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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CKAP2-SMCO2 (FusionGDB2 ID:16886)

Fusion Gene Summary for CKAP2-SMCO2

check button Fusion gene summary
Fusion gene informationFusion gene name: CKAP2-SMCO2
Fusion gene ID: 16886
HgeneTgene
Gene symbol

CKAP2

SMCO2

Gene ID

26586

341346

Gene namecytoskeleton associated protein 2single-pass membrane protein with coiled-coil domains 2
SynonymsLB1|TMAP|se20-10C12orf70
Cytomap

13q14.3

12p11.23

Type of geneprotein-codingprotein-coding
Descriptioncytoskeleton-associated protein 2CTCL tumor antigen se20-10tumor- and microtubule-associated proteintumor-associated microtubule-associated proteinsingle-pass membrane and coiled-coil domain-containing protein 2
Modification date2020031320200313
UniProtAcc

Q8WWK9

.
Ensembl transtripts involved in fusion geneENST00000258607, ENST00000378037, 
ENST00000490903, ENST00000378034, 
ENST00000538647, ENST00000298876, 
ENST00000416383, ENST00000535986, 
Fusion gene scores* DoF score3 X 3 X 2=185 X 4 X 7=140
# samples 39
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/140*10)=-0.637429920615292
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CKAP2 [Title/Abstract] AND SMCO2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCKAP2(53048219)-SMCO2(27654856), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CKAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SMCO2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-D5-6926-01ACKAP2chr13

53048219

+SMCO2chr12

27654856

+


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Fusion Gene ORF analysis for CKAP2-SMCO2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000258607ENST00000538647CKAP2chr13

53048219

+SMCO2chr12

27654856

+
5CDS-intronENST00000378037ENST00000538647CKAP2chr13

53048219

+SMCO2chr12

27654856

+
5CDS-intronENST00000490903ENST00000538647CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000258607ENST00000298876CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000258607ENST00000416383CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000258607ENST00000535986CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000378037ENST00000298876CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000378037ENST00000416383CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000378037ENST00000535986CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000490903ENST00000298876CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000490903ENST00000416383CKAP2chr13

53048219

+SMCO2chr12

27654856

+
In-frameENST00000490903ENST00000535986CKAP2chr13

53048219

+SMCO2chr12

27654856

+
intron-3CDSENST00000378034ENST00000298876CKAP2chr13

53048219

+SMCO2chr12

27654856

+
intron-3CDSENST00000378034ENST00000416383CKAP2chr13

53048219

+SMCO2chr12

27654856

+
intron-3CDSENST00000378034ENST00000535986CKAP2chr13

53048219

+SMCO2chr12

27654856

+
intron-intronENST00000378034ENST00000538647CKAP2chr13

53048219

+SMCO2chr12

27654856

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000258607CKAP2chr1353048219+ENST00000416383SMCO2chr1227654856+21831920762118680
ENST00000258607CKAP2chr1353048219+ENST00000298876SMCO2chr1227654856+21831920762118680
ENST00000258607CKAP2chr1353048219+ENST00000535986SMCO2chr1227654856+21831920762118680
ENST00000378037CKAP2chr1353048219+ENST00000416383SMCO2chr1227654856+21581895482093681
ENST00000378037CKAP2chr1353048219+ENST00000298876SMCO2chr1227654856+21581895482093681
ENST00000378037CKAP2chr1353048219+ENST00000535986SMCO2chr1227654856+21581895482093681
ENST00000490903CKAP2chr1353048219+ENST00000416383SMCO2chr1227654856+220319402372138633
ENST00000490903CKAP2chr1353048219+ENST00000298876SMCO2chr1227654856+220319402372138633
ENST00000490903CKAP2chr1353048219+ENST00000535986SMCO2chr1227654856+220319402372138633

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000258607ENST00000416383CKAP2chr1353048219+SMCO2chr1227654856+0.0012772760.99872273
ENST00000258607ENST00000298876CKAP2chr1353048219+SMCO2chr1227654856+0.0012772760.99872273
ENST00000258607ENST00000535986CKAP2chr1353048219+SMCO2chr1227654856+0.0012772760.99872273
ENST00000378037ENST00000416383CKAP2chr1353048219+SMCO2chr1227654856+0.0014455390.9985544
ENST00000378037ENST00000298876CKAP2chr1353048219+SMCO2chr1227654856+0.0014455390.9985544
ENST00000378037ENST00000535986CKAP2chr1353048219+SMCO2chr1227654856+0.0014455390.9985544
ENST00000490903ENST00000416383CKAP2chr1353048219+SMCO2chr1227654856+0.0027308260.9972691
ENST00000490903ENST00000298876CKAP2chr1353048219+SMCO2chr1227654856+0.0027308260.9972691
ENST00000490903ENST00000535986CKAP2chr1353048219+SMCO2chr1227654856+0.0027308260.9972691

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Fusion Genomic Features for CKAP2-SMCO2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CKAP2chr1353048219+SMCO2chr1227654855+0.0369436330.9630563
CKAP2chr1353048219+SMCO2chr1227654855+0.0369436330.9630563

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CKAP2-SMCO2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:53048219/chr12:27654856)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CKAP2

Q8WWK9

.
FUNCTION: Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMCO2chr13:53048219chr12:27654856ENST0000041638379284_304277344.0TransmembraneHelical
TgeneSMCO2chr13:53048219chr12:27654856ENST0000053598668284_304277344.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSMCO2chr13:53048219chr12:27654856ENST0000041638379152_238277344.0Coiled coilOntology_term=ECO:0000255
TgeneSMCO2chr13:53048219chr12:27654856ENST0000053598668152_238277344.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for CKAP2-SMCO2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16886_16886_1_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000258607_SMCO2_chr12_27654856_ENST00000298876_length(transcript)=2183nt_BP=1920nt
GGAGACGGCAGCCGCGCCGTCTGACGGCTTAGCCGCGGTGCAGACTGCGGCGGCGGTGGTCTGAGGAAGTTCTATCTTGGCGCTAAAGCG
GAGACGCATCCCCCGACCCGAGGCTACGATGAGCACACCGGCCGTGCCCCAGGACCTGCAGCTGCCCCCGAGTCAGAGGGCGCAGTCCGC
ATTCAAAGAGCAAAGAAGACAAAAACTCAAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAGCAGGAAAATGAGATGTTATC
CAGTAGAGATCAGAGAGTTGTGACATCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAAACAAAAATGGCTGATAAAGA
AAACATGAAGAGACCTGCAGAGAGCAAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCTTCAAATGAACTAACCAATTC
AACTGTAGTAATTGACACACATAAACCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGATGATCCCCAAAGTCAACATAT
GACATTAAGCCAGGCATTTCACCTTAAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAGCAAGATGCTAACATGCCCAA
GAAACCTGTGCTTGGATCTTATCGTGGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTACAAGTCAAAGATGAGAGTTC
TGCAGCAACAAAGAAACTTTCAGCCACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGTGTAACAGTGAAAAGTAATAG
ATCCTCCAATATGACTGCCACTACTAAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCTCCTATTAGAAGTCATCACAG
TAATACCCGGGACACTGTGAAACAAGGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCTCATGAAAAAGAACTATTACA
ATCAAAAACAGCTTTATCTAGTGTCAAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCAAGATCCATAGCATCTGAAGT
TATAGCCAGGCCTGCTTCATTGTCTAATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGACATACTGCAGGAAAAGCAAT
TGTTGATAGTAGATCAGCTCAGCCCAAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAAGCTGGCAAAGGAAGAGTGCT
AAAAAGGCCCCCTAATTCAGTAGTTACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCTTTTTGGACTACCATGGCAGA
AGAAGATGAACAAAGATTATTTACTGAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAATGAGGGATGTCCAAAAGAAGA
TATACTGGTCACACTGAATGACCTGATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATATGTCTTGCACTTATTGAACC
AATCACAAGTCCTATTGAAAATATTATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATTGAAGAGATGCGACACACGAT
TGTAGATATTCTAACAATGAAGAGTCAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCAAGCAAGGAAGAAGTCAAAGA
AGTCAGTATTGAAGATACAGGTGTTGATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGAAATTTGCTATTTCAAGATTG
TGAAAAAGAGCAAGACAACAAAACAAAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGGACAAGTTGCTTAATTAAATA
TAATGTGTCTACTACGCCATACTTGCAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATG
TTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGAT
GAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTCTCACCAG

>16886_16886_1_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000258607_SMCO2_chr12_27654856_ENST00000298876_length(amino acids)=680AA_BP=612
MALKRRRIPRPEATMSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSRDQRVVTSEDQVQEGTKVLKLKTK
MADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQD
ANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPI
RSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHT
AGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEG
CPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASK
EEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLTV

--------------------------------------------------------------
>16886_16886_2_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000258607_SMCO2_chr12_27654856_ENST00000416383_length(transcript)=2183nt_BP=1920nt
GGAGACGGCAGCCGCGCCGTCTGACGGCTTAGCCGCGGTGCAGACTGCGGCGGCGGTGGTCTGAGGAAGTTCTATCTTGGCGCTAAAGCG
GAGACGCATCCCCCGACCCGAGGCTACGATGAGCACACCGGCCGTGCCCCAGGACCTGCAGCTGCCCCCGAGTCAGAGGGCGCAGTCCGC
ATTCAAAGAGCAAAGAAGACAAAAACTCAAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAGCAGGAAAATGAGATGTTATC
CAGTAGAGATCAGAGAGTTGTGACATCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAAACAAAAATGGCTGATAAAGA
AAACATGAAGAGACCTGCAGAGAGCAAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCTTCAAATGAACTAACCAATTC
AACTGTAGTAATTGACACACATAAACCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGATGATCCCCAAAGTCAACATAT
GACATTAAGCCAGGCATTTCACCTTAAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAGCAAGATGCTAACATGCCCAA
GAAACCTGTGCTTGGATCTTATCGTGGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTACAAGTCAAAGATGAGAGTTC
TGCAGCAACAAAGAAACTTTCAGCCACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGTGTAACAGTGAAAAGTAATAG
ATCCTCCAATATGACTGCCACTACTAAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCTCCTATTAGAAGTCATCACAG
TAATACCCGGGACACTGTGAAACAAGGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCTCATGAAAAAGAACTATTACA
ATCAAAAACAGCTTTATCTAGTGTCAAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCAAGATCCATAGCATCTGAAGT
TATAGCCAGGCCTGCTTCATTGTCTAATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGACATACTGCAGGAAAAGCAAT
TGTTGATAGTAGATCAGCTCAGCCCAAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAAGCTGGCAAAGGAAGAGTGCT
AAAAAGGCCCCCTAATTCAGTAGTTACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCTTTTTGGACTACCATGGCAGA
AGAAGATGAACAAAGATTATTTACTGAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAATGAGGGATGTCCAAAAGAAGA
TATACTGGTCACACTGAATGACCTGATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATATGTCTTGCACTTATTGAACC
AATCACAAGTCCTATTGAAAATATTATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATTGAAGAGATGCGACACACGAT
TGTAGATATTCTAACAATGAAGAGTCAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCAAGCAAGGAAGAAGTCAAAGA
AGTCAGTATTGAAGATACAGGTGTTGATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGAAATTTGCTATTTCAAGATTG
TGAAAAAGAGCAAGACAACAAAACAAAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGGACAAGTTGCTTAATTAAATA
TAATGTGTCTACTACGCCATACTTGCAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATG
TTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGAT
GAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTCTCACCAG

>16886_16886_2_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000258607_SMCO2_chr12_27654856_ENST00000416383_length(amino acids)=680AA_BP=612
MALKRRRIPRPEATMSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSRDQRVVTSEDQVQEGTKVLKLKTK
MADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQD
ANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPI
RSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHT
AGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEG
CPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASK
EEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLTV

--------------------------------------------------------------
>16886_16886_3_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000258607_SMCO2_chr12_27654856_ENST00000535986_length(transcript)=2183nt_BP=1920nt
GGAGACGGCAGCCGCGCCGTCTGACGGCTTAGCCGCGGTGCAGACTGCGGCGGCGGTGGTCTGAGGAAGTTCTATCTTGGCGCTAAAGCG
GAGACGCATCCCCCGACCCGAGGCTACGATGAGCACACCGGCCGTGCCCCAGGACCTGCAGCTGCCCCCGAGTCAGAGGGCGCAGTCCGC
ATTCAAAGAGCAAAGAAGACAAAAACTCAAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAGCAGGAAAATGAGATGTTATC
CAGTAGAGATCAGAGAGTTGTGACATCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAAACAAAAATGGCTGATAAAGA
AAACATGAAGAGACCTGCAGAGAGCAAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCTTCAAATGAACTAACCAATTC
AACTGTAGTAATTGACACACATAAACCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGATGATCCCCAAAGTCAACATAT
GACATTAAGCCAGGCATTTCACCTTAAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAGCAAGATGCTAACATGCCCAA
GAAACCTGTGCTTGGATCTTATCGTGGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTACAAGTCAAAGATGAGAGTTC
TGCAGCAACAAAGAAACTTTCAGCCACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGTGTAACAGTGAAAAGTAATAG
ATCCTCCAATATGACTGCCACTACTAAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCTCCTATTAGAAGTCATCACAG
TAATACCCGGGACACTGTGAAACAAGGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCTCATGAAAAAGAACTATTACA
ATCAAAAACAGCTTTATCTAGTGTCAAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCAAGATCCATAGCATCTGAAGT
TATAGCCAGGCCTGCTTCATTGTCTAATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGACATACTGCAGGAAAAGCAAT
TGTTGATAGTAGATCAGCTCAGCCCAAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAAGCTGGCAAAGGAAGAGTGCT
AAAAAGGCCCCCTAATTCAGTAGTTACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCTTTTTGGACTACCATGGCAGA
AGAAGATGAACAAAGATTATTTACTGAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAATGAGGGATGTCCAAAAGAAGA
TATACTGGTCACACTGAATGACCTGATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATATGTCTTGCACTTATTGAACC
AATCACAAGTCCTATTGAAAATATTATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATTGAAGAGATGCGACACACGAT
TGTAGATATTCTAACAATGAAGAGTCAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCAAGCAAGGAAGAAGTCAAAGA
AGTCAGTATTGAAGATACAGGTGTTGATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGAAATTTGCTATTTCAAGATTG
TGAAAAAGAGCAAGACAACAAAACAAAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGGACAAGTTGCTTAATTAAATA
TAATGTGTCTACTACGCCATACTTGCAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATG
TTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGAT
GAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCACCCTACTGACTTTCTCACCAG

>16886_16886_3_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000258607_SMCO2_chr12_27654856_ENST00000535986_length(amino acids)=680AA_BP=612
MALKRRRIPRPEATMSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSRDQRVVTSEDQVQEGTKVLKLKTK
MADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQD
ANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPI
RSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHT
AGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEG
CPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASK
EEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLTV

--------------------------------------------------------------
>16886_16886_4_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000378037_SMCO2_chr12_27654856_ENST00000298876_length(transcript)=2158nt_BP=1895nt
TTAGCCGCGGTGCAGACTGCGGCGGCGGTGGTCTGAGGAAGTTCTATCTTGGCGCTAAAGCGGAGACGCATCCCCCGACCCGAGGCTACG
ATGAGCACACCGGCCGTGCCCCAGGACCTGCAGCTGCCCCCGAGTCAGAGGGCGCAGTCCGCATTCAAAGAGCAAAGAAGACAAAAACTC
AAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAGCAGGAAAATGAGATGTTATCCAGTAGTAGAGATCAGAGAGTTGTGACA
TCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAAACAAAAATGGCTGATAAAGAAAACATGAAGAGACCTGCAGAGAGC
AAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCTTCAAATGAACTAACCAATTCAACTGTAGTAATTGACACACATAAA
CCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGATGATCCCCAAAGTCAACATATGACATTAAGCCAGGCATTTCACCTT
AAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAGCAAGATGCTAACATGCCCAAGAAACCTGTGCTTGGATCTTATCGT
GGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTACAAGTCAAAGATGAGAGTTCTGCAGCAACAAAGAAACTTTCAGCC
ACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGTGTAACAGTGAAAAGTAATAGATCCTCCAATATGACTGCCACTACT
AAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCTCCTATTAGAAGTCATCACAGTAATACCCGGGACACTGTGAAACAA
GGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCTCATGAAAAAGAACTATTACAATCAAAAACAGCTTTATCTAGTGTC
AAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCAAGATCCATAGCATCTGAAGTTATAGCCAGGCCTGCTTCATTGTCT
AATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGACATACTGCAGGAAAAGCAATTGTTGATAGTAGATCAGCTCAGCCC
AAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAAGCTGGCAAAGGAAGAGTGCTAAAAAGGCCCCCTAATTCAGTAGTT
ACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCTTTTTGGACTACCATGGCAGAAGAAGATGAACAAAGATTATTTACT
GAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAATGAGGGATGTCCAAAAGAAGATATACTGGTCACACTGAATGACCTG
ATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATATGTCTTGCACTTATTGAACCAATCACAAGTCCTATTGAAAATATT
ATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATTGAAGAGATGCGACACACGATTGTAGATATTCTAACAATGAAGAGT
CAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCAAGCAAGGAAGAAGTCAAAGAAGTCAGTATTGAAGATACAGGTGTT
GATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGAAATTTGCTATTTCAAGATTGTGAAAAAGAGCAAGACAACAAAACA
AAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGGACAAGTTGCTTAATTAAATATAATGTGTCTACTACGCCATACTTG
CAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACA
TTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAA

>16886_16886_4_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000378037_SMCO2_chr12_27654856_ENST00000298876_length(amino acids)=681AA_BP=613
MALKRRRIPRPEATMSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSSRDQRVVTSEDQVQEGTKVLKLKT
KMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQ
DANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPP
IRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRH
TAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINE
GCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCAS
KEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLT

--------------------------------------------------------------
>16886_16886_5_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000378037_SMCO2_chr12_27654856_ENST00000416383_length(transcript)=2158nt_BP=1895nt
TTAGCCGCGGTGCAGACTGCGGCGGCGGTGGTCTGAGGAAGTTCTATCTTGGCGCTAAAGCGGAGACGCATCCCCCGACCCGAGGCTACG
ATGAGCACACCGGCCGTGCCCCAGGACCTGCAGCTGCCCCCGAGTCAGAGGGCGCAGTCCGCATTCAAAGAGCAAAGAAGACAAAAACTC
AAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAGCAGGAAAATGAGATGTTATCCAGTAGTAGAGATCAGAGAGTTGTGACA
TCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAAACAAAAATGGCTGATAAAGAAAACATGAAGAGACCTGCAGAGAGC
AAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCTTCAAATGAACTAACCAATTCAACTGTAGTAATTGACACACATAAA
CCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGATGATCCCCAAAGTCAACATATGACATTAAGCCAGGCATTTCACCTT
AAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAGCAAGATGCTAACATGCCCAAGAAACCTGTGCTTGGATCTTATCGT
GGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTACAAGTCAAAGATGAGAGTTCTGCAGCAACAAAGAAACTTTCAGCC
ACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGTGTAACAGTGAAAAGTAATAGATCCTCCAATATGACTGCCACTACT
AAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCTCCTATTAGAAGTCATCACAGTAATACCCGGGACACTGTGAAACAA
GGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCTCATGAAAAAGAACTATTACAATCAAAAACAGCTTTATCTAGTGTC
AAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCAAGATCCATAGCATCTGAAGTTATAGCCAGGCCTGCTTCATTGTCT
AATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGACATACTGCAGGAAAAGCAATTGTTGATAGTAGATCAGCTCAGCCC
AAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAAGCTGGCAAAGGAAGAGTGCTAAAAAGGCCCCCTAATTCAGTAGTT
ACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCTTTTTGGACTACCATGGCAGAAGAAGATGAACAAAGATTATTTACT
GAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAATGAGGGATGTCCAAAAGAAGATATACTGGTCACACTGAATGACCTG
ATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATATGTCTTGCACTTATTGAACCAATCACAAGTCCTATTGAAAATATT
ATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATTGAAGAGATGCGACACACGATTGTAGATATTCTAACAATGAAGAGT
CAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCAAGCAAGGAAGAAGTCAAAGAAGTCAGTATTGAAGATACAGGTGTT
GATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGAAATTTGCTATTTCAAGATTGTGAAAAAGAGCAAGACAACAAAACA
AAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGGACAAGTTGCTTAATTAAATATAATGTGTCTACTACGCCATACTTG
CAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACA
TTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAA

>16886_16886_5_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000378037_SMCO2_chr12_27654856_ENST00000416383_length(amino acids)=681AA_BP=613
MALKRRRIPRPEATMSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSSRDQRVVTSEDQVQEGTKVLKLKT
KMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQ
DANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPP
IRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRH
TAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINE
GCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCAS
KEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLT

--------------------------------------------------------------
>16886_16886_6_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000378037_SMCO2_chr12_27654856_ENST00000535986_length(transcript)=2158nt_BP=1895nt
TTAGCCGCGGTGCAGACTGCGGCGGCGGTGGTCTGAGGAAGTTCTATCTTGGCGCTAAAGCGGAGACGCATCCCCCGACCCGAGGCTACG
ATGAGCACACCGGCCGTGCCCCAGGACCTGCAGCTGCCCCCGAGTCAGAGGGCGCAGTCCGCATTCAAAGAGCAAAGAAGACAAAAACTC
AAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAGCAGGAAAATGAGATGTTATCCAGTAGTAGAGATCAGAGAGTTGTGACA
TCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAAACAAAAATGGCTGATAAAGAAAACATGAAGAGACCTGCAGAGAGC
AAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCTTCAAATGAACTAACCAATTCAACTGTAGTAATTGACACACATAAA
CCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGATGATCCCCAAAGTCAACATATGACATTAAGCCAGGCATTTCACCTT
AAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAGCAAGATGCTAACATGCCCAAGAAACCTGTGCTTGGATCTTATCGT
GGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTACAAGTCAAAGATGAGAGTTCTGCAGCAACAAAGAAACTTTCAGCC
ACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGTGTAACAGTGAAAAGTAATAGATCCTCCAATATGACTGCCACTACT
AAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCTCCTATTAGAAGTCATCACAGTAATACCCGGGACACTGTGAAACAA
GGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCTCATGAAAAAGAACTATTACAATCAAAAACAGCTTTATCTAGTGTC
AAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCAAGATCCATAGCATCTGAAGTTATAGCCAGGCCTGCTTCATTGTCT
AATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGACATACTGCAGGAAAAGCAATTGTTGATAGTAGATCAGCTCAGCCC
AAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAAGCTGGCAAAGGAAGAGTGCTAAAAAGGCCCCCTAATTCAGTAGTT
ACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCTTTTTGGACTACCATGGCAGAAGAAGATGAACAAAGATTATTTACT
GAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAATGAGGGATGTCCAAAAGAAGATATACTGGTCACACTGAATGACCTG
ATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATATGTCTTGCACTTATTGAACCAATCACAAGTCCTATTGAAAATATT
ATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATTGAAGAGATGCGACACACGATTGTAGATATTCTAACAATGAAGAGT
CAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCAAGCAAGGAAGAAGTCAAAGAAGTCAGTATTGAAGATACAGGTGTT
GATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGAAATTTGCTATTTCAAGATTGTGAAAAAGAGCAAGACAACAAAACA
AAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGGACAAGTTGCTTAATTAAATATAATGTGTCTACTACGCCATACTTG
CAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTCACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACA
TTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACCACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAA

>16886_16886_6_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000378037_SMCO2_chr12_27654856_ENST00000535986_length(amino acids)=681AA_BP=613
MALKRRRIPRPEATMSTPAVPQDLQLPPSQRAQSAFKEQRRQKLKEHLLRRKTLFAYKQENEMLSSSRDQRVVTSEDQVQEGTKVLKLKT
KMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDSNQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQ
DANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPKATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPP
IRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSSSQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRH
TAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHEPAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINE
GCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIYEKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCAS
KEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPTHDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLT

--------------------------------------------------------------
>16886_16886_7_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000490903_SMCO2_chr12_27654856_ENST00000298876_length(transcript)=2203nt_BP=1940nt
TGCGCCTGCGCTGGGTCCTCCGCCTCTTAGGTCCCTAGCGAATTTCTGCAGGGCTGGGGTCGCATCATGTGTTATTTCCAATTTCACAGC
TTCTCCTTCGACTTTATGGAAACCGAGGGTTGGTTGGGTCTTCAAAACTAATATTGTTATTCCCTTATTCTACACACGGGAAAGCAGAAG
AAAGTAATTCTCATCTAACCCAGTTCTGAGCAAAGAAGACAAAAACTCAAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAG
CAGGAAAATGAGATGTTATCCAGTAGAGATCAGAGAGTTGTGACATCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAA
ACAAAAATGGCTGATAAAGAAAACATGAAGAGACCTGCAGAGAGCAAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCT
TCAAATGAACTAACCAATTCAACTGTAGTAATTGACACACATAAACCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGAT
GATCCCCAAAGTCAACATATGACATTAAGCCAGGCATTTCACCTTAAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAG
CAAGATGCTAACATGCCCAAGAAACCTGTGCTTGGATCTTATCGTGGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTA
CAAGTCAAAGATGAGAGTTCTGCAGCAACAAAGAAACTTTCAGCCACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGT
GTAACAGTGAAAAGTAATAGATCCTCCAATATGACTGCCACTACTAAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCT
CCTATTAGAAGTCATCACAGTAATACCCGGGACACTGTGAAACAAGGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCT
CATGAAAAAGAACTATTACAATCAAAAACAGCTTTATCTAGTGTCAAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCA
AGATCCATAGCATCTGAAGTTATAGCCAGGCCTGCTTCATTGTCTAATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGA
CATACTGCAGGAAAAGCAATTGTTGATAGTAGATCAGCTCAGCCCAAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAA
GCTGGCAAAGGAAGAGTGCTAAAAAGGCCCCCTAATTCAGTAGTTACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCT
TTTTGGACTACCATGGCAGAAGAAGATGAACAAAGATTATTTACTGAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAAT
GAGGGATGTCCAAAAGAAGATATACTGGTCACACTGAATGACCTGATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATA
TGTCTTGCACTTATTGAACCAATCACAAGTCCTATTGAAAATATTATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATT
GAAGAGATGCGACACACGATTGTAGATATTCTAACAATGAAGAGTCAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCA
AGCAAGGAAGAAGTCAAAGAAGTCAGTATTGAAGATACAGGTGTTGATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGA
AATTTGCTATTTCAAGATTGTGAAAAAGAGCAAGACAACAAAACAAAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGG
ACAAGTTGCTTAATTAAATATAATGTGTCTACTACGCCATACTTGCAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTC
ACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACC
ACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCAC

>16886_16886_7_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000490903_SMCO2_chr12_27654856_ENST00000298876_length(amino acids)=633AA_BP=565
MLRRKTLFAYKQENEMLSSRDQRVVTSEDQVQEGTKVLKLKTKMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDS
NQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQDANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPK
ATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPIRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSS
SQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHTAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHE
PAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEGCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIY
EKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASKEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPT
HDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNLEVEAL

--------------------------------------------------------------
>16886_16886_8_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000490903_SMCO2_chr12_27654856_ENST00000416383_length(transcript)=2203nt_BP=1940nt
TGCGCCTGCGCTGGGTCCTCCGCCTCTTAGGTCCCTAGCGAATTTCTGCAGGGCTGGGGTCGCATCATGTGTTATTTCCAATTTCACAGC
TTCTCCTTCGACTTTATGGAAACCGAGGGTTGGTTGGGTCTTCAAAACTAATATTGTTATTCCCTTATTCTACACACGGGAAAGCAGAAG
AAAGTAATTCTCATCTAACCCAGTTCTGAGCAAAGAAGACAAAAACTCAAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAG
CAGGAAAATGAGATGTTATCCAGTAGAGATCAGAGAGTTGTGACATCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAA
ACAAAAATGGCTGATAAAGAAAACATGAAGAGACCTGCAGAGAGCAAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCT
TCAAATGAACTAACCAATTCAACTGTAGTAATTGACACACATAAACCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGAT
GATCCCCAAAGTCAACATATGACATTAAGCCAGGCATTTCACCTTAAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAG
CAAGATGCTAACATGCCCAAGAAACCTGTGCTTGGATCTTATCGTGGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTA
CAAGTCAAAGATGAGAGTTCTGCAGCAACAAAGAAACTTTCAGCCACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGT
GTAACAGTGAAAAGTAATAGATCCTCCAATATGACTGCCACTACTAAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCT
CCTATTAGAAGTCATCACAGTAATACCCGGGACACTGTGAAACAAGGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCT
CATGAAAAAGAACTATTACAATCAAAAACAGCTTTATCTAGTGTCAAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCA
AGATCCATAGCATCTGAAGTTATAGCCAGGCCTGCTTCATTGTCTAATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGA
CATACTGCAGGAAAAGCAATTGTTGATAGTAGATCAGCTCAGCCCAAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAA
GCTGGCAAAGGAAGAGTGCTAAAAAGGCCCCCTAATTCAGTAGTTACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCT
TTTTGGACTACCATGGCAGAAGAAGATGAACAAAGATTATTTACTGAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAAT
GAGGGATGTCCAAAAGAAGATATACTGGTCACACTGAATGACCTGATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATA
TGTCTTGCACTTATTGAACCAATCACAAGTCCTATTGAAAATATTATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATT
GAAGAGATGCGACACACGATTGTAGATATTCTAACAATGAAGAGTCAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCA
AGCAAGGAAGAAGTCAAAGAAGTCAGTATTGAAGATACAGGTGTTGATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGA
AATTTGCTATTTCAAGATTGTGAAAAAGAGCAAGACAACAAAACAAAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGG
ACAAGTTGCTTAATTAAATATAATGTGTCTACTACGCCATACTTGCAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTC
ACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACC
ACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCAC

>16886_16886_8_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000490903_SMCO2_chr12_27654856_ENST00000416383_length(amino acids)=633AA_BP=565
MLRRKTLFAYKQENEMLSSRDQRVVTSEDQVQEGTKVLKLKTKMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDS
NQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQDANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPK
ATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPIRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSS
SQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHTAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHE
PAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEGCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIY
EKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASKEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPT
HDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNLEVEAL

--------------------------------------------------------------
>16886_16886_9_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000490903_SMCO2_chr12_27654856_ENST00000535986_length(transcript)=2203nt_BP=1940nt
TGCGCCTGCGCTGGGTCCTCCGCCTCTTAGGTCCCTAGCGAATTTCTGCAGGGCTGGGGTCGCATCATGTGTTATTTCCAATTTCACAGC
TTCTCCTTCGACTTTATGGAAACCGAGGGTTGGTTGGGTCTTCAAAACTAATATTGTTATTCCCTTATTCTACACACGGGAAAGCAGAAG
AAAGTAATTCTCATCTAACCCAGTTCTGAGCAAAGAAGACAAAAACTCAAGGAACATCTGTTGAGAAGAAAAACGCTTTTTGCATACAAG
CAGGAAAATGAGATGTTATCCAGTAGAGATCAGAGAGTTGTGACATCTGAGGACCAAGTTCAAGAAGGGACTAAAGTGCTGAAACTTAAA
ACAAAAATGGCTGATAAAGAAAACATGAAGAGACCTGCAGAGAGCAAAAATAATACAGTGGTGGGGAAACATTGTATTCCTTTAAAACCT
TCAAATGAACTAACCAATTCAACTGTAGTAATTGACACACATAAACCTAAGGATAGTAATCAAACTCCGCATTTGTTACTAACTGAAGAT
GATCCCCAAAGTCAACATATGACATTAAGCCAGGCATTTCACCTTAAAAACAATAGTAAAAAGAAACAAATGACTACAGAAAAACAAAAG
CAAGATGCTAACATGCCCAAGAAACCTGTGCTTGGATCTTATCGTGGCCAGATTGTTCAGTCTAAGATTAATTCATTTAGAAAACCTCTA
CAAGTCAAAGATGAGAGTTCTGCAGCAACAAAGAAACTTTCAGCCACTATACCTAAAGCCACAAAACCTCAGCCTGTAAACACCAGCAGT
GTAACAGTGAAAAGTAATAGATCCTCCAATATGACTGCCACTACTAAATTTGTGAGCACTACATCTCAGAACACACAACTTGTGCGACCT
CCTATTAGAAGTCATCACAGTAATACCCGGGACACTGTGAAACAAGGCATCAGTAGAACTTCTGCCAATGTTACAATCCGGAAAGGGCCT
CATGAAAAAGAACTATTACAATCAAAAACAGCTTTATCTAGTGTCAAAACCAGTTCTTCTCAAGGTATAATAAGAAATAAGACTCTATCA
AGATCCATAGCATCTGAAGTTATAGCCAGGCCTGCTTCATTGTCTAATGATAAACTGATGGAAAAGTCAGAGCCCGTTGACCAGCGAAGA
CATACTGCAGGAAAAGCAATTGTTGATAGTAGATCAGCTCAGCCCAAAGAAACCTCGGAAGAGAGAAAAGCTCGTCTGAGTGAGTGGAAA
GCTGGCAAAGGAAGAGTGCTAAAAAGGCCCCCTAATTCAGTAGTTACTCAGCATGAGCCTGCAGGACAAAATGAAAAACCAGTTGGGTCT
TTTTGGACTACCATGGCAGAAGAAGATGAACAAAGATTATTTACTGAAAAAGTAAACAACACATTTTCTGAATGCCTGAACTTGATTAAT
GAGGGATGTCCAAAAGAAGATATACTGGTCACACTGAATGACCTGATTAAAAATATTCCAGATGCCAAAAAGCTTGTTAAGTATTGGATA
TGTCTTGCACTTATTGAACCAATCACAAGTCCTATTGAAAATATTATTGCAATCTATGAGAAAGCCATTCTGGCAGGGGCTCAGCCTATT
GAAGAGATGCGACACACGATTGTAGATATTCTAACAATGAAGAGTCAAGAAAAAGCTAATTTAGGAGAAAATATGGAGAAGTCTTGTGCA
AGCAAGGAAGAAGTCAAAGAAGTCAGTATTGAAGATACAGGTGTTGATGTAGATCCAGAAAAACTGGAAATGGAGAGTAAACTTCATAGA
AATTTGCTATTTCAAGATTGTGAAAAAGAGCAAGACAACAAAACAAAAGATCCAACCCATGATGTTAAAACCCCCAATACAGAAACGAGG
ACAAGTTGCTTAATTAAATATAATGTGTCTACTACGCCATACTTGCAAAGGAAACGTGCACTGAGGATTTTCATCATGTTTGATGTCCTC
ACCGTCACTGGACTTTTATGTTACATACTATTTTTTGGTGCTACATTTCTCTTTGAAAGGGTGCTTCTGAGAATGCTTGGGTGCCGCACC
ACATGGGACCTACGGGAGATGAGAGAGCCTTTCTTGAATTTGGAAGTGGAAGCCTTGTTACCCTCCTAAAGATACAGAAGTTACTGTCAC

>16886_16886_9_CKAP2-SMCO2_CKAP2_chr13_53048219_ENST00000490903_SMCO2_chr12_27654856_ENST00000535986_length(amino acids)=633AA_BP=565
MLRRKTLFAYKQENEMLSSRDQRVVTSEDQVQEGTKVLKLKTKMADKENMKRPAESKNNTVVGKHCIPLKPSNELTNSTVVIDTHKPKDS
NQTPHLLLTEDDPQSQHMTLSQAFHLKNNSKKKQMTTEKQKQDANMPKKPVLGSYRGQIVQSKINSFRKPLQVKDESSAATKKLSATIPK
ATKPQPVNTSSVTVKSNRSSNMTATTKFVSTTSQNTQLVRPPIRSHHSNTRDTVKQGISRTSANVTIRKGPHEKELLQSKTALSSVKTSS
SQGIIRNKTLSRSIASEVIARPASLSNDKLMEKSEPVDQRRHTAGKAIVDSRSAQPKETSEERKARLSEWKAGKGRVLKRPPNSVVTQHE
PAGQNEKPVGSFWTTMAEEDEQRLFTEKVNNTFSECLNLINEGCPKEDILVTLNDLIKNIPDAKKLVKYWICLALIEPITSPIENIIAIY
EKAILAGAQPIEEMRHTIVDILTMKSQEKANLGENMEKSCASKEEVKEVSIEDTGVDVDPEKLEMESKLHRNLLFQDCEKEQDNKTKDPT
HDVKTPNTETRTSCLIKYNVSTTPYLQRKRALRIFIMFDVLTVTGLLCYILFFGATFLFERVLLRMLGCRTTWDLREMREPFLNLEVEAL

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Fusion Gene PPI Analysis for CKAP2-SMCO2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CKAP2-SMCO2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CKAP2-SMCO2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource