FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CHMP4A-MRPL52 (FusionGDB2 ID:16548)

Fusion Gene Summary for CHMP4A-MRPL52

check button Fusion gene summary
Fusion gene informationFusion gene name: CHMP4A-MRPL52
Fusion gene ID: 16548
HgeneTgene
Gene symbol

CHMP4A

MRPL52

Gene ID

128866

122704

Gene namecharged multivesicular body protein 4Bmitochondrial ribosomal protein L52
SynonymsC20orf178|CHMP4A|CTPP3|CTRCT31|SNF7|SNF7-2|Shax1|VPS32B|Vps32-2|dJ553F4.4-
Cytomap

20q11.22

14q11.2

Type of geneprotein-codingprotein-coding
Descriptioncharged multivesicular body protein 4bSNF7 homolog associated with Alix 1Snf7 homologue associated with Alix 1chromatin modifying protein 4Bchromatin-modifying protein 4bhSnf7-2hVps32-2vacuolar protein-sorting-associated protein 32-239S ribosomal protein L52, mitochondrialL52mtMRP-L52mitochondrial large ribosomal subunit protein mL52
Modification date2020031320200313
UniProtAcc

Q9BY43

Q86TS9

Ensembl transtripts involved in fusion geneENST00000347519, ENST00000609024, 
ENST00000530996, ENST00000542700, 
ENST00000461594, ENST00000555536, 
ENST00000311892, ENST00000355151, 
ENST00000397496, ENST00000397505, 
ENST00000432849, ENST00000553711, 
ENST00000555345, ENST00000556840, 
ENST00000557221, 
Fusion gene scores* DoF score4 X 3 X 2=246 X 4 X 5=120
# samples 46
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHMP4A [Title/Abstract] AND MRPL52 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHMP4A(24682614)-MRPL52(23303380), # samples:1
Anticipated loss of major functional domain due to fusion event.CHMP4A-MRPL52 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CHMP4A-MRPL52 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHMP4A

GO:0039702

viral budding via host ESCRT complex

24878737

HgeneCHMP4A

GO:0051258

protein polymerization

18209100


check buttonFusion gene breakpoints across CHMP4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MRPL52 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-2019CHMP4Achr14

24682614

-MRPL52chr14

23303380

+


Top

Fusion Gene ORF analysis for CHMP4A-MRPL52

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000347519ENST00000461594CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5CDS-intronENST00000347519ENST00000555536CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5CDS-intronENST00000609024ENST00000461594CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5CDS-intronENST00000609024ENST00000555536CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000311892CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000355151CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000397496CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000397505CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000432849CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000553711CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000555345CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000556840CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-3CDSENST00000530996ENST00000557221CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-intronENST00000530996ENST00000461594CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
5UTR-intronENST00000530996ENST00000555536CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000347519ENST00000311892CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000347519ENST00000355151CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000347519ENST00000397496CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000347519ENST00000432849CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000347519ENST00000556840CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000609024ENST00000311892CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000609024ENST00000355151CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000609024ENST00000397496CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000609024ENST00000432849CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
Frame-shiftENST00000609024ENST00000556840CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000347519ENST00000397505CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000347519ENST00000553711CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000347519ENST00000555345CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000347519ENST00000557221CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000609024ENST00000397505CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000609024ENST00000553711CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000609024ENST00000555345CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
In-frameENST00000609024ENST00000557221CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000311892CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000355151CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000397496CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000397505CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000432849CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000553711CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000555345CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000556840CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-3CDSENST00000542700ENST00000557221CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-intronENST00000542700ENST00000461594CHMP4Achr14

24682614

-MRPL52chr14

23303380

+
intron-intronENST00000542700ENST00000555536CHMP4Achr14

24682614

-MRPL52chr14

23303380

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000347519CHMP4Achr1424682614-ENST00000555345MRPL52chr1423303380+100746157364169
ENST00000347519CHMP4Achr1424682614-ENST00000553711MRPL52chr1423303380+63546157364169
ENST00000347519CHMP4Achr1424682614-ENST00000397505MRPL52chr1423303380+63746157364169
ENST00000347519CHMP4Achr1424682614-ENST00000557221MRPL52chr1423303380+111846157364169
ENST00000609024CHMP4Achr1424682614-ENST00000555345MRPL52chr1423303380+62680620666
ENST00000609024CHMP4Achr1424682614-ENST00000553711MRPL52chr1423303380+25480620666
ENST00000609024CHMP4Achr1424682614-ENST00000397505MRPL52chr1423303380+25680620666
ENST00000609024CHMP4Achr1424682614-ENST00000557221MRPL52chr1423303380+73780620666

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000347519ENST00000555345CHMP4Achr1424682614-MRPL52chr1423303380+0.876791060.12320894
ENST00000347519ENST00000553711CHMP4Achr1424682614-MRPL52chr1423303380+0.63606430.36393574
ENST00000347519ENST00000397505CHMP4Achr1424682614-MRPL52chr1423303380+0.629304650.3706954
ENST00000347519ENST00000557221CHMP4Achr1424682614-MRPL52chr1423303380+0.85337870.14662127
ENST00000609024ENST00000555345CHMP4Achr1424682614-MRPL52chr1423303380+0.74063630.2593637
ENST00000609024ENST00000553711CHMP4Achr1424682614-MRPL52chr1423303380+0.277240960.722759
ENST00000609024ENST00000397505CHMP4Achr1424682614-MRPL52chr1423303380+0.264841620.7351583
ENST00000609024ENST00000557221CHMP4Achr1424682614-MRPL52chr1423303380+0.748343940.251656

Top

Fusion Genomic Features for CHMP4A-MRPL52


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHMP4Achr1424682614-MRPL52chr1423303380+0.0358763560.9641236
CHMP4Achr1424682614-MRPL52chr1423303380+0.0358763560.9641236

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CHMP4A-MRPL52


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:24682614/chr14:23303380)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHMP4A

Q9BY43

MRPL52

Q86TS9

FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:12860994, ECO:0000269|PubMed:14505569, ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:18209100, ECO:0000269|PubMed:22660413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHMP4Achr14:24682614chr14:23303380ENST00000347519-16155_18053266.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP4Achr14:24682614chr14:23303380ENST00000347519-1620_10553266.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP4Achr14:24682614chr14:23303380ENST00000609024-16155_18010223.0Coiled coilOntology_term=ECO:0000255
HgeneCHMP4Achr14:24682614chr14:23303380ENST00000609024-1620_10510223.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for CHMP4A-MRPL52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16548_16548_1_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000397505_length(transcript)=637nt_BP=461nt
ATGTGAGACATTAGACTGCATCAGGTTTGCCATCTAAACTTAGGGCAACCCCAAGTGCTTGAACCTATACCACCCCACTTTCCTGAGCTC
TGTAAAGAGCATGAAGTTTTCCCACTGACCCCATACACTGAGGTGCCATCACACTGCACATTTCCTTCCGGAGAACAAGCACGTACTCAG
GTGGAGATAGAACTGTCTTTTTACTTAATAGAAAATGATGTGGCAGCTTTAAGAGGAGCGCGTCGGTCTGGGGCTGGTGGCTTGGGTCAC
GTGACACCGGTGGTCTCGTTTGCGCCTCTTGATGTCGCGGCGGCGCCCTGAGGACGGATTGGGCAAGGCTGGTCCCTGTGTGATGAGACA
TCACCCTCCCAGGAGCAAGGCGGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCT
CTTCGGGAAGGAGACGAGTTGTACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAG
AACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCC

>16548_16548_1_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000397505_length(amino acids)=169AA_BP=1
MGLRAFSCFLCSSCNFCCLSCHACNPASISCDSSTTRLLPEEPAETTHRELASPASAPQRPPDFRLAPGRVMSHHTGTSLAQSVLRAPPR

--------------------------------------------------------------
>16548_16548_2_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000553711_length(transcript)=635nt_BP=461nt
ATGTGAGACATTAGACTGCATCAGGTTTGCCATCTAAACTTAGGGCAACCCCAAGTGCTTGAACCTATACCACCCCACTTTCCTGAGCTC
TGTAAAGAGCATGAAGTTTTCCCACTGACCCCATACACTGAGGTGCCATCACACTGCACATTTCCTTCCGGAGAACAAGCACGTACTCAG
GTGGAGATAGAACTGTCTTTTTACTTAATAGAAAATGATGTGGCAGCTTTAAGAGGAGCGCGTCGGTCTGGGGCTGGTGGCTTGGGTCAC
GTGACACCGGTGGTCTCGTTTGCGCCTCTTGATGTCGCGGCGGCGCCCTGAGGACGGATTGGGCAAGGCTGGTCCCTGTGTGATGAGACA
TCACCCTCCCAGGAGCAAGGCGGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCT
CTTCGGGAAGGAGACGAGTTGTACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAG
AACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCC

>16548_16548_2_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000553711_length(amino acids)=169AA_BP=1
MGLRAFSCFLCSSCNFCCLSCHACNPASISCDSSTTRLLPEEPAETTHRELASPASAPQRPPDFRLAPGRVMSHHTGTSLAQSVLRAPPR

--------------------------------------------------------------
>16548_16548_3_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000555345_length(transcript)=1007nt_BP=461nt
ATGTGAGACATTAGACTGCATCAGGTTTGCCATCTAAACTTAGGGCAACCCCAAGTGCTTGAACCTATACCACCCCACTTTCCTGAGCTC
TGTAAAGAGCATGAAGTTTTCCCACTGACCCCATACACTGAGGTGCCATCACACTGCACATTTCCTTCCGGAGAACAAGCACGTACTCAG
GTGGAGATAGAACTGTCTTTTTACTTAATAGAAAATGATGTGGCAGCTTTAAGAGGAGCGCGTCGGTCTGGGGCTGGTGGCTTGGGTCAC
GTGACACCGGTGGTCTCGTTTGCGCCTCTTGATGTCGCGGCGGCGCCCTGAGGACGGATTGGGCAAGGCTGGTCCCTGTGTGATGAGACA
TCACCCTCCCAGGAGCAAGGCGGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCT
CTTCGGGAAGGAGACGAGTTGTACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAG
AACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCC
TTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGA
GAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTC
AGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCA
GATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATT

>16548_16548_3_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000555345_length(amino acids)=169AA_BP=1
MGLRAFSCFLCSSCNFCCLSCHACNPASISCDSSTTRLLPEEPAETTHRELASPASAPQRPPDFRLAPGRVMSHHTGTSLAQSVLRAPPR

--------------------------------------------------------------
>16548_16548_4_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000557221_length(transcript)=1118nt_BP=461nt
ATGTGAGACATTAGACTGCATCAGGTTTGCCATCTAAACTTAGGGCAACCCCAAGTGCTTGAACCTATACCACCCCACTTTCCTGAGCTC
TGTAAAGAGCATGAAGTTTTCCCACTGACCCCATACACTGAGGTGCCATCACACTGCACATTTCCTTCCGGAGAACAAGCACGTACTCAG
GTGGAGATAGAACTGTCTTTTTACTTAATAGAAAATGATGTGGCAGCTTTAAGAGGAGCGCGTCGGTCTGGGGCTGGTGGCTTGGGTCAC
GTGACACCGGTGGTCTCGTTTGCGCCTCTTGATGTCGCGGCGGCGCCCTGAGGACGGATTGGGCAAGGCTGGTCCCTGTGTGATGAGACA
TCACCCTCCCAGGAGCAAGGCGGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCT
CTTCGGGAAGGAGACGAGTTGTACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAG
AACAAAGGAAGCAGGAAAATGCTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCC
TTCCTCACCCTGTCTCTGGATTTCTTTTCTATCACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGA
GAAAAAGAGCTGGGACACCAAGAACAAGCTGTTAGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTC
AGCTAAGTCTTGCTTTAAAATTTTTACCTCCTAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCA
GATCACAAGATCAGGAGTTCGAGACCAGCCTGGCCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATT
AGCCGGGCGTGGTGGGGTGCGCTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAG

>16548_16548_4_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000347519_MRPL52_chr14_23303380_ENST00000557221_length(amino acids)=169AA_BP=1
MGLRAFSCFLCSSCNFCCLSCHACNPASISCDSSTTRLLPEEPAETTHRELASPASAPQRPPDFRLAPGRVMSHHTGTSLAQSVLRAPPR

--------------------------------------------------------------
>16548_16548_5_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000397505_length(transcript)=256nt_BP=80nt
GGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGAGACGAGTTG
TACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATG

>16548_16548_5_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000397505_length(amino acids)=66AA_BP=20

--------------------------------------------------------------
>16548_16548_6_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000553711_length(transcript)=254nt_BP=80nt
GGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGAGACGAGTTG
TACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATG

>16548_16548_6_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000553711_length(amino acids)=66AA_BP=20

--------------------------------------------------------------
>16548_16548_7_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000555345_length(transcript)=626nt_BP=80nt
GGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGAGACGAGTTG
TACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATG
CTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGAT
TTCTTTTCTATCACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAA
GAACAAGCTGTTAGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAAT
TTTTACCTCCTAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCG

>16548_16548_7_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000555345_length(amino acids)=66AA_BP=20

--------------------------------------------------------------
>16548_16548_8_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000557221_length(transcript)=737nt_BP=80nt
GGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGAGCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGAGACGAGTTG
TACTGCTGTCACAGGAAATGGACGCTGGATTACAAGCATGGCAGCTCAGGCAGCAGAAGTTGCAGGAAGAACAAAGGAAGCAGGAAAATG
CTCTTAAACCCAAAGGGGCTTCACTGAAGAGCCCACTTCCAAGTCAATAAAAAGCAACTCCTGCCTCCCTTCCTCACCCTGTCTCTGGAT
TTCTTTTCTATCACCTAGATGCTTCATCCAGCCAGAAGATAGCCTTCACGTTCCCCATCTGTCTTCAGAGAAAAAGAGCTGGGACACCAA
GAACAAGCTGTTAGATCACTGCCTGGGAGGCTTGGCTTAGTACTCTCATCTCTGGTTCCATTCCAGTTCAGCTAAGTCTTGCTTTAAAAT
TTTTACCTCCTAGCTGGGTGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAGATCACAAGATCAGGAGTTCG
AGACCAGCCTGGCCAACCCAGCCTGGTCAACATGGTGAAACCCTGTCCCTACTAAAGATACAAACAATTAGCCGGGCGTGGTGGGGTGCG
CTTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTAAACTCGGGAGGTAGAGGTTGCAGTGAGCCAAGGTCACACCATTG

>16548_16548_8_CHMP4A-MRPL52_CHMP4A_chr14_24682614_ENST00000609024_MRPL52_chr14_23303380_ENST00000557221_length(amino acids)=66AA_BP=20

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CHMP4A-MRPL52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCHMP4Achr14:24682614chr14:23303380ENST00000347519-161_11653.333333333333336266.0phosphoinosides
HgeneCHMP4Achr14:24682614chr14:23303380ENST00000609024-161_11610.333333333333334223.0phosphoinosides


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CHMP4A-MRPL52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CHMP4A-MRPL52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource