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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CIRBP-CNN2 (FusionGDB2 ID:16829)

Fusion Gene Summary for CIRBP-CNN2

check button Fusion gene summary
Fusion gene informationFusion gene name: CIRBP-CNN2
Fusion gene ID: 16829
HgeneTgene
Gene symbol

CIRBP

CNN2

Gene ID

1153

1265

Gene namecold inducible RNA binding proteincalponin 2
SynonymsCIRP-
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptioncold-inducible RNA-binding proteinA18 hnRNPglycine-rich RNA binding proteintesticular tissue protein Li 39calponin-2calponin H2, smooth muscleneutral calponin
Modification date2020032720200313
UniProtAcc

Q14011

Q99439

Ensembl transtripts involved in fusion geneENST00000320936, ENST00000413636, 
ENST00000444172, ENST00000586472, 
ENST00000587323, ENST00000587896, 
ENST00000588230, ENST00000589235, 
ENST00000589686, ENST00000589710, 
ENST00000585630, ENST00000586773, 
ENST00000588030, ENST00000588090, 
ENST00000589660, ENST00000590188, 
ENST00000591935, 		ENST00000263097, 
ENST00000348419, ENST00000562958, 
ENST00000565096, ENST00000606983, 
Fusion gene scores* DoF score12 X 7 X 6=50412 X 12 X 8=1152
# samples 1314
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1152*10)=-3.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CIRBP [Title/Abstract] AND CNN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCIRBP(1269409)-CNN2(1031070), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCIRBP

GO:0009411

response to UV

11574538

HgeneCIRBP

GO:0045727

positive regulation of translation

11574538

HgeneCIRBP

GO:0048255

mRNA stabilization

11574538

TgeneCNN2

GO:0032970

regulation of actin filament-based process

16236705

TgeneCNN2

GO:0071260

cellular response to mechanical stimulus

16236705


check buttonFusion gene breakpoints across CIRBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CNN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-4Z-AA87-01ACIRBPchr19

1269409

-CNN2chr19

1031070

+


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Fusion Gene ORF analysis for CIRBP-CNN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000320936ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000413636ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000444172ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000586472ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000587323ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000587896ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000588230ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000589235ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000589686ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3CDSENST00000589710ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000320936ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000320936ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000320936ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000320936ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000413636ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000413636ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000413636ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000413636ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000444172ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000444172ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000444172ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000444172ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000586472ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000586472ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000586472ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000586472ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587323ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587323ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587323ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587323ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587896ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587896ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587896ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000587896ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000588230ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000588230ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000588230ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000588230ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589235ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589235ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589235ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589235ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589686ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589686ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589686ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589686ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589710ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589710ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589710ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
5UTR-3UTRENST00000589710ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000585630ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000586773ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000588030ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000588090ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000589660ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000590188ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3CDSENST00000591935ENST00000263097CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000585630ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000585630ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000585630ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000585630ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000586773ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000586773ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000586773ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000586773ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588030ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588030ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588030ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588030ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588090ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588090ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588090ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000588090ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000589660ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000589660ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000589660ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000589660ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000590188ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000590188ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000590188ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000590188ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000591935ENST00000348419CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000591935ENST00000562958CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000591935ENST00000565096CIRBPchr19

1269409

-CNN2chr19

1031070

+
intron-3UTRENST00000591935ENST00000606983CIRBPchr19

1269409

-CNN2chr19

1031070

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CIRBP-CNN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CIRBP-CNN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1269409/:1031070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CIRBP

Q14011

CNN2

Q99439

FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}.FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CIRBP-CNN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CIRBP-CNN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CIRBP-CNN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CIRBP-CNN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource