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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CKS1B-ADAM15 (FusionGDB2 ID:16921)

Fusion Gene Summary for CKS1B-ADAM15

check button Fusion gene summary
Fusion gene informationFusion gene name: CKS1B-ADAM15
Fusion gene ID: 16921
HgeneTgene
Gene symbol

CKS1B

ADAM15

Gene ID

1163

8751

Gene nameCDC28 protein kinase regulatory subunit 1BADAM metallopeptidase domain 15
SynonymsCKS1|PNAS-16|PNAS-18|ckshs1MDC15
Cytomap

1q21.3

1q21.3

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinases regulatory subunit 1CDC2-associated protein CKS1CDC28 protein kinase 1BNB4 apoptosis/differentiation related proteincell division control protein CKS1disintegrin and metalloproteinase domain-containing protein 15MDC-15a disintegrin and metalloproteinase domain 15 (metargidin)metalloprotease RGD disintegrin proteinmetalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Modification date2020031320200320
UniProtAcc

P61024

Q13444

Ensembl transtripts involved in fusion geneENST00000308987, ENST00000368436, 
ENST00000368439, ENST00000471245, 
ENST00000600888, 		ENST00000472434, 
ENST00000447332, ENST00000271836, 
ENST00000355956, ENST00000356955, 
ENST00000359280, ENST00000360674, 
ENST00000368410, ENST00000368412, 
ENST00000368413, ENST00000449910, 
ENST00000531455, 
Fusion gene scores* DoF score4 X 4 X 3=483 X 3 X 3=27
# samples 53
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CKS1B [Title/Abstract] AND ADAM15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCKS1B(154947280)-ADAM15(155034720), # samples:1
Anticipated loss of major functional domain due to fusion event.CKS1B-ADAM15 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CKS1B-ADAM15 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADAM15

GO:0002418

immune response to tumor cell

22505472

TgeneADAM15

GO:0006915

apoptotic process

22505472

TgeneADAM15

GO:0045087

innate immune response

22505472

TgeneADAM15

GO:1904628

cellular response to phorbol 13-acetate 12-myristate

22505472


check buttonFusion gene breakpoints across CKS1B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0800CKS1Bchr1

154947280

+ADAM15chr1

155034720

+


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Fusion Gene ORF analysis for CKS1B-ADAM15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000308987ENST00000472434CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5CDS-3UTRENST00000368436ENST00000472434CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5CDS-intronENST00000308987ENST00000447332CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5CDS-intronENST00000368436ENST00000447332CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000271836CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000355956CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000356955CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000359280CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000360674CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000368410CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000368412CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000368413CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000449910CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3CDSENST00000368439ENST00000531455CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-3UTRENST00000368439ENST00000472434CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
5UTR-intronENST00000368439ENST00000447332CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000271836CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000355956CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000356955CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000359280CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000368410CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000368413CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000449910CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000308987ENST00000531455CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000271836CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000355956CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000356955CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000359280CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000368410CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000368413CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000449910CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
Frame-shiftENST00000368436ENST00000531455CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
In-frameENST00000308987ENST00000360674CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
In-frameENST00000308987ENST00000368412CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
In-frameENST00000368436ENST00000360674CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
In-frameENST00000368436ENST00000368412CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000271836CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000355956CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000356955CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000359280CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000360674CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000368410CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000368412CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000368413CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000449910CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000471245ENST00000531455CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000271836CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000355956CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000356955CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000359280CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000360674CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000368410CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000368412CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000368413CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000449910CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3CDSENST00000600888ENST00000531455CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3UTRENST00000471245ENST00000472434CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-3UTRENST00000600888ENST00000472434CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-intronENST00000471245ENST00000447332CKS1Bchr1

154947280

+ADAM15chr1

155034720

+
intron-intronENST00000600888ENST00000447332CKS1Bchr1

154947280

+ADAM15chr1

155034720

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CKS1B-ADAM15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CKS1Bchr1154947280+ADAM15chr1155034720+0.0254051820.9745949
CKS1Bchr1154947280+ADAM15chr1155034720+0.0254051820.9745949

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CKS1B-ADAM15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:154947280/chr1:155034720)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CKS1B

P61024

ADAM15

Q13444

FUNCTION: Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.FUNCTION: Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333, ECO:0000269|PubMed:18434311}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114509_656465521.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114657_685465521.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821815_821759815.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821850_856759815.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922815_821784840.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922850_856784840.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023815_821808864.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023850_856808864.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922815_821783839.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922850_856783839.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720815_821735812.6666666666666MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720850_856735812.6666666666666MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821815_821759836.6666666666666MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821850_856759836.6666666666666MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114484_486465521.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114815_821465521.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114850_856465521.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023815_821807863.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023850_856807863.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821815_821769825.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821850_856769825.0MotifSH3-binding
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114718_863465521.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114697_717465521.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821509_656759815.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922509_656784840.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023509_656808864.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922509_656783839.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720509_656735812.6666666666666Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821509_656759836.6666666666666Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023509_656807863.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821509_656769825.0Compositional biasNote=Cys-rich
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821213_414759815.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821421_508759815.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821657_685759815.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922213_414784840.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922421_508784840.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922657_685784840.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023213_414808864.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023421_508808864.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023657_685808864.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922213_414783839.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922421_508783839.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922657_685783839.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720213_414735812.6666666666666DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720421_508735812.6666666666666DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720657_685735812.6666666666666DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821213_414759836.6666666666666DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821421_508759836.6666666666666DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821657_685759836.6666666666666DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114213_414465521.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114421_508465521.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023213_414807863.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023421_508807863.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023657_685807863.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821213_414769825.0DomainPeptidase M12B
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821421_508769825.0DomainDisintegrin
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821657_685769825.0DomainEGF-like
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821177_184759815.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821484_486759815.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922177_184784840.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922484_486784840.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023177_184808864.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023484_486808864.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922177_184783839.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922484_486783839.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720177_184735812.6666666666666MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720484_486735812.6666666666666MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821177_184759836.6666666666666MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821484_486759836.6666666666666MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114177_184465521.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023177_184807863.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023484_486807863.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821177_184769825.0MotifCysteine switch
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821484_486769825.0MotifCell attachment site
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821207_696759815.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821718_863759815.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922207_696784840.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922718_863784840.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023207_696808864.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023718_863808864.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922207_696783839.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922718_863783839.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720207_696735812.6666666666666Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720718_863735812.6666666666666Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821207_696759836.6666666666666Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821718_863759836.6666666666666Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000003684131114207_696465521.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023207_696807863.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023718_863807863.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821207_696769825.0Topological domainExtracellular
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821718_863769825.0Topological domainCytoplasmic
TgeneADAM15chr1:154947280chr1:155034720ENST000002718361821697_717759815.0TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000003559561922697_717784840.0TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000003569552023697_717808864.0TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000003592801922697_717783839.0TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000003606741720697_717735812.6666666666666TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000003684121821697_717759836.6666666666666TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000004499102023697_717807863.0TransmembraneHelical
TgeneADAM15chr1:154947280chr1:155034720ENST000005314551821697_717769825.0TransmembraneHelical


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Fusion Gene Sequence for CKS1B-ADAM15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CKS1B-ADAM15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CKS1B-ADAM15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CKS1B-ADAM15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource