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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CIAPIN1-COQ9 (FusionGDB2 ID:16778)

Fusion Gene Summary for CIAPIN1-COQ9

check button Fusion gene summary
Fusion gene informationFusion gene name: CIAPIN1-COQ9
Fusion gene ID: 16778
HgeneTgene
Gene symbol

CIAPIN1

COQ9

Gene ID

57019

57017

Gene namecytokine induced apoptosis inhibitor 1coenzyme Q9
SynonymsAnamorsin|CIAE2|DRE2|PRO0915C16orf49|COQ10D5
Cytomap

16q21

16q21

Type of geneprotein-codingprotein-coding
Descriptionanamorsinfe-S cluster assembly protein DRE2 homologpredicted protein of HQ0915ubiquinone biosynthesis protein COQ9, mitochondrialcoenzyme Q9 homolog
Modification date2020032720200313
UniProtAcc

Q6FI81

O75208

Ensembl transtripts involved in fusion geneENST00000394391, ENST00000565961, 
ENST00000567518, ENST00000568940, 
ENST00000569370, ENST00000569979, 
ENST00000569246, 		ENST00000567384, 
ENST00000262507, ENST00000567072, 
ENST00000567933, 
Fusion gene scores* DoF score5 X 4 X 4=803 X 3 X 2=18
# samples 53
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CIAPIN1 [Title/Abstract] AND COQ9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCIAPIN1(57474684)-COQ9(57484952), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CIAPIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across COQ9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A574-01ACIAPIN1chr16

57474684

-COQ9chr16

57484952

+


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Fusion Gene ORF analysis for CIAPIN1-COQ9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000394391ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5CDS-3UTRENST00000565961ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5CDS-3UTRENST00000567518ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5CDS-3UTRENST00000568940ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5CDS-3UTRENST00000569370ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5CDS-3UTRENST00000569979ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5UTR-3CDSENST00000569246ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5UTR-3CDSENST00000569246ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5UTR-3CDSENST00000569246ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
5UTR-3UTRENST00000569246ENST00000567384CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000394391ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000394391ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000394391ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000565961ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000565961ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000565961ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000567518ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000567518ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000567518ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000568940ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000568940ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000568940ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000569370ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000569370ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000569370ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000569979ENST00000262507CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000569979ENST00000567072CIAPIN1chr16

57474684

-COQ9chr16

57484952

+
Frame-shiftENST00000569979ENST00000567933CIAPIN1chr16

57474684

-COQ9chr16

57484952

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CIAPIN1-COQ9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CIAPIN1chr1657474683-COQ9chr1657484951+5.03E-060.999995
CIAPIN1chr1657474683-COQ9chr1657484951+5.03E-060.999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CIAPIN1-COQ9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57474684/:57484952)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CIAPIN1

Q6FI81

COQ9

O75208

FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 (PubMed:23596212). NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:P36152, ECO:0000250|UniProtKB:Q8WTY4, ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:23596212}.FUNCTION: Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7. {ECO:0000269|PubMed:25339443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CIAPIN1-COQ9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CIAPIN1-COQ9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CIAPIN1-COQ9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CIAPIN1-COQ9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource