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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHM-CHM (FusionGDB2 ID:16515)

Fusion Gene Summary for CHM-CHM

check button Fusion gene summary
Fusion gene informationFusion gene name: CHM-CHM
Fusion gene ID: 16515
HgeneTgene
Gene symbol

CHM

CHM

Gene ID

4359

4359

Gene namemyelin protein zeromyelin protein zero
SynonymsCHM|CHN2|CMT1|CMT1B|CMT2I|CMT2J|CMT4E|CMTDI3|CMTDID|DSS|HMSNIB|MPP|P0CHM|CHN2|CMT1|CMT1B|CMT2I|CMT2J|CMT4E|CMTDI3|CMTDID|DSS|HMSNIB|MPP|P0
Cytomap

1q23.3

1q23.3

Type of geneprotein-codingprotein-coding
Descriptionmyelin protein P0Charcot-Marie-Tooth neuropathy 1Bmyelin peripheral proteinmyelin protein P0Charcot-Marie-Tooth neuropathy 1Bmyelin peripheral protein
Modification date2020032820200328
UniProtAcc

P24386

Q8WUX9

Ensembl transtripts involved in fusion geneENST00000357749, ENST00000358786, 
ENST00000467744, ENST00000537751, 
ENST00000357749, ENST00000467744, 
ENST00000358786, ENST00000537751, 
Fusion gene scores* DoF score7 X 8 X 4=2241 X 2 X 1=2
# samples 82
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: CHM [Title/Abstract] AND CHM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHM(85116796)-CHM(85116744), # samples:1
CHM(85218712)-CHM(85212958), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CHM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE814491CHMchrX

85116796

+CHMchrX

85116744

-
ChiTaRS5.0N/AM83773CHMchrX

85218712

+CHMchrX

85212958

-


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Fusion Gene ORF analysis for CHM-CHM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000357749ENST00000357749CHMchrX

85218712

+CHMchrX

85212958

-
intron-3CDSENST00000358786ENST00000357749CHMchrX

85218712

+CHMchrX

85212958

-
intron-3CDSENST00000467744ENST00000357749CHMchrX

85218712

+CHMchrX

85212958

-
intron-3CDSENST00000537751ENST00000357749CHMchrX

85218712

+CHMchrX

85212958

-
intron-3UTRENST00000357749ENST00000357749CHMchrX

85116796

+CHMchrX

85116744

-
intron-3UTRENST00000358786ENST00000357749CHMchrX

85116796

+CHMchrX

85116744

-
intron-3UTRENST00000467744ENST00000357749CHMchrX

85116796

+CHMchrX

85116744

-
intron-3UTRENST00000537751ENST00000357749CHMchrX

85116796

+CHMchrX

85116744

-
intron-5UTRENST00000357749ENST00000467744CHMchrX

85116796

+CHMchrX

85116744

-
intron-5UTRENST00000358786ENST00000467744CHMchrX

85116796

+CHMchrX

85116744

-
intron-5UTRENST00000467744ENST00000467744CHMchrX

85116796

+CHMchrX

85116744

-
intron-5UTRENST00000537751ENST00000467744CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000357749ENST00000358786CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000357749ENST00000358786CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000357749ENST00000467744CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000357749ENST00000537751CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000357749ENST00000537751CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000358786ENST00000358786CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000358786ENST00000358786CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000358786ENST00000467744CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000358786ENST00000537751CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000358786ENST00000537751CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000467744ENST00000358786CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000467744ENST00000358786CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000467744ENST00000467744CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000467744ENST00000537751CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000467744ENST00000537751CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000537751ENST00000358786CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000537751ENST00000358786CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000537751ENST00000467744CHMchrX

85218712

+CHMchrX

85212958

-
intron-intronENST00000537751ENST00000537751CHMchrX

85116796

+CHMchrX

85116744

-
intron-intronENST00000537751ENST00000537751CHMchrX

85218712

+CHMchrX

85212958

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CHM-CHM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHM-CHM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:85116796/:85116744)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHM

P24386

CHM

Q8WUX9

FUNCTION: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269|PubMed:18532927, ECO:0000269|PubMed:7957092}.FUNCTION: ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878). {ECO:0000269|PubMed:16856878, ECO:0000269|PubMed:26040712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CHM-CHM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CHM-CHM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHM-CHM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHM-CHM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource