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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHM-KLHL4 (FusionGDB2 ID:16519)

Fusion Gene Summary for CHM-KLHL4

Fusion gene summary

Fusion gene information	Fusion gene name: CHM-KLHL4
	Fusion gene ID: 16519
		Hgene	Tgene
	Gene symbol	CHM	KLHL4
	Gene ID	4359	56062
	Gene name	myelin protein zero	kelch like family member 4
	Synonyms	CHM\|CHN2\|CMT1\|CMT1B\|CMT2I\|CMT2J\|CMT4E\|CMTDI3\|CMTDID\|DSS\|HMSNIB\|MPP\|P0	DKELCHL\|KHL4
	Cytomap	1q23.3	Xq21.31
	Type of gene	protein-coding	protein-coding
	Description	myelin protein P0Charcot-Marie-Tooth neuropathy 1Bmyelin peripheral protein	kelch-like protein 4
	Modification date	20200328	20200313
	UniProtAcc	P24386	Q9P2K6
	Ensembl transtripts involved in fusion gene	ENST00000467744, ENST00000357749, ENST00000358786, ENST00000537751,	ENST00000373114, ENST00000373119,
Fusion gene scores	* DoF score	7 X 8 X 4=224	1 X 1 X 1=1
	# samples	8	1
	** MAII score	log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: CHM [Title/Abstract] AND KLHL4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHM(85282495)-KLHL4(86868880), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CHM (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KLHL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CR-7367-01A	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+

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Fusion Gene ORF analysis for CHM-KLHL4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000467744	ENST00000373114	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
5UTR-3CDS	ENST00000467744	ENST00000373119	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
In-frame	ENST00000357749	ENST00000373114	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
In-frame	ENST00000357749	ENST00000373119	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
In-frame	ENST00000358786	ENST00000373114	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
In-frame	ENST00000358786	ENST00000373119	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
intron-3CDS	ENST00000537751	ENST00000373114	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+
intron-3CDS	ENST00000537751	ENST00000373119	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000357749	CHM	chrX	85282495	-	ENST00000373119	KLHL4	chrX	86868880	+	5397	146	30	1880	616
ENST00000357749	CHM	chrX	85282495	-	ENST00000373114	KLHL4	chrX	86868880	+	2089	146	30	1886	618
ENST00000358786	CHM	chrX	85282495	-	ENST00000373119	KLHL4	chrX	86868880	+	5374	123	7	1857	616
ENST00000358786	CHM	chrX	85282495	-	ENST00000373114	KLHL4	chrX	86868880	+	2066	123	7	1863	618

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357749	ENST00000373119	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+	0.000175587	0.99982446
ENST00000357749	ENST00000373114	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+	0.000937753	0.99906224
ENST00000358786	ENST00000373119	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+	0.000179052	0.999821
ENST00000358786	ENST00000373114	CHM	chrX	85282495	-	KLHL4	chrX	86868880	+	0.001030633	0.99896944

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Fusion Genomic Features for CHM-KLHL4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CHM	chrX	85282494	-	KLHL4	chrX	86868879	+	2.08E-06	0.999998
CHM	chrX	85282494	-	KLHL4	chrX	86868879	+	2.08E-06	0.999998

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHM-KLHL4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:85282495/chrX:86868880)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHM P24386	KLHL4 Q9P2K6
FUNCTION: Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. {ECO:0000269\|PubMed:18532927, ECO:0000269\|PubMed:7957092}.	FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis. {ECO:0000269\|PubMed:19261606}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

182_249

140

721.0

Domain

BTB

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

182_249

140

719.0

Domain

BTB

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

430_476

140

721.0

Repeat

Note=Kelch 1

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

477_523

140

721.0

Repeat

Note=Kelch 2

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

525_570

140

721.0

Repeat

Note=Kelch 3

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

571_617

140

721.0

Repeat

Note=Kelch 4

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

619_670

140

721.0

Repeat

Note=Kelch 5

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373114

671_717

140

721.0

Repeat

Note=Kelch 6

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

430_476

140

719.0

Repeat

Note=Kelch 1

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

477_523

140

719.0

Repeat

Note=Kelch 2

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

525_570

140

719.0

Repeat

Note=Kelch 3

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

571_617

140

719.0

Repeat

Note=Kelch 4

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

619_670

140

719.0

Repeat

Note=Kelch 5

Tgene

KLHL4

chrX:85282495

chrX:86868880

ENST00000373119

671_717

140

719.0

Repeat

Note=Kelch 6

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CHM-KLHL4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16519_16519_1_CHM-KLHL4_CHM_chrX_85282495_ENST00000357749_KLHL4_chrX_86868880_ENST00000373114_length(transcript)=2089nt_BP=146nt
TAATAGTCACATGACACGTTTCCCGTCAAGATGGCGGATACTCTCCCTTCGGAGTTTGATGTGATCGTAATAGGGACGGGTTTGCCTGAA
TCCATCATTGCAGCTGCATGTTCAAGAAGTGGCCGGAGAGTTCTGCATGTTGATTCATTAGATACACAACACTCTGAAGACATGAATGCC
ACCAGATCTGAAGAGCAGTTCCATGTTATAAACCACGCAGAGCAAACTCTTCGTAAAATGGAGAACTACTTGAAAGAGAAACAACTATGT
GATGTGCTACTGATTGCAGGACACCTCCGCATCCCAGCCCATAGGTTGGTTCTCAGCGCAGTGTCTGATTATTTTGCTGCAATGTTTACT
AATGATGTGCTTGAAGCCAAACAAGAAGAGGTCAGGATGGAAGGAGTAGATCCAAATGCACTAAATTCCTTGGTGCAGTATGCTTACACA
GGAGTCCTGCAATTGAAAGAAGATACCATTGAAAGTTTGCTGGCTGCAGCTTGTCTTCTGCAGCTGACTCAGGTCATTGATGTTTGCTCC
AATTTTCTCATAAAGCAGCTCCATCCTTCAAACTGCTTAGGGATTCGATCATTTGGAGATGCCCAAGGCTGTACAGAACTTCTGAACGTG
GCACACAAATACACTATGGAACACTTCATTGAGGTAATAAAAAACCAAGAATTCCTCCTGCTTCCAGCTAATGAAATTTCAAAACTTCTG
TGCAGTGATGACATTAATGTGCCTGATGAAGAGACCATTTTTCATGCTCTAATGCAGTGGGTGGGGCATGATGTGCAGAATAGGCAAGGA
GAACTGGGGATGCTGCTTTCTTACATCAGACTGCCATTACTCCCACCACAGTTACTGGCAGATCTTGAAACCAGTTCCATGTTTACTGGT
GATCTTGAGTGTCAGAAGCTCCTGATGGAAGCTATGAAGTATCATCTTTTGCCTGAGAGAAGATCCATGATGCAAAGCCCTCGGACAAAG
CCTAGAAAATCAACTGTGGGGGCACTTTATGCTGTAGGAGGCATGGATGCTATGAAAGGTACTACTACTATTGAAAAATATGACCTCAGG
ACCAACAGTTGGCTACATATTGGCACCATGAATGGCCGTAGGCTTCAATTTGGAGTCGCAGTTATTGATAATAAGCTCTATGTCGTGGGA
GGAAGAGACGGTTTAAAAACTTTGAATACAGTGGAATGTTTTAATCCAGTTGGCAAAATCTGGACTGTGATGCCTCCCATGTCAACACAT
CGGCACGGCTTAGGTGTAGCCACTCTTGAAGGACCAATGTATGCTGTAGGTGGTCATGATGGATGGAGCTATCTAAATACTGTAGAAAGA
TGGGACCCTGAGGGACGACAGTGGAATTACGTAGCCAGTATGTCAACTCCTAGAAGCACAGTTGGTGTTGTTGCATTAAACAACAAATTA
TATGCTATTGGTGGACGTGATGGAAGTTCCTGCCTCAAATCAATGGAATACTTTGACCCACACACTAACAAGTGGAGTTTGTGTGCTCCA
ATGTCCAAAAGACGTGGAGGTGTGGGAGTTGCCACATACAATGGATTCTTATATGTTGTAGGGGGGCATGATGCCCCTGCTTCCAACCAT
TGCTCCAGGCTTTCTGACTGTGTGGAACGGTATGATCCAAAAGGTGATTCATGGTCAACTGTGGCACCTCTGAGTGTTCCTCGAGATGCT
GTTGCTGTGTGCCCTCTTGGAGACAAACTCTACGTGGTTGGAGGATATGACGGACATACTTATTTGAACACAGTTGAGTCATATGATGCA
CAGAGAAATGAATGGAAAGAGAGCATGCAAGAACTTCTACAAAACTTCTATACCACACAGAAGCTGAAAGAGACTCTGGGGCACTAAATT
CAGATCCTTTCTCCACACAGCAATGACATTTATCAATCTGACTCAGGTGTGGCTGTTGCCCCTTTTTGATATGGAGGGAACACTGAAAGA
CAGTTTCCTTCTGGAGTTCCAAATGCAATATAGAAAAAAAAACCCTGTGACTCTGGATTTTATTTTAAGTTCTCTAACAAGACTCCTACC

>16519_16519_1_CHM-KLHL4_CHM_chrX_85282495_ENST00000357749_KLHL4_chrX_86868880_ENST00000373114_length(amino acids)=618AA_BP=39
MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLR
IPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS
NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIR
LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTM
NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNY
VASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER

--------------------------------------------------------------
>16519_16519_2_CHM-KLHL4_CHM_chrX_85282495_ENST00000357749_KLHL4_chrX_86868880_ENST00000373119_length(transcript)=5397nt_BP=146nt
TAATAGTCACATGACACGTTTCCCGTCAAGATGGCGGATACTCTCCCTTCGGAGTTTGATGTGATCGTAATAGGGACGGGTTTGCCTGAA
TCCATCATTGCAGCTGCATGTTCAAGAAGTGGCCGGAGAGTTCTGCATGTTGATTCATTAGATACACAACACTCTGAAGACATGAATGCC
ACCAGATCTGAAGAGCAGTTCCATGTTATAAACCACGCAGAGCAAACTCTTCGTAAAATGGAGAACTACTTGAAAGAGAAACAACTATGT
GATGTGCTACTGATTGCAGGACACCTCCGCATCCCAGCCCATAGGTTGGTTCTCAGCGCAGTGTCTGATTATTTTGCTGCAATGTTTACT
AATGATGTGCTTGAAGCCAAACAAGAAGAGGTCAGGATGGAAGGAGTAGATCCAAATGCACTAAATTCCTTGGTGCAGTATGCTTACACA
GGAGTCCTGCAATTGAAAGAAGATACCATTGAAAGTTTGCTGGCTGCAGCTTGTCTTCTGCAGCTGACTCAGGTCATTGATGTTTGCTCC
AATTTTCTCATAAAGCAGCTCCATCCTTCAAACTGCTTAGGGATTCGATCATTTGGAGATGCCCAAGGCTGTACAGAACTTCTGAACGTG
GCACACAAATACACTATGGAACACTTCATTGAGGTAATAAAAAACCAAGAATTCCTCCTGCTTCCAGCTAATGAAATTTCAAAACTTCTG
TGCAGTGATGACATTAATGTGCCTGATGAAGAGACCATTTTTCATGCTCTAATGCAGTGGGTGGGGCATGATGTGCAGAATAGGCAAGGA
GAACTGGGGATGCTGCTTTCTTACATCAGACTGCCATTACTCCCACCACAGTTACTGGCAGATCTTGAAACCAGTTCCATGTTTACTGGT
GATCTTGAGTGTCAGAAGCTCCTGATGGAAGCTATGAAGTATCATCTTTTGCCTGAGAGAAGATCCATGATGCAAAGCCCTCGGACAAAG
CCTAGAAAATCAACTGTGGGGGCACTTTATGCTGTAGGAGGCATGGATGCTATGAAAGGTACTACTACTATTGAAAAATATGACCTCAGG
ACCAACAGTTGGCTACATATTGGCACCATGAATGGCCGTAGGCTTCAATTTGGAGTCGCAGTTATTGATAATAAGCTCTATGTCGTGGGA
GGAAGAGACGGTTTAAAAACTTTGAATACAGTGGAATGTTTTAATCCAGTTGGCAAAATCTGGACTGTGATGCCTCCCATGTCAACACAT
CGGCACGGCTTAGGTGTAGCCACTCTTGAAGGACCAATGTATGCTGTAGGTGGTCATGATGGATGGAGCTATCTAAATACTGTAGAAAGA
TGGGACCCTGAGGGACGACAGTGGAATTACGTAGCCAGTATGTCAACTCCTAGAAGCACAGTTGGTGTTGTTGCATTAAACAACAAATTA
TATGCTATTGGTGGACGTGATGGAAGTTCCTGCCTCAAATCAATGGAATACTTTGACCCACACACTAACAAGTGGAGTTTGTGTGCTCCA
ATGTCCAAAAGACGTGGAGGTGTGGGAGTTGCCACATACAATGGATTCTTATATGTTGTAGGGGGGCATGATGCCCCTGCTTCCAACCAT
TGCTCCAGGCTTTCTGACTGTGTGGAACGGTATGATCCAAAAGGTGATTCATGGTCAACTGTGGCACCTCTGAGTGTTCCTCGAGATGCT
GTTGCTGTGTGCCCTCTTGGAGACAAACTCTACGTGGTTGGAGGATATGACGGACATACTTATTTGAACACAGTTGAGTCATATGATGCA
CAGAGAAATGAATGGAAAGAGGAAGTTCCTGTTAACATTGGAAGAGCTGGTGCATGTGTTGTAGTGGTGAAGCTACCCTAAAGCTATCTA
TCTTTATCAAATGGAATGAAACTAGATAATTTCAAGAAACTGAGTAGGACAAAGGGAGAAAGAAATACATGTTCTTTTTCCTGCAATTAA
TAATCAGACTGGAAAATTGTTGTATCATTTTAATTTGTAGTTACAATTGCTTTCATTCGTGAAGCCGAAACGTTTTTAAACATGAATTAC
ATATGAATTATTAAGCATATGTGCTTTCGCAGCTGATAATATAAAAGGAAATCCCACAGTCTAGATATAGCCCCATTACTACAAAATGCT
AAAATATTTAATGAAAATTGATGGTGGCCACAGTGTGCAGGTTATAAAAGCATTAATACATTTCAAGGTAAGAGCCTTAAAAGTTAAAAA
CATTTTCAGTTTTTTTTTAAAAAACGTACTCTTATTATCTGGAACATAGAAATATAAAAGGTAACATCTAAAGCTTAGAATAGTGTGATT
TTTAGTAAGCCATTATTCTCCTATTCAAATAATATCCCAAAGAGCTAAACAATTCCTTACATTTACCAAGAGGAAAGCTTTTACTGTGTT
GAAGCTAAAAAAATAATGGCTCTTTGACAAAACTTGTTATGTTGATCGCGGTATGTCAAAATTTTTACAGGTTTGCTCATCTGCCAGAGC
ACACATATAAATTTGGTATTTCTTAACATATTATCTTGTTAGATTTGTTACCAGTAAAATATTACTGTAATTTCATATACACAGTCTATA
CAATGAAATAATGAATATTTATCATATTGATACAAACTGTGACCTCAGCTTCAGAGTGTCAGGGCCTCACTTGTATAGAATGTAATGTTC
TCCTCAAACATTTATGTTAACTCTATAAACAAATATCGTTAAGTTAAACAAGTTTTCAAAAACAAAACAATTTTTAAAGTACCTTAAAAT
TGAGGATGTTACTCAGTGTTAACACATGGGAACACCAAAATATTCAATAAGCCTGGTCAATTCTATAGTTATCTTTTTTGTACCAACACA
TGCTTTTCTGTTACTGTTATATTATCCAGTAGAAAATGTTAGGATATGTGTGCTATATAAAAAAAAAAAAAGACTTGTTAAGTTTTAAAA
TAACAAAAATGGCTAGTTGAATAGTATTTTATGTGTAATTCTTCCATTTATTCTGTTTAATTATACAACTAAGATGAAATATTGAAAAAC
CCTTTGTGAAAGTAACTTTTCAAGTAAATGCACAACTTTAGAATTTCTACAAATAAGTTCTTTTAAACAGTCTTTTTATTGTGGATTGTG
AAATCAAAATCTGGAGAAATGCTTATAAAATATACTACTAGCTTTTAAGTTTTAAGAAAGAAGAACGTAAGTTGTACAAAGATATTTGTA
CTTTGACAAACTGAATTTAAATAAACTTTATTTCCTCTCACTATAGTGTGGCTTTAGAATATATCAAGTACAACCTGAATGGACTTTTTG
ATTTTACATTTCCTATATCACTAAAATACTTAAACACAAAAATAAAATTCCACTCCTTTATTTCTTCTTACACCTGCCATTGTCTCTAAT
TCTAAAGAGAGAGCTATAGATTTCTGCAGTTCTAGAGGTGAAGATAGAGACATAGAGAGGCTGTGAAACACACATACAGCCCTGTTAGGT
CTTTTGAATTCACACCTTATTGAAATCAGTGTAGAAGTAGAGTTACCTAAACCTTTATCGCCAATGCACAGCTTGGCCTGTTAAGTTAAA
TGTGGGTGTCAACCAGTGGAAAAGATCAAAGGACCTTTTGCAGCCTAGCTTGCCAATCTTCCAGTAACAACGAGGTGCTACCAATAGGCA
GACTGTGTCTAGAGTCATGCATGGACAAGAGGAAAGTGAAAGTTGAATACTCTCTTCTCAATGGCATAGCTGGACTTGATTAAGTATTGA
CTCATAGAAGAGACATGTATGTTTCCCGGGGCTACCCCTTCATAGCTGCATTTAAAAATGGTGTTCAGGCCACTATGGCTGCTGTGGTTT
GAATATTTTTTTCCCTCGAAAACTCATGTTGAAACTTAACTCCTAATGTAGCAGTACTGAGAGGCAGGGCCCTTAAGAGGTGATTGGGCC
ATGAGGTCTGTGCCCTCCTGAATGGATTAATCCATTCATGGATTAATGGATTATTATGAGTGGGGGACTGGTGACTTTATATGAAAAGGA
AGGAAGAGTGACCTAAGCTAGCATGCTCAGGGTGCACCGTATGTCCCCTGGTCATGTGATGCTATGTGTTACCTTGGGACTTACCTGACA
GCTCTTACCAACAAGAAGGCCATCCCAGATATGGCCTCTCAACCTCAGACTTCTCAGCCTGCCTAACTGTAAGAAATTAATTCTTTTTCT
TTATAAATTACCCAGGTTCTGTTTTAAGCCTCAGAAAATGAACTAAGACAATGCCCTAGATGAGCTGCCAAAATCTGAGCAGATATGAGC
CATCAGAATAGAGACCTGCAGAGGCCCAGGGCACTCAAACATAACTGTGCTTGTCTCAGTCAAACTTAATTGGGAAAAGGAGGAGTAAGA
GCAGGCCCTTTCTGACATGCTTTAGCAGAGATAACTTATCAGGGCTAGTTTAAACAAATGTGTATAGGAAAGGATGTTATTTATATATTC
TTACAAGAGTGTAAGGGCTCACACATTTACTGTACTCAGATCTGAAAGACAATGTTGCTTCTTGATTTTTTTCTATAATCACTATGACCG
TGTTCACGATTCCCTACTCTGCAACTCTCAGCATGCATCATGATGATTCTCTAACACTGTCTGTCACCTTCCTGTATTTCCACAGAGCAT
GCAAGAACTTCTACAAAACTTCTATACCACACAGAAGCTGAAAGAGACTCTGGGGCACTAAATTCAGATCCTTTCTCCACACAGCAATGA
CATTTATCAATCTGACTCAGGTGTGGCTGTTGCCCCTTTTTGATATGGAGGGAACACTGAAAGACAGTTTCCTTCTGGAGTTCCAAATGC
AATATAGAAAAAAAAACCCTGTGACTCTGGATTTTATTTTAAGTTCTCTAACAAGACTCCTACCTTGAGATCTTAGTCTAGGTAAAGAAA
AAAAAAAAAAGGTCATGAAACACAAATGTCCTCAACTGTCATCATTCTATGTTTACTTTCTCCCAATCACATCACCTGAGGTAGAAGAGA
TTTTTCAGTTGCTATTTCTCTTCGTAATGAATTTTCTTTACATCCTGTCCACACTGCTGGAGATACTAAGTCCCAACCTAAATGATGGAA
GGAGCATCTCCCCTCTTGTCTGTGGAAGATATCACATGAACTACCTAATTTTCAAGCATGGATCTCCATATTTCAAAGGAAAGTTTTAAA
AATGTTTTTAAAACTTCAAATATCTCACCACAGTGAATTATGGGTAAGGTGATAATATGTTTAATTAGCTTGATTTAATCATCCCACACT

>16519_16519_2_CHM-KLHL4_CHM_chrX_85282495_ENST00000357749_KLHL4_chrX_86868880_ENST00000373119_length(amino acids)=616AA_BP=39
MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLR
IPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS
NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIR
LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTM
NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNY
VASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER

--------------------------------------------------------------
>16519_16519_3_CHM-KLHL4_CHM_chrX_85282495_ENST00000358786_KLHL4_chrX_86868880_ENST00000373114_length(transcript)=2066nt_BP=123nt
CGTCAAGATGGCGGATACTCTCCCTTCGGAGTTTGATGTGATCGTAATAGGGACGGGTTTGCCTGAATCCATCATTGCAGCTGCATGTTC
AAGAAGTGGCCGGAGAGTTCTGCATGTTGATTCATTAGATACACAACACTCTGAAGACATGAATGCCACCAGATCTGAAGAGCAGTTCCA
TGTTATAAACCACGCAGAGCAAACTCTTCGTAAAATGGAGAACTACTTGAAAGAGAAACAACTATGTGATGTGCTACTGATTGCAGGACA
CCTCCGCATCCCAGCCCATAGGTTGGTTCTCAGCGCAGTGTCTGATTATTTTGCTGCAATGTTTACTAATGATGTGCTTGAAGCCAAACA
AGAAGAGGTCAGGATGGAAGGAGTAGATCCAAATGCACTAAATTCCTTGGTGCAGTATGCTTACACAGGAGTCCTGCAATTGAAAGAAGA
TACCATTGAAAGTTTGCTGGCTGCAGCTTGTCTTCTGCAGCTGACTCAGGTCATTGATGTTTGCTCCAATTTTCTCATAAAGCAGCTCCA
TCCTTCAAACTGCTTAGGGATTCGATCATTTGGAGATGCCCAAGGCTGTACAGAACTTCTGAACGTGGCACACAAATACACTATGGAACA
CTTCATTGAGGTAATAAAAAACCAAGAATTCCTCCTGCTTCCAGCTAATGAAATTTCAAAACTTCTGTGCAGTGATGACATTAATGTGCC
TGATGAAGAGACCATTTTTCATGCTCTAATGCAGTGGGTGGGGCATGATGTGCAGAATAGGCAAGGAGAACTGGGGATGCTGCTTTCTTA
CATCAGACTGCCATTACTCCCACCACAGTTACTGGCAGATCTTGAAACCAGTTCCATGTTTACTGGTGATCTTGAGTGTCAGAAGCTCCT
GATGGAAGCTATGAAGTATCATCTTTTGCCTGAGAGAAGATCCATGATGCAAAGCCCTCGGACAAAGCCTAGAAAATCAACTGTGGGGGC
ACTTTATGCTGTAGGAGGCATGGATGCTATGAAAGGTACTACTACTATTGAAAAATATGACCTCAGGACCAACAGTTGGCTACATATTGG
CACCATGAATGGCCGTAGGCTTCAATTTGGAGTCGCAGTTATTGATAATAAGCTCTATGTCGTGGGAGGAAGAGACGGTTTAAAAACTTT
GAATACAGTGGAATGTTTTAATCCAGTTGGCAAAATCTGGACTGTGATGCCTCCCATGTCAACACATCGGCACGGCTTAGGTGTAGCCAC
TCTTGAAGGACCAATGTATGCTGTAGGTGGTCATGATGGATGGAGCTATCTAAATACTGTAGAAAGATGGGACCCTGAGGGACGACAGTG
GAATTACGTAGCCAGTATGTCAACTCCTAGAAGCACAGTTGGTGTTGTTGCATTAAACAACAAATTATATGCTATTGGTGGACGTGATGG
AAGTTCCTGCCTCAAATCAATGGAATACTTTGACCCACACACTAACAAGTGGAGTTTGTGTGCTCCAATGTCCAAAAGACGTGGAGGTGT
GGGAGTTGCCACATACAATGGATTCTTATATGTTGTAGGGGGGCATGATGCCCCTGCTTCCAACCATTGCTCCAGGCTTTCTGACTGTGT
GGAACGGTATGATCCAAAAGGTGATTCATGGTCAACTGTGGCACCTCTGAGTGTTCCTCGAGATGCTGTTGCTGTGTGCCCTCTTGGAGA
CAAACTCTACGTGGTTGGAGGATATGACGGACATACTTATTTGAACACAGTTGAGTCATATGATGCACAGAGAAATGAATGGAAAGAGAG
CATGCAAGAACTTCTACAAAACTTCTATACCACACAGAAGCTGAAAGAGACTCTGGGGCACTAAATTCAGATCCTTTCTCCACACAGCAA
TGACATTTATCAATCTGACTCAGGTGTGGCTGTTGCCCCTTTTTGATATGGAGGGAACACTGAAAGACAGTTTCCTTCTGGAGTTCCAAA

>16519_16519_3_CHM-KLHL4_CHM_chrX_85282495_ENST00000358786_KLHL4_chrX_86868880_ENST00000373114_length(amino acids)=618AA_BP=39
MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLR
IPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS
NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIR
LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTM
NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNY
VASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER

--------------------------------------------------------------
>16519_16519_4_CHM-KLHL4_CHM_chrX_85282495_ENST00000358786_KLHL4_chrX_86868880_ENST00000373119_length(transcript)=5374nt_BP=123nt
CGTCAAGATGGCGGATACTCTCCCTTCGGAGTTTGATGTGATCGTAATAGGGACGGGTTTGCCTGAATCCATCATTGCAGCTGCATGTTC
AAGAAGTGGCCGGAGAGTTCTGCATGTTGATTCATTAGATACACAACACTCTGAAGACATGAATGCCACCAGATCTGAAGAGCAGTTCCA
TGTTATAAACCACGCAGAGCAAACTCTTCGTAAAATGGAGAACTACTTGAAAGAGAAACAACTATGTGATGTGCTACTGATTGCAGGACA
CCTCCGCATCCCAGCCCATAGGTTGGTTCTCAGCGCAGTGTCTGATTATTTTGCTGCAATGTTTACTAATGATGTGCTTGAAGCCAAACA
AGAAGAGGTCAGGATGGAAGGAGTAGATCCAAATGCACTAAATTCCTTGGTGCAGTATGCTTACACAGGAGTCCTGCAATTGAAAGAAGA
TACCATTGAAAGTTTGCTGGCTGCAGCTTGTCTTCTGCAGCTGACTCAGGTCATTGATGTTTGCTCCAATTTTCTCATAAAGCAGCTCCA
TCCTTCAAACTGCTTAGGGATTCGATCATTTGGAGATGCCCAAGGCTGTACAGAACTTCTGAACGTGGCACACAAATACACTATGGAACA
CTTCATTGAGGTAATAAAAAACCAAGAATTCCTCCTGCTTCCAGCTAATGAAATTTCAAAACTTCTGTGCAGTGATGACATTAATGTGCC
TGATGAAGAGACCATTTTTCATGCTCTAATGCAGTGGGTGGGGCATGATGTGCAGAATAGGCAAGGAGAACTGGGGATGCTGCTTTCTTA
CATCAGACTGCCATTACTCCCACCACAGTTACTGGCAGATCTTGAAACCAGTTCCATGTTTACTGGTGATCTTGAGTGTCAGAAGCTCCT
GATGGAAGCTATGAAGTATCATCTTTTGCCTGAGAGAAGATCCATGATGCAAAGCCCTCGGACAAAGCCTAGAAAATCAACTGTGGGGGC
ACTTTATGCTGTAGGAGGCATGGATGCTATGAAAGGTACTACTACTATTGAAAAATATGACCTCAGGACCAACAGTTGGCTACATATTGG
CACCATGAATGGCCGTAGGCTTCAATTTGGAGTCGCAGTTATTGATAATAAGCTCTATGTCGTGGGAGGAAGAGACGGTTTAAAAACTTT
GAATACAGTGGAATGTTTTAATCCAGTTGGCAAAATCTGGACTGTGATGCCTCCCATGTCAACACATCGGCACGGCTTAGGTGTAGCCAC
TCTTGAAGGACCAATGTATGCTGTAGGTGGTCATGATGGATGGAGCTATCTAAATACTGTAGAAAGATGGGACCCTGAGGGACGACAGTG
GAATTACGTAGCCAGTATGTCAACTCCTAGAAGCACAGTTGGTGTTGTTGCATTAAACAACAAATTATATGCTATTGGTGGACGTGATGG
AAGTTCCTGCCTCAAATCAATGGAATACTTTGACCCACACACTAACAAGTGGAGTTTGTGTGCTCCAATGTCCAAAAGACGTGGAGGTGT
GGGAGTTGCCACATACAATGGATTCTTATATGTTGTAGGGGGGCATGATGCCCCTGCTTCCAACCATTGCTCCAGGCTTTCTGACTGTGT
GGAACGGTATGATCCAAAAGGTGATTCATGGTCAACTGTGGCACCTCTGAGTGTTCCTCGAGATGCTGTTGCTGTGTGCCCTCTTGGAGA
CAAACTCTACGTGGTTGGAGGATATGACGGACATACTTATTTGAACACAGTTGAGTCATATGATGCACAGAGAAATGAATGGAAAGAGGA
AGTTCCTGTTAACATTGGAAGAGCTGGTGCATGTGTTGTAGTGGTGAAGCTACCCTAAAGCTATCTATCTTTATCAAATGGAATGAAACT
AGATAATTTCAAGAAACTGAGTAGGACAAAGGGAGAAAGAAATACATGTTCTTTTTCCTGCAATTAATAATCAGACTGGAAAATTGTTGT
ATCATTTTAATTTGTAGTTACAATTGCTTTCATTCGTGAAGCCGAAACGTTTTTAAACATGAATTACATATGAATTATTAAGCATATGTG
CTTTCGCAGCTGATAATATAAAAGGAAATCCCACAGTCTAGATATAGCCCCATTACTACAAAATGCTAAAATATTTAATGAAAATTGATG
GTGGCCACAGTGTGCAGGTTATAAAAGCATTAATACATTTCAAGGTAAGAGCCTTAAAAGTTAAAAACATTTTCAGTTTTTTTTTAAAAA
ACGTACTCTTATTATCTGGAACATAGAAATATAAAAGGTAACATCTAAAGCTTAGAATAGTGTGATTTTTAGTAAGCCATTATTCTCCTA
TTCAAATAATATCCCAAAGAGCTAAACAATTCCTTACATTTACCAAGAGGAAAGCTTTTACTGTGTTGAAGCTAAAAAAATAATGGCTCT
TTGACAAAACTTGTTATGTTGATCGCGGTATGTCAAAATTTTTACAGGTTTGCTCATCTGCCAGAGCACACATATAAATTTGGTATTTCT
TAACATATTATCTTGTTAGATTTGTTACCAGTAAAATATTACTGTAATTTCATATACACAGTCTATACAATGAAATAATGAATATTTATC
ATATTGATACAAACTGTGACCTCAGCTTCAGAGTGTCAGGGCCTCACTTGTATAGAATGTAATGTTCTCCTCAAACATTTATGTTAACTC
TATAAACAAATATCGTTAAGTTAAACAAGTTTTCAAAAACAAAACAATTTTTAAAGTACCTTAAAATTGAGGATGTTACTCAGTGTTAAC
ACATGGGAACACCAAAATATTCAATAAGCCTGGTCAATTCTATAGTTATCTTTTTTGTACCAACACATGCTTTTCTGTTACTGTTATATT
ATCCAGTAGAAAATGTTAGGATATGTGTGCTATATAAAAAAAAAAAAAGACTTGTTAAGTTTTAAAATAACAAAAATGGCTAGTTGAATA
GTATTTTATGTGTAATTCTTCCATTTATTCTGTTTAATTATACAACTAAGATGAAATATTGAAAAACCCTTTGTGAAAGTAACTTTTCAA
GTAAATGCACAACTTTAGAATTTCTACAAATAAGTTCTTTTAAACAGTCTTTTTATTGTGGATTGTGAAATCAAAATCTGGAGAAATGCT
TATAAAATATACTACTAGCTTTTAAGTTTTAAGAAAGAAGAACGTAAGTTGTACAAAGATATTTGTACTTTGACAAACTGAATTTAAATA
AACTTTATTTCCTCTCACTATAGTGTGGCTTTAGAATATATCAAGTACAACCTGAATGGACTTTTTGATTTTACATTTCCTATATCACTA
AAATACTTAAACACAAAAATAAAATTCCACTCCTTTATTTCTTCTTACACCTGCCATTGTCTCTAATTCTAAAGAGAGAGCTATAGATTT
CTGCAGTTCTAGAGGTGAAGATAGAGACATAGAGAGGCTGTGAAACACACATACAGCCCTGTTAGGTCTTTTGAATTCACACCTTATTGA
AATCAGTGTAGAAGTAGAGTTACCTAAACCTTTATCGCCAATGCACAGCTTGGCCTGTTAAGTTAAATGTGGGTGTCAACCAGTGGAAAA
GATCAAAGGACCTTTTGCAGCCTAGCTTGCCAATCTTCCAGTAACAACGAGGTGCTACCAATAGGCAGACTGTGTCTAGAGTCATGCATG
GACAAGAGGAAAGTGAAAGTTGAATACTCTCTTCTCAATGGCATAGCTGGACTTGATTAAGTATTGACTCATAGAAGAGACATGTATGTT
TCCCGGGGCTACCCCTTCATAGCTGCATTTAAAAATGGTGTTCAGGCCACTATGGCTGCTGTGGTTTGAATATTTTTTTCCCTCGAAAAC
TCATGTTGAAACTTAACTCCTAATGTAGCAGTACTGAGAGGCAGGGCCCTTAAGAGGTGATTGGGCCATGAGGTCTGTGCCCTCCTGAAT
GGATTAATCCATTCATGGATTAATGGATTATTATGAGTGGGGGACTGGTGACTTTATATGAAAAGGAAGGAAGAGTGACCTAAGCTAGCA
TGCTCAGGGTGCACCGTATGTCCCCTGGTCATGTGATGCTATGTGTTACCTTGGGACTTACCTGACAGCTCTTACCAACAAGAAGGCCAT
CCCAGATATGGCCTCTCAACCTCAGACTTCTCAGCCTGCCTAACTGTAAGAAATTAATTCTTTTTCTTTATAAATTACCCAGGTTCTGTT
TTAAGCCTCAGAAAATGAACTAAGACAATGCCCTAGATGAGCTGCCAAAATCTGAGCAGATATGAGCCATCAGAATAGAGACCTGCAGAG
GCCCAGGGCACTCAAACATAACTGTGCTTGTCTCAGTCAAACTTAATTGGGAAAAGGAGGAGTAAGAGCAGGCCCTTTCTGACATGCTTT
AGCAGAGATAACTTATCAGGGCTAGTTTAAACAAATGTGTATAGGAAAGGATGTTATTTATATATTCTTACAAGAGTGTAAGGGCTCACA
CATTTACTGTACTCAGATCTGAAAGACAATGTTGCTTCTTGATTTTTTTCTATAATCACTATGACCGTGTTCACGATTCCCTACTCTGCA
ACTCTCAGCATGCATCATGATGATTCTCTAACACTGTCTGTCACCTTCCTGTATTTCCACAGAGCATGCAAGAACTTCTACAAAACTTCT
ATACCACACAGAAGCTGAAAGAGACTCTGGGGCACTAAATTCAGATCCTTTCTCCACACAGCAATGACATTTATCAATCTGACTCAGGTG
TGGCTGTTGCCCCTTTTTGATATGGAGGGAACACTGAAAGACAGTTTCCTTCTGGAGTTCCAAATGCAATATAGAAAAAAAAACCCTGTG
ACTCTGGATTTTATTTTAAGTTCTCTAACAAGACTCCTACCTTGAGATCTTAGTCTAGGTAAAGAAAAAAAAAAAAAGGTCATGAAACAC
AAATGTCCTCAACTGTCATCATTCTATGTTTACTTTCTCCCAATCACATCACCTGAGGTAGAAGAGATTTTTCAGTTGCTATTTCTCTTC
GTAATGAATTTTCTTTACATCCTGTCCACACTGCTGGAGATACTAAGTCCCAACCTAAATGATGGAAGGAGCATCTCCCCTCTTGTCTGT
GGAAGATATCACATGAACTACCTAATTTTCAAGCATGGATCTCCATATTTCAAAGGAAAGTTTTAAAAATGTTTTTAAAACTTCAAATAT
CTCACCACAGTGAATTATGGGTAAGGTGATAATATGTTTAATTAGCTTGATTTAATCATCCCACACTGTATACATATGCCAAAATATCAT

>16519_16519_4_CHM-KLHL4_CHM_chrX_85282495_ENST00000358786_KLHL4_chrX_86868880_ENST00000373119_length(amino acids)=616AA_BP=39
MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLR
IPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPS
NCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIR
LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTM
NGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNY
VASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVER

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CHM-KLHL4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CHM-KLHL4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CHM-KLHL4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source