FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CKS2-PCSK5 (FusionGDB2 ID:16928)

Fusion Gene Summary for CKS2-PCSK5

check button Fusion gene summary
Fusion gene informationFusion gene name: CKS2-PCSK5
Fusion gene ID: 16928
HgeneTgene
Gene symbol

CKS2

PCSK5

Gene ID

1164

5125

Gene nameCDC28 protein kinase regulatory subunit 2proprotein convertase subtilisin/kexin type 5
SynonymsCKSHS2PC5|PC6|PC6A|SPC6
Cytomap

9q22.2

9q21.13

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinases regulatory subunit 2CDC28 protein kinase 2CKS-2CKS1(S. cerevisiae Cdc28/Cdc2 kinase subunit) homolog-2proprotein convertase subtilisin/kexin type 5prohormone convertase 5proprotein convertase 6protease PC6subtilasesubtilisin/kexin-like protease PC5
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314355, ENST00000376752, 
ENST00000376767, ENST00000545128, 
Fusion gene scores* DoF score3 X 3 X 2=186 X 6 X 3=108
# samples 36
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CKS2 [Title/Abstract] AND PCSK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCKS2(91930212)-PCSK5(78789902), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePCSK5

GO:0006465

signal peptide processing

16912035

TgenePCSK5

GO:0016485

protein processing

8901832|15606899

TgenePCSK5

GO:0016486

peptide hormone processing

8901832

TgenePCSK5

GO:0043043

peptide biosynthetic process

8901832


check buttonFusion gene breakpoints across CKS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PCSK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-E1-5304-01ACKS2chr9

91930212

-PCSK5chr9

78789902

+
ChimerDB4LGGTCGA-E1-5304-01ACKS2chr9

91930212

+PCSK5chr9

78789902

+
ChimerDB4LGGTCGA-E1-5304CKS2chr9

91930212

+PCSK5chr9

78789902

+


Top

Fusion Gene ORF analysis for CKS2-PCSK5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000314355ENST00000376752CKS2chr9

91930212

+PCSK5chr9

78789902

+
In-frameENST00000314355ENST00000376767CKS2chr9

91930212

+PCSK5chr9

78789902

+
In-frameENST00000314355ENST00000545128CKS2chr9

91930212

+PCSK5chr9

78789902

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314355CKS2chr991930212+ENST00000545128PCSK5chr978789902+75262822041081362
ENST00000314355CKS2chr991930212+ENST00000376767PCSK5chr978789902+85928220598192
ENST00000314355CKS2chr991930212+ENST00000376752PCSK5chr978789902+3805282201267415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314355ENST00000545128CKS2chr991930212+PCSK5chr978789902+0.00041120.9995888
ENST00000314355ENST00000376767CKS2chr991930212+PCSK5chr978789902+0.0214952160.9785048
ENST00000314355ENST00000376752CKS2chr991930212+PCSK5chr978789902+0.0004634020.99953663

Top

Fusion Genomic Features for CKS2-PCSK5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CKS2chr991930212+PCSK5chr978789901+0.0042506680.99574935
CKS2chr991930212+PCSK5chr978789901+0.0042506680.99574935
CKS2chr991930212+PCSK5chr978789901+0.0042506680.99574935
CKS2chr991930212+PCSK5chr978789901+0.0042506680.99574935

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CKS2-PCSK5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:91930212/chr9:78789902)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211812_1853585914.0Compositional biasNote=Asp-rich
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371812_18535851861.0Compositional biasNote=Asp-rich
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221869_913585914.0DomainNote=PLAC
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237869_9135851861.0DomainNote=PLAC
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211807_1826585914.0RegionAC 1
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211838_1860585914.0RegionAC 2
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221636_1727585914.0RegionNote=CRM (Cys-rich motif)
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371807_18265851861.0RegionAC 1
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371838_18605851861.0RegionAC 2
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237636_17275851861.0RegionNote=CRM (Cys-rich motif)
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211032_1077585914.0RepeatNote=FU 9
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211079_1121585914.0RepeatNote=FU 10
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211125_1168585914.0RepeatNote=FU 11
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211177_1221585914.0RepeatNote=FU 12
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211225_1272585914.0RepeatNote=FU 13
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211274_1318585914.0RepeatNote=FU 14
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211320_1363585914.0RepeatNote=FU 15
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211365_1411585914.0RepeatNote=FU 16
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211415_1461585914.0RepeatNote=FU 17
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211465_1510585914.0RepeatNote=FU 18
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211514_1559585914.0RepeatNote=FU 19
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211563_1610585914.0RepeatNote=FU 20
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211614_1659585914.0RepeatNote=FU 21
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211665_1712585914.0RepeatNote=FU 22
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221630_680585914.0RepeatNote=FU 1
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221683_730585914.0RepeatNote=FU 2
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221734_777585914.0RepeatNote=FU 3
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221779_824585914.0RepeatNote=FU 4
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221832_879585914.0RepeatNote=FU 5
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221882_927585914.0RepeatNote=FU 6
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221929_979585914.0RepeatNote=FU 7
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221982_1028585914.0RepeatNote=FU 8
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371032_10775851861.0RepeatNote=FU 9
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371079_11215851861.0RepeatNote=FU 10
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371125_11685851861.0RepeatNote=FU 11
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371177_12215851861.0RepeatNote=FU 12
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371225_12725851861.0RepeatNote=FU 13
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371274_13185851861.0RepeatNote=FU 14
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371320_13635851861.0RepeatNote=FU 15
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371365_14115851861.0RepeatNote=FU 16
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371415_14615851861.0RepeatNote=FU 17
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371465_15105851861.0RepeatNote=FU 18
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371514_15595851861.0RepeatNote=FU 19
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371563_16105851861.0RepeatNote=FU 20
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371614_16595851861.0RepeatNote=FU 21
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371665_17125851861.0RepeatNote=FU 22
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237630_6805851861.0RepeatNote=FU 1
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237683_7305851861.0RepeatNote=FU 2
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237734_7775851861.0RepeatNote=FU 3
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237779_8245851861.0RepeatNote=FU 4
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237832_8795851861.0RepeatNote=FU 5
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237882_9275851861.0RepeatNote=FU 6
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237929_9795851861.0RepeatNote=FU 7
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237982_10285851861.0RepeatNote=FU 8
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211765_1860585914.0Topological domainCytoplasmic
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371765_18605851861.0Topological domainCytoplasmic
TgenePCSK5chr9:91930212chr9:78789902ENST0000037675212211744_1764585914.0TransmembraneHelical
TgenePCSK5chr9:91930212chr9:78789902ENST0000054512812371744_17645851861.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221134_453585914.0DomainPeptidase S8
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221461_601585914.0DomainP/Homo B
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237134_4535851861.0DomainPeptidase S8
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237461_6015851861.0DomainP/Homo B
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221519_521585914.0MotifCell attachment site
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237519_5215851861.0MotifCell attachment site
TgenePCSK5chr9:91930212chr9:78789902ENST000003767521221115_1743585914.0Topological domainExtracellular
TgenePCSK5chr9:91930212chr9:78789902ENST000005451281237115_17435851861.0Topological domainExtracellular


Top

Fusion Gene Sequence for CKS2-PCSK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16928_16928_1_CKS2-PCSK5_CKS2_chr9_91930212_ENST00000314355_PCSK5_chr9_78789902_ENST00000376752_length(transcript)=3805nt_BP=282nt
AGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCA
GCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTT
CCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGA
TTCATGAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAG
TGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTG
AGGTTGGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCT
CCAGCTGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTG
ACCAATGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATA
CCAAGAAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCC
TGCAGGGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTT
GTGCTGGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCT
ATTACTTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGA
ACTGTACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGCAACGGAAGAGTCCTGGG
CGGAAGGAGGCTTCTGTATGCTTGTGAAAAAGAACAATCTGTGCCAACGGAAGGTTCTTCAACAACTTTGCTGCAAAACATGTACATTTC
AAGGCTGAGCAGCCATCTTAGATTTCTTTGTTCCTGTAGACTTATAGATTATTCCATATTATTAAAAAGAAAAAAGCCAAAAAGAAAAAA
AAAAAAAGCAAGCCACCTCTCTCTTTCTTTTCTTGCTCTCTTTTTCTTTCTCTCTCTCTCAAGTTTGTGCAGGGAGATGGTGAACTGTTT
TGTCAGAACTTAAATGGAAAAAAAAATAAAACTACAACAAGCCTACCTTTTATAACTGGGTGTTTAGTGCTAAACAGCCAGAACCACAGA
GACAGTATTGTATGACCAAAGCATTTGATGCCAAAATTTGACGTTAAAGTAATGATTTGATTTCCTGCCCTGGTTTTGAAGGTCCATTTT
TTTCCCTTTTGCATTGACTTGCTTGTTTCCCCTTTGAAACACCTAAAAATACCTTTCCAAAACATCGCGAGAGCATACATAGACAAAAAT
GAAATAGAAAGCTCTTGCATGCTTGAGTCCACCATTGGGGGAAATGACAGAAAACTGGACCTGAGGGCATTAGGAACATCCTACAGAGTT
GTGTTTAGTGTCGTTTGCCATGGTATTTCACAGTGAAACATGGATACTCTCCACACATCATTTACTTCATGCTGTGTACTTATGTACTGG
TTTTTGCATTTTACTCACTTGATAAGTCTGCTCCACTGGTTTCATCAGATAGACTTGCTGCTACTGGCTTTTCCATTGTAGATTGGGTTA
TTTTACACGCAGTTCGCCAAATGGGATTGCTCTGTATAGTCAAATTGGTGATGGACAGATGGACAGAATGCAGAGGTACATAGATGAGCT
GAGGCTGATCCAGCTCCCCTGAAATTCAGAGTGTTAACTTTGTAGACCCTGCACAATCTCTTGGTGCTATCTAGCCATTACCCCCATTTT
TTTTTTAAAGGCCATCTGAAATTCCATTTGTCATGGTGGGAAGCATTTTGGATATGATGCAGGAAATCTCTTCCTGGAGTCAAAAGTTCC
CAAGAGGTCCTGTATTTTTAAGAAATGGAATTTATTTAAATAATATTTAAGCTTGTGCCCATGTTGGCCGGGCAACTTTTTTCAATGGTG
CTTATTAGAAGAAGTTTTTTCATCTTGTCATTTTAAGAAAATAAAACTGGAAATTGAATATGGGTGGCATGATTGTACCCTTTTAGTTCT
CTTATTTTTCTACTCCTCTGTCCCTCTATAACTATGCCATACTATTATATGCTGGTCCACTGAATGCTGAGATGATCTGTTTTTTGGGGT
TTTTTTTTTTTAAGAAATATTTTCACTGGTTTTCTGTGACTCTCTAAACACTTCATCGAAACTAGAAGACTGAATTATGAGGAAACTATT
TGGATTAGTGGCCAGAAACGATGAAATCTTATAGATCTTTTGACAGTTTCTCTGTTTAGGGGAGCCTAGACTGATATCAAGTTTCTTCAT
ATCAAAGCTTCATTGGTGACCTCATTTGCTTTACAAGTGACCAGCCATCTTGCAGGCTTCATGCTTCTGAGAGCCTTACTTAGAAGATGC
TGCTGGAGTCACAGCTGAGGAGAGGAATACTATCAACATGGACTATCCTGGGAAAGAGCTAGGAAGTAGATGCTGAGGTCCCCATCCAAA
CAGCAAGCTAGGAAAAAGCCTGCCTTGAAAATATTTCTAGACATCAAAGATAACTTACAACCCAAAGTGAATAATAAGTAAATAGTCTGA
TGACCCTCTTAATAGCATTGCAATTGTATTGAATCACATAATGATTCATAAGTAACTAGGGAACCAACTGATTTTGCTAAGCAGTCTTCC
CCTTATAACACCACAGGCCCTTCTGACACACAAAAAAATGAAAGTTAATCCTGGGTACAGCATACAGTTTTACATTTAAACGCACAGTCT
TACGTGGACAAATGCAAGCACAAGCCTAAAGCAAGGTCAAGCAGATGGCAAAACCGAATTTGCCTGCAAAGAAATCTATTTAACTGAATC
AGCCCATAATATTTGAGGCACGAGGTTACTGTGATTGATAGGAAAGATAAAAATGATGTCTGTTTTTGTAGACGAATAACCATCAACATG
ACAACAAAATTCATTGGGGTCTACCAGCGTGCATTCCATTTCCCACTGACCATGCAGGTGCACGTCGCGGAAATACTGGTTTAACTACTA
GTGTGTTACTGCCTCATTTATCTACATAACATTATTAACTAGAACATAATGCTTTCAAAGTTTAAGTTAATGTTATATATTATGTATAAA
TATATATATTCATAATGAGATATATGTAATGGATAGTACAAAGTTTGGAGACTCAACAAATGCTCTAACCTTCTAGAGACAAAAGTCCTA
TTTCTGTTTTCTTTTGTCTTTTTATTTTCAATTAGTGACCCATTGTTAAATCCAAATCCACTTTTACTGAAAAATACTGTACATGTGTAA
AATGTTCAGTTGTTTTTTTGTAAAATATAGTAGAACGGTTGTAACTGATACTGGCCAAAATCAATGTTATTCCATATTTTATTTTTTCTA

>16928_16928_1_CKS2-PCSK5_CKS2_chr9_91930212_ENST00000314355_PCSK5_chr9_78789902_ENST00000376752_length(amino acids)=415AA_BP=87
MGWTWFCLLRPLFALSFHFLQRASRMAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPGKL
KEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGH
YHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCS
VSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPS

--------------------------------------------------------------
>16928_16928_2_CKS2-PCSK5_CKS2_chr9_91930212_ENST00000314355_PCSK5_chr9_78789902_ENST00000376767_length(transcript)=859nt_BP=282nt
AGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCA
GCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTT
CCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGA
TTCATGAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAG
TGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTGAGCTGGCTTCCAGTGGGACAC
AGGCTAAAAAGAGGCAGCTCATGCATCATCCCACCACATGGGAGAACAGAATGGAATGGAATGGAATGAAATGGAATGGAATGAAATGGA
ATGGAATGGAATGGAATGGAATGGAATGGAATCGAATCGAATCGAATCGAATAGAATAGAATAGAATAGAACAGAACAGAATAGAATAGA
ACAGAACAATCTACTACCCATATTCTGACATATTTTCTTCCCCTTAAATATTTGTGTGTGTATATCAGTGCACTCATATATTCAAATATC
CATATGTGTTATCTGCAAAGCTAATAGTCCATATTGCGATTGTACCATAATATAGTTAATCTGTAATCTGGGACATATTGTTCGCTTACA

>16928_16928_2_CKS2-PCSK5_CKS2_chr9_91930212_ENST00000314355_PCSK5_chr9_78789902_ENST00000376767_length(amino acids)=192AA_BP=87
MGWTWFCLLRPLFALSFHFLQRASRMAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPGKL
KEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGELASSGTQAKKRQLMHHPTTWENRMEWNGMKWNGMKWNGMEWNG

--------------------------------------------------------------
>16928_16928_3_CKS2-PCSK5_CKS2_chr9_91930212_ENST00000314355_PCSK5_chr9_78789902_ENST00000545128_length(transcript)=7526nt_BP=282nt
AGTCTCCGGCGAGTTGTTGCCTGGGCTGGACGTGGTTTTGTCTGCTGCGCCCGCTCTTCGCGCTCTCGTTTCATTTTCTGCAGCGCGCCA
GCAGGATGGCCCACAAGCAGATCTACTACTCGGACAAGTACTTCGACGAACACTACGAGTACCGGCATGTTATGTTACCCAGAGAACTTT
CCAAACAAGTACCTAAAACTCATCTGATGTCTGAAGAGGAGTGGAGGAGACTTGGTGTCCAACAGAGTCTAGGCTGGGTTCATTACATGA
TTCATGAGCCAGGTAAATTGAAAGAATGGTCTTTGGTCCTCTACGGCACCTCCGTGCAGCCATATTCACCAACCAATGAATTTCCGAAAG
TGGAACGGTTCCGCTATAGCCGAGTTGAAGACCCCACAGACGACTATGGCACAGAGGATTATGCAGGTCCCTGCGACCCTGAGTGCAGTG
AGGTTGGCTGTGACGGGCCAGGACCAGACCACTGCAATGACTGTTTGCACTACTACTACAAGCTGAAAAACAATACCAGGATCTGTGTCT
CCAGCTGCCCCCCTGGCCACTACCACGCCGACAAGAAGCGCTGCAGGAAGTGTGCCCCCAACTGTGAGTCCTGCTTTGGGAGCCATGGTG
ACCAATGCATGTCCTGCAAATATGGATACTTTCTGAATGAAGAAACCAACAGCTGTGTTACTCACTGCCCTGATGGGTCATATCAGGATA
CCAAGAAAAATCTTTGCCGGAAATGCAGTGAAAACTGCAAGACATGTACTGAATTCCATAACTGTACAGAATGTAGGGATGGGTTAAGCC
TGCAGGGATCCCGGTGCTCTGTCTCCTGTGAAGATGGACGGTATTTCAACGGCCAGGACTGCCAGCCCTGCCACCGCTTCTGCGCCACTT
GTGCTGGGGCAGGAGCTGATGGGTGCATTAACTGCACAGAGGGCTACTTCATGGAGGATGGGAGATGCGTGCAGAGCTGTAGTATCAGCT
ATTACTTTGACCACTCTTCAGAGAATGGATACAAATCCTGCAAAAAATGTGATATCAGTTGTTTGACGTGCAATGGCCCAGGATTCAAGA
ACTGTACAAGCTGCCCTAGTGGGTATCTCTTAGACTTAGGAATGTGTCAAATGGGAGCCATTTGCAAGGATGGAGAATATGTTGATGAGC
ATGGCCACTGCCAGACCTGTGAGGCCTCATGTGCCAAGTGCCAGGGACCAACCCAGGAAGACTGCACTACCTGCCCCATGACAAGGATTT
TTGATGATGGCCGCTGTGTTTCGAACTGCCCCTCATGGAAATTTGAATTTGAGAACCAATGCCATCCATGCCACCACACCTGCCAGAGAT
GCCAAGGAAGTGGCCCTACCCACTGCACCTCCTGTGGAGCAGACAACTATGGCCGAGAGCACTTCCTGTACCAGGGAGAGTGTGGAGATA
GCTGCCCAGAGGGCCACTATGCCACTGAGGGGAACACCTGCCTGCCCTGCCCAGACAACTGTGAGCTTTGCCACAGCGTGCATGTCTGCA
CAAGATGCATGAAGGGCTACTTCATAGCGCCCACCAACCACACATGCCAGAAGTTAGAGTGTGGACAAGGTGAAGTCCAAGACCCAGACT
ATGAAGAATGTGTCCCTTGTGAAGAAGGATGTCTGGGATGCAGCTTGGATGATCCAGGAACATGTACATCTTGCGCTATGGGGTATTACA
GGTTTGATCACCATTGTTATAAAACCTGTCCTGAGAAGACCTACAGTGAGGAAGTGGAATGCAAGGCGTGTGATAGTAACTGTGGCAGCT
GTGACCAGAATGGGTGTTACTGGTGTGAAGAGGGCTTCTTTCTCTTAGGTGGCAGTTGTGTGAGGAAATGTGGTCCTGGATTCTATGGTG
ACCAAGAAATGGGAGAATGTGAGTCCTGCCACCGAGCATGCGAAACCTGCACAGGCCCTGGTCATGACGAGTGCAGCAGCTGCCAGGAAG
GACTGCAGCTGCTGCGTGGGATGTGCGTGCATGCCACCAAGACCCAGGAGGAGGGCAAATTCTGGAATGATATTTTGAGAAAACTCCAGC
CTTGTCATTCTTCTTGTAAAACCTGCAATGGATCTGCAACTCTGTGCACTTCATGTCCCAAAGGTGCATATCTTCTGGCTCAGGCCTGTG
TTTCCTCCTGTCCCCAAGGCACATGGCCTTCCGTAAGGAGTGGGAGCTGCGAGAACTGTACGGAGGCCTGTGCCATCTGCTCTGGAGCCG
ATCTTTGCAAAAAATGCCAGATGCAGCCGGGCCACCCTCTCTTCCTCCATGAAGGCAGGTGCTACTCCAAGTGCCCGGAGGGCTCTTATG
CAGAAGACGGCATATGTGAACGCTGTAGCTCTCCTTGCAGAACATGTGAAGGAAACGCCACCAACTGCCATTCTTGTGAAGGAGGCCACG
TCCTGCACCACGGAGTGTGCCAGGAAAACTGCCCCGAGAGGCACGTGGCTGTGAAGGGGGTATGCAAGCATTGCCCAGAGATGTGTCAGG
ACTGCATCCATGAGAAAACATGCAAAGAGTGCACGCCTGAGTTCTTCCTGCACGATGATATGTGCCACCAGTCCTGTCCCCGTGGCTTCT
ATGCAGACTCGCGCCACTGTGTCCCCTGCCATAAAGACTGTCTGGAGTGCAGTGGCCCCAAAGCCGACGACTGCGAGCTCTGTCTTGAGA
GTTCCTGGGTCCTCTATGATGGACTGTGCTTGGAGGAGTGTCCAGCAGGAACCTATTATGAAAAGGAGACTAAGGAGTGCAGAGATTGCC
ACAAGTCCTGCTTGACCTGCTCATCATCTGGGACCTGCACCACCTGTCAGAAAGGCCTGATCATGAACCCTCGTGGGAGCTGCATGGCCA
ACGAGAAGTGCTCACCCTCCGAGTACTGGGATGAGGATGCTCCCGGGTGCAAGCCCTGCCATGTTAAGTGCTTCCACTGCATGGGGCCGG
CGGAGGACCAGTGTCAAACATGCCCCATGAACAGCCTTCTTCTCAACACAACCTGTGTGAAGGACTGCCCAGAGGGCTATTATGCCGATG
AGGACAGCAACCGGTGTGCCCACTGCCACAGCTCTTGCAGGACATGTGAAGGGAGACACAGCAGGCAGTGCCACTCCTGCCGACCGGGCT
GGTTCCAGCTAGGAAAAGAGTGCCTGCTCCAGTGCAGGGAAGGATATTACGCAGACAACTCCACTGGCCGGTGTGAGAGGTGCAACAGGA
GCTGCAAGGGGTGCCAGGGCCCACGGCCCACAGACTGCCTGTCTTGCGATAGATTTTTCTTTCTGCTCCGCTCCAAAGGAGAGTGTCATC
GCTCCTGCCCAGACCATTACTATGTAGAGCAAAGCACACAGACCTGTGAGAGATGCCATCCGACTTGTGATCAATGCAAAGGAAAAGGAG
CGTTGAATTGTTTATCCTGTGTGTGGAGTTACCACCTCATGGGAGGGATCTGCACCTCGGACTGTCTTGTGGGGGAATACAGAGTGGGAG
AGGGAGAGAAGTTTAACTGTGAAAAATGCCACGAGAGCTGCATGGAATGCAAGGGACCAGGGGCCAAGAACTGCACCTTGTGCCCTGCCA
ACCTGGTGCTGCACATGGACGACAGCCACTGCCTCCACTGCTGCAACACCTCTGATCCCCCCAGTGCCCAGGAGTGCTGTGACTGCCAGG
ACACCACGGACGAATGCATCCTTCGAACAAGCAAGGTTAGGCCTGCAACTGAGCATTTCAAGACAGCTCTGTTCATCACCTCCTCCATGA
TGCTGGTGCTTCTGCTCGGGGCAGCTGTGGTAGTGTGGAAGAAATCTCGTGGCCGAGTCCAGCCAGCAGCAAAGGCCGGCTATGAAAAAC
TGGCCGACCCCAACAAGTCTTACTCCTCCTATAAGAGCAGCTATAGAGAGAGCACCAGCTTTGAAGAGGATCAGGTGATTGAGTACAGGG
ATCGGGACTATGATGAGGATGATGATGATGACATCGTCTACATGGGCCAGGATGGCACAGTCTACCGGAAATTTAAATATGGGCTGCTGG
ATGACGATGACATAGATGAGCTGGAATATGATGACGAGAGTTACTCCTACTACCAGTAAACAGGCACTCCCCCACCAACACCACCATTCC
ACTCTCAGGCATGCCTGTGAGCATCACTGTTTTTGGTTTTATCCCCACACCAGGCTGATGTGTGAGTTTTTCTATTTGTCTTCTTTAACC
ATGAGTCCAACCAGAATATGTAAGAATGATGAAATACTTTGTTCTTCTTTTGAGTGGCTAAACTCAATTAACAGTTCCTGTTCAACCGTA
ATTGAAGAGCAAGGATAAAATTCAGAGGCATTTTCCTCAAAATAATGTGTTAAGACACAAAAATGAAGGAAGTGAAAACAAATGAGATTT
GTACAAACTCTTCTATGTGATTTTAAAAAAAGGACAGCAGATCTATAGAAATTCTGTTTCCGAGCTGCATTGTGGAGGTGTCTGCTGCCT
CCTGGTATTCTAATTTTTCTTTATCTAATTTTGGGGATAATGGAGGTACAAAGGAGTTGTTGGTTTGGTGGTGTTTTTCTTCCCTTTAGC
TGTCTTTAGGCAGAAATTTGTTTTGTAAGGGCCAAGAAAAGAGGGCTCTTATCAATTGACTCCAGGCCACCCCTGGTGAGCAGAAGAGAC
CACCTGGGCTGGGCTGCTCAGGACCTACTTGAGATAAGGGAAGAAAAGAGAAGGTGCATCATAGCTGAGGAGCCATGAGGTCACCCCAGG
CCCTAGTTCCTCCGCAGGAATCCAGAGTCACAACAATTCTAAAGGCAGAGCAAGCCCAGCGAGAAAGAAATAACTGAATTTCCAGGAACT
GCACTCTCATGATTTTCTGGGTACTTTTCGCCTGGGAGACATCAGCTAAGACATCGAATAATAAAAGAAAAATGGCAGTGTTAACCTAAC
ATAAAATGGAATAAAATGACAAACACTTCATCCGCTCTAAAAAATTCAGAGCTTTCCTTCATCAACAACCCATCACAAAACCGTGGACTC
TCAATAGAAAGAGTTGGAATAGAGTCTAACATGGAAAAAAAAAAATCCCAATATGCTGCTCACAAGCTGTACTCTAGCTGCTGACCAGCC
TTCCAGCACTGCTCATCACTATGATTTTTGTTTCTAGACTTCCTAGGCTTCCTTTTTTCCATTCTTCTGTCAAGTGTATTCTTGGATTCA
TGCAACTGAGGACAGTTTTTGTCCAGATTGTAACACAGAGAAGGGCTCTTGCTATGCAAAATGATGTTGGCAGGGTCTTACAGATTTCCT
TGTCAAAATAGACCTTACAGGCAGTACTAGAAATGGAGCACCAGAAAGCAAAAATGACATTTTCAGAGAATGATGATAATTATAATCTAT
TGCACACCTACTACCAGATAACAAGCTAAGTAATTCCCCCCCAAAAATGCCCCACTTATCCATTTTGGTACTTACCATACTCCCATGAGG
TTGGTATTGCTATTATTCTGTTCTTGTAGGAAACCTGAGGCTTACAAGAGGTTAGGTAACTAGTCCAAGGTCATGCAAAGCTCAACAAAA
TTCAAGAAAAAAGAATGATCACCCTAAAGCGTGTGTTCTTATAACTATGCTACTGAAATAAGGTGGGAAAATAAGCATCCTAAATATAAT
TAAAGTCATGCCTATTGTTTTAGTCTATAATATCAATGTTATCTTTACTAAATTCATGGATTTTCTTTTTTTAACATAATGTATCACTGA
CACAGAAAATCTTTATGAAGAAGTCTTCAGTTTACTAAAGGCTTGTGCTTCTTTAGAGGAAAGCTCTTAAAACAGGGTTGACAAACAGTC
TCTGGAAAGAGCCAGCTAGTAAGTACATTAGGCTTTCTTGGCCAGAAAGTCTCTGTCATAACCACTCAGCTCTGCTATTATAGCATGAAT
GCAGCTGGTACATAACGGATGGGTGAGCTGTGCTTCAATAAAACCTTATTTATGGACACTGACATTTGAAATTCAGGTAATTTTCACATA
TTATAAAATTTTATTCTTCTTTTGATTTTTTTCAACCTTTTAAAATTTAAAAATGCAAAAGCTATTCTCAGTTCACAGCATTACAAGAAC
AGGTGGTGGGTCAGATTTGGCCAACAGGCTGTACTTTGCTGACTTTATCTTTAAAACAGTTTTCAGAGATCATACATGTACATGTATGAT
ATGCCTCCAAAAATTTTGATCATTTAAAATTATCTCCTTGGCCAGGCGTGGTGGCTCATACCTCTAATCCTAGCACTTTGGGAGACTGAG
GCAGGCAGATCACCTGAAGTCAGGAGTTTGATACCAGCTTAGCCAACATGGTGAAACCCCATTTCTACTAAAAATACAATAAAAATCTGG
GCATGTTGGTGCACACCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGCAAATCACTTGAGCCCGGGAGGCAGAGGTTGCAGTGAGCG
GAGATGGCACCATTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCATCTCAAAAAATAAGTAACTAACTAACTAACTAAATAAATAAAT
AAATAAAATTATCTCCTTGCCAGGACTGCTGGCTCATGCCTGTAATCCCAGCACTCTGGGAGGCTAAGGCAGGAGGATTGCTGACCCACC
ACCTGTTCTTGAGCCCAGGAGTTCGACATCAGCCTTGGACAACATAGTGAGACTCCCGTGTCTACAAAAAATTTAAAAATTAGCCAGGCA
TGGTGGCAAGTGTCTGTAGTCTCAGCTACTCAGGAGGCTAAGGTGGAAGGATCACTTGAACCCGGGAGGTCGAGGCTGCAGTGAGCTGTG
ATCTTGCTATTGCACTTCAGCCTGAATGACAGAGCTAAGACCCTGACTCAAAATAAATAAATAACATTATCTCTTCAAAATGTATCTGAA
GCCCTGATAGTTCTACTTTCAATTCTTAGAAACATATAAAAATATATGCATGATAGCCATCATATCAATGGAAGACTTTCTCACCTCTGT
GGTTGCAGTTAGCTTACAAAAACGAGCAATTTTGCTTATACTGTGTTGTTCATCTTCCTTGTTAATTCTAAAGCTCTGATAGACTGAGTT
TGACATTTCTTTCTGTAAACTGGAAATTGTTTTCTATGAAAAAAAAACTCTATGATACACAGTTAAAGATTGGTTGAGGTTGAGATGAAC
TTCAATACTAAGAAAAATTGTGGTGTTCCTCTGTGTGGCCTGCAATGAAAAGAAGGCTCATGCTTGTGTATTGAGGTTTGACATCTTTCC
TTCTTTGTTTTTAGTCATGCAACGTCATTCTTAGATGGCTTTTGAATACTATGCTAATGACTATCTAAATAGATAAATATGTGATTGGAA
AACAAAGTCACCTTTTAGTTTTCTACTTGGAAATATTAAGAGAATCCTTGTAGACTGGAAACACACCAAAAGGCTGGGTAAAGCATGGGA

>16928_16928_3_CKS2-PCSK5_CKS2_chr9_91930212_ENST00000314355_PCSK5_chr9_78789902_ENST00000545128_length(amino acids)=1362AA_BP=87
MGWTWFCLLRPLFALSFHFLQRASRMAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPGKL
KEWSLVLYGTSVQPYSPTNEFPKVERFRYSRVEDPTDDYGTEDYAGPCDPECSEVGCDGPGPDHCNDCLHYYYKLKNNTRICVSSCPPGH
YHADKKRCRKCAPNCESCFGSHGDQCMSCKYGYFLNEETNSCVTHCPDGSYQDTKKNLCRKCSENCKTCTEFHNCTECRDGLSLQGSRCS
VSCEDGRYFNGQDCQPCHRFCATCAGAGADGCINCTEGYFMEDGRCVQSCSISYYFDHSSENGYKSCKKCDISCLTCNGPGFKNCTSCPS
GYLLDLGMCQMGAICKDGEYVDEHGHCQTCEASCAKCQGPTQEDCTTCPMTRIFDDGRCVSNCPSWKFEFENQCHPCHHTCQRCQGSGPT
HCTSCGADNYGREHFLYQGECGDSCPEGHYATEGNTCLPCPDNCELCHSVHVCTRCMKGYFIAPTNHTCQKLECGQGEVQDPDYEECVPC
EEGCLGCSLDDPGTCTSCAMGYYRFDHHCYKTCPEKTYSEEVECKACDSNCGSCDQNGCYWCEEGFFLLGGSCVRKCGPGFYGDQEMGEC
ESCHRACETCTGPGHDECSSCQEGLQLLRGMCVHATKTQEEGKFWNDILRKLQPCHSSCKTCNGSATLCTSCPKGAYLLAQACVSSCPQG
TWPSVRSGSCENCTEACAICSGADLCKKCQMQPGHPLFLHEGRCYSKCPEGSYAEDGICERCSSPCRTCEGNATNCHSCEGGHVLHHGVC
QENCPERHVAVKGVCKHCPEMCQDCIHEKTCKECTPEFFLHDDMCHQSCPRGFYADSRHCVPCHKDCLECSGPKADDCELCLESSWVLYD
GLCLEECPAGTYYEKETKECRDCHKSCLTCSSSGTCTTCQKGLIMNPRGSCMANEKCSPSEYWDEDAPGCKPCHVKCFHCMGPAEDQCQT
CPMNSLLLNTTCVKDCPEGYYADEDSNRCAHCHSSCRTCEGRHSRQCHSCRPGWFQLGKECLLQCREGYYADNSTGRCERCNRSCKGCQG
PRPTDCLSCDRFFFLLRSKGECHRSCPDHYYVEQSTQTCERCHPTCDQCKGKGALNCLSCVWSYHLMGGICTSDCLVGEYRVGEGEKFNC
EKCHESCMECKGPGAKNCTLCPANLVLHMDDSHCLHCCNTSDPPSAQECCDCQDTTDECILRTSKVRPATEHFKTALFITSSMMLVLLLG
AAVVVWKKSRGRVQPAAKAGYEKLADPNKSYSSYKSSYRESTSFEEDQVIEYRDRDYDEDDDDDIVYMGQDGTVYRKFKYGLLDDDDIDE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CKS2-PCSK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CKS2-PCSK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CKS2-PCSK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource