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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHN2-SKAP2 (FusionGDB2 ID:16583)

Fusion Gene Summary for CHN2-SKAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: CHN2-SKAP2
Fusion gene ID: 16583
HgeneTgene
Gene symbol

CHN2

SKAP2

Gene ID

4359

8935

Gene namemyelin protein zerosrc kinase associated phosphoprotein 2
SynonymsCHM|CHN2|CMT1|CMT1B|CMT2I|CMT2J|CMT4E|CMTDI3|CMTDID|DSS|HMSNIB|MPP|P0PRAP|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R
Cytomap

1q23.3

7p15.2

Type of geneprotein-codingprotein-coding
Descriptionmyelin protein P0Charcot-Marie-Tooth neuropathy 1Bmyelin peripheral proteinsrc kinase-associated phosphoprotein 2Fyn-associated phosphoprotein SKAP55 homologuePyk2/RAFTK-associated proteinSKAP-55HOMSKAP55 homologretinoic acid-induced protein 70src family-associated phosphoprotein 2src kinase-associated phosphoprotein of 5
Modification date2020032820200313
UniProtAcc

P52757

.
Ensembl transtripts involved in fusion geneENST00000222792, ENST00000435288, 
ENST00000495789, ENST00000539389, 
ENST00000409041, ENST00000410098, 
ENST00000421775, ENST00000424025, 
ENST00000439711, ENST00000539406, 
ENST00000546235, 		ENST00000489977, 
ENST00000539623, ENST00000345317, 
Fusion gene scores* DoF score6 X 5 X 5=15010 X 9 X 7=630
# samples 813
** MAII scorelog2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/630*10)=-2.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHN2 [Title/Abstract] AND SKAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHN2(29234606)-SKAP2(26779583), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CHN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-31-1956-01ACHN2chr7

29234606

+SKAP2chr7

26779583

-
ChimerDB4OVTCGA-31-1956CHN2chr7

29234606

+SKAP2chr7

26779583

-


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Fusion Gene ORF analysis for CHN2-SKAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000222792ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000222792ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000435288ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000435288ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000495789ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000495789ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000539389ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
5CDS-5UTRENST00000539389ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
In-frameENST00000222792ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
In-frameENST00000435288ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
In-frameENST00000495789ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
In-frameENST00000539389ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000409041ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000410098ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000421775ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000424025ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000439711ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000539406ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-3CDSENST00000546235ENST00000345317CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000409041ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000409041ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000410098ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000410098ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000421775ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000421775ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000424025ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000424025ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000439711ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000439711ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000539406ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000539406ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000546235ENST00000489977CHN2chr7

29234606

+SKAP2chr7

26779583

-
intron-5UTRENST00000546235ENST00000539623CHN2chr7

29234606

+SKAP2chr7

26779583

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222792CHN2chr729234606+ENST00000345317SKAP2chr726779583-39565794341351305
ENST00000435288CHN2chr729234606+ENST00000345317SKAP2chr726779583-38634863411258305
ENST00000495789CHN2chr729234606+ENST00000345317SKAP2chr726779583-34436617838273
ENST00000539389CHN2chr729234606+ENST00000345317SKAP2chr726779583-3426490821273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222792ENST00000345317CHN2chr729234606+SKAP2chr726779583-0.0002440680.9997559
ENST00000435288ENST00000345317CHN2chr729234606+SKAP2chr726779583-0.0002493890.99975055
ENST00000495789ENST00000345317CHN2chr729234606+SKAP2chr726779583-0.000189180.9998109
ENST00000539389ENST00000345317CHN2chr729234606+SKAP2chr726779583-0.000187580.9998124

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Fusion Genomic Features for CHN2-SKAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHN2-SKAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:29234606/chr7:26779583)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHN2

P52757

.
FUNCTION: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSKAP2chr7:29234606chr7:26779583ENST00000345317313116_2191021096.6666666666667DomainPH
TgeneSKAP2chr7:29234606chr7:26779583ENST00000345317313297_3581021096.6666666666667DomainSH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHN2chr7:29234606chr7:26779583ENST00000222792+113277_46816469.0DomainRho-GAP
HgeneCHN2chr7:29234606chr7:26779583ENST00000222792+11359_12716469.0DomainSH2
HgeneCHN2chr7:29234606chr7:26779583ENST00000409041+17277_4680333.0DomainRho-GAP
HgeneCHN2chr7:29234606chr7:26779583ENST00000409041+1759_1270333.0DomainSH2
HgeneCHN2chr7:29234606chr7:26779583ENST00000421775+16277_4680275.0DomainRho-GAP
HgeneCHN2chr7:29234606chr7:26779583ENST00000421775+1659_1270275.0DomainSH2
HgeneCHN2chr7:29234606chr7:26779583ENST00000424025+17277_4680288.0DomainRho-GAP
HgeneCHN2chr7:29234606chr7:26779583ENST00000424025+1759_1270288.0DomainSH2
HgeneCHN2chr7:29234606chr7:26779583ENST00000439711+16277_4680287.0DomainRho-GAP
HgeneCHN2chr7:29234606chr7:26779583ENST00000439711+1659_1270287.0DomainSH2
HgeneCHN2chr7:29234606chr7:26779583ENST00000539389+110277_46816325.0DomainRho-GAP
HgeneCHN2chr7:29234606chr7:26779583ENST00000539389+11059_12716325.0DomainSH2
HgeneCHN2chr7:29234606chr7:26779583ENST00000222792+113214_26416469.0Zinc fingerPhorbol-ester/DAG-type
HgeneCHN2chr7:29234606chr7:26779583ENST00000409041+17214_2640333.0Zinc fingerPhorbol-ester/DAG-type
HgeneCHN2chr7:29234606chr7:26779583ENST00000421775+16214_2640275.0Zinc fingerPhorbol-ester/DAG-type
HgeneCHN2chr7:29234606chr7:26779583ENST00000424025+17214_2640288.0Zinc fingerPhorbol-ester/DAG-type
HgeneCHN2chr7:29234606chr7:26779583ENST00000439711+16214_2640287.0Zinc fingerPhorbol-ester/DAG-type
HgeneCHN2chr7:29234606chr7:26779583ENST00000539389+110214_26416325.0Zinc fingerPhorbol-ester/DAG-type
TgeneSKAP2chr7:29234606chr7:26779583ENST0000034531731314_641021096.6666666666667RegionHomodimerization


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Fusion Gene Sequence for CHN2-SKAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16583_16583_1_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000222792_SKAP2_chr7_26779583_ENST00000345317_length(transcript)=3956nt_BP=579nt
TTCTTCCTTTGTGTGTGCGCGAGCGGAGTTGGGGCGGAGGGAGAAGGGGGAGGTCGCTCTGTCTGTCCGTCTCCCGCCGCCTCTGCCCGG
TCTACTCGAAGTGCGGCGGGAGAGGCGGGAGCCCAGGAGAGGGTGCGGGAGCTGGCGGGGCGGCTCGGAGCTGCCAGGACGCCCTGGTCC
CAGCCGCGCACAGGGGAGCGTGGACGGCAGAGGGGCTCGGCGGGAGCCGAGATCCGCCCGTCCCGGCTGCCCCTCGGCCTCCCTCTGCTC
CCACCTACCCCCTGACACCCATAGAAAAGCGTGCAAAGGCGCGGAGCGGGACGGAAACCACAAATAAATAGCGGCGGCGGCAGCGCGTCA
TCTGGTGGAGCAGGAAGTGCAGGCAGAGTCCGGAGGCTGGTGCTTTCTGCGCGTCCCCAGGACTTTGCCATGGGCTGGGGGCCGCGGAGG
CTGCGAGCGGCCGGGCGAGGGCAGCGGCGGCGGCGTCCGCACCGGGGCTGAGCGAGCAGCGACGCGAGGGGCGCGCGGAGATGGCAGCGT
CCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGTTCTAAAGG
CTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAACGGTATTCT
ATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCTAAGAAAGG
ATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGCTGAAGAAT
GGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATATGATGATG
TTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGAAGAAGAGG
ACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGCTA
ATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGG
AATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATATTT
GAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACC
TCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAA
GGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGA
TTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGT
AATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTT
TTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTT
TCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGT
GCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTT
TGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACAT
GGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTG
CTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAA
AAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATT
TACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGT
AGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAG
ATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATA
TGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGG
AACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTT
TATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTT
GATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTT
TTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAAC
TTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTT
TAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGG
AAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGT
CTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGG
AGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATTTG
ATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCATTA
ATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGA
ACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGT

>16583_16583_1_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000222792_SKAP2_chr7_26779583_ENST00000345317_length(amino acids)=305AA_BP=48
MGAAEAASGRARAAAAASAPGLSEQRREGRAEMAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCAL
SKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERG
ELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVI

--------------------------------------------------------------
>16583_16583_2_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000435288_SKAP2_chr7_26779583_ENST00000345317_length(transcript)=3863nt_BP=486nt
ACTCGAAGTGCGGCGGGAGAGGCGGGAGCCCAGGAGAGGGTGCGGGAGCTGGCGGGGCGGCTCGGAGCTGCCAGGACGCCCTGGTCCCAG
CCGCGCACAGGGGAGCGTGGACGGCAGAGGGGCTCGGCGGGAGCCGAGATCCGCCCGTCCCGGCTGCCCCTCGGCCTCCCTCTGCTCCCA
CCTACCCCCTGACACCCATAGAAAAGCGTGCAAAGGCGCGGAGCGGGACGGAAACCACAAATAAATAGCGGCGGCGGCAGCGCGTCATCT
GGTGGAGCAGGAAGTGCAGGCAGAGTCCGGAGGCTGGTGCTTTCTGCGCGTCCCCAGGACTTTGCCATGGGCTGGGGGCCGCGGAGGCTG
CGAGCGGCCGGGCGAGGGCAGCGGCGGCGGCGTCCGCACCGGGGCTGAGCGAGCAGCGACGCGAGGGGCGCGCGGAGATGGCAGCGTCCA
GCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTTGTTCTAAAGGCTG
GCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAAACGGTATTCTATT
ATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACTCTAAGAAAGGATG
GAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGATGCTGAAGAATGGG
TACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTATATGATGATGTTG
ATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAAGAAGAAGAGGACA
GTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACTGATTATGCTAATT
TTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATTCTTAGCAAGGAAT
ACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATGTATGATATTTGAG
AGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACAGCTCCTAACCTCT
CCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAAATTAAATGAAGGA
TATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTTACCCATTTGATTT
GTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGGTGTGATTTGTAAT
GTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCATGCGAGTTTTTTTT
GGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTATTATTTATTTTCA
CACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTGCAACAGAAGTGCG
TACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCTACTGTACTTTTGT
TTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCCAGGCCAACATGGT
GAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGCACGAGAATTGCTT
GAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCATCTCAGAAAAAAA
AAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTGCTATACTATTTAC
ATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAGAGGAGAGTGTAGA
AATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTGCCTGAGCAAGATT
TGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAGCCTTAACATATGT
CAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATTATCTTTATGGAAC
TTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTGTAAAACTGTTTAT
AAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAAAAAGAAATTTGAT
TTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAGTTCTTACCTTTTC
CTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGGTTTTCAAAACTTG
AGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAAAAGAAGTTTTTAG
TCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCGCCCATGATGGAAA
GCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAAGCCAGATAGTCTC
GTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAATATAGGTGGGAGA
CATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTATATTCATTTGATG
AAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAATAATATCATTAATA
TAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGTTTTTCTGTGAACA
GTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTACTGAATTTGTACT

>16583_16583_2_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000435288_SKAP2_chr7_26779583_ENST00000345317_length(amino acids)=305AA_BP=48
MGAAEAASGRARAAAAASAPGLSEQRREGRAEMAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCAL
SKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERG
ELYDDVDHPLPISNPLTSSQPIDDEIYEELPEEEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVI

--------------------------------------------------------------
>16583_16583_3_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000495789_SKAP2_chr7_26779583_ENST00000345317_length(transcript)=3443nt_BP=66nt
GCGAGGGGCGCGCGGAGATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAG
CACAAGACCTTCCTTTTGTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGT
GGTGTGCTCTCAGTAAAACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTG
TCAGAATGAATAACACTCTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAG
CAGCTTCTCCCAAAGATGCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATG
ATGAGAGAGGAGAATTATATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTT
ATGAAGAACTTCCAGAAGAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCT
CAGGGGATAAGAGCACTGATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTG
GTGATGTGATTTACATTCTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAG
CCTACATAATGGAGATGTATGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCA
TGAAAGCACGAGTGACAGCTCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAA
TATTCCTCTGATGTGAAATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAAT
AATTATAGTTTTTATTTACCCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCT
ACTATTGCTACTTCTGGTGTGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTT
TAAATTTAGTGTATCATGCGAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTAT
AGATAACTTTATTGTTATTATTTATTTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGG
CAGTGTGCTGTCACCTGCAACAGAAGTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGG
GCCTGGCAACATTTTCTACTGTACTTTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTA
TAAAGAATCTCCCAGCCAGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCT
ACTTGGGAGGCCAAGGCACGAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGC
GACAGAGTGAGACTCCATCTCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCT
CTTATCTTGCCTTATTGCTATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAG
AAAGGAAGGGTTTGCAGAGGAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTG
AGTTATACTCTGTGCTGCCTGAGCAAGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCT
ATGAGATACCAATGTAGCCTTAACATATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATC
ATTACCTATCAGGTATTATCTTTATGGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAA
AATCTCCATTATTTGTGTAAAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATC
TCAAATGTGAAAAAAAAAAAGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAG
AAGTTACATTTGTGCAGTTCTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGA
CGACTTTAGTGGACTGGTTTTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGT
TTGTGCTTTGGGTTGAAAAGAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCC
CCCATGGCACAAACTCGCCCATGATGGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTG
ATGACCAACAGTTCCAAGCCAGATAGTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTG
TTCTTTTAAAACTTGAATATAGGTGGGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTC
AATTCATGACTGCTTTATATTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATA
CTCTTCAAGATCATAATAATATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTT
GCTTAGCTTTTATTTGTTTTTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCT
TGATTATTTGCTCTGTACTGAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCAAATTTTTAAGGTTCAAATAAA

>16583_16583_3_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000495789_SKAP2_chr7_26779583_ENST00000345317_length(amino acids)=273AA_BP=16
MAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT
LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPE
EEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM

--------------------------------------------------------------
>16583_16583_4_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000539389_SKAP2_chr7_26779583_ENST00000345317_length(transcript)=3426nt_BP=49nt
ATGGCAGCGTCCAGCAACTCCAGCCTGTCCGGCTCGTCGGTGTCCTCCGGAGCCCAGTTTCCTCCAATTGCAGCACAAGACCTTCCTTTT
GTTCTAAAGGCTGGCTACCTTGAAAAACGCAGAAAAGATCACAGCTTTCTGGGATTTGAATGGCAGAAACGGTGGTGTGCTCTCAGTAAA
ACGGTATTCTATTATTATGGAAGTGATAAAGACAAACAACAGAAAGGTGAATTTGCAATAGATGGCTACAGTGTCAGAATGAATAACACT
CTAAGAAAGGATGGAAAGAAAGATTGCTGTTTTGAAATCTCTGCTCCTGATAAACGTATATATCAGTTTACAGCAGCTTCTCCCAAAGAT
GCTGAAGAATGGGTACAGCAGCTGAAATTTGTATTGCAAGATATGGAATCTGATATTATTCCTGAGGATTATGATGAGAGAGGAGAATTA
TATGATGATGTTGATCATCCTCTACCAATAAGCAATCCACTAACAAGCAGTCAACCAATAGATGATGAAATTTATGAAGAACTTCCAGAA
GAAGAAGAGGACAGTGCTCCAGTGAAAGTGGAAGAACAAAGGAAGATGAGTCAGGATAGTGTCCATCACACCTCAGGGGATAAGAGCACT
GATTATGCTAATTTTTACCAGGGATTGTGGGATTGTACTGGAGCTTTTTCTGATGAGTTGTCATTTAAGCGTGGTGATGTGATTTACATT
CTTAGCAAGGAATACAATAGATATGGCTGGTGGGTAGGAGAAATGAAGGGAGCCATTGGCTTGGTGCCTAAAGCCTACATAATGGAGATG
TATGATATTTGAGAGTCCTGGAAAAGGAAAATTCTTCTGCTTGTCTGCAAATGCTTTGGATTTAGAAGCGTCATGAAAGCACGAGTGACA
GCTCCTAACCTCTCCTTGTTTTATTAAACATTACTTATCTTTGACTGTTATTTTATGCAGTCGCTCATTAAAATATTCCTCTGATGTGAA
ATTAAATGAAGGATATTAATGTAAATTAGATGCAACCAGTTAAGTTATACCTGTTGCTATTTTGCAAAGAAATAATTATAGTTTTTATTT
ACCCATTTGATTTGTGTGAAGAATTCATCACTATTTTATACGTAACATATAGTCTACTATAGCATAGTATGCTACTATTGCTACTTCTGG
TGTGATTTGTAATGTTTCTTAATCATTGGACATCAATTATTTTTAGAGAGTAATGTATAATTTCATAGCATTTTAAATTTAGTGTATCAT
GCGAGTTTTTTTTGGTAGATGCTGAAGAATGTGGTTGCTAAACAAAGAATGCTAAAGAATGTTCAAACTTTATAGATAACTTTATTGTTA
TTATTTATTTTCACACATTTAATTCCTATTAAGTACAGCCGCAAGAAAGAAAAAATGATGAAGTTGCAAATGGCAGTGTGCTGTCACCTG
CAACAGAAGTGCGTACCAGAAGTATGACTCATGCAAAGCATTTTACCGTACAAATATCCTGGTGCGATGATGGGCCTGGCAACATTTTCT
ACTGTACTTTTGTTTAAATTTAATGAAACAAAAAATTCCTAAGAAATACCACCCTACCACTAACAAAATGGTATAAAGAATCTCCCAGCC
AGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATTAGCCAAGTGTGGTAATGTTCACCTGCAGTCCCAGCTACTTGGGAGGCCAAGGC
ACGAGAATTGCTTGAACAAGGTAGGCAGAGGTTGCAGTGAGCCAAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGTGAGACTCCA
TCTCAGAAAAAAAAAAAAAAAAAAACAGAATCTCAGTGTATTCTCAAAGTAAAAAGGCATAACCAAGCACTCTCTTATCTTGCCTTATTG
CTATACTATTTACATCCCACTGCAGAACAGCAGATTTGAGGCTTTTCTATATACTTCTCAGAGCACTGAAAAGAAAGGAAGGGTTTGCAG
AGGAGAGTGTAGAAATCCCAGTGGTAGCATGTACCAACAGGTGAGTAGAAAGGTAGTGTTAGCCTGACATTTGAGTTATACTCTGTGCTG
CCTGAGCAAGATTTGTAGAATCATATAATTACCTTTTCATGTATATTTGAAATCAGAGGTGTTTAAAATACCTATGAGATACCAATGTAG
CCTTAACATATGTCAAAATGCATTGCTGGTTAGATAATTATTTGGACTACACATAAACTCCTAATATTGAATCATTACCTATCAGGTATT
ATCTTTATGGAACTTTTCAATATCTTTGCTTTATAAAGATTCTAAACATGTATCTGAGCTGGTAATATTTTAAAATCTCCATTATTTGTG
TAAAACTGTTTATAAGCAGTGTTTGAGAGGGTCTGCTTTACCATTACCCCCTCAATATCATGATCATCCAATCTCAAATGTGAAAAAAAA
AAAGAAATTTGATTTTAGGGATTGTGAGTAAACAAGTTTATATAGAGAGACATTGTGAAGTTAAAGTTTTCAGAAGTTACATTTGTGCAG
TTCTTACCTTTTCCTCATATAGTGCCATTGAAATAGACTGAAATTATCTTGGCAAAAGTTAGACAACCAAAGACGACTTTAGTGGACTGG
TTTTCAAAACTTGAGCAGCTGAAAAGCAAAAGCCGTTGTTTCCCATGACAATGTAGCCTTTGTGGATTTGGGTTTGTGCTTTGGGTTGAA
AAGAAGTTTTTAGTCCTAGGCCAGTAGATGGCAGCAGCTTTTCATTGCAGACAAAACCTCTTGAAACCCTTCCCCCATGGCACAAACTCG
CCCATGATGGAAAGCATCTAGATTTCTGCCTCCTTTTACAGTTAATCCAGGAGAGGGAGTCCTTTGCCAACTGATGACCAACAGTTCCAA
GCCAGATAGTCTCGTGAACAGTGACAATACAGAAATAAGGTGTTATTTCTGTTCAGATCTCCACCGGCCTTTGTTCTTTTAAAACTTGAA
TATAGGTGGGAGACATAAGAAAGGAAAGAAAAGACTTAAAACTGGAGTGACAGGACAAATAATCATTACTTTCAATTCATGACTGCTTTA
TATTCATTTGATGAAATCATTTGTATACAAACCAGGGAGAGTTTTCTTTACACCCTTGACAATATATCACATACTCTTCAAGATCATAAT
AATATCATTAATATAAATTTAAACAACATGGCTTGTTAGAAAATATGCTAATTGCTATGGTCTCATTATGTTTGCTTAGCTTTTATTTGT
TTTTCTGTGAACAGTTAGAGAGCTAATTTTTTTCAAAGGTGATTGTAAGTCATATTTTATATAGCATTTTGCTTGATTATTTGCTCTGTA
CTGAATTTGTACTCTATTGCCATTAGATCTTACAATAATGTTCCACTCTGCAAATTTTTAAGGTTCAAATAAAGTTTAATTGTTTGCAAA

>16583_16583_4_CHN2-SKAP2_CHN2_chr7_29234606_ENST00000539389_SKAP2_chr7_26779583_ENST00000345317_length(amino acids)=273AA_BP=16
MAASSNSSLSGSSVSSGAQFPPIAAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNT
LRKDGKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVLQDMESDIIPEDYDERGELYDDVDHPLPISNPLTSSQPIDDEIYEELPE
EEEDSAPVKVEEQRKMSQDSVHHTSGDKSTDYANFYQGLWDCTGAFSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHN2-SKAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHN2-SKAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHN2-SKAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource