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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
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Fusion gene:CHST9-ZNF675 (FusionGDB2 ID:16722)

Fusion Gene Summary for CHST9-ZNF675

Fusion gene summary

Fusion gene information	Fusion gene name: CHST9-ZNF675
	Fusion gene ID: 16722
		Hgene	Tgene
	Gene symbol	CHST9	ZNF675
	Gene ID	83539	171392
	Gene name	carbohydrate sulfotransferase 9	zinc finger protein 675
	Synonyms	GALNAC4ST-2\|GalNAc4ST2	TBZF\|TIZ
	Cytomap	18q11.2	19p12
	Type of gene	protein-coding	protein-coding
	Description	carbohydrate sulfotransferase 9GalNAc-4-sulfotransferase 2N-acetylgalactosamine 4-O-sulfotransferase 2carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9galNAc-4-O-sulfotransferase 2	zinc finger protein 675TRAF6 inhibitory zinc fingerTRAF6-binding zinc finger proteinTRAF6-inhibitory zinc finger protein
	Modification date	20200313	20200313
	UniProtAcc	Q7L1S5	.
	Ensembl transtripts involved in fusion gene	ENST00000284224, ENST00000580774, ENST00000581714,	ENST00000359788, ENST00000596211, ENST00000599168, ENST00000600313, ENST00000601010, ENST00000601935,
Fusion gene scores	* DoF score	6 X 5 X 4=120	5 X 5 X 4=100
	# samples	7	5
	** MAII score	log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHST9 [Title/Abstract] AND ZNF675 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHST9(24722653)-ZNF675(23845960), # samples:1
Anticipated loss of major functional domain due to fusion event.	CHST9-ZNF675 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CHST9-ZNF675 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CHST9-ZNF675 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHST9	GO:0006790	sulfur compound metabolic process	11445554
Tgene	ZNF675	GO:0000122	negative regulation of transcription by RNA polymerase II	11751921
Tgene	ZNF675	GO:0007249	I-kappaB kinase/NF-kappaB signaling	11751921
Tgene	ZNF675	GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway	11751921
Tgene	ZNF675	GO:0019221	cytokine-mediated signaling pathway	11751921
Tgene	ZNF675	GO:0032088	negative regulation of NF-kappaB transcription factor activity	11751921
Tgene	ZNF675	GO:0043508	negative regulation of JUN kinase activity	11751921
Tgene	ZNF675	GO:0045671	negative regulation of osteoclast differentiation	11751921\|11851921
Tgene	ZNF675	GO:0046329	negative regulation of JNK cascade	11751921
Tgene	ZNF675	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway	11751921
Tgene	ZNF675	GO:2000678	negative regulation of transcription regulatory region DNA binding	11751921

Fusion gene breakpoints across CHST9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ZNF675 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-70-6723-01A	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-

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Fusion Gene ORF analysis for CHST9-ZNF675

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000284224	ENST00000359788	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000284224	ENST00000596211	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000284224	ENST00000599168	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000284224	ENST00000600313	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000284224	ENST00000601010	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000284224	ENST00000601935	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000580774	ENST00000359788	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000580774	ENST00000596211	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000580774	ENST00000599168	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000580774	ENST00000600313	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000580774	ENST00000601010	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
Frame-shift	ENST00000580774	ENST00000601935	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
In-frame	ENST00000581714	ENST00000359788	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
In-frame	ENST00000581714	ENST00000596211	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
In-frame	ENST00000581714	ENST00000599168	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
In-frame	ENST00000581714	ENST00000600313	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
In-frame	ENST00000581714	ENST00000601010	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-
In-frame	ENST00000581714	ENST00000601935	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000581714	CHST9	chr18	24722653	-	ENST00000601935	ZNF675	chr19	23845960	-	1627	350	296	700	134
ENST00000581714	CHST9	chr18	24722653	-	ENST00000600313	ZNF675	chr19	23845960	-	711	350	296	703	135
ENST00000581714	CHST9	chr18	24722653	-	ENST00000596211	ZNF675	chr19	23845960	-	749	350	296	586	96
ENST00000581714	CHST9	chr18	24722653	-	ENST00000359788	ZNF675	chr19	23845960	-	2479	350	296	2053	585
ENST00000581714	CHST9	chr18	24722653	-	ENST00000601010	ZNF675	chr19	23845960	-	861	350	296	652	118
ENST00000581714	CHST9	chr18	24722653	-	ENST00000599168	ZNF675	chr19	23845960	-	752	350	296	580	94

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000581714	ENST00000601935	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-	0.42566732	0.5743327
ENST00000581714	ENST00000600313	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-	0.7093808	0.2906192
ENST00000581714	ENST00000596211	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-	0.76033247	0.23966753
ENST00000581714	ENST00000359788	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-	0.002497537	0.9975025
ENST00000581714	ENST00000601010	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-	0.83441836	0.16558166
ENST00000581714	ENST00000599168	CHST9	chr18	24722653	-	ZNF675	chr19	23845960	-	0.90201825	0.09798176

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Fusion Genomic Features for CHST9-ZNF675

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHST9-ZNF675

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:24722653/chr19:23845960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHST9 Q7L1S5	.
FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta. Isoform 2, but not isoform 1, is active toward chondroitin.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000284224

1_12

444.0

Topological domain

Cytoplasmic

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000580774

1_12

75.0

Topological domain

Cytoplasmic

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000581714

1_12

444.0

Topological domain

Cytoplasmic

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000284224

13_33

444.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000580774

13_33

75.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000581714

13_33

444.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

4_75

569.0

Domain

KRAB

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

144_166

569.0

Zinc finger

C2H2-type 1%3B degenerate

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

172_194

569.0

Zinc finger

C2H2-type 2%3B degenerate

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

200_222

569.0

Zinc finger

C2H2-type 3%3B degenerate

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

228_250

569.0

Zinc finger

C2H2-type 4%3B degenerate

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

256_278

569.0

Zinc finger

C2H2-type 5

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

284_306

569.0

Zinc finger

C2H2-type 6

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

312_334

569.0

Zinc finger

C2H2-type 7

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

340_362

569.0

Zinc finger

C2H2-type 8

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

368_390

569.0

Zinc finger

C2H2-type 9

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

396_418

569.0

Zinc finger

C2H2-type 10

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

424_446

569.0

Zinc finger

C2H2-type 11

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

452_474

569.0

Zinc finger

C2H2-type 12

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

480_502

569.0

Zinc finger

C2H2-type 13

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

508_530

569.0

Zinc finger

C2H2-type 14

Tgene

ZNF675

chr18:24722653

chr19:23845960

ENST00000359788

536_558

569.0

Zinc finger

C2H2-type 15

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000284224

220_226

444.0

Nucleotide binding

PAPS

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000284224

280_288

444.0

Nucleotide binding

PAPS

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000580774

220_226

75.0

Nucleotide binding

PAPS

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000580774

280_288

75.0

Nucleotide binding

PAPS

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000581714

220_226

444.0

Nucleotide binding

PAPS

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000581714

280_288

444.0

Nucleotide binding

PAPS

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000284224

34_443

444.0

Topological domain

Lumenal

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000580774

34_443

75.0

Topological domain

Lumenal

Hgene

CHST9

chr18:24722653

chr19:23845960

ENST00000581714

34_443

444.0

Topological domain

Lumenal

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Fusion Gene Sequence for CHST9-ZNF675

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16722_16722_1_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000359788_length(transcript)=2479nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGACTGTTGA
CATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTATATAAAAATGTGATTTTAG
AGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTG
TGAAGAGACATGAGATGGTGAATGAACCCCCAGTAATGTGTTCTCATTTTGCCCAAGAGTTTTGGCCAGAGCAGAACATAAAAGATTCTT
TTGAAAAAGTGACACTGAGAAGATATGAAAAATGTGGAAATGATAATTTTCAGTTAAAAGGCTGTAAAAGTGTGGATGAATGTAAGTTGC
ACAAGGGAGGTTATAATGGACTTAACCAATGTTTACCAACTATGCAGAGCAAAATGTTTCAATGTGATAAATATGTGAAAGTCTTTAATA
AATTTTCACATTCAGATAGACATAAGATAAAACATATGGAAAATAAACCTTTCAAATGTAAAGAATGTGGCAGATCATTTTGCATGCTTT
CACACCTAACTCGACATGAAAGAAATTATACCAAGGTGAATTTCTGCAAATGTGAAGAATGTGAAAAAGCTGTTAACCAATCTTCAAAGC
TTACTAAACATAAAAGAATTTATACTTGTGAGAAACTCTACAAATGTCAAGAATGTGACAGAACTTTTAACCAATTCTCAAACCTTACTG
AATATAAAAAAGATTATGCTCGAGAGAAACCATACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTCCTCACACCTTACTACACATA
AGATAATTCATACAGGAGAGAAACCCTACAAATGTGAAGAATGTGGCAAAGCCTTTAACCAGTTCTCAAATCTTACTACACATAAAAAAA
TTCATACTGGAGAGCAACCCTACATATGTGAAGAATGTGGCAAGGCTTTTACCCAATCCTCAACCCTTACTACACATAAGAGAATTCATA
CTGGAGAAAAACCCTACAAATGTGAAGAATGTGGAAAAGCTTTTAACCGATCCTCAAAACTTACTGAACATAAAAACATTCATACTGGAG
AGCAACCCTACAAATGTGAGGAATGCGGCAAAGCTTTTAACCGATCCTCAAATCTTACGGAACATAGGAAAATTCATACCGAAGAGAAAC
CCTACAAATGTAAAGAATGTGGCAAAGCTTTTAAACACTCCTCAGCCCTTACTACACATAAGAGAATTCACACTGGAGAGAAACCCTACA
AATGTGAAGAATGTGGCAAAGCTTTTAACCGATCCTCAAAACTTACTGAACATAAGAAACTTCATACTGGAAAGAAACCCTACAAATGTG
AAGAATGTGGCAAAGCTTTTATCCAATCCTCAAAACTTACTGAACATAAGAAAATTCATTCTGGAGAGATACCCTACAAGTGTGAAGAAT
GTGGCAAAGCTTTTAAACACTCCTCATCCCTTACTACACATAAAAGAATTCATACTGGGGAGAAACCCTACAAATGTGAAGAATGTGGCA
AAGCTTTTAGCCGATCCTCAAAACTTACTGAACATAAGATAATTCATACTGGAGAGAAACCCTATAAATGTGAGAGATGTGACAAAGCTT
TTAACCAATCTGCAAACCTTACTAAACATAAAAAAATACATACTGGAGAGAAACTACAGAACTGGAATGTGTGATAATGATTTTGACAAC
ACCTCAAATTTTTCTAAATATAAAGGAAATCATACTGGTGAAAAATTCTAGAAATGTAAAGAATGTGTCAAAGACTTTAAATGGTTTTCA
CACTTCATTGTATGTAAGATAATTCATACTGGAGAAAACTACAAGTGTGAAGAATTTGGCAATACTGTTAATTAAGGCTCAAACCTTATT
GCACAGGAAAGCGTTTATACTTAAGAAAAATTGTACAAATATAAAGAGTGTAAAATAGCCATTAATATCTGTTGACATCTTAATATCAGA
ATGTTGGTACTTAATAAAAGCATTATAAATGCAATTACTGTCTAAAGACTTTAAGAAAATATAAGCCTTTAAAGTGAAGAAGAGTATTCG

>16722_16722_1_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000359788_length(amino acids)=585AA_BP=20
MGYSSSCICKSGLKNNIQGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNE
PPVMCSHFAQEFWPEQNIKDSFEKVTLRRYEKCGNDNFQLKGCKSVDECKLHKGGYNGLNQCLPTMQSKMFQCDKYVKVFNKFSHSDRHK
IKHMENKPFKCKECGRSFCMLSHLTRHERNYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNLTEYKKDYARE
KPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKCEECGKAFNQFSNLTTHKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTGEKPYKCE
ECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAF
NRSSKLTEHKKLHTGKKPYKCEECGKAFIQSSKLTEHKKIHSGEIPYKCEECGKAFKHSSSLTTHKRIHTGEKPYKCEECGKAFSRSSKL

--------------------------------------------------------------
>16722_16722_2_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000596211_length(transcript)=749nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGACTGTTGA
CATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTATATAAAAATGTGATTTTAG
AGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTG
TGAAGAGACATGAGATGGTGAATGAACCCCCAGGCCAAAAGCAATAGCCGATTTGGATACCATCAAGACACCTGAAACCTTATCATGAGC
CAGATGCCAAGGAAGAGACTCTGGGAGGATCCCAAGGACCCCCTGGTTGCAGCCATGTCAAGACTGACACTGAGAAGGACCCCAACTGTC

>16722_16722_2_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000596211_length(amino acids)=96AA_BP=17
MGYSSSCICKSGLKNNIQGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNE

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>16722_16722_3_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000599168_length(transcript)=752nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGACTGTTGA
CATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTATATAAAAATGTGATTTTAG
AGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTG
TGAAGAGACATGAGATGGTGAATGAACCCCCAGGTAAGTGAGAATGAAAGTGAATACAACAGGTGACACTGATGAGAGGTCCAAAGGTCA
AAGAGAAAGCCAGTCCTTAAAATGTGATTTGGGAAGCCGTGTTTTAAAGGAAATAATTTCTGGAAAGCCTGAGTATTTTATGCTCTCACA

>16722_16722_3_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000599168_length(amino acids)=94AA_BP=17
MGYSSSCICKSGLKNNIQGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNE

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>16722_16722_4_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000600313_length(transcript)=711nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGACTGTTGA
CATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTATATAAAAATGTGATTTTAG
AGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTG
TGAAGAGACATGAGATGGTGAATGAACCCCCAGGTCTCCCTCTGATGCCGAGCCGAAGCTGGACTGTACTGCTGCCATCTCTGCTCACTG

>16722_16722_4_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000600313_length(amino acids)=135AA_BP=20
MGYSSSCICKSGLKNNIQGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNE

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>16722_16722_5_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000601010_length(transcript)=861nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGACTGTTGA
CATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTATATAAAAATGTGATTTTAG
AGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTG
TGAAGAGACATGAGATGGTGAATGAACCCCCAGAGTCTCGCCCTGTCGTCCAGCCTGAAGTTCAGTGGTACAATCTCTGCTTACTGCAAC
CTCCACCTCCCAGGTTCAAGTGATTCTCCTGTCTCAGCCTCCTGAGTAGCTGGGACTATAGGCACATGCCACCATGCCTGACTAATTTTT
GTACTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAAGCTGGTCTTGAACTCCTGACCTCGTGATCCATCTTCCTTGGCCTCCCAAAG

>16722_16722_5_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000601010_length(amino acids)=118AA_BP=17
MGYSSSCICKSGLKNNIQGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNE

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>16722_16722_6_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000601935_length(transcript)=1627nt_BP=350nt
AGTCTTTTCTGTCTTCAGAGCATTAGTGTGCACATTAAGTCTTCAGCCTTGTTGAGATAGTGAATATTTATGCCGTATTTGAGAATTAAT
ATTAGCAGAAATGTACAATGTAGATTTCTTTTTAAAATTCTAGGTTACTTTATGGAATTGGGCTCTTAGAGAACAAGAAAAGACTGAAGT
TTTACGGGAAAACAAATCATGTGGTCTTCAGATTCTGAAATAAGGAGAAATGCAGCCATCTGAAATGGTCATGAACCCCAAACAAGTCTT
CCTCTCTGTGCTGATATTTGGAGTAGCTGGGCTACTCCTCTTCATGTATTTGCAAGTCTGGATTGAAGAACAACATACAGGGACTGTTGA
CATTTAGGGATGTGGCCATAGAATTCTCTCTGGAAGAATGGCAATGCCTGGACACTGCACAGCGGAATTTATATAAAAATGTGATTTTAG
AGAACTACAGAAACCTGGTCTTCCTGGGTATTGCTGTCTCTAAGCAAGACCTGATCACCTGTCTGGAGCAAGAAAAAGAGCCTTTGACTG
TGAAGAGACATGAGATGGTGAATGAACCCCCAGGATCTGTGGGACAGACCCAGCAGGTGGTGCCCCATGTAAGAAGCAATGAAATGCATC
ATGATGGAACCCTCAAAAACGAAAGTGAAGTTACTGCACACCCCTTAGGTCCTCTTTGGATTCCAGCATGATGCATCAAACCTTACCACG
GCATGACTAGGGCCCAACCTGCTACCAGAAATAAAGGAAATGACGATGCAGAACCCACAACCCTGGATGATGTGGCTTCCTTGGATGACA
CAGGCCCCAGACATTACCTGGGGAATGCTGAAGAACACAACTCAGGAGGCTGAACAAATCTGCTTCAGACACAGATACCATTCAATCCAT
ATAATTTGTTCTTTGCTATGCTTTTTATTCCACATTGCAACTCTTATAGAATACTGATTCTTCTTATTCTCTCTTTTTGCCTGCAACCCA
CACCTGCTATAAACTATTGGGCCCATCTTCTAGATCTGCCTTTCTTACGGCATTTTACTTGGGAAGGTACCCCCTTCTCAGCCTCTGACA
ACGTGACCAATTGGCTGGGAGGTATTGACTTACCCCCGGTGGGGTCCCTCAGTAATGGCACACATTGGACTCAGGTGCCAAGTAACATTA
CATATCAATCCTTGATTGGAAAAGAATAATATTGATTATACTCATGTTTGTCTTATGTTATTTACTGGTTCTAGGGTGCAAAGCTGGAAC
ACAAACTGTAACCATTGCACCAGTCAAACCTGTCGCTGCTCAGATCTGTATGCTTCAATCAACAAAACCTGATGCAAAAAAACAGAAAAA
GGGGAGATGTGGGAGATTGGTCAGAGTGGTGGAAAAAGGATAGGGAAAGAACGCAAATTTTCTGAAATGTTGGAAGGTCCTGCAGAGCTC
CAGGGGAGAATAGCTGAAGGCAGCTGTTCTATAACCCTGAGGCAGAGAGCAAGCAGTAGGTACAAGGGAGTGTGGAAGAATTTATCTTAA
ACAGGCTTATTTACTTATGTTGATCAGGAACTGACCTTTGATCATTTGCGTGTGTGACATTCCCTGAAAGGGGAACAATAAATGTTAATT

>16722_16722_6_CHST9-ZNF675_CHST9_chr18_24722653_ENST00000581714_ZNF675_chr19_23845960_ENST00000601935_length(amino acids)=134AA_BP=17
MGYSSSCICKSGLKNNIQGLLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEPLTVKRHEMVNE

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Fusion Gene PPI Analysis for CHST9-ZNF675

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CHST9-ZNF675

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CHST9-ZNF675

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source