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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHMP3-MYH9 (FusionGDB2 ID:16538)

Fusion Gene Summary for CHMP3-MYH9

Fusion gene summary

Fusion gene information	Fusion gene name: CHMP3-MYH9
	Fusion gene ID: 16538
		Hgene	Tgene
	Gene symbol	CHMP3	MYH9
	Gene ID	100526767	4627
	Gene name	RNF103-CHMP3 readthrough	myosin heavy chain 9
	Synonyms	CGI149\|CHMP3\|NEDF\|RNF103-VPS24\|VPS24\|hVps24	BDPLT6\|DFNA17\|EPSTS\|FTNS\|MATINS\|MHA\|NMHC-II-A\|NMMHC-IIA\|NMMHCA
	Cytomap	2p11.2	22q12.3
	Type of gene	protein-coding	protein-coding
	Description	RNF103-CHMP3 proteinCharged multivesicular body protein 3Chromatin-modifying protein 3Neuroendocrine differentiation factorRNF103-CHMP3 read-throughRNF103-VPS24 readthroughVacuolar protein sorting-associated protein 24	myosin-9cellular myosin heavy chain, type Amyosin, heavy chain 9, non-musclenon-muscle myosin heavy chain 9non-muscle myosin heavy chain Anon-muscle myosin heavy chain IIanon-muscle myosin heavy polypeptide 9nonmuscle myosin heavy chain II-A
	Modification date	20200313	20200315
	UniProtAcc	Q9Y3E7	P35579
	Ensembl transtripts involved in fusion gene	ENST00000263856, ENST00000409727, ENST00000409225, ENST00000439940, ENST00000494623,	ENST00000401701, ENST00000475726, ENST00000216181,
Fusion gene scores	* DoF score	10 X 6 X 6=360	44 X 46 X 15=30360
	# samples	11	56
	** MAII score	log2(11/360*10)=-1.71049338280502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/30360*10)=-5.76060115335786 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHMP3 [Title/Abstract] AND MYH9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHMP3(86790426)-MYH9(36685343), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MYH9	GO:0001525	angiogenesis	16403913
Tgene	MYH9	GO:0001778	plasma membrane repair	27325790
Tgene	MYH9	GO:0006509	membrane protein ectodomain proteolysis	16186248
Tgene	MYH9	GO:0030048	actin filament-based movement	12237319\|15845534
Tgene	MYH9	GO:0031032	actomyosin structure organization	24072716

Fusion gene breakpoints across CHMP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYH9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	2397N	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-

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Fusion Gene ORF analysis for CHMP3-MYH9

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000263856	ENST00000401701	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
5CDS-intron	ENST00000263856	ENST00000475726	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
5CDS-intron	ENST00000409727	ENST00000401701	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
5CDS-intron	ENST00000409727	ENST00000475726	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
5UTR-3CDS	ENST00000409225	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
5UTR-intron	ENST00000409225	ENST00000401701	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
5UTR-intron	ENST00000409225	ENST00000475726	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
In-frame	ENST00000263856	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
In-frame	ENST00000409727	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
intron-3CDS	ENST00000439940	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
intron-3CDS	ENST00000494623	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
intron-intron	ENST00000439940	ENST00000401701	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
intron-intron	ENST00000439940	ENST00000475726	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
intron-intron	ENST00000494623	ENST00000401701	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-
intron-intron	ENST00000494623	ENST00000475726	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263856	CHMP3	chr2	86790426	-	ENST00000216181	MYH9	chr22	36685343	-	3100	174	129	1712	527
ENST00000409727	CHMP3	chr2	86790426	-	ENST00000216181	MYH9	chr22	36685343	-	2997	71	26	1609	527

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263856	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-	0.003939566	0.99606043
ENST00000409727	ENST00000216181	CHMP3	chr2	86790426	-	MYH9	chr22	36685343	-	0.003783879	0.9962161

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Fusion Genomic Features for CHMP3-MYH9

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHMP3-MYH9

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:86790426/chr22:36685343)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHMP3 Q9Y3E7	MYH9 P35579
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells. {ECO:0000269\|PubMed:14505570, ECO:0000269\|PubMed:15707591, ECO:0000269\|PubMed:16740483, ECO:0000269\|PubMed:17331679, ECO:0000269\|PubMed:18076377}.	FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Promotes also cell motility together with S100A4 (PubMed:16707441). During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (PubMed:20052411). {ECO:0000250\|UniProtKB:Q8VDD5, ECO:0000269\|PubMed:16707441, ECO:0000269\|PubMed:20052411}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000263856

141_222

223.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000263856

22_54

223.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409225

141_222

157.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409225

22_54

157.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409727

141_222

183.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409727

22_54

183.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000439940

141_222

252.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000439940

22_54

252.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000263856

201_211

223.0

Motif

Note=MIT-interacting motif

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409225

201_211

157.0

Motif

Note=MIT-interacting motif

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409727

201_211

183.0

Motif

Note=MIT-interacting motif

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000439940

201_211

252.0

Motif

Note=MIT-interacting motif

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000263856

59_64

223.0

Region

Note=Important for autoinhibitory function

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409225

59_64

157.0

Region

Note=Important for autoinhibitory function

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000409727

59_64

183.0

Region

Note=Important for autoinhibitory function

Hgene

CHMP3

chr2:86790426

chr22:36685343

ENST00000439940

59_64

252.0

Region

Note=Important for autoinhibitory function

Tgene

MYH9

chr2:86790426

chr22:36685343

ENST00000216181

837_1926

1448

1961.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH9

chr2:86790426

chr22:36685343

ENST00000216181

27_77

1448

1961.0

Domain

Myosin N-terminal SH3-like

Tgene

MYH9

chr2:86790426

chr22:36685343

ENST00000216181

779_808

1448

1961.0

Domain

Tgene

MYH9

chr2:86790426

chr22:36685343

ENST00000216181

81_776

1448

1961.0

Domain

Myosin motor

Tgene

MYH9

chr2:86790426

chr22:36685343

ENST00000216181

174_181

1448

1961.0

Nucleotide binding

ATP

Tgene

MYH9

chr2:86790426

chr22:36685343

ENST00000216181

654_676

1448

1961.0

Region

Note=Actin-binding

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Fusion Gene Sequence for CHMP3-MYH9

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16538_16538_1_CHMP3-MYH9_CHMP3_chr2_86790426_ENST00000263856_MYH9_chr22_36685343_ENST00000216181_length(transcript)=3100nt_BP=174nt
TGCCGCCGCTCCCTACTCTGGGGGTTGGGACTACCTCCTTTTCCGCGGGCCCCGCCCAGGCGGCTGCCCGTGACCTGCCTGGGCGCGGGG
AACTGAAAGCCGGAAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGCTCCTG
GCGGAGGAGAAGACCATCTCTGCCAAGTATGCAGAGGAGCGCGACCGGGCTGAGGCGGAGGCCCGAGAGAAGGAGACCAAGGCTCTGTCG
CTGGCCCGGGCCCTGGAGGAAGCCATGGAGCAGAAGGCGGAGCTGGAGCGGCTCAACAAGCAGTTCCGCACGGAGATGGAGGACCTTATG
AGCTCCAAGGATGATGTGGGCAAGAGTGTCCACGAGCTGGAGAAGTCCAAGCGGGCCCTAGAGCAGCAGGTGGAGGAGATGAAGACGCAG
CTGGAAGAGCTGGAGGACGAGCTGCAGGCCACCGAAGATGCCAAGCTGCGGTTGGAGGTCAACCTGCAGGCCATGAAGGCCCAGTTCGAG
CGGGACCTGCAGGGCCGGGACGAGCAGAGCGAGGAGAAGAAGAAGCAGCTGGTCAGACAGGTGCGGGAGATGGAGGCAGAGCTGGAGGAC
GAGAGGAAGCAGCGCTCGATGGCAGTGGCCGCCCGGAAGAAGCTGGAGATGGACCTGAAGGACCTGGAGGCGCACATCGACTCGGCCAAC
AAGAACCGGGACGAAGCCATCAAACAGCTGCGGAAGCTGCAGGCCCAGATGAAGGACTGCATGCGCGAGCTGGATGACACCCGCGCCTCT
CGTGAGGAGATCCTGGCCCAGGCCAAAGAGAACGAGAAGAAGCTGAAGAGCATGGAGGCCGAGATGATCCAGTTGCAGGAGGAACTGGCA
GCCGCGGAGCGTGCCAAGCGCCAGGCCCAGCAGGAGCGGGATGAGCTGGCTGACGAGATCGCCAACAGCAGCGGCAAAGGAGCCCTGGCG
TTAGAGGAGAAGCGGCGTCTGGAGGCCCGCATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACACGGAGCTGATCAACGAC
CGGCTGAAGAAGGCCAACCTGCAGATCGACCAGATCAACACCGACCTGAACCTGGAGCGCAGCCACGCCCAGAAGAACGAGAATGCTCGG
CAGCAGCTGGAACGCCAGAACAAGGAGCTTAAGGTCAAGCTGCAGGAGATGGAGGGCACTGTCAAGTCCAAGTACAAGGCCTCCATCACC
GCCCTCGAGGCCAAGATTGCACAGCTGGAGGAGCAGCTGGACAACGAGACCAAGGAGCGCCAGGCAGCCTGCAAACAGGTGCGTCGGACC
GAGAAGAAGCTGAAGGATGTGCTGCTGCAGGTGGATGACGAGCGGAGGAACGCCGAGCAGTACAAGGACCAGGCCGACAAGGCATCTACC
CGCCTGAAGCAGCTCAAGCGGCAGCTGGAGGAGGCCGAAGAGGAGGCCCAGCGGGCCAACGCCTCCCGCCGGAAACTGCAGCGCGAGCTG
GAGGACGCCACTGAGACGGCCGATGCCATGAACCGCGAAGTCAGCTCCCTAAAGAACAAGCTCAGGCGCGGGGACCTGCCGTTTGTCGTG
CCCCGCCGAATGGCCCGGAAAGGCGCCGGGGATGGCTCCGACGAAGAGGTAGATGGCAAAGCGGATGGGGCTGAGGCCAAACCTGCCGAA
TAAGCCTCTTCTCCTGCAGCCTGAGATGGATGGACAGACAGACACCACAGCCTCCCCTTCCCAGACCCCGCAGCACGCCTCTCCCCACCT
TCTTGGGACTGCTGTGAACATGCCTCCTCCTGCCCTCCGCCCCGTCCCCCCATCCCGTTTCCCTCCAGGTGTTGTTGAGGGCATTTGGCT
TCCTCTGCTGCATCCCCTTCCAGCTCCCTCCCCTGCTCAGAATCTGATACCAAAGAGACAGGGCCCGGGCCCAGGCAGAGAGCGACCAGC
AGGCTCCTCAGCCCTCTCTTGCCAAAAAGCACAAGATGTTGAGGCGAGCAGGGCAGGCCCCCGGGGAGGGGCCAGAGTTTTCTATGAATC
TATTTTTCTTCAGACTGAGGCCTTTTGGTAGTCGGAGCCCCCGCAGTCGTCAGCCTCCCTGACGTCTGCCACCAGCGCCCCCACTCCTCC
TCCTTTCTTTGCTGTTTGCAATCACACGTGGTGACCTCACACACCTCTGCCCCTTGGGCCTCCCACTCCCATGGCTCTGGGCGGTCCAGA
AGGAGCAGGCCCTGGGCCTCCACCTCTGTGCAGGGCACAGAAGGCTGGGGTGGGGGGAGGAGTGGATTCCTCCCCACCCTGTCCCAGGCA
GCGCCACTGTCCGCTGTCTCCCTCCTGATTCTAAAATGTCTCAAGTGCAATGCCCCCTCCCCTCCTTTACCGAGGACAGCCTGCCTCTGC
CACAGCAAGGCTGTCGGGGTCAAGCTGGAAAGGCCAGCAGCCTTCCAGTGGCTTCTCCCAACACTCTTGGGGACCAAATATATTTAATGG
TTAAGGGACTTGTCCCAAGTCTGACAGCCAGAGCGTTAGAGGGGCCAGCGGCCCTCCCAGGCGATCTTGTGTCTACTCTAGGACTGGGCC
CGAGGGTGGTTTACCTGCACCGTTGACTCAGTATAGTTTAAAAATCTGCCACCTGCACAGGTATTTTTGAAAGCAAAATAAGGTTTTCTT
TTTTCCCCTTTCTTGTAATAAATGATAAAATTCCGAGTCTTTCTCACTGCCTTTGTTTAGAAGAGAGTAGCTCGTCCTCACTGGTCTACA
CTGGTTGCCGAATTTACTTGTATTCCTAACTGTTTTGTATATGCTGCATTGAGACTTACGGCAAGAAGGCATTTTTTTTTTTTAAAGGAA
ACAAACTCTCAAATCATGAAGTGATATAAAAGCTGCATATGCCTACAAAGCTCTGAATTCAGGTCCCAGTTGCTGTCACAAAGGAGTGAG
TGAAACTCCCACCCTACCCCCTTTTTTATATAATAAAAGTGCCTTAGCATGTGTTGCAGCTGTCACCACTACAGTAAGCTGGTTTACAGA

>16538_16538_1_CHMP3-MYH9_CHMP3_chr2_86790426_ENST00000263856_MYH9_chr22_36685343_ENST00000216181_length(amino acids)=527AA_BP=10
MGLFGKTQEKPPKELLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL
EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK
KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER
DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK
LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE

--------------------------------------------------------------
>16538_16538_2_CHMP3-MYH9_CHMP3_chr2_86790426_ENST00000409727_MYH9_chr22_36685343_ENST00000216181_length(transcript)=2997nt_BP=71nt
AAGGGGCAAGACGGGTTCAGTTCGTCATGGGGCTGTTTGGAAAGACCCAGGAGAAGCCGCCCAAAGAACTGCTCCTGGCGGAGGAGAAGA
CCATCTCTGCCAAGTATGCAGAGGAGCGCGACCGGGCTGAGGCGGAGGCCCGAGAGAAGGAGACCAAGGCTCTGTCGCTGGCCCGGGCCC
TGGAGGAAGCCATGGAGCAGAAGGCGGAGCTGGAGCGGCTCAACAAGCAGTTCCGCACGGAGATGGAGGACCTTATGAGCTCCAAGGATG
ATGTGGGCAAGAGTGTCCACGAGCTGGAGAAGTCCAAGCGGGCCCTAGAGCAGCAGGTGGAGGAGATGAAGACGCAGCTGGAAGAGCTGG
AGGACGAGCTGCAGGCCACCGAAGATGCCAAGCTGCGGTTGGAGGTCAACCTGCAGGCCATGAAGGCCCAGTTCGAGCGGGACCTGCAGG
GCCGGGACGAGCAGAGCGAGGAGAAGAAGAAGCAGCTGGTCAGACAGGTGCGGGAGATGGAGGCAGAGCTGGAGGACGAGAGGAAGCAGC
GCTCGATGGCAGTGGCCGCCCGGAAGAAGCTGGAGATGGACCTGAAGGACCTGGAGGCGCACATCGACTCGGCCAACAAGAACCGGGACG
AAGCCATCAAACAGCTGCGGAAGCTGCAGGCCCAGATGAAGGACTGCATGCGCGAGCTGGATGACACCCGCGCCTCTCGTGAGGAGATCC
TGGCCCAGGCCAAAGAGAACGAGAAGAAGCTGAAGAGCATGGAGGCCGAGATGATCCAGTTGCAGGAGGAACTGGCAGCCGCGGAGCGTG
CCAAGCGCCAGGCCCAGCAGGAGCGGGATGAGCTGGCTGACGAGATCGCCAACAGCAGCGGCAAAGGAGCCCTGGCGTTAGAGGAGAAGC
GGCGTCTGGAGGCCCGCATCGCCCAGCTGGAGGAGGAGCTGGAGGAGGAGCAGGGCAACACGGAGCTGATCAACGACCGGCTGAAGAAGG
CCAACCTGCAGATCGACCAGATCAACACCGACCTGAACCTGGAGCGCAGCCACGCCCAGAAGAACGAGAATGCTCGGCAGCAGCTGGAAC
GCCAGAACAAGGAGCTTAAGGTCAAGCTGCAGGAGATGGAGGGCACTGTCAAGTCCAAGTACAAGGCCTCCATCACCGCCCTCGAGGCCA
AGATTGCACAGCTGGAGGAGCAGCTGGACAACGAGACCAAGGAGCGCCAGGCAGCCTGCAAACAGGTGCGTCGGACCGAGAAGAAGCTGA
AGGATGTGCTGCTGCAGGTGGATGACGAGCGGAGGAACGCCGAGCAGTACAAGGACCAGGCCGACAAGGCATCTACCCGCCTGAAGCAGC
TCAAGCGGCAGCTGGAGGAGGCCGAAGAGGAGGCCCAGCGGGCCAACGCCTCCCGCCGGAAACTGCAGCGCGAGCTGGAGGACGCCACTG
AGACGGCCGATGCCATGAACCGCGAAGTCAGCTCCCTAAAGAACAAGCTCAGGCGCGGGGACCTGCCGTTTGTCGTGCCCCGCCGAATGG
CCCGGAAAGGCGCCGGGGATGGCTCCGACGAAGAGGTAGATGGCAAAGCGGATGGGGCTGAGGCCAAACCTGCCGAATAAGCCTCTTCTC
CTGCAGCCTGAGATGGATGGACAGACAGACACCACAGCCTCCCCTTCCCAGACCCCGCAGCACGCCTCTCCCCACCTTCTTGGGACTGCT
GTGAACATGCCTCCTCCTGCCCTCCGCCCCGTCCCCCCATCCCGTTTCCCTCCAGGTGTTGTTGAGGGCATTTGGCTTCCTCTGCTGCAT
CCCCTTCCAGCTCCCTCCCCTGCTCAGAATCTGATACCAAAGAGACAGGGCCCGGGCCCAGGCAGAGAGCGACCAGCAGGCTCCTCAGCC
CTCTCTTGCCAAAAAGCACAAGATGTTGAGGCGAGCAGGGCAGGCCCCCGGGGAGGGGCCAGAGTTTTCTATGAATCTATTTTTCTTCAG
ACTGAGGCCTTTTGGTAGTCGGAGCCCCCGCAGTCGTCAGCCTCCCTGACGTCTGCCACCAGCGCCCCCACTCCTCCTCCTTTCTTTGCT
GTTTGCAATCACACGTGGTGACCTCACACACCTCTGCCCCTTGGGCCTCCCACTCCCATGGCTCTGGGCGGTCCAGAAGGAGCAGGCCCT
GGGCCTCCACCTCTGTGCAGGGCACAGAAGGCTGGGGTGGGGGGAGGAGTGGATTCCTCCCCACCCTGTCCCAGGCAGCGCCACTGTCCG
CTGTCTCCCTCCTGATTCTAAAATGTCTCAAGTGCAATGCCCCCTCCCCTCCTTTACCGAGGACAGCCTGCCTCTGCCACAGCAAGGCTG
TCGGGGTCAAGCTGGAAAGGCCAGCAGCCTTCCAGTGGCTTCTCCCAACACTCTTGGGGACCAAATATATTTAATGGTTAAGGGACTTGT
CCCAAGTCTGACAGCCAGAGCGTTAGAGGGGCCAGCGGCCCTCCCAGGCGATCTTGTGTCTACTCTAGGACTGGGCCCGAGGGTGGTTTA
CCTGCACCGTTGACTCAGTATAGTTTAAAAATCTGCCACCTGCACAGGTATTTTTGAAAGCAAAATAAGGTTTTCTTTTTTCCCCTTTCT
TGTAATAAATGATAAAATTCCGAGTCTTTCTCACTGCCTTTGTTTAGAAGAGAGTAGCTCGTCCTCACTGGTCTACACTGGTTGCCGAAT
TTACTTGTATTCCTAACTGTTTTGTATATGCTGCATTGAGACTTACGGCAAGAAGGCATTTTTTTTTTTTAAAGGAAACAAACTCTCAAA
TCATGAAGTGATATAAAAGCTGCATATGCCTACAAAGCTCTGAATTCAGGTCCCAGTTGCTGTCACAAAGGAGTGAGTGAAACTCCCACC
CTACCCCCTTTTTTATATAATAAAAGTGCCTTAGCATGTGTTGCAGCTGTCACCACTACAGTAAGCTGGTTTACAGATGTTTTCCACTGA

>16538_16538_2_CHMP3-MYH9_CHMP3_chr2_86790426_ENST00000409727_MYH9_chr22_36685343_ENST00000216181_length(amino acids)=527AA_BP=10
MGLFGKTQEKPPKELLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL
EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK
KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER
DELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVK
LQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE

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Fusion Gene PPI Analysis for CHMP3-MYH9

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000263856	-	1	6	203_207	15.0	223.0	STAMBP
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000409225	-	1	5	203_207	0	157.0	STAMBP
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000409727	-	1	6	203_207	15.0	183.0	STAMBP
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000439940	-	1	8	203_207	0	252.0	STAMBP
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000263856	-	1	6	151_222	15.0	223.0	VPS4A
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000409225	-	1	5	151_222	0	157.0	VPS4A
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000409727	-	1	6	151_222	15.0	183.0	VPS4A
Hgene	CHMP3	chr2:86790426	chr22:36685343	ENST00000439940	-	1	8	151_222	0	252.0	VPS4A

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CHMP3-MYH9

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CHMP3-MYH9

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source