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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHID1-CORO7 (FusionGDB2 ID:16490)

Fusion Gene Summary for CHID1-CORO7

check button Fusion gene summary
Fusion gene informationFusion gene name: CHID1-CORO7
Fusion gene ID: 16490
HgeneTgene
Gene symbol

CHID1

CORO7

Gene ID

66005

100529144

Gene namechitinase domain containing 1CORO7-PAM16 readthrough
SynonymsGL008|SI-CLP|SICLPCORO7|Coronin-7|Crn7
Cytomap

11p15.5

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionchitinase domain-containing protein 1stabilin-1 interacting chitinase-like proteinCORO7-PAM16 protein70 kDa WD repeat tumor rejection antigen homolog
Modification date2020031320200313
UniProtAcc

Q9BWS9

P57737

Ensembl transtripts involved in fusion geneENST00000323578, ENST00000336845, 
ENST00000429789, ENST00000436108, 
ENST00000528581, ENST00000323541, 
ENST00000449825, ENST00000454838, 
ENST00000526714, 		ENST00000251166, 
ENST00000423908, ENST00000537233, 
ENST00000539968, ENST00000574025, 
ENST00000577144, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 4 X 4=64
# samples 44
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHID1 [Title/Abstract] AND CORO7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHID1(910775)-CORO7(4438632), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHID1

GO:1900016

negative regulation of cytokine production involved in inflammatory response

20724479


check buttonFusion gene breakpoints across CHID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CORO7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0156-01ACHID1chr11

908545

-CORO7chr16

4438635

-
ChimerDB4GBMTCGA-06-0156-01ACHID1chr11

910775

-CORO7chr16

4438632

-


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Fusion Gene ORF analysis for CHID1-CORO7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000323578ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-3CDSENST00000336845ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-3CDSENST00000336845ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-3CDSENST00000429789ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-3CDSENST00000436108ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-3CDSENST00000436108ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-3CDSENST00000528581ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000323578ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000323578ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000323578ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000323578ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000336845ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000336845ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000336845ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000336845ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000336845ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000336845ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000336845ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000336845ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000429789ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000429789ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000429789ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000429789ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000436108ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000436108ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000436108ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000436108ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000436108ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000436108ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000436108ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-5UTRENST00000436108ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000528581ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000528581ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000528581ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-5UTRENST00000528581ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-intronENST00000323578ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-intronENST00000336845ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-intronENST00000336845ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-intronENST00000429789ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-intronENST00000436108ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
5UTR-intronENST00000436108ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
5UTR-intronENST00000528581ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
intron-3CDSENST00000323541ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-3CDSENST00000323541ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
intron-3CDSENST00000323578ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-3CDSENST00000429789ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-3CDSENST00000449825ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-3CDSENST00000449825ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
intron-3CDSENST00000454838ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-3CDSENST00000454838ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
intron-3CDSENST00000526714ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-3CDSENST00000526714ENST00000251166CHID1chr11

910775

-CORO7chr16

4438632

-
intron-3CDSENST00000528581ENST00000251166CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323541ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323541ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000323541ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323541ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000323541ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323541ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000323541ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323541ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000323578ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323578ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323578ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000323578ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000429789ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000429789ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000429789ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000429789ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000449825ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000449825ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000449825ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000449825ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000449825ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000449825ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000449825ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000449825ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000454838ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000454838ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000454838ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000454838ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000454838ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000454838ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000454838ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000454838ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000526714ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000526714ENST00000423908CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000526714ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000526714ENST00000537233CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000526714ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000526714ENST00000539968CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000526714ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000526714ENST00000574025CHID1chr11

910775

-CORO7chr16

4438632

-
intron-5UTRENST00000528581ENST00000423908CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000528581ENST00000537233CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000528581ENST00000539968CHID1chr11

908545

-CORO7chr16

4438635

-
intron-5UTRENST00000528581ENST00000574025CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000323541ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000323541ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
intron-intronENST00000323578ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000429789ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000449825ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000449825ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
intron-intronENST00000454838ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000454838ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
intron-intronENST00000526714ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-
intron-intronENST00000526714ENST00000577144CHID1chr11

910775

-CORO7chr16

4438632

-
intron-intronENST00000528581ENST00000577144CHID1chr11

908545

-CORO7chr16

4438635

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHID1-CORO7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHID1-CORO7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:910775/:4438632)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHID1

Q9BWS9

CORO7

P57737

FUNCTION: Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269|PubMed:20724479}.FUNCTION: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CHID1-CORO7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHID1-CORO7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHID1-CORO7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHID1-CORO7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource