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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHST8-ZNF708 (FusionGDB2 ID:16714)

Fusion Gene Summary for CHST8-ZNF708

check button Fusion gene summary
Fusion gene informationFusion gene name: CHST8-ZNF708
Fusion gene ID: 16714
HgeneTgene
Gene symbol

CHST8

ZNF708

Gene ID

64377

7562

Gene namecarbohydrate sulfotransferase 8zinc finger protein 708
SynonymsGALNAC4ST1|GalNAc4ST|PSS3KOX8|ZNF15|ZNF15L1
Cytomap

19q13.11

19p12

Type of geneprotein-codingprotein-coding
Descriptioncarbohydrate sulfotransferase 8GALNAC-4-ST1GalNAc-4-O-sulfotransferase 1N-acetylgalactosamine-4-O-sulfotransferase 1carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8galNAc4ST-1zinc finger protein 708ZNF15, ZNF15L1zinc finger protein 15-like 1 (KOX 8)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000604556, ENST00000262622, 
ENST00000434302, ENST00000438847, 
ENST00000356929, 
Fusion gene scores* DoF score7 X 3 X 7=1472 X 2 X 2=8
# samples 82
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: CHST8 [Title/Abstract] AND ZNF708 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHST8(34180297)-ZNF708(21477541), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHST8

GO:0006790

sulfur compound metabolic process

11445554

HgeneCHST8

GO:0030166

proteoglycan biosynthetic process

10988300


check buttonFusion gene breakpoints across CHST8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF708 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-VF-A8ADCHST8chr19

34180297

+ZNF708chr19

21477541

-


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Fusion Gene ORF analysis for CHST8-ZNF708

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000604556ENST00000356929CHST8chr19

34180297

+ZNF708chr19

21477541

-
In-frameENST00000262622ENST00000356929CHST8chr19

34180297

+ZNF708chr19

21477541

-
In-frameENST00000434302ENST00000356929CHST8chr19

34180297

+ZNF708chr19

21477541

-
In-frameENST00000438847ENST00000356929CHST8chr19

34180297

+ZNF708chr19

21477541

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000434302CHST8chr1934180297+ENST00000356929ZNF708chr1921477541-42156354902100536
ENST00000438847CHST8chr1934180297+ENST00000356929ZNF708chr1921477541-41225423972007536
ENST00000262622CHST8chr1934180297+ENST00000356929ZNF708chr1921477541-44688887432353536

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000434302ENST00000356929CHST8chr1934180297+ZNF708chr1921477541-0.0006030890.9993969
ENST00000438847ENST00000356929CHST8chr1934180297+ZNF708chr1921477541-0.0005918980.9994081
ENST00000262622ENST00000356929CHST8chr1934180297+ZNF708chr1921477541-0.0007130980.99928695

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Fusion Genomic Features for CHST8-ZNF708


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHST8-ZNF708


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34180297/chr19:21477541)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHST8chr19:34180297chr19:21477541ENST00000262622+241_1043425.0Topological domainCytoplasmic
HgeneCHST8chr19:34180297chr19:21477541ENST00000434302+351_1043425.0Topological domainCytoplasmic
HgeneCHST8chr19:34180297chr19:21477541ENST00000438847+241_1043425.0Topological domainCytoplasmic
HgeneCHST8chr19:34180297chr19:21477541ENST00000262622+2411_3143425.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCHST8chr19:34180297chr19:21477541ENST00000434302+3511_3143425.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCHST8chr19:34180297chr19:21477541ENST00000438847+2411_3143425.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924104_12675564.0Zinc fingerC2H2-type 2
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924132_15475564.0Zinc fingerC2H2-type 3
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924160_18275564.0Zinc fingerC2H2-type 4
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924188_21075564.0Zinc fingerC2H2-type 5
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924216_23875564.0Zinc fingerC2H2-type 6
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924244_26675564.0Zinc fingerC2H2-type 7
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924272_29475564.0Zinc fingerC2H2-type 8
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924300_32275564.0Zinc fingerC2H2-type 9
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924328_35075564.0Zinc fingerC2H2-type 10
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924356_37875564.0Zinc fingerC2H2-type 11
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924384_40675564.0Zinc fingerC2H2-type 12
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924412_43475564.0Zinc fingerC2H2-type 13
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924440_46275564.0Zinc fingerC2H2-type 14
TgeneZNF708chr19:34180297chr19:21477541ENST0000035692924468_49075564.0Zinc fingerC2H2-type 15
TgeneZNF708chr19:34180297chr19:21477541ENST000003569292476_9875564.0Zinc fingerC2H2-type 1%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHST8chr19:34180297chr19:21477541ENST00000262622+24198_20443425.0Nucleotide bindingPAPS
HgeneCHST8chr19:34180297chr19:21477541ENST00000262622+24258_26643425.0Nucleotide bindingPAPS
HgeneCHST8chr19:34180297chr19:21477541ENST00000434302+35198_20443425.0Nucleotide bindingPAPS
HgeneCHST8chr19:34180297chr19:21477541ENST00000434302+35258_26643425.0Nucleotide bindingPAPS
HgeneCHST8chr19:34180297chr19:21477541ENST00000438847+24198_20443425.0Nucleotide bindingPAPS
HgeneCHST8chr19:34180297chr19:21477541ENST00000438847+24258_26643425.0Nucleotide bindingPAPS
HgeneCHST8chr19:34180297chr19:21477541ENST00000262622+2432_42443425.0Topological domainLumenal
HgeneCHST8chr19:34180297chr19:21477541ENST00000434302+3532_42443425.0Topological domainLumenal
HgeneCHST8chr19:34180297chr19:21477541ENST00000438847+2432_42443425.0Topological domainLumenal


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Fusion Gene Sequence for CHST8-ZNF708


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16714_16714_1_CHST8-ZNF708_CHST8_chr19_34180297_ENST00000262622_ZNF708_chr19_21477541_ENST00000356929_length(transcript)=4468nt_BP=888nt
GGGACTCGTCCCAGAGTTTGCTGCCGCCGCCGCCGCTGCCATTAGAGCGGTTTTAATTAGCTGCAGGATTTTTAATGAGCTGAAATCAAG
AAGAGCCCCATCTCAGAAGTAAGCGAGAGCCGCGCGCAGGGAAGAACTAGTCTGACAAAACAGAAGGAGGTGGTGCTCTCGGGGGACTGG
GCTGTAGGCTCCCACCGATCGATCGGCGACGAGCAGATGAGTTCCCGAGGCCAGGAGGCTGAGGAGGGAAGCCAGGGCTCAGAGACCAGC
GCCCGGTGCAGAGTCCCCGCTGCTGCCACCGCGGCAGAAGGCACGGTGCCGGATTCAAGGTGACGGCAGTGCCTGGCTCCATTCTCCTCA
AGTTGCCATAGCAGCCTCTCTCCCAACAAGCAGCTTCTCCGGGAGCCCTCAGCCGGGAGGGACGTCATTGTTCTCTCCTGCCCGTGTGGT
GCAAGGAGACCCACCGGACAGAGAACTTTCCCGAGCCCGGGGTCCGCTGACCACGTGGGTGCACCCATGCTGCCTGGAGCCAGGCACAGG
GACAGGTCCCCACGGCCACAGGGAATCCTCTGGGCAGCTGAGGGGAGCGTCCAGGCCCAGAAGCAGCTGCAGCCAAGCGTGTCCTTGGAG
CCGTCCATGCGTCTGTCCGCCTGCTGCCGGTCGCCACTGGAGATCTCGGCCTGATGGACGCCTGGTGTGGACGATGAGGGAAGAACGTGC
CCCCCACACCCAAGAGGTGACCCCTGAGCCAGCCCCGGATGACCCTGCGACCTGGAACAATGCGGCTGGCCTGCATGTTCTCTTCCATCC
TGCTGTTCGGAGCTGCAGGCCTCCTCCTCTTCATCAGCCTGCAGGACCCTACGGAGCTCGCCCCCCAGCAGGTGCCAGCTATGTGTTCTC
ATTTTGCCAAAGACCTTAGGCCAGAGCAATATATAAAAAATTCTTTCCAACAAGTGATACTGAGAAGATATGGAAAATGTGGATATCAGA
AAGGCTGTAAAAGTGTGGATGAGCATAAGTTGCACAAAGGAGGTCACAAGGGACTTAACCGGTGTGTGACAACTACCCAGAGCAAAATAG
TTCAGTGTGACAAATACGTGAAAGTCTTTCATAAATATTCAAATGCAAAGAGACATAAGATAAGACATACTGGAAAAAATCCTTTCAAAT
GTAAAGAATGTGGCAAATCATTTTGCATGCTTTCACAACTAACTCAACATGAGATAATTCATACTGGAGAAAAACCCTACAAATGTGAAG
AATGTGGCAAAGCTTTTAAAAAGTCCTCAAACCTTACGAATCATAAGATAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTG
GAAAAGCTTTTAACCAGTCCTCAACTCTTACTAGACATAAGATAATTCATACTGGAGAGAAACTCTACAAATGTGAAGAATGTGGCAAAG
CTTTTAACCGGTCCTCAAACCTTACTAAACATAAGATAGTTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTA
AACAGTCCTCAAACCTTACTAATCACAAGAAAATTCATACTGGAGAGAAACCCTACAAATGTGGAGAATGTGGCAAAGCCTTTACCCTAT
CTTCACACCTTACTACACATAAGAGGATTCATACTGGTGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAGTGTATTTTCAA
CCCTTACTAAACATAAGATAATTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCGGTCCTCACACCTTA
CTAATCATAAGGTAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTTACCAAGTCCTCAACTCTTACTTATC
ATAAGGTAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTTAGTATATTCTCAATCCTTACTAAACATAAAG
TAATTCATACTGAAGACAAACCCTACAAATGTGAAGAATGTGGCAAAACTTTTAACTACTCCTCAAATTTTACTAATCATAAAAAAATTC
ATACTGGAGAGAAACCCTATAAGTGTGAAGAATGTGGCAAAAGCTTTATTCTGTCCTCTCATCTTACTACACATAAGATAATTCATACTG
GAGAGAAACCCTACAAATGTAAAGAATGTGGCAAAGCTTTTAACCAGTCCTCAACCCTTATGAAACATAAGATAATTCATACTGGAGAGA
AACCCTACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTCCCCAAACCTTACTAAACATAAGAGAATTCATACCAAAGAGAAACCCT
ACAAATGTAAATAATGTGTCAAATCCTTTAGTGTATTTTCAACTTTTATTAAAACACAAGATAATTCATACTGGAGAGAAATCCTACAAA
TGTGATAAATGTGGCAAAGCCTTTAACTGGCTCTTAATCCTTATGAAACAAAAGATAATTCATACTAGAGAGAAACCCTACAAATGTAAA
GAATGTGGCAAAGCATTTAACTGGTCCCTAAATCTTACTAAACATAAAAAAACTTAAACTGGAGAGAAACTACAAAGCTGGAAGACATCA
CAGTAATTCTGACAACACCTCAAACTTTTCTAAACATAAAATAAATCATACTGGTGAGGAACTTTAAAAATGCGAAAAATGTGACAAAAT
CTTTAAATGATTGTCACACTTGATTGTAGGTAAGATAATTCTTACTAGAAAAACTCTTACAAGTGTGAAGAATGTGGCAAAATTTTTAAT
GAATACTCACACCTTATTGCCAGGAAAGCATTTATACTTGAGAAAAATTGTACCAATATAAAGACTGTGAAAAAGCCATTAATGTCTGCT
CACATCTTACTCAACATCAGAGAGTACTTAAAAAAAGTATTATAAATTTAATTACTGTCAAAAAGTATTTCAGAAAATATAAGCTTTTAA
AGTATTTATTTTGAAGACAAACATTACAAATAAAAGAGGATTGTAATACCTTTATTTGTATCACAGATCTTATTGTACACATTTTGTACT
AGAGAAAACCCTGAAGCAGTTACTTAAACTTTGTTCAACATCAGGGAATTCAGATTGGAGAAAAACCCTGCAAATGTAATAAATTTGAAA
AAAAAGTTTTCCAAAACTACAACTTAGACAACACCAGAGGGTTCATACTGAGATATATTTTTGCAGATGCAGTATATATTTAAAACATTT
AATCCAAAATAAGTCTATGTAAATATCAGAGAATTCACAGTGGAAATATCTAAGGTAGGGCCGGGCATGGTGGCTCACGCCTGTAATGCC
AGCACTTTGGGAGGCTGAGGTGGGCAGATCATGAGGTCAACAGATTGAGACCATCCTGGTCAACATGGTAAAACCCTGTCTCTACTAAAA
ATACAAAAATTAGCTGGGCGTGGCGGCACGTGCCTGTAGTCTCAGCTACTTGGGACGCTGAGGCAGGAAAATCCGTTGAACCCAGGAGGC
AGAGGTTGTAGTGAGCCGAGATTGCACCACTGCACTCCAGCCGGGTGACAGAGTGAGACTCCATCTCAAAAACAAACAAACTAAGGTATG
GATGCTTCAGACATTACACTATATCAAAGTGCTGACTGTTAAAAATGATCCCAAACTAACGGTAGATAAATTTATTTGTACATAACTTTA
AAAGGAGTAGAAGATTTTTTGGAAGTTTGTAATTACATTCAAAGTATACTTTTTTTGTTTGTTTGTTTTCCTTGAGACAGAGTCTCTCTC
TGTCGTCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCGCTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTACT
GAGTAGCTGAGATTACAGGTGCACACCACCACGTCCGGCTGACTTTTGTATTTTTAGTAGGGACGGGGTTTCACCATATTGGTCAGGGTA
GTCTTGAACTCCTGACCTCATGCTCTGCCCAGCTTGGCTTCCCAAAGTGCTGTGATTACAGGCTTAAGCCACAGCGCCCGGCCCAAAGTG
TTCTTTTTTCCTTGAAAAGAAGTACAGATTTTTTAAAAAGCTAATATTGCTGTGATTCAACTCTCTAGTTACTTGATGCTATTTCTTCAT
TTCTATTGTATTCACATGTGAAAGCATGTGATCAGTTGTCACGGCATCAAAGATAGGAGAGTTTCTTTTTTTTTAGGTGGGCATTATTTA
TGACCTTTTCTTTGGAAGAGTAAGGACATTAAAATGTAACATGCATGATGAAAATCTAAGTGGAGATGGTATTTGTGGTTAATTATGATA
TTGAGTGGTGCATGAGGTAGGTGTTTAGAGTAATATTCTTTTGCATTATAGTAAGAACATTTAAGTTTTGTTAAAATTAAAAAATTAGTA

>16714_16714_1_CHST8-ZNF708_CHST8_chr19_34180297_ENST00000262622_ZNF708_chr19_21477541_ENST00000356929_length(amino acids)=536AA_BP=50
MSQPRMTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPAMCSHFAKDLRPEQYIKNSFQQVILRRYGKCGYQKGCKSVDE
HKLHKGGHKGLNRCVTTTQSKIVQCDKYVKVFHKYSNAKRHKIRHTGKNPFKCKECGKSFCMLSQLTQHEIIHTGEKPYKCEECGKAFKK
SSNLTNHKIIHTGEKPYKCEECGKAFNQSSTLTRHKIIHTGEKLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTN
HKKIHTGEKPYKCGECGKAFTLSSHLTTHKRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHT
GEKPYKCEECGKAFTKSSTLTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDKPYKCEECGKTFNYSSNFTNHKKIHTGEKPYK

--------------------------------------------------------------
>16714_16714_2_CHST8-ZNF708_CHST8_chr19_34180297_ENST00000434302_ZNF708_chr19_21477541_ENST00000356929_length(transcript)=4215nt_BP=635nt
TTCGCTGGGAGCCTTCCCGGCGCGCAAGCCGGATCCGGCAGTGCTGCGGGGAGGAGAGAGGACGAGGCGGCGGCGGCAGCAGGAGGTGGG
GGACCGATCGCGCCGGGGGCCGAAGAGGAACGCCGCCCCGCGCCCTCTCGCTCCCCGCACGCTCCGGCTGCCGGCCCCACGCTGCTCGCC
CACAGATCGCACTGGGTTCCGCTTGGAGCGGGCGGAGGCACCGGGCCCGAGCTGGGTCGGAGGTCCTCTCCGCCGCCTGCGCGCCCCAAG
CAGAGGATCCGCCGCGGAGAACCGCTCCCGGACTGGAGGCGCCCGCGGCCTCGGGTGCGTCCGCTGCGCCAGGTTTAAAGGTCAACAAGA
ATATCTTACCTTAATTTGACAAGTACGCAAGAAATAATGCAAGACTCGTTTATGTTCAGATCTCGGCCTGATGGACGCCTGGTGTGGACG
ATGAGGGAAGAACGTGCCCCCCACACCCAAGAGGTGACCCCTGAGCCAGCCCCGGATGACCCTGCGACCTGGAACAATGCGGCTGGCCTG
CATGTTCTCTTCCATCCTGCTGTTCGGAGCTGCAGGCCTCCTCCTCTTCATCAGCCTGCAGGACCCTACGGAGCTCGCCCCCCAGCAGGT
GCCAGCTATGTGTTCTCATTTTGCCAAAGACCTTAGGCCAGAGCAATATATAAAAAATTCTTTCCAACAAGTGATACTGAGAAGATATGG
AAAATGTGGATATCAGAAAGGCTGTAAAAGTGTGGATGAGCATAAGTTGCACAAAGGAGGTCACAAGGGACTTAACCGGTGTGTGACAAC
TACCCAGAGCAAAATAGTTCAGTGTGACAAATACGTGAAAGTCTTTCATAAATATTCAAATGCAAAGAGACATAAGATAAGACATACTGG
AAAAAATCCTTTCAAATGTAAAGAATGTGGCAAATCATTTTGCATGCTTTCACAACTAACTCAACATGAGATAATTCATACTGGAGAAAA
ACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAAAAAGTCCTCAAACCTTACGAATCATAAGATAATTCATACTGGAGAGAAACCCTA
CAAATGTGAAGAATGTGGAAAAGCTTTTAACCAGTCCTCAACTCTTACTAGACATAAGATAATTCATACTGGAGAGAAACTCTACAAATG
TGAAGAATGTGGCAAAGCTTTTAACCGGTCCTCAAACCTTACTAAACATAAGATAGTTCATACTGGAGAGAAACCCTACAAATGTGAAGA
ATGTGGCAAAGCTTTTAAACAGTCCTCAAACCTTACTAATCACAAGAAAATTCATACTGGAGAGAAACCCTACAAATGTGGAGAATGTGG
CAAAGCCTTTACCCTATCTTCACACCTTACTACACATAAGAGGATTCATACTGGTGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGC
TTTTAGTGTATTTTCAACCCTTACTAAACATAAGATAATTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAA
CCGGTCCTCACACCTTACTAATCATAAGGTAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTTACCAAGTC
CTCAACTCTTACTTATCATAAGGTAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTTAGTATATTCTCAAT
CCTTACTAAACATAAAGTAATTCATACTGAAGACAAACCCTACAAATGTGAAGAATGTGGCAAAACTTTTAACTACTCCTCAAATTTTAC
TAATCATAAAAAAATTCATACTGGAGAGAAACCCTATAAGTGTGAAGAATGTGGCAAAAGCTTTATTCTGTCCTCTCATCTTACTACACA
TAAGATAATTCATACTGGAGAGAAACCCTACAAATGTAAAGAATGTGGCAAAGCTTTTAACCAGTCCTCAACCCTTATGAAACATAAGAT
AATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTCCCCAAACCTTACTAAACATAAGAGAATTCA
TACCAAAGAGAAACCCTACAAATGTAAATAATGTGTCAAATCCTTTAGTGTATTTTCAACTTTTATTAAAACACAAGATAATTCATACTG
GAGAGAAATCCTACAAATGTGATAAATGTGGCAAAGCCTTTAACTGGCTCTTAATCCTTATGAAACAAAAGATAATTCATACTAGAGAGA
AACCCTACAAATGTAAAGAATGTGGCAAAGCATTTAACTGGTCCCTAAATCTTACTAAACATAAAAAAACTTAAACTGGAGAGAAACTAC
AAAGCTGGAAGACATCACAGTAATTCTGACAACACCTCAAACTTTTCTAAACATAAAATAAATCATACTGGTGAGGAACTTTAAAAATGC
GAAAAATGTGACAAAATCTTTAAATGATTGTCACACTTGATTGTAGGTAAGATAATTCTTACTAGAAAAACTCTTACAAGTGTGAAGAAT
GTGGCAAAATTTTTAATGAATACTCACACCTTATTGCCAGGAAAGCATTTATACTTGAGAAAAATTGTACCAATATAAAGACTGTGAAAA
AGCCATTAATGTCTGCTCACATCTTACTCAACATCAGAGAGTACTTAAAAAAAGTATTATAAATTTAATTACTGTCAAAAAGTATTTCAG
AAAATATAAGCTTTTAAAGTATTTATTTTGAAGACAAACATTACAAATAAAAGAGGATTGTAATACCTTTATTTGTATCACAGATCTTAT
TGTACACATTTTGTACTAGAGAAAACCCTGAAGCAGTTACTTAAACTTTGTTCAACATCAGGGAATTCAGATTGGAGAAAAACCCTGCAA
ATGTAATAAATTTGAAAAAAAAGTTTTCCAAAACTACAACTTAGACAACACCAGAGGGTTCATACTGAGATATATTTTTGCAGATGCAGT
ATATATTTAAAACATTTAATCCAAAATAAGTCTATGTAAATATCAGAGAATTCACAGTGGAAATATCTAAGGTAGGGCCGGGCATGGTGG
CTCACGCCTGTAATGCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCATGAGGTCAACAGATTGAGACCATCCTGGTCAACATGGTAAAA
CCCTGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGCGGCACGTGCCTGTAGTCTCAGCTACTTGGGACGCTGAGGCAGGAAAATC
CGTTGAACCCAGGAGGCAGAGGTTGTAGTGAGCCGAGATTGCACCACTGCACTCCAGCCGGGTGACAGAGTGAGACTCCATCTCAAAAAC
AAACAAACTAAGGTATGGATGCTTCAGACATTACACTATATCAAAGTGCTGACTGTTAAAAATGATCCCAAACTAACGGTAGATAAATTT
ATTTGTACATAACTTTAAAAGGAGTAGAAGATTTTTTGGAAGTTTGTAATTACATTCAAAGTATACTTTTTTTGTTTGTTTGTTTTCCTT
GAGACAGAGTCTCTCTCTGTCGTCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCGCTGCAACCTCTGCCTCCTGGGTTCAAGCAATTC
TCCTGCCTCAGCCTACTGAGTAGCTGAGATTACAGGTGCACACCACCACGTCCGGCTGACTTTTGTATTTTTAGTAGGGACGGGGTTTCA
CCATATTGGTCAGGGTAGTCTTGAACTCCTGACCTCATGCTCTGCCCAGCTTGGCTTCCCAAAGTGCTGTGATTACAGGCTTAAGCCACA
GCGCCCGGCCCAAAGTGTTCTTTTTTCCTTGAAAAGAAGTACAGATTTTTTAAAAAGCTAATATTGCTGTGATTCAACTCTCTAGTTACT
TGATGCTATTTCTTCATTTCTATTGTATTCACATGTGAAAGCATGTGATCAGTTGTCACGGCATCAAAGATAGGAGAGTTTCTTTTTTTT
TAGGTGGGCATTATTTATGACCTTTTCTTTGGAAGAGTAAGGACATTAAAATGTAACATGCATGATGAAAATCTAAGTGGAGATGGTATT
TGTGGTTAATTATGATATTGAGTGGTGCATGAGGTAGGTGTTTAGAGTAATATTCTTTTGCATTATAGTAAGAACATTTAAGTTTTGTTA

>16714_16714_2_CHST8-ZNF708_CHST8_chr19_34180297_ENST00000434302_ZNF708_chr19_21477541_ENST00000356929_length(amino acids)=536AA_BP=50
MSQPRMTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPAMCSHFAKDLRPEQYIKNSFQQVILRRYGKCGYQKGCKSVDE
HKLHKGGHKGLNRCVTTTQSKIVQCDKYVKVFHKYSNAKRHKIRHTGKNPFKCKECGKSFCMLSQLTQHEIIHTGEKPYKCEECGKAFKK
SSNLTNHKIIHTGEKPYKCEECGKAFNQSSTLTRHKIIHTGEKLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTN
HKKIHTGEKPYKCGECGKAFTLSSHLTTHKRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHT
GEKPYKCEECGKAFTKSSTLTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDKPYKCEECGKTFNYSSNFTNHKKIHTGEKPYK

--------------------------------------------------------------
>16714_16714_3_CHST8-ZNF708_CHST8_chr19_34180297_ENST00000438847_ZNF708_chr19_21477541_ENST00000356929_length(transcript)=4122nt_BP=542nt
CCGGCGCGCAAGCCGGATCCGGCAGTGCTGCGGGGAGGAGAGAGGACGAGGCGGCGGCGGCAGCAGGAGGTGGGGGACCGATCGCGCCGG
GGGCCGAAGAGGAACGCCGCCCCGCGCCCTCTCGCTCCCCGCACGCTCCGGCTGCCGGCCCCACGCTGCTCGCCCACAGATCGCACTGGG
TTCCGCTTGGAGCGGGCGGAGGCACCGGGCCCGAGCTGGGTCGGAGGTCCTCTCCGCCGCCTGCGCGCCCCAAGCAGAGGATCCGCCGCG
GAGAACCGCTCCCGGACTGGAGGCGCCCGCGGCCTCGGGTGCGTCCGCTGCGCCAGATCTCGGCCTGATGGACGCCTGGTGTGGACGATG
AGGGAAGAACGTGCCCCCCACACCCAAGAGGTGACCCCTGAGCCAGCCCCGGATGACCCTGCGACCTGGAACAATGCGGCTGGCCTGCAT
GTTCTCTTCCATCCTGCTGTTCGGAGCTGCAGGCCTCCTCCTCTTCATCAGCCTGCAGGACCCTACGGAGCTCGCCCCCCAGCAGGTGCC
AGCTATGTGTTCTCATTTTGCCAAAGACCTTAGGCCAGAGCAATATATAAAAAATTCTTTCCAACAAGTGATACTGAGAAGATATGGAAA
ATGTGGATATCAGAAAGGCTGTAAAAGTGTGGATGAGCATAAGTTGCACAAAGGAGGTCACAAGGGACTTAACCGGTGTGTGACAACTAC
CCAGAGCAAAATAGTTCAGTGTGACAAATACGTGAAAGTCTTTCATAAATATTCAAATGCAAAGAGACATAAGATAAGACATACTGGAAA
AAATCCTTTCAAATGTAAAGAATGTGGCAAATCATTTTGCATGCTTTCACAACTAACTCAACATGAGATAATTCATACTGGAGAAAAACC
CTACAAATGTGAAGAATGTGGCAAAGCTTTTAAAAAGTCCTCAAACCTTACGAATCATAAGATAATTCATACTGGAGAGAAACCCTACAA
ATGTGAAGAATGTGGAAAAGCTTTTAACCAGTCCTCAACTCTTACTAGACATAAGATAATTCATACTGGAGAGAAACTCTACAAATGTGA
AGAATGTGGCAAAGCTTTTAACCGGTCCTCAAACCTTACTAAACATAAGATAGTTCATACTGGAGAGAAACCCTACAAATGTGAAGAATG
TGGCAAAGCTTTTAAACAGTCCTCAAACCTTACTAATCACAAGAAAATTCATACTGGAGAGAAACCCTACAAATGTGGAGAATGTGGCAA
AGCCTTTACCCTATCTTCACACCTTACTACACATAAGAGGATTCATACTGGTGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTT
TAGTGTATTTTCAACCCTTACTAAACATAAGATAATTCATACTGAAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCTTTTAACCG
GTCCTCACACCTTACTAATCATAAGGTAATTCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTTACCAAGTCCTC
AACTCTTACTTATCATAAGGTAATTCATACTGGAAAGAAACCCTACAAATGTGAAGAATGTGGTAAAGCCTTTAGTATATTCTCAATCCT
TACTAAACATAAAGTAATTCATACTGAAGACAAACCCTACAAATGTGAAGAATGTGGCAAAACTTTTAACTACTCCTCAAATTTTACTAA
TCATAAAAAAATTCATACTGGAGAGAAACCCTATAAGTGTGAAGAATGTGGCAAAAGCTTTATTCTGTCCTCTCATCTTACTACACATAA
GATAATTCATACTGGAGAGAAACCCTACAAATGTAAAGAATGTGGCAAAGCTTTTAACCAGTCCTCAACCCTTATGAAACATAAGATAAT
TCATACTGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTCCCCAAACCTTACTAAACATAAGAGAATTCATAC
CAAAGAGAAACCCTACAAATGTAAATAATGTGTCAAATCCTTTAGTGTATTTTCAACTTTTATTAAAACACAAGATAATTCATACTGGAG
AGAAATCCTACAAATGTGATAAATGTGGCAAAGCCTTTAACTGGCTCTTAATCCTTATGAAACAAAAGATAATTCATACTAGAGAGAAAC
CCTACAAATGTAAAGAATGTGGCAAAGCATTTAACTGGTCCCTAAATCTTACTAAACATAAAAAAACTTAAACTGGAGAGAAACTACAAA
GCTGGAAGACATCACAGTAATTCTGACAACACCTCAAACTTTTCTAAACATAAAATAAATCATACTGGTGAGGAACTTTAAAAATGCGAA
AAATGTGACAAAATCTTTAAATGATTGTCACACTTGATTGTAGGTAAGATAATTCTTACTAGAAAAACTCTTACAAGTGTGAAGAATGTG
GCAAAATTTTTAATGAATACTCACACCTTATTGCCAGGAAAGCATTTATACTTGAGAAAAATTGTACCAATATAAAGACTGTGAAAAAGC
CATTAATGTCTGCTCACATCTTACTCAACATCAGAGAGTACTTAAAAAAAGTATTATAAATTTAATTACTGTCAAAAAGTATTTCAGAAA
ATATAAGCTTTTAAAGTATTTATTTTGAAGACAAACATTACAAATAAAAGAGGATTGTAATACCTTTATTTGTATCACAGATCTTATTGT
ACACATTTTGTACTAGAGAAAACCCTGAAGCAGTTACTTAAACTTTGTTCAACATCAGGGAATTCAGATTGGAGAAAAACCCTGCAAATG
TAATAAATTTGAAAAAAAAGTTTTCCAAAACTACAACTTAGACAACACCAGAGGGTTCATACTGAGATATATTTTTGCAGATGCAGTATA
TATTTAAAACATTTAATCCAAAATAAGTCTATGTAAATATCAGAGAATTCACAGTGGAAATATCTAAGGTAGGGCCGGGCATGGTGGCTC
ACGCCTGTAATGCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCATGAGGTCAACAGATTGAGACCATCCTGGTCAACATGGTAAAACCC
TGTCTCTACTAAAAATACAAAAATTAGCTGGGCGTGGCGGCACGTGCCTGTAGTCTCAGCTACTTGGGACGCTGAGGCAGGAAAATCCGT
TGAACCCAGGAGGCAGAGGTTGTAGTGAGCCGAGATTGCACCACTGCACTCCAGCCGGGTGACAGAGTGAGACTCCATCTCAAAAACAAA
CAAACTAAGGTATGGATGCTTCAGACATTACACTATATCAAAGTGCTGACTGTTAAAAATGATCCCAAACTAACGGTAGATAAATTTATT
TGTACATAACTTTAAAAGGAGTAGAAGATTTTTTGGAAGTTTGTAATTACATTCAAAGTATACTTTTTTTGTTTGTTTGTTTTCCTTGAG
ACAGAGTCTCTCTCTGTCGTCCAGGCTGGAGTGCAGTGGCACAATCTCAGCTCGCTGCAACCTCTGCCTCCTGGGTTCAAGCAATTCTCC
TGCCTCAGCCTACTGAGTAGCTGAGATTACAGGTGCACACCACCACGTCCGGCTGACTTTTGTATTTTTAGTAGGGACGGGGTTTCACCA
TATTGGTCAGGGTAGTCTTGAACTCCTGACCTCATGCTCTGCCCAGCTTGGCTTCCCAAAGTGCTGTGATTACAGGCTTAAGCCACAGCG
CCCGGCCCAAAGTGTTCTTTTTTCCTTGAAAAGAAGTACAGATTTTTTAAAAAGCTAATATTGCTGTGATTCAACTCTCTAGTTACTTGA
TGCTATTTCTTCATTTCTATTGTATTCACATGTGAAAGCATGTGATCAGTTGTCACGGCATCAAAGATAGGAGAGTTTCTTTTTTTTTAG
GTGGGCATTATTTATGACCTTTTCTTTGGAAGAGTAAGGACATTAAAATGTAACATGCATGATGAAAATCTAAGTGGAGATGGTATTTGT
GGTTAATTATGATATTGAGTGGTGCATGAGGTAGGTGTTTAGAGTAATATTCTTTTGCATTATAGTAAGAACATTTAAGTTTTGTTAAAA

>16714_16714_3_CHST8-ZNF708_CHST8_chr19_34180297_ENST00000438847_ZNF708_chr19_21477541_ENST00000356929_length(amino acids)=536AA_BP=50
MSQPRMTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPAMCSHFAKDLRPEQYIKNSFQQVILRRYGKCGYQKGCKSVDE
HKLHKGGHKGLNRCVTTTQSKIVQCDKYVKVFHKYSNAKRHKIRHTGKNPFKCKECGKSFCMLSQLTQHEIIHTGEKPYKCEECGKAFKK
SSNLTNHKIIHTGEKPYKCEECGKAFNQSSTLTRHKIIHTGEKLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTN
HKKIHTGEKPYKCGECGKAFTLSSHLTTHKRIHTGEKPYKCEECGKAFSVFSTLTKHKIIHTEEKPYKCEECGKAFNRSSHLTNHKVIHT
GEKPYKCEECGKAFTKSSTLTYHKVIHTGKKPYKCEECGKAFSIFSILTKHKVIHTEDKPYKCEECGKTFNYSSNFTNHKKIHTGEKPYK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHST8-ZNF708


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHST8-ZNF708


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHST8-ZNF708


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource