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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CHST9-BBS9 (FusionGDB2 ID:16716)

Fusion Gene Summary for CHST9-BBS9

check button Fusion gene summary
Fusion gene informationFusion gene name: CHST9-BBS9
Fusion gene ID: 16716
HgeneTgene
Gene symbol

CHST9

BBS9

Gene ID

83539

27241

Gene namecarbohydrate sulfotransferase 9Bardet-Biedl syndrome 9
SynonymsGALNAC4ST-2|GalNAc4ST2B1|C18|D1|PTHB1
Cytomap

18q11.2

7p14.3

Type of geneprotein-codingprotein-coding
Descriptioncarbohydrate sulfotransferase 9GalNAc-4-sulfotransferase 2N-acetylgalactosamine 4-O-sulfotransferase 2carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9galNAc-4-O-sulfotransferase 2protein PTHB1PTH-responsive osteosarcoma B1 proteinbardet-Biedl syndrome 9 proteinparathyroid hormone-responsive B1 gene protein
Modification date2020031320200320
UniProtAcc

Q7L1S5

Q3SYG4

Ensembl transtripts involved in fusion geneENST00000284224, ENST00000580774, 
ENST00000581714, 		ENST00000425508, 
ENST00000482941, ENST00000242067, 
ENST00000350941, ENST00000354265, 
ENST00000355070, ENST00000396127, 
Fusion gene scores* DoF score6 X 5 X 4=12014 X 17 X 8=1904
# samples 719
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1904*10)=-3.324962154977
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CHST9 [Title/Abstract] AND BBS9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCHST9(24722653)-BBS9(33388680), # samples:1
Anticipated loss of major functional domain due to fusion event.CHST9-BBS9 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCHST9

GO:0006790

sulfur compound metabolic process

11445554


check buttonFusion gene breakpoints across CHST9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BBS9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-91-8499-01ACHST9chr18

24722653

-BBS9chr7

33388680

+


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Fusion Gene ORF analysis for CHST9-BBS9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000284224ENST00000425508CHST9chr18

24722653

-BBS9chr7

33388680

+
5CDS-intronENST00000284224ENST00000482941CHST9chr18

24722653

-BBS9chr7

33388680

+
5CDS-intronENST00000580774ENST00000425508CHST9chr18

24722653

-BBS9chr7

33388680

+
5CDS-intronENST00000580774ENST00000482941CHST9chr18

24722653

-BBS9chr7

33388680

+
5CDS-intronENST00000581714ENST00000425508CHST9chr18

24722653

-BBS9chr7

33388680

+
5CDS-intronENST00000581714ENST00000482941CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000284224ENST00000242067CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000284224ENST00000350941CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000284224ENST00000354265CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000284224ENST00000355070CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000284224ENST00000396127CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000580774ENST00000242067CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000580774ENST00000350941CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000580774ENST00000354265CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000580774ENST00000355070CHST9chr18

24722653

-BBS9chr7

33388680

+
Frame-shiftENST00000580774ENST00000396127CHST9chr18

24722653

-BBS9chr7

33388680

+
In-frameENST00000581714ENST00000242067CHST9chr18

24722653

-BBS9chr7

33388680

+
In-frameENST00000581714ENST00000350941CHST9chr18

24722653

-BBS9chr7

33388680

+
In-frameENST00000581714ENST00000354265CHST9chr18

24722653

-BBS9chr7

33388680

+
In-frameENST00000581714ENST00000355070CHST9chr18

24722653

-BBS9chr7

33388680

+
In-frameENST00000581714ENST00000396127CHST9chr18

24722653

-BBS9chr7

33388680

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000581714CHST9chr1824722653-ENST00000242067BBS9chr733388680+25273502961684462
ENST00000581714CHST9chr1824722653-ENST00000355070BBS9chr733388680+25123502961669457
ENST00000581714CHST9chr1824722653-ENST00000350941BBS9chr733388680+24073502961564422
ENST00000581714CHST9chr1824722653-ENST00000354265BBS9chr733388680+24223502961579427
ENST00000581714CHST9chr1824722653-ENST00000396127BBS9chr733388680+24223502961579427

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000581714ENST00000242067CHST9chr1824722653-BBS9chr733388680+0.0006918090.9993082
ENST00000581714ENST00000355070CHST9chr1824722653-BBS9chr733388680+0.0023446540.9976553
ENST00000581714ENST00000350941CHST9chr1824722653-BBS9chr733388680+0.0006423470.99935764
ENST00000581714ENST00000354265CHST9chr1824722653-BBS9chr733388680+0.0006231470.99937683
ENST00000581714ENST00000396127CHST9chr1824722653-BBS9chr733388680+0.0006669410.9993331

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Fusion Genomic Features for CHST9-BBS9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CHST9chr1824722652-BBS9chr733388679+1.81E-050.999982
CHST9chr1824722652-BBS9chr733388679+1.81E-050.999982

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CHST9-BBS9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:24722653/chr7:33388680)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CHST9

Q7L1S5

BBS9

Q3SYG4

FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. {ECO:0000269|PubMed:17574030, ECO:0000269|PubMed:22072986}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHST9chr18:24722653chr7:33388680ENST00000284224-261_1240444.0Topological domainCytoplasmic
HgeneCHST9chr18:24722653chr7:33388680ENST00000580774-251_124075.0Topological domainCytoplasmic
HgeneCHST9chr18:24722653chr7:33388680ENST00000581714-151_1240444.0Topological domainCytoplasmic
HgeneCHST9chr18:24722653chr7:33388680ENST00000284224-2613_3340444.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCHST9chr18:24722653chr7:33388680ENST00000580774-2513_334075.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneCHST9chr18:24722653chr7:33388680ENST00000581714-1513_3340444.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneBBS9chr18:24722653chr7:33388680ENST000004255080101_4070311.0RegionSeven-bladed beta-propeller

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCHST9chr18:24722653chr7:33388680ENST00000284224-26220_22640444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24722653chr7:33388680ENST00000284224-26280_28840444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24722653chr7:33388680ENST00000580774-25220_2264075.0Nucleotide bindingPAPS
HgeneCHST9chr18:24722653chr7:33388680ENST00000580774-25280_2884075.0Nucleotide bindingPAPS
HgeneCHST9chr18:24722653chr7:33388680ENST00000581714-15220_22640444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24722653chr7:33388680ENST00000581714-15280_28840444.0Nucleotide bindingPAPS
HgeneCHST9chr18:24722653chr7:33388680ENST00000284224-2634_44340444.0Topological domainLumenal
HgeneCHST9chr18:24722653chr7:33388680ENST00000580774-2534_4434075.0Topological domainLumenal
HgeneCHST9chr18:24722653chr7:33388680ENST00000581714-1534_44340444.0Topological domainLumenal
TgeneBBS9chr18:24722653chr7:33388680ENST0000024206711231_407443888.0RegionSeven-bladed beta-propeller
TgeneBBS9chr18:24722653chr7:33388680ENST0000035094111211_407443848.0RegionSeven-bladed beta-propeller
TgeneBBS9chr18:24722653chr7:33388680ENST0000039612711221_407443853.0RegionSeven-bladed beta-propeller


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Fusion Gene Sequence for CHST9-BBS9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16716_16716_1_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000242067_length(transcript)=2527nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGTCACACTGC
AGAACAGAGTGATATTGCAAAAAGCCAAATTATCAGTCTACGTGCAACCACCATTAGAATTGACTTGTGATCAGTTCACCTTTGAATTTA
TGACACCAGATTTGACTAGAACAGTAAGCTTTTCTGTTTATCTGAAAAGAAGTTATACACCATCAGAATTGGAAGGAAATGCTGTTGTTT
CTTATTCCAGACCAACAGATCGAAATCCTGATGGCATTCCGCGAGTTATCCAATGTAAATTTAGACTTCCCCTAAAGTTAATTTGCCTAC
CAGGTCAGCCTTCAAAAACTGCAAGCCACAAAATTACTATTGATACCAACAAATCTCCAGTCAGTCTTCTTAGTCTCTTCCCAGGTTTTG
CCAGTCAGTCAGATGATGATCAGGTGAATGTAATGGGTTTTCACTTCTTAGGAGGTGCTCGAATTACTGTTCTTGCTTCCAAAACTTCTC
AACGATATCGCATTCAGAGTGAACAATTTGAAGATCTTTGGCTCATAACCAATGAGCTTATTCTTCGCCTTCAAGAATATTTTGAAAAAC
AGGGAGTCAAAGATTTTGCATGTTCTTTTTCGGGATCTATACCCCTTCAAGAATATTTTGAGTTGATTGATCATCATTTTGAGCTACGGA
TAAATGGTGAAAAATTAGAAGAACTCTTATCTGAGAGAGCTGTACAATTTCGGGCCATTCAACGCCGGCTACTAGCAAGATTCAAAGATA
AAACTCCTGCCCCTCTTCAACACCTGGACACCTTGTTAGATGGAACCTACAAGCAGGTAATTGCTCTAGCAGATGCAGTGGAGGAAAACC
AAGGCAATCTGTTCCAGTCATTCACCAGGCTGAAGAGTGCCACCCATTTGGTGATTCTGCTGATCGCGCTGTGGCAGAAGCTTAGTGCTG
ACCAGGTTGCTATTCTGGAAGCGGCATTTCTGCCGCTACAAGAAGACACTCAAGAATTGGGCTGGGAAGAAACGGTGGATGCCGCCATTT
CCCACCTGTTGAAGACTTGCCTGTCGAAGAGTTCTAAGGAGCAGGCTTTGAACCTCAACAGCCAGCTGAACATACCCAAAGACACAAGCC
AACTGAAGAAACATATCACCTTGCTCTGCGATAGATTATCCAAAGGTGGCCGTCTCTGCCTAAGTACCGATGCAGCAGCCCCACAGACCA
TGGTCATGCCAGGTGGTTGTACTACAATCCCAGAGTCAGACCTAGAAGAAAGATCAGTAGAACAAGACTCTACAGAACTGTTTACCAACC
ACAGACATCTCACTGCAGAGACACCCAGGCCTGAAGTTTCACCCCTCCAAGGAGTCTCGGAATAATTCAAGTAGAGTTGTTTGGTTGAGA
GGAACATCCCCATCTCAAGGCCGAACCTGTGTGAACCTCATGCCAAGCACAGATATAGGGCTGGCGCAGGTGCTTCCTAAAGCTCACCTT
CCTGGAGATGACATGCATAGAAAGAGGGGTTGGGACTTTTTACTTCACTAGGAGAACTTGTAACACCATGGGGAAGTCAGCTGAAACTTG
TCTTGTTTTGCCAGGAAAGGAAGTAGTTGCCTTTGGTCATCCATCTGCTAATAGTCACAGAATACAGTGAAATGACATAGTTTTGGGTTA
GATTTTATAATGCAAAGATTCAGATCCAAAATAATTTCATACCCCATTTTTTCACAGAATTCTTATATAGTAAATGTATCAAGTTTAATA
AAGCATCTCATTGTCAAATAATATCTTGGATTTTATTTATAATTAGAGGGATTTATGAGTGATTGCTCTACATTATTTCTTCAAAGGAAA
GGAAAGGAATTGAAGACTTTGCTACTCTCTGGTAAGACTTGAATGTGATTATTTTATAAATAAAAGAACCACTATGAAACTTTCATGTGA
TTTGTTCTATTAAGCTAAACGTGGAAGAAGGGAAGTTTTCTAGTATTGTATGAAAATGTTTAAATATTTTCAAGGAAGCTAGTACATTAA
CATCCCCTTTTCATTACCCCATTGGGTGGCACCTTTTAAAAATCCAGGTTATTAAAGGATTCACACTTTATTACAGTTAAAATTTAAGGT
TTTTATGTGTAAGAAGTGAAAGAAACTTTGCTAATTTCAAGTTCGAATTACAGTTGTGAGATTGATTTATTTAAATAAAAATATGCCTTT

>16716_16716_1_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000242067_length(amino acids)=462AA_BP=18
MGYSSSCICKSGLKNNIQVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMTPDLTRTVSFSVYLKRSYTPSELEGNAVVSYSRPTDRN
PDGIPRVIQCKFRLPLKLICLPGQPSKTASHKITIDTNKSPVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQ
FEDLWLITNELILRLQEYFEKQGVKDFACSFSGSIPLQEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHL
DTLLDGTYKQVIALADAVEENQGNLFQSFTRLKSATHLVILLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLS
KSSKEQALNLNSQLNIPKDTSQLKKHITLLCDRLSKGGRLCLSTDAAAPQTMVMPGGCTTIPESDLEERSVEQDSTELFTNHRHLTAETP

--------------------------------------------------------------
>16716_16716_2_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000350941_length(transcript)=2407nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGTCACACTGC
AGAACAGAGTGATATTGCAAAAAGCCAAATTATCAGTCTACGTGCAACCACCATTAGAATTGACTTGTGATCAGTTCACCTTTGAATTTA
TGAGCATTCCGCGAGTTATCCAATGTAAATTTAGACTTCCCCTAAAGTTAATTTGCCTACCAGGTCAGCCTTCAAAAACTGCAAGCCACA
AAATTACTATTGATACCAACAAATCTCCAGTCAGTCTTCTTAGTCTCTTCCCAGGTTTTGCCAGTCAGTCAGATGATGATCAGGTGAATG
TAATGGGTTTTCACTTCTTAGGAGGTGCTCGAATTACTGTTCTTGCTTCCAAAACTTCTCAACGATATCGCATTCAGAGTGAACAATTTG
AAGATCTTTGGCTCATAACCAATGAGCTTATTCTTCGCCTTCAAGAATATTTTGAAAAACAGGGAGTCAAAGATTTTGCATGTTCTTTTT
CGGGATCTATACCCCTTCAAGAATATTTTGAGTTGATTGATCATCATTTTGAGCTACGGATAAATGGTGAAAAATTAGAAGAACTCTTAT
CTGAGAGAGCTGTACAATTTCGGGCCATTCAACGCCGGCTACTAGCAAGATTCAAAGATAAAACTCCTGCCCCTCTTCAACACCTGGACA
CCTTGTTAGATGGAACCTACAAGCAGGTAATTGCTCTAGCAGATGCAGTGGAGGAAAACCAAGGCAATCTGTTCCAGTCATTCACCAGGC
TGAAGAGTGCCACCCATTTGGTGATTCTGCTGATCGCGCTGTGGCAGAAGCTTAGTGCTGACCAGGTTGCTATTCTGGAAGCGGCATTTC
TGCCGCTACAAGAAGACACTCAAGAATTGGGCTGGGAAGAAACGGTGGATGCCGCCATTTCCCACCTGTTGAAGACTTGCCTGTCGAAGA
GTTCTAAGGAGCAGGCTTTGAACCTCAACAGCCAGCTGAACATACCCAAAGACACAAGCCAACTGAAGAAACATATCACCTTGCTCTGCG
ATAGATTATCCAAAGGTGGCCGTCTCTGCCTAAGTACCGATGCAGCAGCCCCACAGACCATGGTCATGCCAGGTGGTTGTACTACAATCC
CAGAGTCAGACCTAGAAGAAAGATCAGTAGAACAAGACTCTACAGAACTGTTTACCAACCACAGACATCTCACTGCAGAGACACCCAGGC
CTGAAGTTTCACCCCTCCAAGGAGTCTCGGAATAATTCAAGTAGAGTTGTTTGGTTGAGAGGAACATCCCCATCTCAAGGCCGAACCTGT
GTGAACCTCATGCCAAGCACAGATATAGGGCTGGCGCAGGTGCTTCCTAAAGCTCACCTTCCTGGAGATGACATGCATAGAAAGAGGGGT
TGGGACTTTTTACTTCACTAGGAGAACTTGTAACACCATGGGGAAGTCAGCTGAAACTTGTCTTGTTTTGCCAGGAAAGGAAGTAGTTGC
CTTTGGTCATCCATCTGCTAATAGTCACAGAATACAGTGAAATGACATAGTTTTGGGTTAGATTTTATAATGCAAAGATTCAGATCCAAA
ATAATTTCATACCCCATTTTTTCACAGAATTCTTATATAGTAAATGTATCAAGTTTAATAAAGCATCTCATTGTCAAATAATATCTTGGA
TTTTATTTATAATTAGAGGGATTTATGAGTGATTGCTCTACATTATTTCTTCAAAGGAAAGGAAAGGAATTGAAGACTTTGCTACTCTCT
GGTAAGACTTGAATGTGATTATTTTATAAATAAAAGAACCACTATGAAACTTTCATGTGATTTGTTCTATTAAGCTAAACGTGGAAGAAG
GGAAGTTTTCTAGTATTGTATGAAAATGTTTAAATATTTTCAAGGAAGCTAGTACATTAACATCCCCTTTTCATTACCCCATTGGGTGGC
ACCTTTTAAAAATCCAGGTTATTAAAGGATTCACACTTTATTACAGTTAAAATTTAAGGTTTTTATGTGTAAGAAGTGAAAGAAACTTTG

>16716_16716_2_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000350941_length(amino acids)=422AA_BP=18
MGYSSSCICKSGLKNNIQVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMSIPRVIQCKFRLPLKLICLPGQPSKTASHKITIDTNKS
PVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQFEDLWLITNELILRLQEYFEKQGVKDFACSFSGSIPLQEY
FELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQGNLFQSFTRLKSATHLVI
LLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLSKSSKEQALNLNSQLNIPKDTSQLKKHITLLCDRLSKGGRL

--------------------------------------------------------------
>16716_16716_3_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000354265_length(transcript)=2422nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGTCACACTGC
AGAACAGAGTGATATTGCAAAAAGCCAAATTATCAGTCTACGTGCAACCACCATTAGAATTGACTTGTGATCAGTTCACCTTTGAATTTA
TGAGTCTGAATGTTTTAGGCATTCCGCGAGTTATCCAATGTAAATTTAGACTTCCCCTAAAGTTAATTTGCCTACCAGGTCAGCCTTCAA
AAACTGCAAGCCACAAAATTACTATTGATACCAACAAATCTCCAGTCAGTCTTCTTAGTCTCTTCCCAGGTTTTGCCAGTCAGTCAGATG
ATGATCAGGTGAATGTAATGGGTTTTCACTTCTTAGGAGGTGCTCGAATTACTGTTCTTGCTTCCAAAACTTCTCAACGATATCGCATTC
AGAGTGAACAATTTGAAGATCTTTGGCTCATAACCAATGAGCTTATTCTTCGCCTTCAAGAATATTTTGAAAAACAGGGAGTCAAAGATT
TTGCATGTTCTTTTTCGGGATCTATACCCCTTCAAGAATATTTTGAGTTGATTGATCATCATTTTGAGCTACGGATAAATGGTGAAAAAT
TAGAAGAACTCTTATCTGAGAGAGCTGTACAATTTCGGGCCATTCAACGCCGGCTACTAGCAAGATTCAAAGATAAAACTCCTGCCCCTC
TTCAACACCTGGACACCTTGTTAGATGGAACCTACAAGCAGGTAATTGCTCTAGCAGATGCAGTGGAGGAAAACCAAGGCAATCTGTTCC
AGTCATTCACCAGGCTGAAGAGTGCCACCCATTTGGTGATTCTGCTGATCGCGCTGTGGCAGAAGCTTAGTGCTGACCAGGTTGCTATTC
TGGAAGCGGCATTTCTGCCGCTACAAGAAGACACTCAAGAATTGGGCTGGGAAGAAACGGTGGATGCCGCCATTTCCCACCTGTTGAAGA
CTTGCCTGTCGAAGAGTTCTAAGGAGCAGGCTTTGAACCTCAACAGCCAGCTGAACATACCCAAAGACACAAGCCAACTGAAGAAACATA
TCACCTTGCTCTGCGATAGATTATCCAAAGGTGGCCGTCTCTGCCTAAGTACCGATGCAGCAGCCCCACAGACCATGGTCATGCCAGGTG
GTTGTACTACAATCCCAGAGTCAGACCTAGAAGAAAGATCAGTAGAACAAGACTCTACAGAACTGTTTACCAACCACAGACATCTCACTG
CAGAGACACCCAGGCCTGAAGTTTCACCCCTCCAAGGAGTCTCGGAATAATTCAAGTAGAGTTGTTTGGTTGAGAGGAACATCCCCATCT
CAAGGCCGAACCTGTGTGAACCTCATGCCAAGCACAGATATAGGGCTGGCGCAGGTGCTTCCTAAAGCTCACCTTCCTGGAGATGACATG
CATAGAAAGAGGGGTTGGGACTTTTTACTTCACTAGGAGAACTTGTAACACCATGGGGAAGTCAGCTGAAACTTGTCTTGTTTTGCCAGG
AAAGGAAGTAGTTGCCTTTGGTCATCCATCTGCTAATAGTCACAGAATACAGTGAAATGACATAGTTTTGGGTTAGATTTTATAATGCAA
AGATTCAGATCCAAAATAATTTCATACCCCATTTTTTCACAGAATTCTTATATAGTAAATGTATCAAGTTTAATAAAGCATCTCATTGTC
AAATAATATCTTGGATTTTATTTATAATTAGAGGGATTTATGAGTGATTGCTCTACATTATTTCTTCAAAGGAAAGGAAAGGAATTGAAG
ACTTTGCTACTCTCTGGTAAGACTTGAATGTGATTATTTTATAAATAAAAGAACCACTATGAAACTTTCATGTGATTTGTTCTATTAAGC
TAAACGTGGAAGAAGGGAAGTTTTCTAGTATTGTATGAAAATGTTTAAATATTTTCAAGGAAGCTAGTACATTAACATCCCCTTTTCATT
ACCCCATTGGGTGGCACCTTTTAAAAATCCAGGTTATTAAAGGATTCACACTTTATTACAGTTAAAATTTAAGGTTTTTATGTGTAAGAA

>16716_16716_3_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000354265_length(amino acids)=427AA_BP=18
MGYSSSCICKSGLKNNIQVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMSLNVLGIPRVIQCKFRLPLKLICLPGQPSKTASHKITI
DTNKSPVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQFEDLWLITNELILRLQEYFEKQGVKDFACSFSGSI
PLQEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQGNLFQSFTRLKSA
THLVILLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLSKSSKEQALNLNSQLNIPKDTSQLKKHITLLCDRLS

--------------------------------------------------------------
>16716_16716_4_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000355070_length(transcript)=2512nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGTCACACTGC
AGAACAGAGTGATATTGCAAAAAGCCAAATTATCAGTCTACGTGCAACCACCATTAGAATTGACTTGTGATCAGTTCACCTTTGAATTTA
TGACACCAGATTTGACTAGAACAGTAAGCTTTTCTGTTTATCTGAAAAGAAGTTATACACCATCAGAATTGGAAGGAAATGCTGTTGTTT
CTTATTCCAGACCAACAGGCATTCCGCGAGTTATCCAATGTAAATTTAGACTTCCCCTAAAGTTAATTTGCCTACCAGGTCAGCCTTCAA
AAACTGCAAGCCACAAAATTACTATTGATACCAACAAATCTCCAGTCAGTCTTCTTAGTCTCTTCCCAGGTTTTGCCAGTCAGTCAGATG
ATGATCAGGTGAATGTAATGGGTTTTCACTTCTTAGGAGGTGCTCGAATTACTGTTCTTGCTTCCAAAACTTCTCAACGATATCGCATTC
AGAGTGAACAATTTGAAGATCTTTGGCTCATAACCAATGAGCTTATTCTTCGCCTTCAAGAATATTTTGAAAAACAGGGAGTCAAAGATT
TTGCATGTTCTTTTTCGGGATCTATACCCCTTCAAGAATATTTTGAGTTGATTGATCATCATTTTGAGCTACGGATAAATGGTGAAAAAT
TAGAAGAACTCTTATCTGAGAGAGCTGTACAATTTCGGGCCATTCAACGCCGGCTACTAGCAAGATTCAAAGATAAAACTCCTGCCCCTC
TTCAACACCTGGACACCTTGTTAGATGGAACCTACAAGCAGGTAATTGCTCTAGCAGATGCAGTGGAGGAAAACCAAGGCAATCTGTTCC
AGTCATTCACCAGGCTGAAGAGTGCCACCCATTTGGTGATTCTGCTGATCGCGCTGTGGCAGAAGCTTAGTGCTGACCAGGTTGCTATTC
TGGAAGCGGCATTTCTGCCGCTACAAGAAGACACTCAAGAATTGGGCTGGGAAGAAACGGTGGATGCCGCCATTTCCCACCTGTTGAAGA
CTTGCCTGTCGAAGAGTTCTAAGGAGCAGGCTTTGAACCTCAACAGCCAGCTGAACATACCCAAAGACACAAGCCAACTGAAGAAACATA
TCACCTTGCTCTGCGATAGATTATCCAAAGGTGGCCGTCTCTGCCTAAGTACCGATGCAGCAGCCCCACAGACCATGGTCATGCCAGGTG
GTTGTACTACAATCCCAGAGTCAGACCTAGAAGAAAGATCAGTAGAACAAGACTCTACAGAACTGTTTACCAACCACAGACATCTCACTG
CAGAGACACCCAGGCCTGAAGTTTCACCCCTCCAAGGAGTCTCGGAATAATTCAAGTAGAGTTGTTTGGTTGAGAGGAACATCCCCATCT
CAAGGCCGAACCTGTGTGAACCTCATGCCAAGCACAGATATAGGGCTGGCGCAGGTGCTTCCTAAAGCTCACCTTCCTGGAGATGACATG
CATAGAAAGAGGGGTTGGGACTTTTTACTTCACTAGGAGAACTTGTAACACCATGGGGAAGTCAGCTGAAACTTGTCTTGTTTTGCCAGG
AAAGGAAGTAGTTGCCTTTGGTCATCCATCTGCTAATAGTCACAGAATACAGTGAAATGACATAGTTTTGGGTTAGATTTTATAATGCAA
AGATTCAGATCCAAAATAATTTCATACCCCATTTTTTCACAGAATTCTTATATAGTAAATGTATCAAGTTTAATAAAGCATCTCATTGTC
AAATAATATCTTGGATTTTATTTATAATTAGAGGGATTTATGAGTGATTGCTCTACATTATTTCTTCAAAGGAAAGGAAAGGAATTGAAG
ACTTTGCTACTCTCTGGTAAGACTTGAATGTGATTATTTTATAAATAAAAGAACCACTATGAAACTTTCATGTGATTTGTTCTATTAAGC
TAAACGTGGAAGAAGGGAAGTTTTCTAGTATTGTATGAAAATGTTTAAATATTTTCAAGGAAGCTAGTACATTAACATCCCCTTTTCATT
ACCCCATTGGGTGGCACCTTTTAAAAATCCAGGTTATTAAAGGATTCACACTTTATTACAGTTAAAATTTAAGGTTTTTATGTGTAAGAA

>16716_16716_4_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000355070_length(amino acids)=457AA_BP=18
MGYSSSCICKSGLKNNIQVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMTPDLTRTVSFSVYLKRSYTPSELEGNAVVSYSRPTGIP
RVIQCKFRLPLKLICLPGQPSKTASHKITIDTNKSPVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQFEDLW
LITNELILRLQEYFEKQGVKDFACSFSGSIPLQEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHLDTLLD
GTYKQVIALADAVEENQGNLFQSFTRLKSATHLVILLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLSKSSKE
QALNLNSQLNIPKDTSQLKKHITLLCDRLSKGGRLCLSTDAAAPQTMVMPGGCTTIPESDLEERSVEQDSTELFTNHRHLTAETPRPEVS

--------------------------------------------------------------
>16716_16716_5_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000396127_length(transcript)=2422nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGTCACACTGC
AGAACAGAGTGATATTGCAAAAAGCCAAATTATCAGTCTACGTGCAACCACCATTAGAATTGACTTGTGATCAGTTCACCTTTGAATTTA
TGAATCGAAATCCTGATGGCATTCCGCGAGTTATCCAATGTAAATTTAGACTTCCCCTAAAGTTAATTTGCCTACCAGGTCAGCCTTCAA
AAACTGCAAGCCACAAAATTACTATTGATACCAACAAATCTCCAGTCAGTCTTCTTAGTCTCTTCCCAGGTTTTGCCAGTCAGTCAGATG
ATGATCAGGTGAATGTAATGGGTTTTCACTTCTTAGGAGGTGCTCGAATTACTGTTCTTGCTTCCAAAACTTCTCAACGATATCGCATTC
AGAGTGAACAATTTGAAGATCTTTGGCTCATAACCAATGAGCTTATTCTTCGCCTTCAAGAATATTTTGAAAAACAGGGAGTCAAAGATT
TTGCATGTTCTTTTTCGGGATCTATACCCCTTCAAGAATATTTTGAGTTGATTGATCATCATTTTGAGCTACGGATAAATGGTGAAAAAT
TAGAAGAACTCTTATCTGAGAGAGCTGTACAATTTCGGGCCATTCAACGCCGGCTACTAGCAAGATTCAAAGATAAAACTCCTGCCCCTC
TTCAACACCTGGACACCTTGTTAGATGGAACCTACAAGCAGGTAATTGCTCTAGCAGATGCAGTGGAGGAAAACCAAGGCAATCTGTTCC
AGTCATTCACCAGGCTGAAGAGTGCCACCCATTTGGTGATTCTGCTGATCGCGCTGTGGCAGAAGCTTAGTGCTGACCAGGTTGCTATTC
TGGAAGCGGCATTTCTGCCGCTACAAGAAGACACTCAAGAATTGGGCTGGGAAGAAACGGTGGATGCCGCCATTTCCCACCTGTTGAAGA
CTTGCCTGTCGAAGAGTTCTAAGGAGCAGGCTTTGAACCTCAACAGCCAGCTGAACATACCCAAAGACACAAGCCAACTGAAGAAACATA
TCACCTTGCTCTGCGATAGATTATCCAAAGGTGGCCGTCTCTGCCTAAGTACCGATGCAGCAGCCCCACAGACCATGGTCATGCCAGGTG
GTTGTACTACAATCCCAGAGTCAGACCTAGAAGAAAGATCAGTAGAACAAGACTCTACAGAACTGTTTACCAACCACAGACATCTCACTG
CAGAGACACCCAGGCCTGAAGTTTCACCCCTCCAAGGAGTCTCGGAATAATTCAAGTAGAGTTGTTTGGTTGAGAGGAACATCCCCATCT
CAAGGCCGAACCTGTGTGAACCTCATGCCAAGCACAGATATAGGGCTGGCGCAGGTGCTTCCTAAAGCTCACCTTCCTGGAGATGACATG
CATAGAAAGAGGGGTTGGGACTTTTTACTTCACTAGGAGAACTTGTAACACCATGGGGAAGTCAGCTGAAACTTGTCTTGTTTTGCCAGG
AAAGGAAGTAGTTGCCTTTGGTCATCCATCTGCTAATAGTCACAGAATACAGTGAAATGACATAGTTTTGGGTTAGATTTTATAATGCAA
AGATTCAGATCCAAAATAATTTCATACCCCATTTTTTCACAGAATTCTTATATAGTAAATGTATCAAGTTTAATAAAGCATCTCATTGTC
AAATAATATCTTGGATTTTATTTATAATTAGAGGGATTTATGAGTGATTGCTCTACATTATTTCTTCAAAGGAAAGGAAAGGAATTGAAG
ACTTTGCTACTCTCTGGTAAGACTTGAATGTGATTATTTTATAAATAAAAGAACCACTATGAAACTTTCATGTGATTTGTTCTATTAAGC
TAAACGTGGAAGAAGGGAAGTTTTCTAGTATTGTATGAAAATGTTTAAATATTTTCAAGGAAGCTAGTACATTAACATCCCCTTTTCATT
ACCCCATTGGGTGGCACCTTTTAAAAATCCAGGTTATTAAAGGATTCACACTTTATTACAGTTAAAATTTAAGGTTTTTATGTGTAAGAA

>16716_16716_5_CHST9-BBS9_CHST9_chr18_24722653_ENST00000581714_BBS9_chr7_33388680_ENST00000396127_length(amino acids)=427AA_BP=18
MGYSSSCICKSGLKNNIQVTLQNRVILQKAKLSVYVQPPLELTCDQFTFEFMNRNPDGIPRVIQCKFRLPLKLICLPGQPSKTASHKITI
DTNKSPVSLLSLFPGFASQSDDDQVNVMGFHFLGGARITVLASKTSQRYRIQSEQFEDLWLITNELILRLQEYFEKQGVKDFACSFSGSI
PLQEYFELIDHHFELRINGEKLEELLSERAVQFRAIQRRLLARFKDKTPAPLQHLDTLLDGTYKQVIALADAVEENQGNLFQSFTRLKSA
THLVILLIALWQKLSADQVAILEAAFLPLQEDTQELGWEETVDAAISHLLKTCLSKSSKEQALNLNSQLNIPKDTSQLKKHITLLCDRLS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CHST9-BBS9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneBBS9chr18:24722653chr7:33388680ENST000002420671123685_765443.0888.0LZTL1
TgeneBBS9chr18:24722653chr7:33388680ENST000003509411121685_765443.0848.0LZTL1
TgeneBBS9chr18:24722653chr7:33388680ENST000003961271122685_765443.0853.0LZTL1
TgeneBBS9chr18:24722653chr7:33388680ENST00000425508010685_7650311.0LZTL1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CHST9-BBS9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CHST9-BBS9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource