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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHKA-XRRA1 (FusionGDB2 ID:16506)

Fusion Gene Summary for CHKA-XRRA1

check button Fusion gene summary
Fusion gene informationFusion gene name: CHKA-XRRA1
Fusion gene ID: 16506
HgeneTgene
Gene symbol

CHKA

XRRA1

Gene ID

1119

143570

Gene namecholine kinase alphaX-ray radiation resistance associated 1
SynonymsCHK|CK|CKI|EK-
Cytomap

11q13.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptioncholine kinase alphaCHETK-alphaethanolamine kinaseX-ray radiation resistance-associated protein 1
Modification date2020031320200313
UniProtAcc

P35790

.
Ensembl transtripts involved in fusion geneENST00000265689, ENST00000356135, 
ENST00000533728, 
ENST00000321448, 
ENST00000527087, ENST00000533598, 
ENST00000340360, 
Fusion gene scores* DoF score12 X 7 X 5=4207 X 9 X 6=378
# samples 139
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHKA [Title/Abstract] AND XRRA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHKA(67888295)-XRRA1(74641417), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHKA

GO:0006646

phosphatidylethanolamine biosynthetic process

19915674

HgeneCHKA

GO:0006656

phosphatidylcholine biosynthetic process

19915674

TgeneXRRA1

GO:0010165

response to X-ray

12908878


check buttonFusion gene breakpoints across CHKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across XRRA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A3OD-01ACHKAchr11

67888295

-XRRA1chr11

74641417

-
ChimerDB4BRCATCGA-AC-A3OD-01BCHKAchr11

67888295

-XRRA1chr11

74641417

-


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Fusion Gene ORF analysis for CHKA-XRRA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000265689ENST00000321448CHKAchr11

67888295

-XRRA1chr11

74641417

-
5CDS-5UTRENST00000265689ENST00000527087CHKAchr11

67888295

-XRRA1chr11

74641417

-
5CDS-5UTRENST00000265689ENST00000533598CHKAchr11

67888295

-XRRA1chr11

74641417

-
5CDS-5UTRENST00000356135ENST00000321448CHKAchr11

67888295

-XRRA1chr11

74641417

-
5CDS-5UTRENST00000356135ENST00000527087CHKAchr11

67888295

-XRRA1chr11

74641417

-
5CDS-5UTRENST00000356135ENST00000533598CHKAchr11

67888295

-XRRA1chr11

74641417

-
In-frameENST00000265689ENST00000340360CHKAchr11

67888295

-XRRA1chr11

74641417

-
In-frameENST00000356135ENST00000340360CHKAchr11

67888295

-XRRA1chr11

74641417

-
intron-3CDSENST00000533728ENST00000340360CHKAchr11

67888295

-XRRA1chr11

74641417

-
intron-5UTRENST00000533728ENST00000321448CHKAchr11

67888295

-XRRA1chr11

74641417

-
intron-5UTRENST00000533728ENST00000527087CHKAchr11

67888295

-XRRA1chr11

74641417

-
intron-5UTRENST00000533728ENST00000533598CHKAchr11

67888295

-XRRA1chr11

74641417

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000265689CHKAchr1167888295-ENST00000340360XRRA1chr1174641417-53993773322428698
ENST00000356135CHKAchr1167888295-ENST00000340360XRRA1chr1174641417-56396175722668698

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265689ENST00000340360CHKAchr1167888295-XRRA1chr1174641417-0.0037191790.99628085
ENST00000356135ENST00000340360CHKAchr1167888295-XRRA1chr1174641417-0.0045933660.9954066

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Fusion Genomic Features for CHKA-XRRA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHKA-XRRA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:67888295/chr11:74641417)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHKA

P35790

.
FUNCTION: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline. {ECO:0000269|PubMed:19915674}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67888295chr11:74641417ENST00000265689-11250_85116458.0Compositional biasNote=Pro-rich
HgeneCHKAchr11:67888295chr11:74641417ENST00000356135-11150_85116440.0Compositional biasNote=Pro-rich
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216723_7450518.0Coiled coilOntology_term=ECO:0000255
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419723_745109793.0Coiled coilOntology_term=ECO:0000255
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415723_745109599.0Coiled coilOntology_term=ECO:0000255
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216104_1250518.0RepeatNote=LRR 1
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216141_1550518.0RepeatNote=LRR 2
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216164_1840518.0RepeatNote=LRR 3
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216188_2090518.0RepeatNote=LRR 4
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216229_2500518.0RepeatNote=LRR 5
TgeneXRRA1chr11:67888295chr11:74641417ENST00000321448216254_2750518.0RepeatNote=LRR 6
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419141_155109793.0RepeatNote=LRR 2
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419164_184109793.0RepeatNote=LRR 3
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419188_209109793.0RepeatNote=LRR 4
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419229_250109793.0RepeatNote=LRR 5
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419254_275109793.0RepeatNote=LRR 6
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415141_155109599.0RepeatNote=LRR 2
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415164_184109599.0RepeatNote=LRR 3
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415188_209109599.0RepeatNote=LRR 4
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415229_250109599.0RepeatNote=LRR 5
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415254_275109599.0RepeatNote=LRR 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHKAchr11:67888295chr11:74641417ENST00000265689-112117_123116458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67888295chr11:74641417ENST00000265689-112207_213116458.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67888295chr11:74641417ENST00000356135-111117_123116440.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67888295chr11:74641417ENST00000356135-111207_213116440.0Nucleotide bindingNote=ATP
HgeneCHKAchr11:67888295chr11:74641417ENST00000265689-112119_121116458.0RegionNote=Substrate binding
HgeneCHKAchr11:67888295chr11:74641417ENST00000356135-111119_121116440.0RegionNote=Substrate binding
TgeneXRRA1chr11:67888295chr11:74641417ENST00000340360419104_125109793.0RepeatNote=LRR 1
TgeneXRRA1chr11:67888295chr11:74641417ENST00000527087415104_125109599.0RepeatNote=LRR 1


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Fusion Gene Sequence for CHKA-XRRA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16506_16506_1_CHKA-XRRA1_CHKA_chr11_67888295_ENST00000265689_XRRA1_chr11_74641417_ENST00000340360_length(transcript)=5399nt_BP=377nt
CCGCGCCTCCTCGGCCGCCTGTCGGGCATGAAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGC
TGCGGTAGCGGCAGCGCGGCCCCGGCGCCCGGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAA
CAGCCGCCGCTCGCGCTGCCCCCTCCGCCGCCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAG
CAGCCGGAGCCCCGGACGCGGCGCAGGGCCTATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTC
CACATCAGTGTCATCAGGCCAAGGAAAATGACTTCAAGCATTTTCATTCTGTGATTTATATCAATGCCTCAGAAAACCTGCTGCCTCTAG
AGGCATTTCACACGTTTCCAGCCCTAAAGGAACTGGATCTCGCATTTAATGGCATCAAAACTATCTACGTGAAATATGGAGACTTTAAGT
TATTAGAATTCTTGGACCTTTCCTTCAACAGCCTGACTGTGGAGGCCATCTGTGATTTGGGGATTCTGCCACACCTCCGTGTCCTGCTCC
TCACAGGCAATGGCCTTACCTCCCTGCCGCCCAATTTGGCCGTCGCAGAACAGGAGGCATCTGTAACATCGCTGACAAGCAAGAGGTACA
TCCTGAGGTTCCCAGCGCTGGAGACACTGATGCTGGATGACAACAGACTCTCCAACCCCAGTTGCTTTGCCAGCCTGGCTGGGCTCAGGA
GACTGAAGAAGTTAAGCTTGGATGAAAACAGGATTATCAGGATCCCATACCTACAGCAAGTTCAGCTCTATGACGAGTCAGTAGACTGGA
ATGGAGGCAGGGGAAGTCCCCATAAAGAGCCCCAATTCATGCTGCAGTCCAAGCCAAGGATGCTTGAGGACTCAGATGAGCAACTGGATT
ATACTGTACTGCCCATGAAAAAGGATGTTGACCGGACAGAGGTTGTGTTTTCATCTTACCCTGGATTTTCAACCTCAGAGACAACCAAGA
TATGTTCACTTCCTCCCATATTCGAGATCCTTCCTGTGAAGTCACTGAAGGCCAGGAACCAGACGCTGGCCCCACCCTTCCCAGAGCTGA
GATACCTTAGCCTGGCCTACAACAAGATCGCAAAAGAGGATGCTGTCCTACCAGTAGCTCTCTTCCCATCTCTCTGCGAGTTCGTCTTTC
ATAACAACCCTCTGGTGGCCCATACACGAGGGGTCCCTCCACTGCTGAAGAGCTTCCTCCAGGAGCGACTGGGAATCCACTTAATTCGAA
GGAAGATAGTAAAGCCTAAGCATCATGTTTTGATGTCTCGGAAGGAATCATGGAAGGTGAAAAGCGAAATCCCAAAGGTGCCGAAGCAGC
CTCTGGTGCTCCATCACCCGCGCATGACGACAACCAAGTCTCCCTCAAAGGATATGCTAGAGCCAGAGGCAGAGCTGGCTGAAGATCTGC
CCACTACCAAAAGCACTTCTGTGGAGTCAGAGATGCCCACTGAGAACCTGGAAGGCCATTCCCCGTCTTGCCGGACCTTCGTGCCACTGC
CTCCCATCTGCTCCAACTCCACTGTGCATAGTGAAGAGACCCTGTCCCACCTGAGTGACACAACTGTCCGCCTCAGCCCAGAGCGCCCAT
CAGATGAGGACTCCAAGAGCACAGAGTCCATCTTCCTGACCCAGGTGAGTGAACTGCCTTCCTCCGTCATCCATAAGGATGATTTAGAGT
TAAAGGAGAAAGACCAAAAGAAACCACCAACGGCACCCAGAGAGGTGAAAGGGACTCGGAGGAAACTCCCAACTGCCTTCCTTCCCAGCA
AGTACCACGGCTATGAAGAACTGCTGACAGCCAAGCCTGATCCAGCCTTCATTGAGCCAAAGGGAATCCAGAAGAATGCACAAGCCCTGC
AACAAATGCTGAAGCACCCACTCCTGTGCCACTCCTCCAAGCCCAAGCTGGACACTCTTCAGAAACCCTATGTTCACAAAGAGAAACGGG
CCCAGAGAATCCCGATTCCACCCCCAAAGAAGACTAGAGCCCAACTTCTGGATGACATCTTCATTCGCTTGCGGGATCCCCGGAACATTA
CAGAGGCTCCACTAGGTGCTGTCCTGCACCAGTGGACAGAACGGCGGCTGGTGAACCACAAGCAGTACCTGGAGGCCAAGAGGCTGTTGA
AGGAGTTCCAGGCACGTTACCGGCAGCTGGTGAGTGGCTCTCTGCGCACAGTGTTCGGGACTACCCCGCTCCCCATGGCCTGCCCAGCGC
TGAGTGAGAGCCAGCCCAAGTTCGGCCACTTCCTCGAGTTCATGGATGAGTTCTGCCAGGAGCCCACAGCCAGTGACTCACAAGGCTAGA
GCTGTGCATGGGGGCTGTGTGCACCACCCGGCCTGTGCCCCAGCTCTCCCCGAGGGCTCTGTGCCCTGGACCGCACCTCAAGGTTGACCA
GCCGGCCACAGGCCTCAGAGCTCAGCTGGGCCCCACTTGCTGGCCACAAGGTGGCATCCCCTTGTCAGGATCTCCCCTCCTTGGCCCAGG
CATGACCTGGTGCCTGGCCCAGCGGCAATAAAGAGTGGGTGCACAGGGCAATAGACTGGGTGCCACATGCATTCTTTCTTGGAACCCAGG
CCACAGCAGCATTGTCACACTTCCCTCTAAAAATGGTTTTCCAGTTCAGATGCAACAGGGATACATTTGTTCTCTGTTGTATGAGAAACT
GACACCAAGGGGATCTTAACAAATTCCTGAACAATGGCTCCAAAAAAGGGTATTTTTAAAAACCAGATCTTGTGAGTACAGCCCTAATGT
GCAGGGACAGTGTCATCCTGTATATTCGTTCTTTACTCAGACTCTTTCTTGGTTCCTTCATTAGGAGCATGAATGGTTGAATGTGAACAT
GACAGTAAATTGGAGCAAACTGTAAACTGGACATAACTTATGCCAAAAGACGTAGTTGTACACCATGGAAACCCCATCCCTGCTCCTAAT
CTCTACTGCCATTCTGAATGCCAAAGCAAGACATCCAACATGGGGCATCTCCCAGAGCACATACAGCACCAAAAATCCACACACAGCCTA
AGCTTAACCCATGTTTTTGTCTGAGATTGTTCACCAGAGACAAGACTCTGACTATAAACAGAACATCCACTTTCATGAGTTTCCTTTACT
GTATTCTCAACTTGGGCCTTGCTTCAAGCAGGCAAACATACATTGAAGAATGCACTTTGGTACTGTTTAAATAACAACACATCAGCCCAC
TTGATTCCATGCCATGTCCTTGCTGACAGAAACATCCCCAACAGGGCATGCCCTGGTCCAAGTCCTCTGTCTTTGTCAAAATGCTCTTCT
GATGAGTTGGAGAGGAGGCAGCCAGCAGTGGCAGTCCACAAGGATCCAGGTACCTTCTCCAATCCTAAAGCAGACAGCAGGTTGAATAAA
ACCAATACACAACCTATTTTCTAGGCAGGAGGGGAAAAGGCCCTTAGGACAATAATATTTGTACAAAGAGTTGAGAGTAAACAAACAGTG
TATCAGGTTCAAAAAAAAAAAAACTATTCGTTGGCATTTAAATTTTTTTCCCTTGCATAGTATCTATTCTCTCACTAGGACTTTTAAGTG
CTCTGCTGGAGGCTCAGCGTTGGTAATACCATGTTTGATGCAAACTTGAACCCAATGCTCTCATTGGTGGCACAGCTTTGGAGGGTGGTG
GCCCCAAGAAGGGGCAATCTGCCTGCTGCTATATTAATCTGGAACCAGGGCCAACAGCTACTCTTGAACTATGGTATTTGAAGAGCGAGT
TCATTGCCTGTTTTACCTTAAATGACAGGAAAGGAAGATGAACAAACCTTGCTTTGCCTTGGCTTCAAACTAGTTCTTGATTTAAGACAC
CAGAAAGGGAGAGAGGGAGTCTGCTTAGAGTTTGAGGTTGCCTCTCACAAGATGACAGTTAAAAGTTGCCACCTTACTTAAAAGGCATTA
AGGAGGCATTTACTCACAAAGGAGAGAGAGTAAATTTTTTTCTTAAGAGGAAAAAAATACTGATAATACATAGAACAATCTGCACATCCA
GTCTTGGCACTTTTTCCAATTTGACTGATCTCTAAACTGGTGACCCTTGCATATATCTTAGTCTCTTTTCTACAATCTTCTTCAGAAAGC
TACAGCAGCTAACAATCATGTATAAAGATGCATTTCCTAGATCATCTTCAGAAGAAAATCTCTTCAGCACTTTCCCTAGAATCTGTCTCC
TGACCACCCCGCCCCAGACCTGCTTTCTCTTTTGAGAATTCATAACCAGGTATGTTTAGATACCAGTTCAAAAGACCACTCTATGGGTTG
ATGAGGAAAAGGCTGCCTGAGGACAATTTAAGACCATAATGAGTTTCCAATTTTTAAAGAAAATTTGGCTAGCTGGCTTTTAATTCTTAA
TTAAAATCATTAAATTTAATTAAAATTATTCCAATCAAAATATATCACTTTCCAAGATTCCACATTCATATTACTTACTTATACTATGGA
GACTTTCTCTACCTGAGCATGTATTCAGGGGCTATAGGTACATTTAACTCTAACTAACTGAAAAAAATCAGGAAGAAAAAACTATTAAAA
TAAAATAACCTCCTAAATCATTTGGGGGTATCCCCATCATTGGTGCGTGTGTCTGCGTGTGTCAAACTTTAATGATTATTTATTCAGACC
CTGGAAAACCACACTATAAAATAGGGCACTGGATCACAAGTTCGTTTGGTTAAAAAAAAAAAAAAAAAAAAGTGGGGGCGGGGGGCAGAG
AAGAAGTTTAACTTGGATGATTTCCATGCCCATTCCAGCTGTAACATTCTATGACTGTGACCCAGCCTTTGTTCTCTTTTCTCACTCTCC
TACTAGACATTTCAATGAAAAGTTAGGCAGGAAAAAGGAAAGGAATCCCAAGTTGCTGCCAGCTCTGATGAGAGATCAGGTTGGGGGAGA
GATTAGGTGGTTACTGAATTGAGGTGTGGGCCTCCCCTGACCATGTCAGTGATCCACAACCCACCTCACTTCTTGGGGCTTAAGCTAAAA
GCAGCTTCTGAAGAGATGTTAATGTCCTGTAATCACTAGAGGAGAAAATTCATTCTCCTTCCATAACATTACTTAGTAAAGGAAAAGCGG
TGGTGCAATCAAATTCACAAATACCAATGGGGTCTCTAAAATGTAGAATGCAGCTTGCTGGGTGCTGGTCAGTTTTCTAAATGGGACCAG

>16506_16506_1_CHKA-XRRA1_CHKA_chr11_67888295_ENST00000265689_XRRA1_chr11_74641417_ENST00000340360_length(amino acids)=698AA_BP=14
MAGPPRGRVPHQCHQAKENDFKHFHSVIYINASENLLPLEAFHTFPALKELDLAFNGIKTIYVKYGDFKLLEFLDLSFNSLTVEAICDLG
ILPHLRVLLLTGNGLTSLPPNLAVAEQEASVTSLTSKRYILRFPALETLMLDDNRLSNPSCFASLAGLRRLKKLSLDENRIIRIPYLQQV
QLYDESVDWNGGRGSPHKEPQFMLQSKPRMLEDSDEQLDYTVLPMKKDVDRTEVVFSSYPGFSTSETTKICSLPPIFEILPVKSLKARNQ
TLAPPFPELRYLSLAYNKIAKEDAVLPVALFPSLCEFVFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKPKHHVLMSRKESWKVK
SEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDT
TVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPK
GIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHK

--------------------------------------------------------------
>16506_16506_2_CHKA-XRRA1_CHKA_chr11_67888295_ENST00000356135_XRRA1_chr11_74641417_ENST00000340360_length(transcript)=5639nt_BP=617nt
GTGGCGAGCGCGAGGGCGGGCTGTGACGCGGCCGGCGCTCCTCGTGCGGCGGCGGCAGAGGAGCGAGTGCAGCGGCCAGCAGCACATCCC
CGCTCCACAGTCGCCGCAGTCGCCGCAGCCGCCGCCGCCGCCCCGCGCGCCCAACCGCCGCGGCCCCCTGCCCCGCCGGCCTGCCAGTGA
GAGAGCGGCGAGGGGGCGCCCGGCCGGACTCTGAGCCTAGTCCTCTCGCGCTGCGGCCGCCCGCGCCTCCTCGGCCGCCTGTCGGGCATG
AAAACCAAATTCTGCACCGGGGGCGAGGCGGAGCCCTCGCCGCTCGGGCTGCTGCTGAGCTGCGGTAGCGGCAGCGCGGCCCCGGCGCCC
GGCGTGGGGCAGCAGCGCGACGCCGCCAGCGACCTCGAGTCCAAGCAGCTGGGCGGCCAACAGCCGCCGCTCGCGCTGCCCCCTCCGCCG
CCGCTGCCGCTGCCGCTGCCGCTGCCCCAGCCCCCGCCGCCGCAGCCGCCCGCAGACGAGCAGCCGGAGCCCCGGACGCGGCGCAGGGCC
TATCTGTGGTGCAAGGAGTTCCTGCCCGGCGCCTGGCGGGGCCTCCGCGAGGACGAGTTCCACATCAGTGTCATCAGGCCAAGGAAAATG
ACTTCAAGCATTTTCATTCTGTGATTTATATCAATGCCTCAGAAAACCTGCTGCCTCTAGAGGCATTTCACACGTTTCCAGCCCTAAAGG
AACTGGATCTCGCATTTAATGGCATCAAAACTATCTACGTGAAATATGGAGACTTTAAGTTATTAGAATTCTTGGACCTTTCCTTCAACA
GCCTGACTGTGGAGGCCATCTGTGATTTGGGGATTCTGCCACACCTCCGTGTCCTGCTCCTCACAGGCAATGGCCTTACCTCCCTGCCGC
CCAATTTGGCCGTCGCAGAACAGGAGGCATCTGTAACATCGCTGACAAGCAAGAGGTACATCCTGAGGTTCCCAGCGCTGGAGACACTGA
TGCTGGATGACAACAGACTCTCCAACCCCAGTTGCTTTGCCAGCCTGGCTGGGCTCAGGAGACTGAAGAAGTTAAGCTTGGATGAAAACA
GGATTATCAGGATCCCATACCTACAGCAAGTTCAGCTCTATGACGAGTCAGTAGACTGGAATGGAGGCAGGGGAAGTCCCCATAAAGAGC
CCCAATTCATGCTGCAGTCCAAGCCAAGGATGCTTGAGGACTCAGATGAGCAACTGGATTATACTGTACTGCCCATGAAAAAGGATGTTG
ACCGGACAGAGGTTGTGTTTTCATCTTACCCTGGATTTTCAACCTCAGAGACAACCAAGATATGTTCACTTCCTCCCATATTCGAGATCC
TTCCTGTGAAGTCACTGAAGGCCAGGAACCAGACGCTGGCCCCACCCTTCCCAGAGCTGAGATACCTTAGCCTGGCCTACAACAAGATCG
CAAAAGAGGATGCTGTCCTACCAGTAGCTCTCTTCCCATCTCTCTGCGAGTTCGTCTTTCATAACAACCCTCTGGTGGCCCATACACGAG
GGGTCCCTCCACTGCTGAAGAGCTTCCTCCAGGAGCGACTGGGAATCCACTTAATTCGAAGGAAGATAGTAAAGCCTAAGCATCATGTTT
TGATGTCTCGGAAGGAATCATGGAAGGTGAAAAGCGAAATCCCAAAGGTGCCGAAGCAGCCTCTGGTGCTCCATCACCCGCGCATGACGA
CAACCAAGTCTCCCTCAAAGGATATGCTAGAGCCAGAGGCAGAGCTGGCTGAAGATCTGCCCACTACCAAAAGCACTTCTGTGGAGTCAG
AGATGCCCACTGAGAACCTGGAAGGCCATTCCCCGTCTTGCCGGACCTTCGTGCCACTGCCTCCCATCTGCTCCAACTCCACTGTGCATA
GTGAAGAGACCCTGTCCCACCTGAGTGACACAACTGTCCGCCTCAGCCCAGAGCGCCCATCAGATGAGGACTCCAAGAGCACAGAGTCCA
TCTTCCTGACCCAGGTGAGTGAACTGCCTTCCTCCGTCATCCATAAGGATGATTTAGAGTTAAAGGAGAAAGACCAAAAGAAACCACCAA
CGGCACCCAGAGAGGTGAAAGGGACTCGGAGGAAACTCCCAACTGCCTTCCTTCCCAGCAAGTACCACGGCTATGAAGAACTGCTGACAG
CCAAGCCTGATCCAGCCTTCATTGAGCCAAAGGGAATCCAGAAGAATGCACAAGCCCTGCAACAAATGCTGAAGCACCCACTCCTGTGCC
ACTCCTCCAAGCCCAAGCTGGACACTCTTCAGAAACCCTATGTTCACAAAGAGAAACGGGCCCAGAGAATCCCGATTCCACCCCCAAAGA
AGACTAGAGCCCAACTTCTGGATGACATCTTCATTCGCTTGCGGGATCCCCGGAACATTACAGAGGCTCCACTAGGTGCTGTCCTGCACC
AGTGGACAGAACGGCGGCTGGTGAACCACAAGCAGTACCTGGAGGCCAAGAGGCTGTTGAAGGAGTTCCAGGCACGTTACCGGCAGCTGG
TGAGTGGCTCTCTGCGCACAGTGTTCGGGACTACCCCGCTCCCCATGGCCTGCCCAGCGCTGAGTGAGAGCCAGCCCAAGTTCGGCCACT
TCCTCGAGTTCATGGATGAGTTCTGCCAGGAGCCCACAGCCAGTGACTCACAAGGCTAGAGCTGTGCATGGGGGCTGTGTGCACCACCCG
GCCTGTGCCCCAGCTCTCCCCGAGGGCTCTGTGCCCTGGACCGCACCTCAAGGTTGACCAGCCGGCCACAGGCCTCAGAGCTCAGCTGGG
CCCCACTTGCTGGCCACAAGGTGGCATCCCCTTGTCAGGATCTCCCCTCCTTGGCCCAGGCATGACCTGGTGCCTGGCCCAGCGGCAATA
AAGAGTGGGTGCACAGGGCAATAGACTGGGTGCCACATGCATTCTTTCTTGGAACCCAGGCCACAGCAGCATTGTCACACTTCCCTCTAA
AAATGGTTTTCCAGTTCAGATGCAACAGGGATACATTTGTTCTCTGTTGTATGAGAAACTGACACCAAGGGGATCTTAACAAATTCCTGA
ACAATGGCTCCAAAAAAGGGTATTTTTAAAAACCAGATCTTGTGAGTACAGCCCTAATGTGCAGGGACAGTGTCATCCTGTATATTCGTT
CTTTACTCAGACTCTTTCTTGGTTCCTTCATTAGGAGCATGAATGGTTGAATGTGAACATGACAGTAAATTGGAGCAAACTGTAAACTGG
ACATAACTTATGCCAAAAGACGTAGTTGTACACCATGGAAACCCCATCCCTGCTCCTAATCTCTACTGCCATTCTGAATGCCAAAGCAAG
ACATCCAACATGGGGCATCTCCCAGAGCACATACAGCACCAAAAATCCACACACAGCCTAAGCTTAACCCATGTTTTTGTCTGAGATTGT
TCACCAGAGACAAGACTCTGACTATAAACAGAACATCCACTTTCATGAGTTTCCTTTACTGTATTCTCAACTTGGGCCTTGCTTCAAGCA
GGCAAACATACATTGAAGAATGCACTTTGGTACTGTTTAAATAACAACACATCAGCCCACTTGATTCCATGCCATGTCCTTGCTGACAGA
AACATCCCCAACAGGGCATGCCCTGGTCCAAGTCCTCTGTCTTTGTCAAAATGCTCTTCTGATGAGTTGGAGAGGAGGCAGCCAGCAGTG
GCAGTCCACAAGGATCCAGGTACCTTCTCCAATCCTAAAGCAGACAGCAGGTTGAATAAAACCAATACACAACCTATTTTCTAGGCAGGA
GGGGAAAAGGCCCTTAGGACAATAATATTTGTACAAAGAGTTGAGAGTAAACAAACAGTGTATCAGGTTCAAAAAAAAAAAAACTATTCG
TTGGCATTTAAATTTTTTTCCCTTGCATAGTATCTATTCTCTCACTAGGACTTTTAAGTGCTCTGCTGGAGGCTCAGCGTTGGTAATACC
ATGTTTGATGCAAACTTGAACCCAATGCTCTCATTGGTGGCACAGCTTTGGAGGGTGGTGGCCCCAAGAAGGGGCAATCTGCCTGCTGCT
ATATTAATCTGGAACCAGGGCCAACAGCTACTCTTGAACTATGGTATTTGAAGAGCGAGTTCATTGCCTGTTTTACCTTAAATGACAGGA
AAGGAAGATGAACAAACCTTGCTTTGCCTTGGCTTCAAACTAGTTCTTGATTTAAGACACCAGAAAGGGAGAGAGGGAGTCTGCTTAGAG
TTTGAGGTTGCCTCTCACAAGATGACAGTTAAAAGTTGCCACCTTACTTAAAAGGCATTAAGGAGGCATTTACTCACAAAGGAGAGAGAG
TAAATTTTTTTCTTAAGAGGAAAAAAATACTGATAATACATAGAACAATCTGCACATCCAGTCTTGGCACTTTTTCCAATTTGACTGATC
TCTAAACTGGTGACCCTTGCATATATCTTAGTCTCTTTTCTACAATCTTCTTCAGAAAGCTACAGCAGCTAACAATCATGTATAAAGATG
CATTTCCTAGATCATCTTCAGAAGAAAATCTCTTCAGCACTTTCCCTAGAATCTGTCTCCTGACCACCCCGCCCCAGACCTGCTTTCTCT
TTTGAGAATTCATAACCAGGTATGTTTAGATACCAGTTCAAAAGACCACTCTATGGGTTGATGAGGAAAAGGCTGCCTGAGGACAATTTA
AGACCATAATGAGTTTCCAATTTTTAAAGAAAATTTGGCTAGCTGGCTTTTAATTCTTAATTAAAATCATTAAATTTAATTAAAATTATT
CCAATCAAAATATATCACTTTCCAAGATTCCACATTCATATTACTTACTTATACTATGGAGACTTTCTCTACCTGAGCATGTATTCAGGG
GCTATAGGTACATTTAACTCTAACTAACTGAAAAAAATCAGGAAGAAAAAACTATTAAAATAAAATAACCTCCTAAATCATTTGGGGGTA
TCCCCATCATTGGTGCGTGTGTCTGCGTGTGTCAAACTTTAATGATTATTTATTCAGACCCTGGAAAACCACACTATAAAATAGGGCACT
GGATCACAAGTTCGTTTGGTTAAAAAAAAAAAAAAAAAAAAGTGGGGGCGGGGGGCAGAGAAGAAGTTTAACTTGGATGATTTCCATGCC
CATTCCAGCTGTAACATTCTATGACTGTGACCCAGCCTTTGTTCTCTTTTCTCACTCTCCTACTAGACATTTCAATGAAAAGTTAGGCAG
GAAAAAGGAAAGGAATCCCAAGTTGCTGCCAGCTCTGATGAGAGATCAGGTTGGGGGAGAGATTAGGTGGTTACTGAATTGAGGTGTGGG
CCTCCCCTGACCATGTCAGTGATCCACAACCCACCTCACTTCTTGGGGCTTAAGCTAAAAGCAGCTTCTGAAGAGATGTTAATGTCCTGT
AATCACTAGAGGAGAAAATTCATTCTCCTTCCATAACATTACTTAGTAAAGGAAAAGCGGTGGTGCAATCAAATTCACAAATACCAATGG
GGTCTCTAAAATGTAGAATGCAGCTTGCTGGGTGCTGGTCAGTTTTCTAAATGGGACCAGAAATGGCTTTCCTAAGACCATAAATGAACT

>16506_16506_2_CHKA-XRRA1_CHKA_chr11_67888295_ENST00000356135_XRRA1_chr11_74641417_ENST00000340360_length(amino acids)=698AA_BP=14
MAGPPRGRVPHQCHQAKENDFKHFHSVIYINASENLLPLEAFHTFPALKELDLAFNGIKTIYVKYGDFKLLEFLDLSFNSLTVEAICDLG
ILPHLRVLLLTGNGLTSLPPNLAVAEQEASVTSLTSKRYILRFPALETLMLDDNRLSNPSCFASLAGLRRLKKLSLDENRIIRIPYLQQV
QLYDESVDWNGGRGSPHKEPQFMLQSKPRMLEDSDEQLDYTVLPMKKDVDRTEVVFSSYPGFSTSETTKICSLPPIFEILPVKSLKARNQ
TLAPPFPELRYLSLAYNKIAKEDAVLPVALFPSLCEFVFHNNPLVAHTRGVPPLLKSFLQERLGIHLIRRKIVKPKHHVLMSRKESWKVK
SEIPKVPKQPLVLHHPRMTTTKSPSKDMLEPEAELAEDLPTTKSTSVESEMPTENLEGHSPSCRTFVPLPPICSNSTVHSEETLSHLSDT
TVRLSPERPSDEDSKSTESIFLTQVSELPSSVIHKDDLELKEKDQKKPPTAPREVKGTRRKLPTAFLPSKYHGYEELLTAKPDPAFIEPK
GIQKNAQALQQMLKHPLLCHSSKPKLDTLQKPYVHKEKRAQRIPIPPPKKTRAQLLDDIFIRLRDPRNITEAPLGAVLHQWTERRLVNHK

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Fusion Gene PPI Analysis for CHKA-XRRA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHKA-XRRA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHKA-XRRA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource