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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CIRBP-WNK2 (FusionGDB2 ID:16838)

Fusion Gene Summary for CIRBP-WNK2

Fusion gene summary

Fusion gene information	Fusion gene name: CIRBP-WNK2
	Fusion gene ID: 16838
		Hgene	Tgene
	Gene symbol	CIRBP	WNK2
	Gene ID	1153	65268
	Gene name	cold inducible RNA binding protein	WNK lysine deficient protein kinase 2
	Synonyms	CIRP	NY-CO-43\|P/OKcl.13\|PRKWNK2\|SDCCAG43
	Cytomap	19p13.3	9q22.31
	Type of gene	protein-coding	protein-coding
	Description	cold-inducible RNA-binding proteinA18 hnRNPglycine-rich RNA binding proteintesticular tissue protein Li 39	serine/threonine-protein kinase WNK2antigen NY-CO-43mitogen-activated protein kinase kinase kinaseprotein kinase lysine-deficient 2protein kinase with no lysine 2serologically defined colon cancer antigen 43
	Modification date	20200327	20200313
	UniProtAcc	Q14011	.
	Ensembl transtripts involved in fusion gene	ENST00000320936, ENST00000413636, ENST00000444172, ENST00000585630, ENST00000586472, ENST00000586773, ENST00000587323, ENST00000587896, ENST00000588030, ENST00000588090, ENST00000588230, ENST00000589235, ENST00000589660, ENST00000589686, ENST00000589710, ENST00000591935, ENST00000590188,	ENST00000349097, ENST00000356055, ENST00000395475, ENST00000395477, ENST00000471076, ENST00000297954, ENST00000427277,
Fusion gene scores	* DoF score	12 X 7 X 6=504	10 X 9 X 7=630
	# samples	13	12
	** MAII score	log2(13/504*10)=-1.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CIRBP [Title/Abstract] AND WNK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CIRBP(1272050)-WNK2(96079801), # samples:1
Anticipated loss of major functional domain due to fusion event.	CIRBP-WNK2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CIRBP-WNK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CIRBP-WNK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. CIRBP-WNK2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CIRBP	GO:0009411	response to UV	11574538
Hgene	CIRBP	GO:0045727	positive regulation of translation	11574538
Hgene	CIRBP	GO:0048255	mRNA stabilization	11574538
Tgene	WNK2	GO:0006468	protein phosphorylation	21733846
Tgene	WNK2	GO:0046777	protein autophosphorylation	17667937

Fusion gene breakpoints across CIRBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WNK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-A4QL	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+

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Fusion Gene ORF analysis for CIRBP-WNK2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000320936	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000320936	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000320936	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000320936	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000320936	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000413636	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000413636	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000413636	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000413636	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000413636	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000444172	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000444172	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000444172	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000444172	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000444172	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000585630	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000585630	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000585630	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000585630	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000585630	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586472	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586472	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586472	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586472	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586472	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586773	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586773	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586773	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586773	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000586773	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587323	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587323	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587323	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587323	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587323	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587896	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587896	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587896	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587896	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000587896	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588030	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588030	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588030	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588030	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588030	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588090	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588090	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588090	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588090	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588090	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588230	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588230	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588230	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588230	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000588230	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589235	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589235	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589235	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589235	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589235	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589660	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589660	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589660	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589660	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589660	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589686	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589686	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589686	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589686	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589686	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589710	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589710	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589710	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589710	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000589710	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000591935	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000591935	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000591935	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000591935	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
5CDS-3UTR	ENST00000591935	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000320936	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000320936	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000444172	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000444172	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000585630	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000585630	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000586472	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000586472	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000586773	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000586773	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000587323	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000587323	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000587896	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000587896	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000588030	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000588030	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000588090	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000588090	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000588230	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000588230	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589235	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589235	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589660	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589660	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589686	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589686	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589710	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000589710	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000591935	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
Frame-shift	ENST00000591935	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
In-frame	ENST00000413636	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
In-frame	ENST00000413636	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3CDS	ENST00000590188	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3CDS	ENST00000590188	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3UTR	ENST00000590188	ENST00000349097	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3UTR	ENST00000590188	ENST00000356055	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3UTR	ENST00000590188	ENST00000395475	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3UTR	ENST00000590188	ENST00000395477	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+
intron-3UTR	ENST00000590188	ENST00000471076	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000413636

CIRBP

chr19

1272050

ENST00000427277

WNK2

chr9

96079801

1631

1472

350

805

151

ENST00000413636

CIRBP

chr19

1272050

ENST00000297954

WNK2

chr9

96079801

1983

1472

350

805

151

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000413636	ENST00000427277	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+	0.70975405	0.29024592
ENST00000413636	ENST00000297954	CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+	0.8087697	0.19123027

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Fusion Genomic Features for CIRBP-WNK2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+	0.013455845	0.9865442
CIRBP	chr19	1272050	+	WNK2	chr9	96079801	+	0.013455845	0.9865442

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CIRBP-WNK2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1272050/chr9:96079801)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CIRBP Q14011	.
FUNCTION: Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269\|PubMed:11574538, ECO:0000269\|PubMed:16513844}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000320936

92_158

167

173.0

Compositional bias

Note=Gly-rich

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000585630

92_158

167

173.0

Compositional bias

Note=Gly-rich

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000586472

92_158

167

173.0

Compositional bias

Note=Gly-rich

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000588030

92_158

167

173.0

Compositional bias

Note=Gly-rich

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000588090

92_158

167

173.0

Compositional bias

Note=Gly-rich

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000589660

92_158

167

173.0

Compositional bias

Note=Gly-rich

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000320936

6_84

167

173.0

Domain

RRM

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000585630

6_84

167

173.0

Domain

RRM

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000586472

6_84

167

173.0

Domain

RRM

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000588030

6_84

167

173.0

Domain

RRM

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000588090

6_84

167

173.0

Domain

RRM

Hgene

CIRBP

chr19:1272050

chr9:96079801

ENST00000589660

6_84

167

173.0

Domain

RRM

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WNK2

chr19:1272050

chr9:96079801

ENST00000297954

195_453

2209

2298.0

Domain

Protein kinase

Tgene

WNK2

chr19:1272050

chr9:96079801

ENST00000297954

275_278

2209

2298.0

Nucleotide binding

ATP

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Fusion Gene Sequence for CIRBP-WNK2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16838_16838_1_CIRBP-WNK2_CIRBP_chr19_1272050_ENST00000413636_WNK2_chr9_96079801_ENST00000297954_length(transcript)=1983nt_BP=1472nt
CTCACTCGCGCGTTAGGAGGCTCGGGTCGTTGTGGTGCGCTGTCTTCCCGCTTGCGTCAGGGACCTGCCCGACTCAGTGGCCGCCATGGC
ATCAGATGAAGGCAAACTTTTTGTTGGAGGGCTGAGTTTTGACACCAATGAGCAGTCGCTGGAGCAGGTCTTCTCAAAGTACGGACAGAT
CTCTGAAGTGGTGGTTGTGAAAGACAGGGAGACCCAGAGATCTCGGGGATTTGGGTTTGTCACCTTTGAGAACATTGACGACGCTAAGGA
TGCCATGATGGCCATGAATGGGAAGTCTGTAGATGGACGGCAGATCCGAGTAGACCAGGCAGGAGGAGGGGACCGAGGCTATGGGGGGAA
CCGGTTCGAGTCCAGGAGTGGGGGCTACGGAGGCTCCAGAGACTACTATAGCAGGTAAGTCACACTCCGAGGGCGCCACGCTGCTGTGGC
CTGCGGTGGGAGCTCGGTTCACCTTGGTGCCCTCTCCAAGCACTTTAGGCTGGACACTCAGACCTTGTCACTGTGCTTGCCCAGAAGAGG
CGCATCTGTCCTCTCAGAGCCATTTCTATCGCAGGACGCAAAAGCCAAATGAGACTGACCAAAAAGGCAAGGGAGAGCGAGGGCCCGCTG
GGCAGTCAGCTAGGTGCATGTGTGGCCGCAGGCCAGCCTCCCTCGGCTGTGGGGGGTGGTTGCTCCCCGGCCGCAGGCCGCGCCCTGGTC
TGGCCTCTGGGGTGAAGCTGCCTCTTGTTGCTTCGGTGCCTTTACACTGTGCCTGCTTCTTGTCCTCAGCTACACACAACGAGTAAAAAC
CCTTCCTGCTCAAGATCGTCCTTCCAATGGCTGTGTGTTTAAAGATTGTGGGAGCTTCGCTGAACGTTAATGTGTAGTAAATGCACCTCC
TTGTATTCCCACTTTCGTAGTCATTTCGGTTCTGATCTTGTCAAACCCAGCCTGACCGCTTCTGACGCCGGGATGGCCTCGTTACTAGAC
TTTTCTTTTTAAGGAAGTGCTGTTTTTTTTTGAGGGTTTTCAAAACATTTTGAAAAGCATTTACTTTTTTGACCACGAGCCATGAGTTTT
CAAAAAAATCGGGGGTTGTGTGGGTTTTTGGTTTTTGTTTTAGTTTTTGGTTGCGTTGCCTTTTTTTTTTTAGTGGGGTTGGCCCCATGA
AGTGGGTGCCCCACTCACTTCTCTGAGATCGAACGGACTGTGAATCCGCTCTTTGTCGGAAGCTGAGCAAGCTGTGGCTTTTTTCCAACT
CCGTGTGACGTTTCTGAGTGTAGTGTGGTAGGACCCCGGCGGGTGTGGCAGCAACTGCCCTGGAGCCCCAGCCCCTGCGTCCATCTGTGC
TGTGCGCCCCACAGTAGACGTGCAGACGTCCCTGAGAGGTTCTTGAAGATGTTTATTTATATTGTCCTTTTTTACTGGAAGACGTACGCA
TACTCCATCGATGTTGTATTTGCAGTGGCTGAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTC
TGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGATGGCGCCCTCGGAACCGCCCGGAGAAACCAGGTGT
GGTTTGGCCTCCGAGTCCCCCCCACCGCCTGCTGTGGGCACAGCACTCAGCCGCGAGGGGGACAGCGGGTGGGCAGCAAGACTGCTTCCT
TTGCGGCTTCAGACCCTGTTCGCTCCTAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTTCCTATACTTGAGTTGATGGTTAGAA
CCTTGTCGTCACCCTGCAGAAGTACAGTGCCTTGAATGCCAGCTTTTCCGTTCCCTGATGAAAAGATATGTTAAAAAAAATTATCGGAAA
AGGTTTCATTTGCAATTGGCTTGTGCATTGATAATCTTTATTTACTGTTTTAAGTTGCAGAGATGTGAATGGTTTACAAATCTGAAGCTG

>16838_16838_1_CIRBP-WNK2_CIRBP_chr19_1272050_ENST00000413636_WNK2_chr9_96079801_ENST00000297954_length(amino acids)=151AA_BP=
MGGTGSSPGVGATEAPETTIAGKSHSEGATLLWPAVGARFTLVPSPSTLGWTLRPCHCACPEEAHLSSQSHFYRRTQKPNETDQKGKGER

--------------------------------------------------------------
>16838_16838_2_CIRBP-WNK2_CIRBP_chr19_1272050_ENST00000413636_WNK2_chr9_96079801_ENST00000427277_length(transcript)=1631nt_BP=1472nt
CTCACTCGCGCGTTAGGAGGCTCGGGTCGTTGTGGTGCGCTGTCTTCCCGCTTGCGTCAGGGACCTGCCCGACTCAGTGGCCGCCATGGC
ATCAGATGAAGGCAAACTTTTTGTTGGAGGGCTGAGTTTTGACACCAATGAGCAGTCGCTGGAGCAGGTCTTCTCAAAGTACGGACAGAT
CTCTGAAGTGGTGGTTGTGAAAGACAGGGAGACCCAGAGATCTCGGGGATTTGGGTTTGTCACCTTTGAGAACATTGACGACGCTAAGGA
TGCCATGATGGCCATGAATGGGAAGTCTGTAGATGGACGGCAGATCCGAGTAGACCAGGCAGGAGGAGGGGACCGAGGCTATGGGGGGAA
CCGGTTCGAGTCCAGGAGTGGGGGCTACGGAGGCTCCAGAGACTACTATAGCAGGTAAGTCACACTCCGAGGGCGCCACGCTGCTGTGGC
CTGCGGTGGGAGCTCGGTTCACCTTGGTGCCCTCTCCAAGCACTTTAGGCTGGACACTCAGACCTTGTCACTGTGCTTGCCCAGAAGAGG
CGCATCTGTCCTCTCAGAGCCATTTCTATCGCAGGACGCAAAAGCCAAATGAGACTGACCAAAAAGGCAAGGGAGAGCGAGGGCCCGCTG
GGCAGTCAGCTAGGTGCATGTGTGGCCGCAGGCCAGCCTCCCTCGGCTGTGGGGGGTGGTTGCTCCCCGGCCGCAGGCCGCGCCCTGGTC
TGGCCTCTGGGGTGAAGCTGCCTCTTGTTGCTTCGGTGCCTTTACACTGTGCCTGCTTCTTGTCCTCAGCTACACACAACGAGTAAAAAC
CCTTCCTGCTCAAGATCGTCCTTCCAATGGCTGTGTGTTTAAAGATTGTGGGAGCTTCGCTGAACGTTAATGTGTAGTAAATGCACCTCC
TTGTATTCCCACTTTCGTAGTCATTTCGGTTCTGATCTTGTCAAACCCAGCCTGACCGCTTCTGACGCCGGGATGGCCTCGTTACTAGAC
TTTTCTTTTTAAGGAAGTGCTGTTTTTTTTTGAGGGTTTTCAAAACATTTTGAAAAGCATTTACTTTTTTGACCACGAGCCATGAGTTTT
CAAAAAAATCGGGGGTTGTGTGGGTTTTTGGTTTTTGTTTTAGTTTTTGGTTGCGTTGCCTTTTTTTTTTTAGTGGGGTTGGCCCCATGA
AGTGGGTGCCCCACTCACTTCTCTGAGATCGAACGGACTGTGAATCCGCTCTTTGTCGGAAGCTGAGCAAGCTGTGGCTTTTTTCCAACT
CCGTGTGACGTTTCTGAGTGTAGTGTGGTAGGACCCCGGCGGGTGTGGCAGCAACTGCCCTGGAGCCCCAGCCCCTGCGTCCATCTGTGC
TGTGCGCCCCACAGTAGACGTGCAGACGTCCCTGAGAGGTTCTTGAAGATGTTTATTTATATTGTCCTTTTTTACTGGAAGACGTACGCA
TACTCCATCGATGTTGTATTTGCAGTGGCTGAATGACCGCACCTCGAGCAGGAGTGGGGATGCCACGTCTGCCCCCAGCGCCCGGCCCTC
TGTCCACCACGGTCATTCCCGGAGCCGCCCCGACCCTGTCCGTGCCCACACCAGGTTCCTGTGGTCCACGCGCCGTCTCCACACCCACTT

>16838_16838_2_CIRBP-WNK2_CIRBP_chr19_1272050_ENST00000413636_WNK2_chr9_96079801_ENST00000427277_length(amino acids)=151AA_BP=
MGGTGSSPGVGATEAPETTIAGKSHSEGATLLWPAVGARFTLVPSPSTLGWTLRPCHCACPEEAHLSSQSHFYRRTQKPNETDQKGKGER

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CIRBP-WNK2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CIRBP-WNK2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CIRBP-WNK2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source