTACTGAAGGAGCTCCAAGACCTCGCTCTCCAAGGCGCCAAGGA
GAGGGCACATCAGCAGAAGAAACACAGCGGTTTTGAAGATGAACTCTCAGAGGTTCTTGAGAACCAGAGCAGCCAGGCCGAGCTGAAAGG
GACAGTTCCATGAAGCTCTCCTTCCGGGCCCGGGCCTACGGCTTCAGGGGCCCTGGGCCGCAGCTGCGACGAGGCTGGAGGCCATCCTCC
CGGGAGGACAGCCTTGAGGCGGGCCTGCCCCTCCAGGTCCGAGGCTACCCCGAGGAGAAGAAAGAGGAGGAGGGCAGCGCAAACCGCAGA
CCAGAGAGAGCGTAGCCACCACCAGGATGGCAGTGATAATGAGGAAGAAGTGAGCAAGAGATATGGGGGCTTCATGAGAGGCTTAAAGAG
AAGCCCCCAACTGGAAGATGAAGCCAAAGAGCTGCAGAAGCGATATGGGGGCTTCATGAGAAGAGTAGGTCGCCCAGAGTGGTGGATGGA
CTACCAGAAACGGTATGGAGGTTTCCTGAAGCGCTTTGCCGAGGCTCTGCCCTCCGACGAAGAAGGCGAAAGTTACTCCAAAGAAGTTCC

>16444_16444_4_CHGA-PENK_CHGA_chr14_93399009_ENST00000334654_PENK_chr8_57354134_ENST00000451791_length(amino acids)=163AA_BP=
MRPQPRAGATAARPRPPVQPPLARCLGARPHTASCSAPGSAMRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHGA-PENK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHGA-PENK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHGA-PENK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource