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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHP1-RAD51 (FusionGDB2 ID:16610)

Fusion Gene Summary for CHP1-RAD51

Fusion gene summary

Fusion gene information	Fusion gene name: CHP1-RAD51
	Fusion gene ID: 16610
		Hgene	Tgene
	Gene symbol	CHP1	RAD51
	Gene ID	26973	5888
	Gene name	cysteine and histidine rich domain containing 1	RAD51 recombinase
	Synonyms	CHP1	BRCC5\|FANCR\|HRAD51\|HsRad51\|HsT16930\|MRMV2\|RAD51A\|RECA
	Cytomap	11q14.3	15q15.1
	Type of gene	protein-coding	protein-coding
	Description	cysteine and histidine-rich domain-containing protein 1CHORD-containing protein 1CHP-1chord domain-containing protein 1cysteine and histidine-rich domain (CHORD) containing 1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein	DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A
	Modification date	20200313	20200322
	UniProtAcc	Q99653	O15315
	Ensembl transtripts involved in fusion gene	ENST00000558351, ENST00000334660, ENST00000560397,	ENST00000267868, ENST00000423169, ENST00000382643, ENST00000530766, ENST00000532743, ENST00000557850,
Fusion gene scores	* DoF score	11 X 13 X 7=1001	7 X 7 X 5=245
	# samples	15	7
	** MAII score	log2(15/1001*10)=-2.73840756834011 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHP1 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHP1(41562816)-RAD51(41011003), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RAD51	GO:0000724	double-strand break repair via homologous recombination	16428451
Tgene	RAD51	GO:0006268	DNA unwinding involved in DNA replication	7988572
Tgene	RAD51	GO:0006974	cellular response to DNA damage stimulus	23509288\|25585578
Tgene	RAD51	GO:0010569	regulation of double-strand break repair via homologous recombination	23754376
Tgene	RAD51	GO:0031297	replication fork processing	25585578
Tgene	RAD51	GO:0051106	positive regulation of DNA ligation	8929543
Tgene	RAD51	GO:0071479	cellular response to ionizing radiation	23509288\|23754376
Tgene	RAD51	GO:0072757	cellular response to camptothecin	23509288

Fusion gene breakpoints across CHP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-55-8085-01A	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+

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Fusion Gene ORF analysis for CHP1-RAD51

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000558351	ENST00000267868	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
3UTR-3CDS	ENST00000558351	ENST00000423169	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
3UTR-intron	ENST00000558351	ENST00000382643	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
3UTR-intron	ENST00000558351	ENST00000530766	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
3UTR-intron	ENST00000558351	ENST00000532743	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
3UTR-intron	ENST00000558351	ENST00000557850	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000334660	ENST00000382643	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000334660	ENST00000530766	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000334660	ENST00000532743	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000334660	ENST00000557850	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000560397	ENST00000382643	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000560397	ENST00000530766	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000560397	ENST00000532743	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
5CDS-intron	ENST00000560397	ENST00000557850	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
In-frame	ENST00000334660	ENST00000267868	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
In-frame	ENST00000334660	ENST00000423169	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
In-frame	ENST00000560397	ENST00000267868	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+
In-frame	ENST00000560397	ENST00000423169	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000334660

CHP1

chr15

41562816

ENST00000423169

RAD51

chr15

41011003

1528

651

1058

331

ENST00000334660

CHP1

chr15

41562816

ENST00000267868

RAD51

chr15

41011003

2214

651

1235

390

ENST00000560397

CHP1

chr15

41562816

ENST00000423169

RAD51

chr15

41011003

1378

501

908

302

ENST00000560397

CHP1

chr15

41562816

ENST00000267868

RAD51

chr15

41011003

2064

501

1085

361

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000334660	ENST00000423169	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+	0.00143779	0.9985623
ENST00000334660	ENST00000267868	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+	0.000817646	0.9991823
ENST00000560397	ENST00000423169	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+	0.001148936	0.99885106
ENST00000560397	ENST00000267868	CHP1	chr15	41562816	+	RAD51	chr15	41011003	+	0.00069662	0.99930334

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Fusion Genomic Features for CHP1-RAD51

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CHP1	chr15	41562816	+	RAD51	chr15	41011002	+	5.77E-10	1
CHP1	chr15	41562816	+	RAD51	chr15	41011002	+	5.77E-10	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHP1-RAD51

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:41562816/chr15:41011003)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHP1 Q99653	RAD51 O15315
FUNCTION: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner. {ECO:0000269\|PubMed:10593895, ECO:0000269\|PubMed:11350981, ECO:0000269\|PubMed:15035633, ECO:0000269\|PubMed:8901634}.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

123_134

137

196.0

Calcium binding

Note=1

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

26_61

137

196.0

Domain

EF-hand 1

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

66_101

137

196.0

Domain

EF-hand 2

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000557850

48_77

243.0

Domain

Note=HhH

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000557850

127_134

243.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

164_175

137

196.0

Calcium binding

Note=2

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

110_145

137

196.0

Domain

EF-hand 3

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

151_186

137

196.0

Domain

EF-hand 4

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

138_147

137

196.0

Motif

Nuclear export signal 1

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

176_185

137

196.0

Motif

Nuclear export signal 2

Hgene

CHP1

chr15:41562816

chr15:41011003

ENST00000334660

143_185

137

196.0

Region

Note=Necessary for nuclear export signal

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000267868

48_77

145

340.0

Domain

Note=HhH

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000382643

48_77

146

341.0

Domain

Note=HhH

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000423169

48_77

145

281.0

Domain

Note=HhH

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000532743

48_77

146

341.0

Domain

Note=HhH

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000267868

127_134

145

340.0

Nucleotide binding

ATP

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000382643

127_134

146

341.0

Nucleotide binding

ATP

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000423169

127_134

145

281.0

Nucleotide binding

ATP

Tgene

RAD51

chr15:41562816

chr15:41011003

ENST00000532743

127_134

146

341.0

Nucleotide binding

ATP

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Fusion Gene Sequence for CHP1-RAD51

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16610_16610_1_CHP1-RAD51_CHP1_chr15_41562816_ENST00000334660_RAD51_chr15_41011003_ENST00000267868_length(transcript)=2214nt_BP=651nt
CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC
CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC
TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG
GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGCCTCTACAGCCGGTTCACCAGCCTGGACAAA
GGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAACCCACTGGGGGACCGGATCATCAATGCCTTC
TTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTCCGCCCCATTGAGGATAATGAAAAGAGCAAA
GATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGACTATATGATTTGGATAAAGATGAAAAGATC
TCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCA
GAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGAC
CACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTAC
AGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAG
TTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATGTTTGCTGCTGATCCCAAAAAACCTATTGGA
GGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCC
TGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAA
AAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTT
CCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTT
CTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGT
TTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTA
AAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTGTCAGTAAAACTCTCAAGCAGGTTTTTAAGT
TGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTAGGCCATTAGCCCTTCACCATCTACCTGCTT
GGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCAGTGTGGTGTCTTGCGCCTGTACTCCCAGCA
CTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCCAAGGTGGTGAAATCCCATCTCTACAAAAAA
TGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCCTGAGGTGGGAGAATCACTTAAGCCTGGAAG
GTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGGTGACAGAGTGAGACCATGTTTCAAACAAGAAACATTTCAGAG

>16610_16610_1_CHP1-RAD51_CHP1_chr15_41562816_ENST00000334660_RAD51_chr15_41011003_ENST00000267868_length(amino acids)=390AA_BP=26
MAGPRGRPPQRTTPGFPPGSAVETLPSPFLTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGFSHSQITRL
YSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRL
YDLDKDEKISRDELLQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALL
IVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGET

--------------------------------------------------------------
>16610_16610_2_CHP1-RAD51_CHP1_chr15_41562816_ENST00000334660_RAD51_chr15_41011003_ENST00000423169_length(transcript)=1528nt_BP=651nt
CATTCGGGGCTGGAACTCGAACGCTGACGTTGGCTCCTGAGCCGGGCGCTGCCTCGCGCCTGATTGGCGGGTCCTCGGGGCCGCCCTCCC
CAGCGCACCACCCCTGGGTTCCCTCCCGGGTCCGCAGTGGAAACACTGCCCTCTCCCTTCTTGACCCCTAGCCCTTCCTTCCCTCCCTCC
TTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCGATGGGTTCTCGGGCCTCCACGTTACTGCGG
GACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGCCTCTACAGCCGGTTCACCAGCCTGGACAAA
GGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAACCCACTGGGGGACCGGATCATCAATGCCTTC
TTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTCCGCCCCATTGAGGATAATGAAAAGAGCAAA
GATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGACTATATGATTTGGATAAAGATGAAAAGATC
TCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATGTACATTGACACTGAGGGTACCTTTAGGCCA
GAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAATGTAGCATATGCTCGAGCGTTCAACACAGAC
CACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTGCTTATTGTAGACAGTGCCACCGCCCTTTAC
AGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTTCTGCGGATGCTTCTGCGACTCGCTGATGAG
ATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCAT
TAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGC
ACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTG
ATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTT
GGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTT

>16610_16610_2_CHP1-RAD51_CHP1_chr15_41562816_ENST00000334660_RAD51_chr15_41011003_ENST00000423169_length(amino acids)=331AA_BP=26
MAGPRGRPPQRTTPGFPPGSAVETLPSPFLTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGFSHSQITRL
YSRFTSLDKGENGTLSREDFQRIPELAINPLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRL
YDLDKDEKISRDELLQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALL

--------------------------------------------------------------
>16610_16610_3_CHP1-RAD51_CHP1_chr15_41562816_ENST00000560397_RAD51_chr15_41011003_ENST00000267868_length(transcript)=2064nt_BP=501nt
TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG
ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC
CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC
CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC
CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA
CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG
TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT
GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG
CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT
CTGCGGATGCTTCTGCGACTCGCTGATGAGTTTGGTGTAGCAGTGGTAATCACTAATCAGGTGGTAGCTCAAGTGGATGGAGCAGCGATG
TTTGCTGCTGATCCCAAAAAACCTATTGGAGGAAATATCATCGCCCATGCATCAACAACCAGATTGTATCTGAGGAAAGGAAGAGGGGAA
ACCAGAATCTGCAAAATCTACGACTCTCCCTGTCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAA
GACTGAATCATTGGGTTTTTCCTCTGTTAAAAACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCT
CTTCCTGTTGTGACTGCCAGGATAAAGCTTCCGGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAG
TCACAAACTGATCTAAAATGTTTATTCCTTCTGTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCT
TTGACATGGTGCCTTAGGAATGACTTGGGTTTAACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCT
GACCCTTCTCTCACTTCTAAATTAATGGTAAAATAAAATGCCTCAGCTATGTAGCAAAGGGAATGGGTCTGCACAGATTCTTTTTTTCTG
TCAGTAAAACTCTCAAGCAGGTTTTTAAGTTGTCTGTCTGAATGATCTTGTGTAAGGTTTTGGTTATGGAGTCTTGTGCCAAACCTACTA
GGCCATTAGCCCTTCACCATCTACCTGCTTGGTCTTTCATTGCTAAGACTAACTCAAGATAATCCTAGAGTCTTAAAGCATTTCAGGCCA
GTGTGGTGTCTTGCGCCTGTACTCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCGCTTGAGCCCAGGAGTTTTAAGTCCAGCTTGGCC
AAGGTGGTGAAATCCCATCTCTACAAAAAATGCAGAACTTAATCTGGACACACTGTTACACGTGCCTGTAGTCCCAGCTACTCGATAGCC
TGAGGTGGGAGAATCACTTAAGCCTGGAAGGTGGAAGTTGCAGTGAGTCGAGATTGCACTGCTGCATTCCAGCCAGGGTGACAGAGTGAG

>16610_16610_3_CHP1-RAD51_CHP1_chr15_41562816_ENST00000560397_RAD51_chr15_41011003_ENST00000267868_length(amino acids)=361AA_BP=165
LTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQLPIDRGGGEGKAM
YIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARF
LRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAK

--------------------------------------------------------------
>16610_16610_4_CHP1-RAD51_CHP1_chr15_41562816_ENST00000560397_RAD51_chr15_41011003_ENST00000423169_length(transcript)=1378nt_BP=501nt
TTGACCCCTAGCCCTTCCTTCCCTCCCTCCTTCCCTCCTGTCGCCGTCTCTTCTGGCGCCGCTGCTCCCGGAGGAGCTCCCGGCACGGCG
ATGGGTTCTCGGGCCTCCACGTTACTGCGGGACGAAGAGCTCGAGGAGATCAAGAAGGAGACCGGCTTTTCCCACAGTCAAATCACTCGC
CTCTACAGCCGGTTCACCAGCCTGGACAAAGGAGAGAATGGGACTCTCAGCCGGGAAGATTTCCAGAGGATTCCAGAACTTGCCATCAAC
CCACTGGGGGACCGGATCATCAATGCCTTCTTTCCAGAGGGAGAGGACCAGGTAAACTTCCGTGGATTCATGCGAACTTTGGCTCATTTC
CGCCCCATTGAGGATAATGAAAAGAGCAAAGATGTGAATGGACCCGAACCACTCAACAGCCGAAGCAACAAACTGCACTTTGCTTTTCGA
CTATATGATTTGGATAAAGATGAAAAGATCTCCCGTGATGAGCTGTTACAGCTTCCCATTGACCGGGGTGGAGGTGAAGGAAAGGCCATG
TACATTGACACTGAGGGTACCTTTAGGCCAGAACGGCTGCTGGCAGTGGCTGAGAGGTATGGTCTCTCTGGCAGTGATGTCCTGGATAAT
GTAGCATATGCTCGAGCGTTCAACACAGACCACCAGACCCAGCTCCTTTATCAAGCATCAGCCATGATGGTAGAATCTAGGTATGCACTG
CTTATTGTAGACAGTGCCACCGCCCTTTACAGAACAGACTACTCGGGTCGAGGTGAGCTTTCAGCCAGGCAGATGCACTTGGCCAGGTTT
CTGCGGATGCTTCTGCGACTCGCTGATGAGATTGTATCTGAGGAAAGGAAGAGGGGAAACCAGAATCTGCAAAATCTACGACTCTCCCTG
TCTTCCTGAAGCTGAAGCTATGTTCGCCATTAATGCAGATGGAGTGGGAGATGCCAAAGACTGAATCATTGGGTTTTTCCTCTGTTAAAA
ACCTTAAGTGCTGCAGCCTAATGAGAGTGCACTGCTCCCTGGGGTTCTCTACAGGCCTCTTCCTGTTGTGACTGCCAGGATAAAGCTTCC
GGGAAAACAGCTATTATATCAGCTTTTCTGATGGTATAAACAGGAGACAGGTCAGTAGTCACAAACTGATCTAAAATGTTTATTCCTTCT
GTAGTGTATTAATCTCTGTGTGTTTTCTTTGGTTTTGGAGGAGGGGTATGAAGTATCTTTGACATGGTGCCTTAGGAATGACTTGGGTTT
AACAAGCTGTCTACTGGACAATCTTATGTTTCCAAGAGAACTAAAGCTGGAGAGACCTGACCCTTCTCTCACTTCTAAATTAATGGTAAA

>16610_16610_4_CHP1-RAD51_CHP1_chr15_41562816_ENST00000560397_RAD51_chr15_41011003_ENST00000423169_length(amino acids)=302AA_BP=165
LTPSPSFPPSFPPVAVSSGAAAPGGAPGTAMGSRASTLLRDEELEEIKKETGFSHSQITRLYSRFTSLDKGENGTLSREDFQRIPELAIN
PLGDRIINAFFPEGEDQVNFRGFMRTLAHFRPIEDNEKSKDVNGPEPLNSRSNKLHFAFRLYDLDKDEKISRDELLQLPIDRGGGEGKAM
YIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CHP1-RAD51

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	RAD51	chr15:41562816	chr15:41011003	ENST00000267868		4	10	184_257	145.0	340.0	PALB2
Tgene	RAD51	chr15:41562816	chr15:41011003	ENST00000382643		4	10	184_257	146.0	341.0	PALB2
Tgene	RAD51	chr15:41562816	chr15:41011003	ENST00000423169		4	9	184_257	145.0	281.0	PALB2
Tgene	RAD51	chr15:41562816	chr15:41011003	ENST00000532743		4	10	184_257	146.0	341.0	PALB2
Tgene	RAD51	chr15:41562816	chr15:41011003	ENST00000557850		0	8	184_257	0	243.0	PALB2

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CHP1-RAD51

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CHP1-RAD51

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source