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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CIZ1-DBH (FusionGDB2 ID:16877)

Fusion Gene Summary for CIZ1-DBH

Fusion gene summary

Fusion gene information	Fusion gene name: CIZ1-DBH
	Fusion gene ID: 16877
		Hgene	Tgene
	Gene symbol	CIZ1	DBH
	Gene ID	25792	1621
	Gene name	CDKN1A interacting zinc finger protein 1	dopamine beta-hydroxylase
	Synonyms	LSFR1\|NP94\|ZNF356	DBM\|ORTHYP1
	Cytomap	9q34.11	9q34.2
	Type of gene	protein-coding	protein-coding
	Description	cip1-interacting zinc finger proteinnuclear protein NP94zinc finger protein 356	dopamine beta-hydroxylasedopamine beta-hydroxylase (dopamine beta-monooxygenase)
	Modification date	20200313	20200313
	UniProtAcc	Q9ULV3	P09172
	Ensembl transtripts involved in fusion gene	ENST00000476727, ENST00000325721, ENST00000357558, ENST00000372938, ENST00000372954, ENST00000538431, ENST00000541172, ENST00000277465, ENST00000372948, ENST00000393608,	ENST00000393056,
Fusion gene scores	* DoF score	8 X 7 X 2=112	3 X 3 X 3=27
	# samples	7	3
	** MAII score	log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: CIZ1 [Title/Abstract] AND DBH [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CIZ1(130947825)-DBH(136521658), # samples:1
Anticipated loss of major functional domain due to fusion event.	CIZ1-DBH seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CIZ1-DBH seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. CIZ1-DBH seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CIZ1-DBH seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DBH	GO:0042420	dopamine catabolic process	3443096\|7961964

Fusion gene breakpoints across CIZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DBH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-DX-A23Z-01A	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-

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Fusion Gene ORF analysis for CIZ1-DBH

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000476727	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
Frame-shift	ENST00000325721	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
Frame-shift	ENST00000357558	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
Frame-shift	ENST00000372938	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
Frame-shift	ENST00000372954	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
Frame-shift	ENST00000538431	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
Frame-shift	ENST00000541172	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
In-frame	ENST00000277465	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
In-frame	ENST00000372948	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-
In-frame	ENST00000393608	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393608	CIZ1	chr9	130947825	-	ENST00000393056	DBH	chr9	136521658	-	2094	791	38	1069	343
ENST00000277465	CIZ1	chr9	130947825	-	ENST00000393056	DBH	chr9	136521658	-	1894	591	3	869	288
ENST00000372948	CIZ1	chr9	130947825	-	ENST00000393056	DBH	chr9	136521658	-	2094	791	38	1069	343

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393608	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-	0.07437167	0.92562824
ENST00000277465	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-	0.06613835	0.9338616
ENST00000372948	ENST00000393056	CIZ1	chr9	130947825	-	DBH	chr9	136521658	-	0.07437167	0.92562824

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Fusion Genomic Features for CIZ1-DBH

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CIZ1-DBH

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130947825/chr9:136521658)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CIZ1 Q9ULV3	DBH P09172
FUNCTION: May regulate the subcellular localization of CIP/WAF1.	FUNCTION: Conversion of dopamine to noradrenaline. {ECO:0000269\|PubMed:27148966, ECO:0000269\|PubMed:3443096, ECO:0000269\|PubMed:7961964, ECO:0000269\|PubMed:8546710}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000325721

4_44

172

870.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372938

4_44

196

899.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372948

4_44

196

843.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372954

4_44

172

819.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000393608

4_44

196

899.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000541172

4_44

798.0

Compositional bias

Note=Gln-rich

Tgene

DBH

chr9:130947825

chr9:136521658

ENST00000393056

57_173

618.0

Domain

DOMON

Tgene

DBH

chr9:130947825

chr9:136521658

ENST00000393056

1_16

618.0

Topological domain

Cytoplasmic

Tgene

DBH

chr9:130947825

chr9:136521658

ENST00000393056

38_617

618.0

Topological domain

Intragranular

Tgene

DBH

chr9:130947825

chr9:136521658

ENST00000393056

17_37

618.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000325721

276_470

172

870.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000325721

741_761

172

870.0

Compositional bias

Note=Glu-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372938

276_470

196

899.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372938

741_761

196

899.0

Compositional bias

Note=Glu-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372948

276_470

196

843.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372948

741_761

196

843.0

Compositional bias

Note=Glu-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372954

276_470

172

819.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372954

741_761

172

819.0

Compositional bias

Note=Glu-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000393608

276_470

196

899.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000393608

741_761

196

899.0

Compositional bias

Note=Glu-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000541172

276_470

798.0

Compositional bias

Note=Gln-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000541172

741_761

798.0

Compositional bias

Note=Glu-rich

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000325721

799_830

172

870.0

Zinc finger

Matrin-type

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372938

799_830

196

899.0

Zinc finger

Matrin-type

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372948

799_830

196

843.0

Zinc finger

Matrin-type

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000372954

799_830

172

819.0

Zinc finger

Matrin-type

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000393608

799_830

196

899.0

Zinc finger

Matrin-type

Hgene

CIZ1

chr9:130947825

chr9:136521658

ENST00000541172

799_830

798.0

Zinc finger

Matrin-type

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Fusion Gene Sequence for CIZ1-DBH

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>16877_16877_1_CIZ1-DBH_CIZ1_chr9_130947825_ENST00000277465_DBH_chr9_136521658_ENST00000393056_length(transcript)=1894nt_BP=591nt
ACCATGTTCAGCCAGCAGCAGCAGCAGCAGCTCCAGCAACAGCAGCAGCAGCTCCAGCAGTTACAGCAGCAGCAGCTCCAGCAGCAGCAA
TTGCAGCAGCAGCAGTTACTGCAGCTCCAGCAGCTGCTCCAGCAGTCCCCACCACAGGCCCCGTTGCCCATGGCTGTCAGCCGGGGGCTC
CCCCCGCAGCAGCCACAGCAGCCGCTTCTGAATCTCCAGGGCACCAACTCAGCCTCCCTCCTCAACGGCTCCATGCTGCAGAGAGCTTTG
CTTTTACAGCAGTTGCAAGGACTGGACCAGTTTGCAATGCCACCAGCCACGTATGACACTGCCGGTCTCACCATGCCCACAGCAACACTG
GGTAACCTCCGAGGCTATGGCATGGCATCCCCAGGCCTCGCAGCCCCCAGCCTCACACCCCCACAACTGGCCACTCCAAATTTGCAACAG
TTCTTTCCCCAGGCCACTCGCCAGTCCTTGCTGGGACCTCCTCCTGTTGGGGTCCCCATGAACCCTTCCCAGTTCAACCTTTCAGGACGG
AACCCCCAGAAACAGGCCCGGACCTCCTCCTCTACCACCCCCAATCGAAAGCCTGGAGGAGATGTGTGTCAACTACGTGCACTACTACCC
CCAGACGCAGCTGGAGCTCTGCAAGAGCGCTGTGGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATCAACAGGTTCAACAACGAGGA
TGTCTGCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCTTCAACCGCGACGTACTGAAGGCCCTGTA
CAGCTTCGCGCCCATCTCCATGCACTGCAACAAGTCCTCAGCCGTCCGCTTCCAGGGTGAATGGAACCTGCAGCCCCTGCCCAAGGTCAT
CTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTTGTCAGCATTGGTGGGGGCAA
AGGCTGAGGGGGGACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCACTCTACTCTGCGACGATCCCC
ATGGAACAGCCCTGCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCCAGCCTTCTTCCCCCAGGGTC
CCCTGCATGGCTGAGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCCATTTAAACCCGGCTGACTCA
GTGCAGGGACAGCCTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGTGGCCTGGCTTCTGGGACAGG
CACCATGCTGGGCCGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCAGCGGGTGCGGGTGCCGCTTA
AACATTTCCCTGCTGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCATTTAGCTAGTTAGAGACTCG
CCTGGGAAATTGCTCCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAACTATCACCAAAAGACGAGGCG
GCAAAGATCCAGCGGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCTCTGCCGGTGGGGCCAGCGCT
GAACAGACCGGGGTGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGCGGGCCATTTCACATTCCTGA
CCCTCACTTTTCTCATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAATGAGCCAATAAAGCTCACACTTGGGCTGGCACCCACTGGAGG

>16877_16877_1_CIZ1-DBH_CIZ1_chr9_130947825_ENST00000277465_DBH_chr9_136521658_ENST00000393056_length(amino acids)=288AA_BP=194
MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALL
LQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRN
PQKQARTSSSTTPNRKPGGDVCQLRALLPPDAAGALQERCGRRLPAEVLPPHQQVQQRGCLHLPSGVRVSAVHLCSLELLQPRRTEGPVQ

--------------------------------------------------------------
>16877_16877_2_CIZ1-DBH_CIZ1_chr9_130947825_ENST00000372948_DBH_chr9_136521658_ENST00000393056_length(transcript)=2094nt_BP=791nt
AACACGATTCCTCTGGCCAGGCCAAGGGGAGGGCGACACTGACAGGCGCCCCCCACCCAGGGGCCGTGGCGAAGCAAGGGGCCGGCTGCT
CAGAAAAGGATAAGAAGTGGTTTCTCCTCCCCTCTTCCCTTCCTCATCCTGCAGCCCGCGCCTCCCCCCTCGCCGCGCTGCGCACGGATG
GCGGCGGGAGCCGCAGAGCCACCATGTTCAGCCAGCAGCAGCAGCAGCAGCTCCAGCAACAGCAGCAGCAGCTCCAGCAGTTACAGCAGC
AGCAGCTCCAGCAGCAGCAATTGCAGCAGCAGCAGTTACTGCAGCTCCAGCAGCTGCTCCAGCAGTCCCCACCACAGGCCCCGTTGCCCA
TGGCTGTCAGCCGGGGGCTCCCCCCGCAGCAGCCACAGCAGCCGCTTCTGAATCTCCAGGGCACCAACTCAGCCTCCCTCCTCAACGGCT
CCATGCTGCAGAGAGCTTTGCTTTTACAGCAGTTGCAAGGACTGGACCAGTTTGCAATGCCACCAGCCACGTATGACACTGCCGGTCTCA
CCATGCCCACAGCAACACTGGGTAACCTCCGAGGCTATGGCATGGCATCCCCAGGCCTCGCAGCCCCCAGCCTCACACCCCCACAACTGG
CCACTCCAAATTTGCAACAGTTCTTTCCCCAGGCCACTCGCCAGTCCTTGCTGGGACCTCCTCCTGTTGGGGTCCCCATGAACCCTTCCC
AGTTCAACCTTTCAGGACGGAACCCCCAGAAACAGGCCCGGACCTCCTCCTCTACCACCCCCAATCGAAAGCCTGGAGGAGATGTGTGTC
AACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAGAGCGCTGTGGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATC
AACAGGTTCAACAACGAGGATGTCTGCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCTTCAACCGC
GACGTACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAACAAGTCCTCAGCCGTCCGCTTCCAGGGTGAATGGAACCTG
CAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTT
GTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCAC
TCTACTCTGCGACGATCCCCATGGAACAGCCCTGCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCC
AGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGAGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCC
ATTTAAACCCGGCTGACTCAGTGCAGGGACAGCCTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGT
GGCCTGGCTTCTGGGACAGGCACCATGCTGGGCCGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCA
GCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCTGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCA
TTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCTCCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAAC
TATCACCAAAAGACGAGGCGGCAAAGATCCAGCGGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCT
CTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGTGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGC
GGGCCATTTCACATTCCTGACCCTCACTTTTCTCATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAATGAGCCAATAAAGCTCACACTT

>16877_16877_2_CIZ1-DBH_CIZ1_chr9_130947825_ENST00000372948_DBH_chr9_136521658_ENST00000393056_length(amino acids)=343AA_BP=249
MTGAPHPGAVAKQGAGCSEKDKKWFLLPSSLPHPAARASPLAALRTDGGGSRRATMFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQL
LQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGY
GMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKPGGDVCQLRALLPPDAAGA

--------------------------------------------------------------
>16877_16877_3_CIZ1-DBH_CIZ1_chr9_130947825_ENST00000393608_DBH_chr9_136521658_ENST00000393056_length(transcript)=2094nt_BP=791nt
AACACGATTCCTCTGGCCAGGCCAAGGGGAGGGCGACACTGACAGGCGCCCCCCACCCAGGGGCCGTGGCGAAGCAAGGGGCCGGCTGCT
CAGAAAAGGATAAGAAGTGGTTTCTCCTCCCCTCTTCCCTTCCTCATCCTGCAGCCCGCGCCTCCCCCCTCGCCGCGCTGCGCACGGATG
GCGGCGGGAGCCGCAGAGCCACCATGTTCAGCCAGCAGCAGCAGCAGCAGCTCCAGCAACAGCAGCAGCAGCTCCAGCAGTTACAGCAGC
AGCAGCTCCAGCAGCAGCAATTGCAGCAGCAGCAGTTACTGCAGCTCCAGCAGCTGCTCCAGCAGTCCCCACCACAGGCCCCGTTGCCCA
TGGCTGTCAGCCGGGGGCTCCCCCCGCAGCAGCCACAGCAGCCGCTTCTGAATCTCCAGGGCACCAACTCAGCCTCCCTCCTCAACGGCT
CCATGCTGCAGAGAGCTTTGCTTTTACAGCAGTTGCAAGGACTGGACCAGTTTGCAATGCCACCAGCCACGTATGACACTGCCGGTCTCA
CCATGCCCACAGCAACACTGGGTAACCTCCGAGGCTATGGCATGGCATCCCCAGGCCTCGCAGCCCCCAGCCTCACACCCCCACAACTGG
CCACTCCAAATTTGCAACAGTTCTTTCCCCAGGCCACTCGCCAGTCCTTGCTGGGACCTCCTCCTGTTGGGGTCCCCATGAACCCTTCCC
AGTTCAACCTTTCAGGACGGAACCCCCAGAAACAGGCCCGGACCTCCTCCTCTACCACCCCCAATCGAAAGCCTGGAGGAGATGTGTGTC
AACTACGTGCACTACTACCCCCAGACGCAGCTGGAGCTCTGCAAGAGCGCTGTGGACGCCGGCTTCCTGCAGAAGTACTTCCACCTCATC
AACAGGTTCAACAACGAGGATGTCTGCACCTGCCCTCAGGCGTCCGTGTCTCAGCAGTTCACCTCTGTTCCCTGGAACTCCTTCAACCGC
GACGTACTGAAGGCCCTGTACAGCTTCGCGCCCATCTCCATGCACTGCAACAAGTCCTCAGCCGTCCGCTTCCAGGGTGAATGGAACCTG
CAGCCCCTGCCCAAGGTCATCTCCACACTGGAAGAGCCCACCCCACAGTGCCCCACCAGCCAGGGCCGAAGCCCTGCTGGCCCCACCGTT
GTCAGCATTGGTGGGGGCAAAGGCTGAGGGGGGACCTACTCCTCCCCCTCCTCCATGCTGTCCCTGTGGGCTCACACCGGCACTGTGCAC
TCTACTCTGCGACGATCCCCATGGAACAGCCCTGCACGCCCAGGATGAAGGGGCCAGACCACGCCCCTGCCTGAGACCACGGTCCAATCC
AGCCTTCTTCCCCCAGGGTCCCCTGCATGGCTGAGAGGGTGTGGGTGCCCTGTTGACCTACCCTGGACCGAGTGGACCACGACCTCGTCC
ATTTAAACCCGGCTGACTCAGTGCAGGGACAGCCTGCACAGTGGTCCAGGGTCCAGCCCTCCGCCAGCCCTGTTCCGCCTCACTGGGTGT
GGCCTGGCTTCTGGGACAGGCACCATGCTGGGCCGGGGTGTGGAATCACCGGGAACGCCCCCGCCCCCGCCCCGCTGCTCCCGGTGTGCA
GCGGGTGCGGGTGCCGCTTAAACATTTCCCTGCTGAGTGGCTCGTGTTTCACAGTGGGCGGCTTCCCTGCGACGGAGGCAGGACCAGGCA
TTTAGCTAGTTAGAGACTCGCCTGGGAAATTGCTCCATTCCTGAGTAAACAGATATTTTCGCCCACCTAAAGGGAAGCCCTGACAACAAC
TATCACCAAAAGACGAGGCGGCAAAGATCCAGCGGGGCTTCTGGGCGCCGGTTCCACGTGGGGTGGAATTATTAGCACCAGCTTGCTTCT
CTGCCGGTGGGGCCAGCGCTGAACAGACCGGGGTGGAGTCAGGGCTGTGCTTTCCGCGTGGTTCTGCCACTTAGGGAGTGTGCCTTGGGC
GGGCCATTTCACATTCCTGACCCTCACTTTTCTCATCTGTAAAACCAGGCTGATGCCGTGCGGGCTAATGAGCCAATAAAGCTCACACTT

>16877_16877_3_CIZ1-DBH_CIZ1_chr9_130947825_ENST00000393608_DBH_chr9_136521658_ENST00000393056_length(amino acids)=343AA_BP=249
MTGAPHPGAVAKQGAGCSEKDKKWFLLPSSLPHPAARASPLAALRTDGGGSRRATMFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQL
LQLQQLLQQSPPQAPLPMAVSRGLPPQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLGNLRGY
GMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRNPQKQARTSSSTTPNRKPGGDVCQLRALLPPDAAGA

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Fusion Gene PPI Analysis for CIZ1-DBH

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CIZ1-DBH

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CIZ1-DBH

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source