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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHMP3-EPB41L5 (FusionGDB2 ID:16537)

Fusion Gene Summary for CHMP3-EPB41L5

check button Fusion gene summary
Fusion gene informationFusion gene name: CHMP3-EPB41L5
Fusion gene ID: 16537
HgeneTgene
Gene symbol

CHMP3

EPB41L5

Gene ID

100526767

57669

Gene nameRNF103-CHMP3 readthrougherythrocyte membrane protein band 4.1 like 5
SynonymsCGI149|CHMP3|NEDF|RNF103-VPS24|VPS24|hVps24BE37|LULU|LULU1|YMO1|YRT
Cytomap

2p11.2

2q14.2

Type of geneprotein-codingprotein-coding
DescriptionRNF103-CHMP3 proteinCharged multivesicular body protein 3Chromatin-modifying protein 3Neuroendocrine differentiation factorRNF103-CHMP3 read-throughRNF103-VPS24 readthroughVacuolar protein sorting-associated protein 24band 4.1-like protein 5yurt homolog
Modification date2020031320200313
UniProtAcc

Q9Y3E7

Q9HCM4

Ensembl transtripts involved in fusion geneENST00000263856, ENST00000409727, 
ENST00000409225, ENST00000439940, 
ENST00000494623, 		ENST00000331393, 
ENST00000443124, ENST00000452780, 
ENST00000488691, ENST00000263713, 
ENST00000443902, 
Fusion gene scores* DoF score10 X 6 X 6=3609 X 9 X 4=324
# samples 119
** MAII scorelog2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHMP3 [Title/Abstract] AND EPB41L5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHMP3(86790426)-EPB41L5(120900578), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHMP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPB41L5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-4267CHMP3chr2

86790426

-EPB41L5chr2

120900578

+


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Fusion Gene ORF analysis for CHMP3-EPB41L5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000263856ENST00000331393CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000263856ENST00000443124CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000263856ENST00000452780CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000263856ENST00000488691CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000409727ENST00000331393CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000409727ENST00000443124CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000409727ENST00000452780CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5CDS-intronENST00000409727ENST00000488691CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5UTR-3CDSENST00000409225ENST00000263713CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5UTR-3CDSENST00000409225ENST00000443902CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5UTR-intronENST00000409225ENST00000331393CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5UTR-intronENST00000409225ENST00000443124CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5UTR-intronENST00000409225ENST00000452780CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
5UTR-intronENST00000409225ENST00000488691CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
In-frameENST00000263856ENST00000263713CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
In-frameENST00000263856ENST00000443902CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
In-frameENST00000409727ENST00000263713CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
In-frameENST00000409727ENST00000443902CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-3CDSENST00000439940ENST00000263713CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-3CDSENST00000439940ENST00000443902CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-3CDSENST00000494623ENST00000263713CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-3CDSENST00000494623ENST00000443902CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000439940ENST00000331393CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000439940ENST00000443124CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000439940ENST00000452780CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000439940ENST00000488691CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000494623ENST00000331393CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000494623ENST00000443124CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000494623ENST00000452780CHMP3chr2

86790426

-EPB41L5chr2

120900578

+
intron-intronENST00000494623ENST00000488691CHMP3chr2

86790426

-EPB41L5chr2

120900578

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263856CHMP3chr286790426-ENST00000263713EPB41L5chr2120900578+4989174129776215
ENST00000263856CHMP3chr286790426-ENST00000443902EPB41L5chr2120900578+1600174129638169
ENST00000409727CHMP3chr286790426-ENST00000263713EPB41L5chr2120900578+48867126673215
ENST00000409727CHMP3chr286790426-ENST00000443902EPB41L5chr2120900578+14977126535169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263856ENST00000263713CHMP3chr286790426-EPB41L5chr2120900578+0.0020359730.997964
ENST00000263856ENST00000443902CHMP3chr286790426-EPB41L5chr2120900578+0.0043035870.9956964
ENST00000409727ENST00000263713CHMP3chr286790426-EPB41L5chr2120900578+0.0020300490.9979699
ENST00000409727ENST00000443902CHMP3chr286790426-EPB41L5chr2120900578+0.0046697170.99533033

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Fusion Genomic Features for CHMP3-EPB41L5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHMP3chr286790426-EPB41L5chr2120900578+0.0055893690.9944106
CHMP3chr286790426-EPB41L5chr2120900578+0.0055893690.9944106

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CHMP3-EPB41L5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86790426/chr2:120900578)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHMP3

Q9Y3E7

EPB41L5

Q9HCM4

FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:15707591, ECO:0000269|PubMed:16740483, ECO:0000269|PubMed:17331679, ECO:0000269|PubMed:18076377}.FUNCTION: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPB41L5chr2:86790426chr2:120900578ENST0000033139301743_3270506.0DomainFERM
TgeneEPB41L5chr2:86790426chr2:120900578ENST0000044312401743_3270506.0DomainFERM

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHMP3chr2:86790426chr2:120900578ENST00000263856-16141_22215223.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000263856-1622_5415223.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409225-15141_2220157.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409225-1522_540157.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409727-16141_22215183.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409727-1622_5415183.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000439940-18141_2220252.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000439940-1822_540252.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP3chr2:86790426chr2:120900578ENST00000263856-16201_21115223.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409225-15201_2110157.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409727-16201_21115183.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790426chr2:120900578ENST00000439940-18201_2110252.0MotifNote=MIT-interacting motif
HgeneCHMP3chr2:86790426chr2:120900578ENST00000263856-1659_6415223.0RegionNote=Important for autoinhibitory function
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409225-1559_640157.0RegionNote=Important for autoinhibitory function
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409727-1659_6415183.0RegionNote=Important for autoinhibitory function
HgeneCHMP3chr2:86790426chr2:120900578ENST00000439940-1859_640252.0RegionNote=Important for autoinhibitory function
TgeneEPB41L5chr2:86790426chr2:120900578ENST00000263713172543_327533734.0DomainFERM
TgeneEPB41L5chr2:86790426chr2:120900578ENST00000443902172443_327533688.0DomainFERM
TgeneEPB41L5chr2:86790426chr2:120900578ENST00000452780162443_327533733.0DomainFERM


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Fusion Gene Sequence for CHMP3-EPB41L5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16537_16537_1_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000263856_EPB41L5_chr2_120900578_ENST00000263713_length(transcript)=4989nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGAGGAA
GTGGTGAAGTTGACTGAGAAATGCCTTAATAATGTCATTGAGAGCCCAGGATTGAATGTCATGAGAGTTCCTCCTGACTTCAAGAGTAAC
ATTTTGAAGGCTCAAGTAGAAGCAGTGCATAAGGTTACAAAAGAAGATAGCTTATTAAGTCATAAAAATGCCAATGTTCAGGATGCTGCC
ACAAACAGTGCTGTGTTAAATGAGAATAATGTGCCCCTCCCCAAAGAGTCTCTTGAGACTCTGATGCTTATCACACCTGCCGACAGTGGT
TCTGTTCTAAAGGAAGCTACAGATGAATTGGATGCCTTGCTTGCATCTCTAACTGAGAATCTAATTGATCACACAGTTGCACCTCAGGTG
TCTTCCACATCCATGATCACACCCCGGTGGATTGTTCCGCAGAGTGGTGCCATGTCTAATGGACTTGCGGGATGTGAAATGCTTTTGACA
GGGAAGGAGGGACATGGTAATAAAGATGGAATCTCACTGATCTCTCCCCCAGCGCCATTCTTGGTAGATGCTGTGACCAGCTCTGGTCCC
ATTTTGGCAGAAGAAGCTGTCCTGAAGCAGAAGTGTTTACTGACCACTGAGCTCTGAGGGCCTGTAGCTGGAATACGCATCTCTCCAGCA
TTCCGTCCTGGGATCCGTTTCAGCTAGAATATGTTGGATTCAGGAGCTTGTCCATTATTTGTAGGTAAAAAAAGCTGCACGTAGATTTGA
CTTCAACTCCGTAAAAAAGACAGCTGTATTTTCCGTCCAACTGGAATTGTTGAATCACACTGCATAGCTGCCCAAAAGAGAGTGTTTGGT
CTTGAACTTTCTATACTTTTATAAATGTTACAAATTCCCGAAAGAAGGGAATTTCTTTTTCTGGGGTTTCCTTCAAACTCTTGGCTCCAC
CTAGCGGTTCTATTTGTTCATAACAACTTCATAACAAGCCTGCCTCTGGTAGTCAACAGCCTTTTGAAAGCTATTTCCATCTAGTATCAG
GGTGAGAGCATCCTTGATCTGGCTGCCTGTTAGAGAAATTGCACTTTTCCTGACTTACCTAGAAATCAAGAATTTAGGAAATTAATGTGG
ACACTATAAAGGCAGACTTAGGGCCAACTTTTTTTTTTTTTTACAATTATTACAACACTAAAGAGAAGTTTAGAATATAGAGAGTTTTTA
AATGTCTCCCATTCTTTTGATTTCTTACTGTACTGGCTATCTTAATATTTCAAGTTTACATCAAGATAAACCCTGAGAAGAACTACGGAG
AAATCAAATAAAATCCTGTCATATTTTTTTCACCCTGCCTTTCCACAGGAAGCACTCACAGGCACCACACACGTATCATGTAACTTATCA
GTGGGGTGGGTTACTGTTGAAGAGACCCTGGGGCATTTACCTCAGGCATCTGCACTCCTCCGAGCCCGGTGGAGAATGCAGGCTGCTGTA
GTCTCAGGTAATGAAGGCACAGCACAGCAGTACTCCACATTGTTTCCTATTTGGACATAGACTTCATTTCCTTTCAGTATAAGCTGAATA
AATTTAGAGCTTTCAAACTGGAAAAAAAAATGAAACAAAACAAATACACCAAGACCAAAATAGGCAATAGGAACAGGGGTGAAGGGATGT
TGTTTCTTAAATACCTACCATGTATGAAGCTATACACAGCATATACCGAAAGAACCTGCATTGCACTAGGAATTCTGTGTTAGTTTAAAA
GAGATCTCTAAAACTTCCCCATCCCTTTGGGCCTGTACAAAGAAATTCTGGATGTTAAAATAATATATACTCATCACAGAAAAATAAAGT
ATAGCAATGTCCATCTGTAATTCTAATACCCAGAAATAACGCTATTTAGCTTTATAATTTTCGAATGAACAAGGTAAACCTCGGTTGCCA
TGGGGAAGAAGGATGATGTGGAAACCATATTGGTAAAGTTGTTAATCCCTCGTTATGGAGAACTGATCTTAAGCTATACCTCCTGGAATT
TGCTTTCTAGTTTTCTGTCCTGCAATATGTATATAATTAAGCACTAATTTGTACTGCTTAGCATAAAAGAACATCCAGTCTTAGATCCTT
AAAACTTCATGGATTGGACTTTCCTGGGCTCCTTATAACATAATCGTGTGTCCAGGCAAACGCACACTAGTGTCTGACTGGAAAGCTCAG
GAATTTTAATCTTGCACTGTTTCCCAGGGAGCTGTAGTGATTGGAACCCACGTTTGCACAAAACATTTTTGCAGAAGGAAAGTCAACACT
TCTTGCTGGCTGCCTCCCCTTAGCCATTATGCTAAAAACAGCTTCTGAGTTTCACTGGTGGGGCTCTTGCCAGTTCTTAATTATAGGACA
TATTTTCTCAAAGCTGAAGGTGACACCTAGAACCAGGGGCTTGACCCAGGACATGATGGAATGAGCATCAAATTTTCAGTGTCTTGGCAA
CCGTAGATGTCCTACAGGGTTACCGTTGTGCTGCTCACCACAGAGCAGCTGAGGCATTATGCCTTGGAAGACCTAAATCTCCCATCCAGT
TCAGGAGGTGACAACATCCTTATTTTAAACTTCCTAAAATTAGGAATTAGGTAGTTGGACATAGTCTGTGACCTTTATGTCGTTGGATAC
CTGTATTCTTGACAGTTAGAATATTGGTAGGGACTTTGTTAAAATTCACTTGAATTTCAAGCTCAGAGGAAACTTTGTCTCATGCCCTGA
CATGAAGTGGCAAACACGGAAGTTCATACTTGAATGCTGAATTGGCCCCGACAGATTAAATGCGTGTTGGGGATTGGTTTCCTGTCATAG
CTGCTGCTGCTGCCATGCGCAGAGCTGCTGTAACAGCTCTTCCTGTTCTGCTCCCCTGAGAACAGTGTGGTGGGGAGAGGCAGGGCTGAG
GTGGTCTACGAATGTGGCAGGTAGGGAAGGGGAGATGTCTGTCTCTTGAGAAGAGAGAGGCATGTGTGCCGGCATCCTTGATGGGTTCAA
AGAGAAAGGTTGGAGATGATAGTGGGTGAGAAGCAGGCTGGTGAGACTGGGCTGAGGTTGGAGAAGGGGCAGCCGGGGGCACTGCTGAGG
GTTTGCCGTGCACGCCTCGGACGGAGCACGGTGGGGTGGCGGGGAGCAGATAGTGCTGCCTCCCTGCGGGCAGACAGGAGAGGAACCTCA
ACTCAGTCCATTTCATAGCCCTGATAGGGGAAGTGGGAGTTGACAGGATGGTTTAAAATAAGACGTGAAGGTTTCAGTTACCTGCTCTAG
ACTTTGCCTGAGAACTTGTAAATTAATCAGTGAGACCTAATTTGTGACATGTCAGTAGCATCATCTTTTGACACACAGGAGGTCATGGTC
ATTTCATTCCTACTCTTCAGGAGACACTGCTGAACAGAGGAATGATTCTGTTCCTTGTGTGCTTACTTCCTTAACATTTATACATTGTTT
TAAGAAAAAACTTTTAAAAATATTTCTTATAGTCTCCTAACATTTGTCTCTAGCCTTTGCCTTTGTACAATCACAGATATCCTATGGAGA
TTTAAGGATGAAAGCCCTGAGTTGTTCTTGGGTTCTTGGATCTGGACTACTTGTTATCTTATGCTTCTCACTTCTGGCTAAAACTTGCAC
CTCTTCTTCTCTTAGCTAAGCCCCAAAATGAAGATTTCCTTCAGAAGTCTTGTTAGCAGAATTATTTATCAGTCACAGAGAGAAAAATCT
GCTATTTTTCTAAGTAAGAGTCTCGAGAAGCAGAGTTTTTGTCTTGTCATTGAGAGGAGTCAGCAGTCTTGTTCTGTAAAGGACCAGAGA
TGGTAAATACTGTCCCACTCAGCTCTGCTGGCGCAGTACAGCAGCAGCAGCCCCAGCACAGCTGTGTTCCTGCGGAGTCCCCTTTACAAA
GCCGCTGACCCCTGATGTGAAACTTTGTAGAGCAGCAGAGTGGCTGCGTGAAACGGGAGGCTGGCAGGTCCTCAGATAGGTTCTGCAGTG
TTACCTGTCACTTGGAGGCAGCCAACACTTCTGGACATTGCATCCTTATTCACACATGTGGCAGCTGAACGAGGTGCTGTTGTGGGTGTC
TCAGCTCTGAGGGTCTTTGTGAGCTCCCACTGTTGTGGGTGTCTCAGCTCTGAGGGTCTTTGTGAGCTCCCACTGTTGTGGGTGTCTCAG
CTCTGAGGGTCTTTGTGAGTTCCCACCAACTTTTAATTATTCATGCCCTTGACCATGTGGTTGCTTGGAGACCTGGGGTCTTCTGCAGAC
TGAAGAAGACACATTTCTAGATTATTTGTCCTTTTTATCCTCTCAAAAATTTAAACACTGTACCTCTTCAGTGGTCAGAAGAAAGTTGGA
AACTTTTCCTACATATTAGGCGTTAGTATGAGGACATTTGTTTGAATTATAGAAATTTGCCCTGAGCTGAACTGGGTTGTGTTAACACAT
TGGTAGAGCTATGATTCCTTCCCAGTTCTAAGAGATACGATCTGTAAGTCCCTATGTCACCACATTGCTTGAGATGATCATTCAGTTACT
TGTCAGGATTTCTCCTCTTCAGAGAGATTTTTTTTTATAGCACAGATTCCTTTGCCCCTTTTATCTCCTTATCTGGATATGATAAGTGGT
TATGAGGGTCTCACTAACTATTTTGTGTTTACCTTTTATATGTGTAAAACTTTGCAGTAGCATTTAAAGTGTAATTTATTTTTCTATCAA
GTGCACTATTCATTTAGTGTGTTCCAGTTTTATATGACTTGTATTAGAAACACTGCACTGAGTTGTTTGTACACTGAAATGAGAACTCTA

>16537_16537_1_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000263856_EPB41L5_chr2_120900578_ENST00000263713_length(amino acids)=215AA_BP=15
MGLFGKTQEKPPKELEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPL
PKESLETLMLITPADSGSVLKEATDELDALLASLTENLIDHTVAPQVSSTSMITPRWIVPQSGAMSNGLAGCEMLLTGKEGHGNKDGISL

--------------------------------------------------------------
>16537_16537_2_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000263856_EPB41L5_chr2_120900578_ENST00000443902_length(transcript)=1600nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGAGGAA
GTGGTGAAGTTGACTGAGAAATGCCTTAATAATGTCATTGAGAGCCCAGGATTGAATGTCATGAGAGTTCCTCCTGACTTCAAGAGTAAC
ATTTTGAAGGCTCAAGTAGAAGCAGTGCATAAGGTTACAAAAGAAGATAGCTTATTAAGTCATAAAAATGCCAATGTTCAGGATGCTGCC
ACAAACAGTGCTGTGTTAAATGAGAATAATGTGCCCCTCCCCAAAGAGTCTCTTGAGACTCTGATGCTTATCACACCTGCCGACAGTGGT
TCTGTTCTAAAGGAAGCTACAGATGAATTGGATGCCTTGCTTGCATCTCTAACTGAGAATCTAATTGATCACACAGTTGCACCTCAGGTG
TCTTCCACATCCATGATCACACCCCGGTGGATTGTTCCGCTCTGGTCCCATTTTGGCAGAAGAAGCTGTCCTGAAGCAGAAGTGTTTACT
GACCACTGAGCTCTGAGGGCCTGTAGCTGGAATACGCATCTCTCCAGCATTCCGTCCTGGGATCCGTTTCAGCTAGAATATGTTGGATTC
AGGAGCTTGTCCATTATTTGTAGGTAAAAAAAGCTGCACGTAGATTTGACTTCAACTCCGTAAAAAAGACAGCTGTATTTTCCGTCCAAC
TGGAATTGTTGAATCACACTGCATAGCTGCCCAAAAGAGAGTGTTTGGTCTTGAACTTTCTATACTTTTATAAATGTTACAAATTCCCGA
AAGAAGGGAATTTCTTTTTCTGGGGTTTCCTTCAAACTCTTGGCTCCACCTAGCGGTTCTATTTGTTCATAACAACTTCATAACAAGCCT
GCCTCTGGTAGTCAACAGCCTTTTGAAAGCTATTTCCATCTAGTATCAGGGTGAGAGCATCCTTGATCTGGCTGCCTGTTAGAGAAATTG
CACTTTTCCTGACTTACCTAGAAATCAAGAATTTAGGAAATTAATGTGGACACTATAAAGGCAGACTTAGGGCCAACTTTTTTTTTTTTT
TACAATTATTACAACACTAAAGAGAAGTTTAGAATATAGAGAGTTTTTAAATGTCTCCCATTCTTTTGATTTCTTACTGTACTGGCTATC
TTAATATTTCAAGTTTACATCAAGATAAACCCTGAGAAGAACTACGGAGAAATCAAATAAAATCCTGTCATATTTTTTTCACCCTGCCTT
TCCACAGGAAGCACTCACAGGCACCACACACGTATCATGTAACTTATCAGTGGGGTGGGTTACTGTTGAAGAGACCCTGGGGCATTTACC
TCAGGCATCTGCACTCCTCCGAGCCCGGTGGAGAATGCAGGCTGCTGTAGTCTCAGGTAATGAAGGCACAGCACAGCAGTACTCCACATT

>16537_16537_2_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000263856_EPB41L5_chr2_120900578_ENST00000443902_length(amino acids)=169AA_BP=15
MGLFGKTQEKPPKELEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPL

--------------------------------------------------------------
>16537_16537_3_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000409727_EPB41L5_chr2_120900578_ENST00000263713_length(transcript)=4886nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGAGGAAGTGGTGAAGTTGA
CTGAGAAATGCCTTAATAATGTCATTGAGAGCCCAGGATTGAATGTCATGAGAGTTCCTCCTGACTTCAAGAGTAACATTTTGAAGGCTC
AAGTAGAAGCAGTGCATAAGGTTACAAAAGAAGATAGCTTATTAAGTCATAAAAATGCCAATGTTCAGGATGCTGCCACAAACAGTGCTG
TGTTAAATGAGAATAATGTGCCCCTCCCCAAAGAGTCTCTTGAGACTCTGATGCTTATCACACCTGCCGACAGTGGTTCTGTTCTAAAGG
AAGCTACAGATGAATTGGATGCCTTGCTTGCATCTCTAACTGAGAATCTAATTGATCACACAGTTGCACCTCAGGTGTCTTCCACATCCA
TGATCACACCCCGGTGGATTGTTCCGCAGAGTGGTGCCATGTCTAATGGACTTGCGGGATGTGAAATGCTTTTGACAGGGAAGGAGGGAC
ATGGTAATAAAGATGGAATCTCACTGATCTCTCCCCCAGCGCCATTCTTGGTAGATGCTGTGACCAGCTCTGGTCCCATTTTGGCAGAAG
AAGCTGTCCTGAAGCAGAAGTGTTTACTGACCACTGAGCTCTGAGGGCCTGTAGCTGGAATACGCATCTCTCCAGCATTCCGTCCTGGGA
TCCGTTTCAGCTAGAATATGTTGGATTCAGGAGCTTGTCCATTATTTGTAGGTAAAAAAAGCTGCACGTAGATTTGACTTCAACTCCGTA
AAAAAGACAGCTGTATTTTCCGTCCAACTGGAATTGTTGAATCACACTGCATAGCTGCCCAAAAGAGAGTGTTTGGTCTTGAACTTTCTA
TACTTTTATAAATGTTACAAATTCCCGAAAGAAGGGAATTTCTTTTTCTGGGGTTTCCTTCAAACTCTTGGCTCCACCTAGCGGTTCTAT
TTGTTCATAACAACTTCATAACAAGCCTGCCTCTGGTAGTCAACAGCCTTTTGAAAGCTATTTCCATCTAGTATCAGGGTGAGAGCATCC
TTGATCTGGCTGCCTGTTAGAGAAATTGCACTTTTCCTGACTTACCTAGAAATCAAGAATTTAGGAAATTAATGTGGACACTATAAAGGC
AGACTTAGGGCCAACTTTTTTTTTTTTTTACAATTATTACAACACTAAAGAGAAGTTTAGAATATAGAGAGTTTTTAAATGTCTCCCATT
CTTTTGATTTCTTACTGTACTGGCTATCTTAATATTTCAAGTTTACATCAAGATAAACCCTGAGAAGAACTACGGAGAAATCAAATAAAA
TCCTGTCATATTTTTTTCACCCTGCCTTTCCACAGGAAGCACTCACAGGCACCACACACGTATCATGTAACTTATCAGTGGGGTGGGTTA
CTGTTGAAGAGACCCTGGGGCATTTACCTCAGGCATCTGCACTCCTCCGAGCCCGGTGGAGAATGCAGGCTGCTGTAGTCTCAGGTAATG
AAGGCACAGCACAGCAGTACTCCACATTGTTTCCTATTTGGACATAGACTTCATTTCCTTTCAGTATAAGCTGAATAAATTTAGAGCTTT
CAAACTGGAAAAAAAAATGAAACAAAACAAATACACCAAGACCAAAATAGGCAATAGGAACAGGGGTGAAGGGATGTTGTTTCTTAAATA
CCTACCATGTATGAAGCTATACACAGCATATACCGAAAGAACCTGCATTGCACTAGGAATTCTGTGTTAGTTTAAAAGAGATCTCTAAAA
CTTCCCCATCCCTTTGGGCCTGTACAAAGAAATTCTGGATGTTAAAATAATATATACTCATCACAGAAAAATAAAGTATAGCAATGTCCA
TCTGTAATTCTAATACCCAGAAATAACGCTATTTAGCTTTATAATTTTCGAATGAACAAGGTAAACCTCGGTTGCCATGGGGAAGAAGGA
TGATGTGGAAACCATATTGGTAAAGTTGTTAATCCCTCGTTATGGAGAACTGATCTTAAGCTATACCTCCTGGAATTTGCTTTCTAGTTT
TCTGTCCTGCAATATGTATATAATTAAGCACTAATTTGTACTGCTTAGCATAAAAGAACATCCAGTCTTAGATCCTTAAAACTTCATGGA
TTGGACTTTCCTGGGCTCCTTATAACATAATCGTGTGTCCAGGCAAACGCACACTAGTGTCTGACTGGAAAGCTCAGGAATTTTAATCTT
GCACTGTTTCCCAGGGAGCTGTAGTGATTGGAACCCACGTTTGCACAAAACATTTTTGCAGAAGGAAAGTCAACACTTCTTGCTGGCTGC
CTCCCCTTAGCCATTATGCTAAAAACAGCTTCTGAGTTTCACTGGTGGGGCTCTTGCCAGTTCTTAATTATAGGACATATTTTCTCAAAG
CTGAAGGTGACACCTAGAACCAGGGGCTTGACCCAGGACATGATGGAATGAGCATCAAATTTTCAGTGTCTTGGCAACCGTAGATGTCCT
ACAGGGTTACCGTTGTGCTGCTCACCACAGAGCAGCTGAGGCATTATGCCTTGGAAGACCTAAATCTCCCATCCAGTTCAGGAGGTGACA
ACATCCTTATTTTAAACTTCCTAAAATTAGGAATTAGGTAGTTGGACATAGTCTGTGACCTTTATGTCGTTGGATACCTGTATTCTTGAC
AGTTAGAATATTGGTAGGGACTTTGTTAAAATTCACTTGAATTTCAAGCTCAGAGGAAACTTTGTCTCATGCCCTGACATGAAGTGGCAA
ACACGGAAGTTCATACTTGAATGCTGAATTGGCCCCGACAGATTAAATGCGTGTTGGGGATTGGTTTCCTGTCATAGCTGCTGCTGCTGC
CATGCGCAGAGCTGCTGTAACAGCTCTTCCTGTTCTGCTCCCCTGAGAACAGTGTGGTGGGGAGAGGCAGGGCTGAGGTGGTCTACGAAT
GTGGCAGGTAGGGAAGGGGAGATGTCTGTCTCTTGAGAAGAGAGAGGCATGTGTGCCGGCATCCTTGATGGGTTCAAAGAGAAAGGTTGG
AGATGATAGTGGGTGAGAAGCAGGCTGGTGAGACTGGGCTGAGGTTGGAGAAGGGGCAGCCGGGGGCACTGCTGAGGGTTTGCCGTGCAC
GCCTCGGACGGAGCACGGTGGGGTGGCGGGGAGCAGATAGTGCTGCCTCCCTGCGGGCAGACAGGAGAGGAACCTCAACTCAGTCCATTT
CATAGCCCTGATAGGGGAAGTGGGAGTTGACAGGATGGTTTAAAATAAGACGTGAAGGTTTCAGTTACCTGCTCTAGACTTTGCCTGAGA
ACTTGTAAATTAATCAGTGAGACCTAATTTGTGACATGTCAGTAGCATCATCTTTTGACACACAGGAGGTCATGGTCATTTCATTCCTAC
TCTTCAGGAGACACTGCTGAACAGAGGAATGATTCTGTTCCTTGTGTGCTTACTTCCTTAACATTTATACATTGTTTTAAGAAAAAACTT
TTAAAAATATTTCTTATAGTCTCCTAACATTTGTCTCTAGCCTTTGCCTTTGTACAATCACAGATATCCTATGGAGATTTAAGGATGAAA
GCCCTGAGTTGTTCTTGGGTTCTTGGATCTGGACTACTTGTTATCTTATGCTTCTCACTTCTGGCTAAAACTTGCACCTCTTCTTCTCTT
AGCTAAGCCCCAAAATGAAGATTTCCTTCAGAAGTCTTGTTAGCAGAATTATTTATCAGTCACAGAGAGAAAAATCTGCTATTTTTCTAA
GTAAGAGTCTCGAGAAGCAGAGTTTTTGTCTTGTCATTGAGAGGAGTCAGCAGTCTTGTTCTGTAAAGGACCAGAGATGGTAAATACTGT
CCCACTCAGCTCTGCTGGCGCAGTACAGCAGCAGCAGCCCCAGCACAGCTGTGTTCCTGCGGAGTCCCCTTTACAAAGCCGCTGACCCCT
GATGTGAAACTTTGTAGAGCAGCAGAGTGGCTGCGTGAAACGGGAGGCTGGCAGGTCCTCAGATAGGTTCTGCAGTGTTACCTGTCACTT
GGAGGCAGCCAACACTTCTGGACATTGCATCCTTATTCACACATGTGGCAGCTGAACGAGGTGCTGTTGTGGGTGTCTCAGCTCTGAGGG
TCTTTGTGAGCTCCCACTGTTGTGGGTGTCTCAGCTCTGAGGGTCTTTGTGAGCTCCCACTGTTGTGGGTGTCTCAGCTCTGAGGGTCTT
TGTGAGTTCCCACCAACTTTTAATTATTCATGCCCTTGACCATGTGGTTGCTTGGAGACCTGGGGTCTTCTGCAGACTGAAGAAGACACA
TTTCTAGATTATTTGTCCTTTTTATCCTCTCAAAAATTTAAACACTGTACCTCTTCAGTGGTCAGAAGAAAGTTGGAAACTTTTCCTACA
TATTAGGCGTTAGTATGAGGACATTTGTTTGAATTATAGAAATTTGCCCTGAGCTGAACTGGGTTGTGTTAACACATTGGTAGAGCTATG
ATTCCTTCCCAGTTCTAAGAGATACGATCTGTAAGTCCCTATGTCACCACATTGCTTGAGATGATCATTCAGTTACTTGTCAGGATTTCT
CCTCTTCAGAGAGATTTTTTTTTATAGCACAGATTCCTTTGCCCCTTTTATCTCCTTATCTGGATATGATAAGTGGTTATGAGGGTCTCA
CTAACTATTTTGTGTTTACCTTTTATATGTGTAAAACTTTGCAGTAGCATTTAAAGTGTAATTTATTTTTCTATCAAGTGCACTATTCAT
TTAGTGTGTTCCAGTTTTATATGACTTGTATTAGAAACACTGCACTGAGTTGTTTGTACACTGAAATGAGAACTCTAGATGTAACTCTAT

>16537_16537_3_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000409727_EPB41L5_chr2_120900578_ENST00000263713_length(amino acids)=215AA_BP=15
MGLFGKTQEKPPKELEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPL
PKESLETLMLITPADSGSVLKEATDELDALLASLTENLIDHTVAPQVSSTSMITPRWIVPQSGAMSNGLAGCEMLLTGKEGHGNKDGISL

--------------------------------------------------------------
>16537_16537_4_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000409727_EPB41L5_chr2_120900578_ENST00000443902_length(transcript)=1497nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGGAGGAAGTGGTGAAGTTGA
CTGAGAAATGCCTTAATAATGTCATTGAGAGCCCAGGATTGAATGTCATGAGAGTTCCTCCTGACTTCAAGAGTAACATTTTGAAGGCTC
AAGTAGAAGCAGTGCATAAGGTTACAAAAGAAGATAGCTTATTAAGTCATAAAAATGCCAATGTTCAGGATGCTGCCACAAACAGTGCTG
TGTTAAATGAGAATAATGTGCCCCTCCCCAAAGAGTCTCTTGAGACTCTGATGCTTATCACACCTGCCGACAGTGGTTCTGTTCTAAAGG
AAGCTACAGATGAATTGGATGCCTTGCTTGCATCTCTAACTGAGAATCTAATTGATCACACAGTTGCACCTCAGGTGTCTTCCACATCCA
TGATCACACCCCGGTGGATTGTTCCGCTCTGGTCCCATTTTGGCAGAAGAAGCTGTCCTGAAGCAGAAGTGTTTACTGACCACTGAGCTC
TGAGGGCCTGTAGCTGGAATACGCATCTCTCCAGCATTCCGTCCTGGGATCCGTTTCAGCTAGAATATGTTGGATTCAGGAGCTTGTCCA
TTATTTGTAGGTAAAAAAAGCTGCACGTAGATTTGACTTCAACTCCGTAAAAAAGACAGCTGTATTTTCCGTCCAACTGGAATTGTTGAA
TCACACTGCATAGCTGCCCAAAAGAGAGTGTTTGGTCTTGAACTTTCTATACTTTTATAAATGTTACAAATTCCCGAAAGAAGGGAATTT
CTTTTTCTGGGGTTTCCTTCAAACTCTTGGCTCCACCTAGCGGTTCTATTTGTTCATAACAACTTCATAACAAGCCTGCCTCTGGTAGTC
AACAGCCTTTTGAAAGCTATTTCCATCTAGTATCAGGGTGAGAGCATCCTTGATCTGGCTGCCTGTTAGAGAAATTGCACTTTTCCTGAC
TTACCTAGAAATCAAGAATTTAGGAAATTAATGTGGACACTATAAAGGCAGACTTAGGGCCAACTTTTTTTTTTTTTTACAATTATTACA
ACACTAAAGAGAAGTTTAGAATATAGAGAGTTTTTAAATGTCTCCCATTCTTTTGATTTCTTACTGTACTGGCTATCTTAATATTTCAAG
TTTACATCAAGATAAACCCTGAGAAGAACTACGGAGAAATCAAATAAAATCCTGTCATATTTTTTTCACCCTGCCTTTCCACAGGAAGCA
CTCACAGGCACCACACACGTATCATGTAACTTATCAGTGGGGTGGGTTACTGTTGAAGAGACCCTGGGGCATTTACCTCAGGCATCTGCA
CTCCTCCGAGCCCGGTGGAGAATGCAGGCTGCTGTAGTCTCAGGTAATGAAGGCACAGCACAGCAGTACTCCACATTGTTTCCTATTTGG

>16537_16537_4_CHMP3-EPB41L5_CHMP3_chr2_86790426_ENST00000409727_EPB41L5_chr2_120900578_ENST00000443902_length(amino acids)=169AA_BP=15
MGLFGKTQEKPPKELEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAVHKVTKEDSLLSHKNANVQDAATNSAVLNENNVPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHMP3-EPB41L5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCHMP3chr2:86790426chr2:120900578ENST00000263856-16203_20715.0223.0STAMBP
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409225-15203_2070157.0STAMBP
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409727-16203_20715.0183.0STAMBP
HgeneCHMP3chr2:86790426chr2:120900578ENST00000439940-18203_2070252.0STAMBP
HgeneCHMP3chr2:86790426chr2:120900578ENST00000263856-16151_22215.0223.0VPS4A
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409225-15151_2220157.0VPS4A
HgeneCHMP3chr2:86790426chr2:120900578ENST00000409727-16151_22215.0183.0VPS4A
HgeneCHMP3chr2:86790426chr2:120900578ENST00000439940-18151_2220252.0VPS4A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHMP3-EPB41L5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHMP3-EPB41L5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource