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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CHSY3-ANKH (FusionGDB2 ID:16732)

Fusion Gene Summary for CHSY3-ANKH

Fusion gene summary

Fusion gene information	Fusion gene name: CHSY3-ANKH
	Fusion gene ID: 16732
		Hgene	Tgene
	Gene symbol	CHSY3	ANKH
	Gene ID	337876	56172
	Gene name	chondroitin sulfate synthase 3	ANKH inorganic pyrophosphate transport regulator
	Synonyms	CHSY2\|CSS3	ANK\|CCAL2\|CMDJ\|CPPDD\|HANK\|MANK\|SLC62A1
	Cytomap	5q23.3	5p15.2
	Type of gene	protein-coding	protein-coding
	Description	chondroitin sulfate synthase 3N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3N-acetylgalactosaminyltransferase 3carbohydrate synthase 2chSy-2chondroitin glucuronyltransferase 3chondroitin synthase-2glucuronosyl-N-acetylgalactos	progressive ankylosis protein homologankylosis, progressive homolog
	Modification date	20200313	20200313
	UniProtAcc	Q70JA7	Q8IWZ3
	Ensembl transtripts involved in fusion gene	ENST00000507545, ENST00000305031,	ENST00000284268, ENST00000503939, ENST00000535119,
Fusion gene scores	* DoF score	9 X 6 X 5=270	13 X 11 X 7=1001
	# samples	10	14
	** MAII score	log2(10/270*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1001*10)=-2.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CHSY3 [Title/Abstract] AND ANKH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CHSY3(129244053)-ANKH(14769300), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CHSY3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ANKH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CG-5721-01A	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-

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Fusion Gene ORF analysis for CHSY3-ANKH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000507545	ENST00000284268	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-
3UTR-intron	ENST00000507545	ENST00000503939	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-
3UTR-intron	ENST00000507545	ENST00000535119	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-
5CDS-intron	ENST00000305031	ENST00000503939	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-
5CDS-intron	ENST00000305031	ENST00000535119	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-
In-frame	ENST00000305031	ENST00000284268	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000305031

CHSY3

chr5

129244053

ENST00000284268

ANKH

chr5

14769300

9220

1444

358

2826

822

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000305031	ENST00000284268	CHSY3	chr5	129244053	+	ANKH	chr5	14769300	-	0.000407698	0.99959236

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Fusion Genomic Features for CHSY3-ANKH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CHSY3-ANKH

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:129244053/chr5:14769300)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHSY3 Q70JA7	ANKH Q8IWZ3
FUNCTION: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1. {ECO:0000269\|PubMed:12907687}.	FUNCTION: May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269\|PubMed:16098192}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHSY3

chr5:129244053

chr5:14769300

ENST00000305031

211_235

362

883.0

Compositional bias

Note=Pro-rich

Hgene

CHSY3

chr5:129244053

chr5:14769300

ENST00000305031

1_7

362

883.0

Topological domain

Cytoplasmic

Hgene

CHSY3

chr5:129244053

chr5:14769300

ENST00000305031

8_28

362

883.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

107_131

493.0

Topological domain

Extracellular

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

153_158

493.0

Topological domain

Cytoplasmic

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

180_189

493.0

Topological domain

Extracellular

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

211_326

493.0

Topological domain

Cytoplasmic

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

348_350

493.0

Topological domain

Extracellular

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

372_403

493.0

Topological domain

Cytoplasmic

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

427_429

493.0

Topological domain

Extracellular

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

453_492

493.0

Topological domain

Cytoplasmic

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

132_152

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

159_179

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

190_210

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

327_347

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

351_371

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

404_426

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

430_452

493.0

Transmembrane

Helical

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

86_106

493.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHSY3

chr5:129244053

chr5:14769300

ENST00000305031

539_544

362

883.0

Compositional bias

Note=Poly-Leu

Hgene

CHSY3

chr5:129244053

chr5:14769300

ENST00000305031

29_882

362

883.0

Topological domain

Lumenal

Tgene

ANKH

chr5:129244053

chr5:14769300

ENST00000284268

1_85

493.0

Topological domain

Cytoplasmic

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Fusion Gene Sequence for CHSY3-ANKH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16732_16732_1_CHSY3-ANKH_CHSY3_chr5_129244053_ENST00000305031_ANKH_chr5_14769300_ENST00000284268_length(transcript)=9220nt_BP=1444nt
GGGTGGCAGCCTAGGAGCGGACGCGTTGCCGCCGCCGCTGCTCCTCCTCCTCCTCCTGCAGCTCCTCCAGCTGCCGCTGCTGCCGCCGCT
GCCGCCACCGCCGCCGCCGGGAGAAGTTTCACTCCCGACCCTTGCTCGGAGCCCCGGCCCAGAGCTGAGCGGGAGCCCGGCAGGCAGCTG
CAGCCCGCGGCAGTCGAGGCGTCCGCGGCGCTTCGACCTCCAGCCGGTGTCGGCGCCTAGGCGGCCGGCTGCGGCCGCGGCTGGGGGCGC
AAAGGCGGAGGAGGGGCGGGTGTGAGCCGGGGAAACCGCGTGCCGCGCCGCGACAGCCCAGCGAGCGTCCGCGCCCGGGACAGCCGCGAT
GGCTGTGCGCTCTCGCCGCCCGTGGATGAGCGTGGCATTAGGGCTGGTGCTGGGCTTCACCGCCGCGTCCTGGCTCATCGCCCCCAGGGT
GGCGGAGCTGAGCGAGAGGAAGAGACGTGGCTCCAGCCTCTGCTCCTACTACGGTCGCTCTGCTGCTGGCCCCCGCGCCGGCGCTCAGCA
GCCGCTCCCCCAGCCCCAGTCCCGACCACGGCAGGAGCAGTCGCCGCCCCCCGCGCGCCAGGATCTCCAGGGGCCACCGCTGCCCGAGGC
AGCACCCGGGATCACCAGTTTTCGAAGCAGCCCCTGGCAGCAGCCACCTCCGCTGCAGCAGCGGCGGCGAGGACGCGAGCCTGAGGGCGC
GACGGGGCTTCCCGGTGCTCCAGCGGCCGAGGGGGAGCCCGAGGAGGAGGACGGGGGCGCGGCTGGGCAGCGGAGAGACGGCCGGCCGGG
GAGTAGCCACAACGGCAGCGGGGACGGGGGCGCTGCCGCCCCGAGCGCCCGACCCCGGGACTTCCTGTACGTGGGGGTGATGACCGCGCA
GAAGTACCTGGGCAGCCGCGCGCTGGCCGCGCAGCGGACCTGGGCGCGTTTCATCCCGGGCCGCGTGGAGTTCTTTTCCAGCCAGCAGCC
CCCCAACGCCGGCCAGCCCCCGCCACCCCTGCCTGTCATCGCGCTACCGGGTGTGGACGACTCCTATCCTCCCCAGAAAAAGTCCTTCAT
GATGATCAAGTACATGCACGACCACTACCTGGACAAGTATGAGTGGTTCATGCGCGCCGACGACGATGTCTACATCAAAGGTGATAAATT
AGAAGAGTTTCTTAGATCGCTAAACAGCAGTAAGCCTCTCTACCTGGGACAGACTGGCCTGGGGAATATTGAAGAGCTTGGAAAGCTGGG
ACTGGAGCCTGGGGAAAACTTCTGTATGGGAGGACCTGGCATGATCTTTAGCCGAGAAGTTCTCAGGAGGATGGTGCCACATATTGGTGA
ATGCCTTAGAGAAATGTACACGACTCATGAGGATGTGGAAGTAGGAAGATGCGTTCGCCGTTTTGGTGGGACTCAGTGTGTCTGGTCTTA
CGAGGCCTTGAACCGGGGCATTGCTGCTGTCAAGGAGGATGCAGTCGAGATGCTGGCCAGCTACGGGCTGGCGTACTCCCTCATGAAGTT
CTTCACGGGTCCCATGAGTGACTTCAAAAATGTGGGCCTGGTGTTTGTGAACAGCAAGAGAGACAGGACCAAAGCCGTCCTGTGTATGGT
GGTGGCAGGGGCCATCGCTGCCGTCTTTCACACACTGATAGCTTATAGTGATTTAGGATACTACATTATCAATAAACTGCACCATGTGGA
CGAGTCGGTGGGGAGCAAGACGAGAAGGGCCTTCCTGTACCTCGCCGCCTTTCCTTTCATGGACGCAATGGCATGGACCCATGCTGGCAT
TCTCTTAAAACACAAATACAGTTTCCTGGTGGGATGTGCCTCAATCTCAGATGTCATAGCTCAGGTTGTTTTTGTAGCCATTTTGCTTCA
CAGTCACCTGGAATGCCGGGAGCCCCTGCTCATCCCGATCCTCTCCTTGTACATGGGCGCACTTGTGCGCTGCACCACCCTGTGCCTGGG
CTACTACAAGAACATTCACGACATCATCCCTGACAGAAGTGGCCCGGAGCTGGGGGGAGATGCAACAATAAGAAAGATGCTGAGCTTCTG
GTGGCCTTTGGCTCTAATTCTGGCCACACAGAGAATCAGTCGGCCTATTGTCAACCTCTTTGTTTCCCGGGACCTTGGTGGCAGTTCTGC
AGCCACAGAGGCAGTGGCGATTTTGACAGCCACATACCCTGTGGGTCACATGCCATACGGCTGGTTGACGGAAATCCGTGCTGTGTATCC
TGCTTTCGACAAGAATAACCCCAGCAACAAACTGGTGAGCACGAGCAACACAGTCACGGCAGCCCACATCAAGAAGTTCACCTTCGTCTG
CATGGCTCTGTCACTCACGCTCTGTTTCGTGATGTTTTGGACACCCAACGTGTCTGAGAAAATCTTGATAGACATCATCGGAGTGGACTT
TGCCTTTGCAGAACTCTGTGTTGTTCCTTTGCGGATCTTCTCCTTCTTCCCAGTTCCAGTCACAGTGAGGGCGCATCTCACCGGGTGGCT
GATGACACTGAAGAAAACCTTCGTCCTTGCCCCCAGCTCTGTGCTGCGGATCATCGTCCTCATCGCCAGCCTCGTGGTCCTACCCTACCT
GGGGGTGCACGGTGCGACCCTGGGCGTGGGCTCCCTCCTGGCGGGCTTTGTGGGAGAATCCACCATGGTCGCCATCGCTGCGTGCTATGT
CTACCGGAAGCAGAAAAAGAAGATGGAGAATGAGTCGGCCACGGAGGGGGAAGACTCTGCCATGACAGACATGCCTCCGACAGAGGAGGT
GACAGACATCGTGGAAATGAGAGAGGAGAATGAATAAGGCACGGGACGCCATGGGCACTGCAGGGACAGTCAGTCAGGATGACACTTCGG
CATCATCTCTTCCCTCTCCCATCGTATTTTGTTCCCTTTTTTTTGTTTTGTTTTGGTAATGAAAGAGGCCTTGATTTAAAGGTTTCGTGT
CAATTCTCTAGCATACTGGGTATGCTCACACTGACGGGGGGACCTAGTGAATGGTCTTTACTGTTGCTATGTAAAAACAAACGAAACAAC
TGACTTCATACCCCTGCCTCACGAAAACCCAAAAGACACAGCTGCCTCACGGTTGACGTTGTGTCCTCCTCCCCTGGACAATCTCCTCTT
GGAACCAAAGGACTGCAGCTGTGCCATCGCGCCTCGGTCACCCTGCACAGCAGGCCACAGACTCTCCTGTCCCCCTTCATCGCTCTTAAG
AATCAACAGGTTAAAACTCGGCTTCCTTTGATTTGCTTCCCAGTCACATGGCCGTACAAAGAGATGGAGCCCCGGTGGCCTCTTAAATTT
CCCTTCCGCCACGGAGTTCGAAACCATCTACTCCACACATGCAGGAGGCGGGTGGCACGCTGCAGCCCGGAGTCCCCGTTCACACTGAGG
AACGGAGACCTGTGACCACAGCAGGCTGACAGATGGACAGAATCTCCCGTAGAAAGGTTTGGTTTGAAATGCCCCGGGGGCAGCAAACTG
ACATGGTTGAATGATAGCATTTCACTCTGCGTTCTCCTAGATCTGAGCAAGCTGTCAGTTCTCACCCCCACCGTGTATATACATGAGCTA
ACTTTTTTAAATTGTCACAAAAGCGCATCTCCAGATTCCAGACCCTGCCGCATGACTTTTCCTGAAGGCTTGCTTTTCCCTCGCCTTTCC
TGAAGGTCGCATTAGAGCGAGTCACATGGAGCATCCTAACTTTGCATTTTAGTTTTTACAGTGAACTGAAGCTTTAAGTCTCATCCAGCA
TTCTAATGCCAGGTTGCTGTAGGGTAACTTTTGAAGTAGATATATTACCTGGTTCTGCTATCCTTAGTCATAACTCTGCGGTACAGGTAA
TTGAGAATGTACTACGGTACTTCCCTCCCACACCATACGATAAAGCAAGACATTTTATAACGATACCAGAGTCACTATGTGGTCCTCCCT
GAAATAACGCATTCGAAATCCATGCAGTGCAGTATATTTTTCTAAGTTTTGGAAAGCAGGTTTTTTCCTTTAAAAAAATTATAGACACGG
TTCACTAAATTGATTTAGTCAGAATTCCTAGACTGAAAGAACCTAAAAAAAAAAATATTTTAAAGATATAAATATATGCTGTATATGTTA
TGTAATTTATTTTAGGCTATAATACATTTCCTATTTTCGCATTTTCAATAAAATGTCTCTAATACAATACGGTGATTGCTTGTGTGCTCA
ACATACCTGCAGTTGAAACGTATTGTATCAATGAACATTGTACCTTATTGGCAGCAGTTTTATAAAGTCCGTCATTTGCATTTGAATGTA
AGGCTCAGTAAATGACAGAACTATTTTTCATTATGGGTAACTGGGGAATAAATGGGTCACTGGAGTAGGAATAGAAGTGCAAGCTGGAAA
GGCAAAAATGAGAAAGAAAAAGGCAGGCCCTTTGTGTCTACCGTTTTCAGTGCTGTGTGATCATATTGTTCCTCACAGCAAAAAAGAATG
CAAGGGCATAATGTTAGCTGTGAACATGCCAGGGTTGCATTCACATTCCTGGGTACCCAGTGCTGATGGGGTGTGCCCACGTGGGGACAT
GTCCTTGGCGTGCTTCCTCAGAGTGGCTTTTCCTCCATTAATACATATATGAGTACTGAAAAATTAAGTTGCATAGCTGCTTTGCAGTGG
TTTCAGAGGCAGATCTGAGAAGATTAAAAAAAAATCTCAATGTATCAGCTTTTTTTAAAGGACATTACTAGAAAATTAAACAGTATTTTT
TAACATGTGTGACTTTCATGCTTCTGGGGTTGGAGCTTAAAGATCCAAACTGAGAAAGCAGGCCGGGCATGGTGGCTCATGCCTGTAATC
CCAACACTTTGGGAGGCCAAGGAGGGTGGATCACTTAAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGCAAAACCCTGTCTCTACT
AAAAACATAAAAATTAGCTGGGGGTGGTAGCACATACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTTGCTTGATCCTGG
GAGGCAGAGGTTGTAGTGAGCCGAGATCGCGCCATCGCACTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAATC
CTTTCCCTCTAAATCCAGGAAGGATCAGCAAGGGCCTCCTCATTATGAGATGAGGAAATACAACTCCAGAGATTCCTTCAGTGATCAAGA
TCAGTGGGCCATAATATTTGGTTAGAGTTTCTGAGAACACAGGAAGCAATGCCACACTCAGGCCACCACAATGGAGCTGATTTGGCAGGA
CTTGTTCAAACCTTTCACCTTAAAGCACGTGATCCTTCTTCGTACATTTTCTTCACTTGGGCTGCTTAAGTCACAGCCTAACAACTTTGA
GGCAAAACTGAGAACTGGCATATTCTCCTGCGTTTCTTCTAATCGAGTCCCATCATCCAGCTAGACATGAGAGATCAAACCAGGGAGGGT
GACCTTTCTCCTTCCCACTTTTCAGAGTCATTGGGGCAACTTTTTGACTTTTGTGACCAAAGAAACATTCCCCCAAAACATTTATTTTTC
ATTGTAGGGCATTCAGCTGACAGCTGCATTTTAGAAAGTTACCATGCCTGTGAGATTCTCATGTCAAAGACCAGGGAAAGACCAGGTGTG
ACTTTCTCCAAAACTGAGTGATTGCTTGTGGATGAATACAATCTAAAAATACAAGGCCATGAAGTAGTTTTTCATTTAGATGCTGAGAAA
TAATAGGTTTGGGCAGCTCAAAGCATAGGAAATAGTAAGGGTTTTCTAGAGCTCCTCCTTTGGTGGCCTGTTTGAGTAGCACAAGGGACG
TCATCCTAAATGTGCAGTTGCCATTTGTTCTGTAGTGACTTACAGGGATCTCAGTGGCAAAGGGCGTCAGTGAGACAACAACTGAGCAAA
AAGAACTAGACGAGGCTTGCGCTTGGAAAGTCACGGTAGGATTGGACCTGCCGGCCACATGGCTCAGGGAGTATTGACGGATTTGCACAT
TGGCAGGAAACTCTCCCGTTTGGGATTCTTTAAATGGGGCACAGAAGGCCACTTGTTTGCATTTCTGGGTAAAAAACAGTCATCCCCCAT
GACTGCCTGCATCGGGTTTGTCTTGTGCCAAAGTTACTCTTCCTTTGTTTTTACTTTGCCTTGATTTTTAGCATTAGCTGGTAGTTTGGC
TTGGAAATGTCCTGGATAGCCGATTCCCTAAGAAACTGAAACATTTAATATTGGCTTAGGATGTATCAGATGGGGCCAAATAAAGCTTCT
TTACAATAGTAAAAGCACTTTATACTTCACTCTCTGAGTCTTCCCAATAAATAACCTTGGGAGGTGCAGGGGGTGGGGGGCCCAGGATGG
GGAGGCCTGGGAGCTCCCAGGGTAGTGACAGAGTTGGGCTGAGTTCTCCAGACGCCAGGATGCGTCGCAGCGGGGCCAGCTCAGGAGTGC
TCACTCCCAGCCCTCTGGATCTCTCTCCTGGTTGGAATAATCATTACATATCGTAACTCTCAAAATTTATTCACTTATATTTTCAGAATA
AGAAGTGTGAAATGTTAACAGCTCTCTGCTCTCTTACTTGTTCCCCATTTGGGGATCTTCTGGAGGGAAGGGGCAGGGGGAGAGTAACTT
TTCTATATCCTTGGTTTCTAGGAACACATCGATTTGAAGACTCAGTAGCTGACTGGTTTTTTTTTTTCCCCCTTCAAACTGAAGTGCGAG
TGTGCGTGTGTTCCACAAAATAGCAAGTATTTATAGTGTTGTAATTACATTTCCTTGAGAAATATTTTCTTGTATTTAAAAATCTTTCTA
CTTCAGTAACTCCCAGCAGAACAGTGCCCAGGACAGCATGTGCCGGTTAGTACCAGCTTTGCAGGTGAGCTGACTTCTAAACTTAGGACG
ACGTCTTCATCAATCAAACTAGTGCACAGTCCAGAAAAAGGGGTCCTTTATCTTCTAAGTTCTGCTCCTCACCTTTCTTTGGAACCAAAA
TTGCAGTGGAGTGTGAGGAAGAGCTTTGAAAGACGTGGAGTGTTGAGATGTCTGCATTGCACATTCAGCCGGTTCAAAGCCAGCAGCTCC
TGCCTGCATTCTGTAGACATCGCCCTCACACACAGTCCTCTGATGGCTCTCATATAAAGCACTCAAACCGTAGGAAAGCATGTTTTTGAG
CAACGTGTCTGGGATACTCCTCTGTGTGGTTATTTTGAATCTCTATTTCTGTCATTGAAGCAGCAAAAAACATCATGTGACTCATCAACT
GATCTAATCACACTTAAAACAGGATGTAGAGAAAAATCTGATGAGAAACGTAAAAGGGCCTGTTGCCTGCCCTTTTAAAGGCAAAATGTC
TAAAATCATGCAAATGTTCAAAATGAGAGAAATTGCATTGTGGAATCAAAATAACCCAAACTCCACTCAGAAAAGTCACAAATATATAGT
ATACTATCTGATCTCAAAAGGGAAAAACGAGATGATAAGACCTTAAGTTTAGACTTTATTTTCTTCTCAAGAGTGGACATTAAATCTATT
AACTTGCAACTTTCTGCTGGGAAGAGCATCAAAGGTGGGCCTCCTAAATCATTTTTGAAAAACCTCTGTCAAGTCCAAGTGGTTCCAGGA
GAATTATAGCCAGTATCTTTTAAAATATTTCATTTTAGTGATAATGTTTTTCTCTGCTTCATTTGCAATCAACCAGGATCTCTAAAAGAC
TGCATAAGATATATGCACTTTTATAGGTGGCTGTCAGCTACACATAGATTCAGCAAATTTTTTTTATATAGTACCTGTTTTTAAGTTAGG
CTACATAACTTAAAGTGCACTTTACTAACAAGACTTGACATTAGCGTCTACAATATGTATATGTAAACAAAAGCACACAAGAACTAGGCA
CCCTTTCTCTCTCCAAGAGTTTAAGTGGTTTCCTTAGGTTAAAGAAGGGGACAGACCAGCTAAAAATGGTTGTACCACTCACTGTACAAC
CTCATGGAAATTCTCACTATAAGATTTAGAGGCAATGTTCCCTAGCTATAAGCCAGGGCAAGAAATGGCGCCTCTGGAGTTGGGGAACAT
TAGGGGAACATTACAACCGGGTAGATGCTGGTTCCCTGAAGTGTGGGGCCATGAACATGCAGGGACCCACGGTTTGAATGAAACAGCTAC
TGAAAGCTAAGTTCAAACCACCCTTGCGTAACAAAGGAGTACAGGGTACACATCAACACCAATCACCCAGCACCCCACAGCGATGGTCAT
GTCACCGTGCAGCAGGTCCCTTACCCCAGGGCTGCCACATCCACAAGCCTTGCAGTGGCAAATACGCTGCTCCTTGGATTTAATGAGATA
TTTTGGTTGCTTAATGATGTACTGATCAGGGAACTGTCTAAAGCTAGTAGGGCCAAGGAGTTAATCAAAGGGCTTCGGGAAAGTGGACAA
GAGCCACACACGTGATTCTGTTCCATGCCGACACTCATTCATTTAAGAAGTGTATTCAAGCTGGAGGCTTCCATATCACTCACGCTTCTT
GGCCTCACCTTGCTCATCTGTCCAATGGGAGGCTTGAGCCATTATTGCTAAGGCCCCTTCCTGATCTAACATTCTGTTTATGATCTAGGA
TTTAGAACGTCGTATGAGATCCTACAATGGAAGAATAAAATCACCTCATTCTTCATTTCAGATCTGAACATTAGCAGTGATCTAGATTTT
TTTTTTTTTAAACAAAATTAAGTGTGCTTAGAGTCATTCCTCTACATGGGCTGTGGCTGTCAGCCCATAGGTTTGTCAGTTTCACATCAA
AACTGTGGGTATAAACTGTTGAAACCAATCACATTAAAATATTTAGCTGGGCACAGTGGTGTGCATCTGTAGTCCCAGCTACTTGGGAGG
CTGAGGCAGGAGGATCGCTTAAGCACAGGAGTTGGAATCCAGCCTGAGCAACAGAGCAAAACCCCGTCTCTAAAATACAAATAAAATATT
TGTGTAGTTTTTGATTAAAATTGACTACAGCGGTCAGTATAAAATACATGTCGCTTTTAAGGAAGTGCTCTTTATGTATCTAACAGATGG
AAGTTTTTGCATTGGTAAGAGCATTTATATATGCTTTGTTTCAGGGTTTATGGATTTGTATTCATATATTGTCAAATAGGTTTCATACTC

>16732_16732_1_CHSY3-ANKH_CHSY3_chr5_129244053_ENST00000305031_ANKH_chr5_14769300_ENST00000284268_length(amino acids)=822AA_BP=362
MAVRSRRPWMSVALGLVLGFTAASWLIAPRVAELSERKRRGSSLCSYYGRSAAGPRAGAQQPLPQPQSRPRQEQSPPPARQDLQGPPLPE
AAPGITSFRSSPWQQPPPLQQRRRGREPEGATGLPGAPAAEGEPEEEDGGAAGQRRDGRPGSSHNGSGDGGAAAPSARPRDFLYVGVMTA
QKYLGSRALAAQRTWARFIPGRVEFFSSQQPPNAGQPPPPLPVIALPGVDDSYPPQKKSFMMIKYMHDHYLDKYEWFMRADDDVYIKGDK
LEEFLRSLNSSKPLYLGQTGLGNIEELGKLGLEPGENFCMGGPGMIFSREVLRRMVPHIGECLREMYTTHEDVEVGRCVRRFGGTQCVWS
YEALNRGIAAVKEDAVEMLASYGLAYSLMKFFTGPMSDFKNVGLVFVNSKRDRTKAVLCMVVAGAIAAVFHTLIAYSDLGYYIINKLHHV
DESVGSKTRRAFLYLAAFPFMDAMAWTHAGILLKHKYSFLVGCASISDVIAQVVFVAILLHSHLECREPLLIPILSLYMGALVRCTTLCL
GYYKNIHDIIPDRSGPELGGDATIRKMLSFWWPLALILATQRISRPIVNLFVSRDLGGSSAATEAVAILTATYPVGHMPYGWLTEIRAVY
PAFDKNNPSNKLVSTSNTVTAAHIKKFTFVCMALSLTLCFVMFWTPNVSEKILIDIIGVDFAFAELCVVPLRIFSFFPVPVTVRAHLTGW
LMTLKKTFVLAPSSVLRIIVLIASLVVLPYLGVHGATLGVGSLLAGFVGESTMVAIAACYVYRKQKKKMENESATEGEDSAMTDMPPTEE

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Fusion Gene PPI Analysis for CHSY3-ANKH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CHSY3-ANKH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CHSY3-ANKH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source